SIMILAR PATTERNS OF AMINO ACIDS FOR 3T3Z_C_9PLC501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 PHE A 293
ALA A 289
THR A 349
LEU A 307
 None
 1.17A 3t3zC-1dedA:
undetectable		 3t3zC-1dedA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		4 PHE A  16
ALA A 166
THR A 170
LEU A 150
 None
 1.17A 3t3zC-1dgmA:
0.0		 3t3zC-1dgmA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 PHE A 344
ALA A 284
THR A 286
LEU A 276
 None
 1.06A 3t3zC-1dppA:
0.0		 3t3zC-1dppA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PHE B 431
PHE B 353
ALA B 392
LEU B 328
 None
 1.11A 3t3zC-1ffvB:
undetectable		 3t3zC-1ffvB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 PHE A 439
ALA A 232
THR A 213
LEU A 158
 None
 1.02A 3t3zC-1gzkA:
undetectable		 3t3zC-1gzkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j7h HYPOTHETICAL PROTEIN
HI0719

(Haemophilus
influenzae) 		PF01042
(Ribonuc_L-PSP) 		4 PHE A  96
ALA A 125
THR A  30
LEU A  55
 None
 1.21A 3t3zC-1j7hA:
undetectable		 3t3zC-1j7hA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf5 ALPHA AMYLASE II

(Thermoactinomyces
vulgaris) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 PHE A 192
PHE A 141
ALA A 142
LEU A 225
 None
 1.18A 3t3zC-1jf5A:
undetectable		 3t3zC-1jf5A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 PHE A  21
ALA A 249
THR A 252
LEU A  80
 None
 1.13A 3t3zC-1kl7A:
0.0		 3t3zC-1kl7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 PHE A 757
PHE A 717
THR A 788
LEU A 735
 None
 1.13A 3t3zC-1l5jA:
0.0		 3t3zC-1l5jA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6j MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00040
(fn2)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 PHE A 204
PHE A 403
ALA A 400
LEU A 395
 None
 1.16A 3t3zC-1l6jA:
undetectable		 3t3zC-1l6jA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 PHE A 114
ALA A 294
THR A 298
LEU A 363
 DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
HEM  A 500 (-4.0A)
 0.73A 3t3zC-1nr6A:
50.7		 3t3zC-1nr6A:
57.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p16 MRNA CAPPING ENZYME
ALPHA SUBUNIT

(Candida
albicans) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 PHE A 256
PHE A 341
ALA A 324
LEU A 304
 None
 1.10A 3t3zC-1p16A:
undetectable		 3t3zC-1p16A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 PHE A 651
ALA A 670
THR A 672
LEU A 609
 None
 1.18A 3t3zC-1qhoA:
undetectable		 3t3zC-1qhoA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qib 72 KDA TYPE IV
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 PHE A 180
PHE A 203
ALA A 200
LEU A 195
 None
 1.12A 3t3zC-1qibA:
undetectable		 3t3zC-1qibA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r94 PROTEIN YFHF

(Escherichia
coli) 		PF01521
(Fe-S_biosyn) 		4 PHE A  90
PHE A  88
ALA A   9
LEU A  28
 None
 1.22A 3t3zC-1r94A:
undetectable		 3t3zC-1r94A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rli TRP REPRESSOR
BINDING PROTEIN

(Bacillus
subtilis) 		PF03358
(FMN_red) 		4 PHE A 136
ALA A 119
THR A  16
LEU A  87
 None
None
PT  A 606 (-4.2A)
None
 1.22A 3t3zC-1rliA:
undetectable		 3t3zC-1rliA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		4 PHE A 130
ALA A 143
THR A 148
LEU A 226
 None
 1.14A 3t3zC-1t8hA:
undetectable		 3t3zC-1t8hA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 PHE D  46
ALA D  49
THR D  98
LEU D  70
 None
 1.15A 3t3zC-1u0nD:
undetectable		 3t3zC-1u0nD:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		4 PHE A 285
ALA A 245
THR A 243
LEU A 190
 None
 0.94A 3t3zC-1us4A:
undetectable		 3t3zC-1us4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A  27
ALA B 345
THR A   4
LEU A  23
 None
 1.20A 3t3zC-1wytA:
undetectable		 3t3zC-1wytA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yco BRANCHED-CHAIN
PHOSPHOTRANSACYLASE

(Enterococcus
faecalis) 		PF01515
(PTA_PTB) 		4 PHE A 177
ALA A 137
THR A 117
LEU A 153
 None
 1.22A 3t3zC-1ycoA:
undetectable		 3t3zC-1ycoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypz T-CELL RECEPTOR
GAMMA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE F 157
ALA F 156
THR F 185
LEU F 153
 None
None
NAG  F 231 (-2.7A)
None
 0.93A 3t3zC-1ypzF:
undetectable		 3t3zC-1ypzF:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bba EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		4 PHE A 178
ALA A 177
THR A  75
LEU A 166
 None
 0.80A 3t3zC-2bbaA:
undetectable		 3t3zC-2bbaA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4

(Escherichia
coli) 		PF02113
(Peptidase_S13) 		4 PHE A  82
ALA A 311
THR A  68
LEU A 295
 None
 1.18A 3t3zC-2exaA:
undetectable		 3t3zC-2exaA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsd MATRIX
METALLOPROTEINASE-20

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 PHE A 205
PHE A 228
ALA A 225
LEU A 220
 None
 1.09A 3t3zC-2jsdA:
undetectable		 3t3zC-2jsdA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n3e MAJOR AMPULLATE
SPIDROIN 1

(Latrodectus
hesperus) 		PF16763
(Spidroin_N) 		4 PHE A  70
ALA A  75
THR A  88
LEU A  96
 None
 1.19A 3t3zC-2n3eA:
undetectable		 3t3zC-2n3eA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 PHE A 333
PHE A 372
ALA A 320
LEU A 325
 None
 1.23A 3t3zC-2o0rA:
undetectable		 3t3zC-2o0rA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1q PUTATIVE
ACETYL/PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Methylibium
petroleiphilum) 		no annotation 4 PHE A 116
PHE A 112
THR A 104
LEU A 120
 None
ACT  A 149 ( 4.6A)
ACT  A 149 (-2.6A)
None
 1.20A 3t3zC-2o1qA:
undetectable		 3t3zC-2o1qA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy4 NEUTROPHIL
COLLAGENASE

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 PHE A 176
PHE A 199
ALA A 196
LEU A 191
 None
 1.11A 3t3zC-2oy4A:
undetectable		 3t3zC-2oy4A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3p HYPOTHETICAL PROTEIN

(Porphyromonas
gingivalis) 		PF11644
(DUF3256) 		4 PHE A  73
PHE A 118
THR A 129
LEU A  81
 None
 1.09A 3t3zC-2p3pA:
undetectable		 3t3zC-2p3pA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prr ALKYLHYDROPEROXIDASE
AHPD CORE:
UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF02627
(CMD) 		4 PHE A 129
ALA A 130
THR A 165
LEU A  68
 None
 1.11A 3t3zC-2prrA:
undetectable		 3t3zC-2prrA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 PHE A 264
ALA A 261
THR A  12
LEU A 218
 None
 1.18A 3t3zC-2qvwA:
undetectable		 3t3zC-2qvwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv6 CFXB

(Citrobacter
freundii) 		PF01376
(Enterotoxin_b) 		4 PHE D  42
ALA D  75
THR D  71
LEU D  85
 None
 1.13A 3t3zC-2wv6D:
undetectable		 3t3zC-2wv6D:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Geobacillus
kaustophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 PHE A 288
ALA A 307
THR A 302
LEU A 207
 None
 1.23A 3t3zC-2ys6A:
undetectable		 3t3zC-2ys6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		4 PHE A  74
ALA A 155
THR A 158
LEU A  65
 None
 1.23A 3t3zC-2yzwA:
undetectable		 3t3zC-2yzwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 492
PHE A 483
THR A 459
LEU A 476
 None
 1.04A 3t3zC-2z63A:
undetectable		 3t3zC-2z63A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 PHE A 492
PHE A 483
THR A 459
LEU A 476
 None
 1.10A 3t3zC-2z66A:
undetectable		 3t3zC-2z66A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1

(Homo sapiens) 		PF01380
(SIS) 		4 PHE A 487
ALA A 488
THR A 391
LEU A 370
 None
 1.02A 3t3zC-2zj4A:
undetectable		 3t3zC-2zj4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a76 GAMMA-HEXACHLOROCYCL
OHEXANE
DEHYDROCHLORINASE

(Sphingomonas
paucimobilis) 		PF13577
(SnoaL_4) 		4 PHE A 113
ALA A 131
THR A 133
LEU A  64
 GOL  A 502 (-4.9A)
GOL  A 502 (-3.0A)
SPD  A 300 (-4.0A)
SPD  A 300 ( 4.9A)
 1.05A 3t3zC-3a76A:
undetectable		 3t3zC-3a76A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5e MLL8374 PROTEIN

(Mesorhizobium
japonicum) 		no annotation 4 PHE A 114
PHE A  94
ALA A  95
LEU A 109
 None
 1.23A 3t3zC-3b5eA:
undetectable		 3t3zC-3b5eA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bal ACETYLACETONE-CLEAVI
NG ENZYME

(Acinetobacter
johnsonii) 		no annotation 4 PHE A 119
PHE A 115
THR A 107
LEU A 123
 None
 1.21A 3t3zC-3balA:
undetectable		 3t3zC-3balA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 PHE A 411
PHE A 327
ALA A 322
LEU A 316
 None
 1.12A 3t3zC-3d45A:
undetectable		 3t3zC-3d45A:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 106
PHE A 298
ALA A 299
THR A 303
 None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
 0.98A 3t3zC-3e4eA:
63.5		 3t3zC-3e4eA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 116
PHE A 298
ALA A 299
THR A 303
LEU A 368
 None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 (-3.6A)
 0.28A 3t3zC-3e4eA:
63.5		 3t3zC-3e4eA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efx CHOLERA ENTEROTOXIN
SUBUNIT B,
HEAT-LABILE
ENTEROTOXIN B CHAIN

(Escherichia
coli;
Vibrio cholerae) 		PF01376
(Enterotoxin_b) 		4 PHE D  42
ALA D  75
THR D  71
LEU D  85
 None
 1.09A 3t3zC-3efxD:
undetectable		 3t3zC-3efxD:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 PHE A 710
ALA A 830
THR A 895
LEU A 206
 None
 1.20A 3t3zC-3egwA:
undetectable		 3t3zC-3egwA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fut DIMETHYLADENOSINE
TRANSFERASE

(Thermus
thermophilus) 		PF00398
(RrnaAD) 		4 PHE A 209
ALA A 202
THR A 200
LEU A 257
 None
 1.00A 3t3zC-3futA:
undetectable		 3t3zC-3futA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 492
PHE A 483
THR A 459
LEU A 476
 None
 1.05A 3t3zC-3fxiA:
undetectable		 3t3zC-3fxiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		4 PHE A 284
ALA A 205
THR A 225
LEU A  85
 None
 1.18A 3t3zC-3g8mA:
undetectable		 3t3zC-3g8mA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htk E3 SUMO-PROTEIN
LIGASE MMS21
STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
5

(Saccharomyces
cerevisiae) 		PF11789
(zf-Nse)
no annotation 		4 PHE A 342
ALA B 766
THR C  69
LEU A 345
 None
 1.15A 3t3zC-3htkA:
undetectable		 3t3zC-3htkA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if6 OXA-46 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		4 PHE C  74
PHE C  81
ALA C 137
LEU C 164
 None
 1.14A 3t3zC-3if6C:
undetectable		 3t3zC-3if6C:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PHE A 151
PHE A 387
ALA A 229
LEU A 195
 None
None
None
CSO  A 191 ( 3.5A)
 1.06A 3t3zC-3iv0A:
undetectable		 3t3zC-3iv0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3km3 DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE

(Anaplasma
phagocytophilum) 		no annotation 4 PHE A 155
ALA A  43
THR A  90
LEU A 122
 None
 1.07A 3t3zC-3km3A:
undetectable		 3t3zC-3km3A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		4 PHE A 109
PHE A 289
ALA A 290
THR A 294
 TPF  A 490 (-4.5A)
TPF  A 490 (-4.3A)
TPF  A 490 ( 3.4A)
TPF  A 490 ( 3.5A)
 1.15A 3t3zC-3l4dA:
30.7		 3t3zC-3l4dA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lao ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		4 PHE A  33
PHE A  66
ALA A  61
LEU A  41
 None
 1.00A 3t3zC-3laoA:
undetectable		 3t3zC-3laoA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1h LYSINE SPECIFIC
CYSTEINE PROTEASE

(Porphyromonas
gingivalis) 		PF07675
(Cleaved_Adhesin) 		4 PHE A1581
ALA A1580
THR A1494
LEU A1572
 None
 0.81A 3t3zC-3m1hA:
undetectable		 3t3zC-3m1hA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn2 PROBABLE ARAC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Rhodopseudomonas
palustris) 		PF12833
(HTH_18) 		4 PHE A 256
PHE A 267
ALA A 268
LEU A 241
 None
None
PO4  A   2 (-3.6A)
None
 1.02A 3t3zC-3mn2A:
undetectable		 3t3zC-3mn2A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2x COLLAGENASE 3

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 PHE A1201
PHE A1224
ALA A1221
LEU A1216
 None
 1.15A 3t3zC-3o2xA:
undetectable		 3t3zC-3o2xA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxv NITROREDUCTASE

(Desulfitobacterium
hafniense) 		PF00881
(Nitroreductase) 		4 PHE A 140
ALA A 139
THR A 136
LEU A  57
 None
 1.01A 3t3zC-3pxvA:
undetectable		 3t3zC-3pxvA:
17.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 PHE A 115
PHE A 297
ALA A 298
THR A 302
 None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 0.56A 3t3zC-3tk3A:
54.0		 3t3zC-3tk3A:
49.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes) 		PF01515
(PTA_PTB) 		4 PHE A 192
ALA A 152
THR A 132
LEU A 168
 None
 1.13A 3t3zC-3uf6A:
undetectable		 3t3zC-3uf6A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Danio rerio;
Eptatretus
burgeri) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PHE A 250
ALA A 246
THR A 285
LEU A 299
 None
 1.20A 3t3zC-3v44A:
undetectable		 3t3zC-3v44A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 PHE A  99
PHE A 121
THR A 174
LEU A 101
 None
 0.99A 3t3zC-3v5rA:
0.9		 3t3zC-3v5rA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 PHE A 453
ALA A 450
THR A 446
LEU A 100
 None
 1.21A 3t3zC-3zu0A:
undetectable		 3t3zC-3zu0A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 PHE A 309
PHE A 328
ALA A 313
THR A 326
 None
 1.21A 3t3zC-3zzuA:
undetectable		 3t3zC-3zzuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 PHE A 533
ALA A 480
THR A 474
LEU A 527
 None
 1.07A 3t3zC-4aieA:
undetectable		 3t3zC-4aieA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 PHE A 161
ALA A 281
THR A  44
LEU A 169
 None
None
None
HEM  A1374 ( 3.9A)
 1.21A 3t3zC-4czpA:
undetectable		 3t3zC-4czpA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 PHE A 103
ALA A 306
THR A 144
LEU A 138
 None
 1.17A 3t3zC-4djiA:
undetectable		 3t3zC-4djiA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PHE A 277
ALA A 312
THR A 206
LEU A 315
 None
 1.18A 3t3zC-4e1jA:
undetectable		 3t3zC-4e1jA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emi TODA

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 PHE A 211
ALA A 222
THR A 206
LEU A 147
 None
 1.12A 3t3zC-4emiA:
undetectable		 3t3zC-4emiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE
PROTEIN DBF4 HOMOLOG
A

(Homo sapiens) 		PF00069
(Pkinase)
PF07535
(zf-DBF) 		4 PHE A 124
PHE B 338
ALA A  77
LEU A  89
 None
 1.16A 3t3zC-4f99A:
undetectable		 3t3zC-4f99A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvl COLLAGENASE 3

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 PHE A 201
PHE A 224
ALA A 221
LEU A 216
 None
 1.14A 3t3zC-4fvlA:
undetectable		 3t3zC-4fvlA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		4 PHE A 110
PHE A 290
ALA A 291
THR A 295
 VNT  A 502 (-4.4A)
VNT  A 502 (-4.4A)
HEM  A 501 ( 3.5A)
VNT  A 502 ( 3.2A)
 1.19A 3t3zC-4g3jA:
31.0		 3t3zC-4g3jA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 4 PHE B 256
ALA B 238
THR B 189
LEU B 242
 None
 1.19A 3t3zC-4iglB:
undetectable		 3t3zC-4iglB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itc LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF07675
(Cleaved_Adhesin) 		4 PHE A1132
ALA A1131
THR A1047
LEU A1123
 None
 0.85A 3t3zC-4itcA:
undetectable		 3t3zC-4itcA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l63 ECXB

(Escherichia
coli) 		PF01376
(Enterotoxin_b) 		4 PHE B  42
ALA B  75
THR B  71
LEU B  85
 None
 1.10A 3t3zC-4l63B:
undetectable		 3t3zC-4l63B:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfy ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 PHE A 344
ALA A 319
THR A 277
LEU A 500
 None
 1.17A 3t3zC-4pfyA:
undetectable		 3t3zC-4pfyA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 PHE A2287
PHE A2305
ALA A2304
LEU A2289
 None
 1.21A 3t3zC-4rh7A:
undetectable		 3t3zC-4rh7A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 SLIT AND NTRK-LIKE
PROTEIN 2

(Mus musculus) 		PF13855
(LRR_8) 		4 PHE B 106
ALA B 105
THR B 129
LEU B  98
 None
 1.20A 3t3zC-4y61B:
undetectable		 3t3zC-4y61B:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans) 		PF01580
(FtsK_SpoIIIE) 		4 PHE A1135
PHE A1107
ALA A1139
LEU A1153
 None
 1.10A 3t3zC-5fv0A:
undetectable		 3t3zC-5fv0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 PHE A 431
ALA A 436
THR A 440
LEU A 423
 None
 1.05A 3t3zC-5gppA:
undetectable		 3t3zC-5gppA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy4 RING-OPENING
AMIDOHYDROLASE

(Frankia sp.
Eul1b) 		PF09663
(Amido_AtzD_TrzD) 		4 PHE A 317
ALA A  95
THR A  93
LEU A 264
 None
 1.16A 3t3zC-5hy4A:
undetectable		 3t3zC-5hy4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij6 LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 PHE A  34
PHE A  86
THR A 102
LEU A 150
 None
 1.15A 3t3zC-5ij6A:
undetectable		 3t3zC-5ij6A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PHE A 490
PHE A 481
THR A 457
LEU A 474
 None
 1.20A 3t3zC-5ijbA:
undetectable		 3t3zC-5ijbA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 PHE A 226
ALA A 163
THR A 174
LEU A 229
 None
 1.22A 3t3zC-5jn9A:
undetectable		 3t3zC-5jn9A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 PHE A 457
ALA A 447
THR A 435
LEU A 364
 None
 1.20A 3t3zC-5ngkA:
undetectable		 3t3zC-5ngkA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN
SMALL ENVELOPE
PROTEIN M

(Tick-borne
encephalitis
virus) 		no annotation 4 PHE A 449
ALA D  45
THR D  48
LEU A 460
 None
 1.21A 3t3zC-5o6vA:
undetectable		 3t3zC-5o6vA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 4 PHE A 221
PHE A 143
ALA A 146
LEU A 218
 None
 1.19A 3t3zC-5o7gA:
undetectable		 3t3zC-5o7gA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 PHE A 204
PHE A 403
ALA A 400
LEU A 395
 None
 1.13A 3t3zC-5th6A:
undetectable		 3t3zC-5th6A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utv PAPAIN-LIKE
PROTEINASE

(Rousettus bat
coronavirus
HKU9) 		no annotation 4 PHE A   9
ALA A  55
THR A  44
LEU A  74
 None
 1.19A 3t3zC-5utvA:
undetectable		 3t3zC-5utvA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3

(Homo sapiens) 		no annotation 4 PHE A 439
ALA A 458
THR A 460
LEU A 528
 None
 1.05A 3t3zC-5uvgA:
undetectable		 3t3zC-5uvgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1w GLYCOSIDE HYDROLASE

(Bacillus
halodurans) 		PF03639
(Glyco_hydro_81) 		4 PHE A 738
PHE A 674
ALA A 673
LEU A 358
 None
None
None
EDO  A 820 (-4.2A)
 0.94A 3t3zC-5v1wA:
undetectable		 3t3zC-5v1wA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria) 		PF02668
(TauD) 		4 PHE A 202
ALA A 150
THR A 199
LEU A 193
 None
 1.06A 3t3zC-5vn6A:
undetectable		 3t3zC-5vn6A:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 4 PHE A 108
PHE A 297
ALA A 298
THR A 302
 9ZJ  A 502 (-4.4A)
9ZJ  A 502 ( 4.5A)
9ZJ  A 502 ( 3.5A)
9ZJ  A 502 ( 3.9A)
 1.15A 3t3zC-5wbgA:
54.4		 3t3zC-5wbgA:
56.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 4 PHE A 197
PHE A 188
ALA A 187
LEU A 171
 None
 1.11A 3t3zC-5yemA:
undetectable		 3t3zC-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqw BACTERIAL ACTIN ALFA

(Bacillus
subtilis) 		no annotation 4 PHE A 126
ALA A  91
THR A  14
LEU A 108
 None
 1.09A 3t3zC-6bqwA:
undetectable		 3t3zC-6bqwA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Danio rerio;
Eptatretus
burgeri) 		no annotation 4 PHE A 250
ALA A 246
THR A 285
LEU A 299
 None
 1.21A 3t3zC-6bxaA:
undetectable		 3t3zC-6bxaA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 417
ALA A 420
THR A 475
LEU A 736
 None
 1.15A 3t3zC-6c6lA:
undetectable		 3t3zC-6c6lA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 4 PHE A 113
PHE A 309
ALA A 310
THR A 314
 None
None
HEM  A 600 ( 3.2A)
HEM  A 600 ( 3.7A)
 1.05A 3t3zC-6c93A:
32.8		 3t3zC-6c93A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Sus scrofa) 		no annotation 4 PHE C  38
ALA C  31
THR C  26
LEU C 249
 None
 1.09A 3t3zC-6exvC:
undetectable		 3t3zC-6exvC:
10.87