SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUF_D_SUED1201_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b0k | PROTEIN (ACONITASE) (Sus scrofa) |
PF00330(Aconitase)PF00694(Aconitase_C) | 5 | VAL A 159GLY A 176VAL A 43ILE A 146ALA A 70 | None | 0.90A | 3sufD-1b0kA:undetectable | 3sufD-1b0kA:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxz | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 179VAL A 204ILE A 262GLY A 158ALA A 171 | None | 0.89A | 3sufD-1bxzA:undetectable | 3sufD-1bxzA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c8b | SPORE PROTEASE (Bacillusmegaterium) |
PF03418(Peptidase_A25) | 5 | VAL A 563GLY A 565ILE A 742ALA A 534ALA A 746 | None | 0.94A | 3sufD-1c8bA:undetectable | 3sufD-1c8bA:18.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1cu1 | PROTEIN(PROTEASE/HELICASENS3) (Hepacivirus C) |
PF02907(Peptidase_S29)PF07652(Flavi_DEAD) | 11 | VAL A 55HIS A 57GLY A 58VAL A 78ASP A 81GLY A 137SER A 139PHE A 154ALA A 156ALA A 157CYH A 159 | None | 0.53A | 3sufD-1cu1A:32.6 | 3sufD-1cu1A:81.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpe | PROTEIN (GLUCOSEOXIDASE) (Penicilliumamagasakiense) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | GLY A 388ILE A 442GLY A 327SER A 439ALA A 453 | None | 0.96A | 3sufD-1gpeA:undetectable | 3sufD-1gpeA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3m | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATECYTIDYLYLTRANSFERASE (Escherichiacoli) |
PF01128(IspD) | 5 | ILE A 56GLY A 92SER A 88ALA A 15ALA A 14 | None | 1.01A | 3sufD-1h3mA:undetectable | 3sufD-1h3mA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i9a | ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE (Escherichiacoli) |
PF00293(NUDIX) | 5 | HIS A 69GLY A 68VAL A 117ALA A 24ALA A 23 | MN A1001 (-3.1A)NoneNoneNoneNone | 0.78A | 3sufD-1i9aA:undetectable | 3sufD-1i9aA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jji | CARBOXYLESTERASE (Archaeoglobusfulgidus) |
PF07859(Abhydrolase_3) | 5 | GLY A 163VAL A 83GLY A 261ALA A 247ALA A 275 | None | 0.98A | 3sufD-1jjiA:undetectable | 3sufD-1jjiA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfw | CHITINASE B (Arthrobactersp. TAD20) |
PF00704(Glyco_hydro_18) | 5 | GLY A 195ILE A 58GLY A 204ALA A 146ALA A 145 | None | 0.97A | 3sufD-1kfwA:undetectable | 3sufD-1kfwA:16.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 7 | HIS A 57GLY A 58GLY A 137SER A 139PHE A 154ALA A 156CYH A 159 | None | 0.91A | 3sufD-1ns3A:29.1 | 3sufD-1ns3A:78.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 8 | HIS A 57GLY A 58VAL A 78GLY A 137SER A 139PHE A 154ALA A 156ALA A 157 | None | 0.82A | 3sufD-1ns3A:29.1 | 3sufD-1ns3A:78.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 8 | VAL A 55HIS A 57GLY A 58ASP A 81GLY A 137PHE A 154ALA A 156CYH A 159 | None | 0.60A | 3sufD-1ns3A:29.1 | 3sufD-1ns3A:78.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 9 | VAL A 55HIS A 57GLY A 58VAL A 78ASP A 81GLY A 137PHE A 154ALA A 156ALA A 157 | None | 0.52A | 3sufD-1ns3A:29.1 | 3sufD-1ns3A:78.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9h | INVASIN (Yersiniaenterocolitica) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 131ILE A 171GLY A 158SER A 147ALA A 149 | None | 0.94A | 3sufD-1p9hA:undetectable | 3sufD-1p9hA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9h | INVASIN (Yersiniaenterocolitica) |
PF05658(YadA_head)PF05662(YadA_stalk) | 6 | GLY A 131VAL A 115ILE A 173SER A 147ALA A 156ALA A 172 | None | 1.49A | 3sufD-1p9hA:undetectable | 3sufD-1p9hA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q0u | BSTDEAD (Geobacillusstearothermophilus) |
PF00270(DEAD) | 5 | GLY A 166ILE A 111GLY A 135ALA A 79ALA A 85 | None | 1.01A | 3sufD-1q0uA:undetectable | 3sufD-1q0uA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1n | HYPOTHETICALZINC-TYPE ALCOHOLDEHYDROGENASE-LIKEPROTEIN IN PRE5-FET4INTERGENIC REGION (Saccharomycescerevisiae) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | VAL A 352GLY A 353VAL A 333ILE A 149ALA A 159ALA A 158 | None | 1.28A | 3sufD-1q1nA:undetectable | 3sufD-1q1nA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tnu | GERANYLGERANYLTRANSFERASE TYPE IBETA SUBUNIT (Rattusnorvegicus) |
PF00432(Prenyltrans) | 5 | VAL B 340ILE B 227GLY B 277ALA B 343ALA B 228 | None | 0.90A | 3sufD-1tnuB:undetectable | 3sufD-1tnuB:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tvz | 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE (Staphylococcusaureus) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 5 | VAL A 273GLY A 154ILE A 136GLY A 279ALA A 58 | None | 0.98A | 3sufD-1tvzA:undetectable | 3sufD-1tvzA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uc4 | DIOL DEHYDRASE BETASUBUNIT (Klebsiellaoxytoca) |
PF02288(Dehydratase_MU) | 6 | GLY B 120VAL B 113ILE B 100GLY B 125ALA B 172ALA B 173 | NoneCNC B2601 (-4.9A)NoneNoneNoneNone | 1.42A | 3sufD-1uc4B:undetectable | 3sufD-1uc4B:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ur1 | ENDOXYLANASE (Cellvibriomixtus) |
PF00331(Glyco_hydro_10) | 5 | GLY A 229VAL A 154ASP A 153SER A 262ALA A 39 | NoneNoneNoneXYS A1376 (-3.4A)None | 1.02A | 3sufD-1ur1A:undetectable | 3sufD-1ur1A:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vtk | THYMIDINE KINASE (Humanalphaherpesvirus1) |
PF00693(Herpes_TK) | 5 | VAL A 314ILE A 235GLY A 240ALA A 174ALA A 175 | None | 1.01A | 3sufD-1vtkA:undetectable | 3sufD-1vtkA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z2i | MALATE DEHYDROGENASE (Agrobacteriumtumefaciens) |
PF02615(Ldh_2) | 5 | VAL A 62ILE A 120GLY A 273ALA A 93ALA A 90 | None | 1.00A | 3sufD-1z2iA:undetectable | 3sufD-1z2iA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zrt | CYTOCHROME BCYTOCHROME C1 (Rhodobactercapsulatus) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B)PF02167(Cytochrom_C1) | 5 | ASP C 278ILE D 131GLY D 126ALA D 106ALA D 104 | NoneHEC D 501 ( 4.9A)NoneNoneNone | 0.97A | 3sufD-1zrtC:undetectable | 3sufD-1zrtC:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0o | DIOLDEHYDRATASE-REACTIVATING FACTOR LARGESUBUNIT (Klebsiellaoxytoca) |
PF08841(DDR) | 5 | GLY A 346VAL A 341ILE A 231ALA A 237ALA A 235 | None | 1.02A | 3sufD-2d0oA:undetectable | 3sufD-2d0oA:14.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fp7 | GENOME POLYPROTEIN (West Nile virus) |
PF00949(Peptidase_S7) | 5 | HIS B 51VAL B 72ASP B 75GLY B 133SER B 135 | None | 0.85A | 3sufD-2fp7B:12.4 | 3sufD-2fp7B:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftw | DIHYDROPYRIMIDINEAMIDOHYDROLASE (Dictyosteliumdiscoideum) |
PF01979(Amidohydro_1) | 5 | HIS A 420VAL A 79ASP A 80ILE A 357GLY A 92 | None | 0.93A | 3sufD-2ftwA:undetectable | 3sufD-2ftwA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftw | DIHYDROPYRIMIDINEAMIDOHYDROLASE (Dictyosteliumdiscoideum) |
PF01979(Amidohydro_1) | 5 | HIS A 420VAL A 79ILE A 357GLY A 92ALA A 273 | None | 0.89A | 3sufD-2ftwA:undetectable | 3sufD-2ftwA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggv | NON-STRUCTURALPROTEIN 3 (West Nile virus) |
PF00949(Peptidase_S7) | 5 | VAL B 72ASP B 75ILE B 162ALA B 164ALA B 125 | None | 1.02A | 3sufD-2ggvB:12.1 | 3sufD-2ggvB:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4r | EXOPOLYPHOSPHATASE (Aquifexaeolicus) |
PF02541(Ppx-GppA) | 5 | HIS A 232GLY A 233GLY A 208ALA A 126ALA A 123 | None | 1.02A | 3sufD-2j4rA:undetectable | 3sufD-2j4rA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nn6 | POLYMYOSITIS/SCLERODERMA AUTOANTIGEN 1 (Homo sapiens) |
PF01138(RNase_PH)PF03725(RNase_PH_C) | 5 | GLY A 40VAL A 275ASP A 272ILE A 151GLY A 57 | None | 0.97A | 3sufD-2nn6A:undetectable | 3sufD-2nn6A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pnc | COPPER AMINEOXIDASE, LIVERISOZYME (Bos taurus) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3) | 5 | VAL A 351ASP A 350GLY A 115ALA A 108ALA A 107 | None | 1.00A | 3sufD-2pncA:undetectable | 3sufD-2pncA:13.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjp | CYTOCHROME BCYTOCHROME C1 (Rhodobactersphaeroides) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B)PF02167(Cytochrom_C1) | 5 | ASP A 278ILE B 131GLY B 109ALA B 106ALA B 104 | NoneHEM B 301 ( 4.3A)NoneNoneNone | 0.85A | 3sufD-2qjpA:undetectable | 3sufD-2qjpA:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uvd | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Bacillusanthracis) |
PF13561(adh_short_C2) | 5 | GLY A 81ASP A 84ILE A 49ALA A 29ALA A 25 | None | 0.99A | 3sufD-2uvdA:undetectable | 3sufD-2uvdA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhl | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 5 | VAL A 249HIS A 220ILE A 353ALA A 347ALA A 348 | None | 0.88A | 3sufD-2vhlA:undetectable | 3sufD-2vhlA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vid | SERINE PROTEASE SPLB (Staphylococcusaureus) |
PF00089(Trypsin) | 5 | HIS A 39ASP A 77GLY A 155SER A 157ALA A 174 | None | 0.93A | 3sufD-2vidA:6.5 | 3sufD-2vidA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2whx | SERINEPROTEASE/NTPASE/HELICASE NS3 (Dengue virus) |
PF00949(Peptidase_S7)PF07652(Flavi_DEAD) | 5 | HIS A 51VAL A 72ASP A 75GLY A 133SER A 135 | None | 0.72A | 3sufD-2whxA:11.6 | 3sufD-2whxA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xmo | LMO2642 PROTEIN (Listeriamonocytogenes) |
PF00149(Metallophos) | 5 | HIS A 243GLY A 133VAL A 48ASP A 47GLY A 214 | FE A 556 (-3.4A)NoneNone MN A 555 (-3.2A)None | 0.98A | 3sufD-2xmoA:undetectable | 3sufD-2xmoA:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yh2 | ESTERASE (Pyrobaculumcalidifontis) |
PF07859(Abhydrolase_3) | 5 | GLY A 160VAL A 80GLY A 260ALA A 246ALA A 274 | None | 0.92A | 3sufD-2yh2A:undetectable | 3sufD-2yh2A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zkm | 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATEPHOSPHODIESTERASEBETA-2 (Homo sapiens) |
PF00168(C2)PF00387(PI-PLC-Y)PF00388(PI-PLC-X)PF09279(EF-hand_like) | 5 | VAL X 108ILE X 763GLY X 760SER X 780ALA X 640 | None | 0.96A | 3sufD-2zkmX:undetectable | 3sufD-2zkmX:13.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a5v | ALPHA-GALACTOSIDASE (Umbelopsisvinacea) |
PF16499(Melibiase_2) | 5 | GLY A 271ILE A 83GLY A 12ALA A 31ALA A 32 | None | 1.02A | 3sufD-3a5vA:undetectable | 3sufD-3a5vA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ak5 | HEMOGLOBIN-BINDINGPROTEASE HBP (Escherichiacoli) |
PF02395(Peptidase_S6) | 5 | VAL A 123HIS A 125ASP A 153GLY A 257ALA A 281 | None | 0.55A | 3sufD-3ak5A:6.8 | 3sufD-3ak5A:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3p | METHYLTRANSFERASE (Geobactersulfurreducens) |
PF01596(Methyltransf_3) | 5 | GLY A 164ASP A 132ILE A 195GLY A 199ALA A 157 | None | 0.93A | 3sufD-3c3pA:undetectable | 3sufD-3c3pA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cdi | POLYNUCLEOTIDEPHOSPHORYLASE (Escherichiacoli) |
PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 6 | VAL A 212ILE A 556GLY A 551ALA A 519ALA A 485CYH A 467 | None | 1.23A | 3sufD-3cdiA:undetectable | 3sufD-3cdiA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e9n | PUTATIVE SHORT-CHAINDEHYDROGENASE/REDUCTASE (Corynebacteriumglutamicum) |
PF00106(adh_short) | 5 | VAL A 20GLY A 16GLY A 33ALA A 41ALA A 40 | None | 1.00A | 3sufD-3e9nA:undetectable | 3sufD-3e9nA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3exs | RMPD(HEXULOSE-6-PHOSPHATE SYNTHASE) (Streptococcusmutans) |
PF00215(OMPdecase) | 5 | VAL A 44GLY A 45ILE A 34GLY A 37ALA A 24 | None | 1.00A | 3sufD-3exsA:undetectable | 3sufD-3exsA:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7n | LIPASE (Penicilliumexpansum) |
PF01764(Lipase_3) | 6 | HIS A 241VAL A 186ASP A 188PHE A 162ALA A 161ALA A 136 | SO4 A 259 ( 4.6A)NoneNoneNoneNoneNone | 1.17A | 3sufD-3g7nA:undetectable | 3sufD-3g7nA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcw | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 5 | HIS A 226ASP A 186GLY A 384SER A 386ALA A 290 | None | 0.82A | 3sufD-3gcwA:undetectable | 3sufD-3gcwA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gme | POLYRIBONUCLEOTIDENUCLEOTIDYLTRANSFERASE (Escherichiacoli) |
PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 5 | ILE A 533GLY A 528ALA A 496ALA A 462CYH A 444 | None | 0.98A | 3sufD-3gmeA:undetectable | 3sufD-3gmeA:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvc | PROBABLE SHORT-CHAINTYPEDEHYDROGENASE/REDUCTASE (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 5 | VAL A 98GLY A 102ILE A 198ALA A 145ALA A 146 | None | 1.01A | 3sufD-3gvcA:undetectable | 3sufD-3gvcA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ip1 | ALCOHOLDEHYDROGENASE,ZINC-CONTAINING (Thermotogamaritima) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | HIS A 95GLY A 94VAL A 155ILE A 223SER A 68 | CD A 501 (-3.4A)NoneNoneNone CD A 501 ( 3.7A) | 0.98A | 3sufD-3ip1A:undetectable | 3sufD-3ip1A:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kd6 | CARBOHYDRATE KINASE,PFKB FAMILY (Chlorobaculumtepidum) |
PF00294(PfkB) | 6 | GLY A 48ILE A 244GLY A 124SER A 29ALA A 33ALA A 36 | None | 1.29A | 3sufD-3kd6A:undetectable | 3sufD-3kd6A:23.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mde | MEDIUM CHAINACYL-COADEHYDROGENASE (Sus scrofa) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ILE A 77GLY A 322ALA A 315ALA A 316CYH A 81 | None | 1.01A | 3sufD-3mdeA:undetectable | 3sufD-3mdeA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qka | ENOYL-COA HYDRATASE,ECHA5 (Mycobacteriummarinum) |
PF00378(ECH_1) | 5 | GLY A 57SER A 101ALA A 99ALA A 98CYH A 115 | None | 0.89A | 3sufD-3qkaA:undetectable | 3sufD-3qkaA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qr3 | ENDOGLUCANASE EG-II (Trichodermareesei) |
PF00150(Cellulase) | 5 | GLY A 91VAL A 141GLY A 45PHE A 50ALA A 294 | None | 0.89A | 3sufD-3qr3A:undetectable | 3sufD-3qr3A:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rim | TRANSKETOLASE (Mycobacteriumtuberculosis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | GLY A 461ILE A 515GLY A 547ALA A 478ALA A 479 | None | 0.81A | 3sufD-3rimA:undetectable | 3sufD-3rimA:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s29 | SUCROSE SYNTHASE 1 (Arabidopsisthaliana) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 5 | HIS A 287GLY A 288ASP A 417GLY A 302ALA A 439 | FRU A 902 (-4.0A)NoneNoneFRU A 902 ( 2.2A)FRU A 902 ( 3.7A) | 0.93A | 3sufD-3s29A:undetectable | 3sufD-3s29A:12.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3stj | PROTEASE DEGQ (Escherichiacoli) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | HIS A 82ASP A 112GLY A 185SER A 187ALA A 204 | None | 0.68A | 3sufD-3stjA:13.2 | 3sufD-3stjA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u1j | SERINE PROTEASE NS3 (Dengue virus) |
PF00949(Peptidase_S7) | 5 | HIS B 51VAL B 72ASP B 75GLY B 133SER B 135 | None | 0.83A | 3sufD-3u1jB:12.8 | 3sufD-3u1jB:23.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ufa | SERINE PROTEASE SPLA (Staphylococcusaureus) |
PF00089(Trypsin) | 5 | HIS A 39ASP A 78GLY A 152SER A 154ALA A 171 | VPF A 201 (-3.8A)NoneVPF A 201 (-3.3A)VPF A 201 (-1.7A)VPF A 201 (-4.9A) | 0.78A | 3sufD-3ufaA:11.5 | 3sufD-3ufaA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v2g | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | GLY A 108ASP A 111ILE A 76ALA A 56ALA A 52 | None | 1.01A | 3sufD-3v2gA:undetectable | 3sufD-3v2gA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vex | O-CARBAMOYLTRANSFERASE TOBZ (Streptoalloteichustenebrarius) |
PF02543(Carbam_trans_N)PF16861(Carbam_trans_C) | 5 | GLY A 140VAL A 161GLY A 70ALA A 119ALA A 120 | CA0 A 602 ( 4.9A)NoneNoneNoneNone | 0.98A | 3sufD-3vexA:undetectable | 3sufD-3vexA:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vov | GLUCOKINASE (Thermusthermophilus) |
PF00480(ROK) | 5 | VAL A 141GLY A 143GLY A 239SER A 127ALA A 120 | None | 1.00A | 3sufD-3vovA:undetectable | 3sufD-3vovA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wbn | PUTATIVEUNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF01554(MatE) | 6 | VAL A 425GLY A 424VAL A 430ILE A 358GLY A 271ALA A 277 | None | 1.28A | 3sufD-3wbnA:undetectable | 3sufD-3wbnA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 6 | GLY A 241GLY A 150SER A 153PHE A 296ALA A 300CYH A 304 | None | 1.47A | 3sufD-4a01A:undetectable | 3sufD-4a01A:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fbl | LIPS LIPOLYTICENZYME (unidentified) |
PF12146(Hydrolase_4) | 5 | VAL A 230HIS A 257ASP A 227GLY A 57SER A 126 | NoneSPD A 301 (-3.2A)NoneSPD A 301 (-3.5A)SPD A 301 ( 2.3A) | 1.01A | 3sufD-4fblA:undetectable | 3sufD-4fblA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fln | PROTEASE DO-LIKE 2,CHLOROPLASTIC (Arabidopsisthaliana) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | HIS A 159VAL A 187ASP A 190GLY A 266SER A 268 | None | 0.53A | 3sufD-4flnA:12.0 | 3sufD-4flnA:18.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fx5 | VON WILLEBRANDFACTOR TYPE A (Catenulisporaacidiphila) |
PF13768(VWA_3) | 5 | GLY A 284ILE A 179GLY A 184PHE A 186ALA A 188 | None | 0.93A | 3sufD-4fx5A:undetectable | 3sufD-4fx5A:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h09 | HYPOTHETICAL LEUCINERICH REPEAT PROTEIN (Eubacteriumventriosum) |
PF13306(LRR_5) | 5 | GLY A 185ILE A 253GLY A 247SER A 245ALA A 266 | None | 0.96A | 3sufD-4h09A:undetectable | 3sufD-4h09A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h6w | N-TERMINALCYANOBACTIN PROTEASE (Planktothrixagardhii) |
PF00082(Peptidase_S8) | 5 | HIS A 61ASP A 26GLY A 219SER A 221ALA A 123 | None | 0.95A | 3sufD-4h6wA:undetectable | 3sufD-4h6wA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h6w | N-TERMINALCYANOBACTIN PROTEASE (Planktothrixagardhii) |
PF00082(Peptidase_S8) | 5 | VAL A 65HIS A 61ASP A 26GLY A 219ALA A 123 | None | 0.76A | 3sufD-4h6wA:undetectable | 3sufD-4h6wA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iig | BETA-GLUCOSIDASE 1 (Aspergillusaculeatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | GLY A 38GLY A 272SER A 752ALA A 239ALA A 236 | None | 0.97A | 3sufD-4iigA:undetectable | 3sufD-4iigA:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inl | SERINE PROTEASE SPLD (Staphylococcusaureus) |
PF13365(Trypsin_2) | 5 | HIS A 39ASP A 78GLY A 154SER A 156ALA A 173 | None | 0.67A | 3sufD-4inlA:8.7 | 3sufD-4inlA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iox | TRIPARTITE TERMINASESUBUNIT UL15 (Humanalphaherpesvirus1) |
PF02499(DNA_pack_C) | 5 | VAL A 508GLY A 522VAL A 525ALA A 555ALA A 552 | NoneNoneNoneNonePEG A 802 ( 3.9A) | 1.02A | 3sufD-4ioxA:undetectable | 3sufD-4ioxA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ix3 | MSSTT7D PROTEIN (Micromonascommoda) |
PF00069(Pkinase) | 5 | ASP A 338GLY A 359ALA A 342ALA A 343CYH A 345 | MG A 601 (-2.6A)NoneNoneNoneNone | 0.99A | 3sufD-4ix3A:undetectable | 3sufD-4ix3A:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlw | GLUTATHIONE-INDEPENDENT FORMALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | GLY A 48VAL A 389ILE A 192GLY A 301ALA A 201ALA A 202 | NAD A 403 (-3.0A)NoneNoneNAD A 403 ( 3.7A)NoneNone | 1.41A | 3sufD-4jlwA:undetectable | 3sufD-4jlwA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k29 | ENOYL-COAHYDRATASE/ISOMERASE (Xanthobacterautotrophicus) |
PF00378(ECH_1) | 6 | GLY A 58ASP A 189GLY A 108ALA A 105ALA A 104CYH A 121 | None | 1.43A | 3sufD-4k29A:undetectable | 3sufD-4k29A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kzp | OXIDOREDUCTASE,SHORT CHAINDEHYDROGENASE/REDUCTASE FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF00106(adh_short) | 5 | GLY A 98ASP A 101ILE A 67ALA A 47ALA A 43 | None | 0.97A | 3sufD-4kzpA:undetectable | 3sufD-4kzpA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m88 | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Verminephrobactereiseniae) |
PF13458(Peripla_BP_6) | 5 | VAL A 101GLY A 100GLY A 288ALA A 18ALA A 19 | None | 1.01A | 3sufD-4m88A:undetectable | 3sufD-4m88A:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mzd | NISIN LEADERPEPTIDE-PROCESSINGSERINE PROTEASE NISP (Lactococcuslactis) |
PF00082(Peptidase_S8) | 5 | VAL A 310HIS A 306ASP A 259GLY A 510ALA A 364 | None | 0.83A | 3sufD-4mzdA:undetectable | 3sufD-4mzdA:17.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nwk | HCV NS3 1A PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 6 | HIS A 57GLY A 58ILE A 132GLY A 137PHE A 154CYH A 159 | 2R8 A 301 (-3.3A)2R8 A 301 (-3.5A)2R8 A 301 (-4.3A)GOL A 305 ( 3.2A)2R8 A 301 (-3.7A)None | 0.77A | 3sufD-4nwkA:32.3 | 3sufD-4nwkA:99.49 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nwk | HCV NS3 1A PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 11 | VAL A 55HIS A 57GLY A 58VAL A 78ASP A 81ILE A 132GLY A 137SER A 139PHE A 154ALA A 156ALA A 157 | None2R8 A 301 (-3.3A)2R8 A 301 (-3.5A)None2R8 A 301 (-3.6A)2R8 A 301 (-4.3A)GOL A 305 ( 3.2A)2R8 A 301 (-2.6A)2R8 A 301 (-3.7A)2R8 A 301 (-3.1A)2R8 A 301 (-3.8A) | 0.69A | 3sufD-4nwkA:32.3 | 3sufD-4nwkA:99.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4om9 | SERINE PROTEASE PET (Escherichiacoli) |
PF02395(Peptidase_S6) | 5 | VAL A 70HIS A 72ASP A 101GLY A 206SER A 208 | None | 0.85A | 3sufD-4om9A:4.9 | 3sufD-4om9A:12.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ov6 | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 5 | HIS B 226ASP B 186GLY B 384SER B 386ALA B 290 | None | 0.82A | 3sufD-4ov6B:undetectable | 3sufD-4ov6B:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r4z | PNGF-II (Elizabethkingiameningoseptica) |
PF09112(N-glycanase_N)PF09113(N-glycanase_C) | 5 | ASP A 354ILE A 315GLY A 309SER A 240ALA A 244 | None | 0.91A | 3sufD-4r4zA:undetectable | 3sufD-4r4zA:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rbn | SUCROSESYNTHASE:GLYCOSYLTRANSFERASES GROUP 1 (Nitrosomonaseuropaea) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 5 | HIS A 273GLY A 274ASP A 404GLY A 288ALA A 426 | None | 0.90A | 3sufD-4rbnA:undetectable | 3sufD-4rbnA:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tr2 | SUBTILISIN-LIKE 1SERINE PROTEASE (Plasmodiumvivax) |
PF00082(Peptidase_S8) | 5 | HIS A 372ASP A 316GLY A 547SER A 549ALA A 201 | None | 0.99A | 3sufD-4tr2A:undetectable | 3sufD-4tr2A:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4woe | TAUROCYAMINE KINASE (Schistosomamansoni) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 5 | HIS A 311GLY A 309ILE A 284GLY A 306ALA A 282 | None | 0.94A | 3sufD-4woeA:undetectable | 3sufD-4woeA:16.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x2x | NS6 PROTEASE (Norwalk virus) |
PF05416(Peptidase_C37) | 5 | HIS A 30ASP A 54GLY A 137ALA A 159ALA A 160 | None | 0.65A | 3sufD-4x2xA:10.0 | 3sufD-4x2xA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0m | ENOYL-COA HYDRATASE (Mycobacteriumtuberculosis) |
PF00378(ECH_1) | 5 | GLY A 57SER A 101ALA A 99ALA A 98CYH A 115 | None | 0.91A | 3sufD-4z0mA:undetectable | 3sufD-4z0mA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zzp | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Dictyosteliumpurpureum) |
PF00840(Glyco_hydro_7) | 5 | VAL A 323GLY A 325ILE A 331GLY A 328SER A 321 | None | 1.01A | 3sufD-4zzpA:undetectable | 3sufD-4zzpA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dds | CRMG (Actinoalloteichussp. WH1-2216-6) |
PF00202(Aminotran_3) | 5 | VAL A 314GLY A 337GLY A 334SER A 330ALA A 326 | None | 0.97A | 3sufD-5ddsA:undetectable | 3sufD-5ddsA:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dzs | SHIKIMATEDEHYDROGENASE(NADP(+)) (Clostridioidesdifficile) |
PF08501(Shikimate_dh_N) | 6 | VAL A 116GLY A 141VAL A 120ILE A 82ALA A 133ALA A 132 | None | 1.24A | 3sufD-5dzsA:undetectable | 3sufD-5dzsA:21.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eqq | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 11 | VAL A1055HIS A1057GLY A1058VAL A1078ASP A1081ILE A1132GLY A1137PHE A1154ALA A1156ALA A1157CYH A1159 | None5RS A1203 (-2.5A)5RS A1203 ( 2.9A)5RS A1203 (-3.9A)5RS A1203 (-3.5A)5RS A1203 ( 4.1A)5RS A1203 (-3.2A)5RS A1203 (-3.3A)5RS A1203 (-2.9A)5RS A1203 (-3.5A)5RS A1203 ( 3.5A) | 0.51A | 3sufD-5eqqA:32.7 | 3sufD-5eqqA:94.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fji | BETA-GLUCOSIDASE (Aspergillusfumigatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | HIS A 550VAL A 502GLY A 576SER A 579ALA A 398 | None | 0.99A | 3sufD-5fjiA:undetectable | 3sufD-5fjiA:14.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gj4 | SERINE PROTEASE NS3 (Zika virus) |
PF00949(Peptidase_S7) | 5 | HIS B 51VAL B 72ASP B 75GLY B 133SER B 135 | None | 0.77A | 3sufD-5gj4B:12.6 | 3sufD-5gj4B:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gxj | FLAVIVIRUS_NS2B,LINKER,PEPTIDASE S7 (Zika virus;syntheticconstruct) |
PF00949(Peptidase_S7)PF01002(Flavi_NS2B) | 5 | HIS A1051VAL A1072ASP A1075GLY A1133SER A1135 | None | 0.86A | 3sufD-5gxjA:11.1 | 3sufD-5gxjA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9x | BETA-1,3-GLUCANASE (Paenibacillusbarengoltzii) |
PF16483(Glyco_hydro_64) | 5 | HIS A 384GLY A 390GLY A 402ALA A 351CYH A 350 | None | 0.99A | 3sufD-5h9xA:undetectable | 3sufD-5h9xA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idk | GENOMEPOLYPROTEIN,SERINEPROTEASE SUBUNITNS2B, SERINEPROTEASE NS3 (West Nile virus) |
PF00949(Peptidase_S7)PF01002(Flavi_NS2B) | 5 | HIS A1051VAL A1072ASP A1075GLY A1133SER A1135 | 6A8 A1201 (-3.3A)None6A8 A1201 ( 4.2A)6A8 A1201 (-3.4A)6A8 A1201 (-1.5A) | 0.96A | 3sufD-5idkA:11.9 | 3sufD-5idkA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ilb | PROTEASE DO-LIKE 2,CHLOROPLASTIC,PROTEASE DO-LIKE 9 (Arabidopsisthaliana) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | HIS A 159VAL A 187ASP A 190GLY A 266SER A 268 | None | 0.83A | 3sufD-5ilbA:13.0 | 3sufD-5ilbA:18.49 |