SIMILAR PATTERNS OF AMINO ACIDS FOR 3T3S_D_9PLD1_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aur | CARBOXYLESTERASE (Pseudomonasfluorescens) |
PF02230(Abhydrolase_2) | 4 | PHE A 125ALA A 142PHE A 145ALA A 137 | None | 0.92A | 3t3sD-1aurA:undetectable | 3t3sD-1aurA:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ek2 | EPOXIDE HYDROLASE (Mus musculus) |
PF00561(Abhydrolase_1)PF13419(HAD_2) | 4 | ALA A 108PHE A 221PHE A 117ALA A 6 | None | 0.85A | 3t3sD-1ek2A:undetectable | 3t3sD-1ek2A:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hp1 | 5'-NUCLEOTIDASE (Escherichiacoli) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 4 | ALA A 464ASN A 465ALA A 399THR A 397 | None | 0.90A | 3t3sD-1hp1A:undetectable | 3t3sD-1hp1A:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3n | 3-OXOACYL-(ACYL-CARRIER PROTEIN)SYNTHASE II (Thermusthermophilus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 4 | PHE A 258ALA A 280ALA A 162THR A 159 | None | 0.93A | 3t3sD-1j3nA:undetectable | 3t3sD-1j3nA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfi | PHOSPHOGLUCOMUTASE 1 (Parameciumtetraurelia) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 4 | PHE A 250ALA A 305PHE A 235ALA A 410 | None | 0.86A | 3t3sD-1kfiA:undetectable | 3t3sD-1kfiA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mty | METHANEMONOOXYGENASEHYDROXYLASE (Methylococcuscapsulatus) |
PF02332(Phenol_Hydrox) | 5 | PHE B 335ALA B 227PHE B 256ASN B 155ALA B 151 | None | 1.38A | 3t3sD-1mtyB:undetectable | 3t3sD-1mtyB:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n2m | PYRUVOYL-DEPENDENTARGININEDECARBOXYLASE (Methanocaldococcusjannaschii) |
PF01862(PvlArgDC) | 4 | PHE A 34ALA A 41ALA A 159THR A 75 | MRD A7006 ( 3.9A)NoneNoneNone | 0.94A | 3t3sD-1n2mA:undetectable | 3t3sD-1n2mA:15.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nr6 | CYTOCHROME P450 2C5 (Oryctolaguscuniculus) |
PF00067(p450) | 4 | ALA A 113PHE A 114ALA A 294THR A 298 | DIF A 501 (-3.6A)DIF A 501 (-4.5A)DIF A 501 ( 3.3A)HEM A 500 ( 3.6A) | 0.78A | 3t3sD-1nr6A:49.4 | 3t3sD-1nr6A:54.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o7x | CITRATE SYNTHASE (Sulfolobussolfataricus) |
PF00285(Citrate_synt) | 5 | PHE A 325PHE A 320ALA A 172PHE A 156ALA A 153 | None | 1.36A | 3t3sD-1o7xA:0.4 | 3t3sD-1o7xA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pp1 | P40 NUCLEOPROTEIN (Borna diseasevirus) |
PF06407(BDV_P40) | 5 | ALA X 329ASN X 301PHE X 299ALA X 303THR X 237 | None | 1.04A | 3t3sD-1pp1X:undetectable | 3t3sD-1pp1X:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pv9 | XAA-PRO DIPEPTIDASE (Pyrococcusfuriosus) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 4 | ALA A 177PHE A 178ALA A 140THR A 341 | None ZN A 402 ( 4.8A)NoneNone | 0.90A | 3t3sD-1pv9A:undetectable | 3t3sD-1pv9A:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qjm | LACTOFERRIN (Equus caballus) |
PF00405(Transferrin) | 4 | PHE A 487ALA A 492PHE A 542ALA A 466 | NoneNoneNoneCO3 A 693 (-4.0A) | 0.94A | 3t3sD-1qjmA:undetectable | 3t3sD-1qjmA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rkx | CDP-GLUCOSE-4,6-DEHYDRATASE (Yersiniapseudotuberculosis) |
PF16363(GDP_Man_Dehyd) | 4 | ALA A 89ASN A 107ALA A 164THR A 168 | NAD A 360 (-3.3A)NoneNoneNone | 0.88A | 3t3sD-1rkxA:undetectable | 3t3sD-1rkxA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7g | PROBABLE AMMONIUMTRANSPORTER (Escherichiacoli) |
PF00909(Ammonium_transp) | 4 | ALA A 67PHE A 107ALA A 108THR A 111 | NoneNH4 A 404 (-3.9A)NoneNone | 0.79A | 3t3sD-1u7gA:undetectable | 3t3sD-1u7gA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u9z | RIBOSE-PHOSPHATEPYROPHOSPHOKINASE (Methanocaldococcusjannaschii) |
PF00156(Pribosyltran)PF13793(Pribosyltran_N) | 4 | ALA A 62ASN A 54ALA A 85THR A 121 | None | 0.94A | 3t3sD-1u9zA:undetectable | 3t3sD-1u9zA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhn | PUTATIVE FLAVINOXIDOREDUCTASE (Thermotogamaritima) |
PF01207(Dus) | 4 | ALA A 24PHE A 223PHE A 31ALA A 32 | None | 0.89A | 3t3sD-1vhnA:undetectable | 3t3sD-1vhnA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w1k | VANILLYL-ALCOHOLOXIDASE (Penicilliumsimplicissimum) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 4 | PHE A 353ALA A 374PHE A 375ALA A 304 | None | 0.87A | 3t3sD-1w1kA:undetectable | 3t3sD-1w1kA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wkm | METHIONINEAMINOPEPTIDASE (Pyrococcusfuriosus) |
PF00557(Peptidase_M24) | 4 | ALA A 49PHE A 50ALA A 13THR A 294 | NoneMET A1298 (-3.8A)NoneNone | 0.83A | 3t3sD-1wkmA:undetectable | 3t3sD-1wkmA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wy2 | XAA-PRO DIPEPTIDASE (Pyrococcushorikoshii) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 4 | ALA A 180PHE A 181ALA A 143THR A 344 | NoneCAC A 403 (-3.7A)NoneNone | 0.91A | 3t3sD-1wy2A:undetectable | 3t3sD-1wy2A:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xwd | FOLLICLE STIMULATINGHORMONE RECEPTOR (Homo sapiens) |
PF01462(LRRNT)PF13306(LRR_5) | 4 | PHE C 91ALA C 65PHE C 66THR C 56 | None | 0.69A | 3t3sD-1xwdC:undetectable | 3t3sD-1xwdC:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b2i | AMMONIUM TRANSPORTER (Archaeoglobusfulgidus) |
PF00909(Ammonium_transp) | 5 | PHE A 89PHE A 63PHE A 96ALA A 97THR A 100 | None | 1.37A | 3t3sD-2b2iA:undetectable | 3t3sD-2b2iA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c8s | CYTOCHROME C-L (Methylobacteriumextorquens) |
PF13442(Cytochrome_CBB3) | 4 | PHE A 98ASN A 45ALA A 35THR A 33 | None | 0.92A | 3t3sD-2c8sA:undetectable | 3t3sD-2c8sA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cas | CANINE PARVOVIRUSEMPTY CAPSID (STRAIND) VIRAL PROTEIN 2 (Carnivoreprotoparvovirus1) |
PF00740(Parvo_coat) | 4 | ALA A 486ASN A 485ALA A 189THR A 194 | None | 0.69A | 3t3sD-2casA:undetectable | 3t3sD-2casA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cdu | NADPH OXIDASE (Lactobacillussanfranciscensis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | ALA A 11PHE A 278ALA A 279THR A 266 | FAD A 500 (-3.5A)NoneNoneNone | 0.87A | 3t3sD-2cduA:undetectable | 3t3sD-2cduA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dre | WATER-SOLUBLECHLOROPHYLL PROTEIN (Lepidiumvirginicum) |
PF00197(Kunitz_legume) | 4 | ASN A 80PHE A 122ALA A 82THR A 97 | None | 0.83A | 3t3sD-2dreA:undetectable | 3t3sD-2dreA:16.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2es3 | THROMBOSPONDIN-1 (Homo sapiens) |
PF02210(Laminin_G_2) | 4 | PHE A 169ALA A 177PHE A 99ALA A 88 | None | 0.89A | 3t3sD-2es3A:undetectable | 3t3sD-2es3A:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kdy | FACTOR H BINDINGPROTEIN VARIANTB01_001 (Neisseriameningitidis) |
PF08794(Lipoprot_C) | 4 | PHE A 135ALA A 162PHE A 163ALA A 244 | None | 0.85A | 3t3sD-2kdyA:undetectable | 3t3sD-2kdyA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nqo | GAMMA-GLUTAMYLTRANSPEPTIDASE (Helicobacterpylori) |
PF01019(G_glu_transpept) | 4 | PHE A 197ALA A 183PHE A 187ALA A 78 | None | 0.91A | 3t3sD-2nqoA:undetectable | 3t3sD-2nqoA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o5h | HYPOTHETICAL PROTEIN (Neisseriameningitidis) |
PF04591(DUF596) | 4 | PHE A 56PHE A 53PHE A 52ALA A 115 | None | 0.90A | 3t3sD-2o5hA:undetectable | 3t3sD-2o5hA:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p2s | PUTATIVEOXIDOREDUCTASE (Pectobacteriumatrosepticum) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | PHE A 297ALA A 28PHE A 93ALA A 70 | None | 0.88A | 3t3sD-2p2sA:undetectable | 3t3sD-2p2sA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pb0 | ACETYLORNITHINE/SUCCINYLDIAMINOPIMELATEAMINOTRANSFERASE (Salmonellaenterica) |
PF00202(Aminotran_3) | 4 | PHE A 332ALA A 324PHE A 396ALA A 397 | None | 0.94A | 3t3sD-2pb0A:undetectable | 3t3sD-2pb0A:21.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2pg6 | CYTOCHROME P450 2A6 (Homo sapiens) |
PF00067(p450) | 4 | PHE A 107PHE A 111PHE A 118THR A 305 | NoneNoneNoneHEM A 500 (-3.6A) | 0.45A | 3t3sD-2pg6A:61.6 | 3t3sD-2pg6A:94.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pv4 | UNCHARACTERIZEDPROTEIN (Shewanellaamazonensis) |
PF11269(DUF3069) | 5 | PHE A 72PHE A 75ALA A 78ASN A 79ALA A 117 | None | 1.32A | 3t3sD-2pv4A:undetectable | 3t3sD-2pv4A:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2px7 | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATECYTIDYLYLTRANSFERASE (Thermusthermophilus) |
PF01128(IspD) | 4 | PHE A 63ALA A 53ALA A 22THR A 30 | None | 0.95A | 3t3sD-2px7A:undetectable | 3t3sD-2px7A:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r1f | PREDICTEDAMINODEOXYCHORISMATELYASE (Escherichiacoli) |
PF02618(YceG) | 4 | PHE A 306PHE A 316PHE A 232ALA A 229 | GOL A 350 (-3.8A)NoneGOL A 350 (-4.8A)None | 0.89A | 3t3sD-2r1fA:undetectable | 3t3sD-2r1fA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wrz | L-ARABINOSE-BINDINGPERIPLASMIC PROTEIN (Escherichiacoli) |
PF00532(Peripla_BP_1) | 4 | ALA A 215ASN A 187ALA A 185THR A 174 | None | 0.95A | 3t3sD-2wrzA:undetectable | 3t3sD-2wrzA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wtg | GLOBIN-LIKE PROTEIN (Caenorhabditiselegans) |
PF00042(Globin) | 4 | PHE A 118PHE A 115PHE A 114ALA A 76 | NoneNoneHEM A 180 (-3.7A)HEM A 180 (-3.6A) | 0.86A | 3t3sD-2wtgA:undetectable | 3t3sD-2wtgA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y3a | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT BETA ISOFORM (Mus musculus) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd)PF02192(PI3K_p85B) | 5 | PHE A1039PHE A1035PHE A 952ALA A 900THR A 896 | None | 1.41A | 3t3sD-2y3aA:undetectable | 3t3sD-2y3aA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zf5 | GLYCEROL KINASE (Thermococcuskodakarensis) |
PF00370(FGGY_N)PF02782(FGGY_C) | 4 | PHE O 412ALA O 326PHE O 408ALA O 372 | None | 0.91A | 3t3sD-2zf5O:undetectable | 3t3sD-2zf5O:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzr | UNSATURATEDGLUCURONYL HYDROLASE (Streptococcusagalactiae) |
PF07470(Glyco_hydro_88) | 4 | ALA A 143PHE A 185ALA A 186THR A 190 | None | 0.84A | 3t3sD-2zzrA:undetectable | 3t3sD-2zzrA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahi | XYLULOSE5-PHOSPHATE/FRUCTOSE6-PHOSPHATEPHOSPHOKETOLASE (Bifidobacteriumbreve) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 4 | PHE A 729ALA A 645PHE A 707ALA A 625 | None | 0.93A | 3t3sD-3ahiA:undetectable | 3t3sD-3ahiA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai7 | XYLULOSE-5-PHOSPHATE/FRUCTOSE-6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacteriumlongum) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 4 | PHE A 729ALA A 645PHE A 707ALA A 625 | None | 0.94A | 3t3sD-3ai7A:undetectable | 3t3sD-3ai7A:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3al0 | ASPARTYL/GLUTAMYL-TRNA(ASN/GLN)AMIDOTRANSFERASESUBUNIT B (Thermotogamaritima) |
PF02637(GatB_Yqey)PF02934(GatB_N) | 4 | PHE B 376PHE B 380PHE B 397THR B 353 | NoneNoneNone G E 53 ( 4.1A) | 0.90A | 3t3sD-3al0B:undetectable | 3t3sD-3al0B:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bjd | PUTATIVE3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE (Pseudomonasaeruginosa) |
PF14515(HOASN)PF14518(Haem_oxygenas_2) | 4 | PHE A 108ALA A 97ASN A 300PHE A 298 | None | 0.89A | 3t3sD-3bjdA:undetectable | 3t3sD-3bjdA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cio | TYROSINE-PROTEINKINASE ETK (Escherichiacoli) |
PF13614(AAA_31) | 4 | PHE A 604ALA A 553PHE A 609ALA A 503 | None | 0.90A | 3t3sD-3cioA:undetectable | 3t3sD-3cioA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cn7 | CARBOXYLESTERASE (Pseudomonasaeruginosa) |
PF02230(Abhydrolase_2) | 4 | PHE A 124ALA A 141PHE A 144ALA A 136 | None | 0.88A | 3t3sD-3cn7A:undetectable | 3t3sD-3cn7A:16.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d45 | POLY(A)-SPECIFICRIBONUCLEASE PARN (Mus musculus) |
PF01424(R3H)PF04857(CAF1)PF08675(RNA_bind) | 4 | PHE A 69PHE A 90PHE A 263ALA A 269 | None | 0.87A | 3t3sD-3d45A:undetectable | 3t3sD-3d45A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dde | TENA/THI-4 PROTEIN,DOMAIN OF UNKNOWNFUNCTION WITH A HEMEOXYGENASE-LIKE FOLD (Shewanelladenitrificans) |
PF14518(Haem_oxygenas_2) | 4 | PHE A 167ALA A 90PHE A 166THR A 113 | None | 0.78A | 3t3sD-3ddeA:undetectable | 3t3sD-3ddeA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dr2 | EXPORTEDGLUCONOLACTONASE (Xanthomonascampestris) |
PF08450(SGL) | 4 | PHE A 244ALA A 234ALA A 219THR A 201 | None | 0.93A | 3t3sD-3dr2A:undetectable | 3t3sD-3dr2A:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dr5 | PUTATIVEO-METHYLTRANSFERASE (Corynebacteriumglutamicum) |
PF13578(Methyltransf_24) | 4 | PHE A 101ALA A 25ALA A 66THR A 64 | None | 0.93A | 3t3sD-3dr5A:undetectable | 3t3sD-3dr5A:19.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3e4e | CYTOCHROME P450 2E1 (Homo sapiens) |
PF00067(p450) | 5 | PHE A 106PHE A 116PHE A 298ALA A 299THR A 303 | NoneNoneNoneHEM A 500 ( 3.3A)4PZ A 501 ( 2.8A) | 1.28A | 3t3sD-3e4eA:55.6 | 3t3sD-3e4eA:51.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g3z | TRANSCRIPTIONALREGULATOR, MARRFAMILY (Neisseriameningitidis) |
PF01047(MarR) | 4 | PHE A 18PHE A 32ALA A 33THR A 37 | None | 0.82A | 3t3sD-3g3zA:undetectable | 3t3sD-3g3zA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3grn | MUTT RELATED PROTEIN (Methanosarcinamazei) |
PF00293(NUDIX) | 4 | PHE A 133PHE A 130PHE A 129ALA A 13 | None | 0.88A | 3t3sD-3grnA:undetectable | 3t3sD-3grnA:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gsi | N,N-DIMETHYLGLYCINEOXIDASE (Arthrobacterglobiformis) |
PF01266(DAO)PF01571(GCV_T)PF08669(GCV_T_C)PF16350(FAO_M) | 4 | ASN A 57PHE A 65ALA A 66THR A 69 | None | 0.84A | 3t3sD-3gsiA:undetectable | 3t3sD-3gsiA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jvi | PROTEIN TYROSINEPHOSPHATASE (Entamoebahistolytica) |
PF01451(LMWPc) | 5 | PHE A 84ALA A 17PHE A 5PHE A 112ALA A 142 | None | 1.32A | 3t3sD-3jviA:undetectable | 3t3sD-3jviA:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k13 | 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINEMETHYLTRANSFERASE (Bacteroidesthetaiotaomicron) |
PF00809(Pterin_bind) | 4 | ASN A 561PHE A 564ALA A 524THR A 527 | THH A 642 ( 3.3A)NoneNoneNone | 0.92A | 3t3sD-3k13A:undetectable | 3t3sD-3k13A:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k70 | EXODEOXYRIBONUCLEASEV BETA CHAIN (Escherichiacoli) |
PF00580(UvrD-helicase)PF12705(PDDEXK_1)PF13361(UvrD_C) | 5 | PHE B 475PHE B 461PHE B 468ALA B 25THR B 27 | None | 1.45A | 3t3sD-3k70B:undetectable | 3t3sD-3k70B:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3klu | UNCHARACTERIZEDPROTEIN YQBN (Bacillussubtilis) |
PF08890(Phage_TAC_5) | 4 | PHE A 44ALA A 130PHE A 46PHE A 95 | None | 0.93A | 3t3sD-3kluA:undetectable | 3t3sD-3kluA:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kxe | ANTITOXIN PROTEINPARD-1TOXIN PROTEIN PARE-1 (Caulobactervibrioides) |
PF03693(ParD_antitoxin)PF05016(ParE_toxin) | 4 | PHE C 72PHE C 69PHE C 67ALA A 10 | None | 0.84A | 3t3sD-3kxeC:undetectable | 3t3sD-3kxeC:12.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzp | PUTATIVE DIGUANYLATECYCLASE/PHOSPHODIESTERASE (Listeriamonocytogenes) |
PF00563(EAL) | 4 | PHE A 59PHE A 55ALA A 80THR A 108 | None | 0.89A | 3t3sD-3kzpA:undetectable | 3t3sD-3kzpA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l76 | ASPARTOKINASE (Synechocystissp. PCC 6803) |
PF00696(AA_kinase)PF01842(ACT)PF13840(ACT_7) | 4 | ALA A 587PHE A 588PHE A 548ALA A 549 | None | 0.80A | 3t3sD-3l76A:undetectable | 3t3sD-3l76A:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lki | FRUCTOKINASE (Xylellafastidiosa) |
PF00294(PfkB) | 5 | PHE A 130ALA A 164PHE A 135PHE A 18ALA A 143 | None | 1.35A | 3t3sD-3lkiA:undetectable | 3t3sD-3lkiA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3llq | AQUAPORIN Z 2 (Agrobacteriumfabrum) |
PF00230(MIP) | 4 | ALA A 65ASN A 63ALA A 186THR A 189 | None | 0.93A | 3t3sD-3llqA:undetectable | 3t3sD-3llqA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lye | OXALOACETATE ACETYLHYDROLASE (Cryphonectriaparasitica) |
PF13714(PEP_mutase) | 4 | ALA A 102PHE A 107PHE A 307ALA A 310 | None | 0.93A | 3t3sD-3lyeA:undetectable | 3t3sD-3lyeA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o53 | PROTEIN LRIM1 (Anophelesgambiae) |
PF00560(LRR_1)PF13855(LRR_8) | 5 | PHE A 264PHE A 257ASN A 283PHE A 280THR A 275 | None | 1.50A | 3t3sD-3o53A:undetectable | 3t3sD-3o53A:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p27 | ELONGATION FACTOR 1ALPHA-LIKE PROTEIN (Saccharomycescerevisiae) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3) | 4 | PHE A 170ALA A 384ALA A 245THR A 242 | None | 0.84A | 3t3sD-3p27A:undetectable | 3t3sD-3p27A:22.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pm0 | CYTOCHROME P450 1B1 (Homo sapiens) |
PF00067(p450) | 4 | ALA A 133PHE A 134ALA A 330THR A 334 | HEM A 900 (-3.3A)BHF A 800 (-4.8A)HEM A 900 ( 3.4A)HEM A 900 ( 3.2A) | 0.58A | 3t3sD-3pm0A:40.6 | 3t3sD-3pm0A:33.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pxp | HELIX-TURN-HELIXDOMAIN PROTEIN (Chloroflexusaurantiacus) |
PF13560(HTH_31) | 4 | PHE A 155PHE A 206ALA A 213THR A 67 | None | 0.92A | 3t3sD-3pxpA:undetectable | 3t3sD-3pxpA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r4d | SPIKE GLYCOPROTEIN (Murinecoronavirus) |
PF16451(Spike_NTD) | 4 | PHE B 204ALA B 215PHE B 206ALA B 150 | None | 0.95A | 3t3sD-3r4dB:undetectable | 3t3sD-3r4dB:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sbu | HYPOTHETICALNTF2-LIKE PROTEIN (Bacteroidesfragilis) |
PF14254(DUF4348) | 4 | PHE A 152PHE A 64PHE A 71ALA A 72 | None | 0.85A | 3t3sD-3sbuA:undetectable | 3t3sD-3sbuA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sbu | HYPOTHETICALNTF2-LIKE PROTEIN (Bacteroidesfragilis) |
PF14254(DUF4348) | 4 | PHE A 267PHE A 177PHE A 184ALA A 185 | None | 0.70A | 3t3sD-3sbuA:undetectable | 3t3sD-3sbuA:19.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tk3 | CYTOCHROME P450 2B4 (Oryctolaguscuniculus) |
PF00067(p450) | 4 | PHE A 108PHE A 115ALA A 298THR A 302 | NoneNoneCPZ A 501 (-3.5A)CPZ A 501 ( 3.7A) | 0.65A | 3t3sD-3tk3A:55.6 | 3t3sD-3tk3A:56.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqc | PANTOTHENATE KINASE (Coxiellaburnetii) |
PF00485(PRK) | 4 | PHE A 260PHE A 253PHE A 274ALA A 275 | None | 0.86A | 3t3sD-3tqcA:undetectable | 3t3sD-3tqcA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wz4 | DOTI (Legionellapneumophila) |
PF11393(T4BSS_DotI_IcmL) | 4 | PHE A 202PHE A 116PHE A 108ALA A 88 | None | 0.91A | 3t3sD-3wz4A:undetectable | 3t3sD-3wz4A:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zdr | ALCOHOLDEHYDROGENASE DOMAINOF THE BIFUNCTIONALACETALDEHYDEDEHYDROGENASE (Parageobacillusthermoglucosidasius) |
PF00465(Fe-ADH) | 4 | ALA A 848ASN A 673ALA A 675THR A 679 | CSO A 845 ( 3.9A)NoneNoneNone | 0.82A | 3t3sD-3zdrA:undetectable | 3t3sD-3zdrA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ae5 | SIGNAL TRANSDUCTIONPROTEIN TRAP (Staphylococcusaureus) |
no annotation | 4 | PHE A 118PHE A 120PHE A 94ALA A 134 | None | 0.87A | 3t3sD-4ae5A:undetectable | 3t3sD-4ae5A:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4amc | GLUCANSUCRASE (Lactobacillusreuteri) |
PF01473(CW_binding_1)PF02324(Glyco_hydro_70) | 4 | PHE A1439ALA A1413PHE A1447ALA A1428 | None | 0.90A | 3t3sD-4amcA:undetectable | 3t3sD-4amcA:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ay9 | FOLLICLE-STIMULATINGHORMONE RECEPTOR (Homo sapiens) |
PF01462(LRRNT)PF12369(GnHR_trans)PF13306(LRR_5) | 4 | PHE X 91ALA X 65PHE X 66THR X 56 | None | 0.87A | 3t3sD-4ay9X:undetectable | 3t3sD-4ay9X:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bfr | PHOSPHATIDYLINOSITOL4,5-BISPHOSPHATE3-KINASE CATALYTIC SSUBUNIT BETA ISOFORM (Mus musculus) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd) | 5 | PHE A1039PHE A1035PHE A 952ALA A 900THR A 896 | None | 1.49A | 3t3sD-4bfrA:undetectable | 3t3sD-4bfrA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgu | MALATE DEHYDROGENASE (Haloferaxvolcanii) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | ALA A 231ASN A 20ALA A 22THR A 59 | None CL A1326 (-3.0A)NoneNone | 0.80A | 3t3sD-4bguA:undetectable | 3t3sD-4bguA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e72 | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF11738(DUF3298) | 4 | PHE A 167ALA A 174ALA A 208THR A 205 | None | 0.88A | 3t3sD-4e72A:undetectable | 3t3sD-4e72A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eay | MANNONATEDEHYDRATASE (Escherichiacoli) |
PF03786(UxuA) | 4 | ASN A 211PHE A 212ALA A 213THR A 260 | None | 0.94A | 3t3sD-4eayA:undetectable | 3t3sD-4eayA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iug | BETA-GALACTOSIDASE A (Aspergillusoryzae) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 4 | PHE A 910PHE A 975PHE A 896ALA A 894 | None | 0.90A | 3t3sD-4iugA:undetectable | 3t3sD-4iugA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9t | DESIGNED UNNATURALAMINO ACID DEPENDENTMETALLOPROTEIN (Micromonosporaviridifaciens) |
PF13088(BNR_2) | 4 | ALA A 226PHE A 203ALA A 276THR A 309 | None | 0.93A | 3t3sD-4j9tA:undetectable | 3t3sD-4j9tA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k2a | HALOALKANEDEHALOGENASE (Bradyrhizobiumelkanii) |
PF00561(Abhydrolase_1) | 4 | PHE A 125PHE A 110ALA A 229THR A 257 | None | 0.94A | 3t3sD-4k2aA:undetectable | 3t3sD-4k2aA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpn | NUCLEOSIDEN-RIBOHYDROLASE 1 (Physcomitrellapatens) |
PF01156(IU_nuc_hydro) | 5 | PHE A 70ALA A 31PHE A 35ALA A 237THR A 107 | None | 1.25A | 3t3sD-4kpnA:undetectable | 3t3sD-4kpnA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mjf | HYPOTHETICAL PROTEIN (Bacteroidesvulgatus) |
PF14254(DUF4348) | 4 | PHE A 152PHE A 64PHE A 71ALA A 72 | NoneCXS A 300 ( 4.9A)NoneEDO A 307 ( 3.9A) | 0.72A | 3t3sD-4mjfA:undetectable | 3t3sD-4mjfA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mjf | HYPOTHETICAL PROTEIN (Bacteroidesvulgatus) |
PF14254(DUF4348) | 4 | PHE A 269PHE A 179PHE A 186ALA A 187 | None | 0.82A | 3t3sD-4mjfA:undetectable | 3t3sD-4mjfA:21.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nky | STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) |
PF00067(p450) | 4 | ALA A 113PHE A 114ALA A 302THR A 306 | HEM A 600 ( 2.9A)3QZ A 601 ( 4.1A)3QZ A 601 (-2.9A)HEM A 600 ( 3.2A) | 0.51A | 3t3sD-4nkyA:43.6 | 3t3sD-4nkyA:31.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4opu | CONSERVED ARCHAEALPROTEIN (Sulfolobusacidocaldarius) |
PF01266(DAO) | 4 | PHE A 353PHE A 350ALA A 413ALA A 393 | None | 0.91A | 3t3sD-4opuA:undetectable | 3t3sD-4opuA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r1z | CYP17A1 PROTEIN (Danio rerio) |
PF00067(p450) | 4 | ALA A 126PHE A 127ALA A 313THR A 317 | HEM A 600 (-3.6A)NoneHEM A 600 (-3.5A)HEM A 600 ( 3.3A) | 0.72A | 3t3sD-4r1zA:42.4 | 3t3sD-4r1zA:29.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4r20 | CYTOCHROME P450FAMILY 17POLYPEPTIDE 2 (Danio rerio) |
PF00067(p450) | 4 | ALA A 120PHE A 121ALA A 302THR A 306 | AER A 602 (-3.7A)NoneHEM A 601 (-3.4A)HEM A 601 ( 3.3A) | 0.55A | 3t3sD-4r20A:41.8 | 3t3sD-4r20A:33.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r4z | PNGF-II (Elizabethkingiameningoseptica) |
PF09112(N-glycanase_N)PF09113(N-glycanase_C) | 4 | PHE A 65PHE A 46ALA A 44PHE A 48 | None | 0.94A | 3t3sD-4r4zA:undetectable | 3t3sD-4r4zA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rc6 | ALDEHYDEDECARBONYLASE (Synechococcuselongatus) |
PF11266(Ald_deCOase) | 4 | PHE B 87ALA B 35PHE B 117ALA B 118 | NoneFE2 B 301 ( 4.3A)NoneNone | 0.91A | 3t3sD-4rc6B:undetectable | 3t3sD-4rc6B:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rph | UDP-GALACTOPYRANOSEMUTASE (Mycobacteriumtuberculosis) |
no annotation | 4 | ALA B 93PHE B 102ASN B 284ALA B 156 | NoneGDU B 402 (-3.9A)GDU B 402 (-3.6A)None | 0.90A | 3t3sD-4rphB:undetectable | 3t3sD-4rphB:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zwj | CHIMERA PROTEIN OFHUMAN RHODOPSIN,MOUSE S-ARRESTIN,AND T4 ENDOLYSIN (Escherichiavirus T4;Homo sapiens;Mus musculus) |
PF00001(7tm_1)PF00339(Arrestin_N)PF00959(Phage_lysozyme)PF02752(Arrestin_C)PF10413(Rhodopsin_N) | 4 | PHE A 261ALA A 298ASN A 302ALA A 124 | None | 0.80A | 3t3sD-4zwjA:undetectable | 3t3sD-4zwjA:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aex | AMMONIUM TRANSPORTERMEP2 (Saccharomycescerevisiae) |
PF00909(Ammonium_transp) | 5 | ALA A 88PHE A 89PHE A 132ALA A 133THR A 136 | None | 1.26A | 3t3sD-5aexA:undetectable | 3t3sD-5aexA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aex | AMMONIUM TRANSPORTERMEP2 (Saccharomycescerevisiae) |
PF00909(Ammonium_transp) | 5 | PHE A 125PHE A 89PHE A 132ALA A 133THR A 136 | None | 1.30A | 3t3sD-5aexA:undetectable | 3t3sD-5aexA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b1u | METALLO-BETA-LACTAMASE (Serratiamarcescens) |
PF00753(Lactamase_B) | 4 | ALA A 241ASN A 219ALA A 173THR A 156 | None | 0.71A | 3t3sD-5b1uA:undetectable | 3t3sD-5b1uA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5btr | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 4 | PHE A 273ALA A 313PHE A 312THR A 349 | None | 0.92A | 3t3sD-5btrA:undetectable | 3t3sD-5btrA:21.30 |