SIMILAR PATTERNS OF AMINO ACIDS FOR 3TBG_A_RTZA2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akc ASPARTATE
AMINOTRANSFERASE

(Gallus gallus) 		PF00155
(Aminotran_1_2) 		5 LEU A  86
SER A  92
GLU A  85
LEU A 252
THR A 102
 None
 1.31A 3tbgA-1akcA:
undetectable		 3tbgA-1akcA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 THR A  78
LEU A 142
VAL A  99
LEU A  61
PHE A  80
 None
 1.23A 3tbgA-1czfA:
0.0		 3tbgA-1czfA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8l PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)

(Escherichia
coli) 		PF01330
(RuvA_N)
PF14520
(HHH_5) 		5 LEU A  75
THR A  78
VAL A  81
LEU A 113
VAL A 111
 None
 1.18A 3tbgA-1d8lA:
undetectable		 3tbgA-1d8lA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcj YHHP PROTEIN

(Escherichia
coli) 		PF01206
(TusA) 		5 LEU A  12
THR A  29
VAL A  26
VAL A  64
PHE A   5
 None
 1.41A 3tbgA-1dcjA:
0.6		 3tbgA-1dcjA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A  27
THR A  29
VAL A  35
LEU A  39
VAL A  41
 None
 1.41A 3tbgA-1dgfA:
0.0		 3tbgA-1dgfA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 THR A 312
LEU A 370
SER A 340
THR A 345
PHE A  43
 None
 1.42A 3tbgA-1hkwA:
0.0		 3tbgA-1hkwA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		5 LEU A 230
THR A 235
LEU A 132
PHE A 152
PHE A 135
 None
 1.37A 3tbgA-1i6qA:
0.0		 3tbgA-1i6qA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 THR A 400
THR A 179
VAL A 177
VAL A 347
PHE A 393
 None
 1.03A 3tbgA-1i8qA:
0.0		 3tbgA-1i8qA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m93 SERINE PROTEINASE
INHIBITOR 2

(Cowpox virus) 		PF00079
(Serpin) 		5 THR B  95
VAL B  88
SER B 298
LEU B 125
THR B 123
 None
 1.34A 3tbgA-1m93B:
undetectable		 3tbgA-1m93B:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny1 PROBABLE
POLYSACCHARIDE
DEACETYLASE PDAA

(Bacillus
subtilis) 		PF01522
(Polysacc_deac_1) 		5 LEU A 131
VAL A 173
VAL A 185
THR A 184
PHE A  98
 None
 1.41A 3tbgA-1ny1A:
undetectable		 3tbgA-1ny1A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ojz ADP-RIBOSYLTRANSFERA
SE

(Staphylococcus
aureus) 		PF03496
(ADPrib_exo_Tox) 		5 THR A 187
LEU A 156
VAL A  83
VAL A  76
THR A  77
 None
 1.15A 3tbgA-1ojzA:
undetectable		 3tbgA-1ojzA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz9 KYNURENINASE

(Pseudomonas
fluorescens) 		PF00266
(Aminotran_5) 		5 THR A 124
LEU A 101
THR A  97
LEU A 171
VAL A 174
 None
None
PLP  A1227 (-3.8A)
None
None
 1.18A 3tbgA-1qz9A:
undetectable		 3tbgA-1qz9A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txo PUTATIVE BACTERIAL
ENZYME

(Mycobacterium
tuberculosis) 		PF13672
(PP2C_2) 		5 THR A 102
THR A 130
SER A 194
LEU A 188
VAL A 235
 None
 1.42A 3tbgA-1txoA:
undetectable		 3tbgA-1txoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkg MAJOR MITE FECAL
ALLERGEN DER P 1

(Dermatophagoides
pteronyssinus) 		PF00112
(Peptidase_C1) 		5 LEU A 137
SER A 118
GLU A 139
VAL A 102
THR A 103
 None
None
YT3  A 401 (-2.8A)
None
None
 1.17A 3tbgA-1xkgA:
undetectable		 3tbgA-1xkgA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA

(Bacillus
subtilis) 		PF00496
(SBP_bac_5) 		5 THR A 484
LEU A 364
THR A 393
VAL A 391
LEU A 291
 None
 1.21A 3tbgA-1xocA:
undetectable		 3tbgA-1xocA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye9 CATALASE HPII

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 279
THR A 287
VAL A 289
LEU E 336
PHE A 138
 None
 1.22A 3tbgA-1ye9A:
undetectable		 3tbgA-1ye9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7n L(+)-MANDELATE
DEHYDROGENASE

(Pseudomonas
putida;
Spinacia
oleracea) 		PF01070
(FMN_dh) 		5 LEU A 314
THR A 310
VAL A 322
SER A 111
LEU A  92
 None
 1.28A 3tbgA-2a7nA:
undetectable		 3tbgA-2a7nA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 THR A  74
LEU A  94
VAL A 101
VAL A  60
THR A  61
 None
 1.32A 3tbgA-2clpA:
undetectable		 3tbgA-2clpA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A  90
THR A  91
VAL A 116
THR A 117
PHE A 127
 None
 1.43A 3tbgA-2ctzA:
undetectable		 3tbgA-2ctzA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg6 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF13411
(MerR_1) 		5 LEU A  89
VAL A  67
SER A 128
LEU A  82
VAL A  80
 None
 1.02A 3tbgA-2dg6A:
undetectable		 3tbgA-2dg6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0x GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 VAL B 397
SER A 289
LEU B 477
VAL B 470
THR B 475
 None
 1.18A 3tbgA-2e0xB:
undetectable		 3tbgA-2e0xB:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ezv TYPE II RESTRICTION
ENZYME SFII

(Streptomyces
fimbriatus) 		PF11487
(RestrictionSfiI) 		5 LEU A  62
VAL A  99
GLU A  66
LEU A  21
THR A 157
 None
 1.29A 3tbgA-2ezvA:
undetectable		 3tbgA-2ezvA:
19.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 THR A  54
VAL A  78
LEU A 372
THR A 375
PHE A 481
 None
 0.72A 3tbgA-2f9qA:
54.3		 3tbgA-2f9qA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		5 LEU A  49
THR A 250
LEU A 377
VAL A  77
PHE A 376
 None
 1.41A 3tbgA-2gsnA:
undetectable		 3tbgA-2gsnA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 GLU A 610
LEU A 454
VAL A 459
PHE A 403
PHE A 399
 None
 1.31A 3tbgA-2hpiA:
undetectable		 3tbgA-2hpiA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olg PRO-PHENOLOXIDASE
ACTIVATING ENZYME-I

(Holotrichia
diomphalia) 		PF00089
(Trypsin) 		5 LEU A 320
THR A 255
VAL A 257
VAL A 117
THR A 116
 None
 1.20A 3tbgA-2olgA:
undetectable		 3tbgA-2olgA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfv EXOCYST COMPLEX
COMPONENT EXO70

(Saccharomyces
cerevisiae) 		PF03081
(Exo70) 		5 THR A 563
LEU A 618
THR A 615
LEU A 577
VAL A 575
 None
 1.38A 3tbgA-2pfvA:
2.3		 3tbgA-2pfvA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk9 PHO85 CYCLIN PHO80

(Saccharomyces
cerevisiae) 		PF08613
(Cyclin) 		5 THR B 127
LEU B 155
VAL B 150
SER B 139
LEU B  84
 None
 1.34A 3tbgA-2pk9B:
undetectable		 3tbgA-2pk9B:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v35 ELASTASE-1

(Sus scrofa) 		PF00089
(Trypsin) 		5 VAL A  16
SER A  29
LEU A 199
VAL A 212
THR A 213
 None
 1.38A 3tbgA-2v35A:
undetectable		 3tbgA-2v35A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		5 THR A 164
THR A 191
VAL A 187
LEU A  84
VAL A  71
 None
 1.27A 3tbgA-2ww9A:
undetectable		 3tbgA-2ww9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		5 THR A 222
VAL A 321
VAL A 134
PHE A 165
PHE A 161
 None
 1.34A 3tbgA-2yikA:
undetectable		 3tbgA-2yikA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo6 CYAN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN (KCY)

(Verrillofungia
concinna) 		PF01353
(GFP) 		5 THR A 174
SER A 118
LEU A  56
THR A  59
PHE A  23
 None
None
None
GYS  A  63 ( 4.1A)
None
 1.42A 3tbgA-2zo6A:
undetectable		 3tbgA-2zo6A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo7 CYAN/GREEN-EMITTING
GFP-LIKE PROTEIN,
KUSABIRA-CYAN MUTANT
(KCY-R1)

(Verrillofungia
concinna) 		PF01353
(GFP) 		5 THR A 175
SER A 119
LEU A  57
THR A  60
PHE A  24
 None
None
None
GYS  A  64 ( 4.2A)
None
 1.41A 3tbgA-2zo7A:
undetectable		 3tbgA-2zo7A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		5 LEU A 560
THR A 558
VAL A 574
THR A 575
PHE A 639
 None
 1.23A 3tbgA-2zwsA:
undetectable		 3tbgA-2zwsA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 LEU A 282
THR A 285
VAL A 494
LEU A 195
THR A 208
 None
 1.37A 3tbgA-3a24A:
undetectable		 3tbgA-3a24A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au0 CLUMPING FACTOR B

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		5 THR A 439
VAL A 436
SER A 445
LEU A 488
VAL A 394
 None
 1.40A 3tbgA-3au0A:
undetectable		 3tbgA-3au0A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bnk FLAVOREDOXIN

(Methanosarcina
acetivorans) 		PF01613
(Flavin_Reduct) 		5 LEU A  21
THR A  19
VAL A  69
VAL A  40
PHE A 132
 None
 1.31A 3tbgA-3bnkA:
undetectable		 3tbgA-3bnkA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		5 THR A  78
LEU A  94
VAL A  89
VAL A 285
THR A 284
 None
 1.39A 3tbgA-3cg3A:
undetectable		 3tbgA-3cg3A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctm CARBONYL REDUCTASE

(Candida
parapsilosis) 		PF13561
(adh_short_C2) 		5 THR A 124
THR A 101
VAL A  98
SER A  43
VAL A 116
 None
 1.43A 3tbgA-3ctmA:
undetectable		 3tbgA-3ctmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmf DETHIOBIOTIN
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF13500
(AAA_26) 		5 THR A   7
LEU A 156
VAL A 161
LEU A 124
VAL A 122
 None
 1.19A 3tbgA-3fmfA:
undetectable		 3tbgA-3fmfA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl3 PUTATIVE
THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Chlorobaculum
tepidum) 		PF08534
(Redoxin) 		5 THR A 123
LEU A  59
VAL A  91
LEU A  40
VAL A  46
 None
 1.21A 3tbgA-3gl3A:
undetectable		 3tbgA-3gl3A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glg DNA POLYMERASE III
SUBUNIT DELTA

(Escherichia
coli) 		PF06144
(DNA_pol3_delta)
PF14840
(DNA_pol3_delt_C) 		5 LEU A  81
THR A  79
SER A  34
LEU A  22
VAL A 135
 None
 1.36A 3tbgA-3glgA:
2.2		 3tbgA-3glgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjz TRANSALDOLASE B

(Prochlorococcus
marinus) 		PF00923
(TAL_FSA) 		5 THR A 139
SER A 307
GLU A  99
LEU A 299
PHE A 106
 CL  A 344 (-4.3A)
None
NA  A 340 ( 2.9A)
None
None
 1.29A 3tbgA-3hjzA:
undetectable		 3tbgA-3hjzA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		5 LEU A 214
VAL A 184
LEU A 150
VAL A 154
THR A 155
 None
 1.14A 3tbgA-3hxkA:
undetectable		 3tbgA-3hxkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		5 THR A 154
LEU A 270
THR A 267
LEU A 252
THR A 231
 None
 1.39A 3tbgA-3i09A:
undetectable		 3tbgA-3i09A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A 446
GLU A 413
LEU A 368
PHE A 477
PHE A 474
 None
 1.30A 3tbgA-3iveA:
undetectable		 3tbgA-3iveA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		5 THR A  89
VAL A  93
GLU A 462
LEU A 383
VAL A 381
 None
 1.05A 3tbgA-3izkA:
1.3		 3tbgA-3izkA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		5 THR A  89
VAL A  93
SER A 374
GLU A 462
LEU A 383
 None
 1.38A 3tbgA-3izkA:
1.3		 3tbgA-3izkA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k85 D-GLYCERO-D-MANNO-HE
PTOSE 1-PHOSPHATE
KINASE

(Bacteroides
thetaiotaomicron) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 THR A 241
VAL A 305
LEU A 245
VAL A 191
PHE A 168
 None
 1.22A 3tbgA-3k85A:
2.7		 3tbgA-3k85A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kr9 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF04816
(TrmK) 		5 THR A  89
LEU A   6
GLU A   7
LEU A  19
VAL A  34
 None
 1.37A 3tbgA-3kr9A:
undetectable		 3tbgA-3kr9A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m52 ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17

(Homo sapiens) 		PF00651
(BTB) 		5 LEU A  62
SER A  46
LEU A  70
VAL A  92
PHE A  28
 None
 1.38A 3tbgA-3m52A:
undetectable		 3tbgA-3m52A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		5 LEU A  70
VAL A  66
LEU A 118
VAL A  57
THR A  58
 None
 1.35A 3tbgA-3mwgA:
undetectable		 3tbgA-3mwgA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		5 LEU A  60
VAL A  55
SER A  39
GLU A  41
PHE A 120
 None
SO4  A 233 (-4.2A)
None
None
None
 1.43A 3tbgA-3ntvA:
undetectable		 3tbgA-3ntvA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnr FALCIPAIN 2

(Plasmodium
falciparum) 		PF00112
(Peptidase_C1) 		5 LEU A  65
SER A  46
GLU A  67
VAL A  30
THR A  31
 None
 0.99A 3tbgA-3pnrA:
undetectable		 3tbgA-3pnrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmj ENOYL-COA HYDRATASE,
ECHA8_6

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 LEU A  14
THR A  13
VAL A  49
SER A  59
LEU A  90
 None
 1.37A 3tbgA-3qmjA:
undetectable		 3tbgA-3qmjA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 LEU A  61
VAL A  58
SER A  96
LEU A  84
PHE A 124
 None
 1.19A 3tbgA-3t3oA:
undetectable		 3tbgA-3t3oA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc8 LEUCINE
AMINOPEPTIDASE

(Parabacteroides
distasonis) 		PF04389
(Peptidase_M28) 		5 LEU A 323
VAL A 322
SER A  46
VAL A 152
PHE A  81
 None
 1.35A 3tbgA-3tc8A:
undetectable		 3tbgA-3tc8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3to3 PETROBACTIN
BIOSYNTHESIS PROTEIN
ASBB

(Bacillus
anthracis) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 THR A 125
VAL A  24
GLU A 121
LEU A  32
PHE A 105
 None
 1.42A 3tbgA-3to3A:
undetectable		 3tbgA-3to3A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgp TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE,
PUTATIVE

(Archaeoglobus
fulgidus) 		no annotation 5 THR A 518
LEU A 576
VAL A 577
PHE A 496
PHE A 495
 None
 1.42A 3tbgA-3vgpA:
undetectable		 3tbgA-3vgpA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		5 LEU A 324
THR A 322
GLU A 325
VAL A  10
PHE A 406
 None
 1.30A 3tbgA-3vocA:
undetectable		 3tbgA-3vocA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		5 THR B 133
THR B 282
VAL B 279
GLU B 251
LEU B 137
 None
2XP  B 402 (-3.6A)
2XP  B 402 ( 4.6A)
FE2  B 401 ( 2.5A)
None
 1.32A 3tbgA-3vsjB:
undetectable		 3tbgA-3vsjB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2x EXODEOXYRIBONUCLEASE

(Methanothermobacter
thermautotrophicus) 		PF03372
(Exo_endo_phos) 		5 THR A  75
VAL A  77
LEU A 257
VAL A   3
PHE A 230
 None
 1.40A 3tbgA-3w2xA:
undetectable		 3tbgA-3w2xA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		5 LEU A  21
THR A  22
LEU A  98
VAL A 132
PHE A 123
 None
 1.39A 3tbgA-3zbmA:
undetectable		 3tbgA-3zbmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA
F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6) 		5 THR A 351
VAL A 349
LEU A  43
VAL A  40
PHE B 138
 None
 1.32A 3tbgA-4ci0A:
0.7		 3tbgA-4ci0A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
ALPHA
F420-REDUCING
HYDROGENASE, SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF00037
(Fer4)
PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6) 		5 VAL A 349
LEU A  43
VAL A  40
THR A 385
PHE B 138
 None
 1.38A 3tbgA-4ci0A:
0.7		 3tbgA-4ci0A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5
ELONGATOR COMPLEX
PROTEIN 6

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1)
no annotation 		5 LEU B 197
VAL B 173
GLU C 256
LEU B 179
THR B 176
 None
 1.09A 3tbgA-4ejsB:
undetectable		 3tbgA-4ejsB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		5 THR A 345
SER A 484
GLU A 931
VAL A 447
THR A 446
 None
 1.39A 3tbgA-4f7zA:
undetectable		 3tbgA-4f7zA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 329
THR A 179
VAL A 182
SER A 166
LEU A 207
 None
 1.23A 3tbgA-4gmfA:
undetectable		 3tbgA-4gmfA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr5 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Streptomyces
lydicus) 		PF00501
(AMP-binding)
PF03621
(MbtH) 		5 THR A 239
THR A 447
VAL A 411
LEU A 386
VAL A 384
 None
 1.41A 3tbgA-4gr5A:
undetectable		 3tbgA-4gr5A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		5 LEU A 269
VAL A  29
LEU A   7
VAL A 134
THR A 133
 None
 1.32A 3tbgA-4i70A:
undetectable		 3tbgA-4i70A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iik ADENOSINE
MONOPHOSPHATE-PROTEI
N HYDROLASE SIDD

(Legionella
pneumophila) 		no annotation 5 THR A 240
VAL A 242
SER A 172
LEU A 333
VAL A 249
 None
 1.18A 3tbgA-4iikA:
undetectable		 3tbgA-4iikA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj6 ACETYL XYLAN
ESTERASE

(Geobacillus
stearothermophilus) 		PF13472
(Lipase_GDSL_2) 		5 THR A 124
VAL A 128
LEU A   9
VAL A  57
PHE A 207
 None
 1.22A 3tbgA-4jj6A:
undetectable		 3tbgA-4jj6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxc FEFE-HYDROGENASE
MATURASE

(Thermotoga
maritima) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		5 LEU A 250
THR A 249
VAL A 253
LEU A 283
THR A 268
 None
None
None
None
CL  A 414 ( 4.4A)
 1.39A 3tbgA-4jxcA:
undetectable		 3tbgA-4jxcA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 THR A 471
VAL A 201
GLU A 167
VAL A 879
THR A 883
 None
 1.33A 3tbgA-4kxbA:
2.3		 3tbgA-4kxbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ler PUTATIVE OUTER
MEMBRANE PROTEIN,
PROBABLY INVOLVED IN
NUTRIENT BINDING

(Bacteroides
vulgatus) 		PF12771
(SusD-like_2) 		5 SER A 104
GLU A 102
LEU A  42
VAL A  93
THR A  94
 CL  A 501 ( 4.2A)
None
None
None
None
 1.24A 3tbgA-4lerA:
undetectable		 3tbgA-4lerA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3c LECTIN BETA CHAIN

(Butea
monosperma) 		PF00139
(Lectin_legB) 		5 LEU B 204
VAL B 203
SER B  69
LEU B 179
VAL B 197
 None
 1.29A 3tbgA-4m3cB:
undetectable		 3tbgA-4m3cB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj3 HALOALKANE
DEHALOGENASE

(Mycolicibacterium
rhodesiae) 		PF00561
(Abhydrolase_1) 		5 THR A 148
LEU A 119
VAL A 133
LEU A 260
PHE A 246
 None
 1.17A 3tbgA-4mj3A:
undetectable		 3tbgA-4mj3A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxm TRANSCRIPTIONAL
REGULATOR I2

(Pseudomonas
fluorescens) 		PF00440
(TetR_N) 		5 LEU A 164
THR A 160
VAL A 194
LEU A  93
VAL A  88
 None
 1.12A 3tbgA-4mxmA:
1.7		 3tbgA-4mxmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III

(Scadoxus
multiflorus) 		PF00704
(Glyco_hydro_18) 		5 LEU A  18
THR A  21
GLU A  15
LEU A  72
PHE A  34
 None
 1.35A 3tbgA-4n42A:
undetectable		 3tbgA-4n42A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8m TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Actinobacillus
succinogenes) 		PF03480
(DctP) 		5 LEU A  77
THR A  88
VAL A 240
SER A 174
LEU A 102
 None
 1.36A 3tbgA-4o8mA:
undetectable		 3tbgA-4o8mA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or8 MEMBRANE-ASSOCIATED
PROTEIN VP24

(Marburg
marburgvirus) 		PF06389
(Filo_VP24) 		5 LEU A 198
THR A 191
VAL A 193
GLU A 200
LEU A  60
 None
 1.34A 3tbgA-4or8A:
undetectable		 3tbgA-4or8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER

(Neisseria
gonorrhoeae) 		PF03806
(ABG_transport) 		5 THR A 452
LEU A 486
LEU A 411
THR A  15
PHE A 408
 None
 1.31A 3tbgA-4r1iA:
undetectable		 3tbgA-4r1iA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		5 LEU A  40
SER A  49
GLU A  45
LEU A  57
VAL A 309
 None
 1.35A 3tbgA-4r33A:
undetectable		 3tbgA-4r33A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae) 		PF00079
(Serpin) 		5 LEU A 191
THR A 190
VAL A 342
LEU A 312
PHE A  41
 None
 1.09A 3tbgA-4roaA:
undetectable		 3tbgA-4roaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN

(Thielavia
terrestris) 		PF07470
(Glyco_hydro_88) 		5 LEU A 158
THR A 157
VAL A 162
LEU A 186
PHE A 252
 None
 1.26A 3tbgA-4xuvA:
undetectable		 3tbgA-4xuvA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yue S4B6 FAB LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU L 182
THR L 181
VAL L 162
SER L 211
VAL L 199
 None
 1.34A 3tbgA-4yueL:
undetectable		 3tbgA-4yueL:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5p CYTOCHROME P450
HYDROXYLASE

(Streptomyces
atroolivaceus) 		PF00067
(p450) 		5 LEU A 252
THR A 254
LEU A 245
VAL A 137
PHE A 120
 None
 1.25A 3tbgA-4z5pA:
28.7		 3tbgA-4z5pA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpi PUTATIVE
OXIDASE/HYDROXYLASE

(Streptomyces
hygroscopicus) 		PF05721
(PhyH) 		5 LEU A 187
THR A 186
VAL A 156
LEU A 167
PHE A 256
 None
 1.13A 3tbgA-4zpiA:
undetectable		 3tbgA-4zpiA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoz PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin) 		5 THR A 460
VAL A 462
VAL A 517
PHE A 409
PHE A 407
 None
 1.29A 3tbgA-5aozA:
undetectable		 3tbgA-5aozA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		5 LEU A 308
THR A 309
SER A 301
GLU A 305
THR A 313
 None
None
C5P  A 501 (-2.6A)
None
None
 1.40A 3tbgA-5fa1A:
undetectable		 3tbgA-5fa1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Aspergillus
fumigatus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A 296
GLU A 268
LEU A 166
PHE A 259
PHE A 170
 None
 1.25A 3tbgA-5jw6A:
undetectable		 3tbgA-5jw6A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 352
THR A 353
SER A 449
GLU A 456
LEU A 405
 None
 1.43A 3tbgA-5kbrA:
undetectable		 3tbgA-5kbrA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2o PUTATIVE
CELLULOSOMAL
SCAFFOLDIN PROTEIN

(Ruminococcus
flavefaciens) 		PF00963
(Cohesin) 		5 THR A  63
VAL A  65
VAL A 120
PHE A  12
PHE A  10
 None
 1.37A 3tbgA-5m2oA:
undetectable		 3tbgA-5m2oA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanotorris
formicicus) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 LEU A  89
VAL A  84
SER A 312
THR A  80
PHE A 522
 None
 1.35A 3tbgA-5n28A:
2.4		 3tbgA-5n28A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN
SMALL ENVELOPE
PROTEIN M

(Tick-borne
encephalitis
virus) 		no annotation 5 THR D  53
VAL D  49
LEU A 460
VAL A 462
PHE A 449
 None
 1.39A 3tbgA-5o6vD:
undetectable		 3tbgA-5o6vD:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 LEU A 856
THR A 863
VAL A 757
GLU A 836
PHE A 766
 None
 1.40A 3tbgA-5okoA:
undetectable		 3tbgA-5okoA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 LEU A 265
VAL A 257
LEU A 343
VAL A 324
PHE A 242
 None
 1.10A 3tbgA-5ucdA:
1.4		 3tbgA-5ucdA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi UNCHARACTERIZED
PROTEIN

(Trichomonas
vaginalis) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 THR C 172
VAL C 169
SER C 215
LEU C 203
VAL C 194
 U  2 907 ( 3.7A)
None
U  2   3 ( 3.5A)
None
C  2   2 ( 4.7A)
 1.34A 3tbgA-5xyiC:
undetectable		 3tbgA-5xyiC:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 5 THR B  52
LEU A 180
GLU A 181
VAL B 189
PHE B 114
 None
 1.29A 3tbgA-6cxhB:
undetectable		 3tbgA-6cxhB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnu METHYLENETETRAHYDROF
OLATE REDUCTASE 1

(Saccharomyces
cerevisiae) 		no annotation 5 SER A  16
LEU A 105
VAL A  48
THR A  49
PHE A 185
 None
None
None
FAD  A 701 (-4.1A)
None
 1.33A 3tbgA-6fnuA:
undetectable		 3tbgA-6fnuA:
11.96