SIMILAR PATTERNS OF AMINO ACIDS FOR 3T3R_C_9PLC501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 PHE A 603
PHE A 583
ILE A 601
THR A 538
PHE A 574
 None
 1.24A 3t3rC-1ciyA:
0.0		 3t3rC-1ciyA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 PHE A 603
PHE A 583
ILE A 601
THR A 538
PHE A 576
 None
 1.43A 3t3rC-1ciyA:
0.0		 3t3rC-1ciyA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 PHE A 128
ASN A 143
ILE A 107
THR A 147
PHE A 152
 None
 1.27A 3t3rC-1czfA:
0.0		 3t3rC-1czfA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		5 PHE A 289
PHE A 284
PHE A  24
GLY A 274
PHE A 293
 None
None
None
U  B 513 ( 3.3A)
None
 1.19A 3t3rC-1g59A:
0.0		 3t3rC-1g59A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PHE A 225
VAL A 227
PHE A 271
GLY A 134
PHE A 264
 None
 1.20A 3t3rC-1qh4A:
0.0		 3t3rC-1qh4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PHE A 224
VAL A 226
PHE A 270
GLY A 133
PHE A 263
 None
 1.23A 3t3rC-1u6rA:
0.0		 3t3rC-1u6rA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		5 PHE A 131
VAL A 128
PHE A 315
ILE A 115
GLY A 113
 None
 1.32A 3t3rC-1u7gA:
0.0		 3t3rC-1u7gA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhg OVALBUMIN

(Gallus gallus) 		PF00079
(Serpin) 		5 VAL A 383
PHE A  15
ASN A  26
ILE A  27
GLY A 380
 None
 1.27A 3t3rC-1uhgA:
0.0		 3t3rC-1uhgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v15 COLICIN E9

(Escherichia
coli) 		no annotation 5 PHE A  50
PHE A  53
VAL A  57
ILE A 119
THR A 122
 None
 1.39A 3t3rC-1v15A:
undetectable		 3t3rC-1v15A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrp CREATINE KINASE, M
CHAIN

(Tetronarce
californica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PHE A 225
VAL A 227
PHE A 271
GLY A 134
PHE A 264
 None
 1.34A 3t3rC-1vrpA:
0.0		 3t3rC-1vrpA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		5 PHE A 116
PHE A 166
ILE A 179
GLY A 176
THR A 173
 None
 1.36A 3t3rC-2a9vA:
undetectable		 3t3rC-2a9vA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3q GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CRO  A  66 ( 3.4A)
None
None
 1.20A 3t3rC-2b3qA:
undetectable		 3t3rC-2b3qA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dup VESICULAR
INTEGRAL-MEMBRANE
PROTEIN VIP36

(Canis lupus) 		PF03388
(Lectin_leg-like) 		5 PHE A 118
PHE A 206
ILE A 133
GLY A 132
THR A 163
 None
 1.23A 3t3rC-2dupA:
undetectable		 3t3rC-2dupA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e50 PROTEIN SET

(Homo sapiens) 		PF00956
(NAP) 		5 PHE A  86
PHE A 126
ILE A 208
GLY A 205
PHE A 189
 None
 1.34A 3t3rC-2e50A:
undetectable		 3t3rC-2e50A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		5 PHE A 503
PHE A 293
PHE A 328
ILE A 506
PHE A 332
 None
None
None
None
HEM  A 605 (-4.4A)
 1.41A 3t3rC-2gjmA:
undetectable		 3t3rC-2gjmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq6 SEROLOGICALLY
DEFINED COLON CANCER
ANTIGEN 10

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PHE A 113
VAL A  15
PHE A  54
ILE A 161
PHE A 115
 None
 1.21A 3t3rC-2hq6A:
undetectable		 3t3rC-2hq6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 PHE A  78
VAL A  33
ILE A  59
GLY A  26
THR A  24
 None
 1.37A 3t3rC-2i1jA:
undetectable		 3t3rC-2i1jA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN

(Aequorea
victoria;
Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin)
PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
PIA  A  66 ( 3.9A)
None
None
 1.20A 3t3rC-2jadA:
undetectable		 3t3rC-2jadA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhq URACIL
DNA-GLYCOSYLASE

(Vibrio cholerae) 		PF03167
(UDG) 		5 PHE A  48
PHE A 144
ILE A  11
GLY A  12
PHE A  45
 None
 1.23A 3t3rC-2jhqA:
undetectable		 3t3rC-2jhqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfu RV1827 PTHR 22

(Mycobacterium
tuberculosis) 		PF00498
(FHA) 		5 PHE A  70
VAL A  60
ILE A 139
GLY A 140
THR A  93
 None
 1.37A 3t3rC-2kfuA:
undetectable		 3t3rC-2kfuA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 PHE A 155
PHE A 650
ILE A 361
GLY A 367
PHE A 151
 None
 1.42A 3t3rC-2nyaA:
undetectable		 3t3rC-2nyaA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 PHE A1055
PHE A1072
ASN A 966
ILE A1053
THR A 943
 None
 1.32A 3t3rC-2nz9A:
undetectable		 3t3rC-2nz9A:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		8 PHE A 107
PHE A 111
VAL A 117
PHE A 209
ILE A 300
GLY A 301
THR A 305
PHE A 480
 None
None
HEM  A 500 (-3.7A)
None
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
None
 0.50A 3t3rC-2pg6A:
63.9		 3t3rC-2pg6A:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 PHE A 431
PHE A 407
ASN A 456
ILE A 438
PHE A 385
 None
 1.44A 3t3rC-2uvfA:
undetectable		 3t3rC-2uvfA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Homo sapiens) 		PF04869
(Uso1_p115_head) 		5 PHE A 613
PHE A 609
VAL A 492
ILE A 584
GLY A 539
 None
 1.36A 3t3rC-2w3cA:
undetectable		 3t3rC-2w3cA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbv FIBER PROTEIN

(Canine
mastadenovirus
A) 		no annotation 5 PHE A 418
PHE A 528
ILE A 383
THR A 530
PHE A 519
 None
 1.35A 3t3rC-2wbvA:
undetectable		 3t3rC-2wbvA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 VAL A 192
PHE A 423
ILE A  56
GLY A  55
PHE A 421
 None
 1.34A 3t3rC-2wyaA:
undetectable		 3t3rC-2wyaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		5 PHE A 225
ASN A 300
ILE A 302
GLY A 303
PHE A 312
 None
 1.44A 3t3rC-2xa2A:
undetectable		 3t3rC-2xa2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.9A)
CR2  A  66 ( 3.7A)
None
None
 1.22A 3t3rC-3ai5A:
undetectable		 3t3rC-3ai5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ako VENUS

(Plant
transformation
vector
pSITEII-4C1) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.6A)
None
None
 1.20A 3t3rC-3akoA:
undetectable		 3t3rC-3akoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7l LIN1944 PROTEIN

(Listeria
innocua) 		PF13561
(adh_short_C2) 		5 PHE A 171
VAL A 156
ASN A 155
GLY A 112
PHE A  68
 None
 1.20A 3t3rC-3d7lA:
undetectable		 3t3rC-3d7lA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 244
VAL A 192
ILE A 242
GLY A 204
THR A 368
 None
 1.17A 3t3rC-3dh9A:
undetectable		 3t3rC-3dh9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		5 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 0.93A 3t3rC-3e3xA:
undetectable		 3t3rC-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382

(Thermotoga
maritima) 		PF00293
(NUDIX) 		5 PHE A  18
PHE A  21
ASN A 133
GLY A 145
PHE A  35
 None
 1.30A 3t3rC-3e57A:
undetectable		 3t3rC-3e57A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed8 YELLOW FLUORESCENCE
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CRO  A  66 ( 3.9A)
None
None
 1.18A 3t3rC-3ed8A:
undetectable		 3t3rC-3ed8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evp GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A 229
VAL A 270
ASN A 279
ILE A 172
PHE A 166
 None
CRO  A 224 ( 4.9A)
CRO  A 224 ( 3.6A)
None
None
 1.25A 3t3rC-3evpA:
undetectable		 3t3rC-3evpA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 229
VAL A 270
ASN A 279
ILE A 172
PHE A 166
 None
CRO  A 224 ( 4.8A)
CRO  A 224 ( 3.6A)
None
None
 1.23A 3t3rC-3evrA:
undetectable		 3t3rC-3evrA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		5 PHE A 613
PHE A 609
VAL A 492
ILE A 584
GLY A 539
 None
 1.29A 3t3rC-3gq2A:
undetectable		 3t3rC-3gq2A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		5 PHE A 131
PHE A 132
ASN A 116
ILE A  43
THR A  82
 None
 1.43A 3t3rC-3h0lA:
undetectable		 3t3rC-3h0lA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		5 PHE M   8
PHE M  96
ILE M 270
GLY M 268
PHE M   4
 None
 1.37A 3t3rC-3i04M:
undetectable		 3t3rC-3i04M:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le2 SERPIN-ZX

(Arabidopsis
thaliana) 		PF00079
(Serpin) 		5 VAL A 372
PHE A 282
ILE A  32
GLY A 384
PHE A 280
 None
 1.33A 3t3rC-3le2A:
undetectable		 3t3rC-3le2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 PHE A 345
VAL A 386
ASN A 395
ILE A 288
PHE A 282
 None
C12  A 340 ( 4.8A)
C12  A 340 ( 3.6A)
None
None
 1.21A 3t3rC-3osqA:
undetectable		 3t3rC-3osqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		5 PHE A 483
VAL A 524
ASN A 533
ILE A 426
PHE A 420
 None
C12  A 478 ( 4.9A)
C12  A 478 ( 3.5A)
None
None
 1.22A 3t3rC-3osrA:
undetectable		 3t3rC-3osrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p28 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A  23
VAL A  64
ASN A  73
ILE A 206
PHE A 200
 None
GYS  A  18 ( 4.7A)
GYS  A  18 ( 3.6A)
None
None
 1.25A 3t3rC-3p28A:
undetectable		 3t3rC-3p28A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxn KINESIN-LIKE PROTEIN
NOD

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		5 PHE A 293
VAL A 225
PHE A 313
ILE A 256
GLY A 252
 None
 1.31A 3t3rC-3pxnA:
undetectable		 3t3rC-3pxnA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		5 PHE A 268
PHE A 239
PHE A 286
THR A 308
PHE A 294
 None
 1.39A 3t3rC-3t6qA:
undetectable		 3t3rC-3t6qA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 PHE A 122
PHE A 180
ILE A 193
GLY A 190
THR A 187
 None
 1.40A 3t3rC-3tqiA:
undetectable		 3t3rC-3tqiA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 PHE B 214
VAL B 203
ASN B 210
ILE B 166
GLY B 168
 None
 1.39A 3t3rC-3u0jB:
undetectable		 3t3rC-3u0jB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF07361
(Cytochrom_B562) 		5 PHE A 179
VAL A 220
ASN A 229
ILE A  14
PHE A   8
 None
CRO  A 175 ( 4.8A)
CRO  A 175 ( 3.5A)
None
None
 1.23A 3t3rC-3u8pA:
undetectable		 3t3rC-3u8pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 VAL A  50
PHE A  63
ASN A 146
GLY A 156
PHE A  59
 None
 1.35A 3t3rC-3ue1A:
undetectable		 3t3rC-3ue1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 PHE A 490
VAL A 494
PHE A 611
ILE A 558
GLY A 555
 None
 1.34A 3t3rC-3ui7A:
undetectable		 3t3rC-3ui7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 PHE A  84
VAL A  73
PHE A 317
ILE A  79
GLY A  76
 None
 1.42A 3t3rC-3vr5A:
undetectable		 3t3rC-3vr5A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2x EXODEOXYRIBONUCLEASE

(Methanothermobacter
thermautotrophicus) 		PF03372
(Exo_endo_phos) 		5 PHE A 132
PHE A  86
PHE A 152
ILE A 110
PHE A 184
 None
 1.41A 3t3rC-3w2xA:
undetectable		 3t3rC-3w2xA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhp CALCIUM-BINDING
PROTEIN 39-LIKE

(Homo sapiens) 		PF08569
(Mo25) 		5 PHE A 165
VAL A 198
PHE A 169
ILE A 209
PHE A 187
 None
 1.37A 3t3rC-3zhpA:
undetectable		 3t3rC-3zhpA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 PHE A1071
VAL A1112
ASN A1121
ILE A1014
PHE A1008
 None
 1.22A 3t3rC-4anjA:
undetectable		 3t3rC-4anjA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX

(Aequorea
victoria;
Homo sapiens) 		PF00452
(Bcl-2)
PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  65 ( 4.3A)
None
None
 1.18A 3t3rC-4bduA:
undetectable		 3t3rC-4bduA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 PHE A 915
PHE A 916
VAL A 910
ILE A 847
GLY A 844
 None
 1.44A 3t3rC-4crsA:
undetectable		 3t3rC-4crsA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 VAL A 125
PHE A 110
ILE A  82
GLY A 106
PHE A 133
 None
 1.40A 3t3rC-4fs7A:
undetectable		 3t3rC-4fs7A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3n DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF03989
(DNA_gyraseA_C) 		5 PHE A 569
PHE A 602
ILE A 608
GLY A 524
THR A 521
 None
 1.43A 3t3rC-4g3nA:
undetectable		 3t3rC-4g3nA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrb GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Blattella
germanica) 		PF01353
(GFP)
PF06757
(Ins_allergen_rp) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.8A)
CR2  A  66 ( 3.6A)
None
None
 1.19A 3t3rC-4jrbA:
undetectable		 3t3rC-4jrbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf5 FLUORESCENT PROTEIN
GFP1-9

(synthetic
construct) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 4.1A)
None
None
 1.25A 3t3rC-4kf5A:
undetectable		 3t3rC-4kf5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		5 PHE A 192
VAL A 273
ILE A 287
GLY A 288
PHE A 170
 None
 1.41A 3t3rC-4mq0A:
undetectable		 3t3rC-4mq0A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,

(Aequorea
victoria;
Eimeria
acervulina) 		PF00046
(Homeobox)
PF01353
(GFP) 		5 PHE A 124
VAL A 165
ASN A 174
ILE A  67
PHE A  61
 None
None
CR2  A 118 ( 4.5A)
None
None
 1.18A 3t3rC-4ndkA:
undetectable		 3t3rC-4ndkA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		5 PHE A 858
VAL A 899
ASN A 908
ILE A 801
PHE A 795
 None
None
CRO  A 853 ( 4.3A)
None
None
 1.23A 3t3rC-4p7hA:
undetectable		 3t3rC-4p7hA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfe GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vicugna pacos) 		PF01353
(GFP)
PF07686
(V-set) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 4.0A)
None
None
 1.27A 3t3rC-4pfeA:
undetectable		 3t3rC-4pfeA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 PHE A1003
PHE A1006
VAL A 565
PHE A 984
ILE A1157
 None
 1.37A 3t3rC-4ptfA:
undetectable		 3t3rC-4ptfA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CWC27 HOMOLOG

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PHE A 113
VAL A  15
PHE A  54
ILE A 161
PHE A 115
 None
 1.24A 3t3rC-4r3eA:
undetectable		 3t3rC-4r3eA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbd BSHC

(Bacillus
subtilis) 		PF10079
(BshC) 		5 PHE A 520
PHE A 519
ILE A 508
THR A 102
PHE A 222
 None
 1.43A 3t3rC-4wbdA:
undetectable		 3t3rC-4wbdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli) 		PF06007
(PhnJ) 		5 VAL D 175
PHE D 123
ASN D 193
ILE D 188
PHE D 205
 None
 1.34A 3t3rC-4xb6D:
undetectable		 3t3rC-4xb6D:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Plasmodium
falciparum) 		PF01353
(GFP)
PF02861
(Clp_N) 		5 PHE A 220
VAL A 261
ASN A 270
ILE A 163
PHE A 157
 None
CRO  A 215 ( 4.9A)
CRO  A 215 ( 3.6A)
None
None
 1.24A 3t3rC-4xbiA:
undetectable		 3t3rC-4xbiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgy GREEN FLUORESCENT
PROTEIN, MAB LCDR3,
GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vibrio
parahaemolyticus;
synthetic
construct) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.8A)
CRO  A  66 ( 3.6A)
None
None
 1.22A 3t3rC-4xgyA:
undetectable		 3t3rC-4xgyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydj HEAVY CHAIN OF
ANTIBODY 44-VRC13.01
LIGHT CHAIN OF
ANTIBODY 44-VRC13.01

(Homo sapiens) 		no annotation 5 PHE L  98
PHE H  35
ILE H  35
GLY H  49
THR H  58
 None
 1.28A 3t3rC-4ydjL:
undetectable		 3t3rC-4ydjL:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1

(Aequorea
victoria;
Homo sapiens) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
 1.22A 3t3rC-4z4mA:
undetectable		 3t3rC-4z4mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zf4 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A  21
VAL A  62
ASN A  71
ILE A 207
PHE A 201
 None
4NT  A  15 ( 4.7A)
4NT  A  15 ( 3.6A)
None
None
 1.23A 3t3rC-4zf4A:
undetectable		 3t3rC-4zf4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE

(Methanothermobacter
thermautotrophicus) 		PF09414
(RNA_ligase) 		5 PHE A 172
VAL A 174
PHE A 140
ILE A 105
PHE A 139
 None
 1.43A 3t3rC-5d1pA:
undetectable		 3t3rC-5d1pA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 PHE A 417
PHE A 403
ASN A 472
THR A 401
PHE A 371
 None
None
FAD  A 603 (-3.7A)
None
None
 1.28A 3t3rC-5d79A:
undetectable		 3t3rC-5d79A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D

(Aequorea
victoria;
Streptococcus
pyogenes) 		PF01353
(GFP)
PF13930
(Endonuclea_NS_2) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.7A)
None
None
 1.19A 3t3rC-5fguA:
undetectable		 3t3rC-5fguA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 5 PHE A 480
VAL A 473
ILE A 491
GLY A 493
PHE A 525
 None
 1.43A 3t3rC-5h4eA:
undetectable		 3t3rC-5h4eA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 PHE A 254
PHE A 196
ASN A 172
ILE A 459
GLY A 460
 None
 0.87A 3t3rC-5h53A:
undetectable		 3t3rC-5h53A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		5 PHE A  14
VAL B1173
PHE A  22
ILE A  40
THR A  27
 None
 1.37A 3t3rC-5h67A:
undetectable		 3t3rC-5h67A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		5 VAL A 394
PHE A  43
ASN A  54
ILE A  55
GLY A 391
 None
 1.34A 3t3rC-5hgcA:
undetectable		 3t3rC-5hgcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		5 PHE A 226
ASN A 154
ILE A 431
GLY A 432
THR A 222
 None
 1.29A 3t3rC-5hmpA:
undetectable		 3t3rC-5hmpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF12008
(EcoR124_C) 		5 PHE A  77
VAL A 118
ASN A 127
ILE A  20
PHE A  14
 None
GYS  A  72 ( 4.8A)
GYS  A  72 ( 3.8A)
None
None
 1.18A 3t3rC-5j3nA:
undetectable		 3t3rC-5j3nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii) 		no annotation 5 PHE A  47
VAL A 124
PHE A 106
ILE A 273
GLY A 274
 None
 1.26A 3t3rC-5j4rA:
undetectable		 3t3rC-5j4rA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER

(Aequorea
victoria;
Mus musculus) 		PF00452
(Bcl-2)
PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 4.1A)
None
None
 1.17A 3t3rC-5ktgA:
undetectable		 3t3rC-5ktgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5moy BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 PHE A1055
PHE A1072
ASN A 966
ILE A1053
THR A 943
 None
 1.31A 3t3rC-5moyA:
undetectable		 3t3rC-5moyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mse GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		no annotation 5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 3.7A)
None
None
 1.21A 3t3rC-5mseA:
undetectable		 3t3rC-5mseA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 5 PHE A 560
PHE A 722
ILE A 690
GLY A 691
PHE A 784
 None
 0.94A 3t3rC-5n2gA:
undetectable		 3t3rC-5n2gA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqp CONDENSIN COMPLEX
SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 5 PHE A 114
PHE A 111
PHE A  58
ILE A  86
PHE A  54
 None
 1.13A 3t3rC-5oqpA:
undetectable		 3t3rC-5oqpA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 5 PHE B  33
PHE B 317
GLY B 602
THR B 313
PHE B 328
 None
 1.38A 3t3rC-5swiB:
undetectable		 3t3rC-5swiB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpc BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 PHE A1055
PHE A1072
ASN A 966
ILE A1053
THR A 943
 None
 1.33A 3t3rC-5tpcA:
undetectable		 3t3rC-5tpcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqj U6 SNRNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF09749
(HVSL) 		5 PHE A 204
VAL A 134
PHE A 289
ILE A 276
PHE A 167
 None
 1.16A 3t3rC-5uqjA:
undetectable		 3t3rC-5uqjA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg5 MITSUBA-1

(synthetic
construct) 		PF14200
(RicinB_lectin_2) 		5 PHE A  44
VAL A  63
PHE A 140
ILE A   6
PHE A  92
 None
 1.30A 3t3rC-5xg5A:
undetectable		 3t3rC-5xg5A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg5 MITSUBA-1

(synthetic
construct) 		PF14200
(RicinB_lectin_2) 		5 PHE A  92
VAL A 111
PHE A  44
ILE A  54
PHE A 140
 None
 1.29A 3t3rC-5xg5A:
undetectable		 3t3rC-5xg5A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg5 MITSUBA-1

(synthetic
construct) 		PF14200
(RicinB_lectin_2) 		5 PHE A 140
VAL A  15
PHE A  92
ILE A 102
PHE A  44
 None
 1.28A 3t3rC-5xg5A:
undetectable		 3t3rC-5xg5A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 PHE A  10
ILE A   8
GLY A  38
THR A  42
PHE A  83
 None
 1.26A 3t3rC-5xsqA:
undetectable		 3t3rC-5xsqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 5 PHE A 517
PHE A 721
ASN A 741
ILE A 740
PHE A 526
 None
 1.43A 3t3rC-5xwyA:
undetectable		 3t3rC-5xwyA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 5 PHE A 843
VAL A 923
ILE A 830
GLY A 860
THR A 882
 None
 1.31A 3t3rC-5xyaA:
undetectable		 3t3rC-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anz UNCHARACTERIZED
PROTEIN

(Neisseria
gonorrhoeae) 		no annotation 5 PHE A  12
PHE A  36
ILE A  22
GLY A   9
PHE A  42
 None
 1.08A 3t3rC-6anzA:
undetectable		 3t3rC-6anzA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7t GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		no annotation 5 PHE A 101
VAL A 142
ASN A 151
ILE A  44
PHE A  38
 None
GYS  A  96 ( 4.9A)
GYS  A  96 ( 3.6A)
None
None
 1.22A 3t3rC-6b7tA:
undetectable		 3t3rC-6b7tA:
11.84