SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUF_B_SUEB1201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8q BROMOPEROXIDASE A1

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		6 VAL A 226
HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 1.12A 3sufB-1a8qA:
undetectable		 3sufB-1a8qA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 VAL A 227
HIS A 253
ASP A 224
GLY A  27
SER A  94
 None
PPI  A 278 ( 4.0A)
None
PPI  A 278 ( 3.7A)
PPI  A 278 ( 2.7A)
 0.99A 3sufB-1a8sA:
undetectable		 3sufB-1a8sA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		5 GLY A 283
ILE A 332
GLY A 316
PHE A 275
ALA A 181
 None
 0.95A 3sufB-1aj8A:
undetectable		 3sufB-1aj8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8b SPORE PROTEASE

(Bacillus
megaterium) 		PF03418
(Peptidase_A25) 		5 VAL A 563
GLY A 565
ILE A 742
ALA A 534
ALA A 746
 None
 1.01A 3sufB-1c8bA:
undetectable		 3sufB-1c8bA:
18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		10 GLN A  41
PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.55A 3sufB-1cu1A:
34.8		 3sufB-1cu1A:
81.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		10 GLN A  41
PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 157
 None
 0.70A 3sufB-1cu1A:
34.8		 3sufB-1cu1A:
81.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnv GALLERIA MELLONELLA
DENSOVIRUS CAPSID
PROTEIN

(Lepidopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		5 GLN A  79
ILE A 251
GLY A 351
ALA A  74
ALA A 354
 None
 0.98A 3sufB-1dnvA:
undetectable		 3sufB-1dnvA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		5 ILE A  49
GLY A  59
SER A  62
ALA A 185
ALA A 187
 None
 0.97A 3sufB-1dy6A:
undetectable		 3sufB-1dy6A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		5 HIS A1280
GLY A1281
ILE A1286
GLY A1272
ALA A1212
 None
 1.01A 3sufB-1eg7A:
undetectable		 3sufB-1eg7A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		5 HIS A 282
ASP A 252
GLY A  82
SER A 155
ALA A 285
 EPE  A 455 (-4.0A)
None
EPE  A 455 (-3.5A)
EPE  A 455 (-1.4A)
None
 0.98A 3sufB-1evqA:
undetectable		 3sufB-1evqA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE

(Aspergillus
japonicus) 		no annotation 5 GLY A 329
ILE A 287
PHE A 276
ALA A 275
ALA A 301
 None
 1.01A 3sufB-1juhA:
undetectable		 3sufB-1juhA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		5 GLN H  61
HIS H  57
ASP H 102
GLY H 193
SER H 195
 None
 0.81A 3sufB-1kigH:
9.5		 3sufB-1kigH:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		10 GLN A  41
PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.68A 3sufB-1ns3A:
30.8		 3sufB-1ns3A:
78.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		6 GLN A  41
VAL A  55
HIS A  57
ASP A  81
GLY A 137
SER A 139
 None
 0.91A 3sufB-1ns3A:
30.8		 3sufB-1ns3A:
78.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		5 HIS A  47
ASP A  97
GLY A 169
SER A 171
ALA A 188
 None
 0.73A 3sufB-1p3cA:
10.4		 3sufB-1p3cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A 131
ILE A 171
GLY A 158
SER A 147
ALA A 149
 None
 0.99A 3sufB-1p9hA:
undetectable		 3sufB-1p9hA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0u BSTDEAD

(Geobacillus
stearothermophilus) 		PF00270
(DEAD) 		5 GLY A 166
ILE A 111
GLY A 135
ALA A  79
ALA A  85
 None
 1.01A 3sufB-1q0uA:
undetectable		 3sufB-1q0uA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 PHE A 145
GLY A 137
ILE A  77
ALA A 101
ALA A  79
 None
 0.97A 3sufB-1tufA:
undetectable		 3sufB-1tufA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 VAL A 273
GLY A 154
ILE A 136
GLY A 279
ALA A  58
 None
 0.81A 3sufB-1tvzA:
undetectable		 3sufB-1tvzA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		5 VAL A 618
GLY A 614
ILE A 548
ALA A 540
ALA A 541
 None
 1.00A 3sufB-1u2lA:
undetectable		 3sufB-1u2lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 GLY A 208
ILE A 181
GLY A  59
ALA A 199
ALA A 196
 None
 0.97A 3sufB-1v9cA:
undetectable		 3sufB-1v9cA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HSPBP1 PROTEIN

(Homo sapiens) 		PF08609
(Fes1) 		5 GLN A 225
VAL A 216
GLY A 222
ALA A 211
ALA A 208
 None
 0.98A 3sufB-1xqsA:
undetectable		 3sufB-1xqsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)

(Archaeoglobus
fulgidus) 		PF00590
(TP_methylase) 		5 GLY A  81
ILE A  21
GLY A   6
SER A  73
ALA A  70
 None
None
None
SAH  A 201 ( 4.1A)
None
 1.02A 3sufB-2bb3A:
undetectable		 3sufB-2bb3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		5 HIS A 281
ASP A 251
ILE A  95
GLY A  81
SER A 154
 None
 0.89A 3sufB-2c7bA:
undetectable		 3sufB-2c7bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eih ALCOHOL
DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 335
VAL A 181
GLY A 176
GLY A 314
ALA A  38
 None
 1.00A 3sufB-2eihA:
undetectable		 3sufB-2eihA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 GLY A  50
ILE A 214
GLY A 219
SER A  46
ALA A 158
 None
 0.98A 3sufB-2po4A:
undetectable		 3sufB-2po4A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxt LIPASE

(Bacillus
subtilis) 		PF01674
(Lipase_2) 		5 VAL A 136
HIS A 156
ASP A 133
GLY A  11
SER A  77
 None
 0.82A 3sufB-2qxtA:
undetectable		 3sufB-2qxtA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		5 GLY A 296
ILE A 315
GLY A  74
ALA A 256
ALA A 257
 None
 1.02A 3sufB-2uutA:
undetectable		 3sufB-2uutA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 HIS A  39
ASP A  77
GLY A 155
SER A 157
ALA A 174
 None
 0.74A 3sufB-2vidA:
12.1		 3sufB-2vidA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		5 PHE A 312
HIS A 141
ILE A 476
GLY A 315
ALA A 322
 None
None
None
NM2  A1505 (-2.5A)
None
 0.93A 3sufB-2wsxA:
undetectable		 3sufB-2wsxA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtn EST1E

(Butyrivibrio
proteoclasticus) 		PF08386
(Abhydrolase_4)
PF12146
(Hydrolase_4) 		5 VAL A 200
HIS A 225
ASP A 197
GLY A  32
SER A 105
 None
GOL  A1249 ( 4.8A)
None
GOL  A1249 ( 3.3A)
FER  A1250 ( 2.3A)
 0.96A 3sufB-2wtnA:
undetectable		 3sufB-2wtnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtn EST1E

(Butyrivibrio
proteoclasticus) 		PF08386
(Abhydrolase_4)
PF12146
(Hydrolase_4) 		6 VAL A 200
HIS A 225
ASP A 197
ILE A  42
GLY A 107
SER A 105
 None
GOL  A1249 ( 4.8A)
None
None
None
FER  A1250 ( 2.3A)
 1.40A 3sufB-2wtnA:
undetectable		 3sufB-2wtnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01083
(Cutinase) 		5 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 0.93A 3sufB-3ajaA:
undetectable		 3sufB-3ajaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 VAL A 123
HIS A 125
ASP A 153
GLY A 257
ALA A 281
 None
 0.63A 3sufB-3ak5A:
6.8		 3sufB-3ak5A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 VAL A 123
HIS A 125
ASP A 153
GLY A 257
SER A 259
 None
 0.78A 3sufB-3ak5A:
6.8		 3sufB-3ak5A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsx PUMILIO HOMOLOG 1

(Homo sapiens) 		PF00806
(PUF) 		5 GLN A 931
VAL A 937
GLY A 934
ALA A 889
ALA A 888
 None
 0.96A 3sufB-3bsxA:
undetectable		 3sufB-3bsxA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum) 		PF05448
(AXE1) 		5 PHE A 207
HIS A 301
ASP A 272
GLY A  90
SER A 182
 None
 0.99A 3sufB-3fcyA:
undetectable		 3sufB-3fcyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3d MATERNAL PROTEIN
PUMILIO

(Drosophila
melanogaster) 		PF00806
(PUF) 		5 GLN X 103
VAL X 109
GLY X 106
ALA X  61
ALA X  60
 None
 0.93A 3sufB-3h3dX:
undetectable		 3sufB-3h3dX:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		6 VAL A 225
HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 None
EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 1.16A 3sufB-3heaA:
undetectable		 3sufB-3heaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mep UNCHARACTERIZED
PROTEIN ECA2234

(Pectobacterium
atrosepticum) 		PF07081
(DUF1349) 		5 PHE A 165
VAL A  54
GLY A  56
ILE A 141
ALA A  94
 None
 0.89A 3sufB-3mepA:
undetectable		 3sufB-3mepA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngm EXTRACELLULAR LIPASE

(Fusarium
graminearum) 		PF01764
(Lipase_3) 		5 VAL A 200
HIS A 257
ASP A 198
GLY A  81
SER A 144
 None
 0.96A 3sufB-3ngmA:
undetectable		 3sufB-3ngmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		5 PHE A 395
ILE A 385
GLY A 391
SER A 437
ALA A 444
 None
 0.97A 3sufB-3nz4A:
undetectable		 3sufB-3nz4A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 PHE A 695
ASP A 733
GLY A 696
SER A 698
ALA A 712
 None
None
None
None
SEP  A 710 ( 4.2A)
 0.89A 3sufB-3ppzA:
undetectable		 3sufB-3ppzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 GLN A 389
HIS A 187
ASP A 140
GLY A 391
SER A 393
 None
 0.87A 3sufB-3qfhA:
undetectable		 3sufB-3qfhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 VAL A 191
HIS A 187
ASP A 140
GLY A 391
SER A 393
 None
 0.88A 3sufB-3qfhA:
undetectable		 3sufB-3qfhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		6 VAL A  33
GLY A  70
ILE A 136
SER A  67
PHE A  66
ALA A 122
 None
 1.45A 3sufB-3qk8A:
undetectable		 3sufB-3qk8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 461
ILE A 515
GLY A 547
ALA A 478
ALA A 479
 None
 0.90A 3sufB-3rimA:
undetectable		 3sufB-3rimA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.80A 3sufB-3s29A:
undetectable		 3sufB-3s29A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 287
GLY A 288
ASP A 417
GLY A 303
ALA A 439
 FRU  A 902 (-4.0A)
None
None
UDP  A 901 ( 2.9A)
FRU  A 902 ( 3.7A)
 0.92A 3sufB-3s29A:
undetectable		 3sufB-3s29A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 VAL A  96
HIS A  98
ASP A 140
GLY A 241
SER A 243
 None
 0.90A 3sufB-3syjA:
6.8		 3sufB-3syjA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		5 VAL A 205
HIS A 257
ASP A 203
GLY A  81
SER A 144
 None
 0.93A 3sufB-3tglA:
undetectable		 3sufB-3tglA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uuf LIP1, SECRETORY
LIPASE (FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		5 VAL A 230
HIS A 281
ASP A 228
GLY A 100
SER A 171
 None
 0.92A 3sufB-3uufA:
undetectable		 3sufB-3uufA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		5 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
 None
 1.00A 3sufB-3wj2A:
undetectable		 3sufB-3wj2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 VAL A 211
GLY A  44
ILE A 158
GLY A  82
ALA A 186
 ATP  A 501 (-4.1A)
ATP  A 501 ( 3.9A)
None
None
None
 0.98A 3sufB-3wquA:
undetectable		 3sufB-3wquA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 VAL A 211
GLY A  44
ILE A 158
GLY A  82
ALA A 186
 ATP  A 400 (-4.0A)
ATP  A 400 ( 4.0A)
None
None
None
 0.91A 3sufB-3wt0A:
undetectable		 3sufB-3wt0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyd LC-EST1C

(uncultured
organism) 		PF00326
(Peptidase_S9) 		5 HIS A 479
ASP A 447
GLY A 327
SER A 399
ALA A 483
 None
 0.91A 3sufB-3wydA:
undetectable		 3sufB-3wydA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgq NON-HEME
CHLOROPEROXIDASE

(Burkholderia
cenocepacia) 		PF00561
(Abhydrolase_1) 		5 VAL A 230
HIS A 256
ASP A 227
GLY A  30
SER A  97
 None
None
None
EDO  A 301 ( 4.0A)
EDO  A 301 (-2.4A)
 1.01A 3sufB-4dgqA:
undetectable		 3sufB-4dgqA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewf BETA-LACTAMASE

(Sphaerobacter
thermophilus) 		PF13354
(Beta-lactamase2) 		5 PHE A  45
GLY A  26
ILE A  53
ALA A 165
ALA A 167
 None
 0.95A 3sufB-4ewfA:
undetectable		 3sufB-4ewfA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbl LIPS LIPOLYTIC
ENZYME

(unidentified) 		PF12146
(Hydrolase_4) 		5 VAL A 230
HIS A 257
ASP A 227
GLY A  57
SER A 126
 None
SPD  A 301 (-3.2A)
None
SPD  A 301 (-3.5A)
SPD  A 301 ( 2.3A)
 0.89A 3sufB-4fblA:
undetectable		 3sufB-4fblA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		5 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.93A 3sufB-4fx5A:
undetectable		 3sufB-4fx5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 GLY A 185
ILE A 253
GLY A 247
SER A 245
ALA A 266
 None
 0.94A 3sufB-4h09A:
undetectable		 3sufB-4h09A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6w N-TERMINAL
CYANOBACTIN PROTEASE

(Planktothrix
agardhii) 		PF00082
(Peptidase_S8) 		5 VAL A  65
HIS A  61
ASP A  26
GLY A 219
ALA A 123
 None
 0.73A 3sufB-4h6wA:
undetectable		 3sufB-4h6wA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A  38
GLY A 272
SER A 752
ALA A 239
ALA A 236
 None
 0.99A 3sufB-4iigA:
undetectable		 3sufB-4iigA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j35 PHOSPHOTRIESTERASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF02126
(PTE) 		5 VAL A 128
GLY A 140
GLY A 170
ALA A 162
ALA A 163
 None
 1.00A 3sufB-4j35A:
undetectable		 3sufB-4j35A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		6 VAL A 310
HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.83A 3sufB-4mzdA:
undetectable		 3sufB-4mzdA:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		12 GLN A  41
PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 2R8  A 301 ( 3.5A)
2R8  A 301 (-4.6A)
None
2R8  A 301 (-3.3A)
2R8  A 301 (-3.5A)
2R8  A 301 (-3.6A)
2R8  A 301 (-4.3A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-2.6A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
 0.43A 3sufB-4nwkA:
35.1		 3sufB-4nwkA:
99.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 VAL A  70
HIS A  72
ASP A 101
GLY A 206
SER A 208
 None
 0.85A 3sufB-4om9A:
8.2		 3sufB-4om9A:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwv HIGH-AFFINITY
LEUCINE-SPECIFIC
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN, CHEMOTAXIS
PROTEIN CHEY

(Escherichia
coli;
Thermotoga
maritima) 		PF00072
(Response_reg)
PF13458
(Peripla_BP_6) 		5 PHE A  23
VAL A   7
GLY A   9
ALA A 275
ALA A 274
 None
 1.00A 3sufB-4qwvA:
undetectable		 3sufB-4qwvA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 273
GLY A 274
ASP A 404
GLY A 288
ALA A 426
 None
 0.86A 3sufB-4rbnA:
undetectable		 3sufB-4rbnA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 VAL A 228
HIS A 253
ASP A 225
GLY A  32
SER A 101
 None
None
None
PO4  A 301 ( 3.7A)
PO4  A 301 (-1.7A)
 0.99A 3sufB-4rncA:
undetectable		 3sufB-4rncA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.77A 3sufB-4x2xA:
10.3		 3sufB-4x2xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Nakamurella
multipartita) 		PF00561
(Abhydrolase_1) 		5 VAL A 250
HIS A 275
ASP A 247
GLY A  38
SER A 104
 None
 0.82A 3sufB-4y7dA:
undetectable		 3sufB-4y7dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y82 PROTEASOME SUBUNIT
BETA TYPE-7

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		6 PHE M 146
ILE M 177
GLY M 147
SER M  10
ALA M  24
ALA M  23
 None
 1.32A 3sufB-4y82M:
undetectable		 3sufB-4y82M:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a40 PUTATIVE FLUORIDE
ION TRANSPORTER CRCB

(Bordetella
pertussis) 		PF02537
(CRCB) 		5 GLY A  46
ILE A  12
GLY A  19
ALA A  71
ALA A  70
 None
 0.99A 3sufB-5a40A:
undetectable		 3sufB-5a40A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 HIS A 279
GLY A 280
ILE A 285
GLY A 271
ALA A 211
 None
 0.92A 3sufB-5a4jA:
undetectable		 3sufB-5a4jA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ap9 LIPASE

(Thermomyces
lanuginosus) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		5 VAL A 203
HIS A 258
ASP A 201
GLY A  82
SER A 146
 None
 0.83A 3sufB-5ap9A:
undetectable		 3sufB-5ap9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 VAL A 140
GLY A 144
ILE A 295
GLY A  98
SER A 101
 None
 0.93A 3sufB-5aw4A:
undetectable		 3sufB-5aw4A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		5 GLY A 524
ASP A 521
ILE A 561
GLY A 490
ALA A 529
 None
 1.01A 3sufB-5az4A:
undetectable		 3sufB-5az4A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN

(Burkholderia
cenocepacia) 		PF01032
(FecCD) 		5 VAL A 161
GLY A 180
ILE A 284
GLY A 114
ALA A 122
 None
 1.00A 3sufB-5b58A:
undetectable		 3sufB-5b58A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bra PUTATIVE PERIPLASMIC
BINDING PROTEIN WITH
SUBSTRATE RIBOSE

(Ochrobactrum
anthropi) 		PF13407
(Peripla_BP_4) 		5 GLN A 180
GLY A 173
ILE A 278
GLY A 233
ALA A 240
 None
 1.00A 3sufB-5braA:
undetectable		 3sufB-5braA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxu FERULIC ACID
ESTERASE AMCE1/FAE1A

(Anaeromyces
mucronatus) 		PF00756
(Esterase) 		5 VAL A 225
HIS A 253
ASP A 222
GLY A  64
SER A 156
 None
 0.86A 3sufB-5cxuA:
undetectable		 3sufB-5cxuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
 None
 1.02A 3sufB-5cykA:
undetectable		 3sufB-5cykA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwd ESTERASE

(Pelagibacterium
halotolerans) 		PF02230
(Abhydrolase_2) 		5 VAL A 172
HIS A 201
ASP A 169
GLY A  28
SER A 118
 None
 0.96A 3sufB-5dwdA:
undetectable		 3sufB-5dwdA:
23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		11 GLN A1041
PHE A1043
VAL A1055
HIS A1057
GLY A1058
ASP A1081
ILE A1132
GLY A1137
PHE A1154
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
None
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.30A 3sufB-5eqqA:
35.1		 3sufB-5eqqA:
94.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 5 GLY A 273
ILE A 225
GLY A 200
PHE A 229
ALA A 227
 None
 1.00A 3sufB-5f75A:
undetectable		 3sufB-5f75A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		5 VAL A 230
HIS A 281
ASP A 228
GLY A 100
SER A 171
 None
 0.97A 3sufB-5gw8A:
undetectable		 3sufB-5gw8A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		5 GLN A 277
GLY A 147
ILE A 195
ALA A 208
ALA A 207
 BEZ  A 401 (-3.9A)
None
None
None
None
 0.94A 3sufB-5im2A:
undetectable		 3sufB-5im2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 0.99A 3sufB-5kp7A:
undetectable		 3sufB-5kp7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		5 HIS A 281
ASP A 251
ILE A  97
GLY A  83
SER A 156
 None
 0.75A 3sufB-5l2pA:
undetectable		 3sufB-5l2pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 HIS A 317
ASP A 287
GLY A 117
SER A 190
ALA A 320
 None
 1.00A 3sufB-5mifA:
undetectable		 3sufB-5mifA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 5 VAL A 253
HIS A 284
ASP A 251
GLY A  37
SER A 114
 None
 0.95A 3sufB-5o7gA:
undetectable		 3sufB-5o7gA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 5 GLY A 273
ILE A 225
GLY A 200
PHE A 229
ALA A 227
 None
 0.96A 3sufB-5oexA:
undetectable		 3sufB-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		5 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.75A 3sufB-5to3B:
9.9		 3sufB-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 5 GLN A 104
VAL A 304
ILE A  39
GLY A  97
ALA A 150
 None
 0.81A 3sufB-5ub6A:
undetectable		 3sufB-5ub6A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
 None
 1.00A 3sufB-5vlhA:
undetectable		 3sufB-5vlhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
 None
 0.98A 3sufB-5vlhA:
undetectable		 3sufB-5vlhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 8 GLN A  41
PHE A  43
GLY A  58
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.76A 3sufB-5wdxA:
27.5		 3sufB-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 11 PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.49A 3sufB-5wdxA:
27.5		 3sufB-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avy ACYL-PROTEIN
THIOESTERASE 2

(Zea mays) 		no annotation 5 VAL A 200
HIS A 230
ASP A 197
GLY A  40
SER A 126
 None
 0.96A 3sufB-6avyA:
undetectable		 3sufB-6avyA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr -

(-) 		no annotation 5 PHE B 206
GLY B 139
ILE B 234
GLY B 221
ALA B 209
 None
 0.98A 3sufB-6dbrB:
undetectable		 3sufB-6dbrB:
undetectable