SIMILAR PATTERNS OF AMINO ACIDS FOR 3T7V_A_SAMA992_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am5 PEPSIN

(Gadus morhua) 		PF00026
(Asp) 		5 THR A 218
GLY A  34
LEU A 194
VAL A 222
ALA A 223
 None
 1.14A 3t7vA-1am5A:
undetectable		 3t7vA-1am5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4
BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4
BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E;
Enterovirus E;
Enterovirus E) 		PF00073
(Rhv)
PF00073
(Rhv)
PF00073
(Rhv) 		5 THR 2 121
GLY 3 121
GLY 3 213
GLN 3 160
ALA 1  40
 None
 1.12A 3t7vA-1bev2:
undetectable		 3t7vA-1bev2:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 THR A 419
GLY A 656
TYR A 425
VAL A 391
ALA A 392
 None
MCN  A 914 (-4.4A)
None
None
None
 0.94A 3t7vA-1dgjA:
undetectable		 3t7vA-1dgjA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqz PROTEIN (ANTIGEN
85-C)

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		5 GLY A 128
GLY A 149
LEU A 269
MET A 272
ALA A 119
 None
 1.14A 3t7vA-1dqzA:
undetectable		 3t7vA-1dqzA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h5y HISF

(Pyrobaculum
aerophilum) 		PF00977
(His_biosynth) 		5 GLY A 167
GLY A 124
LEU A  81
VAL A 130
ALA A 131
 None
None
None
None
GOL  A 401 (-3.4A)
 1.25A 3t7vA-1h5yA:
14.8		 3t7vA-1h5yA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		5 THR A 132
GLY A 128
LEU A 310
MET A 307
ALA A 259
 None
 1.11A 3t7vA-1i41A:
undetectable		 3t7vA-1i41A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iou YKT6P

(Saccharomyces
cerevisiae) 		PF13774
(Longin) 		5 GLY A  52
GLY A  54
TYR A  69
VAL A  47
ALA A  44
 None
 1.24A 3t7vA-1iouA:
undetectable		 3t7vA-1iouA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		5 GLY A 124
GLY A  51
LEU A  38
VAL A 232
ALA A 233
 None
 1.17A 3t7vA-1olpA:
undetectable		 3t7vA-1olpA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2d PURINE TRANS
DEOXYRIBOSYLASE

(Lactobacillus
helveticus) 		PF05014
(Nuc_deoxyrib_tr) 		5 GLY A  85
GLY A  13
TYR A  89
MET A 127
VAL A 135
 None
AR4  A 101 ( 3.4A)
None
None
None
 1.17A 3t7vA-1s2dA:
undetectable		 3t7vA-1s2dA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		5 GLY A 245
GLY A 358
LEU A  68
VAL A 292
ALA A 294
 PG4  A4502 ( 3.7A)
HEM  A1430 ( 3.9A)
HEM  A1430 ( 4.9A)
HEM  A1430 (-4.4A)
None
 1.25A 3t7vA-1uedA:
undetectable		 3t7vA-1uedA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uek 4-(CYTIDINE
5'-DIPHOSPHO)-2C-MET
HYL-D-ERYTHRITOL
KINASE

(Thermus
thermophilus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A  90
GLY A 232
LEU A 225
MET A 220
ALA A 260
 None
 1.21A 3t7vA-1uekA:
undetectable		 3t7vA-1uekA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uou THYMIDINE
PHOSPHORYLASE

(Homo sapiens) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 THR A 154
GLY A 145
GLY A 186
GLU A 225
LEU A 227
 None
 1.09A 3t7vA-1uouA:
undetectable		 3t7vA-1uouA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkg MAJOR MITE FECAL
ALLERGEN DER P 1

(Dermatophagoides
pteronyssinus) 		PF00112
(Peptidase_C1) 		5 GLY A 282
GLY A 277
LEU A  62
VAL A 252
ALA A 251
 None
None
None
None
GOL  A 602 (-3.9A)
 0.96A 3t7vA-1xkgA:
undetectable		 3t7vA-1xkgA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtt PROBABLE URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF14681
(UPRTase) 		5 GLY A  36
GLY A  40
LEU A   3
VAL A 191
ALA A 192
 None
 1.25A 3t7vA-1xttA:
undetectable		 3t7vA-1xttA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsw GLYOXALASE FAMILY
PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		5 GLY A 201
GLY A 158
TYR A 111
ARG A 114
ALA A 190
 None
 1.15A 3t7vA-1zswA:
undetectable		 3t7vA-1zswA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvu TOPOISOMERASE IV
SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV)
PF03989
(DNA_gyraseA_C) 		5 GLY A 168
TYR A  97
LEU A 131
VAL A 188
ALA A 189
 None
 1.23A 3t7vA-1zvuA:
undetectable		 3t7vA-1zvuA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  12
GLY A  10
GLU A 108
VAL A  94
ALA A  95
 FAD  A 480 (-3.5A)
FAD  A 480 (-3.2A)
None
None
None
 1.21A 3t7vA-2a8xA:
undetectable		 3t7vA-2a8xA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 GLY A 497
GLY A 458
LEU A 469
MET A 468
VAL A 491
 None
 1.21A 3t7vA-2b3oA:
undetectable		 3t7vA-2b3oA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 GLY A 828
TYR A 818
GLU A 822
LEU A 819
VAL A 851
 None
 1.23A 3t7vA-2b3xA:
2.2		 3t7vA-2b3xA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgk RHIZOME
SECOISOLARICIRESINOL
DEHYDROGENASE

(Podophyllum
peltatum) 		PF13561
(adh_short_C2) 		5 THR A 151
GLY A  98
GLY A  23
VAL A 240
ALA A 241
 None
 1.12A 3t7vA-2bgkA:
3.3		 3t7vA-2bgkA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bht CYSTEINE SYNTHASE B

(Escherichia
coli) 		PF00291
(PALP) 		5 THR A 152
GLY A 181
GLY A 155
GLU A  32
ALA A  45
 None
 1.23A 3t7vA-2bhtA:
undetectable		 3t7vA-2bhtA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		5 GLY A  55
GLY A  53
GLU A 160
LEU A 163
VAL A 114
 None
 1.25A 3t7vA-2bs9A:
5.6		 3t7vA-2bs9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsx PURINE NUCLEOSIDE
PHOSPHORYLASE

(Plasmodium
falciparum) 		PF01048
(PNP_UDP_1) 		5 GLY A  65
GLY A  70
GLU A  77
LEU A   5
ALA A  42
 None
 1.21A 3t7vA-2bsxA:
undetectable		 3t7vA-2bsxA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bws XAA-PRO
AMINOPEPTIDASE P

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 GLY A  54
GLU A   7
ARG A  11
VAL A 183
ALA A 182
 None
 1.10A 3t7vA-2bwsA:
undetectable		 3t7vA-2bwsA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		5 GLY A  34
GLY A  67
LEU A 108
VAL A  47
ALA A  48
 None
 0.99A 3t7vA-2cdqA:
undetectable		 3t7vA-2cdqA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 GLY A 424
GLY A 401
GLN A 411
VAL A 421
ALA A 414
 None
ADP  A1482 ( 3.9A)
None
None
None
 1.20A 3t7vA-2cgjA:
undetectable		 3t7vA-2cgjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy8 D-PHENYLGLYCINE
AMINOTRANSFERASE

(Pseudomonas
stutzeri) 		PF00202
(Aminotran_3) 		5 GLY A  64
GLY A  67
ARG A 248
LEU A 333
VAL A  49
 None
 1.23A 3t7vA-2cy8A:
undetectable		 3t7vA-2cy8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0i DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 THR A 259
GLY A 237
GLY A 235
LEU A 198
VAL A 245
 None
 1.19A 3t7vA-2d0iA:
undetectable		 3t7vA-2d0iA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 GLY A 702
GLU A 540
LEU A 537
MET A 533
ALA A 484
 None
 1.05A 3t7vA-2e8yA:
4.5		 3t7vA-2e8yA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		5 GLU A  77
LEU A  24
GLN A  81
VAL A  67
ALA A  68
 CD  A 401 (-3.2A)
None
None
None
None
 0.93A 3t7vA-2f91A:
undetectable		 3t7vA-2f91A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcr FLAVODOXIN

(Chondrus
crispus) 		PF00258
(Flavodoxin_1) 		5 GLY A  91
GLY A  52
LEU A  24
VAL A 160
ALA A 161
 None
 1.18A 3t7vA-2fcrA:
undetectable		 3t7vA-2fcrA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		6 GLY A 890
GLY A 877
ARG A 909
LEU A 925
VAL A 897
ALA A 934
 None
 1.37A 3t7vA-2hpiA:
2.9		 3t7vA-2hpiA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Porphyromonas
gingivalis) 		PF00588
(SpoU_methylase) 		5 GLY A 132
GLY A 134
ARG A 207
VAL A 213
ALA A 214
 None
 1.20A 3t7vA-2i6dA:
undetectable		 3t7vA-2i6dA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qny 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Mycobacterium
tuberculosis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 167
LEU A 288
MET A 284
VAL A 315
ALA A 299
 None
 0.94A 3t7vA-2qnyA:
undetectable		 3t7vA-2qnyA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		5 GLY A 278
GLY A 276
LEU A  50
VAL A 203
ALA A  28
 None
 1.09A 3t7vA-2r98A:
undetectable		 3t7vA-2r98A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 GLY A 582
GLY A 576
ARG A 416
VAL A 548
ALA A 547
 None
 1.09A 3t7vA-2vdaA:
undetectable		 3t7vA-2vdaA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 THR A 134
GLY A 401
GLY A 120
ARG A 258
LEU A 315
 None
TEO  A1589 (-3.4A)
None
None
None
 1.20A 3t7vA-2wu5A:
undetectable		 3t7vA-2wu5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		5 GLY A 225
GLY A 217
TYR A  55
GLN A 326
VAL A 184
 None
 1.21A 3t7vA-2x8uA:
2.1		 3t7vA-2x8uA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2x TK-SUBTILISIN

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		5 THR A 327
GLY A 283
GLY A 322
GLU A 265
ALA A 275
 MIS  A 324 ( 4.5A)
None
MIS  A 324 ( 3.2A)
None
None
 1.07A 3t7vA-2z2xA:
2.3		 3t7vA-2z2xA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 GLY A 228
GLY A 259
LEU A 403
VAL A 351
ALA A 352
 None
 1.15A 3t7vA-2zr2A:
undetectable		 3t7vA-2zr2A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		5 GLY A 234
GLY A 231
TYR A 258
LEU A 244
ALA A  65
 None
 1.13A 3t7vA-3c3jA:
undetectable		 3t7vA-3c3jA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLY A  45
TYR A  53
LEU A  59
GLN A 428
ALA A 431
 None
 1.22A 3t7vA-3ce6A:
undetectable		 3t7vA-3ce6A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d02 PUTATIVE LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		5 GLY A 224
GLY A 221
TYR A 140
VAL A 243
ALA A 242
 None
GOL  A   4 ( 3.7A)
None
None
None
 1.24A 3t7vA-3d02A:
undetectable		 3t7vA-3d02A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLY A  28
TYR A  36
LEU A  42
GLN A 364
ALA A 367
 None
 1.16A 3t7vA-3g1uA:
undetectable		 3t7vA-3g1uA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		5 THR A 296
GLY A 229
LEU A 342
VAL A 288
ALA A 287
 U2F  A 547 (-3.6A)
U2F  A 547 (-3.5A)
None
None
None
 1.16A 3t7vA-3h4iA:
undetectable		 3t7vA-3h4iA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlt HDHD2

(Homo sapiens) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 THR A 225
GLY A 203
GLN A  29
VAL A  25
ALA A  24
 None
 1.20A 3t7vA-3hltA:
undetectable		 3t7vA-3hltA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding) 		5 GLY A 103
LEU A 217
GLN A 183
VAL A  77
ALA A  78
 None
 1.20A 3t7vA-3ivrA:
undetectable		 3t7vA-3ivrA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 GLY A  45
GLY A  70
GLN A  40
VAL A  38
ALA A  37
 None
 1.25A 3t7vA-3k5wA:
undetectable		 3t7vA-3k5wA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtj HOMOSERINE
DEHYDROGENASE

(Thiobacillus
denitrificans) 		PF00742
(Homoserine_dh)
PF01842
(ACT)
PF03447
(NAD_binding_3) 		5 GLY A 159
GLY A 299
TYR A 296
LEU A 294
ALA A 274
 None
 1.18A 3t7vA-3mtjA:
undetectable		 3t7vA-3mtjA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1k DIHYDRONEOPTERIN
ALDOLASE FOLB,
PUTATIVE

(Vibrio cholerae) 		PF02152
(FolB) 		5 THR A  25
GLY A  79
LEU A  44
VAL A  87
ALA A  88
 None
 1.12A 3t7vA-3o1kA:
undetectable		 3t7vA-3o1kA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		6 THR A 114
GLY A 116
GLY A 148
TYR A 169
ARG A 190
MET A 237
 MD0  A 993 (-4.0A)
SF4  A 991 ( 3.7A)
SAM  A 992 ( 3.8A)
SAM  A 992 ( 4.6A)
SAM  A 992 (-3.3A)
MD0  A 993 (-3.9A)
 1.03A 3t7vA-3t7vA:
63.9		 3t7vA-3t7vA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		12 THR A 114
GLY A 116
GLY A 148
TYR A 169
GLU A 171
ARG A 182
ARG A 190
LEU A 209
MET A 237
GLN A 242
VAL A 310
ALA A 311
 MD0  A 993 (-4.0A)
SF4  A 991 ( 3.7A)
SAM  A 992 ( 3.8A)
SAM  A 992 ( 4.6A)
SAM  A 992 (-2.8A)
SAM  A 992 ( 2.7A)
SAM  A 992 (-3.3A)
SAM  A 992 (-4.8A)
MD0  A 993 (-3.9A)
SAM  A 992 (-4.2A)
SAM  A 992 (-3.7A)
SAM  A 992 ( 3.8A)
 0.03A 3t7vA-3t7vA:
63.9		 3t7vA-3t7vA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		5 GLY A 309
GLY A 138
GLU A 141
VAL A 341
ALA A 345
 CA0  A 602 ( 4.0A)
CA0  A 602 (-3.1A)
None
None
None
 1.09A 3t7vA-3vexA:
undetectable		 3t7vA-3vexA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		5 GLY A  42
GLY A 340
LEU A  53
VAL A 436
ALA A 419
 None
 1.23A 3t7vA-3zvtA:
undetectable		 3t7vA-3zvtA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 THR A 732
GLY A 244
GLY A 286
VAL A 597
ALA A 601
 None
 1.24A 3t7vA-4a01A:
undetectable		 3t7vA-4a01A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b45 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		5 GLY A 108
GLY A  12
LEU A  86
GLN A  79
ALA A 118
 GSP  A1342 (-4.0A)
None
None
None
None
 0.98A 3t7vA-4b45A:
undetectable		 3t7vA-4b45A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bht NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Escherichia
coli) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 126
GLY A 110
LEU A  51
VAL A 437
ALA A 438
 None
 1.08A 3t7vA-4bhtA:
undetectable		 3t7vA-4bhtA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 775
GLY A 707
LEU A 767
VAL A 746
ALA A 747
 None
 1.18A 3t7vA-4ckrA:
undetectable		 3t7vA-4ckrA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e08 DJ-1 BETA

(Drosophila
melanogaster) 		PF01965
(DJ-1_PfpI) 		5 GLY A  76
GLY A  72
GLN A  50
VAL A  43
ALA A  42
 None
 1.16A 3t7vA-4e08A:
undetectable		 3t7vA-4e08A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY

(Burkholderia
thailandensis) 		PF02636
(Methyltransf_28) 		5 GLY A 187
GLU A 121
LEU A 129
VAL A 107
ALA A 104
 None
 1.24A 3t7vA-4f3nA:
undetectable		 3t7vA-4f3nA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfn ALLYL ALCOHOL
DEHYDROGENASE

(Nicotiana
tabacum) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 GLY A  81
GLY A 104
GLN A 336
VAL A 338
ALA A 314
 None
 1.24A 3t7vA-4hfnA:
undetectable		 3t7vA-4hfnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu9 NITRITE EXTRUSION
PROTEIN 2

(Escherichia
coli) 		no annotation 5 GLY B 306
GLY B 360
TYR B 261
LEU B 257
ALA B 371
 None
 1.03A 3t7vA-4iu9B:
undetectable		 3t7vA-4iu9B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		5 GLY A 447
GLY A 455
LEU A 114
GLN A 443
ALA A 442
 None
None
None
EDO  A 506 ( 4.7A)
EDO  A 506 (-3.6A)
 1.10A 3t7vA-4jz6A:
undetectable		 3t7vA-4jz6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A3064
GLY A3297
LEU A3475
MET A3487
VAL A3060
 None
 1.09A 3t7vA-4kc5A:
undetectable		 3t7vA-4kc5A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmr TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Sanguibacter
keddieii) 		PF13377
(Peripla_BP_3) 		5 GLY A 302
LEU A 129
GLN A  97
VAL A  93
ALA A  94
 None
 1.24A 3t7vA-4kmrA:
undetectable		 3t7vA-4kmrA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nar PUTATIVE URONATE
ISOMERASE

(Thermotoga
maritima) 		PF09861
(DUF2088) 		5 GLY A 358
GLY A 360
TYR A 334
LEU A 339
VAL A 353
 None
 1.11A 3t7vA-4narA:
undetectable		 3t7vA-4narA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nle ADENYLOSUCCINATE
LYASE

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		6 GLY A  99
GLY A 190
ARG A 186
LEU A 220
VAL A  38
ALA A  37
 None
 1.25A 3t7vA-4nleA:
undetectable		 3t7vA-4nleA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5q GLUTATHIONE
S-TRANSFERASE

(Dermatophagoides
pteronyssinus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 GLY A  89
GLY A  82
LEU A 192
MET A 189
ALA A 147
 None
 1.09A 3t7vA-4q5qA:
undetectable		 3t7vA-4q5qA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		5 THR A 398
GLY A 375
LEU A 143
VAL A 174
ALA A 173
 None
 1.22A 3t7vA-4qbuA:
undetectable		 3t7vA-4qbuA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qla JUVENILE HORMONE
EPOXIDE HYDROLASE

(Bombyx mori) 		PF06441
(EHN) 		5 GLY A 188
GLY A 190
LEU A 149
VAL A 205
ALA A 206
 None
 1.14A 3t7vA-4qlaA:
undetectable		 3t7vA-4qlaA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		5 GLY A  90
GLY A  23
LEU A  18
VAL A 242
ALA A 245
 SO4  A 302 (-3.3A)
SO4  A 302 (-3.2A)
None
None
None
 1.24A 3t7vA-4r2wA:
undetectable		 3t7vA-4r2wA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		5 GLY A 142
GLY A 177
GLU A 204
ARG A 230
LEU A 250
 SAH  A 501 (-3.6A)
SAH  A 501 ( 3.9A)
SAH  A 501 (-2.7A)
SAH  A 501 (-2.9A)
SAH  A 501 ( 3.6A)
 0.76A 3t7vA-4r33A:
28.8		 3t7vA-4r33A:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		5 GLY A 142
GLY A 177
GLU A 204
ARG A 230
LEU A 253
 SAH  A 501 (-3.6A)
SAH  A 501 ( 3.9A)
SAH  A 501 (-2.7A)
SAH  A 501 (-2.9A)
None
 1.22A 3t7vA-4r33A:
28.8		 3t7vA-4r33A:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9n LMO0547 PROTEIN

(Listeria
monocytogenes) 		PF04198
(Sugar-bind) 		5 GLY A 295
GLY A 250
LEU A 264
VAL A 275
ALA A 205
 None
 1.19A 3t7vA-4r9nA:
undetectable		 3t7vA-4r9nA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6y NANOBODY NBFEDF9

(Lama glama) 		PF07686
(V-set) 		5 GLY B  10
GLY B   8
GLN B  13
VAL B 127
ALA B  14
 None
 1.11A 3t7vA-4w6yB:
undetectable		 3t7vA-4w6yB:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 GLY A  25
GLY A 428
LEU A 201
VAL A 398
ALA A 204
 None
 1.13A 3t7vA-5a0tA:
2.2		 3t7vA-5a0tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 GLY A  70
GLU A 300
LEU A  95
GLN A 117
ALA A 110
 None
GOL  A1565 ( 4.5A)
None
None
None
 1.19A 3t7vA-5a4jA:
2.2		 3t7vA-5a4jA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF01399
(PCI)
PF01399
(PCI)
PF05470
(eIF-3c_N) 		5 GLY A 287
GLU C 722
ARG A 340
LEU C 718
ALA C 740
 None
 1.25A 3t7vA-5a5tA:
undetectable		 3t7vA-5a5tA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7s CYSTEINE DESULFURASE

(Thermococcus
onnurineus) 		PF00266
(Aminotran_5) 		5 GLY A 353
GLY A 368
LEU A 393
MET A 390
VAL A 350
 None
 1.22A 3t7vA-5b7sA:
undetectable		 3t7vA-5b7sA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuv ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
cruzi) 		PF00719
(Pyrophosphatase) 		5 THR A  42
GLY A  39
GLU A  60
LEU A  50
ALA A  81
 None
 0.77A 3t7vA-5cuvA:
undetectable		 3t7vA-5cuvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eix DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A

(Klebsiella
pneumoniae) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		5 GLY A1168
TYR A1097
LEU A1131
VAL A1188
ALA A1189
 None
 1.17A 3t7vA-5eixA:
undetectable		 3t7vA-5eixA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		5 GLY A 424
GLY A 384
GLU A 448
GLN A 489
ALA A 486
 EDO  A 601 ( 3.2A)
EDO  A 601 ( 2.8A)
None
None
None
 1.23A 3t7vA-5fifA:
undetectable		 3t7vA-5fifA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		5 THR A  80
GLY A 359
LEU A 336
GLN A 287
VAL A 291
 None
 1.20A 3t7vA-5fx8A:
undetectable		 3t7vA-5fx8A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		5 THR A 305
GLY A  36
ARG A 117
VAL A 301
ALA A 300
 None
 1.08A 3t7vA-5gw7A:
undetectable		 3t7vA-5gw7A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		5 GLY A 307
TYR A 371
LEU A 372
MET A 375
ALA A 386
 None
 1.23A 3t7vA-5h2vA:
undetectable		 3t7vA-5h2vA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES

(Corynebacterium
glutamicum) 		PF00933
(Glyco_hydro_3) 		5 GLY A 272
GLY A 314
LEU A 349
MET A  78
VAL A 181
 None
 1.19A 3t7vA-5iobA:
11.3		 3t7vA-5iobA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itg SORBITOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 GLY A 280
GLU A  86
LEU A  84
MET A  98
ALA A  42
 None
 1.12A 3t7vA-5itgA:
undetectable		 3t7vA-5itgA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens) 		PF02275
(CBAH) 		5 GLY A 149
ARG A   3
LEU A 142
VAL A 112
ALA A 115
 None
 1.13A 3t7vA-5j9rA:
undetectable		 3t7vA-5j9rA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT BETA

(Pyrococcus
furiosus) 		PF10418
(DHODB_Fe-S_bind) 		5 THR S 173
GLY S 111
GLY S 113
VAL S 202
ALA S 203
 None
 1.18A 3t7vA-5jfcS:
undetectable		 3t7vA-5jfcS:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktz VHH 12B

(Camelus
dromedarius) 		PF07686
(V-set) 		5 GLY 7  10
GLY 7   8
GLN 7  13
VAL 7 120
ALA 7  14
 None
 1.26A 3t7vA-5ktz7:
undetectable		 3t7vA-5ktz7:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhs BIFUNCTIONAL PROTEIN
FOLD

(Xanthomonas
albilineans) 		no annotation 5 THR A 268
GLY A  17
MET A 184
VAL A 241
ALA A 220
 None
 1.04A 3t7vA-5nhsA:
undetectable		 3t7vA-5nhsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlt CVAA9A

(Collariella
virescens) 		no annotation 5 THR A  84
GLY A 218
GLN A 167
VAL A 149
ALA A 150
 None
None
CU  A 301 (-4.4A)
None
None
 1.25A 3t7vA-5nltA:
undetectable		 3t7vA-5nltA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nth PUTATIVE
AMINOPEPTIDASE

(Leishmania
major) 		PF00883
(Peptidase_M17) 		5 GLY A 300
GLY A 298
MET A 377
VAL A 267
ALA A 266
 None
 1.10A 3t7vA-5nthA:
undetectable		 3t7vA-5nthA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u64 VHH-28

(Camelus
dromedarius) 		PF07686
(V-set) 		5 GLY B  10
GLY B   8
GLN B  13
VAL B 111
ALA B  14
 None
 1.21A 3t7vA-5u64B:
undetectable		 3t7vA-5u64B:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 GLY A  34
TYR A  42
LEU A  48
GLN A 370
ALA A 373
 None
 1.14A 3t7vA-6aphA:
undetectable		 3t7vA-6aphA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btg FUCULOSE PHOSPHATE
ALDOLASE

(Bacillus
thuringiensis) 		no annotation 5 GLY A 122
ARG A  87
LEU A  93
VAL A 172
ALA A 173
 None
 1.13A 3t7vA-6btgA:
undetectable		 3t7vA-6btgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d2v TERB OXIDOREDUCTASE

(Streptomyces) 		no annotation 5 GLY A  10
GLY A  13
LEU A 211
VAL A 114
ALA A 170
 NDP  A 401 (-3.0A)
NDP  A 401 (-3.0A)
None
NDP  A 401 (-3.9A)
None
 1.12A 3t7vA-6d2vA:
undetectable		 3t7vA-6d2vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 GLY D 105
LEU D 258
GLN D 239
VAL D 237
ALA D 238
 None
 1.09A 3t7vA-6f5dD:
undetectable		 3t7vA-6f5dD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM

(Streptomyces
maritimus) 		no annotation 5 GLY A 414
GLU A 424
ARG A 427
MET A  80
ALA A 385
 None
None
None
FAD  A 600 (-4.9A)
None
 1.14A 3t7vA-6fydA:
undetectable		 3t7vA-6fydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbh HOPQ

(Helicobacter
pylori) 		no annotation 5 THR C 372
GLY C 374
GLY C 376
TYR C 162
LEU C 158
 None
 1.10A 3t7vA-6gbhC:
undetectable		 3t7vA-6gbhC:
undetectable