SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUF_C_SUEC1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8q BROMOPEROXIDASE A1

(Kitasatospora
aureofaciens)
PF00561
(Abhydrolase_1)
5 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
None
1.05A 3sufC-1a8qA:
undetectable
3sufC-1a8qA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)


(Desulfomicrobium
baculatum)
PF00374
(NiFeSe_Hases)
5 GLN L 111
ASP L 490
PHE L 117
ALA L 121
ALA L 122
None
1.18A 3sufC-1cc1L:
undetectable
3sufC-1cc1L:
17.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)


(Hepacivirus C)
PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD)
11 GLN A  41
PHE A  43
TYR A  56
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
None
0.68A 3sufC-1cu1A:
34.0
3sufC-1cu1A:
81.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus)
PF13365
(Trypsin_2)
5 TYR A  64
HIS A  65
ASP A 114
GLY A 184
SER A 186
None
1.10A 3sufC-1dt2A:
9.9
3sufC-1dt2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)


(Paracoccus
denitrificans)
PF00766
(ETF_alpha)
PF01012
(ETF)
5 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
1.14A 3sufC-1efpA:
undetectable
3sufC-1efpA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN


(Homo sapiens)
PF00766
(ETF_alpha)
PF01012
(ETF)
5 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
1.10A 3sufC-1efvA:
undetectable
3sufC-1efvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius)
PF07859
(Abhydrolase_3)
5 HIS A 282
ASP A 252
GLY A  82
SER A 155
ALA A 285
EPE  A 455 (-4.0A)
None
EPE  A 455 (-3.5A)
EPE  A 455 (-1.4A)
None
1.11A 3sufC-1evqA:
undetectable
3sufC-1evqA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eys PHOTOSYNTHETIC
REACTION CENTER


(Thermochromatium
tepidum)
PF00124
(Photo_RC)
5 PHE L  34
GLY L  38
SER L 107
ALA L 102
ALA L 101
None
None
None
None
BPH  L 606 ( 3.9A)
1.19A 3sufC-1eysL:
undetectable
3sufC-1eysL:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 TYR A 281
GLY A 217
GLY A 151
ALA A 242
ALA A 243
None
None
None
None
MG  A1432 ( 4.8A)
1.12A 3sufC-1iyxA:
undetectable
3sufC-1iyxA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE


(Saccharomyces
cerevisiae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 GLN A 501
GLY A 520
ASP A 176
ALA A 531
ALA A 532
None
FAD  A 701 ( 4.4A)
None
None
None
1.11A 3sufC-1jscA:
undetectable
3sufC-1jscA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1j HEAT SHOCK PROTEASE
HTRA


(Thermotoga
maritima)
PF13365
(Trypsin_2)
5 TYR A  96
HIS A  97
ASP A 127
GLY A 204
SER A 206
None
0.94A 3sufC-1l1jA:
8.0
3sufC-1l1jA:
23.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
10 GLN A  41
PHE A  43
TYR A  56
HIS A  57
GLY A  58
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
None
0.66A 3sufC-1ns3A:
29.8
3sufC-1ns3A:
78.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
6 GLN A  41
TYR A  56
HIS A  57
ASP A  81
GLY A 137
SER A 139
None
0.93A 3sufC-1ns3A:
29.8
3sufC-1ns3A:
78.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE


(Bacillus
intermedius)
PF00089
(Trypsin)
5 HIS A  47
ASP A  97
GLY A 169
SER A 171
ALA A 188
None
0.81A 3sufC-1p3cA:
10.1
3sufC-1p3cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4t OUTER MEMBRANE
PROTEIN NSPA


(Neisseria
meningitidis)
PF02462
(Opacity)
5 TYR A 132
GLY A 107
GLY A  65
ALA A  84
ALA A  68
CXE  A 300 ( 4.8A)
None
None
CXE  A 400 ( 4.9A)
CXE  A 400 ( 3.8A)
1.14A 3sufC-1p4tA:
undetectable
3sufC-1p4tA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica)
PF05658
(YadA_head)
PF05662
(YadA_stalk)
5 GLY A  76
GLY A 104
SER A  93
ALA A  95
ALA A 109
None
1.05A 3sufC-1p9hA:
undetectable
3sufC-1p9hA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica)
PF05658
(YadA_head)
PF05662
(YadA_stalk)
5 GLY A  90
GLY A 118
SER A 107
ALA A 109
ALA A 123
None
1.06A 3sufC-1p9hA:
undetectable
3sufC-1p9hA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT


(Wolinella
succinogenes)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 TYR A 423
GLY A 421
GLY A  17
ALA A 395
ALA A 394
None
1.18A 3sufC-1qlbA:
undetectable
3sufC-1qlbA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei)
PF16499
(Melibiase_2)
5 GLY A  66
ASP A 117
GLY A  62
ALA A 109
ALA A 102
None
1.05A 3sufC-1sznA:
undetectable
3sufC-1sznA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE


(Thermotoga
maritima)
PF00465
(Fe-ADH)
5 TYR A 162
GLY A 163
GLY A 149
ALA A 107
ALA A 109
None
1.16A 3sufC-1vljA:
undetectable
3sufC-1vljA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983


(Mycobacterium
tuberculosis)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 HIS A  49
ASP A  88
GLY A 167
SER A 169
ALA A 186
None
0.85A 3sufC-1y8tA:
12.4
3sufC-1y8tA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))


(Streptococcus
pyogenes)
PF00390
(malic)
PF03949
(Malic_M)
5 PHE A 286
GLY A 309
GLY A 264
ALA A 289
ALA A 267
None
1.08A 3sufC-2a9fA:
undetectable
3sufC-2a9fA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bej SEGREGATION PROTEIN

(Thermus
thermophilus)
PF13614
(AAA_31)
5 TYR A 112
ASP A 109
GLY A 136
ALA A 133
ALA A 132
None
1.17A 3sufC-2bejA:
undetectable
3sufC-2bejA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon)
PF07859
(Abhydrolase_3)
5 TYR A  79
GLY A 157
GLY A 257
ALA A 243
ALA A 271
None
1.15A 3sufC-2c7bA:
undetectable
3sufC-2c7bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens)
PF00026
(Asp)
5 TYR A 318
GLY A 335
GLY A  27
SER A  26
ALA A 173
None
1.13A 3sufC-2ewyA:
undetectable
3sufC-2ewyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana)
PF00291
(PALP)
5 GLY A 225
GLY A 267
PHE A 295
ALA A 273
ALA A 274
PLP  A 400 (-3.5A)
None
None
None
None
1.00A 3sufC-2isqA:
undetectable
3sufC-2isqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4r EXOPOLYPHOSPHATASE

(Aquifex
aeolicus)
PF02541
(Ppx-GppA)
5 HIS A 232
GLY A 233
GLY A 208
ALA A 126
ALA A 123
None
1.10A 3sufC-2j4rA:
undetectable
3sufC-2j4rA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jl4 MALEYLPYRUVATE
ISOMERASE


(Ralstonia sp.
U2)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
5 TYR A 154
GLY A 157
ASP A 164
GLY A  88
ALA A  94
None
1.17A 3sufC-2jl4A:
undetectable
3sufC-2jl4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o69 IRON-UTILIZATION
PERIPLASMIC PROTEIN


(Haemophilus
influenzae)
PF01547
(SBP_bac_1)
5 TYR A 265
GLY A 100
GLY A 229
ALA A  12
ALA A  13
None
1.15A 3sufC-2o69A:
undetectable
3sufC-2o69A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE


(Francisella
tularensis)
no annotation 5 HIS B 110
GLY B 109
ASP B 131
GLY B   9
ALA B 138
None
0.98A 3sufC-2qjtB:
undetectable
3sufC-2qjtB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus)
PF00089
(Trypsin)
5 HIS A  39
ASP A  77
GLY A 155
SER A 157
ALA A 174
None
0.82A 3sufC-2vidA:
5.7
3sufC-2vidA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 174
GLY A 403
SER A 401
ALA A 410
ALA A 290
None
TLM  A1424 (-3.9A)
None
None
None
1.13A 3sufC-2wgeA:
undetectable
3sufC-2wgeA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqh IMMUNOGLOBULIN-BINDI
NG PROTEIN EIBD


(Escherichia
coli)
PF05658
(YadA_head)
5 GLY A 166
GLY A 194
SER A 183
ALA A 185
ALA A 199
None
1.09A 3sufC-2xqhA:
undetectable
3sufC-2xqhA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr1 CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
100 KD SUBUNIT


(Methanosarcina
mazei)
PF07521
(RMMBL)
PF07650
(KH_2)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7)
5 TYR A 353
HIS A 580
ASP A 352
GLY A 535
PHE A 416
None
None
ZN  A1639 ( 2.3A)
None
None
1.13A 3sufC-2xr1A:
undetectable
3sufC-2xr1A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis)
PF07859
(Abhydrolase_3)
5 TYR A  82
GLY A 160
GLY A 260
ALA A 246
ALA A 274
None
1.17A 3sufC-2yh2A:
undetectable
3sufC-2yh2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1k (NEO)PULLULANASE

(Thermus
thermophilus)
PF00128
(Alpha-amylase)
5 GLN A 284
PHE A 261
GLY A 407
GLY A 260
ALA A 266
None
1.16A 3sufC-2z1kA:
undetectable
3sufC-2z1kA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274)
PF00067
(p450)
5 GLN A 354
PHE A 357
GLY A 358
ALA A 303
ALA A 327
None
HEM  A 500 (-4.5A)
HEM  A 500 (-3.7A)
None
None
1.20A 3sufC-2z3tA:
undetectable
3sufC-2z3tA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE


(Thermotoga
maritima)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
5 PHE A  38
GLY A  40
GLY A  37
SER A  32
ALA A  30
None
0.92A 3sufC-2zsgA:
undetectable
3sufC-2zsgA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE


(Bifidobacterium
breve)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
5 GLY A 158
GLY A 484
SER A 162
ALA A 164
ALA A 167
None
1.17A 3sufC-3ahiA:
undetectable
3sufC-3ahiA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE


(Bifidobacterium
longum)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
5 GLY A 158
GLY A 484
SER A 162
ALA A 164
ALA A 167
None
1.19A 3sufC-3ai7A:
undetectable
3sufC-3ai7A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP


(Escherichia
coli)
PF02395
(Peptidase_S6)
5 HIS A 125
ASP A 153
GLY A 257
SER A 259
ALA A 281
None
0.77A 3sufC-3ak5A:
6.5
3sufC-3ak5A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dme CONSERVED EXPORTED
PROTEIN


(Bordetella
pertussis)
PF01266
(DAO)
5 PHE A 329
GLY A 352
GLY A 347
ALA A 204
ALA A 205
None
FAD  A 500 (-3.1A)
None
None
FAD  A 500 (-3.6A)
1.17A 3sufC-3dmeA:
undetectable
3sufC-3dmeA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum)
PF05448
(AXE1)
5 PHE A 207
HIS A 301
ASP A 272
GLY A  90
SER A 182
None
1.05A 3sufC-3fcyA:
undetectable
3sufC-3fcyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger)
PF06441
(EHN)
5 HIS A 374
ASP A 348
GLY A 116
ALA A 376
ALA A 377
VPR  A   1 ( 4.6A)
VPR  A   1 ( 4.5A)
None
None
None
1.20A 3sufC-3g0iA:
undetectable
3sufC-3g0iA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
5 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
None
0.95A 3sufC-3gcwA:
undetectable
3sufC-3gcwA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens)
PF00561
(Abhydrolase_1)
5 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
1.07A 3sufC-3heaA:
undetectable
3sufC-3heaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB


(Bacillus
subtilis)
PF00768
(Peptidase_S11)
PF07943
(PBP5_C)
5 HIS A 156
GLY A 157
ASP A 160
GLY A 116
ALA A  86
None
1.11A 3sufC-3mfdA:
undetectable
3sufC-3mfdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8q SHIKIMATE
5-DEHYDROGENASE I
ALPHA


(Vibrio cholerae)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 TYR B  73
GLY B 102
GLY B  61
PHE B  11
ALA B  51
None
1.10A 3sufC-3o8qB:
undetectable
3sufC-3o8qB:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
5 PHE A 695
ASP A 733
GLY A 696
SER A 698
ALA A 712
None
None
None
None
SEP  A 710 ( 4.2A)
0.88A 3sufC-3ppzA:
undetectable
3sufC-3ppzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP


(Staphylococcus
aureus)
PF00082
(Peptidase_S8)
5 GLN A 389
HIS A 187
ASP A 140
GLY A 391
SER A 393
None
0.92A 3sufC-3qfhA:
undetectable
3sufC-3qfhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
6 TYR A 172
HIS A 173
ASP A 203
GLY A 280
SER A 282
ALA A 299
None
0.76A 3sufC-3qo6A:
9.8
3sufC-3qo6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
0.90A 3sufC-3s29A:
undetectable
3sufC-3s29A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei)
PF05658
(YadA_head)
PF05662
(YadA_stalk)
5 GLY A  36
GLY A  64
SER A  53
ALA A  55
ALA A  69
None
1.12A 3sufC-3s6lA:
undetectable
3sufC-3s6lA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei)
PF05658
(YadA_head)
PF05662
(YadA_stalk)
5 GLY A  43
GLY A  71
SER A  60
ALA A  62
ALA A  76
None
1.17A 3sufC-3s6lA:
undetectable
3sufC-3s6lA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei)
PF05658
(YadA_head)
PF05662
(YadA_stalk)
5 GLY A  50
GLY A  78
SER A  67
ALA A  69
ALA A  83
None
1.10A 3sufC-3s6lA:
undetectable
3sufC-3s6lA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei)
PF05658
(YadA_head)
PF05662
(YadA_stalk)
5 GLY A  57
GLY A  85
SER A  74
ALA A  76
ALA A  90
CL  A 189 ( 4.0A)
None
None
None
None
1.13A 3sufC-3s6lA:
undetectable
3sufC-3s6lA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei)
PF05658
(YadA_head)
PF05662
(YadA_stalk)
5 GLY A  92
GLY A 120
SER A 109
ALA A 111
ALA A 125
None
1.07A 3sufC-3s6lA:
undetectable
3sufC-3s6lA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
None
0.69A 3sufC-3stjA:
9.2
3sufC-3stjA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufa SERINE PROTEASE SPLA

(Staphylococcus
aureus)
PF00089
(Trypsin)
5 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
0.88A 3sufC-3ufaA:
11.1
3sufC-3ufaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti)
PF02615
(Ldh_2)
6 TYR A 227
HIS A 145
GLY A 149
GLY A 204
ALA A 199
ALA A 213
None
1.42A 3sufC-3uoeA:
undetectable
3sufC-3uoeA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR


(Caldanaerobacter
subterraneus)
PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF)
6 TYR A 511
GLY A 510
ASP A 460
GLY A 701
ALA A 486
ALA A 489
None
AP2  A 806 ( 4.8A)
None
AP2  A 806 ( 4.3A)
None
None
1.41A 3sufC-3vthA:
undetectable
3sufC-3vthA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum)
PF07859
(Abhydrolase_3)
5 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
None
1.16A 3sufC-3wj2A:
undetectable
3sufC-3wj2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmr PROLINE
IMINOPEPTIDASE


(Streptomyces
halstedii)
PF00561
(Abhydrolase_1)
5 HIS A 277
ASP A 250
GLY A  38
SER A 110
ALA A 133
None
1.18A 3sufC-3wmrA:
undetectable
3sufC-3wmrA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE


(Trichoderma
reesei)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 GLY A 574
GLY A 698
PHE A 669
ALA A 655
ALA A 667
None
1.14A 3sufC-3zz1A:
undetectable
3sufC-3zz1A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE


(Vigna radiata)
PF03030
(H_PPase)
5 GLY A 241
GLY A 150
SER A 153
PHE A 296
ALA A 300
None
1.13A 3sufC-4a01A:
undetectable
3sufC-4a01A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 PHE A 707
GLY A 701
PHE A 559
ALA A 274
ALA A 275
None
None
None
None
ACT  A1717 ( 4.5A)
1.14A 3sufC-4aj9A:
undetectable
3sufC-4aj9A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT


(Pseudonaja
textilis)
PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3)
5 GLY V 118
SER V 120
PHE V  75
ALA V   9
ALA V  10
None
1.13A 3sufC-4bxsV:
undetectable
3sufC-4bxsV:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcs VERSATILE PEROXIDASE
VPL2


(Pleurotus
eryngii)
PF00141
(peroxidase)
PF11895
(Peroxidase_ext)
5 GLY A  51
GLY A  63
SER A  64
PHE A  68
ALA A 131
CA  A 402 ( 4.7A)
None
CA  A 402 (-2.4A)
None
None
0.97A 3sufC-4fcsA:
undetectable
3sufC-4fcsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsf PENICILLIN-BINDING
PROTEIN 3


(Pseudomonas
aeruginosa)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 TYR A 532
SER A 485
PHE A 507
ALA A 539
ALA A 474
None
0W0  A 601 (-2.9A)
None
None
None
1.07A 3sufC-4fsfA:
undetectable
3sufC-4fsfA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu0 CELLULASE

(uncultured
bacterium)
PF00150
(Cellulase)
5 GLN A 157
PHE A 197
GLY A 149
ALA A 237
ALA A 232
CTT  A 401 (-3.1A)
CTT  A 401 (-4.8A)
None
None
None
1.19A 3sufC-4hu0A:
undetectable
3sufC-4hu0A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvl MEMBRANE-ANCHORED
MYCOSIN MYCP1


(Mycolicibacterium
thermoresistibile)
PF00082
(Peptidase_S8)
5 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
ZN  A 506 ( 3.3A)
None
ACT  A 512 (-3.5A)
ZN  A 506 ( 2.2A)
ACT  A 512 ( 4.7A)
1.07A 3sufC-4hvlA:
undetectable
3sufC-4hvlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 GLY A  38
GLY A 272
SER A 752
ALA A 239
ALA A 236
None
1.09A 3sufC-4iigA:
undetectable
3sufC-4iigA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inl SERINE PROTEASE SPLD

(Staphylococcus
aureus)
PF13365
(Trypsin_2)
5 HIS A  39
ASP A  78
GLY A 154
SER A 156
ALA A 173
None
0.78A 3sufC-4inlA:
11.7
3sufC-4inlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT


(Burkholderia
thailandensis)
PF02222
(ATP-grasp)
5 HIS A  58
GLY A  52
GLY A  21
ALA A  61
ALA A  62
None
1.16A 3sufC-4izoA:
undetectable
3sufC-4izoA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
5 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
None
1.08A 3sufC-4kpgA:
undetectable
3sufC-4kpgA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
5 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
None
0.98A 3sufC-4m1zA:
undetectable
3sufC-4m1zA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP


(Lactococcus
lactis)
PF00082
(Peptidase_S8)
5 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
None
0.85A 3sufC-4mzdA:
undetectable
3sufC-4mzdA:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
11 GLN A  41
PHE A  43
TYR A  56
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
2R8  A 301 ( 3.5A)
2R8  A 301 (-4.6A)
None
2R8  A 301 (-3.3A)
2R8  A 301 (-3.5A)
2R8  A 301 (-3.6A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-2.6A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
0.51A 3sufC-4nwkA:
35.2
3sufC-4nwkA:
99.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
5 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
None
0.94A 3sufC-4ov6B:
undetectable
3sufC-4ov6B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj2 PUTATIVE EXPORTED
PROTEIN


(Aeromonas
hydrophila)
PF16743
(PliI)
5 HIS A 126
ASP A 111
GLY A 129
SER A 109
ALA A 139
None
1.19A 3sufC-4pj2A:
undetectable
3sufC-4pj2A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1


(Nitrosomonas
europaea)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 HIS A 273
GLY A 274
ASP A 404
GLY A 288
ALA A 426
None
0.97A 3sufC-4rbnA:
undetectable
3sufC-4rbnA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2)
5 GLN P  82
PHE P  57
TYR P  43
GLY P  59
GLY P  56
SO4  P 705 (-3.9A)
None
None
None
None
1.18A 3sufC-4s2tP:
undetectable
3sufC-4s2tP:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus)
PF05416
(Peptidase_C37)
5 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
None
0.60A 3sufC-4x2xA:
10.3
3sufC-4x2xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE


(Mycoplasma
pneumoniae)
PF01266
(DAO)
5 PHE A 329
GLY A 350
GLY A 345
ALA A 208
ALA A 209
None
FAD  A 401 (-3.2A)
None
None
FAD  A 401 (-3.6A)
1.13A 3sufC-4x9nA:
undetectable
3sufC-4x9nA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT


(Desulfovibrio
vulgaris)
PF03480
(DctP)
5 GLN A  92
GLY A 148
GLY A  94
ALA A  99
ALA A  43
None
1.13A 3sufC-4xeqA:
undetectable
3sufC-4xeqA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1


(Chaetomium
thermophilum)
PF00400
(WD40)
PF08154
(NLE)
5 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
1.06A 3sufC-5cykA:
undetectable
3sufC-5cykA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e59 FRNE PROTEIN

(Deinococcus
radiodurans)
PF01323
(DSBA)
5 PHE A 193
TYR A 200
GLY A 201
GLY A 204
ALA A 207
None
1.18A 3sufC-5e59A:
undetectable
3sufC-5e59A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1


(Homo sapiens)
PF00083
(Sugar_tr)
5 TYR A 293
GLY A 314
SER A 313
PHE A 373
ALA A 309
None
1.12A 3sufC-5eqiA:
undetectable
3sufC-5eqiA:
17.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
10 GLN A1041
PHE A1043
TYR A1056
HIS A1057
GLY A1058
ASP A1081
GLY A1137
PHE A1154
ALA A1156
ALA A1157
5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
0.32A 3sufC-5eqqA:
33.9
3sufC-5eqqA:
94.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
5 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
None
1.03A 3sufC-5kp7A:
undetectable
3sufC-5kp7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum)
PF07859
(Abhydrolase_3)
5 HIS A 317
ASP A 287
GLY A 117
SER A 190
ALA A 320
None
1.12A 3sufC-5mifA:
undetectable
3sufC-5mifA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN


(Homo sapiens)
PF00089
(Trypsin)
PF09064
(Tme5_EGF_like)
5 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
0.82A 3sufC-5to3B:
2.3
3sufC-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE


(Vibrio cholerae)
PF00768
(Peptidase_S11)
PF07943
(PBP5_C)
5 HIS A  48
ASP A  46
GLY A 250
PHE A 279
ALA A 247
None
1.15A 3sufC-5tr7A:
undetectable
3sufC-5tr7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE


(Campylobacter
jejuni)
PF01041
(DegT_DnrJ_EryC1)
5 TYR A 132
GLY A 133
GLY A 161
PHE A 178
ALA A 176
None
1.15A 3sufC-5u24A:
undetectable
3sufC-5u24A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9)
5 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
None
0.89A 3sufC-5vlhA:
undetectable
3sufC-5vlhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9)
5 HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
None
0.97A 3sufC-5vlhA:
undetectable
3sufC-5vlhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C)
no annotation 10 GLN A  41
PHE A  43
TYR A  56
HIS A  57
GLY A  58
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
None
0.60A 3sufC-5wdxA:
26.8
3sufC-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C)
no annotation 10 PHE A  43
TYR A  56
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
None
0.37A 3sufC-5wdxA:
26.8
3sufC-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cyz HOMOSERINE KINASE

(Mycobacteroides
abscessus)
no annotation 5 GLY A 101
GLY A 268
SER A 265
ALA A 182
ALA A 183
ANP  A 401 ( 4.2A)
None
None
None
None
0.86A 3sufC-6cyzA:
undetectable
3sufC-6cyzA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5


(Homo sapiens)
no annotation 5 PHE A 353
ASP B  48
GLY A 354
SER A 405
ALA A  11
None
1.14A 3sufC-6en4A:
undetectable
3sufC-6en4A:
17.13