SIMILAR PATTERNS OF AMINO ACIDS FOR 3T3R_A_9PLA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides)
PF00485
(PRK)
5 PHE A  25
VAL A  21
ILE A 152
GLY A 153
LEU A 268
None
0.82A 3t3rA-1a7jA:
0.0
3t3rA-1a7jA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE


(Escherichia
coli)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
5 PHE A 297
PHE A 415
ILE A 476
GLY A 477
LEU A 484
None
None
None
LAD  A 601 (-3.4A)
None
1.15A 3t3rA-1e1tA:
0.0
3t3rA-1e1tA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE


(Escherichia
coli)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
5 PHE A 297
PHE A 485
PHE A 415
ILE A 476
GLY A 477
None
None
None
None
LAD  A 601 (-3.4A)
1.11A 3t3rA-1e1tA:
0.0
3t3rA-1e1tA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek2 EPOXIDE HYDROLASE

(Mus musculus)
PF00561
(Abhydrolase_1)
PF13419
(HAD_2)
5 PHE A 406
ILE A 427
THR A 402
LEU A 462
PHE A 265
CDU  A1100 (-4.6A)
None
None
None
None
0.93A 3t3rA-1ek2A:
undetectable
3t3rA-1ek2A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00749
(tRNA-synt_1c)
5 PHE A 289
PHE A 284
PHE A  24
GLY A 274
PHE A 293
None
None
None
U  B 513 ( 3.3A)
None
1.12A 3t3rA-1g59A:
0.0
3t3rA-1g59A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iip CYCLOPHILIN 40

(Bos taurus)
PF00160
(Pro_isomerase)
PF13176
(TPR_7)
5 PHE A 132
PHE A  48
PHE A  73
ILE A 178
LEU A  34
None
1.17A 3t3rA-1iipA:
0.0
3t3rA-1iipA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9a CHLOROCATECHOL
1,2-DIOXYGENASE


(Rhodococcus
opacus)
PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N)
5 PHE A 106
PHE A 252
ILE A 197
THR A  70
LEU A 233
None
1.15A 3t3rA-1s9aA:
0.0
3t3rA-1s9aA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uhg OVALBUMIN

(Gallus gallus)
PF00079
(Serpin)
6 VAL A 383
PHE A  15
ASN A  26
ILE A  27
GLY A 380
LEU A 252
None
1.32A 3t3rA-1uhgA:
0.0
3t3rA-1uhgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9t CYCLOPHILIN B

(Escherichia
coli)
PF00160
(Pro_isomerase)
5 PHE A 103
PHE A  32
PHE A  46
ILE A 159
LEU A  18
None
1.11A 3t3rA-1v9tA:
undetectable
3t3rA-1v9tA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE


(Arabidopsis
thaliana)
PF07992
(Pyr_redox_2)
5 VAL A  49
ASN A  51
ILE A 296
LEU A  64
PHE A  68
FAD  A 400 (-3.5A)
FAD  A 400 ( 3.2A)
None
None
None
1.10A 3t3rA-1vdcA:
undetectable
3t3rA-1vdcA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE


(Arabidopsis
thaliana)
PF07992
(Pyr_redox_2)
5 VAL A 204
PHE A 121
ILE A 243
GLY A 152
LEU A 239
None
1.16A 3t3rA-1vdcA:
undetectable
3t3rA-1vdcA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE


(Bos taurus)
PF01048
(PNP_UDP_1)
5 VAL A 102
PHE A 103
ILE A  53
LEU A 106
PHE A  70
None
1.06A 3t3rA-1vfnA:
undetectable
3t3rA-1vfnA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN


(Thermus
thermophilus)
PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
5 PHE B 338
PHE B 360
PHE B 263
ILE B 300
GLY B 312
TYR  B 999 (-4.5A)
TYR  B 999 ( 4.8A)
None
None
None
1.11A 3t3rA-2amcB:
undetectable
3t3rA-2amcB:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekd HYPOTHETICAL PROTEIN
PH0250


(Pyrococcus
horikoshii)
PF03192
(DUF257)
5 PHE A 150
PHE A 152
PHE A  10
LEU A  29
PHE A   6
None
1.17A 3t3rA-2ekdA:
undetectable
3t3rA-2ekdA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esn PROBABLE
TRANSCRIPTIONAL
REGULATOR


(Pseudomonas
aeruginosa)
PF00126
(HTH_1)
PF03466
(LysR_substrate)
5 PHE A 101
PHE A 151
PHE A 103
GLY A 297
LEU A 117
None
1.04A 3t3rA-2esnA:
undetectable
3t3rA-2esnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens)
PF00026
(Asp)
5 PHE A  54
VAL A 113
PHE A 152
ILE A  36
GLY A  37
None
1.02A 3t3rA-2ewyA:
undetectable
3t3rA-2ewyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus)
PF02171
(Piwi)
5 PHE A  88
PHE A  21
GLY A 302
LEU A 100
PHE A  91
None
0.98A 3t3rA-2f8tA:
undetectable
3t3rA-2f8tA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6h HYPOTHETICAL PROTEIN
ATU0120


(Agrobacterium
fabrum)
PF06041
(DUF924)
5 PHE A  15
PHE A  31
GLY A  20
LEU A  66
PHE A  35
None
1.13A 3t3rA-2i6hA:
undetectable
3t3rA-2i6hA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilx 2',3'-CYCLIC-NUCLEOT
IDE
3'-PHOSPHODIESTERASE


(Rattus
norvegicus)
PF05881
(CNPase)
5 PHE A 110
PHE A  46
GLY A 196
LEU A 192
PHE A  39
None
1.13A 3t3rA-2ilxA:
undetectable
3t3rA-2ilxA:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens)
PF00067
(p450)
10 PHE A 107
PHE A 111
VAL A 117
PHE A 118
PHE A 209
ILE A 300
GLY A 301
THR A 305
LEU A 370
PHE A 480
None
None
HEM  A 500 (-3.7A)
None
None
None
HEM  A 500 ( 4.7A)
HEM  A 500 (-3.6A)
HEM  A 500 ( 3.8A)
None
0.62A 3t3rA-2pg6A:
63.9
3t3rA-2pg6A:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens)
PF00067
(p450)
5 PHE A 271
PHE A 267
GLY A 115
LEU A 298
PHE A 440
None
None
None
None
HEM  A 500 (-3.9A)
1.15A 3t3rA-2pg6A:
63.9
3t3rA-2pg6A:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE


(Paraburkholderia
xenovorans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 PHE A  90
GLY A 241
THR A 211
LEU A 189
PHE A 187
None
1.07A 3t3rA-2v7bA:
undetectable
3t3rA-2v7bA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3


(Bacillus
subtilis)
PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C)
5 PHE A 665
PHE A 661
ILE A 531
GLY A 530
LEU A 483
None
1.16A 3t3rA-2vsqA:
undetectable
3t3rA-2vsqA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whd THIOREDOXIN
REDUCTASE


(Hordeum vulgare)
PF07992
(Pyr_redox_2)
5 VAL A 216
PHE A 131
ILE A 253
GLY A 164
LEU A 249
None
None
FLC  A 401 (-4.2A)
FLC  A 401 ( 4.0A)
None
1.13A 3t3rA-2whdA:
undetectable
3t3rA-2whdA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
5 PHE B 149
PHE B 415
ILE B  75
GLY B  76
LEU B 202
ANP  B 432 ( 4.9A)
ANP  B 432 ( 4.9A)
ANP  B 432 (-4.4A)
ANP  B 432 (-3.4A)
ANP  B 432 ( 4.7A)
1.13A 3t3rA-2wtkB:
undetectable
3t3rA-2wtkB:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xty QNRB1

(Klebsiella
pneumoniae)
PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4)
5 PHE A  96
PHE A 101
ILE A  86
LEU A 131
PHE A 126
None
1.12A 3t3rA-2xtyA:
undetectable
3t3rA-2xtyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoo PROBABLE NITRITE
REDUCTASE


(Pseudoalteromonas
haloplanktis)
PF00034
(Cytochrom_C)
PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3)
5 PHE A  72
PHE A 111
VAL A  91
PHE A 113
ILE A  86
None
1.11A 3t3rA-2zooA:
undetectable
3t3rA-2zooA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans)
no annotation 5 VAL A 460
ILE A 468
GLY A 466
LEU A 496
PHE A 527
None
1.00A 3t3rA-3c2gA:
undetectable
3t3rA-3c2gA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
5 PHE A 288
VAL A 217
PHE A 310
ILE A 200
LEU A 227
None
NAG  A 760 (-3.9A)
None
None
None
1.05A 3t3rA-3dkhA:
undetectable
3t3rA-3dkhA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus)
PF00679
(EFG_C)
5 PHE A 179
PHE A 175
ASN A 142
ILE A 139
GLY A 138
None
0.88A 3t3rA-3e3xA:
undetectable
3t3rA-3e3xA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli)
PF00884
(Sulfatase)
5 VAL A 241
ASN A 288
THR A  68
LEU A  53
PHE A 316
None
1.03A 3t3rA-3ed4A:
undetectable
3t3rA-3ed4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fds DNA POLYMERASE
SLIDING CLAMP C


(Sulfolobus
solfataricus)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 VAL D   6
PHE D  57
ILE D  15
LEU D  91
PHE D  28
None
0.72A 3t3rA-3fdsD:
undetectable
3t3rA-3fdsD:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN


(Ralstonia
solanacearum)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 PHE A 109
VAL A 294
ILE A 249
GLY A 246
LEU A 205
None
1.12A 3t3rA-3ghyA:
undetectable
3t3rA-3ghyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc7 GENE 12 PROTEIN

(Mycobacterium
virus D29)
PF01083
(Cutinase)
5 VAL A 200
PHE A 193
ILE A 222
GLY A 184
LEU A 204
None
1.10A 3t3rA-3hc7A:
undetectable
3t3rA-3hc7A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 2
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3


(Thermus
thermophilus)
PF00384
(Molybdopterin)
PF01257
(2Fe-2S_thioredx)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4)
5 ILE 3 211
GLY 3 212
THR 2  58
LEU 3 218
PHE 3 191
SF4  3 785 ( 4.5A)
None
None
None
None
1.05A 3t3rA-3i9v3:
undetectable
3t3rA-3i9v3:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkc TETR FAMILY
TRANSCRIPTIONAL
REGULATOR


(Streptococcus
agalactiae)
PF00440
(TetR_N)
PF14278
(TetR_C_8)
5 PHE A  65
PHE A  69
PHE A 106
ILE A  95
LEU A 114
None
1.06A 3t3rA-3kkcA:
undetectable
3t3rA-3kkcA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 CUBILIN

(Homo sapiens)
PF00431
(CUB)
5 PHE B1270
PHE B1210
PHE B1207
LEU B1205
PHE B1176
None
1.13A 3t3rA-3kq4B:
undetectable
3t3rA-3kq4B:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lca PROTEIN TOM71

(Saccharomyces
cerevisiae)
PF00515
(TPR_1)
PF13181
(TPR_8)
PF14559
(TPR_19)
5 PHE A 273
PHE A 276
ASN A 379
ILE A 353
LEU A 302
None
0.99A 3t3rA-3lcaA:
undetectable
3t3rA-3lcaA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcp GLUCOKINASE

(Parabacteroides
distasonis)
PF00480
(ROK)
5 PHE A 342
ILE A 274
GLY A 243
LEU A 250
PHE A 158
None
1.16A 3t3rA-3mcpA:
undetectable
3t3rA-3mcpA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT BETA-1


(Sus scrofa)
PF00287
(Na_K-ATPase)
5 PHE B 186
ASN B 282
ILE B 283
GLY B 280
LEU B 240
None
0.94A 3t3rA-3n23B:
undetectable
3t3rA-3n23B:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes)
PF01212
(Beta_elim_lyase)
5 VAL A 333
ILE A 317
GLY A 316
LEU A 269
PHE A 351
None
1.07A 3t3rA-3pj0A:
undetectable
3t3rA-3pj0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqy RIBOSOMAL PROTEIN
3/HOMING
ENDONUCLEASE-LIKE
PROTEIN FUSION


(Ophiostoma
novo-ulmi)
PF00961
(LAGLIDADG_1)
5 VAL A 252
PHE A 253
PHE A 237
GLY A 220
LEU A 171
None
0.99A 3t3rA-3qqyA:
undetectable
3t3rA-3qqyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE


(Burkholderia
pseudomallei)
PF00160
(Pro_isomerase)
5 PHE A  98
PHE A  27
PHE A  41
ILE A 157
LEU A  13
None
1.14A 3t3rA-3s6mA:
undetectable
3t3rA-3s6mA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1


(Saccharomyces
cerevisiae)
PF01399
(PCI)
5 PHE B 199
VAL B 179
ASN B 183
LEU B 176
PHE B 211
None
1.09A 3t3rA-3t5vB:
undetectable
3t3rA-3t5vB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wud GALECTIN

(Xenopus laevis)
PF00337
(Gal-bind_lectin)
6 VAL A  99
PHE A 107
PHE A  31
ILE A  33
LEU A 101
PHE A  80
None
1.39A 3t3rA-3wudA:
undetectable
3t3rA-3wudA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX


(Aequorea
victoria;
Homo sapiens)
PF00452
(Bcl-2)
PF01353
(GFP)
5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
None
None
CR2  A  65 ( 4.3A)
None
None
1.17A 3t3rA-4bduA:
undetectable
3t3rA-4bduA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A 280
ILE A 207
GLY A 208
LEU A 277
PHE A 112
None
0.92A 3t3rA-4eutA:
undetectable
3t3rA-4eutA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A 280
ILE A 207
GLY A 208
LEU A 277
PHE A 112
None
0.93A 3t3rA-4euuA:
undetectable
3t3rA-4euuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE


(Homo sapiens)
PF00884
(Sulfatase)
PF14707
(Sulfatase_C)
5 PHE A 284
PHE A 282
PHE A  72
LEU A 372
PHE A  69
None
1.02A 3t3rA-4fdjA:
undetectable
3t3rA-4fdjA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE


(Coffea
canephora)
PF02458
(Transferase)
5 PHE A 389
VAL A  39
PHE A  41
GLY A 394
LEU A 117
None
1.11A 3t3rA-4g0bA:
undetectable
3t3rA-4g0bA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1


([Candida]
glabrata)
PF16796
(Microtub_bd)
5 PHE A 555
VAL A 397
PHE A 557
PHE A 548
LEU A 571
None
0.90A 3t3rA-4gkpA:
undetectable
3t3rA-4gkpA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grc PUTATIVE MEMBRANE
PROTEIN


(Streptomyces
coelicolor)
PF04261
(Dyp_perox)
5 PHE A 363
VAL A 274
GLY A 373
LEU A 165
PHE A 168
HEM  A 502 (-3.9A)
None
None
None
None
0.72A 3t3rA-4grcA:
undetectable
3t3rA-4grcA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica)
PF04261
(Dyp_perox)
5 PHE A 373
VAL A 276
GLY A 383
LEU A 165
PHE A 168
HEM  A 501 (-4.0A)
None
None
GOL  A 503 (-3.8A)
None
0.76A 3t3rA-4gs1A:
undetectable
3t3rA-4gs1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gt2 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO3963


(Streptomyces
coelicolor)
no annotation 5 PHE B 390
VAL B 290
GLY B 400
LEU B 177
PHE B 180
HEM  B 501 (-3.9A)
None
None
None
None
0.75A 3t3rA-4gt2B:
undetectable
3t3rA-4gt2B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE


(Sorghum bicolor)
PF02458
(Transferase)
5 PHE A 403
VAL A  39
PHE A  41
GLY A 408
LEU A 127
None
1.15A 3t3rA-4ke4A:
undetectable
3t3rA-4ke4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgi UNCHARACTERIZED
PROTEIN


(Escherichia
coli)
PF13678
(Peptidase_M85)
5 VAL A  94
PHE A  90
ILE A 108
GLY A 106
LEU A  84
None
1.02A 3t3rA-4lgiA:
undetectable
3t3rA-4lgiA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)


(Parkia
biglobosa)
PF01419
(Jacalin)
5 PHE A 276
PHE A 168
PHE A 170
PHE A 246
ILE A 190
None
1.12A 3t3rA-4mq0A:
undetectable
3t3rA-4mq0A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0l PREDICTED COMPONENT
OF A
THERMOPHILE-SPECIFIC
DNA REPAIR SYSTEM,
CONTAINS A RAMP
DOMAIN


(Methanopyrus
kandleri)
PF03787
(RAMPs)
5 PHE A 224
VAL A  49
GLY A 266
LEU A  54
PHE A 270
None
1.11A 3t3rA-4n0lA:
undetectable
3t3rA-4n0lA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2i NON-LEE ENCODED TYPE
III EFFECTOR C


(Citrobacter
rodentium)
PF13678
(Peptidase_M85)
5 VAL A  94
PHE A  90
ILE A 108
GLY A 106
LEU A  84
None
1.01A 3t3rA-4o2iA:
undetectable
3t3rA-4o2iA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfi TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Marinobacter
hydrocarbonoclasticus)
PF03480
(DctP)
5 PHE A 163
PHE A 149
GLY A 121
LEU A 129
PHE A 145
None
0.90A 3t3rA-4pfiA:
undetectable
3t3rA-4pfiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2


(Blattella
germanica)
PF00026
(Asp)
5 VAL A  38
PHE A 167
ILE A 123
LEU A  89
PHE A 140
None
1.01A 3t3rA-4rldA:
undetectable
3t3rA-4rldA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlq BENZOATE-COENZYME A
LIGASE


(Rhodopseudomonas
palustris)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 PHE A  80
GLY A 231
THR A 201
LEU A 179
PHE A 177
None
1.08A 3t3rA-4rlqA:
undetectable
3t3rA-4rlqA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmy INTELECTIN-1

(Homo sapiens)
no annotation 5 ILE A 149
GLY A 148
THR A 171
LEU A 183
PHE A 238
None
0.94A 3t3rA-4wmyA:
undetectable
3t3rA-4wmyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1y GALECTIN-1

(Homo sapiens)
PF00337
(Gal-bind_lectin)
5 VAL A  98
PHE A 106
PHE A  30
LEU A 100
PHE A  79
CSO  A  88 ( 4.1A)
CSO  A  60 ( 3.8A)
None
None
None
1.05A 3t3rA-4y1yA:
undetectable
3t3rA-4y1yA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7r COENZYME PQQ
SYNTHESIS PROTEIN B


(Methylobacterium
extorquens)
PF12706
(Lactamase_B_2)
5 PHE A 106
VAL A  84
PHE A 124
GLY A  96
LEU A  86
None
1.17A 3t3rA-4z7rA:
undetectable
3t3rA-4z7rA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis)
PF00117
(GATase)
PF06418
(CTP_synth_N)
5 VAL A 295
PHE A 329
PHE A  85
ILE A 256
LEU A 291
None
None
None
ACP  A 602 (-4.7A)
None
1.13A 3t3rA-4zdkA:
undetectable
3t3rA-4zdkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA+,K+-ATPASE BETA
SUBUNIT


(Squalus
acanthias)
PF00287
(Na_K-ATPase)
5 PHE B 187
ASN B 284
ILE B 285
GLY B 282
LEU B 242
None
1.03A 3t3rA-5aw4B:
undetectable
3t3rA-5aw4B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqk ICP27

(Human
alphaherpesvirus
1)
PF05459
(Herpes_UL69)
6 VAL A 429
PHE A 430
ILE A 475
GLY A 471
LEU A 390
PHE A 349
None
1.44A 3t3rA-5bqkA:
undetectable
3t3rA-5bqkA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE


(Methanothermobacter
thermautotrophicus)
PF09414
(RNA_ligase)
6 PHE A 172
VAL A 174
PHE A 140
ILE A 105
LEU A 195
PHE A 139
None
1.44A 3t3rA-5d1pA:
undetectable
3t3rA-5d1pA:
21.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e0e CYTOCHROME P450
FAMILY 2 SUBFAMILY B


(Neotoma lepida)
PF00067
(p450)
5 PHE A 108
VAL A 114
PHE A 115
GLY A 299
THR A 302
None
HEM  A 501 (-3.5A)
None
HEM  A 501 (-3.5A)
CPZ  A 502 ( 4.0A)
0.93A 3t3rA-5e0eA:
51.5
3t3rA-5e0eA:
55.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4c PUTATIVE CYTOPLASMIC
PROTEIN


(Salmonella
enterica)
no annotation 5 PHE A  25
VAL A  42
PHE A  55
ILE A  53
LEU A  38
None
1.16A 3t3rA-5f4cA:
undetectable
3t3rA-5f4cA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN


(Saccharomyces
cerevisiae)
no annotation 5 PHE A 132
PHE A  51
ILE A  94
LEU A 117
PHE A  87
None
1.13A 3t3rA-5fg0A:
undetectable
3t3rA-5fg0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078


(Thermobifida
fusca)
PF04261
(Dyp_perox)
5 PHE A 336
VAL A 239
GLY A 346
LEU A 128
PHE A 131
HEM  A 401 ( 4.0A)
None
None
None
None
0.78A 3t3rA-5fw4A:
undetectable
3t3rA-5fw4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8


(Saccharomyces
cerevisiae)
PF08082
(PRO8NT)
PF08083
(PROCN)
5 PHE A 336
PHE A 352
PHE A 331
ILE A 346
GLY A 348
None
G  U 104 ( 4.6A)
None
None
None
1.11A 3t3rA-5gamA:
undetectable
3t3rA-5gamA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL


(Oryctolagus
cuniculus)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
5 PHE A 254
PHE A 196
ASN A 172
ILE A 459
GLY A 460
None
0.84A 3t3rA-5h53A:
undetectable
3t3rA-5h53A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik8 LAMININ SUBUNIT
ALPHA-2


(Mus musculus)
PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2)
5 VAL A3024
PHE A3080
ILE A3084
THR A2966
LEU A2993
None
1.10A 3t3rA-5ik8A:
undetectable
3t3rA-5ik8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikg DYE-DECOLORIZING
PEROXIDASE


(Auricularia
auricula-judae)
PF04261
(Dyp_perox)
5 PHE A  27
ASN A  30
ILE A  29
THR A  71
LEU A 146
None
1.08A 3t3rA-5ikgA:
undetectable
3t3rA-5ikgA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE


(Arabidopsis
thaliana)
PF02458
(Transferase)
5 PHE A 388
VAL A  39
PHE A  41
GLY A 393
LEU A 117
None
1.16A 3t3rA-5kjuA:
undetectable
3t3rA-5kjuA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjv HYDROXYCINNAMOYL
TRANSFERASE


(Plectranthus
scutellarioides)
PF02458
(Transferase)
5 PHE A 382
VAL A  39
PHE A  41
GLY A 387
LEU A 117
None
1.11A 3t3rA-5kjvA:
undetectable
3t3rA-5kjvA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER


(Aequorea
victoria;
Mus musculus)
PF00452
(Bcl-2)
PF01353
(GFP)
5 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
None
None
CR2  A  66 ( 4.1A)
None
None
1.17A 3t3rA-5ktgA:
undetectable
3t3rA-5ktgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)


(Helicobacter
pylori)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 VAL A 317
PHE A 321
ILE A 432
GLY A 433
LEU A 383
None
0.77A 3t3rA-5lp4A:
undetectable
3t3rA-5lp4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5map DTPA

(Streptomyces
lividans)
PF04261
(Dyp_perox)
5 PHE A 390
VAL A 290
GLY A 400
LEU A 177
PHE A 180
HEM  A 901 (-3.8A)
None
None
None
None
0.76A 3t3rA-5mapA:
undetectable
3t3rA-5mapA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mze 7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE


(Mus musculus)
no annotation 5 PHE A  72
PHE A 137
ILE A  85
GLY A  68
LEU A 150
8DG  A 204 (-3.7A)
None
None
None
None
1.03A 3t3rA-5mzeA:
undetectable
3t3rA-5mzeA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus)
no annotation 5 PHE A 560
PHE A 722
ILE A 690
GLY A 691
PHE A 784
None
0.91A 3t3rA-5n2gA:
undetectable
3t3rA-5n2gA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nr1 FTSZ-BINDING PROTEIN
FZLA


(Caulobacter
vibrioides)
PF00043
(GST_C)
PF13417
(GST_N_3)
5 PHE A 104
PHE A 108
ILE A 150
GLY A 148
LEU A 143
None
1.04A 3t3rA-5nr1A:
undetectable
3t3rA-5nr1A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7h CRISPR-ASSOCIATED
PROTEIN, CSY4 FAMILY


(Shewanella
putrefaciens)
PF09618
(Cas_Csy4)
5 PHE B 155
VAL B  97
PHE B 157
PHE B  25
GLY B 173
None
0.98A 3t3rA-5o7hB:
undetectable
3t3rA-5o7hB:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oq3 CWP19

(Clostridioides
difficile)
no annotation 6 PHE A 194
VAL A 227
PHE A 198
ILE A 176
LEU A 231
PHE A 247
None
1.49A 3t3rA-5oq3A:
undetectable
3t3rA-5oq3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2h I-ONUI_E-HTCRA

(synthetic
construct)
PF00961
(LAGLIDADG_1)
5 VAL A 252
PHE A 253
PHE A 237
GLY A 220
LEU A 171
None
0.99A 3t3rA-5t2hA:
undetectable
3t3rA-5t2hA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8d I-ONUI_E-VHIVINT_V2

(synthetic
construct)
PF00961
(LAGLIDADG_1)
5 VAL A 252
PHE A 253
PHE A 237
GLY A 220
LEU A 171
None
0.97A 3t3rA-5t8dA:
undetectable
3t3rA-5t8dA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2g PENICILLIN-BINDING
PROTEIN 1A


(Haemophilus
influenzae)
PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB)
5 VAL A  69
PHE A  82
ASN A 165
GLY A 175
LEU A 188
None
1.12A 3t3rA-5u2gA:
undetectable
3t3rA-5u2gA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u84 ACID CERAMIDASE

(Balaenoptera
acutorostrata)
no annotation 5 PHE A 136
ILE A 237
GLY A 235
LEU A 167
PHE A  87
None
1.13A 3t3rA-5u84A:
undetectable
3t3rA-5u84A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE


(Malus domestica)
no annotation 5 VAL A 271
PHE A 215
GLY A 305
LEU A 267
PHE A 265
None
1.03A 3t3rA-5uc5A:
undetectable
3t3rA-5uc5A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE


(Homo sapiens)
PF01048
(PNP_UDP_1)
5 VAL A 102
PHE A 103
ILE A  53
LEU A 106
PHE A  70
None
1.06A 3t3rA-5ugfA:
undetectable
3t3rA-5ugfA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqj U6 SNRNA
PHOSPHODIESTERASE


(Saccharomyces
cerevisiae)
PF09749
(HVSL)
5 PHE A 204
PHE A 289
ILE A 276
LEU A 169
PHE A 167
None
1.05A 3t3rA-5uqjA:
undetectable
3t3rA-5uqjA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE


(Paenibacillus
sp. 598K)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110)
5 PHE A1135
VAL A1275
ILE A1190
GLY A1259
LEU A1130
None
1.16A 3t3rA-5x7sA:
undetectable
3t3rA-5x7sA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN


(Electrophorus
electricus)
PF00520
(Ion_trans)
PF06512
(Na_trans_assoc)
5 PHE A 785
ASN A1257
ILE A1260
GLY A1261
LEU A 790
None
1.05A 3t3rA-5xsyA:
undetectable
3t3rA-5xsyA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anz UNCHARACTERIZED
PROTEIN


(Neisseria
gonorrhoeae)
no annotation 5 PHE A  12
PHE A  36
ILE A  22
GLY A   9
PHE A  42
None
1.10A 3t3rA-6anzA:
undetectable
3t3rA-6anzA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE


(Naegleria
fowleri)
no annotation 5 VAL A 135
PHE A 144
GLY A 432
LEU A 186
PHE A 147
None
None
HEM  A 501 ( 3.9A)
None
None
1.13A 3t3rA-6ay4A:
32.2
3t3rA-6ay4A:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3y DENN
DOMAIN-CONTAINING
PROTEIN 3


(Mus musculus)
no annotation 5 PHE A 774
PHE A 771
PHE A 735
ILE A 744
THR A 914
None
1.15A 3t3rA-6b3yA:
undetectable
3t3rA-6b3yA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekt P-47 PROTEIN

(Clostridium
botulinum)
no annotation 5 PHE A  68
ASN A 106
ILE A  88
LEU A 109
PHE A 166
None
1.16A 3t3rA-6ektA:
undetectable
3t3rA-6ektA:
21.91