SIMILAR PATTERNS OF AMINO ACIDS FOR 3T3R_D_9PLD501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjx PROTEIN DISULFIDE
ISOMERASE

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		5 VAL A 175
PHE A 176
PHE A 155
ILE A 169
GLY A 168
 None
 1.20A 3t3rD-1bjxA:
0.0		 3t3rD-1bjxA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 PHE A 297
PHE A 485
PHE A 415
ILE A 476
GLY A 477
 None
None
None
None
LAD  A 601 (-3.4A)
 1.17A 3t3rD-1e1tA:
0.0		 3t3rD-1e1tA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		5 PHE A 289
PHE A 284
PHE A  24
GLY A 274
PHE A 293
 None
None
None
U  B 513 ( 3.3A)
None
 1.22A 3t3rD-1g59A:
0.0		 3t3rD-1g59A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsl HISTIDINE-BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		5 PHE A 231
PHE A 233
PHE A  17
THR A 195
PHE A  29
 None
 1.19A 3t3rD-1hslA:
undetectable		 3t3rD-1hslA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PHE A 225
VAL A 227
PHE A 271
GLY A 134
PHE A 264
 None
 1.21A 3t3rD-1qh4A:
0.0		 3t3rD-1qh4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 PHE B  20
PHE B  29
ILE B 326
GLY B 325
PHE B  28
 None
 1.33A 3t3rD-1tnuB:
0.0		 3t3rD-1tnuB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PHE A 224
VAL A 226
PHE A 270
GLY A 133
PHE A 263
 None
 1.23A 3t3rD-1u6rA:
0.0		 3t3rD-1u6rA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		5 PHE A 131
VAL A 128
PHE A 315
ILE A 115
GLY A 113
 None
 1.23A 3t3rD-1u7gA:
0.7		 3t3rD-1u7gA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrp CREATINE KINASE, M
CHAIN

(Tetronarce
californica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PHE A 225
VAL A 227
PHE A 271
GLY A 134
PHE A 264
 None
 1.36A 3t3rD-1vrpA:
0.0		 3t3rD-1vrpA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		5 PHE A 228
PHE A 180
ASN A 156
ILE A 433
GLY A 434
 None
 1.34A 3t3rD-1w8jA:
undetectable		 3t3rD-1w8jA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 PHE C 104
VAL C 108
PHE C 105
ILE C 135
GLY C 132
 HEM  C 501 ( 4.1A)
HEM  C 502 ( 4.7A)
None
HEM  C 502 (-3.8A)
HEM  C 502 (-3.6A)
 1.27A 3t3rD-1zrtC:
undetectable		 3t3rD-1zrtC:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3q GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CRO  A  66 ( 3.4A)
None
None
 1.15A 3t3rD-2b3qA:
undetectable		 3t3rD-2b3qA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		5 PHE A  54
VAL A 113
PHE A 152
ILE A  36
GLY A  37
 None
 1.02A 3t3rD-2ewyA:
undetectable		 3t3rD-2ewyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq6 SEROLOGICALLY
DEFINED COLON CANCER
ANTIGEN 10

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PHE A 113
VAL A  15
PHE A  54
ILE A 161
PHE A 115
 None
 1.24A 3t3rD-2hq6A:
undetectable		 3t3rD-2hq6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN

(Aequorea
victoria;
Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin)
PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
PIA  A  66 ( 3.9A)
None
None
 1.13A 3t3rD-2jadA:
undetectable		 3t3rD-2jadA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhq URACIL
DNA-GLYCOSYLASE

(Vibrio cholerae) 		PF03167
(UDG) 		5 PHE A  48
PHE A 144
ILE A  11
GLY A  12
PHE A  45
 None
 1.23A 3t3rD-2jhqA:
undetectable		 3t3rD-2jhqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 PHE A1055
PHE A1072
ASN A 966
ILE A1053
THR A 943
 None
 1.36A 3t3rD-2nz9A:
undetectable		 3t3rD-2nz9A:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		9 PHE A 107
PHE A 111
VAL A 117
PHE A 118
PHE A 209
ILE A 300
GLY A 301
THR A 305
PHE A 480
 None
None
HEM  A 500 (-3.7A)
None
None
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
None
 0.74A 3t3rD-2pg6A:
62.6		 3t3rD-2pg6A:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 VAL A 192
PHE A 423
ILE A  56
GLY A  55
PHE A 421
 None
 1.36A 3t3rD-2wyaA:
undetectable		 3t3rD-2wyaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoo PROBABLE NITRITE
REDUCTASE

(Pseudoalteromonas
haloplanktis) 		PF00034
(Cytochrom_C)
PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		5 PHE A  72
PHE A 111
VAL A  91
PHE A 113
ILE A  86
 None
 1.14A 3t3rD-2zooA:
undetectable		 3t3rD-2zooA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.9A)
CR2  A  66 ( 3.7A)
None
None
 1.17A 3t3rD-3ai5A:
undetectable		 3t3rD-3ai5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ako VENUS

(Plant
transformation
vector
pSITEII-4C1) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.6A)
None
None
 1.15A 3t3rD-3akoA:
undetectable		 3t3rD-3akoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A2260
ASN A2269
ILE A2268
GLY A2267
THR A2074
 None
None
None
None
ADP  A2502 (-3.9A)
 1.24A 3t3rD-3cmuA:
undetectable		 3t3rD-3cmuA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqh L-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE ULAE

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		5 PHE A 232
ILE A 186
GLY A 187
THR A 215
PHE A 225
 SO4  A 405 (-4.4A)
None
None
None
None
 1.29A 3t3rD-3cqhA:
undetectable		 3t3rD-3cqhA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czb PUTATIVE
TRANSGLYCOSYLASE

(Caulobacter
vibrioides) 		PF03562
(MltA)
PF06725
(3D) 		5 VAL A 291
PHE A 293
ILE A 219
GLY A 357
THR A 355
 None
 1.37A 3t3rD-3czbA:
undetectable		 3t3rD-3czbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 244
VAL A 192
ILE A 242
GLY A 204
THR A 368
 None
 1.16A 3t3rD-3dh9A:
undetectable		 3t3rD-3dh9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		5 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 0.93A 3t3rD-3e3xA:
undetectable		 3t3rD-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382

(Thermotoga
maritima) 		PF00293
(NUDIX) 		5 PHE A  18
PHE A  21
ASN A 133
GLY A 145
PHE A  35
 None
 1.25A 3t3rD-3e57A:
undetectable		 3t3rD-3e57A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382

(Thermotoga
maritima) 		PF00293
(NUDIX) 		5 PHE A  21
PHE A  32
ASN A 133
GLY A 145
PHE A  35
 None
 1.28A 3t3rD-3e57A:
undetectable		 3t3rD-3e57A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed8 YELLOW FLUORESCENCE
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CRO  A  66 ( 3.9A)
None
None
 1.13A 3t3rD-3ed8A:
undetectable		 3t3rD-3ed8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evp GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A 229
VAL A 270
ASN A 279
ILE A 172
PHE A 166
 None
CRO  A 224 ( 4.9A)
CRO  A 224 ( 3.6A)
None
None
 1.19A 3t3rD-3evpA:
undetectable		 3t3rD-3evpA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 229
VAL A 270
ASN A 279
ILE A 172
PHE A 166
 None
CRO  A 224 ( 4.8A)
CRO  A 224 ( 3.6A)
None
None
 1.19A 3t3rD-3evrA:
undetectable		 3t3rD-3evrA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		5 PHE A 613
PHE A 609
VAL A 492
ILE A 584
GLY A 539
 None
 1.36A 3t3rD-3gq2A:
undetectable		 3t3rD-3gq2A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le2 SERPIN-ZX

(Arabidopsis
thaliana) 		PF00079
(Serpin) 		5 VAL A 372
PHE A 282
ILE A  32
GLY A 384
PHE A 280
 None
 1.21A 3t3rD-3le2A:
undetectable		 3t3rD-3le2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxq UNCHARACTERIZED
PROTEIN VP1736

(Vibrio
parahaemolyticus) 		PF00884
(Sulfatase) 		5 PHE A 392
VAL A 352
PHE A 391
GLY A 335
THR A 328
 None
 1.21A 3t3rD-3lxqA:
undetectable		 3t3rD-3lxqA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 VAL A 287
PHE A 295
PHE A 222
ILE A 224
PHE A 268
 None
 1.26A 3t3rD-3nv3A:
undetectable		 3t3rD-3nv3A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 PHE A 345
VAL A 386
ASN A 395
ILE A 288
PHE A 282
 None
C12  A 340 ( 4.8A)
C12  A 340 ( 3.6A)
None
None
 1.15A 3t3rD-3osqA:
undetectable		 3t3rD-3osqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		5 PHE A 483
VAL A 524
ASN A 533
ILE A 426
PHE A 420
 None
C12  A 478 ( 4.9A)
C12  A 478 ( 3.5A)
None
None
 1.16A 3t3rD-3osrA:
undetectable		 3t3rD-3osrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p28 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A  23
VAL A  64
ASN A  73
ILE A 206
PHE A 200
 None
GYS  A  18 ( 4.7A)
GYS  A  18 ( 3.6A)
None
None
 1.20A 3t3rD-3p28A:
undetectable		 3t3rD-3p28A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxn KINESIN-LIKE PROTEIN
NOD

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 PHE A 293
VAL A 225
PHE A 313
ILE A 256
GLY A 252
 None
 1.34A 3t3rD-3pxnA:
undetectable		 3t3rD-3pxnA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkg PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		5 PHE A  88
PHE A 114
ILE A  60
GLY A  52
PHE A  16
 None
 1.29A 3t3rD-3qkgA:
undetectable		 3t3rD-3qkgA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s48 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H

(Staphylococcus
aureus) 		PF05031
(NEAT) 		5 VAL A 161
PHE A 187
PHE A 114
ILE A 131
PHE A 219
 None
 1.37A 3t3rD-3s48A:
undetectable		 3t3rD-3s48A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 PHE A 169
PHE A 150
ILE A 177
GLY A 178
THR A 153
 None
 1.30A 3t3rD-3swxA:
undetectable		 3t3rD-3swxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz6 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF05031
(NEAT) 		5 PHE A  59
PHE A  76
ILE A 142
GLY A 125
PHE A 146
 None
 1.30A 3t3rD-3sz6A:
undetectable		 3t3rD-3sz6A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 PHE B 214
VAL B 203
ASN B 210
ILE B 166
GLY B 168
 None
 1.36A 3t3rD-3u0jB:
undetectable		 3t3rD-3u0jB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF07361
(Cytochrom_B562) 		5 PHE A 179
VAL A 220
ASN A 229
ILE A  14
PHE A   8
 None
CRO  A 175 ( 4.8A)
CRO  A 175 ( 3.5A)
None
None
 1.19A 3t3rD-3u8pA:
undetectable		 3t3rD-3u8pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 VAL A  50
PHE A  63
ASN A 146
GLY A 156
PHE A  59
 None
 1.31A 3t3rD-3ue1A:
undetectable		 3t3rD-3ue1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 PHE A 490
VAL A 494
PHE A 611
ILE A 558
GLY A 555
 None
 1.33A 3t3rD-3ui7A:
undetectable		 3t3rD-3ui7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		5 PHE A 140
VAL A  47
ILE A  78
THR A  40
PHE A 144
 None
 1.26A 3t3rD-3vocA:
undetectable		 3t3rD-3vocA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 PHE A1071
VAL A1112
ASN A1121
ILE A1014
PHE A1008
 None
 1.15A 3t3rD-4anjA:
undetectable		 3t3rD-4anjA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX

(Aequorea
victoria;
Homo sapiens) 		PF00452
(Bcl-2)
PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  65 ( 4.3A)
None
None
 1.13A 3t3rD-4bduA:
undetectable		 3t3rD-4bduA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 VAL A 125
PHE A 110
ILE A  82
GLY A 106
PHE A 133
 None
 1.36A 3t3rD-4fs7A:
undetectable		 3t3rD-4fs7A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3n DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF03989
(DNA_gyraseA_C) 		5 PHE A 569
PHE A 602
ILE A 608
GLY A 524
THR A 521
 None
 1.35A 3t3rD-4g3nA:
undetectable		 3t3rD-4g3nA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gba DCN1-LIKE PROTEIN 3

(Homo sapiens) 		PF03556
(Cullin_binding) 		5 PHE A 249
PHE A 246
ILE A 253
GLY A 254
PHE A 273
 None
 1.27A 3t3rD-4gbaA:
undetectable		 3t3rD-4gbaA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqb SINGLE-STRANDED
DNA-BINDING PROTEIN
DDRB

(Deinococcus
radiodurans) 		PF12747
(DdrB) 		5 PHE A  56
VAL A  75
PHE A  48
ILE A  61
PHE A 131
 None
 1.23A 3t3rD-4hqbA:
undetectable		 3t3rD-4hqbA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		5 PHE A 205
PHE A 187
PHE A 226
ILE A 249
THR A 240
 None
 1.31A 3t3rD-4i0nA:
undetectable		 3t3rD-4i0nA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrb GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Blattella
germanica) 		PF01353
(GFP)
PF06757
(Ins_allergen_rp) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.8A)
CR2  A  66 ( 3.6A)
None
None
 1.14A 3t3rD-4jrbA:
undetectable		 3t3rD-4jrbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf5 FLUORESCENT PROTEIN
GFP1-9

(synthetic
construct) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 4.1A)
None
None
 1.19A 3t3rD-4kf5A:
undetectable		 3t3rD-4kf5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		5 PHE A 246
PHE A 168
ILE A 287
GLY A 288
PHE A 170
 None
 1.17A 3t3rD-4mq0A:
undetectable		 3t3rD-4mq0A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		5 PHE A 276
PHE A 168
PHE A 170
PHE A 246
ILE A 190
 None
 1.09A 3t3rD-4mq0A:
undetectable		 3t3rD-4mq0A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,

(Aequorea
victoria;
Eimeria
acervulina) 		PF00046
(Homeobox)
PF01353
(GFP) 		5 PHE A 124
VAL A 165
ASN A 174
ILE A  67
PHE A  61
 None
None
CR2  A 118 ( 4.5A)
None
None
 1.13A 3t3rD-4ndkA:
undetectable		 3t3rD-4ndkA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		5 PHE A 335
PHE A 375
PHE A 378
PHE A 331
PHE A 312
 None
 1.36A 3t3rD-4p69A:
undetectable		 3t3rD-4p69A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		5 PHE A 858
VAL A 899
ASN A 908
ILE A 801
PHE A 795
 None
None
CRO  A 853 ( 4.3A)
None
None
 1.18A 3t3rD-4p7hA:
undetectable		 3t3rD-4p7hA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfe GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vicugna pacos) 		PF01353
(GFP)
PF07686
(V-set) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 4.0A)
None
None
 1.21A 3t3rD-4pfeA:
undetectable		 3t3rD-4pfeA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CWC27 HOMOLOG

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PHE A 113
VAL A  15
PHE A  54
ILE A 161
PHE A 115
 None
 1.26A 3t3rD-4r3eA:
undetectable		 3t3rD-4r3eA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Plasmodium
falciparum) 		PF01353
(GFP)
PF02861
(Clp_N) 		5 PHE A 220
VAL A 261
ASN A 270
ILE A 163
PHE A 157
 None
CRO  A 215 ( 4.9A)
CRO  A 215 ( 3.6A)
None
None
 1.19A 3t3rD-4xbiA:
1.5		 3t3rD-4xbiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgy GREEN FLUORESCENT
PROTEIN, MAB LCDR3,
GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vibrio
parahaemolyticus;
synthetic
construct) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.8A)
CRO  A  66 ( 3.6A)
None
None
 1.17A 3t3rD-4xgyA:
undetectable		 3t3rD-4xgyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ym3 GALECTIN-4

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		5 VAL A 287
PHE A 295
PHE A 221
ILE A 223
PHE A 268
 None
 1.31A 3t3rD-4ym3A:
undetectable		 3t3rD-4ym3A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		5 PHE A 319
VAL A 289
PHE A 315
PHE A 133
GLY A 110
 None
MPG  A 404 (-4.1A)
None
None
None
 1.27A 3t3rD-4ymkA:
undetectable		 3t3rD-4ymkA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1

(Aequorea
victoria;
Homo sapiens) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
 1.18A 3t3rD-4z4mA:
undetectable		 3t3rD-4z4mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zf4 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A  21
VAL A  62
ASN A  71
ILE A 207
PHE A 201
 None
4NT  A  15 ( 4.7A)
4NT  A  15 ( 3.6A)
None
None
 1.18A 3t3rD-4zf4A:
undetectable		 3t3rD-4zf4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 5 PHE A 323
VAL A 293
PHE A 319
PHE A 137
GLY A 114
 None
ST9  A 403 (-4.8A)
None
None
None
 1.20A 3t3rD-4zyoA:
undetectable		 3t3rD-4zyoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqk ICP27

(Human
alphaherpesvirus
1) 		PF05459
(Herpes_UL69) 		5 VAL A 429
PHE A 430
ILE A 475
GLY A 471
PHE A 349
 None
 1.15A 3t3rD-5bqkA:
undetectable		 3t3rD-5bqkA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		5 PHE A 477
PHE A 473
ASN A 515
ILE A 493
GLY A 519
 None
 1.20A 3t3rD-5d3oA:
undetectable		 3t3rD-5d3oA:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B

(Neotoma lepida) 		PF00067
(p450) 		5 PHE A 297
VAL A 114
PHE A 115
PHE A 206
GLY A 299
 None
HEM  A 501 (-3.5A)
None
None
HEM  A 501 (-3.5A)
 1.26A 3t3rD-5e0eA:
51.6		 3t3rD-5e0eA:
55.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D

(Aequorea
victoria;
Streptococcus
pyogenes) 		PF01353
(GFP)
PF13930
(Endonuclea_NS_2) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.7A)
None
None
 1.14A 3t3rD-5fguA:
undetectable		 3t3rD-5fguA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkq ALYGC MUTANT - R241A

(Paraglaciecola
chathamensis) 		PF14592
(Chondroitinas_B) 		5 PHE A 231
PHE A 207
ASN A 229
ILE A 226
THR A 200
 None
 1.34A 3t3rD-5gkqA:
undetectable		 3t3rD-5gkqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 PHE A 254
PHE A 196
ASN A 172
ILE A 459
GLY A 460
 None
 0.84A 3t3rD-5h53A:
undetectable		 3t3rD-5h53A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		5 PHE A 226
ASN A 154
ILE A 431
GLY A 432
THR A 222
 None
 1.27A 3t3rD-5hmpA:
undetectable		 3t3rD-5hmpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF12008
(EcoR124_C) 		5 PHE A  77
VAL A 118
ASN A 127
ILE A  20
PHE A  14
 None
GYS  A  72 ( 4.8A)
GYS  A  72 ( 3.8A)
None
None
 1.13A 3t3rD-5j3nA:
undetectable		 3t3rD-5j3nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii) 		no annotation 5 PHE A  47
VAL A 124
PHE A 106
ILE A 273
GLY A 274
 None
 1.25A 3t3rD-5j4rA:
undetectable		 3t3rD-5j4rA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnq PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

([Clostridium]
bolteae) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		5 VAL A 241
PHE A 240
ILE A 257
GLY A 258
THR A 311
 None
 1.26A 3t3rD-5jnqA:
undetectable		 3t3rD-5jnqA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00290
(Trp_syntA)
PF00291
(PALP) 		5 PHE A 138
PHE A 107
VAL B 283
PHE A 103
GLY B  16
 None
 1.29A 3t3rD-5kinA:
undetectable		 3t3rD-5kinA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER

(Aequorea
victoria;
Mus musculus) 		PF00452
(Bcl-2)
PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 4.1A)
None
None
 1.13A 3t3rD-5ktgA:
undetectable		 3t3rD-5ktgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 PHE A 457
VAL A 455
PHE A 468
PHE A 248
ILE A 432
 None
 1.36A 3t3rD-5lcwA:
undetectable		 3t3rD-5lcwA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mse GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		no annotation 5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 3.7A)
None
None
 1.17A 3t3rD-5mseA:
undetectable		 3t3rD-5mseA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 5 PHE A 560
PHE A 722
ILE A 690
GLY A 691
PHE A 784
 None
 0.93A 3t3rD-5n2gA:
0.5		 3t3rD-5n2gA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7h CRISPR-ASSOCIATED
PROTEIN, CSY4 FAMILY

(Shewanella
putrefaciens) 		PF09618
(Cas_Csy4) 		5 PHE B 155
VAL B  97
PHE B 157
PHE B  25
GLY B 173
 None
 1.01A 3t3rD-5o7hB:
undetectable		 3t3rD-5o7hB:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oq3 CWP19

(Clostridioides
difficile) 		no annotation 5 PHE A 194
VAL A 227
PHE A 198
ILE A 176
PHE A 247
 None
 1.34A 3t3rD-5oq3A:
undetectable		 3t3rD-5oq3A:
21.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 PHE A 107
PHE A 108
PHE A 202
ASN A 242
ILE A 241
 None
9ZJ  A 502 (-4.4A)
None
None
None
 1.34A 3t3rD-5wbgA:
55.6		 3t3rD-5wbgA:
66.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi2 CDNA FLJ56409,
HIGHLY SIMILAR TO
SERINE/THREONINE-PRO
TEIN KINASE CHK1 (EC
2.7.11.1)

(Homo sapiens) 		no annotation 5 PHE A 441
PHE A 426
PHE A 451
PHE A 380
ILE A 458
 None
 1.29A 3t3rD-5wi2A:
undetectable		 3t3rD-5wi2A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg5 MITSUBA-1

(synthetic
construct) 		PF14200
(RicinB_lectin_2) 		5 PHE A  44
VAL A  63
PHE A 140
ILE A   6
PHE A  92
 None
 1.34A 3t3rD-5xg5A:
undetectable		 3t3rD-5xg5A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg5 MITSUBA-1

(synthetic
construct) 		PF14200
(RicinB_lectin_2) 		5 PHE A 140
VAL A  15
PHE A  92
ILE A 102
PHE A  44
 None
 1.31A 3t3rD-5xg5A:
undetectable		 3t3rD-5xg5A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 5 PHE A 843
VAL A 923
ILE A 830
GLY A 860
THR A 882
 None
 1.27A 3t3rD-5xyaA:
undetectable		 3t3rD-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yba PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Trichomonas
vaginalis) 		no annotation 5 PHE A  23
PHE A 137
PHE A   9
GLY A  72
THR A  59
 None
 1.30A 3t3rD-5ybaA:
undetectable		 3t3rD-5ybaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anz UNCHARACTERIZED
PROTEIN

(Neisseria
gonorrhoeae) 		no annotation 5 PHE A  12
PHE A  36
ILE A  22
GLY A   9
PHE A  42
 None
 1.19A 3t3rD-6anzA:
undetectable		 3t3rD-6anzA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 PHE A 113
ASN A 109
ILE A  84
GLY A 107
THR A  87
 None
 1.19A 3t3rD-6aphA:
0.0		 3t3rD-6aphA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3y DENN
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		no annotation 5 PHE A 774
PHE A 771
PHE A 735
ILE A 744
THR A 914
 None
 1.21A 3t3rD-6b3yA:
undetectable		 3t3rD-6b3yA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7t GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		no annotation 5 PHE A 101
VAL A 142
ASN A 151
ILE A  44
PHE A  38
 None
GYS  A  96 ( 4.9A)
GYS  A  96 ( 3.6A)
None
None
 1.16A 3t3rD-6b7tA:
undetectable		 3t3rD-6b7tA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 5 PHE A 111
ASN A 107
ILE A  82
GLY A 105
THR A  85
 None
 1.19A 3t3rD-6gbnA:
0.7		 3t3rD-6gbnA:
undetectable