SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUF_C_SUEC1201
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a8q | BROMOPEROXIDASE A1 (Kitasatosporaaureofaciens) |
PF00561(Abhydrolase_1) | 5 | HIS A 252ASP A 223GLY A 27SER A 94ALA A 255 | None | 1.05A | 3sufC-1a8qA:undetectable | 3sufC-1a8qA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cc1 | HYDROGENASE (LARGESUBUNIT) (Desulfomicrobiumbaculatum) |
PF00374(NiFeSe_Hases) | 5 | GLN L 111ASP L 490PHE L 117ALA L 121ALA L 122 | None | 1.18A | 3sufC-1cc1L:undetectable | 3sufC-1cc1L:17.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1cu1 | PROTEIN(PROTEASE/HELICASENS3) (Hepacivirus C) |
PF02907(Peptidase_S29)PF07652(Flavi_DEAD) | 11 | GLN A 41PHE A 43TYR A 56HIS A 57GLY A 58ASP A 81GLY A 137SER A 139PHE A 154ALA A 156ALA A 157 | None | 0.68A | 3sufC-1cu1A:34.0 | 3sufC-1cu1A:81.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dt2 | EXFOLIATIVE TOXIN B (Staphylococcusaureus) |
PF13365(Trypsin_2) | 5 | TYR A 64HIS A 65ASP A 114GLY A 184SER A 186 | None | 1.10A | 3sufC-1dt2A:9.9 | 3sufC-1dt2A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efp | PROTEIN (ELECTRONTRANSFERFLAVOPROTEIN) (Paracoccusdenitrificans) |
PF00766(ETF_alpha)PF01012(ETF) | 5 | GLN A 240HIS A 264GLY A 242GLY A 224ALA A 255 | FAD A 399 (-3.9A)FAD A 399 (-3.9A)FAD A 399 (-3.1A)NoneNone | 1.14A | 3sufC-1efpA:undetectable | 3sufC-1efpA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1efv | ELECTRON TRANSFERFLAVOPROTEIN (Homo sapiens) |
PF00766(ETF_alpha)PF01012(ETF) | 5 | GLN A 262HIS A 286GLY A 264GLY A 246ALA A 277 | FAD A 599 (-3.8A)FAD A 599 (-3.8A)FAD A 599 (-3.1A)NoneNone | 1.10A | 3sufC-1efvA:undetectable | 3sufC-1efvA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evq | SERINE HYDROLASE (Alicyclobacillusacidocaldarius) |
PF07859(Abhydrolase_3) | 5 | HIS A 282ASP A 252GLY A 82SER A 155ALA A 285 | EPE A 455 (-4.0A)NoneEPE A 455 (-3.5A)EPE A 455 (-1.4A)None | 1.11A | 3sufC-1evqA:undetectable | 3sufC-1evqA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eys | PHOTOSYNTHETICREACTION CENTER (Thermochromatiumtepidum) |
PF00124(Photo_RC) | 5 | PHE L 34GLY L 38SER L 107ALA L 102ALA L 101 | NoneNoneNoneNoneBPH L 606 ( 3.9A) | 1.19A | 3sufC-1eysL:undetectable | 3sufC-1eysL:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iyx | ENOLASE (Enterococcushirae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | TYR A 281GLY A 217GLY A 151ALA A 242ALA A 243 | NoneNoneNoneNone MG A1432 ( 4.8A) | 1.12A | 3sufC-1iyxA:undetectable | 3sufC-1iyxA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jsc | ACETOHYDROXY-ACIDSYNTHASE (Saccharomycescerevisiae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLN A 501GLY A 520ASP A 176ALA A 531ALA A 532 | NoneFAD A 701 ( 4.4A)NoneNoneNone | 1.11A | 3sufC-1jscA:undetectable | 3sufC-1jscA:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1j | HEAT SHOCK PROTEASEHTRA (Thermotogamaritima) |
PF13365(Trypsin_2) | 5 | TYR A 96HIS A 97ASP A 127GLY A 204SER A 206 | None | 0.94A | 3sufC-1l1jA:8.0 | 3sufC-1l1jA:23.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 10 | GLN A 41PHE A 43TYR A 56HIS A 57GLY A 58ASP A 81GLY A 137PHE A 154ALA A 156ALA A 157 | None | 0.66A | 3sufC-1ns3A:29.8 | 3sufC-1ns3A:78.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 6 | GLN A 41TYR A 56HIS A 57ASP A 81GLY A 137SER A 139 | None | 0.93A | 3sufC-1ns3A:29.8 | 3sufC-1ns3A:78.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p3c | GLUTAMYL-ENDOPEPTIDASE (Bacillusintermedius) |
PF00089(Trypsin) | 5 | HIS A 47ASP A 97GLY A 169SER A 171ALA A 188 | None | 0.81A | 3sufC-1p3cA:10.1 | 3sufC-1p3cA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p4t | OUTER MEMBRANEPROTEIN NSPA (Neisseriameningitidis) |
PF02462(Opacity) | 5 | TYR A 132GLY A 107GLY A 65ALA A 84ALA A 68 | CXE A 300 ( 4.8A)NoneNoneCXE A 400 ( 4.9A)CXE A 400 ( 3.8A) | 1.14A | 3sufC-1p4tA:undetectable | 3sufC-1p4tA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9h | INVASIN (Yersiniaenterocolitica) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 76GLY A 104SER A 93ALA A 95ALA A 109 | None | 1.05A | 3sufC-1p9hA:undetectable | 3sufC-1p9hA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9h | INVASIN (Yersiniaenterocolitica) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 90GLY A 118SER A 107ALA A 109ALA A 123 | None | 1.06A | 3sufC-1p9hA:undetectable | 3sufC-1p9hA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qlb | FUMARATE REDUCTASEFLAVOPROTEIN SUBUNIT (Wolinellasuccinogenes) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | TYR A 423GLY A 421GLY A 17ALA A 395ALA A 394 | None | 1.18A | 3sufC-1qlbA:undetectable | 3sufC-1qlbA:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1szn | ALPHA-GALACTOSIDASE (Trichodermareesei) |
PF16499(Melibiase_2) | 5 | GLY A 66ASP A 117GLY A 62ALA A 109ALA A 102 | None | 1.05A | 3sufC-1sznA:undetectable | 3sufC-1sznA:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vlj | NADH-DEPENDENTBUTANOLDEHYDROGENASE (Thermotogamaritima) |
PF00465(Fe-ADH) | 5 | TYR A 162GLY A 163GLY A 149ALA A 107ALA A 109 | None | 1.16A | 3sufC-1vljA:undetectable | 3sufC-1vljA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y8t | HYPOTHETICAL PROTEINRV0983 (Mycobacteriumtuberculosis) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | HIS A 49ASP A 88GLY A 167SER A 169ALA A 186 | None | 0.85A | 3sufC-1y8tA:12.4 | 3sufC-1y8tA:25.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a9f | PUTATIVE MALICENZYME((S)-MALATE:NAD+OXIDOREDUCTASE(DECARBOXYLATING)) (Streptococcuspyogenes) |
PF00390(malic)PF03949(Malic_M) | 5 | PHE A 286GLY A 309GLY A 264ALA A 289ALA A 267 | None | 1.08A | 3sufC-2a9fA:undetectable | 3sufC-2a9fA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bej | SEGREGATION PROTEIN (Thermusthermophilus) |
PF13614(AAA_31) | 5 | TYR A 112ASP A 109GLY A 136ALA A 133ALA A 132 | None | 1.17A | 3sufC-2bejA:undetectable | 3sufC-2bejA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c7b | CARBOXYLESTERASE (unculturedarchaeon) |
PF07859(Abhydrolase_3) | 5 | TYR A 79GLY A 157GLY A 257ALA A 243ALA A 271 | None | 1.15A | 3sufC-2c7bA:undetectable | 3sufC-2c7bA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ewy | BETA-SECRETASE 2 (Homo sapiens) |
PF00026(Asp) | 5 | TYR A 318GLY A 335GLY A 27SER A 26ALA A 173 | None | 1.13A | 3sufC-2ewyA:undetectable | 3sufC-2ewyA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isq | CYSTEINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 5 | GLY A 225GLY A 267PHE A 295ALA A 273ALA A 274 | PLP A 400 (-3.5A)NoneNoneNoneNone | 1.00A | 3sufC-2isqA:undetectable | 3sufC-2isqA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4r | EXOPOLYPHOSPHATASE (Aquifexaeolicus) |
PF02541(Ppx-GppA) | 5 | HIS A 232GLY A 233GLY A 208ALA A 126ALA A 123 | None | 1.10A | 3sufC-2j4rA:undetectable | 3sufC-2j4rA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jl4 | MALEYLPYRUVATEISOMERASE (Ralstonia sp.U2) |
PF13410(GST_C_2)PF13417(GST_N_3) | 5 | TYR A 154GLY A 157ASP A 164GLY A 88ALA A 94 | None | 1.17A | 3sufC-2jl4A:undetectable | 3sufC-2jl4A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o69 | IRON-UTILIZATIONPERIPLASMIC PROTEIN (Haemophilusinfluenzae) |
PF01547(SBP_bac_1) | 5 | TYR A 265GLY A 100GLY A 229ALA A 12ALA A 13 | None | 1.15A | 3sufC-2o69A:undetectable | 3sufC-2o69A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjt | NICOTINAMIDE-NUCLEOTIDEADENYLYLTRANSFERASE (Francisellatularensis) |
no annotation | 5 | HIS B 110GLY B 109ASP B 131GLY B 9ALA B 138 | None | 0.98A | 3sufC-2qjtB:undetectable | 3sufC-2qjtB:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vid | SERINE PROTEASE SPLB (Staphylococcusaureus) |
PF00089(Trypsin) | 5 | HIS A 39ASP A 77GLY A 155SER A 157ALA A 174 | None | 0.82A | 3sufC-2vidA:5.7 | 3sufC-2vidA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wge | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 1 (Mycobacteriumtuberculosis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 174GLY A 403SER A 401ALA A 410ALA A 290 | NoneTLM A1424 (-3.9A)NoneNoneNone | 1.13A | 3sufC-2wgeA:undetectable | 3sufC-2wgeA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xqh | IMMUNOGLOBULIN-BINDING PROTEIN EIBD (Escherichiacoli) |
PF05658(YadA_head) | 5 | GLY A 166GLY A 194SER A 183ALA A 185ALA A 199 | None | 1.09A | 3sufC-2xqhA:undetectable | 3sufC-2xqhA:24.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xr1 | CLEAVAGE ANDPOLYADENYLATIONSPECIFICITY FACTOR100 KD SUBUNIT (Methanosarcinamazei) |
PF07521(RMMBL)PF07650(KH_2)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 5 | TYR A 353HIS A 580ASP A 352GLY A 535PHE A 416 | NoneNone ZN A1639 ( 2.3A)NoneNone | 1.13A | 3sufC-2xr1A:undetectable | 3sufC-2xr1A:13.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yh2 | ESTERASE (Pyrobaculumcalidifontis) |
PF07859(Abhydrolase_3) | 5 | TYR A 82GLY A 160GLY A 260ALA A 246ALA A 274 | None | 1.17A | 3sufC-2yh2A:undetectable | 3sufC-2yh2A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z1k | (NEO)PULLULANASE (Thermusthermophilus) |
PF00128(Alpha-amylase) | 5 | GLN A 284PHE A 261GLY A 407GLY A 260ALA A 266 | None | 1.16A | 3sufC-2z1kA:undetectable | 3sufC-2z1kA:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z3t | CYTOCHROME P450 (Streptomycessp. TP-A0274) |
PF00067(p450) | 5 | GLN A 354PHE A 357GLY A 358ALA A 303ALA A 327 | NoneHEM A 500 (-4.5A)HEM A 500 (-3.7A)NoneNone | 1.20A | 3sufC-2z3tA:undetectable | 3sufC-2z3tA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsg | AMINOPEPTIDASE P,PUTATIVE (Thermotogamaritima) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | PHE A 38GLY A 40GLY A 37SER A 32ALA A 30 | None | 0.92A | 3sufC-2zsgA:undetectable | 3sufC-2zsgA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahi | XYLULOSE5-PHOSPHATE/FRUCTOSE6-PHOSPHATEPHOSPHOKETOLASE (Bifidobacteriumbreve) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 5 | GLY A 158GLY A 484SER A 162ALA A 164ALA A 167 | None | 1.17A | 3sufC-3ahiA:undetectable | 3sufC-3ahiA:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai7 | XYLULOSE-5-PHOSPHATE/FRUCTOSE-6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacteriumlongum) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 5 | GLY A 158GLY A 484SER A 162ALA A 164ALA A 167 | None | 1.19A | 3sufC-3ai7A:undetectable | 3sufC-3ai7A:13.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ak5 | HEMOGLOBIN-BINDINGPROTEASE HBP (Escherichiacoli) |
PF02395(Peptidase_S6) | 5 | HIS A 125ASP A 153GLY A 257SER A 259ALA A 281 | None | 0.77A | 3sufC-3ak5A:6.5 | 3sufC-3ak5A:13.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dme | CONSERVED EXPORTEDPROTEIN (Bordetellapertussis) |
PF01266(DAO) | 5 | PHE A 329GLY A 352GLY A 347ALA A 204ALA A 205 | NoneFAD A 500 (-3.1A)NoneNoneFAD A 500 (-3.6A) | 1.17A | 3sufC-3dmeA:undetectable | 3sufC-3dmeA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fcy | XYLAN ESTERASE 1 (Thermoanaerobacteriumsaccharolyticum) |
PF05448(AXE1) | 5 | PHE A 207HIS A 301ASP A 272GLY A 90SER A 182 | None | 1.05A | 3sufC-3fcyA:undetectable | 3sufC-3fcyA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g0i | EPOXIDE HYDROLASE (Aspergillusniger) |
PF06441(EHN) | 5 | HIS A 374ASP A 348GLY A 116ALA A 376ALA A 377 | VPR A 1 ( 4.6A)VPR A 1 ( 4.5A)NoneNoneNone | 1.20A | 3sufC-3g0iA:undetectable | 3sufC-3g0iA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcw | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 5 | GLN A 382HIS A 226ASP A 186GLY A 384SER A 386 | None | 0.95A | 3sufC-3gcwA:undetectable | 3sufC-3gcwA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hea | ARYLESTERASE (Pseudomonasfluorescens) |
PF00561(Abhydrolase_1) | 5 | HIS A 251ASP A 222GLY A 27SER A 94ALA A 254 | EEE A 300 (-4.3A)NoneEEE A 300 (-3.4A)EEE A 300 (-1.4A)None | 1.07A | 3sufC-3heaA:undetectable | 3sufC-3heaA:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mfd | D-ALANYL-D-ALANINECARBOXYPEPTIDASEDACB (Bacillussubtilis) |
PF00768(Peptidase_S11)PF07943(PBP5_C) | 5 | HIS A 156GLY A 157ASP A 160GLY A 116ALA A 86 | None | 1.11A | 3sufC-3mfdA:undetectable | 3sufC-3mfdA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o8q | SHIKIMATE5-DEHYDROGENASE IALPHA (Vibrio cholerae) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | TYR B 73GLY B 102GLY B 61PHE B 11ALA B 51 | None | 1.10A | 3sufC-3o8qB:undetectable | 3sufC-3o8qB:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 5 | PHE A 695ASP A 733GLY A 696SER A 698ALA A 712 | NoneNoneNoneNoneSEP A 710 ( 4.2A) | 0.88A | 3sufC-3ppzA:undetectable | 3sufC-3ppzA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfh | EPIDERMIN LEADERPEPTIDE PROCESSINGSERINE PROTEASE EPIP (Staphylococcusaureus) |
PF00082(Peptidase_S8) | 5 | GLN A 389HIS A 187ASP A 140GLY A 391SER A 393 | None | 0.92A | 3sufC-3qfhA:undetectable | 3sufC-3qfhA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qo6 | PROTEASE DO-LIKE 1,CHLOROPLASTIC (Arabidopsisthaliana) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 6 | TYR A 172HIS A 173ASP A 203GLY A 280SER A 282ALA A 299 | None | 0.76A | 3sufC-3qo6A:9.8 | 3sufC-3qo6A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s29 | SUCROSE SYNTHASE 1 (Arabidopsisthaliana) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 5 | HIS A 287GLY A 288ASP A 417GLY A 302ALA A 439 | FRU A 902 (-4.0A)NoneNoneFRU A 902 ( 2.2A)FRU A 902 ( 3.7A) | 0.90A | 3sufC-3s29A:undetectable | 3sufC-3s29A:12.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6l | HEP_HAG FAMILY (Burkholderiapseudomallei) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 36GLY A 64SER A 53ALA A 55ALA A 69 | None | 1.12A | 3sufC-3s6lA:undetectable | 3sufC-3s6lA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6l | HEP_HAG FAMILY (Burkholderiapseudomallei) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 43GLY A 71SER A 60ALA A 62ALA A 76 | None | 1.17A | 3sufC-3s6lA:undetectable | 3sufC-3s6lA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6l | HEP_HAG FAMILY (Burkholderiapseudomallei) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 50GLY A 78SER A 67ALA A 69ALA A 83 | None | 1.10A | 3sufC-3s6lA:undetectable | 3sufC-3s6lA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6l | HEP_HAG FAMILY (Burkholderiapseudomallei) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 57GLY A 85SER A 74ALA A 76ALA A 90 | CL A 189 ( 4.0A)NoneNoneNoneNone | 1.13A | 3sufC-3s6lA:undetectable | 3sufC-3s6lA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6l | HEP_HAG FAMILY (Burkholderiapseudomallei) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 92GLY A 120SER A 109ALA A 111ALA A 125 | None | 1.07A | 3sufC-3s6lA:undetectable | 3sufC-3s6lA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3stj | PROTEASE DEGQ (Escherichiacoli) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | HIS A 82ASP A 112GLY A 185SER A 187ALA A 204 | None | 0.69A | 3sufC-3stjA:9.2 | 3sufC-3stjA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ufa | SERINE PROTEASE SPLA (Staphylococcusaureus) |
PF00089(Trypsin) | 5 | HIS A 39ASP A 78GLY A 152SER A 154ALA A 171 | VPF A 201 (-3.8A)NoneVPF A 201 (-3.3A)VPF A 201 (-1.7A)VPF A 201 (-4.9A) | 0.88A | 3sufC-3ufaA:11.1 | 3sufC-3ufaA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uoe | DEHYDROGENASE (Sinorhizobiummeliloti) |
PF02615(Ldh_2) | 6 | TYR A 227HIS A 145GLY A 149GLY A 204ALA A 199ALA A 213 | None | 1.42A | 3sufC-3uoeA:undetectable | 3sufC-3uoeA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vth | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) |
PF00708(Acylphosphatase)PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 6 | TYR A 511GLY A 510ASP A 460GLY A 701ALA A 486ALA A 489 | NoneAP2 A 806 ( 4.8A)NoneAP2 A 806 ( 4.3A)NoneNone | 1.41A | 3sufC-3vthA:undetectable | 3sufC-3vthA:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wj2 | CARBOXYLESTERASE (Ferroplasmaacidiphilum) |
PF07859(Abhydrolase_3) | 5 | HIS A 281ASP A 251GLY A 84SER A 156ALA A 284 | None | 1.16A | 3sufC-3wj2A:undetectable | 3sufC-3wj2A:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wmr | PROLINEIMINOPEPTIDASE (Streptomyceshalstedii) |
PF00561(Abhydrolase_1) | 5 | HIS A 277ASP A 250GLY A 38SER A 110ALA A 133 | None | 1.18A | 3sufC-3wmrA:undetectable | 3sufC-3wmrA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zz1 | BETA-D-GLUCOSIDEGLUCOHYDROLASE (Trichodermareesei) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | GLY A 574GLY A 698PHE A 669ALA A 655ALA A 667 | None | 1.14A | 3sufC-3zz1A:undetectable | 3sufC-3zz1A:15.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 5 | GLY A 241GLY A 150SER A 153PHE A 296ALA A 300 | None | 1.13A | 3sufC-4a01A:undetectable | 3sufC-4a01A:14.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aj9 | CATALASE-3 (Neurosporacrassa) |
PF00199(Catalase)PF06628(Catalase-rel) | 5 | PHE A 707GLY A 701PHE A 559ALA A 274ALA A 275 | NoneNoneNoneNoneACT A1717 ( 4.5A) | 1.14A | 3sufC-4aj9A:undetectable | 3sufC-4aj9A:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bxs | VENOM PROTHROMBINACTIVATORPSEUTARIN-CNON-CATALYTICSUBUNIT (Pseudonajatextilis) |
PF00754(F5_F8_type_C)PF07732(Cu-oxidase_3) | 5 | GLY V 118SER V 120PHE V 75ALA V 9ALA V 10 | None | 1.13A | 3sufC-4bxsV:undetectable | 3sufC-4bxsV:10.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fcs | VERSATILE PEROXIDASEVPL2 (Pleurotuseryngii) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 5 | GLY A 51GLY A 63SER A 64PHE A 68ALA A 131 | CA A 402 ( 4.7A)None CA A 402 (-2.4A)NoneNone | 0.97A | 3sufC-4fcsA:undetectable | 3sufC-4fcsA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fsf | PENICILLIN-BINDINGPROTEIN 3 (Pseudomonasaeruginosa) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | TYR A 532SER A 485PHE A 507ALA A 539ALA A 474 | None0W0 A 601 (-2.9A)NoneNoneNone | 1.07A | 3sufC-4fsfA:undetectable | 3sufC-4fsfA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hu0 | CELLULASE (unculturedbacterium) |
PF00150(Cellulase) | 5 | GLN A 157PHE A 197GLY A 149ALA A 237ALA A 232 | CTT A 401 (-3.1A)CTT A 401 (-4.8A)NoneNoneNone | 1.19A | 3sufC-4hu0A:undetectable | 3sufC-4hu0A:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvl | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumthermoresistibile) |
PF00082(Peptidase_S8) | 5 | HIS A 123ASP A 92GLY A 332SER A 334ALA A 204 | ZN A 506 ( 3.3A)NoneACT A 512 (-3.5A) ZN A 506 ( 2.2A)ACT A 512 ( 4.7A) | 1.07A | 3sufC-4hvlA:undetectable | 3sufC-4hvlA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iig | BETA-GLUCOSIDASE 1 (Aspergillusaculeatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | GLY A 38GLY A 272SER A 752ALA A 239ALA A 236 | None | 1.09A | 3sufC-4iigA:undetectable | 3sufC-4iigA:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inl | SERINE PROTEASE SPLD (Staphylococcusaureus) |
PF13365(Trypsin_2) | 5 | HIS A 39ASP A 78GLY A 154SER A 156ALA A 173 | None | 0.78A | 3sufC-4inlA:11.7 | 3sufC-4inlA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4izo | PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXYLASE, ATPASESUBUNIT (Burkholderiathailandensis) |
PF02222(ATP-grasp) | 5 | HIS A 58GLY A 52GLY A 21ALA A 61ALA A 62 | None | 1.16A | 3sufC-4izoA:undetectable | 3sufC-4izoA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpg | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | HIS A 123ASP A 92GLY A 332SER A 334ALA A 204 | None | 1.08A | 3sufC-4kpgA:undetectable | 3sufC-4kpgA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m1z | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | HIS A 123ASP A 92GLY A 332SER A 334ALA A 204 | None | 0.98A | 3sufC-4m1zA:undetectable | 3sufC-4m1zA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mzd | NISIN LEADERPEPTIDE-PROCESSINGSERINE PROTEASE NISP (Lactococcuslactis) |
PF00082(Peptidase_S8) | 5 | HIS A 306ASP A 259GLY A 510SER A 512ALA A 364 | None | 0.85A | 3sufC-4mzdA:undetectable | 3sufC-4mzdA:17.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nwk | HCV NS3 1A PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 11 | GLN A 41PHE A 43TYR A 56HIS A 57GLY A 58ASP A 81GLY A 137SER A 139PHE A 154ALA A 156ALA A 157 | 2R8 A 301 ( 3.5A)2R8 A 301 (-4.6A)None2R8 A 301 (-3.3A)2R8 A 301 (-3.5A)2R8 A 301 (-3.6A)GOL A 305 ( 3.2A)2R8 A 301 (-2.6A)2R8 A 301 (-3.7A)2R8 A 301 (-3.1A)2R8 A 301 (-3.8A) | 0.51A | 3sufC-4nwkA:35.2 | 3sufC-4nwkA:99.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ov6 | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 5 | GLN B 382HIS B 226ASP B 186GLY B 384SER B 386 | None | 0.94A | 3sufC-4ov6B:undetectable | 3sufC-4ov6B:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pj2 | PUTATIVE EXPORTEDPROTEIN (Aeromonashydrophila) |
PF16743(PliI) | 5 | HIS A 126ASP A 111GLY A 129SER A 109ALA A 139 | None | 1.19A | 3sufC-4pj2A:undetectable | 3sufC-4pj2A:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rbn | SUCROSESYNTHASE:GLYCOSYLTRANSFERASES GROUP 1 (Nitrosomonaseuropaea) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 5 | HIS A 273GLY A 274ASP A 404GLY A 288ALA A 426 | None | 0.97A | 3sufC-4rbnA:undetectable | 3sufC-4rbnA:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s2t | PROTEIN APP-1 (Caenorhabditiselegans) |
PF00557(Peptidase_M24)PF01321(Creatinase_N)PF16188(Peptidase_M24_C)PF16189(Creatinase_N_2) | 5 | GLN P 82PHE P 57TYR P 43GLY P 59GLY P 56 | SO4 P 705 (-3.9A)NoneNoneNoneNone | 1.18A | 3sufC-4s2tP:undetectable | 3sufC-4s2tP:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x2x | NS6 PROTEASE (Norwalk virus) |
PF05416(Peptidase_C37) | 5 | HIS A 30ASP A 54GLY A 137ALA A 159ALA A 160 | None | 0.60A | 3sufC-4x2xA:10.3 | 3sufC-4x2xA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9n | L-ALPHA-GLYCEROPHOSPHATE OXIDASE (Mycoplasmapneumoniae) |
PF01266(DAO) | 5 | PHE A 329GLY A 350GLY A 345ALA A 208ALA A 209 | NoneFAD A 401 (-3.2A)NoneNoneFAD A 401 (-3.6A) | 1.13A | 3sufC-4x9nA:undetectable | 3sufC-4x9nA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xeq | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Desulfovibriovulgaris) |
PF03480(DctP) | 5 | GLN A 92GLY A 148GLY A 94ALA A 99ALA A 43 | None | 1.13A | 3sufC-4xeqA:undetectable | 3sufC-4xeqA:23.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyk | RIBOSOME BIOGENESISPROTEIN YTM1 (Chaetomiumthermophilum) |
PF00400(WD40)PF08154(NLE) | 5 | HIS A 224GLY A 223ASP A 246ALA A 243ALA A 303 | None | 1.06A | 3sufC-5cykA:undetectable | 3sufC-5cykA:17.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e59 | FRNE PROTEIN (Deinococcusradiodurans) |
PF01323(DSBA) | 5 | PHE A 193TYR A 200GLY A 201GLY A 204ALA A 207 | None | 1.18A | 3sufC-5e59A:undetectable | 3sufC-5e59A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eqi | SOLUTE CARRIERFAMILY 2,FACILITATED GLUCOSETRANSPORTER MEMBER 1 (Homo sapiens) |
PF00083(Sugar_tr) | 5 | TYR A 293GLY A 314SER A 313PHE A 373ALA A 309 | None | 1.12A | 3sufC-5eqiA:undetectable | 3sufC-5eqiA:17.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eqq | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 10 | GLN A1041PHE A1043TYR A1056HIS A1057GLY A1058ASP A1081GLY A1137PHE A1154ALA A1156ALA A1157 | 5RS A1203 (-2.9A)5RS A1203 (-4.3A)SO4 A1201 ( 4.5A)5RS A1203 (-2.5A)5RS A1203 ( 2.9A)5RS A1203 (-3.5A)5RS A1203 (-3.2A)5RS A1203 (-3.3A)5RS A1203 (-2.9A)5RS A1203 (-3.5A) | 0.32A | 3sufC-5eqqA:33.9 | 3sufC-5eqqA:94.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kp7 | CURD (Mooreaproducens) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 5 | GLY A 117GLY A 327SER A 325PHE A 324ALA A 227 | None | 1.03A | 3sufC-5kp7A:undetectable | 3sufC-5kp7A:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mif | 'CARBOXYL ESTERASE 2 (Tubermelanosporum) |
PF07859(Abhydrolase_3) | 5 | HIS A 317ASP A 287GLY A 117SER A 190ALA A 320 | None | 1.12A | 3sufC-5mifA:undetectable | 3sufC-5mifA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5to3 | PROTHROMBIN,THROMBOMODULIN (Homo sapiens) |
PF00089(Trypsin)PF09064(Tme5_EGF_like) | 5 | HIS B 58ASP B 114GLY B 218SER B 220ALA B 242 | 0G6 B 501 (-2.5A)None0G6 B 501 (-3.9A)0G6 B 501 (-1.3A)0G6 B 501 (-3.4A) | 0.82A | 3sufC-5to3B:2.3 | 3sufC-5to3B:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr7 | D-ALANYL-D-ALANINECARBOXYPEPTIDASE (Vibrio cholerae) |
PF00768(Peptidase_S11)PF07943(PBP5_C) | 5 | HIS A 48ASP A 46GLY A 250PHE A 279ALA A 247 | None | 1.15A | 3sufC-5tr7A:undetectable | 3sufC-5tr7A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u24 | PUTATIVEAMINOTRANSFERASE (Campylobacterjejuni) |
PF01041(DegT_DnrJ_EryC1) | 5 | TYR A 132GLY A 133GLY A 161PHE A 178ALA A 176 | None | 1.15A | 3sufC-5u24A:undetectable | 3sufC-5u24A:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vlh | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8)PF05922(Inhibitor_I9) | 5 | GLN A 382HIS A 226ASP A 186GLY A 384SER A 386 | None | 0.89A | 3sufC-5vlhA:undetectable | 3sufC-5vlhA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vlh | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8)PF05922(Inhibitor_I9) | 5 | HIS A 226ASP A 186GLY A 384SER A 386ALA A 290 | None | 0.97A | 3sufC-5vlhA:undetectable | 3sufC-5vlhA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdx | JFH-1 NS3 (Hepacivirus C) |
no annotation | 10 | GLN A 41PHE A 43TYR A 56HIS A 57GLY A 58GLY A 137SER A 139PHE A 154ALA A 156ALA A 157 | None | 0.60A | 3sufC-5wdxA:26.8 | 3sufC-5wdxA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdx | JFH-1 NS3 (Hepacivirus C) |
no annotation | 10 | PHE A 43TYR A 56HIS A 57GLY A 58ASP A 81GLY A 137SER A 139PHE A 154ALA A 156ALA A 157 | None | 0.37A | 3sufC-5wdxA:26.8 | 3sufC-5wdxA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cyz | HOMOSERINE KINASE (Mycobacteroidesabscessus) |
no annotation | 5 | GLY A 101GLY A 268SER A 265ALA A 182ALA A 183 | ANP A 401 ( 4.2A)NoneNoneNoneNone | 0.86A | 3sufC-6cyzA:undetectable | 3sufC-6cyzA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en4 | SPLICING FACTOR 3BSUBUNIT 3SPLICING FACTOR 3BSUBUNIT 5 (Homo sapiens) |
no annotation | 5 | PHE A 353ASP B 48GLY A 354SER A 405ALA A 11 | None | 1.14A | 3sufC-6en4A:undetectable | 3sufC-6en4A:17.13 |