SIMILAR PATTERNS OF AMINO ACIDS FOR 3T3R_B_9PLB501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		5 PHE A 289
PHE A 284
PHE A  24
GLY A 274
PHE A 293
 None
None
None
U  B 513 ( 3.3A)
None
 1.18A 3t3rB-1g59A:
0.0		 3t3rB-1g59A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsl HISTIDINE-BINDING
PROTEIN

(Escherichia
coli) 		PF00497
(SBP_bac_3) 		5 PHE A 231
PHE A 233
PHE A  17
THR A 195
PHE A  29
 None
 1.27A 3t3rB-1hslA:
0.0		 3t3rB-1hslA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 PHE A 208
ASN A 434
GLY A 441
THR A 214
PHE A 825
 None
 1.28A 3t3rB-1kqfA:
0.0		 3t3rB-1kqfA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PHE A 225
VAL A 227
PHE A 271
GLY A 134
PHE A 264
 None
 1.18A 3t3rB-1qh4A:
0.0		 3t3rB-1qh4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru3 ACETYL-COA SYNTHASE

(Carboxydothermus
hydrogenoformans) 		PF03598
(CdhC) 		5 PHE A  11
PHE A  99
ILE A 273
GLY A 271
PHE A   7
 None
 1.38A 3t3rB-1ru3A:
0.0		 3t3rB-1ru3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PHE A 224
VAL A 226
PHE A 270
GLY A 133
PHE A 263
 None
 1.20A 3t3rB-1u6rA:
0.0		 3t3rB-1u6rA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		5 PHE A 131
VAL A 128
PHE A 315
ILE A 115
GLY A 113
 None
 1.25A 3t3rB-1u7gA:
1.1		 3t3rB-1u7gA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhg OVALBUMIN

(Gallus gallus) 		PF00079
(Serpin) 		5 VAL A 383
PHE A  15
ASN A  26
ILE A  27
GLY A 380
 None
 1.30A 3t3rB-1uhgA:
0.0		 3t3rB-1uhgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v15 COLICIN E9

(Escherichia
coli) 		no annotation 5 PHE A  50
PHE A  53
VAL A  57
ILE A 119
THR A 122
 None
 1.36A 3t3rB-1v15A:
undetectable		 3t3rB-1v15A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrp CREATINE KINASE, M
CHAIN

(Tetronarce
californica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 PHE A 225
VAL A 227
PHE A 271
GLY A 134
PHE A 264
 None
 1.34A 3t3rB-1vrpA:
undetectable		 3t3rB-1vrpA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqa GLYOXALASE/BLEOMYCIN
RESISTANCE PROTEIN

(Bacillus cereus) 		PF00903
(Glyoxalase) 		5 PHE A  98
VAL A  87
ASN A  77
ILE A  76
PHE A  19
 None
None
None
P6G  A 502 ( 4.9A)
None
 1.14A 3t3rB-1xqaA:
undetectable		 3t3rB-1xqaA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		5 PHE A 116
PHE A 166
ILE A 179
GLY A 176
THR A 173
 None
 1.34A 3t3rB-2a9vA:
undetectable		 3t3rB-2a9vA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3q GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CRO  A  66 ( 3.4A)
None
None
 1.16A 3t3rB-2b3qA:
undetectable		 3t3rB-2b3qA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e50 PROTEIN SET

(Homo sapiens) 		PF00956
(NAP) 		5 PHE A  86
PHE A 126
ILE A 208
GLY A 205
PHE A 189
 None
 1.32A 3t3rB-2e50A:
undetectable		 3t3rB-2e50A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hq6 SEROLOGICALLY
DEFINED COLON CANCER
ANTIGEN 10

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 PHE A 113
VAL A  15
PHE A  54
ILE A 161
PHE A 115
 None
 1.22A 3t3rB-2hq6A:
undetectable		 3t3rB-2hq6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN

(Aequorea
victoria;
Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin)
PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
PIA  A  66 ( 3.9A)
None
None
 1.17A 3t3rB-2jadA:
undetectable		 3t3rB-2jadA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jhq URACIL
DNA-GLYCOSYLASE

(Vibrio cholerae) 		PF03167
(UDG) 		5 PHE A  48
PHE A 144
ILE A  11
GLY A  12
PHE A  45
 None
 1.24A 3t3rB-2jhqA:
undetectable		 3t3rB-2jhqA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfu RV1827 PTHR 22

(Mycobacterium
tuberculosis) 		PF00498
(FHA) 		5 PHE A  70
VAL A  60
ILE A 139
GLY A 140
THR A  93
 None
 1.33A 3t3rB-2kfuA:
undetectable		 3t3rB-2kfuA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 PHE A1055
PHE A1072
ASN A 966
ILE A1053
THR A 943
 None
 1.30A 3t3rB-2nz9A:
undetectable		 3t3rB-2nz9A:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		8 PHE A 107
PHE A 111
VAL A 117
PHE A 209
ILE A 300
GLY A 301
THR A 305
PHE A 480
 None
None
HEM  A 500 (-3.7A)
None
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
None
 0.60A 3t3rB-2pg6A:
64.3		 3t3rB-2pg6A:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbv FIBER PROTEIN

(Canine
mastadenovirus
A) 		no annotation 5 PHE A 418
PHE A 528
ILE A 383
THR A 530
PHE A 519
 None
 1.37A 3t3rB-2wbvA:
undetectable		 3t3rB-2wbvA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 VAL A 192
PHE A 423
ILE A  56
GLY A  55
PHE A 421
 None
 1.28A 3t3rB-2wyaA:
undetectable		 3t3rB-2wyaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.9A)
CR2  A  66 ( 3.7A)
None
None
 1.19A 3t3rB-3ai5A:
undetectable		 3t3rB-3ai5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ako VENUS

(Plant
transformation
vector
pSITEII-4C1) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.6A)
None
None
 1.17A 3t3rB-3akoA:
undetectable		 3t3rB-3akoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmt PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A3260
ASN A3269
ILE A3268
GLY A3267
THR A3074
 None
None
None
None
ADP  A3502 (-3.7A)
 1.17A 3t3rB-3cmtA:
undetectable		 3t3rB-3cmtA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A 260
ASN A 269
ILE A 268
GLY A 267
THR A  74
 None
None
None
None
ADP  A 502 (-3.9A)
 1.22A 3t3rB-3cmuA:
undetectable		 3t3rB-3cmuA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A1260
ASN A1269
ILE A1268
GLY A1267
THR A1074
 None
None
None
None
ADP  A1502 (-3.5A)
 1.23A 3t3rB-3cmuA:
undetectable		 3t3rB-3cmuA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A2260
ASN A2269
ILE A2268
GLY A2267
THR A2074
 None
None
None
None
ADP  A2502 (-3.9A)
 1.24A 3t3rB-3cmuA:
undetectable		 3t3rB-3cmuA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A3260
ASN A3269
ILE A3268
GLY A3267
THR A3074
 None
None
None
None
ADP  A3502 (-3.7A)
 1.24A 3t3rB-3cmuA:
undetectable		 3t3rB-3cmuA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A4260
ASN A4269
ILE A4268
GLY A4267
THR A4074
 None
None
None
None
ADP  A4502 (-3.8A)
 1.22A 3t3rB-3cmuA:
undetectable		 3t3rB-3cmuA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmu PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A5260
ASN A5269
ILE A5268
GLY A5267
THR A5074
 None
None
None
None
ADP  A5502 (-3.9A)
 1.17A 3t3rB-3cmuA:
undetectable		 3t3rB-3cmuA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 PHE A 260
ASN A 269
ILE A 268
GLY A 267
THR A  74
 None
None
None
None
ANP  A 400 (-3.7A)
 1.30A 3t3rB-3cmvA:
undetectable		 3t3rB-3cmvA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PHE A 244
VAL A 192
ILE A 242
GLY A 204
THR A 368
 None
 1.17A 3t3rB-3dh9A:
undetectable		 3t3rB-3dh9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		5 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
 None
 0.87A 3t3rB-3e3xA:
undetectable		 3t3rB-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382

(Thermotoga
maritima) 		PF00293
(NUDIX) 		5 PHE A  18
PHE A  21
ASN A 133
GLY A 145
PHE A  35
 None
 1.32A 3t3rB-3e57A:
undetectable		 3t3rB-3e57A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e57 UNCHARACTERIZED
PROTEIN TM1382

(Thermotoga
maritima) 		PF00293
(NUDIX) 		5 PHE A  21
PHE A  32
ASN A 133
GLY A 145
PHE A  35
 None
 1.25A 3t3rB-3e57A:
undetectable		 3t3rB-3e57A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed8 YELLOW FLUORESCENCE
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CRO  A  66 ( 3.9A)
None
None
 1.16A 3t3rB-3ed8A:
undetectable		 3t3rB-3ed8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evp GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A 229
VAL A 270
ASN A 279
ILE A 172
PHE A 166
 None
CRO  A 224 ( 4.9A)
CRO  A 224 ( 3.6A)
None
None
 1.21A 3t3rB-3evpA:
undetectable		 3t3rB-3evpA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 PHE A 229
VAL A 270
ASN A 279
ILE A 172
PHE A 166
 None
CRO  A 224 ( 4.8A)
CRO  A 224 ( 3.6A)
None
None
 1.20A 3t3rB-3evrA:
undetectable		 3t3rB-3evrA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		5 PHE A 613
PHE A 609
VAL A 492
ILE A 584
GLY A 539
 None
 1.33A 3t3rB-3gq2A:
undetectable		 3t3rB-3gq2A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		5 PHE M   8
PHE M  96
ILE M 270
GLY M 268
PHE M   4
 None
 1.39A 3t3rB-3i04M:
undetectable		 3t3rB-3i04M:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le2 SERPIN-ZX

(Arabidopsis
thaliana) 		PF00079
(Serpin) 		5 VAL A 372
PHE A 282
ILE A  32
GLY A 384
PHE A 280
 None
 1.29A 3t3rB-3le2A:
undetectable		 3t3rB-3le2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 PHE A 345
VAL A 386
ASN A 395
ILE A 288
PHE A 282
 None
C12  A 340 ( 4.8A)
C12  A 340 ( 3.6A)
None
None
 1.17A 3t3rB-3osqA:
undetectable		 3t3rB-3osqA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		5 PHE A 483
VAL A 524
ASN A 533
ILE A 426
PHE A 420
 None
C12  A 478 ( 4.9A)
C12  A 478 ( 3.5A)
None
None
 1.18A 3t3rB-3osrA:
undetectable		 3t3rB-3osrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p28 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A  23
VAL A  64
ASN A  73
ILE A 206
PHE A 200
 None
GYS  A  18 ( 4.7A)
GYS  A  18 ( 3.6A)
None
None
 1.21A 3t3rB-3p28A:
undetectable		 3t3rB-3p28A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvz UDP-N-ACETYLGLUCOSAM
INE 4,6-DEHYDRATASE

(Aliivibrio
fischeri) 		PF02719
(Polysacc_synt_2) 		5 PHE A 354
PHE A 140
ILE A 358
GLY A 359
PHE A 182
 None
 1.20A 3t3rB-3pvzA:
undetectable		 3t3rB-3pvzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 PHE B 214
VAL B 203
ASN B 210
ILE B 166
GLY B 168
 None
 1.37A 3t3rB-3u0jB:
undetectable		 3t3rB-3u0jB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8p CYTOCHROME B562
INTEGRAL FUSION WITH
ENHANCED GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF07361
(Cytochrom_B562) 		5 PHE A 179
VAL A 220
ASN A 229
ILE A  14
PHE A   8
 None
CRO  A 175 ( 4.8A)
CRO  A 175 ( 3.5A)
None
None
 1.19A 3t3rB-3u8pA:
undetectable		 3t3rB-3u8pA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 VAL A  50
PHE A  63
ASN A 146
GLY A 156
PHE A  59
 None
 1.40A 3t3rB-3ue1A:
undetectable		 3t3rB-3ue1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 PHE A 490
VAL A 494
PHE A 611
ILE A 558
GLY A 555
 None
 1.27A 3t3rB-3ui7A:
undetectable		 3t3rB-3ui7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		5 PHE A  84
VAL A  73
PHE A 317
ILE A  79
GLY A  76
 None
 1.37A 3t3rB-3vr5A:
undetectable		 3t3rB-3vr5A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif PENTON PROTEIN

(Bovine
mastadenovirus
B) 		PF01686
(Adeno_Penton_B) 		5 PHE M 260
PHE M 239
ILE M 250
GLY M 249
THR M 337
 None
 1.11A 3t3rB-3zifM:
undetectable		 3t3rB-3zifM:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		5 PHE A 248
PHE A 241
GLY A 118
THR A 155
PHE A 242
 None
 1.38A 3t3rB-4a5qA:
undetectable		 3t3rB-4a5qA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		5 PHE A1071
VAL A1112
ASN A1121
ILE A1014
PHE A1008
 None
 1.18A 3t3rB-4anjA:
undetectable		 3t3rB-4anjA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX

(Aequorea
victoria;
Homo sapiens) 		PF00452
(Bcl-2)
PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  65 ( 4.3A)
None
None
 1.14A 3t3rB-4bduA:
undetectable		 3t3rB-4bduA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 PHE A 915
PHE A 916
VAL A 910
ILE A 847
GLY A 844
 None
 1.36A 3t3rB-4crsA:
undetectable		 3t3rB-4crsA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		5 VAL A 125
PHE A 110
ILE A  82
GLY A 106
PHE A 133
 None
 1.32A 3t3rB-4fs7A:
undetectable		 3t3rB-4fs7A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqb SINGLE-STRANDED
DNA-BINDING PROTEIN
DDRB

(Deinococcus
radiodurans) 		PF12747
(DdrB) 		5 PHE A  56
VAL A  75
PHE A  48
ILE A  61
PHE A 131
 None
 1.17A 3t3rB-4hqbA:
undetectable		 3t3rB-4hqbA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0n NECROTIC ENTERITIS
TOXIN B

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		5 PHE A 205
PHE A 187
PHE A 226
ILE A 249
THR A 240
 None
 1.30A 3t3rB-4i0nA:
undetectable		 3t3rB-4i0nA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4n INTRACELLULAR
PROTEASE/AMIDASE

(Vibrio cholerae) 		no annotation 5 PHE A 203
PHE A 194
ILE A 184
THR A 261
PHE A 242
 None
 1.33A 3t3rB-4i4nA:
undetectable		 3t3rB-4i4nA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrb GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Blattella
germanica) 		PF01353
(GFP)
PF06757
(Ins_allergen_rp) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.8A)
CR2  A  66 ( 3.6A)
None
None
 1.15A 3t3rB-4jrbA:
undetectable		 3t3rB-4jrbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf5 FLUORESCENT PROTEIN
GFP1-9

(synthetic
construct) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 4.1A)
None
None
 1.21A 3t3rB-4kf5A:
undetectable		 3t3rB-4kf5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		5 PHE A 246
PHE A 168
ILE A 287
GLY A 288
PHE A 170
 None
 1.22A 3t3rB-4mq0A:
undetectable		 3t3rB-4mq0A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN

(Methanopyrus
kandleri) 		PF03787
(RAMPs) 		5 PHE A 270
ILE A 257
GLY A 266
THR A  20
PHE A 224
 None
 1.26A 3t3rB-4n0lA:
undetectable		 3t3rB-4n0lA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,

(Aequorea
victoria;
Eimeria
acervulina) 		PF00046
(Homeobox)
PF01353
(GFP) 		5 PHE A 124
VAL A 165
ASN A 174
ILE A  67
PHE A  61
 None
None
CR2  A 118 ( 4.5A)
None
None
 1.15A 3t3rB-4ndkA:
undetectable		 3t3rB-4ndkA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxr MANGANESE ABC
TRANSPORTER,
PERIPLASMIC-BINDING
PROTEIN SITA

(Staphylococcus
pseudintermedius) 		PF01297
(ZnuA) 		5 PHE A 209
PHE A 206
PHE A 189
ASN A 297
ILE A 301
 None
 1.39A 3t3rB-4oxrA:
undetectable		 3t3rB-4oxrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		5 PHE A 858
VAL A 899
ASN A 908
ILE A 801
PHE A 795
 None
None
CRO  A 853 ( 4.3A)
None
None
 1.17A 3t3rB-4p7hA:
undetectable		 3t3rB-4p7hA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfe GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vicugna pacos) 		PF01353
(GFP)
PF07686
(V-set) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 4.0A)
None
None
 1.23A 3t3rB-4pfeA:
undetectable		 3t3rB-4pfeA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 PHE A 447
PHE A 448
VAL A 442
ILE A 375
GLY A 372
 None
 1.37A 3t3rB-4tnbA:
undetectable		 3t3rB-4tnbA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli) 		PF06007
(PhnJ) 		5 VAL D 175
PHE D 123
ASN D 193
ILE D 188
PHE D 205
 None
 1.37A 3t3rB-4xb6D:
undetectable		 3t3rB-4xb6D:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbi CLPB PROTEIN,
PUTATIVE,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Plasmodium
falciparum) 		PF01353
(GFP)
PF02861
(Clp_N) 		5 PHE A 220
VAL A 261
ASN A 270
ILE A 163
PHE A 157
 None
CRO  A 215 ( 4.9A)
CRO  A 215 ( 3.6A)
None
None
 1.20A 3t3rB-4xbiA:
undetectable		 3t3rB-4xbiA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgy GREEN FLUORESCENT
PROTEIN, MAB LCDR3,
GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Vibrio
parahaemolyticus;
synthetic
construct) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.8A)
CRO  A  66 ( 3.6A)
None
None
 1.19A 3t3rB-4xgyA:
undetectable		 3t3rB-4xgyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1

(Aequorea
victoria;
Homo sapiens) 		PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
 1.20A 3t3rB-4z4mA:
undetectable		 3t3rB-4z4mA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zf4 GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 PHE A  21
VAL A  62
ASN A  71
ILE A 207
PHE A 201
 None
4NT  A  15 ( 4.7A)
4NT  A  15 ( 3.6A)
None
None
 1.19A 3t3rB-4zf4A:
undetectable		 3t3rB-4zf4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv1 ANCQR

(synthetic
construct) 		PF00497
(SBP_bac_3) 		5 PHE A  23
PHE A  20
PHE A  94
GLY A  97
PHE A 231
 None
ARG  A 301 (-3.4A)
None
None
None
 1.26A 3t3rB-4zv1A:
undetectable		 3t3rB-4zv1A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aif LIMONENE-1,2-EPOXIDE
HYDROLASE

(unidentified) 		PF07858
(LEH) 		5 PHE A 118
PHE A 113
VAL A  94
PHE A  53
PHE A  82
 None
IMD  A 200 (-3.6A)
IMD  A 200 ( 4.8A)
None
None
 1.33A 3t3rB-5aifA:
undetectable		 3t3rB-5aifA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 PHE A 417
PHE A 403
ASN A 472
THR A 401
PHE A 371
 None
None
FAD  A 603 (-3.7A)
None
None
 1.30A 3t3rB-5d79A:
undetectable		 3t3rB-5d79A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgu GREEN FLUORESCENT
PROTEIN,EXTRACELLULA
R STREPTODORNASE D

(Aequorea
victoria;
Streptococcus
pyogenes) 		PF01353
(GFP)
PF13930
(Endonuclea_NS_2) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.7A)
None
None
 1.15A 3t3rB-5fguA:
undetectable		 3t3rB-5fguA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 PHE A 254
PHE A 196
ASN A 172
ILE A 459
GLY A 460
 None
 0.84A 3t3rB-5h53A:
undetectable		 3t3rB-5h53A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		5 PHE A  14
VAL B1173
PHE A  22
ILE A  40
THR A  27
 None
 1.35A 3t3rB-5h67A:
undetectable		 3t3rB-5h67A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		5 VAL A 394
PHE A  43
ASN A  54
ILE A  55
GLY A 391
 None
 1.39A 3t3rB-5hgcA:
undetectable		 3t3rB-5hgcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		5 PHE A 226
ASN A 154
ILE A 431
GLY A 432
THR A 222
 None
 1.25A 3t3rB-5hmpA:
undetectable		 3t3rB-5hmpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3n GREEN FLUORESCENT
PROTEIN,HSDR

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF12008
(EcoR124_C) 		5 PHE A  77
VAL A 118
ASN A 127
ILE A  20
PHE A  14
 None
GYS  A  72 ( 4.8A)
GYS  A  72 ( 3.8A)
None
None
 1.15A 3t3rB-5j3nA:
undetectable		 3t3rB-5j3nA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER

(Aequorea
victoria;
Mus musculus) 		PF00452
(Bcl-2)
PF01353
(GFP) 		5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 4.1A)
None
None
 1.15A 3t3rB-5ktgA:
undetectable		 3t3rB-5ktgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5moy BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 PHE A1055
PHE A1072
ASN A 966
ILE A1053
THR A 943
 None
 1.30A 3t3rB-5moyA:
undetectable		 3t3rB-5moyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mse GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		no annotation 5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CRO  A  66 ( 4.9A)
CRO  A  66 ( 3.7A)
None
None
 1.18A 3t3rB-5mseA:
undetectable		 3t3rB-5mseA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 5 PHE A 560
PHE A 722
ILE A 690
GLY A 691
PHE A 784
 None
 0.93A 3t3rB-5n2gA:
undetectable		 3t3rB-5n2gA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		5 PHE A 402
PHE A 342
ILE A 340
GLY A 313
PHE A 412
 None
 1.40A 3t3rB-5szsA:
undetectable		 3t3rB-5szsA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpc BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 PHE A1055
PHE A1072
ASN A 966
ILE A1053
THR A 943
 None
 1.33A 3t3rB-5tpcA:
undetectable		 3t3rB-5tpcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE

(Homo sapiens) 		no annotation 5 PHE A 115
PHE A 120
VAL A 167
ILE A 130
THR A 132
 None
 1.37A 3t3rB-5wy0A:
undetectable		 3t3rB-5wy0A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg5 MITSUBA-1

(synthetic
construct) 		PF14200
(RicinB_lectin_2) 		5 PHE A  44
VAL A  63
PHE A 140
ILE A   6
PHE A  92
 None
 1.29A 3t3rB-5xg5A:
undetectable		 3t3rB-5xg5A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg5 MITSUBA-1

(synthetic
construct) 		PF14200
(RicinB_lectin_2) 		5 PHE A  92
VAL A 111
PHE A  44
ILE A  54
PHE A 140
 None
 1.27A 3t3rB-5xg5A:
undetectable		 3t3rB-5xg5A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg5 MITSUBA-1

(synthetic
construct) 		PF14200
(RicinB_lectin_2) 		5 PHE A 140
VAL A  15
PHE A  92
ILE A 102
PHE A  44
 None
 1.26A 3t3rB-5xg5A:
undetectable		 3t3rB-5xg5A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 PHE A  10
ILE A   8
GLY A  38
THR A  42
PHE A  83
 None
 1.24A 3t3rB-5xsqA:
undetectable		 3t3rB-5xsqA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 5 PHE A 843
VAL A 923
ILE A 830
GLY A 860
THR A 882
 None
 1.30A 3t3rB-5xyaA:
undetectable		 3t3rB-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yba PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Trichomonas
vaginalis) 		no annotation 5 PHE A  37
PHE A 137
PHE A   9
GLY A  72
THR A  59
 None
 1.21A 3t3rB-5ybaA:
undetectable		 3t3rB-5ybaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yba PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Trichomonas
vaginalis) 		no annotation 5 PHE A  37
PHE A 137
PHE A   9
GLY A  73
THR A  59
 None
 1.12A 3t3rB-5ybaA:
undetectable		 3t3rB-5ybaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anz UNCHARACTERIZED
PROTEIN

(Neisseria
gonorrhoeae) 		no annotation 5 PHE A  12
PHE A  36
ILE A  22
GLY A   9
PHE A  42
 None
 1.07A 3t3rB-6anzA:
undetectable		 3t3rB-6anzA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anz UNCHARACTERIZED
PROTEIN

(Neisseria
gonorrhoeae) 		no annotation 5 PHE A  12
PHE A  36
ILE A  22
GLY A  10
PHE A  42
 None
 1.33A 3t3rB-6anzA:
undetectable		 3t3rB-6anzA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b7t GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		no annotation 5 PHE A 101
VAL A 142
ASN A 151
ILE A  44
PHE A  38
 None
GYS  A  96 ( 4.9A)
GYS  A  96 ( 3.6A)
None
None
 1.18A 3t3rB-6b7tA:
undetectable		 3t3rB-6b7tA:
11.84