SIMILAR PATTERNS OF AMINO ACIDS FOR 3T3C_A_017A201_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bs9 | ACETYL XYLANESTERASE (Talaromycespurpureogenus) |
PF01083(Cutinase) | 5 | VAL A 72ILE A 84ILE A 167ALA A 99VAL A 68 | None | 0.95A | 3t3cB-1bs9A:undetectable | 3t3cB-1bs9A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ded | CYCLODEXTRINGLUCANOTRANSFERASE (Bacillus sp.1011) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 5 | ASP A 319VAL A 355GLY A 225ALA A 357VAL A 321 | None | 1.03A | 3t3cB-1dedA:undetectable | 3t3cB-1dedA:10.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ga8 | GALACTOSYLTRANSFERASE LGTC (Neisseriameningitidis) |
PF01501(Glyco_transf_8) | 5 | ASP A 2VAL A 4ILE A 93GLY A 90ILE A 169 | None | 0.91A | 3t3cB-1ga8A:undetectable | 3t3cB-1ga8A:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpl | RP2 LIPASE (Cavia porcellus) |
PF00151(Lipase)PF01477(PLAT) | 5 | ALA A 161VAL A 124GLY A 150ILE A 149VAL A 128 | None | 0.96A | 3t3cB-1gplA:undetectable | 3t3cB-1gplA:13.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hpl | LIPASE (Equus caballus) |
PF00151(Lipase)PF01477(PLAT) | 5 | ALA A 161VAL A 124GLY A 150ILE A 149VAL A 128 | None | 0.98A | 3t3cB-1hplA:undetectable | 3t3cB-1hplA:13.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 ( 4.9A)A79 A 800 ( 4.4A)A79 A 800 ( 3.2A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A) | 0.81A | 3t3cB-1hvcA:12.6 | 3t3cB-1hvcA:40.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 ( 4.7A)A79 A 800 ( 4.3A)A79 A 800 ( 3.4A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A) | 0.70A | 3t3cB-1hvcA:12.6 | 3t3cB-1hvcA:40.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k9m | RIBOSOMAL PROTEINL10E (Haloarculamarismortui) |
PF00252(Ribosomal_L16) | 5 | VAL J 92ILE J 23GLY J 25PRO J 89ALA J 122 | None | 1.01A | 3t3cB-1k9mJ:undetectable | 3t3cB-1k9mJ:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lpb | LIPASE (Homo sapiens) |
PF00151(Lipase)PF01477(PLAT) | 5 | ALA B 161VAL B 124GLY B 150ILE B 149VAL B 128 | None | 0.97A | 3t3cB-1lpbB:undetectable | 3t3cB-1lpbB:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o94 | TRIMETHYLAMINEDEHYDROGENASE (Methylophilusmethylotrophus) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 5 | ASP A 390VAL A 392ILE A 695ALA A 405VAL A 415 | None | 0.99A | 3t3cB-1o94A:undetectable | 3t3cB-1o94A:9.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1odt | CEPHALOSPORIN CDEACETYLASE (Bacillussubtilis) |
PF05448(AXE1) | 5 | ALA C 106VAL C 56PRO C 50ALA C 51VAL C 54 | None | 0.90A | 3t3cB-1odtC:undetectable | 3t3cB-1odtC:14.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 30VAL A 32PRO A 81 | None | 0.77A | 3t3cB-1q9pA:9.1 | 3t3cB-1q9pA:73.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qvr | CLPB PROTEIN (Thermusthermophilus) |
PF00004(AAA)PF02861(Clp_N)PF07724(AAA_2)PF10431(ClpB_D2-small) | 5 | ALA A 389ILE A 529ILE A 382ALA A 360VAL A 521 | NoneNoneANP A 901 (-4.5A)NoneNone | 1.02A | 3t3cB-1qvrA:undetectable | 3t3cB-1qvrA:8.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rp1 | PANCREATIC LIPASERELATED PROTEIN 1 (Canis lupus) |
PF00151(Lipase)PF01477(PLAT) | 5 | ALA A 161VAL A 124GLY A 150ILE A 149VAL A 128 | None | 1.03A | 3t3cB-1rp1A:undetectable | 3t3cB-1rp1A:12.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ru3 | ACETYL-COA SYNTHASE (Carboxydothermushydrogenoformans) |
PF03598(CdhC) | 5 | ALA A 113VAL A 218GLY A 106ALA A 222VAL A 219 | None | 1.02A | 3t3cB-1ru3A:undetectable | 3t3cB-1ru3A:9.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s72 | 50S RIBOSOMALPROTEIN L10E (Haloarculamarismortui) |
PF00252(Ribosomal_L16) | 5 | VAL H 94ILE H 23GLY H 25PRO H 91ALA H 124 | None | 1.00A | 3t3cB-1s72H:undetectable | 3t3cB-1s72H:19.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 30ILE A 50PRO A 81 | None | 0.71A | 3t3cB-1sivA:19.2 | 3t3cB-1sivA:49.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81 | None | 0.47A | 3t3cB-1sivA:19.2 | 3t3cB-1sivA:49.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1up4 | 6-PHOSPHO-BETA-GLUCOSIDASE (Thermotogamaritima) |
PF02056(Glyco_hydro_4)PF11975(Glyco_hydro_4C) | 5 | VAL A 120ILE A 145GLY A 160ILE A 159VAL A 124 | None | 0.84A | 3t3cB-1up4A:undetectable | 3t3cB-1up4A:14.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vcv | PROBABLEDEOXYRIBOSE-PHOSPHATE ALDOLASE (Pyrobaculumaerophilum) |
PF01791(DeoC) | 5 | ALA A 142VAL A 85PRO A 88ALA A 87VAL A 118 | None | 1.02A | 3t3cB-1vcvA:undetectable | 3t3cB-1vcvA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vzo | RIBOSOMAL PROTEIN S6KINASE ALPHA 5 (Homo sapiens) |
PF00069(Pkinase) | 6 | ASP A 325VAL A 331ILE A 321GLY A 159PRO A 334ALA A 333 | None | 1.37A | 3t3cB-1vzoA:undetectable | 3t3cB-1vzoA:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x3l | HYPOTHETICAL PROTEINPH0495 (Pyrococcushorikoshii) |
PF05161(MOFRL)PF13660(DUF4147) | 5 | ALA A 351ILE A 347GLY A 379ILE A 380ALA A 431 | None | 0.99A | 3t3cB-1x3lA:undetectable | 3t3cB-1x3lA:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xi8 | MOLYBDENUM COFACTORBIOSYNTHESIS PROTEIN (Pyrococcusfuriosus) |
PF00994(MoCF_biosynth)PF03453(MoeA_N)PF03454(MoeA_C) | 5 | ALA A 243ILE A 256GLY A 186ILE A 228VAL A 233 | None | 1.00A | 3t3cB-1xi8A:undetectable | 3t3cB-1xi8A:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z94 | CONSERVEDHYPOTHETICAL PROTEIN (Chromobacteriumviolaceum) |
PF08327(AHSA1) | 6 | ALA A 21ASP A 24GLY A 77PRO A 14ALA A 13VAL A 141 | None | 1.49A | 3t3cB-1z94A:undetectable | 3t3cB-1z94A:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dul | N(2),N(2)-DIMETHYLGUANOSINE TRNAMETHYLTRANSFERASE (Pyrococcushorikoshii) |
PF02005(TRM) | 5 | VAL A 231ILE A 204ILE A 199ALA A 220VAL A 217 | None | 0.98A | 3t3cB-2dulA:undetectable | 3t3cB-2dulA:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 6 | ASP A 25ALA A 28VAL A 32ILE A 53GLY A 55PRO A 86 | LP1 A 201 (-2.3A)LP1 A 201 (-3.5A)NoneLP1 A 201 (-4.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A) | 0.42A | 3t3cB-2fmbA:15.3 | 3t3cB-2fmbA:29.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hsd | 3-ALPHA, 20BETA-HYDROXYSTEROIDDEHYDROGENASE (Streptomycesexfoliatus) |
PF13561(adh_short_C2) | 5 | ILE A 134GLY A 118PRO A 124ALA A 125VAL A 81 | None | 0.92A | 3t3cB-2hsdA:undetectable | 3t3cB-2hsdA:16.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jsz | PROBABLE THIOLPEROXIDASE (Bacillussubtilis) |
PF08534(Redoxin) | 5 | ALA A 143GLY A 118PRO A 25ALA A 24VAL A 140 | None | 0.93A | 3t3cB-2jszA:undetectable | 3t3cB-2jszA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k6d | SH3DOMAIN-CONTAININGKINASE-BINDINGPROTEIN 1 (Homo sapiens) |
PF14604(SH3_9) | 6 | ASP A 320VAL A 274ILE A 288GLY A 309ILE A 297VAL A 323 | None | 1.39A | 3t3cB-2k6dA:undetectable | 3t3cB-2k6dA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oas | 4-HYDROXYBUTYRATECOENZYME ATRANSFERASE (Shewanellaoneidensis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 6 | ALA A 350VAL A 197ILE A 304GLY A 210ILE A 211ALA A 217 | None | 1.16A | 3t3cB-2oasA:undetectable | 3t3cB-2oasA:13.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ppl | PANCREATICLIPASE-RELATEDPROTEIN 1 (Homo sapiens) |
PF00151(Lipase)PF01477(PLAT) | 5 | ALA A 180VAL A 143GLY A 169ILE A 168VAL A 147 | None | 0.99A | 3t3cB-2pplA:undetectable | 3t3cB-2pplA:11.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q6t | DNAB REPLICATIONFORK HELICASE (Thermusaquaticus) |
PF00772(DnaB)PF03796(DnaB_C) | 5 | ALA A 224ILE A 285GLY A 233ILE A 314ALA A 217 | None | 1.04A | 3t3cB-2q6tA:undetectable | 3t3cB-2q6tA:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qqk | NEUROPILIN-2 (Homo sapiens) |
PF00431(CUB)PF00754(F5_F8_type_C) | 5 | ASP A 491VAL A 490ILE A 445GLY A 443ALA A 465 | None | 1.05A | 3t3cB-2qqkA:undetectable | 3t3cB-2qqkA:10.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdx | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME,PUTATIVE (Roseovariusnubinhibens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 203ASP A 201ILE A 177ALA A 234VAL A 230 | None | 1.00A | 3t3cB-2rdxA:undetectable | 3t3cB-2rdxA:16.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 30GLY A 49PRO A 81ALA A 82 | AB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-3.5A)AB1 A 501 (-4.2A)AB1 A 501 (-3.6A) | 0.67A | 3t3cB-2rkfA:19.0 | 3t3cB-2rkfA:72.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ALA A 82 | AB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 (-3.6A) | 0.52A | 3t3cB-2rkfA:19.0 | 3t3cB-2rkfA:72.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v82 | 2-DEHYDRO-3-DEOXY-6-PHOSPHOGALACTONATEALDOLASE (Escherichiacoli) |
PF01081(Aldolase) | 5 | ALA A 60VAL A 25ILE A 52GLY A 63ALA A 11 | None | 1.05A | 3t3cB-2v82A:undetectable | 3t3cB-2v82A:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5e | PUTATIVE SERINEPROTEASE (Mamastrovirus 1) |
PF13365(Trypsin_2) | 5 | ASP A 489ILE A 490ILE A 456PRO A 554ALA A 553 | None | 0.99A | 3t3cB-2w5eA:undetectable | 3t3cB-2w5eA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9f | CELL DIVISIONPROTEIN KINASE 4 (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL B 37ILE B 164ILE B 51PRO B 40VAL B 89 | None | 1.05A | 3t3cB-2w9fB:undetectable | 3t3cB-2w9fB:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a0h | PHOTOSYSTEM II CORELIGHT HARVESTINGPROTEIN (Thermosynechococcusvulcanus) |
PF00421(PSII) | 5 | ASP B 380VAL B 368ILE B 381ALA B 424VAL B 356 | None | 0.99A | 3t3cB-3a0hB:undetectable | 3t3cB-3a0hB:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai7 | XYLULOSE-5-PHOSPHATE/FRUCTOSE-6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacteriumlongum) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 5 | ALA A 167VAL A 90ILE A 151ALA A 178VAL A 176 | None | 0.88A | 3t3cB-3ai7A:undetectable | 3t3cB-3ai7A:8.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bfo | MUCOSA-ASSOCIATEDLYMPHOID TISSUELYMPHOMATRANSLOCATIONPROTEIN 1 (ISOFORM2) (Homo sapiens) |
PF13895(Ig_2) | 5 | ASP A 281VAL A 280ILE A 308GLY A 286VAL A 277 | None | 1.03A | 3t3cB-3bfoA:undetectable | 3t3cB-3bfoA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cp0 | MEMBRANE PROTEINIMPLICATED INREGULATION OFMEMBRANE PROTEASEACTIVITY (Corynebacteriumglutamicum) |
PF01957(NfeD) | 5 | ALA A 48VAL A 28ILE A 66ALA A 26VAL A 39 | None | 0.96A | 3t3cB-3cp0A:undetectable | 3t3cB-3cp0A:26.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fj1 | PUTATIVEPHOSPHOSUGARISOMERASE (Ruegeriapomeroyi) |
PF01380(SIS) | 5 | ALA A 281VAL A 256ILE A 249ALA A 273VAL A 283 | None | 1.04A | 3t3cB-3fj1A:undetectable | 3t3cB-3fj1A:12.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyd | CYCLICNUCLEOTIDE-BINDINGDOMAIN (Methylobacillusflagellatus) |
PF00027(cNMP_binding) | 5 | ALA A 93VAL A 72GLY A 96ALA A 87VAL A 89 | NoneNoneCMP A 300 (-3.3A)CMP A 300 (-3.3A)None | 0.88A | 3t3cB-3gydA:undetectable | 3t3cB-3gydA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j09 | COPPER-EXPORTINGP-TYPE ATPASE A (Archaeoglobusfulgidus) |
PF00122(E1-E2_ATPase)PF00403(HMA)PF00702(Hydrolase) | 5 | ASP A 424ILE A 620GLY A 277PRO A 624ALA A 625 | None | 1.04A | 3t3cB-3j09A:undetectable | 3t3cB-3j09A:10.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lez | BETA-LACTAMASE (Oceanobacillusiheyensis) |
PF13354(Beta-lactamase2) | 7 | ALA A 64ASP A 66ILE A 262GLY A 260ILE A 259ALA A 294VAL A 298 | None | 1.22A | 3t3cB-3lezA:undetectable | 3t3cB-3lezA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3meq | ALCOHOLDEHYDROGENASE,ZINC-CONTAINING (Brucella suis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 38ILE A 147GLY A 88ILE A 89VAL A 339 | None | 1.01A | 3t3cB-3meqA:undetectable | 3t3cB-3meqA:15.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81 | None | 0.40A | 3t3cB-3mwsA:20.0 | 3t3cB-3mwsA:69.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qt4 | CATHEPSIN-L-LIKEMIDGUT CYSTEINEPROTEINASE (Tenebriomolitor) |
PF00112(Peptidase_C1)PF08246(Inhibitor_I29) | 5 | VAL A 263ILE A 303GLY A 214ALA A 222VAL A 229 | None | 0.96A | 3t3cB-3qt4A:undetectable | 3t3cB-3qt4A:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rcy | MANDELATERACEMASE/MUCONATELACTONIZINGENZYME-LIKE PROTEIN (Roseovarius sp.TM1035) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 6 | ALA A 93VAL A 77ILE A 91GLY A 289ILE A 99VAL A 57 | None | 1.49A | 3t3cB-3rcyA:undetectable | 3t3cB-3rcyA:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ruc | WBGU (Plesiomonasshigelloides) |
PF01370(Epimerase) | 5 | VAL A 172ILE A 119GLY A 121ILE A 125ALA A 177 | None | 0.91A | 3t3cB-3rucA:undetectable | 3t3cB-3rucA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ssm | METHYLTRANSFERASE (Micromonosporagriseorubida) |
no annotation | 5 | ALA A 145ASP A 56GLY A 140ILE A 139VAL A 59 | None | 0.93A | 3t3cB-3ssmA:undetectable | 3t3cB-3ssmA:13.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t69 | PUTATIVE2-DEHYDRO-3-DEOXYGALACTONOKINASE (Sinorhizobiummeliloti) |
PF05035(DGOK) | 5 | ALA A 32GLY A 25PRO A 62ALA A 61VAL A 59 | None | 0.92A | 3t3cB-3t69A:undetectable | 3t3cB-3t69A:15.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 30GLY A 49ILE A 50PRO A 81 | 017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-4.6A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A) | 0.51A | 3t3cB-3ttpA:20.0 | 3t3cB-3ttpA:72.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 30ILE A 47PRO A 81VAL A 84 | 017 A 202 ( 2.5A)017 A 201 (-3.4A)017 A 201 ( 4.0A)017 A 202 (-3.6A)017 A 202 (-4.0A)None | 0.69A | 3t3cB-3u7sA:19.0 | 3t3cB-3u7sA:69.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25ALA A 28ILE A 47GLY A 49ILE A 50PRO A 81VAL A 84 | 017 A 202 ( 2.5A)017 A 201 (-3.4A)017 A 202 (-3.6A)017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A)None | 0.74A | 3t3cB-3u7sA:19.0 | 3t3cB-3u7sA:69.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ufx | SUCCINYL-COASYNTHETASE BETASUBUNIT (Thermusaquaticus) |
PF00549(Ligase_CoA)PF08442(ATP-grasp_2) | 5 | VAL B 289ILE B 309GLY B 311ILE B 313VAL B 288 | None | 1.02A | 3t3cB-3ufxB:undetectable | 3t3cB-3ufxB:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vpz | GLUCOKINASE (Pseudoalteromonassp. AS-131) |
PF02685(Glucokinase) | 5 | ALA A 120ILE A 316GLY A 320ALA A 154VAL A 144 | None | 1.04A | 3t3cB-3vpzA:undetectable | 3t3cB-3vpzA:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a7k | ALDOS-2-ULOSEDEHYDRATASE (Phanerochaetechrysosporium) |
no annotation | 5 | ALA A 100VAL A 170ILE A 111ALA A 193VAL A 168 | None | 0.97A | 3t3cB-4a7kA:undetectable | 3t3cB-4a7kA:8.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bv4 | PROTEIN TOLL,VARIABLE LYMPHOCYTERECEPTOR B CHIMERA (Drosophilamelanogaster;Eptatretusburgeri) |
PF11921(DUF3439)PF13855(LRR_8) | 5 | ASP R 273VAL R 271ILE R 274ALA R 244VAL R 247 | None | 0.95A | 3t3cB-4bv4R:undetectable | 3t3cB-4bv4R:10.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cgt | CYCLODEXTRINGLYCOSYLTRANSFERASE (Bacilluscirculans) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 5 | ASP A 319VAL A 355GLY A 225ALA A 357VAL A 321 | None | 0.92A | 3t3cB-4cgtA:undetectable | 3t3cB-4cgtA:8.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cgt | CYCLODEXTRINGLYCOSYLTRANSFERASE (Bacilluscirculans) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 5 | ASP A 319VAL A 355GLY A 225ILE A 134VAL A 321 | None | 1.02A | 3t3cB-4cgtA:undetectable | 3t3cB-4cgtA:8.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3w | ACID PHOSPHATASE (Francisellatularensis) |
PF00328(His_Phos_2) | 5 | ALA A 211ASP A 207GLY A 184ILE A 181ALA A 159 | None | 1.03A | 3t3cB-4e3wA:undetectable | 3t3cB-4e3wA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4emi | TODA (Pseudomonasputida) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 5 | ALA A 249ILE A 105ILE A 258ALA A 267VAL A 85 | None | 0.98A | 3t3cB-4emiA:undetectable | 3t3cB-4emiA:15.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fsf | PENICILLIN-BINDINGPROTEIN 3 (Pseudomonasaeruginosa) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | VAL A 165ILE A 65PRO A 156ALA A 157VAL A 161 | None | 0.85A | 3t3cB-4fsfA:undetectable | 3t3cB-4fsfA:11.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h16 | SHORT CHAIN ALCOHOLDEHYDROGENASE-RELATED DEHYDROGENASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | ALA A 237VAL A 81ILE A 233ALA A 12VAL A 79 | None | 1.01A | 3t3cB-4h16A:undetectable | 3t3cB-4h16A:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h6j | ARYL HYDROCARBONNUCLEAR TRANSLOCATOR (Homo sapiens) |
PF14598(PAS_11) | 5 | VAL B 416ILE B 369GLY B 371ILE B 396VAL B 415 | None | 0.95A | 3t3cB-4h6jB:undetectable | 3t3cB-4h6jB:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hdj | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMB (Pseudomonasaeruginosa) |
PF13360(PQQ_2) | 5 | GLY A 160ILE A 159PRO A 187ALA A 196VAL A 204 | None | 0.96A | 3t3cB-4hdjA:undetectable | 3t3cB-4hdjA:14.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hds | ARSB (Sporomusa ovata) |
PF02277(DBI_PRT) | 5 | ALA B 239ILE B 61GLY B 152ILE B 149VAL B 246 | None | 1.01A | 3t3cB-4hdsB:undetectable | 3t3cB-4hdsB:16.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i1p | MUCOSA-ASSOCIATEDLYMPHOID TISSUELYMPHOMATRANSLOCATIONPROTEIN 1 (Homo sapiens) |
PF00656(Peptidase_C14) | 5 | VAL A 632ILE A 614GLY A 603ALA A 630VAL A 686 | None | 1.04A | 3t3cB-4i1pA:undetectable | 3t3cB-4i1pA:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i84 | HEME/HEMOPEXIN-BINDING PROTEIN (Haemophilusinfluenzae) |
PF05860(Haemagg_act) | 5 | ALA A 164VAL A 149ILE A 143ILE A 205VAL A 170 | None | 1.01A | 3t3cB-4i84A:undetectable | 3t3cB-4i84A:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ilk | STARVATION SENSINGPROTEIN RSPB (Escherichiacoli) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ALA A 121GLY A 110ILE A 57ALA A 34VAL A 31 | None | 0.98A | 3t3cB-4ilkA:undetectable | 3t3cB-4ilkA:14.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcm | CYCLODEXTRINGLUCANOTRANSFERASE ([Bacillus]clarkii) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 5 | ASP A 309VAL A 345GLY A 216ALA A 347VAL A 311 | None | 1.02A | 3t3cB-4jcmA:undetectable | 3t3cB-4jcmA:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lc3 | PUTATIVEUDP-4-AMINO-4-DEOXY-L-ARABINOSE--OXOGLUTARATEAMINOTRANSFERASE (Burkholderiacenocepacia) |
PF01041(DegT_DnrJ_EryC1) | 5 | VAL A 179ILE A 172GLY A 164ALA A 196VAL A 198 | None | 0.98A | 3t3cB-4lc3A:undetectable | 3t3cB-4lc3A:15.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81 | RIT A 500 (-2.4A)RIT A 500 (-3.6A)RIT A 500 (-4.8A)NoneRIT A 500 ( 4.5A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A) | 0.54A | 3t3cB-4njvA:18.7 | 3t3cB-4njvA:74.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4phb | UNCHARACTERIZEDPROTEIN (Ruminiclostridiumthermocellum) |
PF14262(Cthe_2159) | 5 | VAL A 165ILE A 149GLY A 174ALA A 190VAL A 188 | None | 0.88A | 3t3cB-4phbA:undetectable | 3t3cB-4phbA:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q0c | VIRULENCE SENSORPROTEIN BVGS (Bordetellapertussis) |
PF00497(SBP_bac_3) | 5 | ASP A 46VAL A 47ILE A 95ALA A 263VAL A 49 | None | 1.04A | 3t3cB-4q0cA:undetectable | 3t3cB-4q0cA:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qcc | 2-DEHYDRO-3-DEOXY-6-PHOSPHOGALACTONATEALDOLASE,PEPTIDYL-PROLYLCIS-TRANS ISOMERASECHIMERA (Escherichiacoli) |
PF01081(Aldolase)PF01346(FKBP_N) | 5 | ALA A 60VAL A 25ILE A 52GLY A 63ALA A 11 | None | 1.05A | 3t3cB-4qccA:undetectable | 3t3cB-4qccA:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ras | OXIDOREDUCTASE,NAD-BINDING/IRON-SULFUR CLUSTER-BINDINGPROTEIN (Nitratireductorpacificus) |
PF12838(Fer4_7)PF13486(Dehalogenase) | 5 | ASP A 178ALA A 180VAL A 184GLY A 194ALA A 29 | None | 1.04A | 3t3cB-4rasA:undetectable | 3t3cB-4rasA:8.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u9p | UPF0264 PROTEINMJ1099 (Methanocaldococcusjannaschii) |
PF04476(4HFCP_synth) | 5 | VAL A 147ILE A 204GLY A 206ALA A 120VAL A 118 | None | 0.96A | 3t3cB-4u9pA:undetectable | 3t3cB-4u9pA:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y23 | GAMMA GLUTAMYLTRANSPEPTIDASE,GAMMA-GLUTAMYLTRANSPEPTIDASE (Bacilluslicheniformis) |
PF01019(G_glu_transpept) | 5 | VAL A 249GLY A 88ILE A 87ALA A 244VAL A 248 | None | 1.02A | 3t3cB-4y23A:undetectable | 3t3cB-4y23A:10.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zke | SUPERKILLER PROTEIN7 (Saccharomycescerevisiae) |
PF00009(GTP_EFTU) | 5 | VAL A 578ILE A 557GLY A 529ILE A 629VAL A 609 | VAL A 578 ( 0.6A)ILE A 557 ( 0.4A)GLY A 529 ( 0.0A)ILE A 629 ( 0.6A)VAL A 609 ( 0.6A) | 1.03A | 3t3cB-4zkeA:undetectable | 3t3cB-4zkeA:11.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dot | CARBAMOYL-PHOSPHATESYNTHASE [AMMONIA],MITOCHONDRIAL (Homo sapiens) |
PF00117(GATase)PF00988(CPSase_sm_chain)PF02142(MGS)PF02786(CPSase_L_D2)PF02787(CPSase_L_D3) | 5 | VAL A 231ILE A 293GLY A 296ILE A 299ALA A 222 | None | 1.02A | 3t3cB-5dotA:undetectable | 3t3cB-5dotA:5.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e4r | KETOL-ACIDREDUCTOISOMERASE (Ignisphaeraaggregans) |
PF01450(IlvC)PF07991(IlvN) | 5 | ALA A 165ILE A 10GLY A 171ALA A 149VAL A 151 | NoneNoneGOL A 506 ( 4.9A)NoneNone | 0.94A | 3t3cB-5e4rA:undetectable | 3t3cB-5e4rA:12.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i45 | GLYCOSYLTRANSFERASES GROUP 1FAMILY PROTEIN (Francisellatularensis) |
PF00534(Glycos_transf_1) | 5 | ALA A 276ILE A 285GLY A 261ALA A 267VAL A 274 | None | 1.04A | 3t3cB-5i45A:undetectable | 3t3cB-5i45A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5in2 | EXTRACELLULARSUPEROXIDE DISMUTASE[CU-ZN] (Onchocercavolvulus) |
PF00080(Sod_Cu) | 5 | VAL A 35ILE A 87GLY A 44ALA A 148VAL A 14 | None | 0.98A | 3t3cB-5in2A:undetectable | 3t3cB-5in2A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j1l | TOXR-ACTIVATED GENE(TAGE) (Helicobacterpylori) |
PF01551(Peptidase_M23) | 5 | ALA A 184VAL A 190ILE A 205GLY A 238VAL A 231 | None | 0.96A | 3t3cB-5j1lA:undetectable | 3t3cB-5j1lA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jo9 | RIBITOL2-DEHYDROGENASE (Bradyrhizobiumjaponicum) |
PF00106(adh_short) | 5 | ALA A 87VAL A 120ILE A 135GLY A 179VAL A 116 | None | 0.88A | 3t3cB-5jo9A:undetectable | 3t3cB-5jo9A:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lq3 | CMEB (Campylobacterjejuni) |
PF00873(ACR_tran) | 5 | ALA A 474VAL A 455GLY A 925ALA A 871VAL A 459 | None | 0.78A | 3t3cB-5lq3A:undetectable | 3t3cB-5lq3A:6.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lq3 | CMEB (Campylobacterjejuni) |
PF00873(ACR_tran) | 5 | ALA A 474VAL A 455ILE A 920ALA A 871VAL A 459 | None | 1.05A | 3t3cB-5lq3A:undetectable | 3t3cB-5lq3A:6.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4l | CERULOPLASMIN (Rattusnorvegicus) |
no annotation | 5 | ALA A 102VAL A 88ILE A 78GLY A 175ILE A 174 | None | 1.02A | 3t3cB-5n4lA:undetectable | 3t3cB-5n4lA:19.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ASP A 30VAL A 32ILE A 47GLY A 49ILE A 50PRO A 81 | None | 0.62A | 3t3cB-5t2zA:19.4 | 3t3cB-5t2zA:72.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vmk | BIFUNCTIONAL PROTEINGLMU (Acinetobacterbaumannii) |
PF00132(Hexapep)PF12804(NTP_transf_3)PF14602(Hexapep_2) | 5 | ALA A 358VAL A 347ILE A 352ALA A 327VAL A 345 | None | 1.04A | 3t3cB-5vmkA:undetectable | 3t3cB-5vmkA:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c5b | METHYLTRANSFERASE (Lysobacterantibioticus) |
no annotation | 5 | ASP A 180VAL A 178ILE A 192PRO A 174VAL A 243 | FMT A 502 (-2.6A)NoneNoneNoneNone | 0.85A | 3t3cB-6c5bA:undetectable | 3t3cB-6c5bA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MONOVALENT CATION/H+ANTIPORTER SUBUNIT EMONOVALENT CATION/H+ANTIPORTER SUBUNIT G (Pyrococcusfuriosus) |
no annotation | 5 | ALA A 84ILE A 88GLY A 90ILE A 92ALA C 24 | None | 1.03A | 3t3cB-6cfwA:undetectable | 3t3cB-6cfwA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g2j | NADH DEHYDROGENASE[UBIQUINONE] 1 ALPHASUBCOMPLEX SUBUNIT9, MITOCHONDRIALNADH DEHYDROGENASE[UBIQUINONE]IRON-SULFUR PROTEIN6, MITOCHONDRIAL (Mus musculus) |
no annotation | 5 | ASP R 30VAL R 26ILE P 46ILE P 81VAL R 29 | None | 0.96A | 3t3cB-6g2jR:undetectable | 3t3cB-6g2jR:24.00 |