SIMILAR PATTERNS OF AMINO ACIDS FOR 3T3Q_B_9PLB501_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1anu | COHESIN-2 (Ruminiclostridiumthermocellum) |
PF00963(Cohesin) | 5 | PHE A 35PHE A 119PHE A 96ILE A 5PHE A 37 | None | 1.08A | 3t3qB-1anuA:undetectable | 3t3qB-1anuA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bpl | ALPHA-1,4-GLUCAN-4-GLUCANOHYDROLASE (Bacilluslicheniformis) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | PHE B 292PHE B 343PHE B 350ALA B 349THR B 353 | None | 1.50A | 3t3qB-1bplB:undetectable | 3t3qB-1bplB:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxk | PROTEIN(DTDP-GLUCOSE4,6-DEHYDRATASE) (Escherichiacoli) |
PF16363(GDP_Man_Dehyd) | 5 | PHE A 129PHE A 127ALA A 111THR A 107ILE A 60 | NoneNoneNoneNoneNAD A 380 (-3.9A) | 1.24A | 3t3qB-1bxkA:0.0 | 3t3qB-1bxkA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f5n | INTERFERON-INDUCEDGUANYLATE-BINDINGPROTEIN 1 (Homo sapiens) |
PF02263(GBP)PF02841(GBP_C) | 5 | PHE A 230PHE A 116ALA A 119THR A 98ILE A 43 | None | 1.31A | 3t3qB-1f5nA:0.0 | 3t3qB-1f5nA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f9k | ACIDIC LECTIN (Psophocarpustetragonolobus) |
PF00139(Lectin_legB) | 5 | PHE A 75ASN A 162PHE A 180ALA A 179ILE A 138 | None | 1.29A | 3t3qB-1f9kA:undetectable | 3t3qB-1f9kA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f9k | ACIDIC LECTIN (Psophocarpustetragonolobus) |
PF00139(Lectin_legB) | 5 | PHE A 75PHE A 73PHE A 180ILE A 138PHE A 124 | None | 1.27A | 3t3qB-1f9kA:undetectable | 3t3qB-1f9kA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f9k | ACIDIC LECTIN (Psophocarpustetragonolobus) |
PF00139(Lectin_legB) | 5 | PHE A 75PHE A 180ALA A 179ILE A 138PHE A 124 | None | 1.21A | 3t3qB-1f9kA:undetectable | 3t3qB-1f9kA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iz1 | LYSR-TYPE REGULATORYPROTEIN (Cupriavidusnecator) |
PF00126(HTH_1)PF03466(LysR_substrate) | 5 | PHE A 202ALA A 229THR A 233ILE A 254PHE A 256 | None | 1.48A | 3t3qB-1iz1A:undetectable | 3t3qB-1iz1A:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k5c | ENDOPOLYGALACTURONASE (Chondrostereumpurpureum) |
PF00295(Glyco_hydro_28) | 5 | PHE A 77PHE A 51PHE A 61ILE A 136PHE A 112 | None | 1.23A | 3t3qB-1k5cA:undetectable | 3t3qB-1k5cA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k9o | ALASERPIN (Manduca sexta) |
PF00079(Serpin) | 5 | VAL I 92ASN I 89PHE I 85ILE I 376PHE I 48 | None | 1.14A | 3t3qB-1k9oI:0.0 | 3t3qB-1k9oI:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m93 | SERINE PROTEINASEINHIBITOR 2 (Cowpox virus) |
PF00079(Serpin) | 5 | VAL B 198PHE C 318THR B 291ILE B 284PHE B 238 | None | 0.94A | 3t3qB-1m93B:undetectable | 3t3qB-1m93B:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n47 | ISOLECTIN B4 (Vicia villosa) |
PF00139(Lectin_legB) | 5 | PHE A 73PHE A 71PHE A 180ILE A 138PHE A 124 | None | 1.37A | 3t3qB-1n47A:undetectable | 3t3qB-1n47A:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rro | RAT ONCOMODULIN (Rattus rattus) |
PF13499(EF-hand_7) | 5 | PHE A 29VAL A 106PHE A 30ILE A 2PHE A 70 | None | 1.43A | 3t3qB-1rroA:undetectable | 3t3qB-1rroA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ttx | ONCOMODULIN (Homo sapiens) |
PF13499(EF-hand_7) | 5 | PHE A 30VAL A 107PHE A 31ILE A 51PHE A 67 | None | 1.10A | 3t3qB-1ttxA:undetectable | 3t3qB-1ttxA:12.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xuq | SUPEROXIDE DISMUTASE (Bacillusanthracis) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | VAL A 190PHE A 186ALA A 195ILE A 106PHE A 116 | None | 1.31A | 3t3qB-1xuqA:undetectable | 3t3qB-1xuqA:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ccl | CELLULOSOMALSCAFFOLDING PROTEINA (Ruminiclostridiumthermocellum) |
PF00963(Cohesin) | 5 | PHE A 40PHE A 136PHE A 27ILE A 54PHE A 82 | None | 1.45A | 3t3qB-2cclA:undetectable | 3t3qB-2cclA:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d5r | CCR4-NOTTRANSCRIPTIONCOMPLEX SUBUNIT 7 (Homo sapiens) |
PF04857(CAF1) | 5 | PHE A 188PHE A 189ALA A 137THR A 133ILE A 74 | None | 1.41A | 3t3qB-2d5rA:undetectable | 3t3qB-2d5rA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e7t | BASIC AGGLUTININ (Psophocarpustetragonolobus) |
PF00139(Lectin_legB) | 5 | PHE A 74PHE A 72PHE A 179ILE A 137PHE A 123 | None | 1.38A | 3t3qB-2e7tA:undetectable | 3t3qB-2e7tA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2efe | SMALL GTP-BINDINGPROTEIN-LIKE (Arabidopsisthaliana) |
PF00071(Ras) | 5 | PHE B 90VAL B 105PHE B 149ALA B 142PHE B 98 | None | 1.28A | 3t3qB-2efeB:undetectable | 3t3qB-2efeB:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fia | ACETYLTRANSFERASE (Enterococcusfaecalis) |
PF00583(Acetyltransf_1) | 5 | PHE A 126PHE A 127PHE A 81ALA A 82ILE A 88 | None | 1.28A | 3t3qB-2fiaA:undetectable | 3t3qB-2fiaA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fu0 | CYCLOPHILIN,PUTATIVE (Plasmodiumfalciparum) |
PF00160(Pro_isomerase) | 5 | PHE A 33VAL A 92PHE A 106ILE A 136PHE A 47 | None | 1.22A | 3t3qB-2fu0A:undetectable | 3t3qB-2fu0A:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2glf | PROBABLE M18-FAMILYAMINOPEPTIDASE 1 (Thermotogamaritima) |
PF02127(Peptidase_M18) | 5 | PHE A 102PHE A 222PHE A 161ALA A 190ILE A 210 | None | 1.06A | 3t3qB-2glfA:undetectable | 3t3qB-2glfA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ixm | SERINE/THREONINE-PROTEIN PHOSPHATASE 2AREGULATORY SUBUNITB' (Homo sapiens) |
PF03095(PTPA) | 5 | PHE A 238VAL A 244PHE A 253ILE A 260PHE A 268 | None | 1.41A | 3t3qB-2ixmA:undetectable | 3t3qB-2ixmA:20.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2pg6 | CYTOCHROME P450 2A6 (Homo sapiens) |
PF00067(p450) | 7 | PHE A 107PHE A 111VAL A 117PHE A 118THR A 305ILE A 366PHE A 480 | NoneNoneHEM A 500 (-3.7A)NoneHEM A 500 (-3.6A)HEM A 500 ( 4.1A)None | 0.53A | 3t3qB-2pg6A:64.9 | 3t3qB-2pg6A:98.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qza | SECRETED EFFECTORPROTEIN (Salmonellaenterica) |
PF13599(Pentapeptide_4)PF13979(SopA_C)PF13981(SopA) | 5 | PHE A 243PHE A 197ALA A 200ILE A 205PHE A 207 | None | 1.31A | 3t3qB-2qzaA:undetectable | 3t3qB-2qzaA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r37 | GLUTATHIONEPEROXIDASE 3 (Homo sapiens) |
PF00255(GSHPx) | 5 | PHE A 99VAL A 64PHE A 148ILE A 54PHE A 135 | None | 1.25A | 3t3qB-2r37A:undetectable | 3t3qB-2r37A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2woo | ATPASE GET3 (Schizosaccharomycespombe) |
PF02374(ArsA_ATPase) | 5 | PHE A 157VAL A 212PHE A 216ILE A 136PHE A 146 | None | 1.39A | 3t3qB-2wooA:undetectable | 3t3qB-2wooA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2woo | ATPASE GET3 (Schizosaccharomycespombe) |
PF02374(ArsA_ATPase) | 5 | VAL A 212PHE A 216PHE A 129ILE A 136PHE A 146 | None | 1.12A | 3t3qB-2wooA:undetectable | 3t3qB-2wooA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xsb | HYALURONOGLUCOSAMINIDASE (Oceanicolagranulosus) |
PF07555(NAGidase) | 5 | PHE A 382ASN A 256ALA A 265THR A 268ILE A 284 | None | 1.31A | 3t3qB-2xsbA:undetectable | 3t3qB-2xsbA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a3g | LUMAZINE PROTEIN (Photobacteriumkishitanii) |
PF00677(Lum_binding) | 5 | PHE A 61PHE A 72VAL A 81ASN A 45ILE A 32 | None | 1.36A | 3t3qB-3a3gA:undetectable | 3t3qB-3a3gA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e9p | PRE-MRNA-SPLICINGFACTOR 8 (Saccharomycescerevisiae) |
PF12134(PRP8_domainIV) | 5 | PHE A2005PHE A1844THR A1959ILE A1934PHE A1851 | None | 1.22A | 3t3qB-3e9pA:undetectable | 3t3qB-3e9pA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h3h | UNCHARACTERIZEDSNOAL-LIKE PROTEIN (Burkholderiathailandensis) |
PF12680(SnoaL_2) | 5 | PHE A 106PHE A 8ALA A 9ILE A 90PHE A 104 | None | 1.45A | 3t3qB-3h3hA:undetectable | 3t3qB-3h3hA:13.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hlm | ASPARTATEAMINOTRANSFERASE,MITOCHONDRIAL (Mus musculus) |
PF00155(Aminotran_1_2) | 5 | PHE A 241PHE A 291ALA A 137ILE A 168PHE A 169 | None | 1.16A | 3t3qB-3hlmA:undetectable | 3t3qB-3hlmA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6u | SERINE/THREONINE-PROTEIN KINASE CHK2 (Homo sapiens) |
PF00069(Pkinase)PF00498(FHA) | 5 | PHE A 199ASN A 105PHE A 103ALA A 104PHE A 115 | None | 1.49A | 3t3qB-3i6uA:undetectable | 3t3qB-3i6uA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iqx | TAIL-ANCHOREDPROTEIN TARGETINGFACTOR GET3 (Chaetomiumthermophilum) |
PF02374(ArsA_ATPase) | 5 | PHE A 166VAL A 224PHE A 228ILE A 153PHE A 155 | None | 1.19A | 3t3qB-3iqxA:undetectable | 3t3qB-3iqxA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2w | BETAINE-ALDEHYDEDEHYDROGENASE (Pseudoalteromonasatlantica) |
PF00171(Aldedh) | 5 | VAL A 208ALA A 163THR A 112ILE A 83PHE A 79 | None | 1.08A | 3t3qB-3k2wA:undetectable | 3t3qB-3k2wA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ljf | IRON SUPEROXIDEDISMUTASE (Pseudoalteromonashaloplanktis) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | VAL A 182PHE A 178ALA A 187ILE A 96PHE A 106 | None | 1.26A | 3t3qB-3ljfA:undetectable | 3t3qB-3ljfA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lvv | GLUTAMATE--CYSTEINELIGASE (Saccharomycescerevisiae) |
PF03074(GCS) | 5 | PHE A 471PHE A 474PHE A 289ILE A 550PHE A 554 | None | 1.32A | 3t3qB-3lvvA:undetectable | 3t3qB-3lvvA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3muq | UNCHARACTERIZEDCONSERVED PROTEIN (Vibrioparahaemolyticus) |
PF12849(PBP_like_2) | 5 | VAL A 77ALA A 68THR A 82ILE A 223PHE A 91 | None | 1.48A | 3t3qB-3muqA:undetectable | 3t3qB-3muqA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nr8 | PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE5-PHOSPHATASE 2 (Homo sapiens) |
no annotation | 5 | PHE B 555PHE B 603VAL B 468PHE B 557ILE B 522 | None | 1.34A | 3t3qB-3nr8B:undetectable | 3t3qB-3nr8B:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o53 | PROTEIN LRIM1 (Anophelesgambiae) |
PF00560(LRR_1)PF13855(LRR_8) | 5 | PHE A 264PHE A 257ASN A 283PHE A 280THR A 275 | None | 1.48A | 3t3qB-3o53A:undetectable | 3t3qB-3o53A:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sbg | PRE-MRNA-SPLICINGFACTOR 8 (Saccharomycescerevisiae) |
PF08084(PROCT)PF12134(PRP8_domainIV) | 5 | PHE A2005PHE A1844THR A1959ILE A1934PHE A1851 | None | 1.25A | 3t3qB-3sbgA:undetectable | 3t3qB-3sbgA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6o | SULFATETRANSPORTER/ANTISIGMA-FACTOR ANTAGONISTSTAS (Planctopiruslimnophila) |
no annotation | 5 | VAL A 48PHE A 81ALA A 39THR A 35ILE A 4 | None | 1.11A | 3t3qB-3t6oA:undetectable | 3t3qB-3t6oA:13.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tk3 | CYTOCHROME P450 2B4 (Oryctolaguscuniculus) |
PF00067(p450) | 5 | PHE A 108PHE A 115ALA A 298THR A 302ILE A 363 | NoneNoneCPZ A 501 (-3.5A)CPZ A 501 ( 3.7A)HEM A 500 ( 3.9A) | 0.57A | 3t3qB-3tk3A:56.8 | 3t3qB-3tk3A:56.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tk3 | CYTOCHROME P450 2B4 (Oryctolaguscuniculus) |
PF00067(p450) | 5 | PHE A 108PHE A 297ALA A 298THR A 302ILE A 363 | NoneCPZ A 501 (-4.3A)CPZ A 501 (-3.5A)CPZ A 501 ( 3.7A)HEM A 500 ( 3.9A) | 1.03A | 3t3qB-3tk3A:56.8 | 3t3qB-3tk3A:56.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u44 | ATP-DEPENDENTHELICASE/DEOXYRIBONUCLEASE SUBUNIT B (Bacillussubtilis) |
PF12705(PDDEXK_1) | 5 | PHE B 213PHE B 218PHE B 68ILE B 231PHE B 233 | None | 1.39A | 3t3qB-3u44B:undetectable | 3t3qB-3u44B:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zef | PRE-MRNA-SPLICINGFACTOR 8 (Saccharomycescerevisiae) |
PF08084(PROCT)PF10596(U6-snRNA_bdg)PF10597(U5_2-snRNA_bdg)PF10598(RRM_4)PF12134(PRP8_domainIV) | 5 | PHE B2005PHE B1844THR B1959ILE B1934PHE B1851 | None | 1.15A | 3t3qB-3zefB:undetectable | 3t3qB-3zefB:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4awe | ENDO-BETA-D-1,4-MANNANASE (Neurosporasitophila) |
PF00150(Cellulase) | 5 | PHE A 14PHE A 21VAL A 53PHE A 23PHE A 262 | None | 1.38A | 3t3qB-4aweA:undetectable | 3t3qB-4aweA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4czd | PUTATIVETRANSCRIPTIONALREGULATOR, ASNCFAMILY (Desulfovibriodesulfuricans) |
PF13404(HTH_AsnC-type)no annotation | 5 | PHE B 158VAL B 12PHE B 5ILE B 54PHE A 79 | None | 1.27A | 3t3qB-4czdB:undetectable | 3t3qB-4czdB:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dag | FUSION GLYCOPROTEINF0 (Humanmetapneumovirus) |
PF00523(Fusion_gly) | 5 | PHE A 334PHE A 276ASN A 247ALA A 249ILE A 217 | None | 1.30A | 3t3qB-4dagA:undetectable | 3t3qB-4dagA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dhi | UBIQUITINTHIOESTERASEOTUBAIN-LIKE (Caenorhabditiselegans) |
PF10275(Peptidase_C65) | 5 | PHE B 172PHE B 139ALA B 225THR B 227ILE B 100 | None | 1.41A | 3t3qB-4dhiB:undetectable | 3t3qB-4dhiB:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dm4 | CELL DIVISIONCONTROL PROTEIN 73 (Saccharomycescerevisiae) |
PF05179(CDC73_C) | 5 | PHE A 110ASN A 21PHE A 25ILE A 7PHE A 82 | None | 1.36A | 3t3qB-4dm4A:undetectable | 3t3qB-4dm4A:15.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fch | OUTER MEMBRANEPROTEIN SUSE (Bacteroidesthetaiotaomicron) |
PF16411(SusF_SusE) | 5 | PHE A 263PHE A 280VAL A 239ILE A 230PHE A 222 | None | 1.43A | 3t3qB-4fchA:undetectable | 3t3qB-4fchA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fem | OUTER MEMBRANEPROTEIN SUSE (Bacteroidesthetaiotaomicron) |
PF16411(SusF_SusE) | 5 | PHE A 263PHE A 280VAL A 239ILE A 230PHE A 222 | None | 1.45A | 3t3qB-4femA:undetectable | 3t3qB-4femA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnm | E3 ALPHA-ESTERASE-7CARBOXYLESTERASE (Lucilia cuprina) |
PF00135(COesterase) | 5 | PHE A 153PHE A 479ASN A 162THR A 213ILE A 241 | None | 1.35A | 3t3qB-4fnmA:undetectable | 3t3qB-4fnmA:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzv | PUTATIVEMETHYLTRANSFERASENSUN4 (Homo sapiens) |
PF01189(Methyltr_RsmB-F) | 5 | PHE A 348VAL A 364PHE A 354PHE A 98PHE A 344 | None | 1.47A | 3t3qB-4fzvA:undetectable | 3t3qB-4fzvA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fzw | 1,2-EPOXYPHENYLACETYL-COA ISOMERASE (Escherichiacoli) |
PF00378(ECH_1) | 5 | PHE C 60ASN C 107ALA C 127ILE C 181PHE C 132 | None | 1.35A | 3t3qB-4fzwC:undetectable | 3t3qB-4fzwC:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gmj | CCR4-NOTTRANSCRIPTIONCOMPLEX SUBUNIT 7 (Homo sapiens) |
PF04857(CAF1) | 5 | PHE B 188PHE B 189ALA B 137THR B 133ILE B 74 | NoneNoneNone CL B 304 ( 4.7A) CL B 304 (-4.3A) | 1.40A | 3t3qB-4gmjB:undetectable | 3t3qB-4gmjB:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l22 | PHOSPHORYLASE (Streptococcusmutans) |
PF00343(Phosphorylase) | 5 | ASN A 612PHE A 609ALA A 614THR A 616ILE A 627 | None | 1.40A | 3t3qB-4l22A:undetectable | 3t3qB-4l22A:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oj5 | TAILSPIKE PROTEIN (Escherichiavirus CBA120) |
no annotation | 5 | PHE A 450ASN A 408ALA A 410ILE A 455PHE A 462 | None | 1.22A | 3t3qB-4oj5A:undetectable | 3t3qB-4oj5A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qg5 | PUTATIVEPHOSPHOGLUCOMUTASE (Leishmaniamajor) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | PHE A 113ASN A 133ALA A 140ILE A 148PHE A 34 | None | 1.48A | 3t3qB-4qg5A:undetectable | 3t3qB-4qg5A:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qp0 | ENDO-BETA-MANNANASE (Rhizomucormiehei) |
PF00150(Cellulase) | 5 | PHE A 12PHE A 19VAL A 51PHE A 21PHE A 252 | None | 1.45A | 3t3qB-4qp0A:undetectable | 3t3qB-4qp0A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uzu | ALPHA-AMYLASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | PHE A 293PHE A 344PHE A 351ALA A 350THR A 354 | None | 1.49A | 3t3qB-4uzuA:undetectable | 3t3qB-4uzuA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4v33 | POLYSACCHARIDEDEACETYLASE-LIKEPROTEIN (Bacillusanthracis) |
PF01522(Polysacc_deac_1) | 5 | PHE A 204ASN A 213PHE A 170ILE A 258PHE A 259 | None | 1.43A | 3t3qB-4v33A:undetectable | 3t3qB-4v33A:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5az4 | FLAGELLAR HOOKSUBUNIT PROTEIN (Campylobacterjejuni) |
PF07196(Flagellin_IN)PF07559(FlaE) | 5 | PHE A 599PHE A 602VAL A 257PHE A 545PHE A 595 | None | 1.31A | 3t3qB-5az4A:undetectable | 3t3qB-5az4A:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dxf | TREHALOSE-6-PHOSPHATE PHOSPHATASE (Candidaalbicans) |
PF00982(Glyco_transf_20) | 5 | PHE A 259PHE A 226ALA A 254ILE A 523PHE A 519 | None | 1.46A | 3t3qB-5dxfA:undetectable | 3t3qB-5dxfA:21.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e0e | CYTOCHROME P450FAMILY 2 SUBFAMILY B (Neotoma lepida) |
PF00067(p450) | 6 | PHE A 108VAL A 114PHE A 115ALA A 298THR A 302ILE A 363 | NoneHEM A 501 (-3.5A)NoneHEM A 501 ( 3.1A)CPZ A 502 ( 4.0A)HEM A 501 (-4.1A) | 0.90A | 3t3qB-5e0eA:51.7 | 3t3qB-5e0eA:56.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e0e | CYTOCHROME P450FAMILY 2 SUBFAMILY B (Neotoma lepida) |
PF00067(p450) | 5 | PHE A 115PHE A 297ALA A 298THR A 302ILE A 363 | NoneNoneHEM A 501 ( 3.1A)CPZ A 502 ( 4.0A)HEM A 501 (-4.1A) | 1.20A | 3t3qB-5e0eA:51.7 | 3t3qB-5e0eA:56.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gkm | AT5G51070/K3K7_27 (Arabidopsisthaliana) |
PF02861(Clp_N) | 5 | PHE A 176PHE A 83PHE A 80ALA A 90PHE A 168 | None | 1.46A | 3t3qB-5gkmA:undetectable | 3t3qB-5gkmA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jou | ALPHA-XYLOSIDASEBOGH31A (Bacteroidesovatus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 5 | PHE A 169ASN A 647ALA A 649THR A 758ILE A 388 | None | 1.48A | 3t3qB-5jouA:undetectable | 3t3qB-5jouA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kds | F5/8 TYPE C DOMAINPROTEIN (Clostridiumperfringens) |
PF13402(Peptidase_M60) | 5 | PHE A 781VAL A 754ASN A 749ALA A 748ILE A 692 | None | 1.31A | 3t3qB-5kdsA:undetectable | 3t3qB-5kdsA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5liv | CYTOCHROME P450CYP260A1,CYTOCHROMEP450 CYP260A1 (Sorangiumcellulosum) |
PF00067(p450) | 5 | PHE A 69ASN A 358ALA A 356ILE A 92PHE A 59 | None | 1.45A | 3t3qB-5livA:28.5 | 3t3qB-5livA:25.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oko | PHOSPHATIDYLINOSITOL3,4,5-TRISPHOSPHATE5-PHOSPHATASE 2 (Homo sapiens) |
PF03372(Exo_endo_phos) | 5 | PHE A 555PHE A 603VAL A 468PHE A 557ILE A 522 | None | 1.43A | 3t3qB-5okoA:undetectable | 3t3qB-5okoA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vev | PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (Neisseriagonorrhoeae) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | VAL A 333ALA A 364THR A 366ILE A 349PHE A 407 | None | 1.24A | 3t3qB-5vevA:undetectable | 3t3qB-5vevA:20.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5wbg | CYTOCHROME P450 2B6 (Homo sapiens) |
no annotation | 5 | PHE A 108PHE A 115PHE A 297ALA A 298THR A 302 | 9ZJ A 502 (-4.4A)9ZJ A 502 (-4.7A)9ZJ A 502 ( 4.5A)9ZJ A 502 ( 3.5A)9ZJ A 502 ( 3.9A) | 0.51A | 3t3qB-5wbgA:56.4 | 3t3qB-5wbgA:66.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x4s | SPIKE GLYCOPROTEIN (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF16451(Spike_NTD) | 5 | PHE A 103PHE A 83ASN A 189PHE A 187ILE A 125 | None | 1.44A | 3t3qB-5x4sA:undetectable | 3t3qB-5x4sA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6byw | GOXA (Pseudoalteromonasluteoviolacea) |
no annotation | 5 | PHE B 535VAL B 395PHE B 392ILE B 422PHE B 431 | None | 1.38A | 3t3qB-6bywB:undetectable | 3t3qB-6bywB:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dft | - (-) |
no annotation | 5 | PHE B 150PHE B 146ALA B 99THR B 97ILE B 75 | NoneNoneNAD B 500 (-3.2A)NoneNone | 1.00A | 3t3qB-6dftB:undetectable | 3t3qB-6dftB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ewp | CENTROSOMAL PROTEINOF 120 KDA (Mus musculus) |
no annotation | 5 | PHE A 486PHE A 517PHE A 459ALA A 514ILE A 492 | None | 1.30A | 3t3qB-6ewpA:undetectable | 3t3qB-6ewpA:11.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f85 | CYTOCHROME P450CYP260A1 (Sorangiumcellulosum) |
no annotation | 5 | PHE A 19ASN A 308ALA A 306ILE A 42PHE A 9 | None | 1.46A | 3t3qB-6f85A:28.8 | 3t3qB-6f85A:9.45 |