SIMILAR PATTERNS OF AMINO ACIDS FOR 3SXR_A_1N1A1_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1k2p | TYROSINE-PROTEINKINASE BTK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | VAL A 416ALA A 428VAL A 458ILE A 472TYR A 476GLY A 480LEU A 528 | None | 0.51A | 3sxrA-1k2pA:32.7 | 3sxrA-1k2pA:65.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 9 | VAL A 209ALA A 220MET A 240VAL A 249ILE A 264THR A 266TYR A 268GLY A 272LEU A 321 | None | 0.52A | 3sxrA-1k9aA:32.1 | 3sxrA-1k9aA:29.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 9 | LEU A 267VAL A 275ALA A 288MET A 309VAL A 318ILE A 332THR A 334GLY A 340LEU A 389 | P16 A 2 ( 4.2A)P16 A 2 (-4.5A)P16 A 2 (-3.4A)P16 A 2 (-3.3A)P16 A 2 ( 4.7A)P16 A 2 (-4.1A)P16 A 2 (-3.7A)P16 A 2 (-3.4A)P16 A 2 (-4.4A) | 0.62A | 3sxrA-1opkA:33.1 | 3sxrA-1opkA:25.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 616VAL A 624ALA A 642VAL A 675TYR A 693GLY A 697LEU A 818 | None | 0.52A | 3sxrA-1rjbA:29.1 | 3sxrA-1rjbA:36.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s9i | DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 78VAL A 86ALA A 99VAL A 131ILE A 145GLY A 153LEU A 201 | ATP A 535 (-3.9A)ATP A 535 (-4.1A)ATP A 535 (-3.6A)5EA A1001 (-4.5A)5EA A1001 ( 3.7A)ATP A 535 ( 4.7A)ATP A 535 (-4.8A) | 0.48A | 3sxrA-1s9iA:21.9 | 3sxrA-1s9iA:24.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 595VAL A 603ALA A 621VAL A 654THR A 670TYR A 672GLY A 676LEU A 799 | STI A 3 ( 3.8A)STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-4.3A)STI A 3 (-3.2A)STI A 3 ( 4.0A)STI A 3 ( 3.8A)STI A 3 (-4.4A) | 0.56A | 3sxrA-1t46A:30.0 | 3sxrA-1t46A:35.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u59 | TYROSINE-PROTEINKINASE ZAP-70 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 344VAL A 352ALA A 367MET A 390VAL A 399GLY A 420LEU A 468 | STU A 100 (-3.8A)STU A 100 (-4.8A)STU A 100 (-3.2A)NoneNoneSTU A 100 (-3.5A)STU A 100 (-4.5A) | 0.48A | 3sxrA-1u59A:32.1 | 3sxrA-1u59A:37.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlt | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 15VAL A 23ALA A 36VAL A 68TYR A 86GLY A 90LEU A 137 | HYM A 400 (-4.2A)HYM A 400 (-4.3A)HYM A 400 (-3.5A)HYM A 400 (-4.8A)HYM A 400 (-4.7A)NoneHYM A 400 (-4.5A) | 0.53A | 3sxrA-1zltA:23.7 | 3sxrA-1zltA:26.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zy4 | SERINE/THREONINE-PROTEIN KINASE GCN2 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 6 | LEU A 605VAL A 613ALA A 626VAL A 656ILE A 786TYR A 790 | NoneNoneGOL A 998 ( 3.7A)GOL A 998 (-4.9A)NoneGOL A 998 (-4.6A) | 0.40A | 3sxrA-1zy4A:20.0 | 3sxrA-1zy4A:27.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | LEU X 17VAL X 25ALA X 37MET X 58VAL X 67ILE X 80THR X 82TYR X 84GLY X 88LEU X 137 | STU X 902 (-3.8A)STU X 902 ( 4.8A)STU X 902 (-3.1A)NoneNoneNoneSTU X 902 (-4.1A)STU X 902 (-4.6A)STU X 902 (-3.5A)STU X 902 (-4.4A) | 0.53A | 3sxrA-2dq7X:34.2 | 3sxrA-2dq7X:41.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h8h | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 9 | LEU A 273VAL A 281ALA A 293VAL A 323ILE A 336THR A 338TYR A 340GLY A 344LEU A 393 | H8H A 534 (-3.8A)H8H A 534 (-4.4A)H8H A 534 (-3.2A)NoneH8H A 534 ( 4.5A)H8H A 534 (-3.1A)H8H A 534 (-4.3A)H8H A 534 (-3.3A)H8H A 534 (-4.5A) | 0.47A | 3sxrA-2h8hA:30.8 | 3sxrA-2h8hA:24.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hck | HEMATOPOETIC CELLKINASE HCK (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | LEU A 273VAL A 281ALA A 293VAL A 323ILE A 336THR A 338GLY A 344LEU A 393 | QUE A 1 (-3.9A)QUE A 1 ( 4.8A)QUE A 1 (-3.5A)NoneNoneQUE A 1 (-3.3A)QUE A 1 (-3.0A)QUE A 1 (-4.4A) | 0.61A | 3sxrA-2hckA:30.6 | 3sxrA-2hckA:32.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hen | EPHRIN TYPE-BRECEPTOR 2 (Mus musculus) |
PF07714(Pkinase_Tyr) | 7 | VAL A 643ALA A 659MET A 682ILE A 705THR A 707GLY A 713LEU A 761 | ADP A 400 ( 4.4A)ADP A 400 (-3.2A)NoneNoneADP A 400 (-4.7A)ADP A 400 ( 4.2A)ADP A 400 ( 4.7A) | 0.66A | 3sxrA-2henA:31.6 | 3sxrA-2henA:36.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 251VAL A 259ALA A 271MET A 292VAL A 301ILE A 314THR A 316GLY A 322LEU A 371 | 1BM A 499 ( 3.7A)1BM A 499 ( 4.8A)1BM A 499 (-3.6A)1BM A 499 ( 3.8A)None1BM A 499 (-3.9A)1BM A 499 (-3.2A)1BM A 499 (-3.5A)1BM A 499 (-4.4A) | 0.47A | 3sxrA-2hk5A:34.7 | 3sxrA-2hk5A:41.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 248VAL A 256ALA A 269MET A 290VAL A 299ILE A 313THR A 315GLY A 321LEU A 370 | GIN A 600 ( 4.6A)GIN A 600 ( 4.7A)GIN A 600 (-3.1A)GIN A 600 (-3.2A)GIN A 600 (-4.6A)GIN A 600 (-3.8A)GIN A 600 (-3.4A)NoneGIN A 600 (-4.7A) | 0.65A | 3sxrA-2hz0A:32.2 | 3sxrA-2hz0A:41.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0j | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF00373(FERM_M)PF07714(Pkinase_Tyr) | 7 | VAL A 436ALA A 452MET A 475VAL A 484ILE A 497GLY A 505LEU A 553 | 4ST A1687 ( 4.8A)4ST A1687 (-3.3A)NoneNoneNone4ST A1687 (-3.2A)4ST A1687 (-4.4A) | 0.62A | 3sxrA-2j0jA:31.2 | 3sxrA-2j0jA:18.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2jkm | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF07714(Pkinase_Tyr) | 7 | VAL A 436ALA A 452MET A 475VAL A 484ILE A 497GLY A 505LEU A 553 | BII A1687 ( 4.7A)BII A1687 (-3.5A)NoneNoneNoneBII A1687 (-3.6A)BII A1687 (-4.2A) | 0.55A | 3sxrA-2jkmA:31.4 | 3sxrA-2jkmA:37.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | ALA A 271MET A 292VAL A 301ILE A 314THR A 316TYR A 318GLY A 322LEU A 371 | 1N8 A 501 ( 3.4A)1N8 A 501 ( 3.6A)None1N8 A 501 ( 4.6A)1N8 A 501 ( 3.3A)1N8 A 501 ( 3.7A)1N8 A 501 ( 3.5A)1N8 A 501 ( 4.3A) | 0.58A | 3sxrA-2og8A:31.0 | 3sxrA-2og8A:44.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2og8 | PROTO-ONCOGENETYROSINE-PROTEINKINASE LCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 251VAL A 259ALA A 271MET A 292VAL A 301ILE A 314THR A 316TYR A 318 | NoneNone1N8 A 501 ( 3.4A)1N8 A 501 ( 3.6A)None1N8 A 501 ( 4.6A)1N8 A 501 ( 3.3A)1N8 A 501 ( 3.7A) | 0.52A | 3sxrA-2og8A:31.0 | 3sxrA-2og8A:44.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 588VAL A 596ALA A 614MET A 637VAL A 647THR A 663TYR A 665LEU A 785 | None | 0.59A | 3sxrA-2ogvA:28.2 | 3sxrA-2ogvA:35.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 588VAL A 596ALA A 614VAL A 647THR A 663TYR A 665GLY A 669LEU A 785 | None | 0.47A | 3sxrA-2ogvA:28.2 | 3sxrA-2ogvA:35.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2psq | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 487VAL A 495ALA A 515MET A 538TYR A 566GLY A 570LEU A 633 | None | 0.51A | 3sxrA-2psqA:32.1 | 3sxrA-2psqA:31.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qob | EPHRIN RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | VAL A 635ALA A 651MET A 674ILE A 697THR A 699GLY A 705LEU A 753 | BME A 1 (-4.9A)PTR A 701 ( 4.7A)NoneNoneNoneNoneNone | 0.66A | 3sxrA-2qobA:32.1 | 3sxrA-2qobA:32.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r2p | EPHRIN TYPE-ARECEPTOR 5 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 8 | VAL A 689ALA A 705MET A 728ILE A 751THR A 753TYR A 755GLY A 759LEU A 807 | None | 0.53A | 3sxrA-2r2pA:33.6 | 3sxrA-2r2pA:35.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r4b | RECEPTORTYROSINE-PROTEINKINASE ERBB-4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 724VAL A 732ALA A 749VAL A 781THR A 796GLY A 802LEU A 850 | GW7 A 1 ( 4.2A)GW7 A 1 ( 4.8A)GW7 A 1 (-3.3A)GW7 A 1 ( 4.7A)GW7 A 1 (-4.0A)GW7 A 1 (-3.6A)GW7 A 1 (-4.2A) | 0.68A | 3sxrA-2r4bA:29.3 | 3sxrA-2r4bA:33.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xyu | EPHRIN TYPE-ARECEPTOR 4, (Mus musculus) |
PF07714(Pkinase_Tyr) | 8 | VAL A 635ALA A 651MET A 674ILE A 697THR A 699TYR A 701GLY A 705LEU A 753 | Q9G A1898 ( 4.7A)Q9G A1898 (-3.2A)Q9G A1898 (-3.9A)Q9G A1898 ( 4.6A)Q9G A1898 (-3.5A)Q9G A1898 (-4.8A)Q9G A1898 ( 3.8A)Q9G A1898 (-4.3A) | 0.53A | 3sxrA-2xyuA:32.1 | 3sxrA-2xyuA:37.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xyu | EPHRIN TYPE-ARECEPTOR 4, (Mus musculus) |
PF07714(Pkinase_Tyr) | 7 | VAL A 635ALA A 651MET A 674ILE A 697THR A 699TYR A 701SER A 763 | Q9G A1898 ( 4.7A)Q9G A1898 (-3.2A)Q9G A1898 (-3.9A)Q9G A1898 ( 4.6A)Q9G A1898 (-3.5A)Q9G A1898 (-4.8A)Q9G A1898 (-3.2A) | 0.65A | 3sxrA-2xyuA:32.1 | 3sxrA-2xyuA:37.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2z8c | INSULIN RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A1002VAL A1010ALA A1028MET A1051VAL A1060GLY A1082 | S91 A 1 ( 4.1A)S91 A 1 ( 4.9A)S91 A 1 (-3.2A)NoneNoneS91 A 1 (-3.3A) | 0.37A | 3sxrA-2z8cA:30.6 | 3sxrA-2z8cA:37.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zv7 | TYROSINE-PROTEINKINASE LYN (Mus musculus) |
PF07714(Pkinase_Tyr) | 9 | LEU A 253VAL A 261ALA A 273MET A 294VAL A 303ILE A 317THR A 319GLY A 325LEU A 374 | None | 0.63A | 3sxrA-2zv7A:33.9 | 3sxrA-2zv7A:43.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b2t | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 487VAL A 495ALA A 515MET A 538TYR A 566GLY A 570LEU A 633 | M33 A1996 (-4.0A)M33 A1996 ( 4.7A)M33 A1996 (-3.3A)NoneM33 A1996 ( 4.7A)M33 A1996 ( 4.8A)M33 A1996 (-4.5A) | 0.30A | 3sxrA-3b2tA:31.9 | 3sxrA-3b2tA:36.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | VAL A 209ALA A 220MET A 240VAL A 249ILE A 264THR A 266TYR A 268GLY A 272LEU A 321 | None | 0.53A | 3sxrA-3d7uA:32.8 | 3sxrA-3d7uA:42.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3fzp | PROTEIN TYROSINEKINASE 2 BETA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 431VAL A 439ALA A 455VAL A 487ILE A 500GLY A 508LEU A 556 | AGS A 999 ( 4.4A)AGS A 999 (-4.6A)AGS A 999 (-3.6A)NoneNoneNoneAGS A 999 (-4.5A) | 0.68A | 3sxrA-3fzpA:30.8 | 3sxrA-3fzpA:37.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3hng | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 833VAL A 841ALA A 859VAL A 892TYR A 911GLY A 915LEU A1029 | 8ST A2001 ( 4.7A)8ST A2001 ( 4.6A)8ST A2001 ( 3.8A)8ST A2001 ( 4.7A)8ST A2001 (-4.9A)NoneNone | 0.64A | 3sxrA-3hngA:29.0 | 3sxrA-3hngA:33.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kex | RECEPTORTYROSINE-PROTEINKINASE ERBB-3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 696VAL A 704VAL A 753THR A 768TYR A 770GLY A 774LEU A 822 | ANP A 1 (-4.4A)ANP A 1 (-3.9A)NoneANP A 1 ( 4.8A)ANP A 1 (-4.3A)ANP A 1 ( 4.9A)ANP A 1 (-4.7A) | 0.48A | 3sxrA-3kexA:27.6 | 3sxrA-3kexA:31.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kul | EPHRIN TYPE-ARECEPTOR 8 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 7 | VAL A 649ALA A 665ILE A 711THR A 713TYR A 715GLY A 719LEU A 767 | NoneNoneNoneNoneGOL A 403 (-4.1A)GOL A 403 (-3.4A)None | 0.64A | 3sxrA-3kulA:33.8 | 3sxrA-3kulA:35.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kul | EPHRIN TYPE-ARECEPTOR 8 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 7 | VAL A 649ALA A 665MET A 688THR A 713TYR A 715GLY A 719LEU A 767 | NoneNoneNoneNoneGOL A 403 (-4.1A)GOL A 403 (-3.4A)None | 0.59A | 3sxrA-3kulA:33.8 | 3sxrA-3kulA:35.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdy | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-1B (Homo sapiens) |
PF07714(Pkinase_Tyr)PF08515(TGF_beta_GS) | 6 | VAL A 218ALA A 229THR A 279TYR A 281GLY A 285LEU A 339 | LDN A 1 ( 4.8A)LDN A 1 (-3.6A)LDN A 1 (-3.8A)LDN A 1 ( 4.8A)LDN A 1 (-3.3A)LDN A 1 (-4.5A) | 0.31A | 3sxrA-3mdyA:26.1 | 3sxrA-3mdyA:27.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 88VAL A 96ALA A 109MET A 134TYR A 161GLY A 165LEU A 212 | JOZ A 361 (-4.1A)JOZ A 361 ( 4.7A)JOZ A 361 (-3.4A)NoneNoneNoneNone | 0.66A | 3sxrA-3nuuA:25.1 | 3sxrA-3nuuA:26.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pp0 | RECEPTORTYROSINE-PROTEINKINASE ERBB-2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 726VAL A 734ALA A 751THR A 798GLY A 804LEU A 852 | 03Q A 1 (-3.8A)03Q A 1 (-4.5A)03Q A 1 (-3.1A)03Q A 1 (-4.1A)03Q A 1 ( 3.9A)03Q A 1 (-4.4A) | 0.43A | 3sxrA-3pp0A:30.8 | 3sxrA-3pp0A:30.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 8 | VAL A 565ALA A 576MET A 600VAL A 609THR A 625TYR A 627GLY A 631LEU A 683 | STU A 1 (-4.9A)STU A 1 (-3.3A)NoneNoneSTU A 1 (-4.1A)STU A 1 (-4.4A)STU A 1 (-3.2A)STU A 1 (-4.3A) | 0.48A | 3sxrA-3ppzA:32.0 | 3sxrA-3ppzA:34.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 8 | VAL A 565ALA A 576VAL A 609ILE A 623THR A 625TYR A 627GLY A 631LEU A 683 | STU A 1 (-4.9A)STU A 1 (-3.3A)NoneNoneSTU A 1 (-4.1A)STU A 1 (-4.4A)STU A 1 (-3.2A)STU A 1 (-4.3A) | 0.47A | 3sxrA-3ppzA:32.0 | 3sxrA-3ppzA:34.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3s95 | LIM DOMAIN KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 345MET A 388THR A 413TYR A 415ILE A 416GLY A 419LEU A 467 | STU A 1 (-3.8A)NoneSTU A 1 (-3.9A)STU A 1 (-4.7A)STU A 1 (-4.3A)STU A 1 (-3.6A)STU A 1 (-4.6A) | 0.61A | 3sxrA-3s95A:25.6 | 3sxrA-3s95A:30.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3sxs | CYTOPLASMICTYROSINE-PROTEINKINASE BMX (Homo sapiens) |
PF07714(Pkinase_Tyr) | 12 | LEU A 423VAL A 431ALA A 443MET A 464VAL A 473ILE A 487THR A 489TYR A 491ILE A 492GLY A 495LEU A 543SER A 553 | PP2 A 1 (-4.1A)PP2 A 1 (-4.5A)PP2 A 1 (-3.2A)PP2 A 1 ( 4.3A)NonePP2 A 1 (-3.6A)PP2 A 1 (-3.3A)PP2 A 1 ( 4.9A)PP2 A 1 (-4.1A)PP2 A 1 ( 4.2A)PP2 A 1 (-4.6A)PP2 A 1 (-3.5A) | 0.38A | 3sxrA-3sxsA:42.4 | 3sxrA-3sxsA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 484VAL A 492ALA A 512MET A 535TYR A 563GLY A 567LEU A 630 | 07J A 1 ( 4.3A)07J A 1 (-4.0A)07J A 1 (-3.5A)07J A 1 (-3.8A)07J A 1 (-4.7A)07J A 1 (-3.7A)07J A 1 ( 4.4A) | 0.63A | 3sxrA-3tt0A:28.8 | 3sxrA-3tt0A:31.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v5q | NT-3 GROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 544VAL A 552ALA A 570VAL A 601TYR A 619GLY A 623LEU A 686 | 0F4 A 902 ( 4.2A)None0F4 A 902 (-3.2A)None0F4 A 902 (-4.2A)0F4 A 902 (-3.4A)0F4 A 902 (-4.5A) | 0.34A | 3sxrA-3v5qA:30.9 | 3sxrA-3v5qA:37.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wig | DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 75VAL A 83ALA A 96VAL A 128ILE A 142GLY A 150LEU A 198 | ANP A 401 (-3.8A)ANP A 401 ( 4.3A)ANP A 401 (-3.2A)CHU A 403 (-4.2A)CHU A 403 (-3.8A)ANP A 401 ( 4.3A)ANP A 401 (-4.8A) | 0.52A | 3sxrA-3wigA:23.3 | 3sxrA-3wigA:25.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3wzd | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 840VAL A 848ALA A 866VAL A 899GLY A 922LEU A1035 | LEV A1201 ( 3.8A)LEV A1201 ( 4.9A)LEV A1201 (-3.5A)NoneLEV A1201 (-3.6A)LEV A1201 (-4.8A) | 0.38A | 3sxrA-3wzdA:29.8 | 3sxrA-3wzdA:36.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A1951VAL A1959ALA A1978MET A2001ILE A2024GLY A2032LEU A2086 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)NoneNoneVGH A3000 (-3.5A)VGH A3000 (-4.3A) | 0.80A | 3sxrA-3zbfA:25.2 | 3sxrA-3zbfA:39.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zfx | EPHRIN TYPE-BRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | VAL A 633ALA A 649MET A 672ILE A 695THR A 697GLY A 703LEU A 751 | None | 0.53A | 3sxrA-3zfxA:33.0 | 3sxrA-3zfxA:38.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4af3 | AURORA KINASE B (Homo sapiens) |
PF00069(Pkinase) | 6 | LEU A 83VAL A 91ALA A 104TYR A 156GLY A 160LEU A 207 | VX6 A 500 (-3.8A)VX6 A 500 ( 4.8A)VX6 A 500 (-3.4A)VX6 A 500 (-4.2A)VX6 A 500 (-3.3A)VX6 A 500 (-4.6A) | 0.42A | 3sxrA-4af3A:20.8 | 3sxrA-4af3A:23.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4at3 | BDNF/NT-3 GROWTHFACTORS RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 560VAL A 568ALA A 586VAL A 617TYR A 635GLY A 639LEU A 699 | LTI A1839 ( 4.2A)NoneLTI A1839 (-3.3A)NoneLTI A1839 (-4.7A)LTI A1839 (-3.4A)LTI A1839 (-4.2A) | 0.43A | 3sxrA-4at3A:30.2 | 3sxrA-4at3A:36.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4aw5 | EPHRIN TYPE-BRECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | VAL A 105ALA A 121MET A 144ILE A 167THR A 169GLY A 175LEU A 223 | 30K A1365 ( 4.6A)30K A1365 (-3.2A)NoneNone30K A1365 (-3.8A)30K A1365 (-3.5A)30K A1365 (-4.5A) | 0.47A | 3sxrA-4aw5A:32.1 | 3sxrA-4aw5A:35.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bc6 | SERINE/THREONINE-PROTEIN KINASE 10 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 42VAL A 50ALA A 63VAL A 94ILE A 108GLY A 116LEU A 164 | XZN A1317 (-3.6A)XZN A1317 ( 4.7A)XZN A1317 (-3.5A)XZN A1317 (-4.4A)XZN A1317 (-4.4A)XZN A1317 ( 3.7A)XZN A1317 (-4.7A) | 0.64A | 3sxrA-4bc6A:22.5 | 3sxrA-4bc6A:29.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 7 | LEU A 663VAL A 671ALA A 684VAL A 721TYR A 739GLY A 743LEU A 789 | AGS A1985 (-4.2A)AGS A1985 (-4.6A)AGS A1985 (-3.5A)NoneNoneNoneAGS A1985 (-4.8A) | 0.48A | 3sxrA-4crsA:24.4 | 3sxrA-4crsA:25.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4e93 | TYROSINE-PROTEINKINASE FES/FPS (Homo sapiens) |
PF00017(SH2)PF07714(Pkinase_Tyr) | 6 | VAL A 575ALA A 588VAL A 620ILE A 634GLY A 642LEU A 690 | GUI A 901 (-4.5A)GUI A 901 (-3.4A)NoneNoneGUI A 901 (-3.5A)GUI A 901 (-4.3A) | 0.39A | 3sxrA-4e93A:33.6 | 3sxrA-4e93A:37.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eqm | PROTEIN KINASE (Staphylococcusaureus) |
PF00069(Pkinase) | 7 | LEU A 16VAL A 24ALA A 37VAL A 71TYR A 89ILE A 90LEU A 140 | ANP A 300 (-4.7A)ANP A 300 ( 4.7A)ANP A 300 ( 3.8A)NoneANP A 300 (-4.3A)ANP A 300 (-4.8A)ANP A 300 (-4.7A) | 0.64A | 3sxrA-4eqmA:23.4 | 3sxrA-4eqmA:24.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4f4p | TYROSINE-PROTEINKINASE SYK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 377VAL A 385ALA A 400MET A 424VAL A 433GLY A 454LEU A 501 | 0SB A 701 ( 3.9A)0SB A 701 (-4.0A)0SB A 701 (-3.3A)NoneNone0SB A 701 (-3.5A)0SB A 701 (-4.4A) | 0.59A | 3sxrA-4f4pA:31.9 | 3sxrA-4f4pA:38.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fod | ALK TYROSINE KINASERECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A1122VAL A1130ALA A1148VAL A1180ILE A1194GLY A1202LEU A1256 | 0UV A1501 (-3.8A)0UV A1501 (-4.5A)0UV A1501 (-3.4A)0UV A1501 ( 4.9A)None0UV A1501 (-3.6A)0UV A1501 (-4.6A) | 0.44A | 3sxrA-4fodA:30.4 | 3sxrA-4fodA:33.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 828VAL A 836ALA A 853VAL A 884TYR A 904GLY A 908LEU A 956 | 19S A1201 (-3.9A)19S A1201 (-4.4A)19S A1201 (-3.3A)None19S A1201 (-4.7A)19S A1201 ( 3.8A)19S A1201 (-4.5A) | 0.44A | 3sxrA-4hviA:30.9 | 3sxrA-4hviA:32.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hzs | ACTIVATED CDC42KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14604(SH3_9) | 6 | LEU A 132VAL A 140ALA A 156THR A 205GLY A 211LEU A 259 | None | 0.40A | 3sxrA-4hzsA:16.7 | 3sxrA-4hzsA:39.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4id7 | ACTIVATED CDC42KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 132VAL A 140ALA A 156THR A 205GLY A 211LEU A 259 | 1G0 A 401 ( 4.5A)1G0 A 401 (-4.4A)1G0 A 401 (-3.6A)1G0 A 401 (-3.2A)1G0 A 401 ( 4.5A)1G0 A 401 (-4.6A) | 0.43A | 3sxrA-4id7A:33.1 | 3sxrA-4id7A:39.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | LEU A 273VAL A 281ALA A 293VAL A 323ILE A 336TYR A 340GLY A 344LEU A 393 | 0J9 A 601 (-4.0A)0J9 A 601 (-4.4A)0J9 A 601 (-3.3A)None0J9 A 601 (-4.4A)0J9 A 601 ( 4.7A)0J9 A 601 ( 4.1A)0J9 A 601 (-4.5A) | 0.52A | 3sxrA-4k11A:30.4 | 3sxrA-4k11A:29.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 478VAL A 486ALA A 506MET A 529TYR A 557GLY A 561LEU A 624 | ACP A 801 (-3.8A)ACP A 801 (-4.2A)ACP A 801 (-3.3A)NoneNoneACP A 801 ( 4.6A)ACP A 801 (-4.4A) | 0.49A | 3sxrA-4k33A:32.6 | 3sxrA-4k33A:34.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lg4 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 33VAL A 41ALA A 54MET A 74VAL A 83ILE A 97TYR A 101GLY A 105 | GOL A 404 ( 3.6A)GOL A 404 (-4.5A)GOL A 404 ( 3.1A)NoneGOL A 403 (-4.1A)NoneGOL A 404 ( 4.9A)GOL A 404 (-3.6A) | 0.54A | 3sxrA-4lg4A:25.4 | 3sxrA-4lg4A:29.93 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lgg | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Gallus gallus) |
PF07714(Pkinase_Tyr) | 9 | LEU A 273VAL A 281ALA A 293MET A 314VAL A 323ILE A 336TYR A 340GLY A 344LEU A 393 | VGG A 601 (-3.2A)VGG A 601 ( 3.5A)VGG A 601 (-3.5A)VGG A 601 ( 3.6A)VGG A 601 ( 4.8A)VGG A 601 (-4.2A)VGG A 601 ( 4.0A)VGG A 601 ( 3.2A)VGG A 601 (-4.5A) | 0.56A | 3sxrA-4lggA:29.3 | 3sxrA-4lggA:43.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o38 | CYCLIN-G-ASSOCIATEDKINASE (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 46ALA A 67MET A 89VAL A 99THR A 123GLY A 128LEU A 180 | SIN A 401 ( 3.9A)SIN A 401 ( 3.7A)NoneNoneNoneSIN A 401 (-3.5A)SIN A 401 ( 4.5A) | 0.77A | 3sxrA-4o38A:20.5 | 3sxrA-4o38A:26.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o38 | CYCLIN-G-ASSOCIATEDKINASE (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 46VAL A 54ALA A 67VAL A 99THR A 123GLY A 128LEU A 180 | SIN A 401 ( 3.9A)NoneSIN A 401 ( 3.7A)NoneNoneSIN A 401 (-3.5A)SIN A 401 ( 4.5A) | 0.47A | 3sxrA-4o38A:20.5 | 3sxrA-4o38A:26.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otd | SERINE/THREONINE-PROTEIN KINASE N1 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 7 | LEU A 627VAL A 635ALA A 648VAL A 685TYR A 703GLY A 707LEU A 753 | None | 0.57A | 3sxrA-4otdA:25.1 | 3sxrA-4otdA:26.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p2k | EPHRIN TYPE-ARECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 7 | VAL A 627ALA A 644ILE A 690THR A 692TYR A 694GLY A 698LEU A 746 | None | 0.57A | 3sxrA-4p2kA:33.4 | 3sxrA-4p2kA:38.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p2k | EPHRIN TYPE-ARECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 7 | VAL A 627ALA A 644MET A 667ILE A 690THR A 692TYR A 694SER A 756 | None | 0.55A | 3sxrA-4p2kA:33.4 | 3sxrA-4p2kA:38.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 616VAL A 624ALA A 642VAL A 675TYR A 693GLY A 697LEU A 818 | P30 A1001 (-3.8A)NoneP30 A1001 (-3.4A)NoneP30 A1001 (-4.1A)P30 A1001 (-3.4A)P30 A1001 (-4.6A) | 0.38A | 3sxrA-4rt7A:30.2 | 3sxrA-4rt7A:32.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 10 | LEU A 14VAL A 22ALA A 35MET A 56VAL A 65ILE A 79THR A 81TYR A 83GLY A 87LEU A 136 | ACP A1264 ( 4.5A)ACP A1264 (-4.7A)ACP A1264 (-2.9A)NoneNoneNoneACP A1264 (-4.5A)ACP A1264 ( 4.5A)ACP A1264 (-3.5A)ACP A1264 ( 4.8A) | 0.53A | 3sxrA-4ueuA:33.7 | 3sxrA-4ueuA:52.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wsq | AP2-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 52VAL A 60ALA A 72MET A 94VAL A 104GLY A 132LEU A 183 | KSA A 405 ( 4.0A)KSA A 405 ( 4.9A)KSA A 405 (-3.2A)NoneNoneKSA A 405 (-3.5A)KSA A 405 (-4.6A) | 0.60A | 3sxrA-4wsqA:24.8 | 3sxrA-4wsqA:27.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wsq | AP2-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 52VAL A 60ALA A 72VAL A 104ILE A 124GLY A 132LEU A 183 | KSA A 405 ( 4.0A)KSA A 405 ( 4.9A)KSA A 405 (-3.2A)NoneNoneKSA A 405 (-3.5A)KSA A 405 (-4.6A) | 0.44A | 3sxrA-4wsqA:24.8 | 3sxrA-4wsqA:27.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xey | TYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
no annotation | 8 | LEU B 267VAL B 275ALA B 288MET B 309VAL B 318THR B 334GLY B 340LEU B 389 | 1N1 B 601 (-3.7A)1N1 B 601 ( 4.9A)1N1 B 601 (-3.5A)1N1 B 601 (-3.7A)1N1 B 601 ( 4.3A)1N1 B 601 (-3.3A)1N1 B 601 (-3.5A)1N1 B 601 (-4.3A) | 0.57A | 3sxrA-4xeyB:33.4 | 3sxrA-4xeyB:30.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xey | TYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
no annotation | 8 | LEU B 267VAL B 275ALA B 288VAL B 318ILE B 332THR B 334GLY B 340LEU B 389 | 1N1 B 601 (-3.7A)1N1 B 601 ( 4.9A)1N1 B 601 (-3.5A)1N1 B 601 ( 4.3A)1N1 B 601 (-4.1A)1N1 B 601 (-3.3A)1N1 B 601 (-3.5A)1N1 B 601 (-4.3A) | 0.44A | 3sxrA-4xeyB:33.4 | 3sxrA-4xeyB:30.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xi2 | TYROSINE-PROTEINKINASE BTK (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 9 | LEU A 408VAL A 416ALA A 428VAL A 458ILE A 472THR A 474TYR A 476GLY A 480LEU A 528 | None | 0.83A | 3sxrA-4xi2A:32.0 | 3sxrA-4xi2A:43.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xi2 | TYROSINE-PROTEINKINASE BTK (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | LEU A 408VAL A 416ALA A 428VAL A 458ILE A 472THR A 474TYR A 476SER A 538 | None | 0.69A | 3sxrA-4xi2A:32.0 | 3sxrA-4xi2A:43.03 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 616VAL A 624ALA A 642VAL A 675TYR A 693GLY A 697LEU A 818 | P30 A1001 (-4.0A)P30 A1001 ( 4.8A)P30 A1001 (-3.5A)NoneP30 A1001 ( 4.4A)P30 A1001 (-3.5A)P30 A1001 (-4.3A) | 0.52A | 3sxrA-4xufA:29.7 | 3sxrA-4xufA:39.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4y93 | NON-SPECIFICPROTEIN-TYROSINEKINASE,NON-SPECIFICPROTEIN-TYROSINEKINASE (Bos taurus) |
PF00169(PH)PF00779(BTK)PF07714(Pkinase_Tyr) | 9 | LEU A 408VAL A 416ALA A 428VAL A 458ILE A 472THR A 474TYR A 476GLY A 480LEU A 528 | 746 A 702 (-3.8A)746 A 702 ( 4.3A)746 A 702 (-2.4A)NoneNone746 A 702 (-3.7A)746 A 702 (-4.4A)746 A 702 (-3.6A)746 A 702 (-4.4A) | 0.41A | 3sxrA-4y93A:32.9 | 3sxrA-4y93A:40.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yff | SERINE/THREONINE-PROTEIN KINASE TNNI3K (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 477ALA A 488ILE A 537THR A 539TYR A 541LEU A 595 | None4CV A 801 (-3.5A)None4CV A 801 (-2.8A)4CV A 801 (-3.9A)4CV A 801 (-4.4A) | 0.39A | 3sxrA-4yffA:26.0 | 3sxrA-4yffA:27.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | LEU A 484VAL A 492ALA A 512MET A 535TYR A 563GLY A 567LEU A 630 | 38O A1769 (-3.2A)38O A1769 (-4.5A)38O A1769 (-3.6A)EDO A1766 (-3.5A)38O A1769 (-4.2A)38O A1769 (-3.4A)38O A1769 (-4.6A) | 0.54A | 3sxrA-5a46A:29.1 | 3sxrA-5a46A:32.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5f1z | NON-RECEPTORTYROSINE-PROTEINKINASE TYK2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | LEU A 903VAL A 911ALA A 928TYR A 980GLY A 984LEU A1030 | 5U3 A1200 (-3.8A)5U3 A1200 ( 4.4A)5U3 A1200 (-3.5A)5U3 A1200 (-4.5A)5U3 A1200 (-3.2A)5U3 A1200 (-4.4A) | 0.26A | 3sxrA-5f1zA:29.8 | 3sxrA-5f1zA:33.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 599VAL A 607ALA A 625MET A 648VAL A 658THR A 674TYR A 676GLY A 680LEU A 825 | 748 A1001 (-3.8A)748 A1001 ( 4.7A)748 A1001 (-3.7A)748 A1001 (-3.4A)748 A1001 ( 4.8A)748 A1001 (-3.2A)748 A1001 (-4.0A)748 A1001 ( 4.0A)748 A1001 (-4.3A) | 0.65A | 3sxrA-5grnA:30.1 | 3sxrA-5grnA:35.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 599VAL A 607ALA A 625VAL A 658ILE A 672THR A 674TYR A 676GLY A 680LEU A 825 | 748 A1001 (-3.8A)748 A1001 ( 4.7A)748 A1001 (-3.7A)748 A1001 ( 4.8A)748 A1001 (-3.9A)748 A1001 (-3.2A)748 A1001 (-4.0A)748 A1001 ( 4.0A)748 A1001 (-4.3A) | 0.56A | 3sxrA-5grnA:30.1 | 3sxrA-5grnA:35.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gz8 | PROTEIN O-MANNOSEKINASE (Mus musculus) |
PF07714(Pkinase_Tyr) | 8 | VAL A 94ALA A 105VAL A 134ILE A 146THR A 148TYR A 150GLY A 154LEU A 215 | None | 0.55A | 3sxrA-5gz8A:20.8 | 3sxrA-5gz8A:25.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gza | PROTEIN O-MANNOSEKINASE (Danio rerio) |
PF07714(Pkinase_Tyr) | 7 | VAL A 93ALA A 104VAL A 133THR A 147TYR A 149GLY A 153LEU A 214 | ADP A 401 (-4.4A)ADP A 401 (-3.2A)NoneADP A 401 ( 4.8A)ADP A 401 ( 4.8A)ADP A 401 ( 4.1A)ADP A 401 (-4.4A) | 0.45A | 3sxrA-5gzaA:20.3 | 3sxrA-5gzaA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3o | BMP-2-INDUCIBLEPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 7 | LEU A 57VAL A 65ALA A 77ILE A 128TYR A 132GLY A 136LEU A 187 | IDV A 401 (-3.8A)IDV A 401 (-4.6A)IDV A 401 (-3.6A)NoneIDV A 401 (-3.5A)IDV A 401 (-3.4A)IDV A 401 (-4.4A) | 0.39A | 3sxrA-5i3oA:24.7 | 3sxrA-5i3oA:27.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3o | BMP-2-INDUCIBLEPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 57VAL A 65ALA A 77MET A 99VAL A 109TYR A 132GLY A 136LEU A 187 | IDV A 401 (-3.8A)IDV A 401 (-4.6A)IDV A 401 (-3.6A)NoneNoneIDV A 401 (-3.5A)IDV A 401 (-3.4A)IDV A 401 (-4.4A) | 0.46A | 3sxrA-5i3oA:24.7 | 3sxrA-5i3oA:27.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5t | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE KINASE3 (Homo sapiens) |
PF00069(Pkinase) | 7 | VAL A 30ALA A 43MET A 65VAL A 74ILE A 88GLY A 96LEU A 143 | 6G2 A 901 ( 4.9A)6G2 A 901 (-3.2A)NoneNoneNone6G2 A 901 (-3.6A)6G2 A 901 (-4.7A) | 0.56A | 3sxrA-5j5tA:22.8 | 3sxrA-5j5tA:24.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5kbr | SERINE/THREONINE-PROTEIN KINASE PAK 1 (Homo sapiens) |
PF00069(Pkinase) | 7 | VAL A 284ALA A 297MET A 319VAL A 328TYR A 346GLY A 350LEU A 396 | IPW A 601 (-4.2A)IPW A 601 (-3.5A)IPW A 601 (-4.1A)NoneIPW A 601 (-4.5A)IPW A 601 ( 3.8A)IPW A 601 (-4.5A) | 0.46A | 3sxrA-5kbrA:24.3 | 3sxrA-5kbrA:30.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5loh | SERINE/THREONINE-PROTEIN KINASEGREATWALL,SERINE/THREONINE-PROTEINKINASE GREATWALL (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 49ALA A 60VAL A 94TYR A 112GLY A 116LEU A 163 | NoneSTU A 901 (-3.3A)NoneSTU A 901 (-4.6A)STU A 901 (-3.5A)STU A 901 (-4.5A) | 0.38A | 3sxrA-5lohA:22.0 | 3sxrA-5lohA:26.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vdk | WEE1-LIKE PROTEINKINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 226ALA A 239VAL A 273ILE A 287TYR A 291GLY A 295 | 8X7 A 501 ( 4.5A)8X7 A 501 ( 3.7A)8X7 A 501 ( 4.6A)PO4 A 502 (-3.4A)8X7 A 501 (-4.2A)8X7 A 501 (-3.6A) | 0.42A | 3sxrA-5vdkA:17.8 | 3sxrA-5vdkA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w5j | RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 2 (Homo sapiens) |
no annotation | 8 | LEU A 24VAL A 32ALA A 45ILE A 93THR A 95TYR A 97GLY A 101LEU A 153 | 9WS A 401 ( 4.2A)9WS A 401 ( 4.6A)9WS A 401 (-3.3A)9WS A 401 (-3.9A)9WS A 401 (-3.2A)None9WS A 401 ( 4.3A)9WS A 401 (-4.6A) | 0.49A | 3sxrA-5w5jA:24.0 | 3sxrA-5w5jA:28.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wno | RECEPTORTYROSINE-PROTEINKINASE LET-23 (Caenorhabditiselegans) |
no annotation | 8 | LEU A 891VAL A 899ALA A 917ILE A 961THR A 963TYR A 965GLY A 969LEU A1017 | ANP A1201 (-4.1A)ANP A1201 (-4.4A)ANP A1201 (-3.3A)NoneANP A1201 (-3.9A)ANP A1201 (-4.4A)ANP A1201 ( 4.6A)ANP A1201 (-4.7A) | 0.49A | 3sxrA-5wnoA:27.9 | 3sxrA-5wnoA:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ao5 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
no annotation | 8 | LEU A 33VAL A 41ALA A 54VAL A 83ILE A 97TYR A 101GLY A 105LEU A 153 | ANP A 501 ( 3.8A)ANP A 501 (-4.4A)ANP A 501 ( 3.7A)NoneNoneANP A 501 ( 4.2A)ANP A 501 ( 4.0A)ANP A 501 (-4.6A) | 0.56A | 3sxrA-6ao5A:23.0 | 3sxrA-6ao5A:24.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7y | TYROSINE-PROTEINKINASE JAK1 (Homo sapiens) |
no annotation | 6 | LEU A 881VAL A 889ALA A 906VAL A 938GLY A 962LEU A1010 | ADP A1201 ( 4.5A)ADP A1201 (-4.3A)ADP A1201 (-3.4A)NoneADP A1201 ( 4.1A)ADP A1201 (-4.5A) | 0.38A | 3sxrA-6c7yA:30.7 | 3sxrA-6c7yA:15.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cz4 | PROTEIN-TYROSINEKINASE 6 (Homo sapiens) |
no annotation | 7 | LEU A 197VAL A 205ALA A 217ILE A 262THR A 264GLY A 270LEU A 319 | FKY A9001 (-4.1A)FKY A9001 ( 4.6A)FKY A9001 (-3.3A)NoneFKY A9001 (-3.0A)FKY A9001 (-3.3A)FKY A9001 ( 4.9A) | 0.66A | 3sxrA-6cz4A:30.1 | 3sxrA-6cz4A:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3d | INTERLEUKIN-1RECEPTOR-ASSOCIATEDKINASE 4 (Homo sapiens) |
no annotation | 6 | VAL A 200ALA A 211VAL A 246TYR A 264GLY A 268LEU A 318 | CJT A 502 ( 4.8A)CJT A 502 (-3.4A)NoneCJT A 502 (-4.5A)CJT A 502 ( 4.3A)CJT A 502 (-4.7A) | 0.43A | 3sxrA-6f3dA:25.3 | 3sxrA-6f3dA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fek | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
no annotation | 6 | LEU A 730VAL A 738ALA A 756TYR A 806GLY A 810LEU A 881 | ADN A1104 ( 4.0A)ADN A1104 (-4.4A)ADN A1104 (-3.4A)ADN A1104 ( 4.1A)ADN A1104 ( 3.8A)ADN A1104 (-4.3A) | 0.40A | 3sxrA-6fekA:31.9 | 3sxrA-6fekA:17.18 |