SIMILAR PATTERNS OF AMINO ACIDS FOR 3TBG_A_RTZA1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqc PROTEIN
(BETA-MANNANASE)

(Thermobifida
fusca) 		PF00150
(Cellulase) 		5 PHE A 301
GLY A   3
LEU A   4
GLU A  13
PHE A  19
 None
 1.21A 3tbgA-1bqcA:
0.0		 3tbgA-1bqcA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)

(Rattus
norvegicus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 LEU A  86
GLY A 154
LEU A 153
SER A 110
PHE A 215
 None
 1.32A 3tbgA-1bu8A:
0.0		 3tbgA-1bu8A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 LEU A 937
LEU A 910
GLY A 988
GLN A 956
PHE A 955
 None
 1.25A 3tbgA-1f4hA:
0.0		 3tbgA-1f4hA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		5 LEU A1062
PHE A1063
GLY A1302
GLU A1034
GLN A1306
 None
None
2FP  A5001 (-3.6A)
None
None
 1.35A 3tbgA-1fdjA:
0.0		 3tbgA-1fdjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 LEU A  86
GLY A 154
LEU A 153
SER A 110
PHE A 215
 None
 1.24A 3tbgA-1hplA:
undetectable		 3tbgA-1hplA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Galdieria
partita) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 145
PHE A 148
PHE A 108
LEU A 116
LEU A  37
 None
 1.34A 3tbgA-1iwaA:
0.0		 3tbgA-1iwaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhl IGG1-KAPPA D11.15 FV
(LIGHT CHAIN)

(Mus musculus) 		PF07686
(V-set) 		5 PHE L  62
GLY L  16
LEU L  78
GLU L  79
SER L  76
 None
 1.35A 3tbgA-1jhlL:
undetectable		 3tbgA-1jhlL:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsx GLUCOSE-INHIBITED
DIVISION PROTEIN B

(Escherichia
coli) 		PF02527
(GidB) 		5 LEU A 112
LEU A  24
GLY A  77
LEU A  78
PHE A 104
 None
 1.33A 3tbgA-1jsxA:
0.0		 3tbgA-1jsxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		5 LEU A  59
GLY A 267
GLU A 214
ASP A 293
SER A 262
 PRH  A 401 (-4.5A)
None
PRH  A 401 (-2.5A)
PRH  A 401 (-3.5A)
None
 1.27A 3tbgA-1krmA:
0.0		 3tbgA-1krmA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Methanothermobacter
thermautotrophicus) 		PF00483
(NTP_transferase) 		5 GLY A 107
LEU A   6
GLN A  24
ASP A  57
SER A  53
 TYD  A3001 (-4.1A)
TYD  A3001 (-3.5A)
TYD  A3001 (-3.5A)
None
None
 1.07A 3tbgA-1lvwA:
undetectable		 3tbgA-1lvwA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvj PYROGENIC EXOTOXIN B

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		5 LEU A 369
LEU A 372
GLY A 333
GLN A 390
SER A 123
 None
 1.27A 3tbgA-1pvjA:
undetectable		 3tbgA-1pvjA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		5 LEU A 479
GLY A 708
LEU A 686
GLU A 687
PHE A 709
 CIT  A1101 (-3.7A)
ACT  A1107 ( 4.2A)
None
None
None
 1.22A 3tbgA-1xf1A:
undetectable		 3tbgA-1xf1A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		5 LEU A 196
GLY A 370
LEU A 373
PHE A 201
SER A 199
 None
 1.25A 3tbgA-1ybeA:
undetectable		 3tbgA-1ybeA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		5 PHE A 209
GLY A 229
ASP A 238
SER A 239
PHE A 101
 None
 1.27A 3tbgA-1ybeA:
undetectable		 3tbgA-1ybeA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 713
PHE A 592
LEU A 569
GLY A 573
LEU A 580
 None
 1.03A 3tbgA-1yr2A:
undetectable		 3tbgA-1yr2A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adf 82D6A3 IGG

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE L  62
GLY L  16
LEU L  78
GLU L  79
SER L  76
 None
 1.26A 3tbgA-2adfL:
undetectable		 3tbgA-2adfL:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis) 		PF01182
(Glucosamine_iso) 		5 PHE A 141
LEU A 157
GLY A  71
LEU A  72
PHE A 169
 None
 1.33A 3tbgA-2bkxA:
undetectable		 3tbgA-2bkxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7d UVRABC SYSTEM
PROTEIN B

(Bacillus
subtilis) 		PF00271
(Helicase_C)
PF02151
(UVR)
PF04851
(ResIII)
PF12344
(UvrB) 		5 LEU A 528
PHE A 527
GLY A 501
LEU A 475
SER A 477
 None
 1.21A 3tbgA-2d7dA:
undetectable		 3tbgA-2d7dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		5 LEU A 488
PHE A 525
LEU A 523
GLY A 476
SER A 451
 None
 1.22A 3tbgA-2dh3A:
undetectable		 3tbgA-2dh3A:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		8 LEU A 110
PHE A 112
PHE A 120
LEU A 121
GLY A 212
GLN A 244
ASP A 301
SER A 304
 None
None
HEM  A 600 (-4.6A)
None
None
None
None
None
 1.18A 3tbgA-2f9qA:
54.3		 3tbgA-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		8 LEU A 110
PHE A 112
PHE A 120
LEU A 121
GLY A 212
PHE A 247
ASP A 301
SER A 304
 None
None
HEM  A 600 (-4.6A)
None
None
None
None
None
 0.80A 3tbgA-2f9qA:
54.3		 3tbgA-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 110
PHE A 112
PHE A 120
LEU A 121
PHE A 483
 None
None
HEM  A 600 (-4.6A)
None
None
 0.98A 3tbgA-2f9qA:
54.3		 3tbgA-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 248
GLY A 212
GLN A 244
ASP A 301
SER A 304
 None
 1.34A 3tbgA-2f9qA:
54.3		 3tbgA-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 120
LEU A 121
GLY A 212
LEU A 213
GLU A 216
GLN A 244
 HEM  A 600 (-4.6A)
None
None
None
None
None
 1.32A 3tbgA-2f9qA:
54.3		 3tbgA-2f9qA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ge3 PROBABLE
ACETYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00583
(Acetyltransf_1) 		5 LEU A 111
PHE A 168
PHE A 117
LEU A 119
PHE A  61
 None
 1.16A 3tbgA-2ge3A:
undetectable		 3tbgA-2ge3A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdc GLYPHOSATE
N-ACETYLTRANSFERASE

(Bacillus
licheniformis) 		PF00583
(Acetyltransf_1) 		5 PHE A 123
LEU A 121
LEU A  98
GLU A  95
PHE A  56
 None
 1.26A 3tbgA-2jdcA:
undetectable		 3tbgA-2jdcA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg2 SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
paucimobilis) 		PF00155
(Aminotran_1_2) 		5 LEU A 229
LEU A 154
GLY A 140
LEU A 139
SER A 161
 None
None
None
None
PLP  A1265 (-3.3A)
 1.32A 3tbgA-2jg2A:
undetectable		 3tbgA-2jg2A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld7 HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP30
PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A

(Mus musculus) 		PF02671
(PAH)
PF13867
(SAP30_Sin3_bdg) 		5 PHE B 516
PHE B 508
LEU A 150
GLN A 152
PHE A 186
 None
 1.32A 3tbgA-2ld7B:
undetectable		 3tbgA-2ld7B:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 PHE A 314
PHE A 283
GLY A 321
LEU A 360
GLN A 320
 None
 1.22A 3tbgA-2nsmA:
undetectable		 3tbgA-2nsmA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 LEU A 460
GLY A 287
LEU A 286
GLU A 285
ASP A 399
 None
 1.27A 3tbgA-2uvfA:
undetectable		 3tbgA-2uvfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 282
PHE A 182
LEU A 231
GLY A 227
ASP A 181
 None
 1.36A 3tbgA-2uxtA:
undetectable		 3tbgA-2uxtA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		5 LEU A 358
PHE A 354
LEU A 282
GLY A 387
LEU A 389
 None
 1.34A 3tbgA-2vn7A:
undetectable		 3tbgA-2vn7A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		5 LEU A 645
PHE A 748
LEU A 638
GLY A 696
GLN A 633
 None
 1.20A 3tbgA-2zzgA:
1.8		 3tbgA-2zzgA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		5 LEU A  79
PHE A  86
GLY A 197
LEU A 200
ASP A 158
 None
 1.27A 3tbgA-3a4tA:
undetectable		 3tbgA-3a4tA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ceu THIAMINE PHOSPHATE
PYROPHOSPHORYLASE

(Bacteroides
thetaiotaomicron) 		PF02581
(TMP-TENI) 		5 LEU A 150
PHE A 112
GLY A 173
LEU A 175
PHE A 194
 None
 1.29A 3tbgA-3ceuA:
undetectable		 3tbgA-3ceuA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7n D-RIBOSE
HIGH-AFFINITY
TRANSPORT SYSTEM

(Salmonella
enterica) 		PF05025
(RbsD_FucU) 		5 PHE A  51
LEU A  80
GLY A  30
LEU A  31
SER A 122
 None
None
EDO  A 300 (-4.1A)
EDO  A 300 (-4.3A)
None
 1.26A 3tbgA-3e7nA:
undetectable		 3tbgA-3e7nA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 PHE C  27
GLY C 272
LEU C 275
PHE C 273
SER C 277
 None
 1.07A 3tbgA-3gi8C:
1.1		 3tbgA-3gi8C:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		5 PHE A 280
LEU A 225
LEU A 288
ASP A 278
PHE A 247
 None
 1.09A 3tbgA-3h39A:
undetectable		 3tbgA-3h39A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiq VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		5 LEU A 186
PHE A  19
LEU A  20
GLY A 140
LEU A 144
 None
 1.13A 3tbgA-3hiqA:
undetectable		 3tbgA-3hiqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiw VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		5 LEU A 186
PHE A  19
LEU A  20
GLY A 140
LEU A 144
 None
 1.12A 3tbgA-3hiwA:
undetectable		 3tbgA-3hiwA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		5 LEU A 372
PHE A 369
PHE A 118
GLY A 109
LEU A 111
 None
 1.15A 3tbgA-3j09A:
2.2		 3tbgA-3j09A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		5 LEU A 257
PHE A 324
LEU A 299
GLY A 287
LEU A 286
 None
 1.29A 3tbgA-3k2gA:
undetectable		 3tbgA-3k2gA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv0 HET-C2

(Podospora
anserina) 		PF08718
(GLTP) 		5 LEU A 190
LEU A 121
GLY A 113
SER A 138
PHE A  60
 None
 1.32A 3tbgA-3kv0A:
1.7		 3tbgA-3kv0A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 PHE A-188
GLY A -44
LEU A -45
GLU A-233
ASP A-330
 MAL  A 194 (-4.4A)
None
None
MAL  A 194 (-2.9A)
MAL  A 194 (-2.9A)
 1.24A 3tbgA-3l2jA:
undetectable		 3tbgA-3l2jA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2t PROBABLE
DEHYDROGENASE

(Chromobacterium
violaceum) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 184
PHE A 188
LEU A 135
GLY A 289
PHE A 128
 None
 1.36A 3tbgA-3m2tA:
undetectable		 3tbgA-3m2tA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		5 LEU A 320
LEU A 326
GLY A  64
LEU A  66
SER A 125
 None
 1.35A 3tbgA-3mc2A:
undetectable		 3tbgA-3mc2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oce FUMARATE LYASE:DELTA
CRYSTALLIN

(Brucella
abortus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 PHE A 276
LEU A 152
GLY A 376
LEU A 375
GLN A 158
 None
 1.28A 3tbgA-3oceA:
undetectable		 3tbgA-3oceA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olm E3 UBIQUITIN-PROTEIN
LIGASE RSP5

(Saccharomyces
cerevisiae) 		PF00397
(WW)
PF00632
(HECT) 		5 PHE A 512
PHE A 504
LEU A 507
GLY A 666
PHE A 667
 None
 1.23A 3tbgA-3olmA:
undetectable		 3tbgA-3olmA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		5 PHE A 525
GLY A 595
LEU A 594
GLN A 596
PHE A 608
 None
 1.34A 3tbgA-3s51A:
2.2		 3tbgA-3s51A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6r ANTIBODY 1:7 (LIGHT
CHAIN)

(Homo sapiens) 		no annotation 5 PHE L 210
GLY L 164
LEU L 226
GLU L 227
SER L 224
 None
 1.35A 3tbgA-3u6rL:
undetectable		 3tbgA-3u6rL:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		5 LEU A 203
GLY A 173
LEU A 172
GLU A 133
ASP A 102
 SAM  A 501 (-4.6A)
None
None
SAM  A 501 (-2.3A)
SAM  A 501 ( 4.9A)
 1.04A 3tbgA-3vywA:
undetectable		 3tbgA-3vywA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		5 LEU A 545
PHE A 123
GLY A 558
LEU A 560
GLU A 456
 None
 1.11A 3tbgA-3w5fA:
undetectable		 3tbgA-3w5fA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 249
PHE A 253
LEU A 196
GLY A 266
PHE A 287
 None
 1.22A 3tbgA-4aguA:
undetectable		 3tbgA-4aguA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum) 		PF04054
(Not1) 		5 LEU A1758
PHE A1687
GLY A1791
LEU A1793
PHE A1811
 None
 1.29A 3tbgA-4c0eA:
2.9		 3tbgA-4c0eA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		5 LEU I 575
LEU I 582
GLY I 232
LEU I 231
GLN I 221
 None
 1.26A 3tbgA-4c1nI:
undetectable		 3tbgA-4c1nI:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he8 NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 8

(Thermus
thermophilus) 		no annotation 5 PHE H  97
LEU H  24
PHE H 290
SER H 256
PHE H 280
 None
 1.28A 3tbgA-4he8H:
undetectable		 3tbgA-4he8H:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 LEU M  67
LEU M  70
GLY M 108
LEU M 109
PHE M  65
 None
 1.25A 3tbgA-4heaM:
undetectable		 3tbgA-4heaM:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 LEU N 334
LEU M 160
PHE M 122
SER M 156
PHE N 349
 None
 1.32A 3tbgA-4heaN:
undetectable		 3tbgA-4heaN:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgz CCBJ

(Streptomyces
caelestis) 		PF13649
(Methyltransf_25) 		5 LEU A 216
LEU A 151
GLY A 125
LEU A 124
GLN A 129
 None
None
SO4  A 302 (-3.0A)
None
None
 1.35A 3tbgA-4hgzA:
undetectable		 3tbgA-4hgzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irf MALARIAL CLPB2
ATPASE/HSP101
PROTEIN

(Plasmodium
falciparum) 		PF02861
(Clp_N) 		5 LEU A 145
PHE A  54
LEU A  53
GLY A 120
LEU A 121
 None
 1.29A 3tbgA-4irfA:
undetectable		 3tbgA-4irfA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN

(Helicobacter
pylori) 		PF01497
(Peripla_BP_2) 		5 LEU A 119
GLY A  43
GLN A  45
PHE A  42
SER A 142
 None
 1.32A 3tbgA-4ls3A:
undetectable		 3tbgA-4ls3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4op4 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Vibrio cholerae) 		PF01546
(Peptidase_M20) 		5 LEU A 106
LEU A  29
GLY A  98
ASP A  23
SER A  18
 None
 1.20A 3tbgA-4op4A:
undetectable		 3tbgA-4op4A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 LEU A 115
GLY A 271
LEU A 272
GLU A 269
SER A 276
 None
 1.14A 3tbgA-4pc9A:
undetectable		 3tbgA-4pc9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qa9 EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		5 LEU A 375
PHE A 371
GLY A 193
SER A 180
PHE A 347
 None
None
None
None
EDO  A 405 (-2.3A)
 1.31A 3tbgA-4qa9A:
undetectable		 3tbgA-4qa9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkr THIAMINE TRANSPORTER
THIA

(Listeria
monocytogenes) 		PF09515
(Thia_YuaJ) 		5 PHE A 183
LEU A 175
GLY A  38
LEU A  37
SER A 168
 None
 0.97A 3tbgA-4tkrA:
undetectable		 3tbgA-4tkrA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5
CHITIN BIOSYNTHESIS
PROTEIN CHS6

(Saccharomyces
cerevisiae) 		PF00533
(BRCT)
PF09295
(ChAPs)
PF16893
(fn3_2) 		5 LEU B 340
PHE B 346
LEU B 347
LEU A  71
GLN A  67
 None
 1.28A 3tbgA-4yg8B:
undetectable		 3tbgA-4yg8B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5p CYTOCHROME P450
HYDROXYLASE

(Streptomyces
atroolivaceus) 		PF00067
(p450) 		5 LEU A 374
LEU A 372
GLY A 246
LEU A 245
PHE A 120
 None
 1.16A 3tbgA-4z5pA:
28.7		 3tbgA-4z5pA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8z UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 5 LEU A 129
PHE A 147
GLY A 185
LEU A 208
PHE A 283
 None
 1.28A 3tbgA-4z8zA:
undetectable		 3tbgA-4z8zA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpi PUTATIVE
OXIDASE/HYDROXYLASE

(Streptomyces
hygroscopicus) 		PF05721
(PhyH) 		5 LEU A 199
PHE A  12
GLY A 223
LEU A  86
PHE A 229
 None
 1.35A 3tbgA-4zpiA:
undetectable		 3tbgA-4zpiA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A 865
LEU A 608
GLY A 511
PHE A 508
SER A 601
 None
 1.31A 3tbgA-5a0zA:
2.5		 3tbgA-5a0zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		5 LEU A 447
LEU A 260
GLY A 134
LEU A 133
GLN A 424
 None
HEM  A 501 ( 4.4A)
None
None
None
 1.12A 3tbgA-5c2iA:
undetectable		 3tbgA-5c2iA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		5 PHE D 156
GLY D 300
LEU D 299
GLU D 111
ASP D  14
 None
 1.28A 3tbgA-5disD:
undetectable		 3tbgA-5disD:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjv VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		PF00520
(Ion_trans)
PF08763
(Ca_chan_IQ)
PF16905
(GPHH) 		5 LEU A1020
LEU A 604
GLN A 602
PHE A 597
SER A 606
 None
PC1  A1914 ( 4.3A)
None
None
None
 1.36A 3tbgA-5gjvA:
2.6		 3tbgA-5gjvA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 LEU A 279
GLY A 137
LEU A 139
PHE A  89
SER A  86
 None
 1.25A 3tbgA-5ikpA:
undetectable		 3tbgA-5ikpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuf BIFUNCTIONAL
OLIGORIBONUCLEASE
AND PAP PHOSPHATASE
NRNA

(Bacillus
subtilis) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 LEU A  57
PHE A  59
PHE A 187
LEU A 186
PHE A 160
 None
 1.08A 3tbgA-5iufA:
undetectable		 3tbgA-5iufA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		5 LEU A  62
PHE A  66
PHE A 286
GLY A 112
LEU A 136
 None
 1.34A 3tbgA-5jzbA:
undetectable		 3tbgA-5jzbA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00291
(PALP) 		5 LEU B  79
GLY B 340
LEU B 343
PHE B 341
SER B 345
 None
 1.21A 3tbgA-5kinB:
undetectable		 3tbgA-5kinB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kl0 PHOSPHOGLUCOMUTASE

(Xanthomonas
citri) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 192
PHE A 216
LEU A 208
LEU A 364
PHE A 267
 None
 1.30A 3tbgA-5kl0A:
undetectable		 3tbgA-5kl0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kl0 PHOSPHOGLUCOMUTASE

(Xanthomonas
citri) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 192
PHE A 216
LEU A 212
LEU A 364
PHE A 267
 None
 1.34A 3tbgA-5kl0A:
undetectable		 3tbgA-5kl0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00146
(NADHdh)
PF00499
(Oxidored_q3)
PF00507
(Oxidored_q4) 		5 LEU H 298
GLY J 158
LEU J 161
GLU A  68
SER A 101
 None
 1.25A 3tbgA-5lc5H:
undetectable		 3tbgA-5lc5H:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00146
(NADHdh)
PF00499
(Oxidored_q3) 		5 LEU H 241
LEU H 151
GLY H 101
LEU H 100
PHE J  51
 None
 1.03A 3tbgA-5lc5H:
undetectable		 3tbgA-5lc5H:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8

(Caenorhabditis
elegans) 		PF10220
(Smg8_Smg9) 		5 LEU E 295
LEU E  45
GLY E  26
LEU E  75
ASP E  70
 None
None
None
None
EDO  E 501 (-4.7A)
 1.28A 3tbgA-5nkmE:
undetectable		 3tbgA-5nkmE:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o27 NEUROGLOBIN

(Mus musculus) 		no annotation 5 LEU A  38
PHE A  42
GLY A 110
LEU A 113
PHE A 106
 HEM  A 201 ( 4.7A)
HEM  A 201 (-3.8A)
None
XE  A 206 ( 4.5A)
XE  A 211 (-4.3A)
 1.19A 3tbgA-5o27A:
undetectable		 3tbgA-5o27A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okl AFAMIN

(Homo sapiens) 		no annotation 5 LEU A 530
LEU A 414
GLY A 405
LEU A 406
PHE A 437
 None
 1.34A 3tbgA-5oklA:
3.2		 3tbgA-5oklA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		5 LEU A 486
PHE A 492
LEU A 493
LEU A 443
GLN A 442
 None
None
EDO  A 814 (-3.7A)
None
None
 1.35A 3tbgA-5ul4A:
2.3		 3tbgA-5ul4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v91 FOSFOMYCIN
RESISTANCE PROTEIN

(Klebsiella
pneumoniae) 		PF00903
(Glyoxalase) 		5 LEU A   8
PHE A  21
LEU A 114
ASP A 106
PHE A  80
 None
 1.35A 3tbgA-5v91A:
undetectable		 3tbgA-5v91A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgj 1FD6-V1V2-WITO

(Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF01378
(IgG_binding_B) 		5 LEU G 193
GLY G 240
LEU G 241
GLU G 239
PHE G 159
 None
NAG  G1600 (-3.9A)
None
None
None
 1.34A 3tbgA-5vgjG:
undetectable		 3tbgA-5vgjG:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		5 LEU A 509
GLY A 469
LEU A 470
PHE A 468
PHE A 484
 None
 1.34A 3tbgA-5vylA:
2.1		 3tbgA-5vylA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w19 TRYPTOPHANASE

(Proteus
vulgaris) 		no annotation 5 GLY A 315
LEU A 269
GLN A 314
ASP A  59
SER A  58
 None
 1.34A 3tbgA-5w19A:
undetectable		 3tbgA-5w19A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1k CR1-10 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 LEU D  65
GLY D  46
LEU D  47
GLU D  48
ASP D  91
 None
 1.25A 3tbgA-5w1kD:
undetectable		 3tbgA-5w1kD:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2l CST COMPLEX SUBUNIT
CTC1

(Homo sapiens) 		no annotation 5 LEU A 798
PHE A 800
LEU A 811
LEU A 732
PHE A 830
 None
 1.34A 3tbgA-5w2lA:
undetectable		 3tbgA-5w2lA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 5 GLY A 451
LEU A 452
GLU A 453
ASP A1017
SER A1015
 None
 1.24A 3tbgA-5xgjA:
undetectable		 3tbgA-5xgjA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn7 PUTATIVE RTX-TOXIN

(Vibrio
vulnificus) 		PF11647
(MLD) 		5 LEU A2480
GLY A2433
GLU A2432
GLN A2483
ASP A2502
 None
 1.26A 3tbgA-5xn7A:
undetectable		 3tbgA-5xn7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 5 LEU A 789
PHE A 706
GLY A 750
LEU A 747
SER A 755
 None
 1.06A 3tbgA-5xqoA:
undetectable		 3tbgA-5xqoA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 LEU A 483
PHE A 500
LEU A 283
GLY A 300
LEU A 302
 None
 1.25A 3tbgA-5ykbA:
undetectable		 3tbgA-5ykbA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysb LIN1841 PROTEIN

(Listeria
innocua) 		no annotation 5 PHE A 152
GLY A 300
LEU A 299
SER A 297
PHE A 126
 None
 1.32A 3tbgA-5ysbA:
undetectable		 3tbgA-5ysbA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2

(Homo sapiens) 		no annotation 5 LEU A 137
PHE A 138
GLY A 198
LEU A 178
PHE A 325
 None
 1.19A 3tbgA-6apjA:
undetectable		 3tbgA-6apjA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bb4 MOUSE MONOCLONAL
ANTIBODY C5.2 FAB
LIGHT CHAIN

(Mus musculus) 		no annotation 5 PHE L  62
GLY L  16
LEU L  78
GLU L  79
SER L  76
 None
 1.32A 3tbgA-6bb4L:
undetectable		 3tbgA-6bb4L:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 LEU A1429
LEU A1445
GLY A1469
LEU A1472
PHE A1475
 None
 1.30A 3tbgA-6ez8A:
undetectable		 3tbgA-6ez8A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi) 		no annotation 5 LEU A 149
PHE A 152
PHE A 112
LEU A 120
LEU A  41
 LOH  A 150 ( 4.3A)
None
None
None
None
 1.30A 3tbgA-6ftlA:
undetectable		 3tbgA-6ftlA:
13.10