SIMILAR PATTERNS OF AMINO ACIDS FOR 3T3Z_D_9PLD501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		4 LEU A2501
ALA A 199
THR A 224
LEU A 169
 None
 1.00A 3t3zD-1cj0A:
undetectable		 3t3zD-1cj0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzv GLUCOSE-6-PHOSPHATE
ISOMERASE

(Sus scrofa) 		PF00342
(PGI) 		4 LEU A 321
ALA A  62
THR A  60
LEU A  12
 None
 0.94A 3t3zD-1gzvA:
undetectable		 3t3zD-1gzvA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 187
ALA A  68
THR A 121
LEU A 100
 None
 1.02A 3t3zD-1hr7A:
undetectable		 3t3zD-1hr7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkm PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
subtilis) 		PF00381
(PTS-HPr) 		4 LEU H  74
PHE H   6
THR H  80
LEU H  44
 None
 0.93A 3t3zD-1kkmH:
undetectable		 3t3zD-1kkmH:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kru GALACTOSIDE
O-ACETYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2) 		4 PHE A  55
LEU A  88
PHE A  82
ALA A  62
 None
 1.00A 3t3zD-1kruA:
undetectable		 3t3zD-1kruA:
16.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 PHE A 114
ALA A 294
THR A 298
LEU A 363
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-4.0A)
 0.70A 3t3zD-1nr6A:
50.7		 3t3zD-1nr6A:
57.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 LEU A 209
PHE A 222
ALA A 245
LEU A 238
 None
 1.01A 3t3zD-1oznA:
undetectable		 3t3zD-1oznA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8d GDNF FAMILY RECEPTOR
ALPHA 1

(Rattus
norvegicus) 		PF02351
(GDNF) 		4 LEU A 260
PHE A 332
ALA A 310
LEU A 246
 None
 1.01A 3t3zD-1q8dA:
undetectable		 3t3zD-1q8dA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkv HOMOSERINE KINASE

(Pseudomonas
aeruginosa) 		PF12710
(HAD) 		4 LEU A 196
PHE A  84
ALA A   4
LEU A 191
 None
 0.84A 3t3zD-1rkvA:
undetectable		 3t3zD-1rkvA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sc6 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Escherichia
coli) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		4 LEU A 281
ALA A 238
THR A 290
LEU A 123
 None
 1.00A 3t3zD-1sc6A:
undetectable		 3t3zD-1sc6A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 PHE C 715
LEU C 685
ALA C 720
LEU C 694
 None
 0.99A 3t3zD-1u6gC:
undetectable		 3t3zD-1u6gC:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc8 LYSINE BIOSYNTHESIS
ENZYME

(Thermus
thermophilus) 		PF08443
(RimK) 		4 LEU A  53
ALA A 279
THR A  50
LEU A  25
 None
 0.91A 3t3zD-1uc8A:
undetectable		 3t3zD-1uc8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umg 385AA LONG CONSERVED
HYPOTHETICAL PROTEIN

(Sulfurisphaera
tokodaii) 		PF01950
(FBPase_3) 		4 PHE A 129
LEU A 248
ALA A 254
THR A 153
 None
 0.96A 3t3zD-1umgA:
undetectable		 3t3zD-1umgA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		4 PHE A 285
ALA A 245
THR A 243
LEU A 190
 None
 0.96A 3t3zD-1us4A:
undetectable		 3t3zD-1us4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		4 LEU A 158
PHE A 326
THR A 132
LEU A 178
 None
 0.76A 3t3zD-1vgmA:
undetectable		 3t3zD-1vgmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdj HYPOTHETICAL PROTEIN
TT1808

(Thermus
thermophilus) 		PF05685
(Uma2) 		4 LEU A  52
PHE A 179
ALA A 180
LEU A 183
 None
 0.98A 3t3zD-1wdjA:
undetectable		 3t3zD-1wdjA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		4 LEU A 251
ALA A 337
THR A 340
LEU A 314
 None
 0.90A 3t3zD-1wzzA:
undetectable		 3t3zD-1wzzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypz T-CELL RECEPTOR
GAMMA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE F 157
ALA F 156
THR F 185
LEU F 153
 None
None
NAG  F 231 (-2.7A)
None
 0.98A 3t3zD-1ypzF:
undetectable		 3t3zD-1ypzF:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw1 PROTEIN YTNJ

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		4 LEU A 422
ALA A  43
THR A  87
LEU A  80
 None
 0.99A 3t3zD-1yw1A:
undetectable		 3t3zD-1yw1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Chromobacterium
violaceum) 		PF04952
(AstE_AspA) 		4 LEU A 177
PHE A 211
ALA A 210
LEU A 166
 None
 0.97A 3t3zD-1yw4A:
undetectable		 3t3zD-1yw4A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bba EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		4 PHE A 178
ALA A 177
THR A  75
LEU A 166
 None
 0.79A 3t3zD-2bbaA:
undetectable		 3t3zD-2bbaA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 PHE A 282
LEU A 257
THR A 263
LEU A 244
 None
 0.99A 3t3zD-2ffhA:
undetectable		 3t3zD-2ffhA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6b RAS-RELATED PROTEIN
RAB-26

(Homo sapiens) 		PF00071
(Ras) 		4 LEU A  80
PHE A 218
ALA A 217
LEU A 143
 None
 0.98A 3t3zD-2g6bA:
undetectable		 3t3zD-2g6bA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE

(Trypanosoma
brucei) 		PF00365
(PFK) 		4 LEU A 309
ALA A 290
THR A 451
LEU A 294
 None
 0.97A 3t3zD-2higA:
undetectable		 3t3zD-2higA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Porphyromonas
gingivalis) 		PF00588
(SpoU_methylase) 		4 LEU A 101
ALA A 244
THR A 120
LEU A 202
 None
 0.95A 3t3zD-2i6dA:
undetectable		 3t3zD-2i6dA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jan TYROSYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00579
(tRNA-synt_1b) 		4 LEU A 241
PHE A 257
ALA A 301
THR A 305
 None
 0.85A 3t3zD-2janA:
undetectable		 3t3zD-2janA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrq HYPOTHETICAL PROTEIN
ORF-C20_032

(Sulfolobus
solfataricus) 		PF01877
(RNA_binding) 		4 PHE A  67
LEU A  79
THR A  85
LEU A  97
 None
 0.95A 3t3zD-2nrqA:
undetectable		 3t3zD-2nrqA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6t DNAB REPLICATION
FORK HELICASE

(Thermus
aquaticus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		4 LEU A 190
PHE A 216
ALA A 217
LEU A 197
 None
 0.77A 3t3zD-2q6tA:
undetectable		 3t3zD-2q6tA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r26 CITRATE SYNTHASE

(Thermoplasma
acidophilum) 		PF00285
(Citrate_synt) 		4 LEU A 161
PHE A 329
THR A 135
LEU A 181
 None
 0.99A 3t3zD-2r26A:
undetectable		 3t3zD-2r26A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Plasmodium
vivax) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 LEU A 392
ALA A 279
THR A 146
LEU A 409
 None
DMS  A 999 ( 4.6A)
DMS  A 999 ( 4.8A)
None
 1.00A 3t3zD-2yneA:
undetectable		 3t3zD-2yneA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 492
PHE A 483
THR A 459
LEU A 476
 None
 1.01A 3t3zD-2z63A:
undetectable		 3t3zD-2z63A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 PHE A 292
LEU A 340
ALA A 393
LEU A 322
 None
 0.92A 3t3zD-2zufA:
undetectable		 3t3zD-2zufA:
23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 116
LEU A 210
PHE A 298
ALA A 299
THR A 303
LEU A 368
 None
None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 (-3.6A)
 0.28A 3t3zD-3e4eA:
63.6		 3t3zD-3e4eA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		4 PHE A 209
ALA A 202
THR A 200
LEU A 257
 None
 0.96A 3t3zD-3futA:
undetectable		 3t3zD-3futA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 PHE A 124
LEU A 177
ALA A 163
LEU A 155
 None
 1.00A 3t3zD-3gq9A:
undetectable		 3t3zD-3gq9A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Cytophaga
hutchinsonii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 LEU A 306
ALA A 322
THR A 365
LEU A 390
 None
 0.98A 3t3zD-3ilvA:
undetectable		 3t3zD-3ilvA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		4 PHE A 184
LEU A 236
ALA A 288
LEU A 262
 None
None
HEM  A 488 ( 4.9A)
None
 0.85A 3t3zD-3kswA:
25.7		 3t3zD-3kswA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m19 VARIABLE LYMPHOCYTE
RECEPTOR A DIVERSITY
REGION

(Petromyzon
marinus) 		PF13855
(LRR_8) 		4 LEU A 113
PHE A 126
ALA A 149
LEU A 142
 None
 0.99A 3t3zD-3m19A:
undetectable		 3t3zD-3m19A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1h LYSINE SPECIFIC
CYSTEINE PROTEASE

(Porphyromonas
gingivalis) 		PF07675
(Cleaved_Adhesin) 		4 PHE A1581
ALA A1580
THR A1494
LEU A1572
 None
 0.88A 3t3zD-3m1hA:
undetectable		 3t3zD-3m1hA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 PHE A 362
LEU A 325
ALA A 310
LEU A 335
 None
 0.82A 3t3zD-3ng0A:
undetectable		 3t3zD-3ng0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqn UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		PF12723
(DUF3809) 		4 PHE A 108
LEU A  37
ALA A  30
LEU A  78
 MRD  A 161 ( 4.7A)
None
MRD  A 161 (-3.2A)
MRD  A 161 ( 4.5A)
 0.94A 3t3zD-3nqnA:
undetectable		 3t3zD-3nqnA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		4 PHE A 181
LEU A 417
ALA A 276
LEU A 266
 None
 1.01A 3t3zD-3pt1A:
undetectable		 3t3zD-3pt1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		4 LEU A 427
ALA A  42
THR A  86
LEU A  79
 None
 0.91A 3t3zD-3sdoA:
undetectable		 3t3zD-3sdoA:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 PHE A 115
PHE A 297
ALA A 298
THR A 302
 None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 0.60A 3t3zD-3tk3A:
53.9		 3t3zD-3tk3A:
49.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus sp.
(in: Bacteria)) 		PF00180
(Iso_dh) 		4 PHE A  36
LEU A 310
ALA A  68
LEU A  25
 None
 1.01A 3t3zD-3u1hA:
undetectable		 3t3zD-3u1hA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 PHE A 354
LEU A  49
ALA A 732
LEU A  27
 None
 0.99A 3t3zD-3v9fA:
undetectable		 3t3zD-3v9fA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 LEU A 324
PHE A 148
ALA A 149
LEU A 287
 None
 0.98A 3t3zD-3w6qA:
undetectable		 3t3zD-3w6qA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 PHE A 309
LEU A 355
PHE A 328
ALA A 313
THR A 326
 None
 1.47A 3t3zD-3zzuA:
undetectable		 3t3zD-3zzuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		4 PHE A  68
LEU A  82
ALA A  52
LEU A  76
 None
 0.89A 3t3zD-4c2lA:
undetectable		 3t3zD-4c2lA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		4 PHE A 313
LEU A 324
THR A 282
LEU A 299
 None
 1.01A 3t3zD-4cp6A:
undetectable		 3t3zD-4cp6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di3 TATT (TP0956)

(Treponema
pallidum) 		PF16811
(TAtT) 		4 PHE A 129
LEU A 156
ALA A 182
LEU A 119
 None
 0.97A 3t3zD-4di3A:
undetectable		 3t3zD-4di3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 PHE A  71
LEU A  88
PHE A 141
LEU A  44
 None
 1.01A 3t3zD-4f0xA:
undetectable		 3t3zD-4f0xA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 PHE A1079
LEU A1110
ALA A1123
LEU A1095
 None
 0.87A 3t3zD-4f4cA:
2.2		 3t3zD-4f4cA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 PHE A 110
LEU A 208
PHE A 290
ALA A 291
 VNT  A 502 (-4.4A)
None
VNT  A 502 (-4.4A)
HEM  A 501 ( 3.5A)
 1.00A 3t3zD-4g3jA:
30.9		 3t3zD-4g3jA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 PHE N 326
LEU N 257
ALA N 311
LEU N 299
 None
 1.00A 3t3zD-4heaN:
undetectable		 3t3zD-4heaN:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzc CYSE, SERINE
ACETYLTRANSFERASE

(Brucella
abortus) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 LEU A 192
ALA A 169
THR A 152
LEU A 164
 None
 0.83A 3t3zD-4hzcA:
undetectable		 3t3zD-4hzcA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 PHE A  68
LEU A  43
PHE A 269
LEU A 343
 None
 0.97A 3t3zD-4iglA:
undetectable		 3t3zD-4iglA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itc LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF07675
(Cleaved_Adhesin) 		4 PHE A1132
ALA A1131
THR A1047
LEU A1123
 None
 0.92A 3t3zD-4itcA:
undetectable		 3t3zD-4itcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		4 PHE A 375
LEU A 145
ALA A 259
LEU A 371
 None
 0.93A 3t3zD-4j6cA:
30.3		 3t3zD-4j6cA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		4 LEU A   4
ALA A  65
THR A  10
LEU A  46
 None
 0.97A 3t3zD-4lfeA:
undetectable		 3t3zD-4lfeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n78 CYTOPLASMIC
FMR1-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF05994
(FragX_IP)
PF07159
(DUF1394) 		4 PHE A 600
LEU A 263
ALA A 156
THR A 160
 None
 0.94A 3t3zD-4n78A:
undetectable		 3t3zD-4n78A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		4 LEU A 431
ALA A 511
THR A 509
LEU A 437
 None
 1.01A 3t3zD-4pkvA:
undetectable		 3t3zD-4pkvA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po4 LAMPETRA PLANERI
VLRC

(Lampetra
planeri) 		PF13855
(LRR_8) 		4 LEU A 119
PHE A 132
ALA A 155
LEU A 148
 None
 0.97A 3t3zD-4po4A:
undetectable		 3t3zD-4po4A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		5 PHE A 365
LEU A 421
ALA A 372
THR A 408
LEU A 329
 None
 1.47A 3t3zD-4pspA:
undetectable		 3t3zD-4pspA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgs ALCOHOL
DEHYDROGENASE YQHD

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 PHE A 172
LEU A  54
ALA A  91
THR A  35
 None
 0.97A 3t3zD-4qgsA:
undetectable		 3t3zD-4qgsA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 LEU A 197
ALA A 167
THR A 190
LEU A 178
 None
 0.99A 3t3zD-4u7lA:
undetectable		 3t3zD-4u7lA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		4 PHE A 226
LEU A 216
ALA A 199
LEU A 209
 None
 1.02A 3t3zD-4v2dA:
undetectable		 3t3zD-4v2dA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woy MITOCHONDRIAL
DYNAMICS PROTEIN
MID49

(Mus musculus) 		PF03281
(Mab-21) 		4 LEU A 257
PHE A 173
ALA A 198
LEU A 262
 None
 0.96A 3t3zD-4woyA:
undetectable		 3t3zD-4woyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 LEU A 242
ALA A 192
THR A 165
LEU A 226
 None
 0.99A 3t3zD-4wy5A:
undetectable		 3t3zD-4wy5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)

(Candidatus
Korarchaeum
cryptofilum) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 PHE A 318
LEU A 380
ALA A 376
LEU A 325
 None
 0.88A 3t3zD-4xz3A:
undetectable		 3t3zD-4xz3A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		4 LEU A  11
PHE A  41
ALA A  42
LEU A  53
 None
 0.84A 3t3zD-4yisA:
undetectable		 3t3zD-4yisA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5p CYTOCHROME P450
HYDROXYLASE

(Streptomyces
atroolivaceus) 		PF00067
(p450) 		4 LEU A 372
ALA A 251
THR A 254
LEU A 395
 None
 0.90A 3t3zD-4z5pA:
28.3		 3t3zD-4z5pA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbt ACETOACETATE
DECARBOXYLASE

(Streptomyces
bingchenggensis) 		PF06314
(ADC) 		4 PHE A  33
LEU A 234
ALA A  40
THR A  43
 None
 0.99A 3t3zD-4zbtA:
undetectable		 3t3zD-4zbtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnt ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 4 LEU C 139
ALA C 245
THR C 249
LEU C 279
 None
 0.92A 3t3zD-5bntC:
undetectable		 3t3zD-5bntC:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdo DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B

(Staphylococcus
aureus) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 LEU B 604
ALA B 514
THR B 507
LEU B 521
 None
 0.99A 3t3zD-5cdoB:
undetectable		 3t3zD-5cdoB:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 LEU h 282
ALA h 290
THR h 288
LEU h 244
 None
 1.01A 3t3zD-5gw5h:
undetectable		 3t3zD-5gw5h:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		4 LEU A 179
PHE A 208
ALA A 209
LEU A 200
 None
 0.94A 3t3zD-5gw8A:
undetectable		 3t3zD-5gw8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE

(Methanohalophilus
portucalensis) 		PF13649
(Methyltransf_25) 		4 PHE A 152
LEU A 139
ALA A  67
LEU A 164
 None
None
SAH  A 301 (-3.9A)
None
 0.99A 3t3zD-5h02A:
undetectable		 3t3zD-5h02A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PHE A 427
LEU A 422
ALA A 440
LEU A 450
 None
 0.90A 3t3zD-5ijbA:
undetectable		 3t3zD-5ijbA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 LEU A 578
PHE A 596
ALA A 595
LEU A 562
 None
 1.00A 3t3zD-5l5gA:
undetectable		 3t3zD-5l5gA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nij VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 4 PHE A 214
LEU A 143
ALA A 193
LEU A 200
 None
 0.90A 3t3zD-5nijA:
undetectable		 3t3zD-5nijA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE

(Bacillus
subtilis) 		no annotation 4 PHE A  44
LEU A 120
ALA A  22
LEU A 104
 None
 0.84A 3t3zD-5np9A:
undetectable		 3t3zD-5np9A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nws SAACMM

(Streptomyces
antibioticus) 		no annotation 4 LEU A 406
ALA A 282
THR A 285
LEU A 429
 None
 1.01A 3t3zD-5nwsA:
29.7		 3t3zD-5nwsA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nws SAACMM

(Streptomyces
antibioticus) 		no annotation 4 LEU A 431
ALA A 282
THR A 285
LEU A 426
 None
 1.00A 3t3zD-5nwsA:
29.7		 3t3zD-5nwsA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obt VACUOLAR-PROCESSING
ENZYME GAMMA-ISOZYME

(Arabidopsis
thaliana) 		no annotation 4 PHE A 214
LEU A 143
ALA A 193
LEU A 200
 None
 0.94A 3t3zD-5obtA:
undetectable		 3t3zD-5obtA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2o I-ONUI_E-AG011377

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		4 LEU A  15
PHE A  45
ALA A  46
LEU A  57
 None
 0.96A 3t3zD-5t2oA:
undetectable		 3t3zD-5t2oA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tws HUMAN DNA POLYMERASE
MU

(Homo sapiens) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		4 LEU A 484
PHE A 440
ALA A 494
THR A 147
 None
 0.99A 3t3zD-5twsA:
undetectable		 3t3zD-5twsA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufl PROTEIN CIP2A

(Homo sapiens) 		no annotation 4 LEU A 257
PHE A 226
THR A 216
LEU A 197
 None
 1.02A 3t3zD-5uflA:
undetectable		 3t3zD-5uflA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3

(Homo sapiens) 		no annotation 4 PHE A 439
ALA A 458
THR A 460
LEU A 528
 None
 1.00A 3t3zD-5uvgA:
undetectable		 3t3zD-5uvgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		4 PHE A 738
PHE A 674
ALA A 673
LEU A 358
 None
None
None
EDO  A 820 (-4.2A)
 0.96A 3t3zD-5v1wA:
undetectable		 3t3zD-5v1wA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Escherichia
coli) 		no annotation 4 PHE A  22
LEU A  36
ALA A  60
LEU A  42
 None
 0.98A 3t3zD-5wlyA:
undetectable		 3t3zD-5wlyA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 4 LEU A 334
ALA A 544
THR A 296
LEU A 371
 None
 0.83A 3t3zD-5x9wA:
undetectable		 3t3zD-5x9wA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 4 LEU A 501
ALA A 490
THR A 504
LEU A 473
 None
 1.00A 3t3zD-5xpgA:
undetectable		 3t3zD-5xpgA:
11.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 4 LEU A 208
ALA A 297
THR A 301
LEU A 366
 LSN  A 501 (-3.9A)
LSN  A 501 ( 3.3A)
HEM  A 504 (-4.0A)
HEM  A 504 ( 4.4A)
 0.88A 3t3zD-5xxiA:
50.0		 3t3zD-5xxiA:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 4 LEU A 972
PHE A 924
ALA A 826
THR A 859
 None
 0.95A 3t3zD-5xyaA:
undetectable		 3t3zD-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 4 LEU A 467
PHE A 292
ALA A 293
THR A 297
 EDO  A 503 (-4.2A)
TPF  A 506 ( 4.0A)
TPF  A 506 ( 3.2A)
HEM  A 501 (-3.4A)
 0.84A 3t3zD-6ay4A:
31.4		 3t3zD-6ay4A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM
V-TYPE PROTON ATPASE
SUBUNIT E

(Saccharomyces
cerevisiae) 		no annotation 5 LEU M  46
PHE A 417
ALA A 420
THR A 475
LEU A 539
 None
 1.46A 3t3zD-6c6lM:
undetectable		 3t3zD-6c6lM:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM
V-TYPE PROTON ATPASE
SUBUNIT E

(Saccharomyces
cerevisiae) 		no annotation 5 LEU M  46
PHE A 417
ALA A 420
THR A 475
LEU A 736
 None
 1.38A 3t3zD-6c6lM:
undetectable		 3t3zD-6c6lM:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 4 LEU A 403
PHE A 386
ALA A 387
LEU A 123
 None
 0.77A 3t3zD-6c8zA:
undetectable		 3t3zD-6c8zA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU B 661
PHE B 494
THR B 679
LEU B 612
 None
 1.00A 3t3zD-6f42B:
undetectable		 3t3zD-6f42B:
10.49