SIMILAR PATTERNS OF AMINO ACIDS FOR 3T3S_F_9PLF1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		4 ALA A 244
PHE A 232
ALA A 301
THR A 306
 None
 0.96A 3t3sF-1ezwA:
0.0		 3t3sF-1ezwA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		4 PHE A  22
ALA A 318
PHE A   8
ALA A 313
 None
 0.94A 3t3sF-1f26A:
29.6		 3t3sF-1f26A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		4 ALA A  62
PHE A 193
PHE A 223
ALA A 177
 None
 0.90A 3t3sF-1fbnA:
0.0		 3t3sF-1fbnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g71 DNA PRIMASE

(Pyrococcus
furiosus) 		PF01896
(DNA_primase_S) 		5 PHE A 196
PHE A 206
PHE A 268
ALA A 269
THR A 272
 None
 1.48A 3t3sF-1g71A:
0.0		 3t3sF-1g71A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 PHE A 414
PHE A 463
PHE A 362
ALA A 366
 None
 1.01A 3t3sF-1gpeA:
0.0		 3t3sF-1gpeA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdw CALPAIN II,
CATALYTIC SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 PHE A  87
PHE A 131
PHE A 141
ALA A 179
 None
 0.91A 3t3sF-1mdwA:
0.0		 3t3sF-1mdwA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd5 CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		4 PHE A 156
PHE A 153
ALA A 147
THR A  93
 None
 0.89A 3t3sF-1pd5A:
undetectable		 3t3sF-1pd5A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		4 ALA X 329
ASN X 301
ALA X 303
THR X 237
 None
 0.95A 3t3sF-1pp1X:
0.0		 3t3sF-1pp1X:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP3)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 PHE 3 209
ASN 3 106
ALA 3 203
THR 3  89
 None
 0.96A 3t3sF-1qgc3:
undetectable		 3t3sF-1qgc3:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qv9 F420-DEPENDENT
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE

(Methanopyrus
kandleri) 		PF01993
(MTD) 		4 PHE A   8
PHE A 161
PHE A  67
ALA A  94
 None
 0.90A 3t3sF-1qv9A:
undetectable		 3t3sF-1qv9A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		4 PHE A  87
PHE A 131
PHE A 141
ALA A 179
 None
 1.00A 3t3sF-1qxpA:
undetectable		 3t3sF-1qxpA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		4 ALA A  89
ASN A 107
ALA A 164
THR A 168
 NAD  A 360 (-3.3A)
None
None
None
 0.91A 3t3sF-1rkxA:
undetectable		 3t3sF-1rkxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su3 INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 PHE A 430
ALA A 428
PHE A 464
ALA A 460
 None
CL  A 909 ( 4.0A)
None
None
 0.97A 3t3sF-1su3A:
undetectable		 3t3sF-1su3A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		4 ALA A  67
PHE A 107
ALA A 108
THR A 111
 None
NH4  A 404 (-3.9A)
None
None
 0.95A 3t3sF-1u7gA:
0.8		 3t3sF-1u7gA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v33 DNA PRIMASE SMALL
SUBUNIT

(Pyrococcus
horikoshii) 		PF01896
(DNA_primase_S) 		5 PHE A 196
PHE A 206
PHE A 268
ALA A 269
THR A 272
 None
 1.46A 3t3sF-1v33A:
undetectable		 3t3sF-1v33A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 ALA A 432
PHE A 164
ASN A  76
ALA A  80
 NAD  A 601 (-3.5A)
None
NAD  A 601 ( 2.9A)
None
 0.84A 3t3sF-1vkoA:
undetectable		 3t3sF-1vkoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 PHE A 210
ASN A 287
PHE A 290
ALA A 291
 None
None
None
ZN  A 800 ( 4.3A)
 0.99A 3t3sF-1z1wA:
undetectable		 3t3sF-1z1wA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcm CALPAIN 1, LARGE
[CATALYTIC] SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2) 		4 PHE A  97
PHE A 141
PHE A 151
ALA A 189
 None
 0.95A 3t3sF-1zcmA:
undetectable		 3t3sF-1zcmA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 PHE A1194
PHE A1211
ALA A1173
PHE A1234
 None
 0.94A 3t3sF-2bruA:
undetectable		 3t3sF-2bruA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cas CANINE PARVOVIRUS
EMPTY CAPSID (STRAIN
D) VIRAL PROTEIN 2

(Carnivore
protoparvovirus
1) 		PF00740
(Parvo_coat) 		4 ALA A 486
ASN A 485
ALA A 189
THR A 194
 None
 0.81A 3t3sF-2casA:
undetectable		 3t3sF-2casA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 280
PHE A  14
ALA A  15
THR A  19
 None
 0.99A 3t3sF-2cduA:
undetectable		 3t3sF-2cduA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1p HYPOTHETICAL UPF0116
PROTEIN YHEM

(Escherichia
coli) 		PF02635
(DrsE) 		4 PHE B 119
PHE B   8
PHE B   6
ALA B   5
 None
 0.94A 3t3sF-2d1pB:
undetectable		 3t3sF-2d1pB:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN

(Lepidium
virginicum) 		PF00197
(Kunitz_legume) 		4 ASN A  80
PHE A 122
ALA A  82
THR A  97
 None
 0.82A 3t3sF-2dreA:
undetectable		 3t3sF-2dreA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmd LECTIN

(Leucomphalos
mildbraedii) 		PF00139
(Lectin_legB) 		4 PHE A 128
ALA A 214
ASN A 223
PHE A  75
 None
 0.91A 3t3sF-2fmdA:
undetectable		 3t3sF-2fmdA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Clostridium
acetobutylicum) 		PF02127
(Peptidase_M18) 		4 PHE A  88
ALA A  78
ASN A 312
PHE A 309
 None
 1.00A 3t3sF-2gljA:
undetectable		 3t3sF-2gljA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm8 TENA HOMOLOG/THI-4
THIAMINASE

(Pyrobaculum
aerophilum) 		PF03070
(TENA_THI-4) 		5 PHE A 124
ALA A  57
PHE A 135
ALA A  74
THR A  77
 None
None
HMH  A 301 ( 4.9A)
None
None
 1.22A 3t3sF-2gm8A:
undetectable		 3t3sF-2gm8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxr HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYNR

(Escherichia
coli) 		PF03466
(LysR_substrate) 		4 ALA A 243
PHE A 147
PHE A 101
THR A 200
 None
 0.97A 3t3sF-2hxrA:
undetectable		 3t3sF-2hxrA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i8b MINOR NUCLEOPROTEIN
VP30

(Zaire
ebolavirus) 		PF11507
(Transcript_VP30) 		4 PHE A 242
ALA A 155
PHE A 181
ASN A 244
 None
 0.89A 3t3sF-2i8bA:
undetectable		 3t3sF-2i8bA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqi CALPAIN-1 CATALYTIC
SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 PHE A  97
PHE A 141
PHE A 151
ALA A 189
 None
 0.94A 3t3sF-2nqiA:
undetectable		 3t3sF-2nqiA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nul PEPTIDYLPROLYL
ISOMERASE

(Escherichia
coli) 		PF00160
(Pro_isomerase) 		4 PHE A  98
PHE A  27
ALA A 124
PHE A  41
 None
 0.98A 3t3sF-2nulA:
undetectable		 3t3sF-2nulA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oez UPF0289 PROTEIN
VP2528

(Vibrio
parahaemolyticus) 		PF07072
(ZapD) 		4 PHE A  33
ALA A  30
PHE A 124
ALA A  45
 None
 0.96A 3t3sF-2oezA:
undetectable		 3t3sF-2oezA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0r CALPAIN-9

(Homo sapiens) 		PF00648
(Peptidase_C2) 		4 PHE A  79
PHE A 123
PHE A 133
ALA A 171
 None
 0.93A 3t3sF-2p0rA:
undetectable		 3t3sF-2p0rA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfx UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Ruegeria sp.
TM1040) 		PF02627
(CMD) 		4 PHE A 166
PHE A  53
ASN A 171
ALA A 174
 None
 0.94A 3t3sF-2pfxA:
undetectable		 3t3sF-2pfxA:
17.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 107
PHE A 111
PHE A 209
THR A 305
 None
None
None
HEM  A 500 (-3.6A)
 0.67A 3t3sF-2pg6A:
58.7		 3t3sF-2pg6A:
94.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv4 UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF11269
(DUF3069) 		5 PHE A  72
PHE A  75
ALA A  78
ASN A  79
ALA A 117
 None
 1.40A 3t3sF-2pv4A:
undetectable		 3t3sF-2pv4A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Thermus
thermophilus) 		PF01128
(IspD) 		4 PHE A  63
ALA A  53
ALA A  22
THR A  30
 None
 1.00A 3t3sF-2px7A:
undetectable		 3t3sF-2px7A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 PHE A  13
PHE A  15
PHE A  28
ALA A  58
 PHE  A  13 ( 1.3A)
PHE  A  15 ( 1.3A)
PHE  A  28 ( 1.3A)
ALA  A  58 ( 0.0A)
 0.95A 3t3sF-2qv2A:
undetectable		 3t3sF-2qv2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE

(Porphyromonas
gingivalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 PHE A 238
ALA A 291
PHE A 199
THR A 282
 None
None
None
SO4  A 317 (-3.4A)
 0.91A 3t3sF-2qytA:
undetectable		 3t3sF-2qytA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1p
AQUAPORIN PIP2-7 7

(Komagataella
pastoris) 		PF00230
(MIP) 		4 PHE A  92
PHE A  63
ASN A 112
ALA A 226
 None
 1.00A 3t3sF-2w1pA:
undetectable		 3t3sF-2w1pA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum) 		no annotation 4 PHE A 105
PHE A 106
PHE A 246
ALA A  74
 None
 0.93A 3t3sF-2w3yA:
undetectable		 3t3sF-2w3yA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 350
ASN A  44
PHE A  45
ALA A  48
THR A  39
 None
PO4  A1377 (-4.1A)
None
None
None
 1.33A 3t3sF-2wekA:
undetectable		 3t3sF-2wekA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whk MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus
subtilis) 		PF02156
(Glyco_hydro_26) 		4 PHE A 276
PHE A 295
PHE A 281
THR A 319
 None
 0.98A 3t3sF-2whkA:
undetectable		 3t3sF-2whkA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x32 CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF04264
(YceI) 		5 PHE A  66
PHE A  14
ASN A  48
PHE A  28
THR A  52
 None
OTP  A1174 ( 4.2A)
None
OTP  A1174 ( 4.7A)
None
 1.26A 3t3sF-2x32A:
undetectable		 3t3sF-2x32A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 PHE A 413
PHE A 418
PHE A 294
ALA A 300
 None
 0.95A 3t3sF-2xswA:
undetectable		 3t3sF-2xswA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 PHE A 297
ASN A 375
PHE A 360
ALA A 379
 None
None
None
ZN  A1946 ( 4.2A)
 0.86A 3t3sF-2yd0A:
undetectable		 3t3sF-2yd0A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		4 PHE A 402
ALA A 429
PHE A 420
THR A 472
 None
 0.96A 3t3sF-2yn9A:
0.9		 3t3sF-2yn9A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		4 ALA A 143
PHE A 185
ALA A 186
THR A 190
 None
 0.86A 3t3sF-2zzrA:
undetectable		 3t3sF-2zzrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE

(Pseudomonas
aeruginosa) 		PF14515
(HOASN)
PF14518
(Haem_oxygenas_2) 		4 PHE A 108
ALA A  97
ASN A 300
PHE A 298
 None
 1.00A 3t3sF-3bjdA:
1.3		 3t3sF-3bjdA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 PHE A 403
PHE A 478
ALA A 547
ALA A 553
 None
 0.98A 3t3sF-3dwkA:
undetectable		 3t3sF-3dwkA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3a POSSIBLE PEROXIDASE
BPOC

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 PHE A  36
ALA A  39
PHE A 257
ALA A 258
 None
 0.98A 3t3sF-3e3aA:
undetectable		 3t3sF-3e3aA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 PHE A 237
ALA A 352
PHE A 209
PHE A 406
 None
 1.01A 3t3sF-3e60A:
undetectable		 3t3sF-3e60A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebj POLYMERASE ACIDIC
PROTEIN

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 PHE A   4
PHE A   9
ASN A  33
ALA A  37
 None
 0.79A 3t3sF-3ebjA:
undetectable		 3t3sF-3ebjA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec1 YQEH GTPASE

(Geobacillus
stearothermophilus) 		PF01926
(MMR_HSR1) 		4 ALA A  96
PHE A 198
ASN A  99
THR A 219
 None
 0.94A 3t3sF-3ec1A:
undetectable		 3t3sF-3ec1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3z TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Neisseria
meningitidis) 		PF01047
(MarR) 		4 PHE A  18
PHE A  32
ALA A  33
THR A  37
 None
 1.00A 3t3sF-3g3zA:
undetectable		 3t3sF-3g3zA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gff IROE-LIKE SERINE
HYDROLASE

(Shewanella
oneidensis) 		PF00756
(Esterase) 		4 ASN A 219
PHE A 222
ALA A 223
THR A 227
 None
 0.94A 3t3sF-3gffA:
undetectable		 3t3sF-3gffA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izq ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF08938
(HBS1_N) 		4 PHE 1 170
ALA 1 384
PHE 1 240
ALA 1 245
 None
 0.96A 3t3sF-3izq1:
undetectable		 3t3sF-3izq1:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 ASN A 561
PHE A 564
ALA A 524
THR A 527
 THH  A 642 ( 3.3A)
None
None
None
 0.99A 3t3sF-3k13A:
undetectable		 3t3sF-3k13A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khd PYRUVATE KINASE

(Plasmodium
falciparum) 		PF00224
(PK)
PF02887
(PK_C) 		4 PHE A  77
PHE A  91
PHE A 225
ALA A 226
 None
 0.88A 3t3sF-3khdA:
undetectable		 3t3sF-3khdA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwl UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 ALA A 404
PHE A 466
ASN A 402
THR A 464
 None
 0.91A 3t3sF-3kwlA:
undetectable		 3t3sF-3kwlA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP

(Vibrio cholerae) 		PF01554
(MatE) 		4 PHE A 290
ALA A 372
ALA A 333
THR A 336
 None
 0.99A 3t3sF-3mktA:
undetectable		 3t3sF-3mktA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 PHE A 325
PHE A 134
ALA A 155
THR A 141
 None
 0.97A 3t3sF-3nixA:
undetectable		 3t3sF-3nixA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 PHE A  45
ASN A 270
PHE A 269
THR A 252
 None
 1.00A 3t3sF-3oosA:
undetectable		 3t3sF-3oosA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		5 PHE A 170
ALA A 384
PHE A 240
ALA A 245
THR A 242
 None
 0.95A 3t3sF-3p27A:
undetectable		 3t3sF-3p27A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfo PUTATIVE
ACETYLORNITHINE
DEACETYLASE

(Rhodopseudomonas
palustris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PHE A  30
PHE A  55
ALA A  52
THR A  64
 EDO  A 504 (-4.8A)
None
None
None
 0.99A 3t3sF-3pfoA:
undetectable		 3t3sF-3pfoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		4 PHE A 295
ALA A 292
PHE A 133
THR A  89
 None
 1.01A 3t3sF-3ppoA:
undetectable		 3t3sF-3ppoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbt INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		no annotation 4 PHE B 572
PHE B 574
PHE B 587
ALA B 617
 None
 0.90A 3t3sF-3qbtB:
undetectable		 3t3sF-3qbtB:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryl PROTEIN VPA1370

(Vibrio
parahaemolyticus) 		no annotation 4 PHE A 406
ALA A 273
PHE A 457
PHE A 448
 None
 0.88A 3t3sF-3rylA:
undetectable		 3t3sF-3rylA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s98 INTERFERON
ALPHA/BETA RECEPTOR
1

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 PHE A 266
PHE A 297
ASN A 269
PHE A 271
 None
 0.87A 3t3sF-3s98A:
undetectable		 3t3sF-3s98A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz6 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF05031
(NEAT) 		5 PHE A 144
PHE A  42
ALA A  63
PHE A  87
PHE A  59
 None
 1.43A 3t3sF-3sz6A:
undetectable		 3t3sF-3sz6A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ALA A 573
PHE A 254
PHE A  78
ALA A  72
 None
 0.97A 3t3sF-3szeA:
undetectable		 3t3sF-3szeA:
18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		4 PHE A 108
PHE A 297
ALA A 298
THR A 302
 None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 0.97A 3t3sF-3tk3A:
53.7		 3t3sF-3tk3A:
56.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		4 ALA B 111
PHE B  60
PHE B  37
ALA B  34
 None
 0.92A 3t3sF-3wcuB:
undetectable		 3t3sF-3wcuB:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE

(Parageobacillus
thermoglucosidasius) 		PF00465
(Fe-ADH) 		4 ALA A 848
ASN A 673
ALA A 675
THR A 679
 CSO  A 845 ( 3.9A)
None
None
None
 0.94A 3t3sF-3zdrA:
undetectable		 3t3sF-3zdrA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		4 PHE A 816
PHE A 815
PHE A 792
PHE A 605
 None
 0.81A 3t3sF-3zgbA:
undetectable		 3t3sF-3zgbA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akk NITRATE REGULATORY
PROTEIN

(Klebsiella
oxytoca) 		PF03861
(ANTAR)
PF08376
(NIT) 		4 PHE A 256
ALA A 184
ALA A 125
THR A 129
 None
 0.99A 3t3sF-4akkA:
0.0		 3t3sF-4akkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auo INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 PHE A 411
ALA A 409
PHE A 445
ALA A 441
 None
 1.00A 3t3sF-4auoA:
undetectable		 3t3sF-4auoA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awm POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 PHE A   4
PHE A   9
ASN A  33
ALA A  37
 None
None
None
KDH  A 911 (-3.3A)
 0.96A 3t3sF-4awmA:
undetectable		 3t3sF-4awmA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayr MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Caulobacter sp.
K31) 		PF01532
(Glyco_hydro_47) 		4 ALA A 277
PHE A 237
PHE A 297
ALA A 242
 None
 0.97A 3t3sF-4ayrA:
undetectable		 3t3sF-4ayrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgu MALATE DEHYDROGENASE

(Haloferax
volcanii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ALA A 231
ASN A  20
ALA A  22
THR A  59
 None
CL  A1326 (-3.0A)
None
None
 0.96A 3t3sF-4bguA:
undetectable		 3t3sF-4bguA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e72 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF11738
(DUF3298) 		4 PHE A 167
ALA A 174
ALA A 208
THR A 205
 None
 0.85A 3t3sF-4e72A:
undetectable		 3t3sF-4e72A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gom DNA ADENINE
METHYLASE

(Escherichia
coli) 		PF02086
(MethyltransfD12) 		4 PHE D 160
PHE D  42
PHE D 151
ALA D 152
 None
 0.98A 3t3sF-4gomD:
undetectable		 3t3sF-4gomD:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7n ALDEHYDE
DEHYDROGENASE

(Trichormus
variabilis) 		PF00171
(Aldedh) 		4 PHE A 394
ALA A 236
ALA A 419
THR A 421
 None
 0.96A 3t3sF-4h7nA:
undetectable		 3t3sF-4h7nA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jed GLUTATHIONE
S-TRANSFERASE

(Methylobacterium
radiotolerans) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 PHE A 157
ALA A  95
PHE A 200
ALA A 163
THR A 166
 None
 1.35A 3t3sF-4jedA:
1.7		 3t3sF-4jedA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq6 PROTEORHODOPSIN

(uncultured
bacterium) 		PF01036
(Bac_rhodopsin) 		4 PHE A  15
ALA A  18
ASN A 206
THR A  83
 None
None
None
RET  A 301 (-4.3A)
 0.96A 3t3sF-4jq6A:
undetectable		 3t3sF-4jq6A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrf PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
ovatus) 		PF15495
(Fimbrillin_C) 		4 PHE A 277
ASN A 283
PHE A 282
THR A 487
 None
None
None
PG4  A 614 (-3.6A)
 0.89A 3t3sF-4jrfA:
undetectable		 3t3sF-4jrfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 PHE A 337
ASN A 415
PHE A 400
ALA A 419
 None
None
None
ZN  A1001 ( 4.2A)
 0.98A 3t3sF-4kxbA:
undetectable		 3t3sF-4kxbA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3u UNCHARACTERIZED
PROTEIN

(Acinetobacter
baumannii) 		PF16133
(DUF4844) 		4 PHE A  50
PHE A 126
ASN A  70
ALA A  74
 None
 0.73A 3t3sF-4l3uA:
undetectable		 3t3sF-4l3uA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5o POLYMERASE PA

(Influenza A
virus) 		PF00603
(Flu_PA) 		4 PHE A   4
PHE A   9
ASN A  33
ALA A  37
 None
None
SO4  A 304 (-3.7A)
X48  A 306 ( 3.7A)
 0.83A 3t3sF-4m5oA:
undetectable		 3t3sF-4m5oA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mck CHITINASE

(Zea mays) 		PF00182
(Glyco_hydro_19) 		4 PHE A  39
PHE A   6
PHE A  56
ALA A  57
 None
 0.94A 3t3sF-4mckA:
undetectable		 3t3sF-4mckA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqf NUCLEOTIDYLTRANSFERA
SE

(Agrobacterium
fabrum) 		PF05168
(HEPN) 		4 PHE A 192
ALA A 178
ALA A 197
THR A 200
 None
 0.89A 3t3sF-4nqfA:
undetectable		 3t3sF-4nqfA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntd THIOREDOXIN
REDUCTASE

(Streptomyces
clavuligerus) 		PF07992
(Pyr_redox_2) 		4 ALA A  30
ASN A 298
PHE A 295
ALA A 294
 None
 0.94A 3t3sF-4ntdA:
undetectable		 3t3sF-4ntdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ps6 INHIBITOR OF
VERTEBRATE LYSOZYME

(Pseudomonas
aeruginosa) 		PF08816
(Ivy) 		4 PHE A  97
ALA A  80
PHE A  47
ALA A  60
 None
 0.88A 3t3sF-4ps6A:
undetectable		 3t3sF-4ps6A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqm URACIL-DNA
GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		4 PHE A  35
ALA A  37
PHE A  64
PHE A 163
 None
 0.95A 3t3sF-4uqmA:
undetectable		 3t3sF-4uqmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wik SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH

(Homo sapiens) 		PF00076
(RRM_1)
PF08075
(NOPS) 		4 PHE A 394
PHE A 418
PHE A 436
PHE A 391
 None
 0.95A 3t3sF-4wikA:
undetectable		 3t3sF-4wikA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wva UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		PF01204
(Trehalase) 		5 ALA A 239
PHE A 283
PHE A 303
ALA A 301
THR A 299
 None
 1.42A 3t3sF-4wvaA:
undetectable		 3t3sF-4wvaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 ALA A 265
PHE A  38
PHE A 244
ALA A 241
 IOD  A 307 ( 4.6A)
None
None
None
 0.91A 3t3sF-4xf7A:
undetectable		 3t3sF-4xf7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		4 PHE A 477
ALA A 481
PHE A 505
ALA A 506
 None
 0.86A 3t3sF-4xprA:
undetectable		 3t3sF-4xprA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yip SUPEROXIDE DISMUTASE
[MN/FE]

(Streptococcus
mutans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 PHE A 109
PHE A 184
PHE A 112
ALA A 114
THR A 117
 None
 1.43A 3t3sF-4yipA:
undetectable		 3t3sF-4yipA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yip SUPEROXIDE DISMUTASE
[MN/FE]

(Streptococcus
mutans) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 PHE A 109
PHE A 184
PHE A 112
ALA A 115
THR A 117
 None
 1.29A 3t3sF-4yipA:
undetectable		 3t3sF-4yipA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens;
Mus musculus) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 PHE A 261
ALA A 298
ASN A 302
ALA A 124
 None
 0.67A 3t3sF-4zwjA:
1.3		 3t3sF-4zwjA:
19.14