SIMILAR PATTERNS OF AMINO ACIDS FOR 3T3S_D_9PLD1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aur CARBOXYLESTERASE

(Pseudomonas
fluorescens)
PF02230
(Abhydrolase_2)
4 PHE A 125
ALA A 142
PHE A 145
ALA A 137
None
0.92A 3t3sD-1aurA:
undetectable
3t3sD-1aurA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek2 EPOXIDE HYDROLASE

(Mus musculus)
PF00561
(Abhydrolase_1)
PF13419
(HAD_2)
4 ALA A 108
PHE A 221
PHE A 117
ALA A   6
None
0.85A 3t3sD-1ek2A:
undetectable
3t3sD-1ek2A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli)
PF00149
(Metallophos)
PF02872
(5_nucleotid_C)
4 ALA A 464
ASN A 465
ALA A 399
THR A 397
None
0.90A 3t3sD-1hp1A:
undetectable
3t3sD-1hp1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II


(Thermus
thermophilus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 PHE A 258
ALA A 280
ALA A 162
THR A 159
None
0.93A 3t3sD-1j3nA:
undetectable
3t3sD-1j3nA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
4 PHE A 250
ALA A 305
PHE A 235
ALA A 410
None
0.86A 3t3sD-1kfiA:
undetectable
3t3sD-1kfiA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylococcus
capsulatus)
PF02332
(Phenol_Hydrox)
5 PHE B 335
ALA B 227
PHE B 256
ASN B 155
ALA B 151
None
1.38A 3t3sD-1mtyB:
undetectable
3t3sD-1mtyB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n2m PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE


(Methanocaldococcus
jannaschii)
PF01862
(PvlArgDC)
4 PHE A  34
ALA A  41
ALA A 159
THR A  75
MRD  A7006 ( 3.9A)
None
None
None
0.94A 3t3sD-1n2mA:
undetectable
3t3sD-1n2mA:
15.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus)
PF00067
(p450)
4 ALA A 113
PHE A 114
ALA A 294
THR A 298
DIF  A 501 (-3.6A)
DIF  A 501 (-4.5A)
DIF  A 501 ( 3.3A)
HEM  A 500 ( 3.6A)
0.78A 3t3sD-1nr6A:
49.4
3t3sD-1nr6A:
54.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7x CITRATE SYNTHASE

(Sulfolobus
solfataricus)
PF00285
(Citrate_synt)
5 PHE A 325
PHE A 320
ALA A 172
PHE A 156
ALA A 153
None
1.36A 3t3sD-1o7xA:
0.4
3t3sD-1o7xA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus)
PF06407
(BDV_P40)
5 ALA X 329
ASN X 301
PHE X 299
ALA X 303
THR X 237
None
1.04A 3t3sD-1pp1X:
undetectable
3t3sD-1pp1X:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
4 ALA A 177
PHE A 178
ALA A 140
THR A 341
None
ZN  A 402 ( 4.8A)
None
None
0.90A 3t3sD-1pv9A:
undetectable
3t3sD-1pv9A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus)
PF00405
(Transferrin)
4 PHE A 487
ALA A 492
PHE A 542
ALA A 466
None
None
None
CO3  A 693 (-4.0A)
0.94A 3t3sD-1qjmA:
undetectable
3t3sD-1qjmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE


(Yersinia
pseudotuberculosis)
PF16363
(GDP_Man_Dehyd)
4 ALA A  89
ASN A 107
ALA A 164
THR A 168
NAD  A 360 (-3.3A)
None
None
None
0.88A 3t3sD-1rkxA:
undetectable
3t3sD-1rkxA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER


(Escherichia
coli)
PF00909
(Ammonium_transp)
4 ALA A  67
PHE A 107
ALA A 108
THR A 111
None
NH4  A 404 (-3.9A)
None
None
0.79A 3t3sD-1u7gA:
undetectable
3t3sD-1u7gA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u9z RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE


(Methanocaldococcus
jannaschii)
PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N)
4 ALA A  62
ASN A  54
ALA A  85
THR A 121
None
0.94A 3t3sD-1u9zA:
undetectable
3t3sD-1u9zA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhn PUTATIVE FLAVIN
OXIDOREDUCTASE


(Thermotoga
maritima)
PF01207
(Dus)
4 ALA A  24
PHE A 223
PHE A  31
ALA A  32
None
0.89A 3t3sD-1vhnA:
undetectable
3t3sD-1vhnA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE


(Penicillium
simplicissimum)
PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C)
4 PHE A 353
ALA A 374
PHE A 375
ALA A 304
None
0.87A 3t3sD-1w1kA:
undetectable
3t3sD-1w1kA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE


(Pyrococcus
furiosus)
PF00557
(Peptidase_M24)
4 ALA A  49
PHE A  50
ALA A  13
THR A 294
None
MET  A1298 (-3.8A)
None
None
0.83A 3t3sD-1wkmA:
undetectable
3t3sD-1wkmA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy2 XAA-PRO DIPEPTIDASE

(Pyrococcus
horikoshii)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
4 ALA A 180
PHE A 181
ALA A 143
THR A 344
None
CAC  A 403 (-3.7A)
None
None
0.91A 3t3sD-1wy2A:
undetectable
3t3sD-1wy2A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR


(Homo sapiens)
PF01462
(LRRNT)
PF13306
(LRR_5)
4 PHE C  91
ALA C  65
PHE C  66
THR C  56
None
0.69A 3t3sD-1xwdC:
undetectable
3t3sD-1xwdC:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2i AMMONIUM TRANSPORTER

(Archaeoglobus
fulgidus)
PF00909
(Ammonium_transp)
5 PHE A  89
PHE A  63
PHE A  96
ALA A  97
THR A 100
None
1.37A 3t3sD-2b2iA:
undetectable
3t3sD-2b2iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8s CYTOCHROME C-L

(Methylobacterium
extorquens)
PF13442
(Cytochrome_CBB3)
4 PHE A  98
ASN A  45
ALA A  35
THR A  33
None
0.92A 3t3sD-2c8sA:
undetectable
3t3sD-2c8sA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cas CANINE PARVOVIRUS
EMPTY CAPSID (STRAIN
D) VIRAL PROTEIN 2


(Carnivore
protoparvovirus
1)
PF00740
(Parvo_coat)
4 ALA A 486
ASN A 485
ALA A 189
THR A 194
None
0.69A 3t3sD-2casA:
undetectable
3t3sD-2casA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 ALA A  11
PHE A 278
ALA A 279
THR A 266
FAD  A 500 (-3.5A)
None
None
None
0.87A 3t3sD-2cduA:
undetectable
3t3sD-2cduA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dre WATER-SOLUBLE
CHLOROPHYLL PROTEIN


(Lepidium
virginicum)
PF00197
(Kunitz_legume)
4 ASN A  80
PHE A 122
ALA A  82
THR A  97
None
0.83A 3t3sD-2dreA:
undetectable
3t3sD-2dreA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2es3 THROMBOSPONDIN-1

(Homo sapiens)
PF02210
(Laminin_G_2)
4 PHE A 169
ALA A 177
PHE A  99
ALA A  88
None
0.89A 3t3sD-2es3A:
undetectable
3t3sD-2es3A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kdy FACTOR H BINDING
PROTEIN VARIANT
B01_001


(Neisseria
meningitidis)
PF08794
(Lipoprot_C)
4 PHE A 135
ALA A 162
PHE A 163
ALA A 244
None
0.85A 3t3sD-2kdyA:
undetectable
3t3sD-2kdyA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqo GAMMA-GLUTAMYLTRANSP
EPTIDASE


(Helicobacter
pylori)
PF01019
(G_glu_transpept)
4 PHE A 197
ALA A 183
PHE A 187
ALA A  78
None
0.91A 3t3sD-2nqoA:
undetectable
3t3sD-2nqoA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5h HYPOTHETICAL PROTEIN

(Neisseria
meningitidis)
PF04591
(DUF596)
4 PHE A  56
PHE A  53
PHE A  52
ALA A 115
None
0.90A 3t3sD-2o5hA:
undetectable
3t3sD-2o5hA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2s PUTATIVE
OXIDOREDUCTASE


(Pectobacterium
atrosepticum)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 PHE A 297
ALA A  28
PHE A  93
ALA A  70
None
0.88A 3t3sD-2p2sA:
undetectable
3t3sD-2p2sA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE


(Salmonella
enterica)
PF00202
(Aminotran_3)
4 PHE A 332
ALA A 324
PHE A 396
ALA A 397
None
0.94A 3t3sD-2pb0A:
undetectable
3t3sD-2pb0A:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens)
PF00067
(p450)
4 PHE A 107
PHE A 111
PHE A 118
THR A 305
None
None
None
HEM  A 500 (-3.6A)
0.45A 3t3sD-2pg6A:
61.6
3t3sD-2pg6A:
94.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pv4 UNCHARACTERIZED
PROTEIN


(Shewanella
amazonensis)
PF11269
(DUF3069)
5 PHE A  72
PHE A  75
ALA A  78
ASN A  79
ALA A 117
None
1.32A 3t3sD-2pv4A:
undetectable
3t3sD-2pv4A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE


(Thermus
thermophilus)
PF01128
(IspD)
4 PHE A  63
ALA A  53
ALA A  22
THR A  30
None
0.95A 3t3sD-2px7A:
undetectable
3t3sD-2px7A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE


(Escherichia
coli)
PF02618
(YceG)
4 PHE A 306
PHE A 316
PHE A 232
ALA A 229
GOL  A 350 (-3.8A)
None
GOL  A 350 (-4.8A)
None
0.89A 3t3sD-2r1fA:
undetectable
3t3sD-2r1fA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN


(Escherichia
coli)
PF00532
(Peripla_BP_1)
4 ALA A 215
ASN A 187
ALA A 185
THR A 174
None
0.95A 3t3sD-2wrzA:
undetectable
3t3sD-2wrzA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtg GLOBIN-LIKE PROTEIN

(Caenorhabditis
elegans)
PF00042
(Globin)
4 PHE A 118
PHE A 115
PHE A 114
ALA A  76
None
None
HEM  A 180 (-3.7A)
HEM  A 180 (-3.6A)
0.86A 3t3sD-2wtgA:
undetectable
3t3sD-2wtgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM


(Mus musculus)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
5 PHE A1039
PHE A1035
PHE A 952
ALA A 900
THR A 896
None
1.41A 3t3sD-2y3aA:
undetectable
3t3sD-2y3aA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
4 PHE O 412
ALA O 326
PHE O 408
ALA O 372
None
0.91A 3t3sD-2zf5O:
undetectable
3t3sD-2zf5O:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE


(Streptococcus
agalactiae)
PF07470
(Glyco_hydro_88)
4 ALA A 143
PHE A 185
ALA A 186
THR A 190
None
0.84A 3t3sD-2zzrA:
undetectable
3t3sD-2zzrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE


(Bifidobacterium
breve)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
4 PHE A 729
ALA A 645
PHE A 707
ALA A 625
None
0.93A 3t3sD-3ahiA:
undetectable
3t3sD-3ahiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE


(Bifidobacterium
longum)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
4 PHE A 729
ALA A 645
PHE A 707
ALA A 625
None
0.94A 3t3sD-3ai7A:
undetectable
3t3sD-3ai7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B


(Thermotoga
maritima)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
4 PHE B 376
PHE B 380
PHE B 397
THR B 353
None
None
None
G  E  53 ( 4.1A)
0.90A 3t3sD-3al0B:
undetectable
3t3sD-3al0B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjd PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE


(Pseudomonas
aeruginosa)
PF14515
(HOASN)
PF14518
(Haem_oxygenas_2)
4 PHE A 108
ALA A  97
ASN A 300
PHE A 298
None
0.89A 3t3sD-3bjdA:
undetectable
3t3sD-3bjdA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cio TYROSINE-PROTEIN
KINASE ETK


(Escherichia
coli)
PF13614
(AAA_31)
4 PHE A 604
ALA A 553
PHE A 609
ALA A 503
None
0.90A 3t3sD-3cioA:
undetectable
3t3sD-3cioA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cn7 CARBOXYLESTERASE

(Pseudomonas
aeruginosa)
PF02230
(Abhydrolase_2)
4 PHE A 124
ALA A 141
PHE A 144
ALA A 136
None
0.88A 3t3sD-3cn7A:
undetectable
3t3sD-3cn7A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN


(Mus musculus)
PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind)
4 PHE A  69
PHE A  90
PHE A 263
ALA A 269
None
0.87A 3t3sD-3d45A:
undetectable
3t3sD-3d45A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dde TENA/THI-4 PROTEIN,
DOMAIN OF UNKNOWN
FUNCTION WITH A HEME
OXYGENASE-LIKE FOLD


(Shewanella
denitrificans)
PF14518
(Haem_oxygenas_2)
4 PHE A 167
ALA A  90
PHE A 166
THR A 113
None
0.78A 3t3sD-3ddeA:
undetectable
3t3sD-3ddeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE


(Xanthomonas
campestris)
PF08450
(SGL)
4 PHE A 244
ALA A 234
ALA A 219
THR A 201
None
0.93A 3t3sD-3dr2A:
undetectable
3t3sD-3dr2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr5 PUTATIVE
O-METHYLTRANSFERASE


(Corynebacterium
glutamicum)
PF13578
(Methyltransf_24)
4 PHE A 101
ALA A  25
ALA A  66
THR A  64
None
0.93A 3t3sD-3dr5A:
undetectable
3t3sD-3dr5A:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e4e CYTOCHROME P450 2E1

(Homo sapiens)
PF00067
(p450)
5 PHE A 106
PHE A 116
PHE A 298
ALA A 299
THR A 303
None
None
None
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
1.28A 3t3sD-3e4eA:
55.6
3t3sD-3e4eA:
51.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3z TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY


(Neisseria
meningitidis)
PF01047
(MarR)
4 PHE A  18
PHE A  32
ALA A  33
THR A  37
None
0.82A 3t3sD-3g3zA:
undetectable
3t3sD-3g3zA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grn MUTT RELATED PROTEIN

(Methanosarcina
mazei)
PF00293
(NUDIX)
4 PHE A 133
PHE A 130
PHE A 129
ALA A  13
None
0.88A 3t3sD-3grnA:
undetectable
3t3sD-3grnA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE


(Arthrobacter
globiformis)
PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M)
4 ASN A  57
PHE A  65
ALA A  66
THR A  69
None
0.84A 3t3sD-3gsiA:
undetectable
3t3sD-3gsiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvi PROTEIN TYROSINE
PHOSPHATASE


(Entamoeba
histolytica)
PF01451
(LMWPc)
5 PHE A  84
ALA A  17
PHE A   5
PHE A 112
ALA A 142
None
1.32A 3t3sD-3jviA:
undetectable
3t3sD-3jviA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE


(Bacteroides
thetaiotaomicron)
PF00809
(Pterin_bind)
4 ASN A 561
PHE A 564
ALA A 524
THR A 527
THH  A 642 ( 3.3A)
None
None
None
0.92A 3t3sD-3k13A:
undetectable
3t3sD-3k13A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN


(Escherichia
coli)
PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C)
5 PHE B 475
PHE B 461
PHE B 468
ALA B  25
THR B  27
None
1.45A 3t3sD-3k70B:
undetectable
3t3sD-3k70B:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klu UNCHARACTERIZED
PROTEIN YQBN


(Bacillus
subtilis)
PF08890
(Phage_TAC_5)
4 PHE A  44
ALA A 130
PHE A  46
PHE A  95
None
0.93A 3t3sD-3kluA:
undetectable
3t3sD-3kluA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxe ANTITOXIN PROTEIN
PARD-1
TOXIN PROTEIN PARE-1


(Caulobacter
vibrioides)
PF03693
(ParD_antitoxin)
PF05016
(ParE_toxin)
4 PHE C  72
PHE C  69
PHE C  67
ALA A  10
None
0.84A 3t3sD-3kxeC:
undetectable
3t3sD-3kxeC:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE


(Listeria
monocytogenes)
PF00563
(EAL)
4 PHE A  59
PHE A  55
ALA A  80
THR A 108
None
0.89A 3t3sD-3kzpA:
undetectable
3t3sD-3kzpA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803)
PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7)
4 ALA A 587
PHE A 588
PHE A 548
ALA A 549
None
0.80A 3t3sD-3l76A:
undetectable
3t3sD-3l76A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lki FRUCTOKINASE

(Xylella
fastidiosa)
PF00294
(PfkB)
5 PHE A 130
ALA A 164
PHE A 135
PHE A  18
ALA A 143
None
1.35A 3t3sD-3lkiA:
undetectable
3t3sD-3lkiA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llq AQUAPORIN Z 2

(Agrobacterium
fabrum)
PF00230
(MIP)
4 ALA A  65
ASN A  63
ALA A 186
THR A 189
None
0.93A 3t3sD-3llqA:
undetectable
3t3sD-3llqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lye OXALOACETATE ACETYL
HYDROLASE


(Cryphonectria
parasitica)
PF13714
(PEP_mutase)
4 ALA A 102
PHE A 107
PHE A 307
ALA A 310
None
0.93A 3t3sD-3lyeA:
undetectable
3t3sD-3lyeA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o53 PROTEIN LRIM1

(Anopheles
gambiae)
PF00560
(LRR_1)
PF13855
(LRR_8)
5 PHE A 264
PHE A 257
ASN A 283
PHE A 280
THR A 275
None
1.50A 3t3sD-3o53A:
undetectable
3t3sD-3o53A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN


(Saccharomyces
cerevisiae)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
4 PHE A 170
ALA A 384
ALA A 245
THR A 242
None
0.84A 3t3sD-3p27A:
undetectable
3t3sD-3p27A:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens)
PF00067
(p450)
4 ALA A 133
PHE A 134
ALA A 330
THR A 334
HEM  A 900 (-3.3A)
BHF  A 800 (-4.8A)
HEM  A 900 ( 3.4A)
HEM  A 900 ( 3.2A)
0.58A 3t3sD-3pm0A:
40.6
3t3sD-3pm0A:
33.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN


(Chloroflexus
aurantiacus)
PF13560
(HTH_31)
4 PHE A 155
PHE A 206
ALA A 213
THR A  67
None
0.92A 3t3sD-3pxpA:
undetectable
3t3sD-3pxpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4d SPIKE GLYCOPROTEIN

(Murine
coronavirus)
PF16451
(Spike_NTD)
4 PHE B 204
ALA B 215
PHE B 206
ALA B 150
None
0.95A 3t3sD-3r4dB:
undetectable
3t3sD-3r4dB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbu HYPOTHETICAL
NTF2-LIKE PROTEIN


(Bacteroides
fragilis)
PF14254
(DUF4348)
4 PHE A 152
PHE A  64
PHE A  71
ALA A  72
None
0.85A 3t3sD-3sbuA:
undetectable
3t3sD-3sbuA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbu HYPOTHETICAL
NTF2-LIKE PROTEIN


(Bacteroides
fragilis)
PF14254
(DUF4348)
4 PHE A 267
PHE A 177
PHE A 184
ALA A 185
None
0.70A 3t3sD-3sbuA:
undetectable
3t3sD-3sbuA:
19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus)
PF00067
(p450)
4 PHE A 108
PHE A 115
ALA A 298
THR A 302
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
0.65A 3t3sD-3tk3A:
55.6
3t3sD-3tk3A:
56.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqc PANTOTHENATE KINASE

(Coxiella
burnetii)
PF00485
(PRK)
4 PHE A 260
PHE A 253
PHE A 274
ALA A 275
None
0.86A 3t3sD-3tqcA:
undetectable
3t3sD-3tqcA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz4 DOTI

(Legionella
pneumophila)
PF11393
(T4BSS_DotI_IcmL)
4 PHE A 202
PHE A 116
PHE A 108
ALA A  88
None
0.91A 3t3sD-3wz4A:
undetectable
3t3sD-3wz4A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE


(Parageobacillus
thermoglucosidasius)
PF00465
(Fe-ADH)
4 ALA A 848
ASN A 673
ALA A 675
THR A 679
CSO  A 845 ( 3.9A)
None
None
None
0.82A 3t3sD-3zdrA:
undetectable
3t3sD-3zdrA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP


(Staphylococcus
aureus)
no annotation 4 PHE A 118
PHE A 120
PHE A  94
ALA A 134
None
0.87A 3t3sD-4ae5A:
undetectable
3t3sD-4ae5A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri)
PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70)
4 PHE A1439
ALA A1413
PHE A1447
ALA A1428
None
0.90A 3t3sD-4amcA:
undetectable
3t3sD-4amcA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay9 FOLLICLE-STIMULATING
HORMONE RECEPTOR


(Homo sapiens)
PF01462
(LRRNT)
PF12369
(GnHR_trans)
PF13306
(LRR_5)
4 PHE X  91
ALA X  65
PHE X  66
THR X  56
None
0.87A 3t3sD-4ay9X:
undetectable
3t3sD-4ay9X:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM


(Mus musculus)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
5 PHE A1039
PHE A1035
PHE A 952
ALA A 900
THR A 896
None
1.49A 3t3sD-4bfrA:
undetectable
3t3sD-4bfrA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgu MALATE DEHYDROGENASE

(Haloferax
volcanii)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 ALA A 231
ASN A  20
ALA A  22
THR A  59
None
CL  A1326 (-3.0A)
None
None
0.80A 3t3sD-4bguA:
undetectable
3t3sD-4bguA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e72 UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF11738
(DUF3298)
4 PHE A 167
ALA A 174
ALA A 208
THR A 205
None
0.88A 3t3sD-4e72A:
undetectable
3t3sD-4e72A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eay MANNONATE
DEHYDRATASE


(Escherichia
coli)
PF03786
(UxuA)
4 ASN A 211
PHE A 212
ALA A 213
THR A 260
None
0.94A 3t3sD-4eayA:
undetectable
3t3sD-4eayA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae)
PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5)
4 PHE A 910
PHE A 975
PHE A 896
ALA A 894
None
0.90A 3t3sD-4iugA:
undetectable
3t3sD-4iugA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9t DESIGNED UNNATURAL
AMINO ACID DEPENDENT
METALLOPROTEIN


(Micromonospora
viridifaciens)
PF13088
(BNR_2)
4 ALA A 226
PHE A 203
ALA A 276
THR A 309
None
0.93A 3t3sD-4j9tA:
undetectable
3t3sD-4j9tA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2a HALOALKANE
DEHALOGENASE


(Bradyrhizobium
elkanii)
PF00561
(Abhydrolase_1)
4 PHE A 125
PHE A 110
ALA A 229
THR A 257
None
0.94A 3t3sD-4k2aA:
undetectable
3t3sD-4k2aA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1


(Physcomitrella
patens)
PF01156
(IU_nuc_hydro)
5 PHE A  70
ALA A  31
PHE A  35
ALA A 237
THR A 107
None
1.25A 3t3sD-4kpnA:
undetectable
3t3sD-4kpnA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjf HYPOTHETICAL PROTEIN

(Bacteroides
vulgatus)
PF14254
(DUF4348)
4 PHE A 152
PHE A  64
PHE A  71
ALA A  72
None
CXS  A 300 ( 4.9A)
None
EDO  A 307 ( 3.9A)
0.72A 3t3sD-4mjfA:
undetectable
3t3sD-4mjfA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjf HYPOTHETICAL PROTEIN

(Bacteroides
vulgatus)
PF14254
(DUF4348)
4 PHE A 269
PHE A 179
PHE A 186
ALA A 187
None
0.82A 3t3sD-4mjfA:
undetectable
3t3sD-4mjfA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE


(Homo sapiens)
PF00067
(p450)
4 ALA A 113
PHE A 114
ALA A 302
THR A 306
HEM  A 600 ( 2.9A)
3QZ  A 601 ( 4.1A)
3QZ  A 601 (-2.9A)
HEM  A 600 ( 3.2A)
0.51A 3t3sD-4nkyA:
43.6
3t3sD-4nkyA:
31.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN


(Sulfolobus
acidocaldarius)
PF01266
(DAO)
4 PHE A 353
PHE A 350
ALA A 413
ALA A 393
None
0.91A 3t3sD-4opuA:
undetectable
3t3sD-4opuA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio)
PF00067
(p450)
4 ALA A 126
PHE A 127
ALA A 313
THR A 317
HEM  A 600 (-3.6A)
None
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
0.72A 3t3sD-4r1zA:
42.4
3t3sD-4r1zA:
29.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2


(Danio rerio)
PF00067
(p450)
4 ALA A 120
PHE A 121
ALA A 302
THR A 306
AER  A 602 (-3.7A)
None
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
0.55A 3t3sD-4r20A:
41.8
3t3sD-4r20A:
33.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica)
PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C)
4 PHE A  65
PHE A  46
ALA A  44
PHE A  48
None
0.94A 3t3sD-4r4zA:
undetectable
3t3sD-4r4zA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rc6 ALDEHYDE
DECARBONYLASE


(Synechococcus
elongatus)
PF11266
(Ald_deCOase)
4 PHE B  87
ALA B  35
PHE B 117
ALA B 118
None
FE2  B 301 ( 4.3A)
None
None
0.91A 3t3sD-4rc6B:
undetectable
3t3sD-4rc6B:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rph UDP-GALACTOPYRANOSE
MUTASE


(Mycobacterium
tuberculosis)
no annotation 4 ALA B  93
PHE B 102
ASN B 284
ALA B 156
None
GDU  B 402 (-3.9A)
GDU  B 402 (-3.6A)
None
0.90A 3t3sD-4rphB:
undetectable
3t3sD-4rphB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN


(Escherichia
virus T4;
Homo sapiens;
Mus musculus)
PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N)
4 PHE A 261
ALA A 298
ASN A 302
ALA A 124
None
0.80A 3t3sD-4zwjA:
undetectable
3t3sD-4zwjA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2


(Saccharomyces
cerevisiae)
PF00909
(Ammonium_transp)
5 ALA A  88
PHE A  89
PHE A 132
ALA A 133
THR A 136
None
1.26A 3t3sD-5aexA:
undetectable
3t3sD-5aexA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2


(Saccharomyces
cerevisiae)
PF00909
(Ammonium_transp)
5 PHE A 125
PHE A  89
PHE A 132
ALA A 133
THR A 136
None
1.30A 3t3sD-5aexA:
undetectable
3t3sD-5aexA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1u METALLO-BETA-LACTAMA
SE


(Serratia
marcescens)
PF00753
(Lactamase_B)
4 ALA A 241
ASN A 219
ALA A 173
THR A 156
None
0.71A 3t3sD-5b1uA:
undetectable
3t3sD-5b1uA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1


(Homo sapiens)
PF02146
(SIR2)
4 PHE A 273
ALA A 313
PHE A 312
THR A 349
None
0.92A 3t3sD-5btrA:
undetectable
3t3sD-5btrA:
21.30