SIMILAR PATTERNS OF AMINO ACIDS FOR 3SVP_B_H4BB760_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)


(Lactobacillus
sp. 30A)
PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C)
4 TRP A 673
PHE A 681
GLU A 649
VAL A 667
None
1.30A 3svpA-1c4kA:
0.0
3svpB-1c4kA:
0.0
3svpA-1c4kA:
19.07
3svpB-1c4kA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvk PRP18

(Saccharomyces
cerevisiae)
PF02840
(Prp18)
4 TRP A 242
PHE A 239
GLU A 241
ARG A 123
None
1.47A 3svpA-1dvkA:
1.7
3svpB-1dvkA:
1.5
3svpA-1dvkA:
17.18
3svpB-1dvkA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)


(Pseudomonas
aeruginosa)
PF01011
(PQQ)
PF13360
(PQQ_2)
4 PHE A 501
GLU A 519
VAL A  41
TRP A 521
None
1.29A 3svpA-1flgA:
undetectable
3svpB-1flgA:
0.0
3svpA-1flgA:
19.67
3svpB-1flgA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE


(Thermus
thermophilus)
PF00764
(Arginosuc_synth)
4 PHE A 220
GLU A 222
ARG A 282
VAL A 226
None
1.35A 3svpA-1kh2A:
0.0
3svpB-1kh2A:
0.1
3svpA-1kh2A:
22.65
3svpB-1kh2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylosinus
trichosporium)
PF02332
(Phenol_Hydrox)
4 PHE D  35
GLU D 132
VAL D  28
TRP D  31
None
1.39A 3svpA-1mhzD:
0.0
3svpB-1mhzD:
0.0
3svpA-1mhzD:
20.85
3svpB-1mhzD:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzb FERRIC UPTAKE
REGULATION PROTEIN


(Pseudomonas
aeruginosa)
PF01475
(FUR)
4 PHE A  79
GLU A  36
ARG A  69
VAL A  54
None
1.08A 3svpA-1mzbA:
0.2
3svpB-1mzbA:
0.5
3svpA-1mzbA:
16.59
3svpB-1mzbA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE


(Thermotoga
maritima)
PF01048
(PNP_UDP_1)
4 TRP A 162
PHE A 265
GLU A 161
VAL A 221
None
1.46A 3svpA-1vmkA:
undetectable
3svpB-1vmkA:
0.0
3svpA-1vmkA:
21.48
3svpB-1vmkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT


(Pseudomonas
fluorescens)
PF00866
(Ring_hydroxyl_B)
4 PHE B 163
GLU B  26
ARG B 156
VAL B 128
None
1.20A 3svpA-1wqlB:
0.0
3svpB-1wqlB:
0.0
3svpA-1wqlB:
19.79
3svpB-1wqlB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
4 PHE A 722
GLU A 693
ARG A 708
VAL A1424
None
1.02A 3svpA-2b39A:
0.0
3svpB-2b39A:
0.0
3svpA-2b39A:
13.58
3svpB-2b39A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens)
PF00079
(Serpin)
4 TRP I 225
PHE I 274
GLU I 378
VAL I 375
None
1.48A 3svpA-2b4xI:
undetectable
3svpB-2b4xI:
undetectable
3svpA-2b4xI:
22.01
3svpB-2b4xI:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A
ADENYLYLSULFATE
REDUCTASE, SUBUNIT B


(Archaeoglobus
fulgidus)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9)
4 TRP B 788
GLU A 360
ARG A  62
VAL A 367
None
1.33A 3svpA-2fjaB:
undetectable
3svpB-2fjaB:
undetectable
3svpA-2fjaB:
18.25
3svpB-2fjaB:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN


(Clostridium
acetobutylicum)
PF01979
(Amidohydro_1)
4 PHE A  99
GLU A 101
ARG A 202
TRP A  93
None
None
GUN  A 503 (-3.7A)
None
1.40A 3svpA-2i9uA:
undetectable
3svpB-2i9uA:
0.4
3svpA-2i9uA:
20.97
3svpB-2i9uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2noz N-GLYCOSYLASE/DNA
LYASE


(Homo sapiens)
PF00730
(HhH-GPD)
PF07934
(OGG_N)
4 PHE A 303
GLU A 298
VAL A 267
TRP A 272
None
1.14A 3svpA-2nozA:
undetectable
3svpB-2nozA:
undetectable
3svpA-2nozA:
22.30
3svpB-2nozA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE


(Pyrococcus
furiosus)
PF00722
(Glyco_hydro_16)
4 TRP A 252
PHE A 254
GLU A 251
VAL A 245
None
None
MRD  A1301 (-4.3A)
None
1.43A 3svpA-2vy0A:
undetectable
3svpB-2vy0A:
undetectable
3svpA-2vy0A:
20.00
3svpB-2vy0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV


(Homo sapiens)
PF00069
(Pkinase)
4 TRP A 266
PHE A 261
ARG A 278
VAL A 269
None
1.42A 3svpA-2w4oA:
1.4
3svpB-2w4oA:
undetectable
3svpA-2w4oA:
20.26
3svpB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA


(Escherichia
coli)
PF00232
(Glyco_hydro_1)
4 PHE A  98
GLU A 108
ARG A 159
VAL A 164
None
1.46A 3svpA-2xhyA:
0.2
3svpB-2xhyA:
undetectable
3svpA-2xhyA:
20.63
3svpB-2xhyA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110)
4 PHE A 698
GLU A 722
ARG A 697
VAL A 717
None
1.31A 3svpA-2xvgA:
0.5
3svpB-2xvgA:
undetectable
3svpA-2xvgA:
19.68
3svpB-2xvgA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Thermus
thermophilus)
PF00117
(GATase)
PF00958
(GMP_synt_C)
4 PHE A 309
GLU A 305
ARG A 211
VAL A 239
None
1.30A 3svpA-2ywbA:
undetectable
3svpB-2ywbA:
undetectable
3svpA-2ywbA:
21.54
3svpB-2ywbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z11 RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE


(Thermus
thermophilus)
PF13302
(Acetyltransf_3)
4 TRP A  66
PHE A   4
GLU A   6
VAL A  64
None
1.41A 3svpA-2z11A:
undetectable
3svpB-2z11A:
undetectable
3svpA-2z11A:
17.58
3svpB-2z11A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT


(Cupriavidus
pinatubonensis)
no annotation 4 TRP A 374
GLU A 372
VAL A 314
TRP A 293
None
EDO  A 404 ( 3.8A)
None
None
1.44A 3svpA-3b7fA:
undetectable
3svpB-3b7fA:
undetectable
3svpA-3b7fA:
20.87
3svpB-3b7fA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16


(Saccharomyces
cerevisiae)
PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob)
4 TRP A 147
PHE A 117
ARG A 105
VAL A  35
None
1.50A 3svpA-3bitA:
undetectable
3svpB-3bitA:
undetectable
3svpA-3bitA:
23.51
3svpB-3bitA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber)
PF01036
(Bac_rhodopsin)
4 TRP A  70
PHE A  88
GLU A  71
VAL A  16
None
1.48A 3svpA-3ddlA:
undetectable
3svpB-3ddlA:
undetectable
3svpA-3ddlA:
20.14
3svpB-3ddlA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE


(Desulfovibrio
gigas)
PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9)
4 TRP B  88
GLU A 380
ARG A  66
VAL A 387
None
1.25A 3svpA-3gyxB:
undetectable
3svpB-3gyxB:
undetectable
3svpA-3gyxB:
16.67
3svpB-3gyxB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Toxoplasma
gondii)
PF00069
(Pkinase)
4 TRP A 257
PHE A 252
ARG A 269
VAL A 260
None
1.43A 3svpA-3ma6A:
undetectable
3svpB-3ma6A:
undetectable
3svpA-3ma6A:
21.55
3svpB-3ma6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8


(Homo sapiens)
PF00443
(UCH)
4 TRP A1001
PHE A 946
GLU A 908
ARG A 944
None
1.45A 3svpA-3n3kA:
undetectable
3svpB-3n3kA:
undetectable
3svpA-3n3kA:
19.83
3svpB-3n3kA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ner CYTOCHROME B5 TYPE B

(Homo sapiens)
PF00173
(Cyt-b5)
4 PHE A  58
GLU A  56
ARG A  68
VAL A  61
HEM  A 201 (-4.7A)
None
None
HEM  A 201 (-4.5A)
1.46A 3svpA-3nerA:
undetectable
3svpB-3nerA:
undetectable
3svpA-3nerA:
14.93
3svpB-3nerA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00583
(Acetyltransf_1)
4 PHE A 121
GLU A 119
ARG A 175
VAL A  92
None
1.23A 3svpA-3owcA:
undetectable
3svpB-3owcA:
1.6
3svpA-3owcA:
16.47
3svpB-3owcA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A


(Fervidobacterium
nodosum)
PF00150
(Cellulase)
4 TRP A 146
PHE A 162
GLU A 187
VAL A 149
None
1.27A 3svpA-3rjyA:
1.4
3svpB-3rjyA:
1.4
3svpA-3rjyA:
21.27
3svpB-3rjyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
4 PHE A 305
GLU A 265
VAL A 240
TRP A 239
None
1.34A 3svpA-3ti8A:
undetectable
3svpB-3ti8A:
undetectable
3svpA-3ti8A:
22.64
3svpB-3ti8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxm THYMIDYLATE KINASE

(Pseudomonas
aeruginosa)
PF02223
(Thymidylate_kin)
4 PHE A 162
GLU A 156
ARG A 109
VAL A 166
None
MG  A 213 (-3.2A)
None
None
1.32A 3svpA-3uxmA:
0.8
3svpB-3uxmA:
undetectable
3svpA-3uxmA:
20.29
3svpB-3uxmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8


(Saccharomyces
cerevisiae)
PF08084
(PROCT)
4 TRP C2314
PHE C2329
GLU C2310
VAL C2274
None
1.31A 3svpA-4bgdC:
undetectable
3svpB-4bgdC:
undetectable
3svpA-4bgdC:
20.99
3svpB-4bgdC:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d8o ANKYRIN-2

(Homo sapiens)
PF00531
(Death)
PF00791
(ZU5)
4 PHE A1118
GLU A1032
ARG A1065
VAL A1046
None
1.40A 3svpA-4d8oA:
undetectable
3svpB-4d8oA:
undetectable
3svpA-4d8oA:
19.44
3svpB-4d8oA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 PHE B 327
GLU B 424
VAL B 351
TRP B 355
None
1.09A 3svpA-4l37B:
undetectable
3svpB-4l37B:
undetectable
3svpA-4l37B:
20.69
3svpB-4l37B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli)
no annotation 4 PHE A 264
GLU A 266
ARG A 276
VAL A 305
None
1.22A 3svpA-4xj6A:
undetectable
3svpB-4xj6A:
undetectable
3svpA-4xj6A:
21.06
3svpB-4xj6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli)
no annotation 4 TRP A 263
PHE A 264
GLU A 266
VAL A 305
None
1.10A 3svpA-4xj6A:
undetectable
3svpB-4xj6A:
undetectable
3svpA-4xj6A:
21.06
3svpB-4xj6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7


(Homo sapiens)
PF03133
(TTL)
4 PHE A 277
GLU A 279
VAL A 288
TRP A 292
None
1.42A 3svpA-4ylrA:
undetectable
3svpB-4ylrA:
undetectable
3svpA-4ylrA:
22.81
3svpB-4ylrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2


(Eremothecium
gossypii)
PF10345
(Cohesin_load)
no annotation
4 TRP A 401
PHE A 397
GLU A 402
VAL B  28
None
1.50A 3svpA-5c6gA:
3.5
3svpB-5c6gA:
undetectable
3svpA-5c6gA:
21.86
3svpB-5c6gA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE


(Cosenzaea
myxofaciens)
PF01266
(DAO)
4 GLU A 418
ARG A 316
VAL A 438
TRP A 439
None
BE2  A1476 (-4.0A)
BE2  A1476 ( 4.3A)
BE2  A1476 ( 3.7A)
1.37A 3svpA-5fjnA:
undetectable
3svpB-5fjnA:
undetectable
3svpA-5fjnA:
23.27
3svpB-5fjnA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei)
PF00141
(peroxidase)
4 TRP A 736
PHE A 732
GLU A 560
VAL A 481
None
1.50A 3svpA-5kqiA:
undetectable
3svpB-5kqiA:
undetectable
3svpA-5kqiA:
20.85
3svpB-5kqiA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE


(Homo sapiens)
PF00264
(Tyrosinase)
4 TRP A 414
PHE A 411
GLU A 413
ARG A 225
None
1.07A 3svpA-5m8tA:
undetectable
3svpB-5m8tA:
undetectable
3svpA-5m8tA:
20.00
3svpB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgp SECRETED XWNT8
INHIBITOR SIZZLED


(Xenopus laevis)
PF01392
(Fz)
4 PHE A 180
GLU A 222
VAL A 254
TRP A 224
None
0.88A 3svpA-5xgpA:
undetectable
3svpB-5xgpA:
undetectable
3svpA-5xgpA:
19.67
3svpB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79


(Oryza sativa)
no annotation 4 GLU A 322
ARG A 331
VAL A 317
TRP A 316
None
None
UDP  A 501 ( 4.8A)
None
1.25A 3svpA-6bk1A:
undetectable
3svpB-6bk1A:
undetectable
3svpA-6bk1A:
13.48
3svpB-6bk1A:
13.48