SIMILAR PATTERNS OF AMINO ACIDS FOR 3T8N_D_EDTD135

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aqz RESTRICTOCIN

(Aspergillus
restrictus) 		no annotation 5 GLY A 117
PRO A 118
PRO A 116
THR A  98
PRO A  97
 None
 1.48A 3t8nD-1aqzA:
0.0
3t8nF-1aqzA:
0.2		 3t8nD-1aqzA:
22.15
3t8nF-1aqzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aqz RESTRICTOCIN

(Aspergillus
restrictus) 		no annotation 5 THR A  98
PRO A  97
GLY A 117
PRO A 118
PRO A 116
 None
 1.48A 3t8nD-1aqzA:
0.0
3t8nF-1aqzA:
0.2		 3t8nD-1aqzA:
22.15
3t8nF-1aqzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3j NADP(H)-DEPENDENT
KETOSE REDUCTASE

(Bemisia
argentifolii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A 118
PRO A 120
THR A 114
GLY A  93
PRO A  92
 None
 1.47A 3t8nD-1e3jA:
0.0
3t8nF-1e3jA:
0.0		 3t8nD-1e3jA:
17.61
3t8nF-1e3jA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 THR A  49
PRO A  50
THR A 300
GLY A 288
ARG A 326
 None
 1.47A 3t8nD-1kyiA:
0.0
3t8nF-1kyiA:
0.0		 3t8nD-1kyiA:
15.28
3t8nF-1kyiA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 THR A 300
GLY A 288
ARG A 326
THR A  49
PRO A  50
 None
 1.48A 3t8nD-1kyiA:
0.0
3t8nF-1kyiA:
0.0		 3t8nD-1kyiA:
15.28
3t8nF-1kyiA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vav ALGINATE LYASE
PA1167

(Pseudomonas
aeruginosa) 		PF08787
(Alginate_lyase2) 		5 GLY A 210
PRO A  93
GLY A  49
PRO A  58
ASP A 202
 None
 1.01A 3t8nD-1vavA:
0.0
3t8nF-1vavA:
undetectable		 3t8nD-1vavA:
19.48
3t8nF-1vavA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		5 THR A  63
GLY A  61
GLY A  35
PRO A  36
ASP A  53
 None
None
None
None
MG  A 500 (-3.2A)
 1.42A 3t8nD-1w25A:
undetectable
3t8nF-1w25A:
0.0		 3t8nD-1w25A:
14.57
3t8nF-1w25A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6v UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15

(Homo sapiens) 		PF06337
(DUSP) 		5 THR A  94
GLY A  96
PRO A  93
ARG A  25
ASP A  15
 None
 1.15A 3t8nD-1w6vA:
0.0
3t8nF-1w6vA:
undetectable		 3t8nD-1w6vA:
17.83
3t8nF-1w6vA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		5 GLY A 130
GLY A 152
PRO A 151
PRO A 182
ASP A 425
 GLN  A 501 (-3.2A)
None
None
None
GLN  A 501 (-2.6A)
 1.39A 3t8nD-2f2aA:
0.0
3t8nF-2f2aA:
0.0		 3t8nD-2f2aA:
13.88
3t8nF-2f2aA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 THR A 446
GLY A 445
PRO A 439
PRO A 437
ASP A 452
 None
 1.47A 3t8nD-2ipiA:
0.0
3t8nF-2ipiA:
0.0		 3t8nD-2ipiA:
12.48
3t8nF-2ipiA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nuj THIOESTERASE
SUPERFAMILY

(Jannaschia) 		PF13279
(4HBT_2) 		5 THR A  97
GLY A  98
PRO A  21
PRO A  23
ASP A 156
 None
 1.37A 3t8nD-2nujA:
0.0
3t8nF-2nujA:
0.9		 3t8nD-2nujA:
23.93
3t8nF-2nujA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcv PUTATIVE
5-DEHYDRO-2-DEOXYGLU
CONOKINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		5 GLY A  17
PRO A  46
THR A 146
GLY A 145
ASP A 122
 None
 1.48A 3t8nD-2qcvA:
undetectable
3t8nF-2qcvA:
undetectable		 3t8nD-2qcvA:
16.87
3t8nF-2qcvA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		5 THR A 572
GLY A 571
PRO A 570
GLY A 362
ASP A 417
 None
 1.24A 3t8nD-2w20A:
0.2
3t8nF-2w20A:
undetectable		 3t8nD-2w20A:
15.27
3t8nF-2w20A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		5 GLY A 462
PRO A 491
GLY A 456
PRO A 455
ASP A 464
 None
 1.50A 3t8nD-2xsgA:
2.1
3t8nF-2xsgA:
2.1		 3t8nD-2xsgA:
10.66
3t8nF-2xsgA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 THR A 117
GLY A 111
THR A 143
GLY A 145
PRO A 146
 None
 1.31A 3t8nD-2z8zA:
undetectable
3t8nF-2z8zA:
undetectable		 3t8nD-2z8zA:
12.24
3t8nF-2z8zA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 THR A 143
GLY A 145
PRO A 146
THR A 117
GLY A 111
 None
 1.30A 3t8nD-2z8zA:
undetectable
3t8nF-2z8zA:
undetectable		 3t8nD-2z8zA:
12.24
3t8nF-2z8zA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		5 GLY A 253
PRO A 254
ARG A 345
GLY A 281
ASP A 346
 None
 1.30A 3t8nD-3a18A:
undetectable
3t8nF-3a18A:
undetectable		 3t8nD-3a18A:
17.22
3t8nF-3a18A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 PRO A 202
THR A 470
GLY A 471
ARG A 431
ASP A 285
 None
 1.46A 3t8nD-3ahiA:
undetectable
3t8nF-3ahiA:
undetectable		 3t8nD-3ahiA:
11.04
3t8nF-3ahiA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima;
Thermotoga
maritima) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 PRO B  50
PRO B  52
THR A 226
PRO B 283
ASP B 281
 None
 1.13A 3t8nD-3al0B:
undetectable
3t8nF-3al0B:
undetectable		 3t8nD-3al0B:
12.89
3t8nF-3al0B:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 THR A 889
GLY A 861
PRO A 890
PRO A 936
ASP A 858
 None
 1.43A 3t8nD-3decA:
undetectable
3t8nF-3decA:
undetectable		 3t8nD-3decA:
7.63
3t8nF-3decA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		5 THR A 390
GLY A 391
THR A 606
GLY A 605
ASP A 623
 None
 1.12A 3t8nD-3e1sA:
undetectable
3t8nF-3e1sA:
undetectable		 3t8nD-3e1sA:
13.76
3t8nF-3e1sA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efv PUTATIVE
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Salmonella
enterica) 		PF00171
(Aldedh) 		5 PRO A 300
PRO A 309
THR A  16
GLY A  17
ASP A 299
 None
 1.36A 3t8nD-3efvA:
undetectable
3t8nF-3efvA:
undetectable		 3t8nD-3efvA:
16.04
3t8nF-3efvA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flt SAP-LIKE PENTRAXIN

(Limulus
polyphemus) 		PF00354
(Pentaxin) 		5 GLY A 143
THR A  14
GLY A  13
PRO A  12
PRO A  20
 None
 1.34A 3t8nD-3fltA:
undetectable
3t8nF-3fltA:
undetectable		 3t8nD-3fltA:
16.74
3t8nF-3fltA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flt SAP-LIKE PENTRAXIN

(Limulus
polyphemus) 		PF00354
(Pentaxin) 		5 THR A  14
GLY A  13
PRO A  12
PRO A  20
GLY A 143
 None
 1.33A 3t8nD-3fltA:
undetectable
3t8nF-3fltA:
undetectable		 3t8nD-3fltA:
16.74
3t8nF-3fltA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 GLY A 113
THR A 101
GLY A 215
ARG A 207
PRO A 214
 None
 1.39A 3t8nD-3kd8A:
undetectable
3t8nF-3kd8A:
undetectable		 3t8nD-3kd8A:
15.91
3t8nF-3kd8A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kda CFTR INHIBITORY
FACTOR (CIF)

(Pseudomonas
aeruginosa) 		no annotation 5 PRO D  89
THR D  99
GLY D 100
PRO D  97
ASP D  42
 None
 1.15A 3t8nD-3kdaD:
undetectable
3t8nF-3kdaD:
undetectable		 3t8nD-3kdaD:
17.45
3t8nF-3kdaD:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		5 ARG A 266
GLY A 332
PRO A 331
PRO A 263
ASP A 261
 None
 1.49A 3t8nD-3lkbA:
undetectable
3t8nF-3lkbA:
undetectable		 3t8nD-3lkbA:
16.89
3t8nF-3lkbA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA
SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 GLY A 177
PRO A 178
GLY A 104
ARG B  83
ASP A 187
 SF4  A 575 ( 4.2A)
None
None
SRM  B 570 (-2.9A)
None
 1.41A 3t8nD-3mm5A:
undetectable
3t8nF-3mm5A:
undetectable		 3t8nD-3mm5A:
15.24
3t8nF-3mm5A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 THR A 808
GLY A 809
PRO A 810
GLY A 579
PRO A 578
 None
 1.28A 3t8nD-3ne5A:
undetectable
3t8nF-3ne5A:
undetectable		 3t8nD-3ne5A:
7.44
3t8nF-3ne5A:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 THR A 413
PRO A 415
GLY A  20
PRO A  19
ASP A 416
 None
 1.45A 3t8nD-3nvsA:
undetectable
3t8nF-3nvsA:
undetectable		 3t8nD-3nvsA:
14.92
3t8nF-3nvsA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE

(Shewanella
baltica) 		PF01182
(Glucosamine_iso) 		5 PRO A 147
THR A 169
PRO A 171
ARG A 174
PRO A 167
 None
 1.26A 3t8nD-3nwpA:
undetectable
3t8nF-3nwpA:
undetectable		 3t8nD-3nwpA:
23.08
3t8nF-3nwpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE

(Shewanella
baltica) 		PF01182
(Glucosamine_iso) 		5 THR A 169
PRO A 171
ARG A 174
PRO A 167
PRO A 147
 None
 1.26A 3t8nD-3nwpA:
undetectable
3t8nF-3nwpA:
undetectable		 3t8nD-3nwpA:
23.08
3t8nF-3nwpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		5 THR A 263
GLY A 262
PRO A 282
THR A 621
GLY A 622
 None
 1.02A 3t8nD-3ohnA:
undetectable
3t8nF-3ohnA:
undetectable		 3t8nD-3ohnA:
12.50
3t8nF-3ohnA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohn OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher) 		5 THR A 621
GLY A 622
THR A 263
GLY A 262
PRO A 282
 None
 1.01A 3t8nD-3ohnA:
undetectable
3t8nF-3ohnA:
undetectable		 3t8nD-3ohnA:
12.50
3t8nF-3ohnA:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3owu STEROID
DELTA-ISOMERASE

(Pseudomonas
putida) 		PF12680
(SnoaL_2) 		5 THR A  71
GLY A  72
PRO A  73
ARG A  75
PRO A  85
 XCN  A  86 ( 3.7A)
None
None
None
XCN  A  86 ( 3.6A)
 0.21A 3t8nD-3owuA:
24.5
3t8nF-3owuA:
24.9		 3t8nD-3owuA:
94.66
3t8nF-3owuA:
94.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3owu STEROID
DELTA-ISOMERASE

(Pseudomonas
putida) 		PF12680
(SnoaL_2) 		6 THR A  71
GLY A  72
PRO A  73
ARG A  75
PRO A  85
ASP A 100
 XCN  A  86 ( 3.7A)
None
None
None
XCN  A  86 ( 3.6A)
None
 0.26A 3t8nD-3owuA:
24.5
3t8nF-3owuA:
24.9		 3t8nD-3owuA:
94.66
3t8nF-3owuA:
94.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t12 GLIDING PROTEIN MGLA

(Thermus
thermophilus) 		PF00025
(Arf) 		5 THR A  26
GLY A  24
GLY A  81
PRO A  80
ASP A 104
 MG  A 198 ( 3.1A)
GDP  A 197 (-3.2A)
ALF  A 200 (-3.6A)
ALF  A 200 (-4.9A)
None
 1.30A 3t8nD-3t12A:
undetectable
3t8nF-3t12A:
undetectable		 3t8nD-3t12A:
19.70
3t8nF-3t12A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc9 HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		5 GLY A 155
PRO A 156
GLY A 162
ARG A 189
ASP A 158
 None
None
None
EDO  A 492 (-3.5A)
None
 1.36A 3t8nD-3tc9A:
undetectable
3t8nF-3tc9A:
undetectable		 3t8nD-3tc9A:
15.68
3t8nF-3tc9A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX

(Homo sapiens) 		PF03097
(BRO1) 		5 THR A 369
THR A  25
GLY A  26
PRO A  27
ASP A 374
 None
 1.32A 3t8nD-3um1A:
undetectable
3t8nF-3um1A:
undetectable		 3t8nD-3um1A:
16.37
3t8nF-3um1A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		5 THR A  20
GLY A  21
THR A 143
GLY A 144
PRO A 145
 FAD  A 551 (-3.2A)
None
FAD  A 551 ( 4.3A)
FAD  A 551 (-3.3A)
FAD  A 551 ( 4.3A)
 0.96A 3t8nD-3up4A:
undetectable
3t8nF-3up4A:
undetectable		 3t8nD-3up4A:
13.94
3t8nF-3up4A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida) 		PF00743
(FMO-like) 		5 THR A 143
GLY A 144
PRO A 145
THR A  20
GLY A  21
 FAD  A 551 ( 4.3A)
FAD  A 551 (-3.3A)
FAD  A 551 ( 4.3A)
FAD  A 551 (-3.2A)
None
 0.97A 3t8nD-3up4A:
undetectable
3t8nF-3up4A:
undetectable		 3t8nD-3up4A:
13.94
3t8nF-3up4A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 THR A 410
PRO A 412
ARG A 638
THR A 324
GLY A 334
 None
 1.22A 3t8nD-3wkyA:
undetectable
3t8nF-3wkyA:
undetectable		 3t8nD-3wkyA:
12.46
3t8nF-3wkyA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqq INTEGRASE

(Streptomyces
virus phiC31) 		PF00239
(Resolvase) 		5 THR A 206
GLY A 207
PRO A 208
PRO A 257
ASP A 254
 None
 1.25A 3t8nD-4bqqA:
undetectable
3t8nF-4bqqA:
undetectable		 3t8nD-4bqqA:
15.74
3t8nF-4bqqA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyk AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 THR A 323
GLY A 321
THR A 308
GLY A 307
ASP A 316
 None
None
None
None
MG  A 502 (-2.7A)
 1.36A 3t8nD-4dykA:
undetectable
3t8nF-4dykA:
undetectable		 3t8nD-4dykA:
15.08
3t8nF-4dykA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 GLY A 151
PRO A 150
PRO A 154
PRO A 172
ASP A 176
 None
 1.37A 3t8nD-4e4gA:
undetectable
3t8nF-4e4gA:
undetectable		 3t8nD-4e4gA:
14.79
3t8nF-4e4gA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 THR A 270
PRO A 272
THR A 365
GLY A 364
ARG A 310
 None
None
15P  A 504 (-3.9A)
None
None
 1.22A 3t8nD-4grhA:
undetectable
3t8nF-4grhA:
undetectable		 3t8nD-4grhA:
15.38
3t8nF-4grhA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 THR A 365
GLY A 364
ARG A 310
THR A 270
PRO A 272
 15P  A 504 (-3.9A)
None
None
None
None
 1.24A 3t8nD-4grhA:
undetectable
3t8nF-4grhA:
undetectable		 3t8nD-4grhA:
15.38
3t8nF-4grhA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 THR A 590
GLY A 589
PRO A 588
THR A 443
ASP A 575
 SO4  A 904 (-4.5A)
None
None
None
None
 1.15A 3t8nD-4i3gA:
undetectable
3t8nF-4i3gA:
undetectable		 3t8nD-4i3gA:
11.22
3t8nF-4i3gA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		5 THR A 101
GLY A 102
PRO A 156
THR A 186
GLY A 183
 None
 1.39A 3t8nD-4iheA:
undetectable
3t8nF-4iheA:
undetectable		 3t8nD-4iheA:
14.01
3t8nF-4iheA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihe THNT PROTEIN

(Streptomyces
cattleya) 		PF03576
(Peptidase_S58) 		5 THR A 186
GLY A 183
THR A 101
GLY A 102
PRO A 156
 None
 1.39A 3t8nD-4iheA:
undetectable
3t8nF-4iheA:
undetectable		 3t8nD-4iheA:
14.01
3t8nF-4iheA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		5 PRO A 294
PRO A 303
THR A  10
GLY A  11
ASP A 293
 None
 1.37A 3t8nD-4itaA:
undetectable
3t8nF-4itaA:
undetectable		 3t8nD-4itaA:
15.07
3t8nF-4itaA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		5 THR A 231
GLY A  90
GLY A 212
PRO A 213
ASP A  96
 None
 1.31A 3t8nD-4j3qA:
undetectable
3t8nF-4j3qA:
undetectable		 3t8nD-4j3qA:
18.28
3t8nF-4j3qA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k12 COMPLEMENT FACTOR H

(Homo sapiens) 		PF00084
(Sushi) 		5 THR A  44
GLY A  45
THR A  40
GLY A  41
ASP A  56
 None
 1.32A 3t8nD-4k12A:
undetectable
3t8nF-4k12A:
undetectable		 3t8nD-4k12A:
14.50
3t8nF-4k12A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oig NON-STRUCTURAL
PROTEIN 1, NS1

(Dengue virus) 		PF00948
(Flavi_NS1) 		5 GLY A 295
ARG A 294
THR A 264
GLY A 266
PRO A 267
 None
 1.22A 3t8nD-4oigA:
undetectable
3t8nF-4oigA:
undetectable		 3t8nD-4oigA:
21.93
3t8nF-4oigA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oig NON-STRUCTURAL
PROTEIN 1, NS1

(Dengue virus) 		PF00948
(Flavi_NS1) 		5 THR A 264
GLY A 266
PRO A 267
GLY A 295
ARG A 294
 None
 1.22A 3t8nD-4oigA:
undetectable
3t8nF-4oigA:
undetectable		 3t8nD-4oigA:
21.93
3t8nF-4oigA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 THR A 784
GLY A 785
GLY A 780
PRO A 781
ARG A 713
 None
None
PT  A 912 ( 4.6A)
PT  A 912 ( 4.0A)
None
 1.26A 3t8nD-4qi7A:
undetectable
3t8nF-4qi7A:
1.1		 3t8nD-4qi7A:
10.07
3t8nF-4qi7A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raa PUTATIVE EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF17170
(DUF5128) 		5 PRO A 249
THR A 204
GLY A 205
PRO A 206
PRO A 222
 None
 1.24A 3t8nD-4raaA:
undetectable
3t8nF-4raaA:
0.7		 3t8nD-4raaA:
15.43
3t8nF-4raaA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raa PUTATIVE EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF17170
(DUF5128) 		5 THR A 204
GLY A 205
PRO A 206
PRO A 222
PRO A 249
 None
 1.24A 3t8nD-4raaA:
undetectable
3t8nF-4raaA:
0.7		 3t8nD-4raaA:
15.43
3t8nF-4raaA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 THR A 628
GLY A 638
THR A  52
ARG A 668
ASP A 664
 None
 1.37A 3t8nD-5fp1A:
1.3
3t8nF-5fp1A:
1.3		 3t8nD-5fp1A:
10.32
3t8nF-5fp1A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gva WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 THR A  13
THR A  17
GLY A  32
ARG A  38
ASP A 292
 None
 1.50A 3t8nD-5gvaA:
undetectable
3t8nF-5gvaA:
undetectable		 3t8nD-5gvaA:
17.70
3t8nF-5gvaA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it0 PHOSPHOSERINE
PHOSPHATASE

(Mycobacterium
avium) 		PF12710
(HAD)
PF13740
(ACT_6) 		5 GLY A 256
PRO A 255
THR A 381
ARG A 390
PRO A 136
 None
 1.34A 3t8nD-5it0A:
undetectable
3t8nF-5it0A:
undetectable		 3t8nD-5it0A:
16.67
3t8nF-5it0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it0 PHOSPHOSERINE
PHOSPHATASE

(Mycobacterium
avium) 		PF12710
(HAD)
PF13740
(ACT_6) 		5 THR A 259
GLY A 256
THR A 381
ARG A 390
PRO A 136
 None
 1.25A 3t8nD-5it0A:
undetectable
3t8nF-5it0A:
undetectable		 3t8nD-5it0A:
16.67
3t8nF-5it0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it0 PHOSPHOSERINE
PHOSPHATASE

(Mycobacterium
avium) 		PF12710
(HAD)
PF13740
(ACT_6) 		5 THR A 381
ARG A 390
PRO A 136
GLY A 256
PRO A 255
 None
 1.34A 3t8nD-5it0A:
undetectable
3t8nF-5it0A:
undetectable		 3t8nD-5it0A:
16.67
3t8nF-5it0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it0 PHOSPHOSERINE
PHOSPHATASE

(Mycobacterium
avium) 		PF12710
(HAD)
PF13740
(ACT_6) 		5 THR A 381
ARG A 390
PRO A 136
THR A 259
GLY A 256
 None
 1.26A 3t8nD-5it0A:
undetectable
3t8nF-5it0A:
undetectable		 3t8nD-5it0A:
16.67
3t8nF-5it0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 GLY A 451
THR A 661
GLY A 660
PRO A 659
PRO A 447
 None
 1.41A 3t8nD-5kdxA:
undetectable
3t8nF-5kdxA:
undetectable		 3t8nD-5kdxA:
8.76
3t8nF-5kdxA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		5 THR A 661
GLY A 660
PRO A 659
PRO A 447
GLY A 451
 None
 1.42A 3t8nD-5kdxA:
undetectable
3t8nF-5kdxA:
undetectable		 3t8nD-5kdxA:
8.76
3t8nF-5kdxA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm4 KINESIN-5

(Ustilago maydis) 		no annotation 5 GLY K  26
PRO K  25
THR K  29
GLY K  32
PRO K  33
 None
 1.38A 3t8nD-5mm4K:
undetectable
3t8nF-5mm4K:
0.5		 3t8nD-5mm4K:
undetectable
3t8nF-5mm4K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm4 KINESIN-5

(Ustilago maydis) 		no annotation 5 THR K  29
GLY K  32
PRO K  33
GLY K  26
PRO K  25
 None
 1.37A 3t8nD-5mm4K:
undetectable
3t8nF-5mm4K:
0.5		 3t8nD-5mm4K:
undetectable
3t8nF-5mm4K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mv3 SYNTHETIC PEPTIDE
CONTAINING THE
CII583-591 EPITOPE
OF COLLAGEN TYPE
II,COLLAGEN
ALPHA-1(II)
CHAIN,SYNTHETIC
PEPTIDE CONTAINING
THE CII583-591
EPITOPE OF COLLAGEN
TYPE II,

(Mus musculus) 		no annotation 5 GLY X  13
PRO X  12
THR X  18
GLY X  19
PRO X  20
 None
 1.24A 3t8nD-5mv3X:
undetectable
3t8nF-5mv3X:
undetectable		 3t8nD-5mv3X:
15.27
3t8nF-5mv3X:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mv3 SYNTHETIC PEPTIDE
CONTAINING THE
CII583-591 EPITOPE
OF COLLAGEN TYPE
II,COLLAGEN
ALPHA-1(II)
CHAIN,SYNTHETIC
PEPTIDE CONTAINING
THE CII583-591
EPITOPE OF COLLAGEN
TYPE II,

(Mus musculus) 		no annotation 5 THR X  18
GLY X  19
PRO X  20
GLY X  13
PRO X  12
 None
 1.26A 3t8nD-5mv3X:
undetectable
3t8nF-5mv3X:
undetectable		 3t8nD-5mv3X:
15.27
3t8nF-5mv3X:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 THR A1910
GLY A1909
ARG A2358
THR A1913
ASP A2320
 None
ADP  A4801 (-3.8A)
ADP  A4801 (-2.9A)
ADP  A4801 (-3.8A)
ADP  A4801 (-3.3A)
 1.16A 3t8nD-5nugA:
undetectable
3t8nF-5nugA:
undetectable		 3t8nD-5nugA:
2.56
3t8nF-5nugA:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 THR A1910
GLY A1909
THR A1913
PRO A1904
ASP A2320
 None
ADP  A4801 (-3.8A)
ADP  A4801 (-3.8A)
None
ADP  A4801 (-3.3A)
 1.36A 3t8nD-5nugA:
undetectable
3t8nF-5nugA:
undetectable		 3t8nD-5nugA:
2.56
3t8nF-5nugA:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 5 THR A 231
GLY A  90
GLY A 212
PRO A 213
ASP A  96
 None
 1.34A 3t8nD-5or4A:
undetectable
3t8nF-5or4A:
undetectable		 3t8nD-5or4A:
undetectable
3t8nF-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or7 CAPSID PROTEIN

(Norwalk virus) 		no annotation 5 GLY A 411
THR A 363
GLY A 360
PRO A 361
ASP A 366
 None
None
None
NA  A 601 (-4.6A)
NA  C 401 (-3.7A)
 1.34A 3t8nD-5or7A:
undetectable
3t8nF-5or7A:
undetectable		 3t8nD-5or7A:
undetectable
3t8nF-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB

(Geobacter
metallireducens) 		PF00437
(T2SSE) 		5 PRO A 425
THR A 324
GLY A 325
PRO A 326
ARG A 452
 None
 1.29A 3t8nD-5tshA:
undetectable
3t8nF-5tshA:
undetectable		 3t8nD-5tshA:
12.95
3t8nF-5tshA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB

(Geobacter
metallireducens) 		PF00437
(T2SSE) 		5 THR A 324
GLY A 325
PRO A 326
ARG A 452
PRO A 425
 None
 1.27A 3t8nD-5tshA:
undetectable
3t8nF-5tshA:
undetectable		 3t8nD-5tshA:
12.95
3t8nF-5tshA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv1 BETA-ARRESTIN-2

(Bos taurus) 		no annotation 5 THR A 137
GLY A 138
GLY A 133
PRO A 134
PRO A 132
 None
 1.33A 3t8nD-5tv1A:
undetectable
3t8nF-5tv1A:
undetectable		 3t8nD-5tv1A:
12.79
3t8nF-5tv1A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF00400
(WD40)
PF12937
(F-box-like) 		5 THR B2692
GLY B2691
THR B2695
GLY B2687
ASP B2381
 None
 1.06A 3t8nD-5v4bB:
undetectable
3t8nF-5v4bB:
undetectable		 3t8nD-5v4bB:
13.30
3t8nF-5v4bB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhj 26S PROTEASOME
REGULATORY SUBUNIT
10B

(Homo sapiens) 		PF00004
(AAA) 		5 THR E 178
GLY E 177
PRO E 176
PRO E 304
ASP E 302
 None
 1.02A 3t8nD-5vhjE:
undetectable
3t8nF-5vhjE:
undetectable		 3t8nD-5vhjE:
18.42
3t8nF-5vhjE:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7k ENDO-ALPHA-(1->5)-L-
ARABINANASE

(Bacillus
licheniformis) 		no annotation 5 THR A 218
THR A 221
GLY A 222
PRO A 223
ASP A 136
 None
 1.47A 3t8nD-6b7kA:
undetectable
3t8nF-6b7kA:
undetectable		 3t8nD-6b7kA:
undetectable
3t8nF-6b7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 5 PRO A1706
THR A2044
GLY A2045
ARG A1856
ASP A1707
 None
 1.10A 3t8nD-6bq1A:
undetectable
3t8nF-6bq1A:
undetectable		 3t8nD-6bq1A:
undetectable
3t8nF-6bq1A:
undetectable