SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUF_B_SUEB1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3n PROTEIN (KETOACYL
ACYL CARRIER PROTEIN
SYNTHASE 2)

(Escherichia
coli) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 TYR A 179
LEU A 238
ARG A 175
 None
 0.79A 3sufB-1b3nA:
0.0		 3sufB-1b3nA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR 2

(Homo sapiens) 		PF00167
(FGF) 		3 TYR A 111
LEU A 138
ARG A 107
 None
 0.63A 3sufB-1fq9A:
0.0		 3sufB-1fq9A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 TYR A 110
LEU A  97
ARG A 109
 None
 0.76A 3sufB-1g8xA:
0.0		 3sufB-1g8xA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 TYR A 313
LEU A 230
ARG A 311
 None
 0.72A 3sufB-1i7oA:
0.0		 3sufB-1i7oA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 TYR A 100
LEU A 339
ARG A 344
 None
FAD  A 421 (-4.6A)
None
 0.76A 3sufB-1iqrA:
undetectable		 3sufB-1iqrA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR A 211
LEU A 199
ARG A 210
 None
 0.76A 3sufB-1llaA:
0.0		 3sufB-1llaA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5z AMPA RECEPTOR
INTERACTING PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 TYR A  68
LEU A  90
ARG A  70
 None
 0.55A 3sufB-1m5zA:
0.0		 3sufB-1m5zA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		3 TYR A  50
LEU A  29
ARG A  52
 None
None
XYP  A 601 ( 4.9A)
 0.79A 3sufB-1px8A:
0.0		 3sufB-1px8A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucp APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF02758
(PYRIN) 		3 TYR A  36
LEU A  25
ARG A  38
 None
 0.50A 3sufB-1ucpA:
undetectable		 3sufB-1ucpA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjg PUTATIVE LIPASE FROM
THE G-D-S-L FAMILY

(Nostoc sp. PCC
7120) 		PF13472
(Lipase_GDSL_2) 		3 TYR A  47
LEU A 117
ARG A  71
 None
 0.69A 3sufB-1vjgA:
undetectable		 3sufB-1vjgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		3 TYR 1  72
LEU 1 493
ARG 1 101
 None
 0.80A 3sufB-1wao1:
undetectable		 3sufB-1wao1:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlo SUFE PROTEIN

(Thermus
thermophilus) 		PF02657
(SufE) 		3 TYR A 105
LEU A 114
ARG A 103
 None
 0.78A 3sufB-1wloA:
undetectable		 3sufB-1wloA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsc HYPOTHETICAL PROTEIN
ST0229

(Sulfurisphaera
tokodaii) 		PF01871
(AMMECR1) 		3 TYR A  64
LEU A  20
ARG A 203
 None
 0.73A 3sufB-1wscA:
0.0		 3sufB-1wscA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc9 MULTIDRUG RESISTANCE
PROTEIN

(Vibrio cholerae) 		PF02321
(OEP) 		3 TYR A 200
LEU A 467
ARG A 198
 None
 0.71A 3sufB-1yc9A:
undetectable		 3sufB-1yc9A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zag PROTEIN
(ZINC-ALPHA-2-GLYCOP
ROTEIN)

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A  41
LEU A  36
ARG A  40
 None
 0.73A 3sufB-1zagA:
undetectable		 3sufB-1zagA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		3 TYR A  89
LEU A  20
ARG A  86
 None
None
EDO  A1408 ( 3.7A)
 0.69A 3sufB-1zl0A:
undetectable		 3sufB-1zl0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnl MODULATOR PROTEIN
RSBR

(Bacillus
subtilis) 		PF08678
(Rsbr_N) 		3 TYR A  96
LEU A  19
ARG A  94
 None
 0.74A 3sufB-2bnlA:
undetectable		 3sufB-2bnlA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		3 TYR A 175
LEU A 165
ARG A 174
 None
 0.67A 3sufB-2d0dA:
undetectable		 3sufB-2d0dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgx KIAA0430 PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		3 TYR A 596
LEU A 574
ARG A 565
 None
 0.80A 3sufB-2dgxA:
undetectable		 3sufB-2dgxA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		3 TYR A  29
LEU A 103
ARG A 448
 None
 0.81A 3sufB-2eceA:
undetectable		 3sufB-2eceA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7h METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF01035
(DNA_binding_1) 		3 TYR A 140
LEU A 122
ARG A 119
 None
 0.72A 3sufB-2g7hA:
undetectable		 3sufB-2g7hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		3 TYR A 248
LEU A 218
ARG A 249
 None
 0.76A 3sufB-2g9bA:
undetectable		 3sufB-2g9bA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		3 TYR A 109
LEU A 163
ARG A 103
 None
 0.74A 3sufB-2grmA:
undetectable		 3sufB-2grmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib0 CONSERVED
HYPOTHETICAL ALANINE
RICH PROTEIN

(Mycobacterium
tuberculosis) 		PF14530
(DUF4439) 		3 TYR A  38
LEU A  26
ARG A  66
 None
 0.79A 3sufB-2ib0A:
undetectable		 3sufB-2ib0A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN

(Ryegrass mottle
virus) 		PF00729
(Viral_coat) 		3 TYR A 108
LEU A  89
ARG A  93
 None
 0.75A 3sufB-2izwA:
undetectable		 3sufB-2izwA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 TYR A 372
LEU A 357
ARG A 294
 None
None
COS  A1434 (-3.3A)
 0.81A 3sufB-2jifA:
undetectable		 3sufB-2jifA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR

(Burkholderia
pseudomallei) 		PF07487
(SopE_GEF) 		3 TYR A 205
LEU A 236
ARG A 207
 None
 0.79A 3sufB-2jokA:
undetectable		 3sufB-2jokA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		3 TYR A  36
LEU A  14
ARG A  38
 None
 0.81A 3sufB-2l7bA:
undetectable		 3sufB-2l7bA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la3 UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06042
(NTP_transf_6) 		3 TYR A  91
LEU A  79
ARG A  85
 None
 0.74A 3sufB-2la3A:
undetectable		 3sufB-2la3A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 TYR A 387
LEU A 185
ARG A 343
 TYR  A 387 ( 1.3A)
LEU  A 185 ( 0.6A)
ARG  A 343 ( 0.6A)
 0.78A 3sufB-2nvvA:
undetectable		 3sufB-2nvvA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6i HD DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF01966
(HD) 		3 TYR A 236
LEU A 204
ARG A 235
 None
 0.74A 3sufB-2o6iA:
undetectable		 3sufB-2o6iA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opc AVRL567-A

(Melampsora lini) 		PF11529
(AvrL567-A) 		3 TYR A 141
LEU A  68
ARG A  43
 None
 0.69A 3sufB-2opcA:
undetectable		 3sufB-2opcA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		3 TYR A 328
LEU A 402
ARG A 405
 None
None
GG9  A 501 (-3.9A)
 0.75A 3sufB-2pqdA:
undetectable		 3sufB-2pqdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD

(Lactobacillus
paracasei) 		PF04909
(Amidohydro_2) 		3 TYR A 273
LEU A 288
ARG A 269
 None
 0.73A 3sufB-2qpxA:
undetectable		 3sufB-2qpxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		3 TYR A  81
LEU A  68
ARG A  80
 None
 0.65A 3sufB-2v26A:
undetectable		 3sufB-2v26A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1q HYALURONOGLUCOSAMINI
DASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		3 TYR A 886
LEU A 826
ARG A 925
 None
 0.78A 3sufB-2w1qA:
undetectable		 3sufB-2w1qA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		3 TYR A 110
LEU A  63
ARG A 109
 None
 0.59A 3sufB-2y2wA:
undetectable		 3sufB-2y2wA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 TYR A 589
LEU A 618
ARG A 612
 None
 0.79A 3sufB-2yiaA:
undetectable		 3sufB-2yiaA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjt ATP-DEPENDENT RNA
HELICASE SRMB

(Escherichia
coli) 		PF00271
(Helicase_C) 		3 TYR D 227
LEU D 358
ARG D 228
 None
 0.76A 3sufB-2yjtD:
undetectable		 3sufB-2yjtD:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1

(Homo sapiens) 		PF01380
(SIS) 		3 TYR A 598
LEU A 552
ARG A 544
 None
 0.67A 3sufB-2zj4A:
undetectable		 3sufB-2zj4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I
PROGRAMMED CELL
DEATH PROTEIN 4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02847
(MA3) 		3 TYR B 409
LEU A 243
ARG B 407
 None
 0.76A 3sufB-2zu6B:
undetectable		 3sufB-2zu6B:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		3 TYR A 598
LEU A 590
ARG A 597
 None
 0.81A 3sufB-2zwaA:
undetectable		 3sufB-2zwaA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		3 TYR A 151
LEU A 119
ARG A 150
 None
 0.58A 3sufB-2zzrA:
undetectable		 3sufB-2zzrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE

(Bradyrhizobium
japonicum) 		PF00561
(Abhydrolase_1) 		3 TYR A  21
LEU A  51
ARG A  22
 None
 0.72A 3sufB-3a2lA:
undetectable		 3sufB-3a2lA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		3 TYR A 384
LEU A 444
ARG A 436
 None
 0.79A 3sufB-3akfA:
undetectable		 3sufB-3akfA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		3 TYR A  54
LEU A 190
ARG A  56
 None
 0.81A 3sufB-3c4nA:
undetectable		 3sufB-3c4nA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		3 TYR A 160
LEU A 235
ARG A 157
 None
 0.65A 3sufB-3d5eA:
undetectable		 3sufB-3d5eA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ega PROTEIN PELLINO
HOMOLOG 2

(Homo sapiens) 		PF04710
(Pellino) 		3 TYR A 218
LEU A 245
ARG A 209
 None
 0.80A 3sufB-3egaA:
undetectable		 3sufB-3egaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3

(Homo sapiens) 		PF00782
(DSPc) 		3 TYR A  38
LEU A 151
ARG A 158
 None
 0.80A 3sufB-3f81A:
undetectable		 3sufB-3f81A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TYR A 220
LEU A 368
ARG A 365
 None
 0.80A 3sufB-3gyrA:
undetectable		 3sufB-3gyrA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		3 TYR A 107
LEU A  94
ARG A 106
 None
 0.77A 3sufB-3i5gA:
undetectable		 3sufB-3i5gA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ign DIGUANYLATE CYCLASE

(Marinobacter
hydrocarbonoclasticus) 		PF00990
(GGDEF) 		3 TYR A 233
LEU A 154
ARG A 232
 None
 0.77A 3sufB-3ignA:
undetectable		 3sufB-3ignA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A 490
LEU A  88
ARG A 484
 None
 0.68A 3sufB-3jq0A:
undetectable		 3sufB-3jq0A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A  93
LEU A  63
ARG A  75
 None
 0.65A 3sufB-3l22A:
undetectable		 3sufB-3l22A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		3 TYR A 142
LEU A 570
ARG A 604
 None
 0.79A 3sufB-3ne5A:
undetectable		 3sufB-3ne5A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 3 TYR A 362
LEU A 221
ARG A 359
 None
 0.56A 3sufB-3oy2A:
undetectable		 3sufB-3oy2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 TYR A 297
LEU A 262
ARG A 295
 PG4  A 411 (-4.1A)
None
None
 0.80A 3sufB-3qt4A:
undetectable		 3sufB-3qt4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		3 TYR B 229
LEU B 250
ARG B 228
 None
 0.72A 3sufB-3t5vB:
undetectable		 3sufB-3t5vB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		3 TYR A  54
LEU A  61
ARG A  51
 None
 0.81A 3sufB-3t7vA:
undetectable		 3sufB-3t7vA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl6 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Entamoeba
histolytica) 		PF01048
(PNP_UDP_1) 		3 TYR A  77
LEU A 236
ARG A  92
 None
None
SO4  A 239 (-3.2A)
 0.70A 3sufB-3tl6A:
undetectable		 3sufB-3tl6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9r ABSCISIC ACID
RECEPTOR PYL9

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		3 TYR A 160
LEU A 126
ARG A 167
 None
 0.71A 3sufB-3w9rA:
undetectable		 3sufB-3w9rA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 TYR A 673
LEU A 755
ARG A 827
 None
 0.69A 3sufB-3zifA:
undetectable		 3sufB-3zifA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrh UBIQUITIN
THIOESTERASE ZRANB1

(Homo sapiens) 		PF02338
(OTU) 		3 TYR A 373
LEU A 563
ARG A 534
 None
 0.81A 3sufB-3zrhA:
undetectable		 3sufB-3zrhA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		3 TYR A  93
LEU A  17
ARG A  99
 None
 0.79A 3sufB-4af5A:
undetectable		 3sufB-4af5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		3 TYR A  81
LEU A  68
ARG A  80
 None
 0.71A 3sufB-4anjA:
undetectable		 3sufB-4anjA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  32
LEU H  81
ARG H  99
 None
 0.80A 3sufB-4eowH:
undetectable		 3sufB-4eowH:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J

(Bacillus
subtilis) 		PF13424
(TPR_12) 		3 TYR A 108
LEU A  96
ARG A  59
 None
 0.64A 3sufB-4gyoA:
undetectable		 3sufB-4gyoA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		3 TYR A 170
LEU A 140
ARG A 114
 None
 0.75A 3sufB-4i93A:
undetectable		 3sufB-4i93A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		3 TYR A 267
LEU A 417
ARG A 358
 None
 0.67A 3sufB-4jrnA:
undetectable		 3sufB-4jrnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq7 HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF11175
(DUF2961) 		3 TYR A 263
LEU A 154
ARG A 333
 None
 0.80A 3sufB-4kq7A:
undetectable		 3sufB-4kq7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR B 428
LEU B 527
ARG B 642
 None
 0.80A 3sufB-4l37B:
undetectable		 3sufB-4l37B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A 481
LEU A  81
ARG A 475
 None
 0.58A 3sufB-4l7tA:
undetectable		 3sufB-4l7tA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE

(Acinetobacter
baumannii) 		PF00348
(polyprenyl_synt) 		3 TYR A 309
LEU A 201
ARG A 310
 None
GOL  A 401 (-4.2A)
None
 0.71A 3sufB-4lobA:
undetectable		 3sufB-4lobA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mru SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 TYR A 290
LEU A 338
ARG A 299
 None
 0.81A 3sufB-4mruA:
undetectable		 3sufB-4mruA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		3 TYR A 496
LEU A 468
ARG A 462
 None
 0.68A 3sufB-4nfuA:
undetectable		 3sufB-4nfuA:
15.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 TYR A  56
LEU A 135
ARG A 155
 None
2R8  A 301 (-4.4A)
2R8  A 301 (-3.6A)
 0.53A 3sufB-4nwkA:
35.1		 3sufB-4nwkA:
99.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68

(Chaetomium
thermophilum) 		PF16969
(SRP68) 		3 TYR A  20
LEU A  32
ARG A  24
 None
 0.76A 3sufB-4p3gA:
undetectable		 3sufB-4p3gA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5i CHEMOKINE BINDING
PROTEIN

(Orf virus) 		PF02250
(Orthopox_35kD) 		3 TYR A  26
LEU A 144
ARG A  28
 None
 0.64A 3sufB-4p5iA:
undetectable		 3sufB-4p5iA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 TYR A 181
LEU A 240
ARG A 177
 None
 0.72A 3sufB-4qavA:
undetectable		 3sufB-4qavA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgp PYROPHOSPHATASE

(Archaeoglobus
fulgidus) 		PF12643
(MazG-like) 		3 TYR A  20
LEU A  69
ARG A  12
 None
 0.76A 3sufB-4qgpA:
undetectable		 3sufB-4qgpA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 TYR B 994
LEU B 681
ARG B 996
 None
 0.66A 3sufB-4qiwB:
undetectable		 3sufB-4qiwB:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		3 TYR A 350
LEU A 477
ARG A 480
 None
 0.81A 3sufB-4qjyA:
undetectable		 3sufB-4qjyA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		3 TYR B 229
LEU B 250
ARG B 228
 None
 0.68A 3sufB-4trqB:
undetectable		 3sufB-4trqB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsh SURFACE PROTEIN
ADHESIN

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		3 TYR B1365
LEU B1422
ARG B1366
 None
 0.81A 3sufB-4tshB:
1.0		 3sufB-4tshB:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 TYR A 450
LEU A 502
ARG A 588
 None
 0.78A 3sufB-4um8A:
undetectable		 3sufB-4um8A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 TYR A 480
LEU A 492
ARG A 484
 None
 0.79A 3sufB-4uphA:
undetectable		 3sufB-4uphA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		3 TYR A 421
LEU A 463
ARG A 445
 None
 0.81A 3sufB-4xpdA:
undetectable		 3sufB-4xpdA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5

(Rattus
norvegicus) 		PF00083
(Sugar_tr) 		3 TYR A 218
LEU A 396
ARG A 217
 None
 0.79A 3sufB-4ybqA:
undetectable		 3sufB-4ybqA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR A 259
LEU A 247
ARG A 258
 None
 0.81A 3sufB-4yzwA:
undetectable		 3sufB-4yzwA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjh ALPHA-2-MACROGLOBULI
N

(Escherichia
coli) 		PF11974
(MG1) 		3 TYR A 299
LEU A 331
ARG A 298
 None
 0.75A 3sufB-4zjhA:
undetectable		 3sufB-4zjhA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 TYR A 202
LEU A 175
ARG A 206
 None
 0.80A 3sufB-5a8rA:
undetectable		 3sufB-5a8rA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ap9 LIPASE

(Thermomyces
lanuginosus) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		3 TYR A 194
LEU A 147
ARG A 195
 None
 0.56A 3sufB-5ap9A:
undetectable		 3sufB-5ap9A:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 TYR A1056
LEU A1135
ARG A1155
 SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
 0.30A 3sufB-5eqqA:
35.1		 3sufB-5eqqA:
94.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo sapiens) 		PF01853
(MOZ_SAS) 		3 TYR A 519
LEU A 580
ARG A 520
 None
 0.79A 3sufB-5gk9A:
undetectable		 3sufB-5gk9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyy S-RECEPTOR KINASE
SRK9

(Brassica rapa) 		PF00954
(S_locus_glycop)
PF01453
(B_lectin)
PF08276
(PAN_2) 		3 TYR A 228
LEU A 134
ARG A 230
 None
 0.72A 3sufB-5gyyA:
undetectable		 3sufB-5gyyA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h60 TRANSFERASE

(Escherichia
coli) 		no annotation 3 TYR A 190
LEU A  47
ARG A 191
 None
 0.60A 3sufB-5h60A:
undetectable		 3sufB-5h60A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 3 TYR B 210
LEU B 162
ARG B 154
 None
 0.69A 3sufB-5hzgB:
undetectable		 3sufB-5hzgB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00459
(Inositol_P) 		3 TYR A 133
LEU A 196
ARG A 134
 None
 0.69A 3sufB-5i3sA:
undetectable		 3sufB-5i3sA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12)
PF08625
(Utp13) 		3 TYR B 871
LEU A 873
ARG B 873
 None
 0.77A 3sufB-5ic9B:
undetectable		 3sufB-5ic9B:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 TYR A 365
LEU A  88
ARG A  72
 None
 0.73A 3sufB-5ju6A:
0.7		 3sufB-5ju6A:
13.81