SIMILAR PATTERNS OF AMINO ACIDS FOR 3T01_A_PPFA503_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a5i | PLASMINOGENACTIVATOR (Desmodusrotundus) |
PF00089(Trypsin) | 4 | THR A 229ASP A 102HIS A 57ILE A 213 | NoneNone0GJ A 245 (-2.7A)None | 0.98A | 3t01A-1a5iA:undetectable | 3t01A-1a5iA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cyg | CYCLODEXTRINGLUCANOTRANSFERASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 4 | PHE A 9THR A 10ASN A 5ASP A 315 | None | 1.07A | 3t01A-1cygA:undetectable | 3t01A-1cygA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d0n | HORSE PLASMAGELSOLIN (Equus caballus) |
PF00626(Gelsolin) | 4 | PHE A 130THR A 129ASP A 84HIS A 86 | None | 1.11A | 3t01A-1d0nA:undetectable | 3t01A-1d0nA:20.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ei6 | PHOSPHONOACETATEHYDROLASE (Pseudomonasfluorescens) |
PF01663(Phosphodiest) | 7 | PHE A 63THR A 64ASN A 85ASP A 202HIS A 206ILE A 278HIS A 368 | None ZN A 408 ( 2.5A)None ZN A 409 (-2.3A) ZN A 409 ( 3.3A)None ZN A 409 ( 3.4A) | 0.46A | 3t01A-1ei6A:62.6 | 3t01A-1ei6A:54.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1id2 | AMICYANIN (Paracoccusversutus) |
PF00127(Copper-bind) | 4 | PHE A 83THR A 43ASN A 84ILE A 4 | None | 1.05A | 3t01A-1id2A:undetectable | 3t01A-1id2A:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j5s | URONATE ISOMERASE (Thermotogamaritima) |
PF02614(UxaC) | 4 | THR A 151ASP A 231HIS A 290HIS A 30 | None | 0.93A | 3t01A-1j5sA:undetectable | 3t01A-1j5sA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pfx | FACTOR IXA (Sus scrofa) |
PF00089(Trypsin) | 4 | THR C 229ASP C 102HIS C 57ILE C 213 | NoneNone0G6 C 301 (-2.5A)None | 0.98A | 3t01A-1pfxC:undetectable | 3t01A-1pfxC:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1svv | THREONINE ALDOLASE (Leishmaniamajor) |
PF01212(Beta_elim_lyase) | 4 | THR A 40ASP A 37HIS A 50HIS A 42 | UNL A 401 ( 4.2A)UNL A 401 (-1.9A)UNL A 401 (-3.4A)UNL A 401 (-3.0A) | 1.06A | 3t01A-1svvA:undetectable | 3t01A-1svvA:25.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y13 | 6-PYRUVOYLTETRAHYDROPTERINSYNTHASE (Plasmodiumfalciparum) |
PF01242(PTPS) | 4 | THR A 127HIS A 41ILE A 31HIS A 29 | BIO A 175 ( 4.7A) ZN A 174 ( 3.3A)BIO A 175 (-4.2A) ZN A 174 ( 3.5A) | 1.08A | 3t01A-1y13A:undetectable | 3t01A-1y13A:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y3t | HYPOTHETICAL PROTEINYXAG (Bacillussubtilis) |
PF07883(Cupin_2) | 4 | THR A 118HIS A 62ILE A 97HIS A 64 | None FE A 401 (-3.6A)None FE A 401 (-3.3A) | 1.04A | 3t01A-1y3tA:undetectable | 3t01A-1y3tA:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2anu | HYPOTHETICAL PROTEINTM0559 (Thermotogamaritima) |
no annotation | 4 | ASN A 101ASP A 193HIS A 195HIS A 15 | None ZN A 605 (-2.4A) ZN A 505 (-3.4A) ZN A 405 (-3.4A) | 1.09A | 3t01A-2anuA:undetectable | 3t01A-2anuA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cja | SERYL-TRNASYNTHETASE (Methanosarcinabarkeri) |
no annotation | 4 | THR A 414ASN A 439HIS A 373ILE A 438 | None | 1.09A | 3t01A-2cjaA:undetectable | 3t01A-2cjaA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cw2 | SUPEROXIDE DISMUTASE1 (Perkinsusmarinus) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 4 | PHE A 83ASN A 160HIS A 166HIS A 31 | NoneNone FE A 402 (-3.1A) FE A 402 (-3.1A) | 1.08A | 3t01A-2cw2A:undetectable | 3t01A-2cw2A:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6k | METAL-DEPENDENTHYDROLASE (Lactobacillusplantarum) |
PF04909(Amidohydro_2) | 4 | ASN A 156ASP A 266HIS A 7HIS A 205 | None MN A 402 (-2.7A) MN A 402 (-3.3A)None | 1.03A | 3t01A-2f6kA:undetectable | 3t01A-2f6kA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gsn | PHOSPHODIESTERASE-NUCLEOTIDEPYROPHOSPHATASE (Xanthomonascitri) |
PF01663(Phosphodiest) | 4 | THR A 90ASP A 210HIS A 214HIS A 363 | ZN A1000 (-2.4A) ZN A1001 (-2.0A) ZN A1001 (-3.2A) ZN A1001 (-3.3A) | 0.53A | 3t01A-2gsnA:28.2 | 3t01A-2gsnA:25.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iuw | ALKYLATED REPAIRPROTEIN ALKB HOMOLOG3 (Homo sapiens) |
PF13532(2OG-FeII_Oxy_2) | 4 | ASN A 271ASP A 193HIS A 191HIS A 257 | AKG A 700 (-3.4A) FE A 500 ( 2.6A) FE A 500 ( 3.3A) FE A 500 ( 3.3A) | 1.00A | 3t01A-2iuwA:undetectable | 3t01A-2iuwA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogj | DIHYDROOROTASE (Agrobacteriumfabrum) |
PF01979(Amidohydro_1) | 4 | ASN A 144ASP A 291HIS A 77HIS A 231 | None ZN A 418 (-2.5A)KCX A 175 (-3.3A) ZN A 419 (-3.6A) | 0.94A | 3t01A-2ogjA:undetectable | 3t01A-2ogjA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogj | DIHYDROOROTASE (Agrobacteriumfabrum) |
PF01979(Amidohydro_1) | 4 | ASN A 144ASP A 291ILE A 87HIS A 79 | None ZN A 418 (-2.5A)None ZN A 418 (-3.4A) | 0.92A | 3t01A-2ogjA:undetectable | 3t01A-2ogjA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pq6 | UDP-GLUCURONOSYL/UDP-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 4 | PHE A 66ASN A 67ILE A 39HIS A 33 | None | 0.93A | 3t01A-2pq6A:undetectable | 3t01A-2pq6A:23.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q01 | URONATE ISOMERASE (Caulobactervibrioides) |
PF02614(UxaC) | 4 | THR A 169ASP A 249HIS A 307HIS A 39 | None | 0.93A | 3t01A-2q01A:undetectable | 3t01A-2q01A:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9m | POLYMERASE X (Deinococcusradiodurans) |
PF14520(HHH_5)PF14716(HHH_8) | 4 | ASN A 491ASP A 339HIS A 364HIS A 334 | None ZN A1565 (-2.1A) ZN A1565 (-3.2A) ZN A1566 (-3.5A) | 1.06A | 3t01A-2w9mA:undetectable | 3t01A-2w9mA:25.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y7r | LYSR-TYPE REGULATORYPROTEIN (Burkholderiasp. DNT) |
PF03466(LysR_substrate) | 4 | PHE A 167HIS A 206ILE A 273HIS A 169 | None | 1.13A | 3t01A-2y7rA:undetectable | 3t01A-2y7rA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zm2 | 6-AMINOHEXANOATE-DIMER HYDROLASE (Flavobacteriumsp.) |
PF00144(Beta-lactamase) | 4 | THR A 197ASP A 221HIS A 266HIS A 180 | NoneNoneMES A 504 (-4.0A)MES A 504 (-4.2A) | 0.96A | 3t01A-2zm2A:undetectable | 3t01A-2zm2A:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3am3 | ENOYL-ACP REDUCTASE (Plasmodiumfalciparum) |
PF13561(adh_short_C2) | 4 | PHE A 368THR A 367ASN A 324ILE A 323 | TCL A 802 (-4.8A)NoneNoneNone | 0.97A | 3t01A-3am3A:undetectable | 3t01A-3am3A:19.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqc | COMPONENT A OFHEXAPRENYLDIPHOSPHATE SYNTHASECOMPONENT B OFHEXAPRENYLDIPHOSPHATE SYNTHASE (Micrococcusluteus) |
PF00348(polyprenyl_synt)no annotation | 4 | ASN A 103ASP A 73ILE B 109HIS B 83 | None2DE B 329 (-3.4A)None2DE B 329 ( 4.5A) | 1.04A | 3t01A-3aqcA:undetectable | 3t01A-3aqcA:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b2z | ADAMTS-4 (Homo sapiens) |
PF01421(Reprolysin) | 4 | ASN A 373ASP A 328HIS A 365HIS A 361 | None ZN A 1 (-1.9A) ZN A 1 (-3.3A) ZN A 1 (-3.0A) | 0.93A | 3t01A-3b2zA:undetectable | 3t01A-3b2zA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bb6 | UNCHARACTERIZEDPROTEIN YEAR (Escherichiacoli) |
PF09313(DUF1971) | 4 | ASP A 32HIS A 30ILE A 85HIS A 83 | ZN A 128 (-2.9A) ZN A 128 (-4.1A)None ZN A 128 (-3.8A) | 1.08A | 3t01A-3bb6A:undetectable | 3t01A-3bb6A:16.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3btz | ALPHA-KETOGLUTARATE-DEPENDENTDIOXYGENASE ALKBHOMOLOG 2 (Homo sapiens) |
PF13532(2OG-FeII_Oxy_2) | 4 | ASN A 159ASP A 173ILE A 168HIS A 236 | None | 0.96A | 3t01A-3btzA:undetectable | 3t01A-3btzA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3btz | ALPHA-KETOGLUTARATE-DEPENDENTDIOXYGENASE ALKBHOMOLOG 2 (Homo sapiens) |
PF13532(2OG-FeII_Oxy_2) | 4 | ASN A 250ASP A 173HIS A 171HIS A 236 | None | 0.97A | 3t01A-3btzA:undetectable | 3t01A-3btzA:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dy5 | ALLENE OXIDESYNTHASE-LIPOXYGENASE PROTEIN (Plexaurahomomalla) |
PF00305(Lipoxygenase)PF01477(PLAT) | 4 | THR A1064HIS A 757ILE A1066HIS A 762 | NoneFE2 A1099 (-3.1A)NoneFE2 A1099 (-3.4A) | 1.04A | 3t01A-3dy5A:undetectable | 3t01A-3dy5A:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e38 | TWO-DOMAIN PROTEINCONTAINING PREDICTEDPHP-LIKEMETAL-DEPENDENTPHOSPHOESTERASE (Bacteroidesvulgatus) |
PF16392(DUF5001) | 4 | ASN A 190ASP A 51HIS A 76HIS A 46 | None ZN A 3 ( 2.0A) ZN A 3 ( 3.3A) ZN A 2 ( 3.2A) | 1.10A | 3t01A-3e38A:undetectable | 3t01A-3e38A:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqn | GLUCAN1,3-BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF12708(Pectate_lyase_3) | 4 | ASN A 155ASP A 488ILE A 181HIS A 383 | None ZN A 757 (-4.6A)None ZN A 757 ( 3.4A) | 0.98A | 3t01A-3eqnA:undetectable | 3t01A-3eqnA:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 156ASN A 190ASP A 130HIS A 52 | NAD A 438 (-3.8A)NAD A 438 (-3.4A)NoneADN A 439 ( 4.7A) | 1.10A | 3t01A-3h9uA:undetectable | 3t01A-3h9uA:25.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iac | GLUCURONATEISOMERASE (Salmonellaenterica) |
PF02614(UxaC) | 4 | THR A 158ASP A 239HIS A 299HIS A 33 | None | 0.95A | 3t01A-3iacA:undetectable | 3t01A-3iacA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 4 | THR A 251ASN A 247ASP A 458HIS A 459 | None | 1.10A | 3t01A-3kjrA:undetectable | 3t01A-3kjrA:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kl7 | PUTATIVEMETAL-DEPENDENTHYDROLASE (Parabacteroidesdistasonis) |
PF13483(Lactamase_B_3) | 4 | ASN A 137ASP A 83HIS A 84HIS A 215 | None ZN A 303 (-2.7A) ZN A 303 (-3.4A) ZN A 303 (-3.3A) | 0.78A | 3t01A-3kl7A:undetectable | 3t01A-3kl7A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l5a | NADH/FLAVINOXIDOREDUCTASE/NADHOXIDASE (Staphylococcusaureus) |
PF00724(Oxidored_FMN) | 4 | ASP A 190HIS A 191ILE A 145HIS A 142 | None | 1.13A | 3t01A-3l5aA:undetectable | 3t01A-3l5aA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm4 | CATECHOL2,3-DIOXYGENASE (Rhodococcusjostii) |
PF00903(Glyoxalase) | 4 | PHE A 270ASN A 228HIS A 217HIS A 155 | NoneNone FE A 400 ( 3.4A) FE A 400 ( 3.5A) | 1.13A | 3t01A-3lm4A:undetectable | 3t01A-3lm4A:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lxu | TRIPEPTIDYL-PEPTIDASE 2 (Drosophilamelanogaster) |
PF00082(Peptidase_S8)PF12580(TPPII)PF12583(TPPII_N) | 4 | THR X1273HIS X1297ILE X1268HIS X1293 | None | 1.08A | 3t01A-3lxuX:2.6 | 3t01A-3lxuX:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m7p | FN1 PROTEIN (Homo sapiens) |
PF00039(fn1)PF00040(fn2) | 4 | THR A 507ASN A 501ASP A 522HIS A 539 | NoneNoneNone ZN A 955 (-4.9A) | 1.01A | 3t01A-3m7pA:undetectable | 3t01A-3m7pA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mg3 | ORANGECAROTENOID-BINDINGPROTEIN (Synechocystissp. PCC 6803) |
PF02136(NTF2)PF09150(Carot_N) | 4 | PHE A 12THR A 15ASP A 304ILE A 11 | None | 1.08A | 3t01A-3mg3A:undetectable | 3t01A-3mg3A:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3od2 | NICKEL-RESPONSIVEREGULATORY PROTEIN (Escherichiacoli) |
PF01402(RHH_1)PF08753(NikR_C) | 4 | THR A 74ASP A 114HIS A 110HIS A 78 | None NI A 137 (-3.1A) NI A 137 (-3.3A) NI A 137 (-3.3A) | 1.07A | 3t01A-3od2A:3.1 | 3t01A-3od2A:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3q | ALKALINE PHOSPHATASE (Sphingomonassp. BSAR-1) |
PF01663(Phosphodiest) | 4 | THR A 89ASP A 300HIS A 304HIS A 491 | ZN A1559 ( 2.6A) ZN A1561 ( 2.1A) ZN A1561 ( 3.2A) ZN A1561 ( 3.2A) | 0.40A | 3t01A-3q3qA:25.3 | 3t01A-3q3qA:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3re3 | 2-C-METHYL-D-ERYTHRITOL2,4-CYCLODIPHOSPHATESYNTHASE (Francisellatularensis) |
PF02542(YgbB) | 4 | PHE A 14THR A 15ASP A 39HIS A 12 | None | 0.84A | 3t01A-3re3A:undetectable | 3t01A-3re3A:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rpc | POSSIBLEMETAL-DEPENDENTHYDROLASE (Veillonellaparvula) |
PF12706(Lactamase_B_2) | 4 | ASP A 73HIS A 74ILE A 201HIS A 223 | ZN A 302 (-2.8A) ZN A 302 (-3.4A)None ZN A 302 (-3.5A) | 0.81A | 3t01A-3rpcA:undetectable | 3t01A-3rpcA:21.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t02 | PHOSPHONOACETATEHYDROLASE (Sinorhizobiummeliloti) |
PF01663(Phosphodiest) | 4 | PHE A 67ASN A 89ASP A 29HIS A 251 | NoneNone ZN A 501 ( 2.2A) ZN A 501 ( 3.0A) | 0.85A | 3t01A-3t02A:72.6 | 3t01A-3t02A:99.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t02 | PHOSPHONOACETATEHYDROLASE (Sinorhizobiummeliloti) |
PF01663(Phosphodiest) | 6 | PHE A 67ASN A 89ASP A 211HIS A 215ILE A 287HIS A 377 | NoneNone ZN A 502 (-2.2A) ZN A 502 ( 3.3A)None ZN A 502 ( 3.2A) | 0.23A | 3t01A-3t02A:72.6 | 3t01A-3t02A:99.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t3o | METAL DEPENDENTHYDROLASE (Thermusthermophilus) |
PF07521(RMMBL)PF12706(Lactamase_B_2) | 4 | ASP A 172HIS A 376ILE A 21HIS A 398 | ZN A 600 (-2.4A)NoneNone ZN A 600 (-3.6A) | 1.11A | 3t01A-3t3oA:2.2 | 3t01A-3t3oA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tht | ALKYLATED DNA REPAIRPROTEIN ALKB HOMOLOG8 (Homo sapiens) |
PF00076(RRM_1)PF13532(2OG-FeII_Oxy_2) | 4 | ASN A 227ASP A 240ILE A 235HIS A 292 | AKG A 403 (-3.2A) MN A 402 ( 2.6A)AKG A 403 (-4.4A) MN A 402 ( 3.6A) | 1.03A | 3t01A-3thtA:undetectable | 3t01A-3thtA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujp | MN TRANSPORTERSUBUNIT (Synechocystissp. PCC 6803) |
PF01297(ZnuA) | 4 | ASN A 152ASP A 295ILE A 240HIS A 89 | None MN A 1 (-2.1A)None MN A 1 (-3.3A) | 1.06A | 3t01A-3ujpA:undetectable | 3t01A-3ujpA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ukf | UDP-GALACTOPYRANOSEMUTASE (Aspergillusfumigatus) |
PF13450(NAD_binding_8) | 4 | ASN A 207ASP A 459HIS A 460HIS A 68 | GDU A 802 (-3.3A)NoneNoneNone | 0.89A | 3t01A-3ukfA:undetectable | 3t01A-3ukfA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wl4 | UNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF02585(PIG-L) | 4 | THR A 68ASP A 150HIS A 148HIS A 40 | NoneNoneTAM A 309 (-4.8A) CD A 301 ( 3.4A) | 1.12A | 3t01A-3wl4A:undetectable | 3t01A-3wl4A:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zq4 | RIBONUCLEASE J 1 (Bacillussubtilis) |
PF00753(Lactamase_B)PF07521(RMMBL) | 4 | ASP A 164HIS A 368ILE A 20HIS A 390 | ZN A1556 ( 2.7A)NoneNone ZN A1556 (-3.4A) | 1.03A | 3t01A-3zq4A:undetectable | 3t01A-3zq4A:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aui | PORIN (PORB) (Neisseriagonorrhoeae) |
PF00267(Porin_1) | 4 | PHE A 249THR A 261ASP A 263HIS A 247 | None | 1.08A | 3t01A-4auiA:undetectable | 3t01A-4auiA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b56 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 1 (Mus musculus) |
PF01033(Somatomedin_B)PF01223(Endonuclease_NS)PF01663(Phosphodiest) | 4 | THR A 238ASP A 358HIS A 362HIS A 517 | ZN A1002 ( 2.3A) ZN A1001 (-2.1A) ZN A1001 ( 3.2A) ZN A1001 ( 3.3A) | 0.44A | 3t01A-4b56A:26.6 | 3t01A-4b56A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bzi | SEC23P (Saccharomycescerevisiae) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 5 | PHE A 608ASP A 363HIS A 420ILE A 612HIS A 611 | None | 1.38A | 3t01A-4bziA:undetectable | 3t01A-4bziA:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cnk | L-AMINO ACID OXIDASE (Streptococcuscristatus) |
PF03486(HI0933_like) | 4 | PHE A 373THR A 370ASN A 51HIS A 225 | NoneMEU A1393 (-4.0A)FAD A1392 (-4.2A)None | 1.08A | 3t01A-4cnkA:undetectable | 3t01A-4cnkA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gxw | ADENOSINE DEAMINASE (Burkholderiaambifaria) |
PF00962(A_deaminase) | 4 | ASN A 117ASP A 300HIS A 34HIS A 215 | None ZN A 401 (-2.6A) ZN A 401 (-3.4A) ZN A 401 (-3.4A) | 1.07A | 3t01A-4gxwA:undetectable | 3t01A-4gxwA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hfs | UNCHARACTERIZEDPROTEIN YNCM (Bacillussubtilis) |
PF15493(YrpD) | 4 | PHE A 215THR A 245ASN A 216ILE A 72 | None | 1.11A | 3t01A-4hfsA:undetectable | 3t01A-4hfsA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lr2 | BIS(5'-ADENOSYL)-TRIPHOSPHATASE ENPP4 (Homo sapiens) |
PF01663(Phosphodiest) | 4 | THR A 70ASP A 189HIS A 193HIS A 336 | ZN A 505 ( 2.4A) ZN A 506 ( 2.1A) ZN A 506 ( 3.3A) ZN A 506 ( 3.3A) | 0.41A | 3t01A-4lr2A:27.5 | 3t01A-4lr2A:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m8d | PUTATIVEUNCHARACTERIZEDPROTEIN (Labrenziaaggregata) |
PF04199(Cyclase) | 4 | THR A 197ASP A 79HIS A 77ILE A 195 | None MN A 301 ( 2.5A) MN A 301 ( 3.3A)None | 1.11A | 3t01A-4m8dA:undetectable | 3t01A-4m8dA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mhu | ECTOINE HYDROXYLASE (Sphingopyxisalaskensis) |
PF05721(PhyH) | 4 | ASN A 258ASP A 146HIS A 144HIS A 245 | None FE A 401 (-2.6A) FE A 401 (-3.7A) FE A 401 (-3.9A) | 0.88A | 3t01A-4mhuA:undetectable | 3t01A-4mhuA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mvc | CHOLINE-PHOSPHATECYTIDYLYLTRANSFERASEA (Rattusnorvegicus) |
PF01467(CTP_transf_like) | 4 | PHE A 124THR A 125ASP A 115HIS A 119 | None | 0.94A | 3t01A-4mvcA:undetectable | 3t01A-4mvcA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nmi | ECTD (Virgibacillussalexigens) |
PF05721(PhyH) | 4 | ASN A 261ASP A 148HIS A 146HIS A 248 | None | 1.01A | 3t01A-4nmiA:undetectable | 3t01A-4nmiA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4npl | RNA DEMETHYLASEALKBH5 (Danio rerio) |
PF13532(2OG-FeII_Oxy_2) | 4 | ASN A 124ASP A 137ILE A 132HIS A 197 | AKG A 301 (-3.1A) MN A 300 (-2.8A)AKG A 301 (-4.3A) MN A 300 ( 3.4A) | 1.03A | 3t01A-4nplA:undetectable | 3t01A-4nplA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nrq | RNA DEMETHYLASEALKBH5 (Homo sapiens) |
PF13532(2OG-FeII_Oxy_2) | 4 | ASN A 193ASP A 206ILE A 201HIS A 266 | PD2 A 301 (-3.3A) MN A 302 ( 2.7A)PD2 A 301 (-4.8A) MN A 302 ( 3.3A) | 1.06A | 3t01A-4nrqA:undetectable | 3t01A-4nrqA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rv2 | UPF0336 PROTEINMSMEG_1340/MSMEI_1302 (Mycolicibacteriumsmegmatis) |
PF13452(MaoC_dehydrat_N) | 4 | PHE A 59THR A 58ILE A 62HIS A 28 | None | 0.87A | 3t01A-4rv2A:undetectable | 3t01A-4rv2A:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xwt | DR2417 (Deinococcusradiodurans) |
PF00753(Lactamase_B)PF07521(RMMBL) | 4 | ASP A 175HIS A 381ILE A 30HIS A 403 | ZN A 602 ( 2.5A)U5P A 606 (-3.9A)None ZN A 602 (-3.2A) | 1.02A | 3t01A-4xwtA:2.2 | 3t01A-4xwtA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zg7 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 2 (Homo sapiens) |
PF01033(Somatomedin_B)PF01223(Endonuclease_NS)PF01663(Phosphodiest) | 4 | THR A 210ASP A 312HIS A 316HIS A 475 | ZN A 904 ( 2.6A) ZN A 903 ( 2.0A) ZN A 903 ( 3.2A) ZN A 903 ( 3.3A) | 0.39A | 3t01A-4zg7A:24.0 | 3t01A-4zg7A:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0t | RIBONUCLEASE J (Streptomycescoelicolor) |
PF00753(Lactamase_B)PF07521(RMMBL) | 4 | ASP A 173HIS A 377ILE A 30HIS A 399 | ZN A1457 ( 2.7A) G E 1 ( 3.9A) C E 0 ( 3.6A) ZN A1457 (-3.5A) | 1.01A | 3t01A-5a0tA:undetectable | 3t01A-5a0tA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp3 | MYCOCEROSIC ACIDSYNTHASE-LIKEPOLYKETIDE SYNTHASE (Mycolicibacteriumsmegmatis) |
PF14765(PS-DH) | 4 | ASP A1100HIS A 934ILE A1053HIS A1055 | NoneEDO A1202 (-4.3A)NoneNone | 1.05A | 3t01A-5bp3A:undetectable | 3t01A-5bp3A:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ebb | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3A (Homo sapiens) |
PF00149(Metallophos) | 4 | ASN A 211ASP A 45HIS A 295HIS A 47 | None ZN A 702 ( 3.0A) ZN A 702 ( 3.4A) ZN A 702 ( 3.4A) | 1.03A | 3t01A-5ebbA:undetectable | 3t01A-5ebbA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fca | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3A (Mus musculus) |
PF00149(Metallophos) | 4 | ASN A 208ASP A 42HIS A 292HIS A 44 | None ZN A 501 (-3.1A) ZN A 501 (-3.4A) ZN A 501 (-3.3A) | 1.00A | 3t01A-5fcaA:undetectable | 3t01A-5fcaA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fca | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3A (Mus musculus) |
PF00149(Metallophos) | 5 | THR A 317ASN A 328ASP A 79HIS A 111HIS A 44 | NoneNoneGOL A 518 ( 4.9A)GOL A 518 (-2.7A) ZN A 501 (-3.3A) | 1.33A | 3t01A-5fcaA:undetectable | 3t01A-5fcaA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gz4 | SNAKE VENOMPHOSPHODIESTERASE(PDE) (Naja atra) |
PF01033(Somatomedin_B)PF01223(Endonuclease_NS)PF01663(Phosphodiest) | 4 | THR A 185ASN A 206ASP A 305HIS A 353 | ZN A 902 (-2.7A)None ZN A 901 (-2.2A) ZN A 902 (-3.0A) | 0.95A | 3t01A-5gz4A:27.0 | 3t01A-5gz4A:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gz4 | SNAKE VENOMPHOSPHODIESTERASE(PDE) (Naja atra) |
PF01033(Somatomedin_B)PF01223(Endonuclease_NS)PF01663(Phosphodiest) | 4 | THR A 185ASP A 305HIS A 309HIS A 462 | ZN A 902 (-2.7A) ZN A 901 (-2.2A) ZN A 901 (-3.1A) ZN A 901 (-3.2A) | 0.37A | 3t01A-5gz4A:27.0 | 3t01A-5gz4A:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hgr | ORANGE CAROTENOIDPROTEIN (OCP) (Nostoc sp. PCC7120) |
PF02136(NTF2)PF09150(Carot_N) | 4 | PHE A 12THR A 15ASP A 306ILE A 11 | None | 1.08A | 3t01A-5hgrA:undetectable | 3t01A-5hgrA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hqn | SPHINGOMYELINPHOSPHODIESTERASE (Mus musculus) |
PF00149(Metallophos) | 4 | ASN A 323ASP A 204HIS A 457HIS A 206 | None ZN A 701 (-3.0A) ZN A 701 ( 3.1A) ZN A 701 ( 3.3A) | 1.01A | 3t01A-5hqnA:undetectable | 3t01A-5hqnA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i35 | ATYPICAL KINASEADCK3, MITOCHONDRIAL (Homo sapiens) |
PF03109(ABC1) | 4 | THR A 606HIS A 559ILE A 525HIS A 610 | None | 0.82A | 3t01A-5i35A:undetectable | 3t01A-5i35A:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i85 | SPHINGOMYELINPHOSPHODIESTERASE (Homo sapiens) |
PF00149(Metallophos) | 4 | ASN A 325ASP A 206HIS A 459HIS A 208 | None ZN A 715 ( 3.1A) ZN A 715 ( 3.3A) ZN A 715 ( 3.4A) | 0.98A | 3t01A-5i85A:undetectable | 3t01A-5i85A:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikk | HISTONE DEACETYLASECLR3 (Schizosaccharomycespombe) |
PF00850(Hist_deacetyl)PF09757(Arb2) | 4 | ASP A 234HIS A 195ILE A 334HIS A 236 | ZN A 701 ( 1.7A) ZN A 701 (-2.9A)None ZN A 701 ( 3.1A) | 1.03A | 3t01A-5ikkA:undetectable | 3t01A-5ikkA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kar | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3B (Mus musculus) |
PF00149(Metallophos) | 4 | ASN A 141ASP A 28HIS A 279HIS A 30 | None ZN A 502 (-3.0A)GOL A 515 ( 2.6A) ZN A 502 (-3.3A) | 0.93A | 3t01A-5karA:undetectable | 3t01A-5karA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kar | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3B (Mus musculus) |
PF00149(Metallophos) | 4 | ASN A 195ASP A 28HIS A 279HIS A 30 | None ZN A 502 (-3.0A)GOL A 515 ( 2.6A) ZN A 502 (-3.3A) | 1.01A | 3t01A-5karA:undetectable | 3t01A-5karA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kku | POLYKETIDE SYNTHASETYPE I (Bacillusamyloliquefaciens) |
PF14765(PS-DH) | 4 | THR A 201ASP A 198HIS A 25ILE A 220 | None | 1.10A | 3t01A-5kkuA:undetectable | 3t01A-5kkuA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nmp | ISATIN HYDROLASE (Ralstoniasolanacearum) |
no annotation | 4 | THR A 199ASP A 80HIS A 78ILE A 197 | None MN A 301 ( 2.4A) MN A 301 (-3.3A)None | 0.92A | 3t01A-5nmpA:undetectable | 3t01A-5nmpA:10.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5osh | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 29 (Homo sapiens) |
no annotation | 4 | PHE A 63ASP A 8HIS A 117HIS A 10 | None | 0.81A | 3t01A-5oshA:undetectable | 3t01A-5oshA:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5udy | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 7 (Homo sapiens) |
PF01663(Phosphodiest) | 4 | THR A 75ASP A 199HIS A 203HIS A 353 | ZN A 501 (-2.6A) ZN A 502 (-2.3A) ZN A 502 (-3.3A) ZN A 502 (-3.3A) | 0.39A | 3t01A-5udyA:29.0 | 3t01A-5udyA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ui2 | ORANGECAROTENOID-BINDINGPROTEIN (Arthrospiramaxima) |
PF02136(NTF2)PF09150(Carot_N) | 4 | PHE A 12THR A 15ASP A 306ILE A 11 | None | 1.11A | 3t01A-5ui2A:undetectable | 3t01A-5ui2A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5utu | ADENOSYLHOMOCYSTEINASE (Cryptosporidiumparvum) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | THR A 212ASN A 246ASP A 137HIS A 53 | NAD A 501 ( 4.1A)NAD A 501 (-3.5A)SAH A 502 (-3.4A)SAH A 502 (-4.0A) | 1.00A | 3t01A-5utuA:undetectable | 3t01A-5utuA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uyg | PERIPLASMIC CHELATEDIRON-BINDING PROTEINYFEA (Yersinia pestis) |
PF01297(ZnuA) | 4 | ASN A 139ASP A 282ILE A 227HIS A 76 | None ZN A 401 (-2.1A)None ZN A 401 (-3.3A) | 0.98A | 3t01A-5uygA:undetectable | 3t01A-5uygA:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vem | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 5 (Homo sapiens) |
PF01663(Phosphodiest) | 4 | THR A 72ASP A 191HIS A 195HIS A 339 | ZN A 501 (-2.4A) ZN A 502 (-2.0A) ZN A 502 (-3.2A) ZN A 502 (-3.2A) | 0.32A | 3t01A-5vemA:27.5 | 3t01A-5vemA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1u | CARBOXYLIC ESTERHYDROLASE (Culexquinquefasciatus) |
PF00135(COesterase) | 5 | PHE A 506THR A 502ASN A 499ILE A 402HIS A 399 | None | 1.32A | 3t01A-5w1uA:undetectable | 3t01A-5w1uA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xoi | OXIDOREDUCTASE,2OG-FE OXYGENASEFAMILY PROTEIN,PUTATIVE, EXPRESSED (Oryza sativa) |
no annotation | 4 | ASN A 365ASP A 281HIS A 279HIS A 339 | SIN A 401 (-3.5A) MN A 402 (-2.5A) MN A 402 ( 3.4A) MN A 402 ( 3.4A) | 1.12A | 3t01A-5xoiA:undetectable | 3t01A-5xoiA:10.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yjp | HUMAN CHYMASE (Homo sapiens) |
no annotation | 4 | PHE A 228THR A 229ASP A 102HIS A 57 | NoneNone8W6 A 304 (-3.9A)8W6 A 304 (-3.7A) | 0.89A | 3t01A-5yjpA:undetectable | 3t01A-5yjpA:10.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bmm | HUMAN DHHC20PALMITOYLTRANSFERASE (Homo sapiens) |
no annotation | 4 | PHE A 74THR A 75ASN A 161ILE A 73 | None | 1.01A | 3t01A-6bmmA:undetectable | 3t01A-6bmmA:10.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bms | PALMITOYLTRANSFERASE (Danio rerio) |
no annotation | 4 | PHE A 64THR A 65ASN A 148ILE A 63 | None | 0.98A | 3t01A-6bmsA:undetectable | 3t01A-6bmsA:11.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6brm | PUTATIVEMETAL-DEPENDENTISOTHIOCYANATEHYDROLASE SAXA (Pectobacteriumcarotovorum) |
no annotation | 4 | ASP A 71HIS A 72ILE A 199HIS A 221 | ZN A 302 (-2.7A) ZN A 302 (-3.3A)None ZN A 302 (-3.4A) | 0.82A | 3t01A-6brmA:undetectable | 3t01A-6brmA:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c01 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 3 (Homo sapiens) |
no annotation | 4 | THR A 205ASP A 325HIS A 329HIS A 483 | ZN A 902 (-2.5A) ZN A 901 ( 2.1A) ZN A 901 ( 3.3A) ZN A 901 ( 3.3A) | 0.38A | 3t01A-6c01A:25.6 | 3t01A-6c01A:9.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dch | SCOE PROTEIN (Streptomycescoeruleorubidus) |
no annotation | 4 | THR A 312ASP A 134HIS A 295ILE A 147 | None ZN A 403 (-2.4A) ZN A 403 ( 3.2A)None | 1.10A | 3t01A-6dchA:undetectable | 3t01A-6dchA:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f2t | - (-) |
no annotation | 4 | THR A 206ASP A 326HIS A 330HIS A 483 | ZN A1002 ( 2.5A) ZN A1003 ( 2.1A) ZN A1003 (-3.2A) ZN A1003 ( 3.1A) | 0.48A | 3t01A-6f2tA:26.5 | 3t01A-6f2tA:undetectable |