SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUF_B_SUEB1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8q BROMOPEROXIDASE A1

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		6 VAL A 226
HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 1.12A 3sufB-1a8qA:
undetectable		 3sufB-1a8qA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 VAL A 227
HIS A 253
ASP A 224
GLY A  27
SER A  94
 None
PPI  A 278 ( 4.0A)
None
PPI  A 278 ( 3.7A)
PPI  A 278 ( 2.7A)
 0.99A 3sufB-1a8sA:
undetectable		 3sufB-1a8sA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		5 GLY A 283
ILE A 332
GLY A 316
PHE A 275
ALA A 181
 None
 0.95A 3sufB-1aj8A:
undetectable		 3sufB-1aj8A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8b SPORE PROTEASE

(Bacillus
megaterium) 		PF03418
(Peptidase_A25) 		5 VAL A 563
GLY A 565
ILE A 742
ALA A 534
ALA A 746
 None
 1.01A 3sufB-1c8bA:
undetectable		 3sufB-1c8bA:
18.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		10 GLN A  41
PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.55A 3sufB-1cu1A:
34.8		 3sufB-1cu1A:
81.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		10 GLN A  41
PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 157
 None
 0.70A 3sufB-1cu1A:
34.8		 3sufB-1cu1A:
81.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnv GALLERIA MELLONELLA
DENSOVIRUS CAPSID
PROTEIN

(Lepidopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		5 GLN A  79
ILE A 251
GLY A 351
ALA A  74
ALA A 354
 None
 0.98A 3sufB-1dnvA:
undetectable		 3sufB-1dnvA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		5 ILE A  49
GLY A  59
SER A  62
ALA A 185
ALA A 187
 None
 0.97A 3sufB-1dy6A:
undetectable		 3sufB-1dy6A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		5 HIS A1280
GLY A1281
ILE A1286
GLY A1272
ALA A1212
 None
 1.01A 3sufB-1eg7A:
undetectable		 3sufB-1eg7A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		5 HIS A 282
ASP A 252
GLY A  82
SER A 155
ALA A 285
 EPE  A 455 (-4.0A)
None
EPE  A 455 (-3.5A)
EPE  A 455 (-1.4A)
None
 0.98A 3sufB-1evqA:
undetectable		 3sufB-1evqA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE

(Aspergillus
japonicus) 		no annotation 5 GLY A 329
ILE A 287
PHE A 276
ALA A 275
ALA A 301
 None
 1.01A 3sufB-1juhA:
undetectable		 3sufB-1juhA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		5 GLN H  61
HIS H  57
ASP H 102
GLY H 193
SER H 195
 None
 0.81A 3sufB-1kigH:
9.5		 3sufB-1kigH:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		10 GLN A  41
PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.68A 3sufB-1ns3A:
30.8		 3sufB-1ns3A:
78.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		6 GLN A  41
VAL A  55
HIS A  57
ASP A  81
GLY A 137
SER A 139
 None
 0.91A 3sufB-1ns3A:
30.8		 3sufB-1ns3A:
78.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		5 HIS A  47
ASP A  97
GLY A 169
SER A 171
ALA A 188
 None
 0.73A 3sufB-1p3cA:
10.4		 3sufB-1p3cA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A 131
ILE A 171
GLY A 158
SER A 147
ALA A 149
 None
 0.99A 3sufB-1p9hA:
undetectable		 3sufB-1p9hA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0u BSTDEAD

(Geobacillus
stearothermophilus) 		PF00270
(DEAD) 		5 GLY A 166
ILE A 111
GLY A 135
ALA A  79
ALA A  85
 None
 1.01A 3sufB-1q0uA:
undetectable		 3sufB-1q0uA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 PHE A 145
GLY A 137
ILE A  77
ALA A 101
ALA A  79
 None
 0.97A 3sufB-1tufA:
undetectable		 3sufB-1tufA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 VAL A 273
GLY A 154
ILE A 136
GLY A 279
ALA A  58
 None
 0.81A 3sufB-1tvzA:
undetectable		 3sufB-1tvzA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		5 VAL A 618
GLY A 614
ILE A 548
ALA A 540
ALA A 541
 None
 1.00A 3sufB-1u2lA:
undetectable		 3sufB-1u2lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 GLY A 208
ILE A 181
GLY A  59
ALA A 199
ALA A 196
 None
 0.97A 3sufB-1v9cA:
undetectable		 3sufB-1v9cA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqs HSPBP1 PROTEIN

(Homo sapiens) 		PF08609
(Fes1) 		5 GLN A 225
VAL A 216
GLY A 222
ALA A 211
ALA A 208
 None
 0.98A 3sufB-1xqsA:
undetectable		 3sufB-1xqsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)

(Archaeoglobus
fulgidus) 		PF00590
(TP_methylase) 		5 GLY A  81
ILE A  21
GLY A   6
SER A  73
ALA A  70
 None
None
None
SAH  A 201 ( 4.1A)
None
 1.02A 3sufB-2bb3A:
undetectable		 3sufB-2bb3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		5 HIS A 281
ASP A 251
ILE A  95
GLY A  81
SER A 154
 None
 0.89A 3sufB-2c7bA:
undetectable		 3sufB-2c7bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eih ALCOHOL
DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 335
VAL A 181
GLY A 176
GLY A 314
ALA A  38
 None
 1.00A 3sufB-2eihA:
undetectable		 3sufB-2eihA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 GLY A  50
ILE A 214
GLY A 219
SER A  46
ALA A 158
 None
 0.98A 3sufB-2po4A:
undetectable		 3sufB-2po4A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxt LIPASE

(Bacillus
subtilis) 		PF01674
(Lipase_2) 		5 VAL A 136
HIS A 156
ASP A 133
GLY A  11
SER A  77
 None
 0.82A 3sufB-2qxtA:
undetectable		 3sufB-2qxtA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		5 GLY A 296
ILE A 315
GLY A  74
ALA A 256
ALA A 257
 None
 1.02A 3sufB-2uutA:
undetectable		 3sufB-2uutA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 HIS A  39
ASP A  77
GLY A 155
SER A 157
ALA A 174
 None
 0.74A 3sufB-2vidA:
12.1		 3sufB-2vidA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		5 PHE A 312
HIS A 141
ILE A 476
GLY A 315
ALA A 322
 None
None
None
NM2  A1505 (-2.5A)
None
 0.93A 3sufB-2wsxA:
undetectable		 3sufB-2wsxA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtn EST1E

(Butyrivibrio
proteoclasticus) 		PF08386
(Abhydrolase_4)
PF12146
(Hydrolase_4) 		5 VAL A 200
HIS A 225
ASP A 197
GLY A  32
SER A 105
 None
GOL  A1249 ( 4.8A)
None
GOL  A1249 ( 3.3A)
FER  A1250 ( 2.3A)
 0.96A 3sufB-2wtnA:
undetectable		 3sufB-2wtnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtn EST1E

(Butyrivibrio
proteoclasticus) 		PF08386
(Abhydrolase_4)
PF12146
(Hydrolase_4) 		6 VAL A 200
HIS A 225
ASP A 197
ILE A  42
GLY A 107
SER A 105
 None
GOL  A1249 ( 4.8A)
None
None
None
FER  A1250 ( 2.3A)
 1.40A 3sufB-2wtnA:
undetectable		 3sufB-2wtnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01083
(Cutinase) 		5 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 0.93A 3sufB-3ajaA:
undetectable		 3sufB-3ajaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 VAL A 123
HIS A 125
ASP A 153
GLY A 257
ALA A 281
 None
 0.63A 3sufB-3ak5A:
6.8		 3sufB-3ak5A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 VAL A 123
HIS A 125
ASP A 153
GLY A 257
SER A 259
 None
 0.78A 3sufB-3ak5A:
6.8		 3sufB-3ak5A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsx PUMILIO HOMOLOG 1

(Homo sapiens) 		PF00806
(PUF) 		5 GLN A 931
VAL A 937
GLY A 934
ALA A 889
ALA A 888
 None
 0.96A 3sufB-3bsxA:
undetectable		 3sufB-3bsxA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum) 		PF05448
(AXE1) 		5 PHE A 207
HIS A 301
ASP A 272
GLY A  90
SER A 182
 None
 0.99A 3sufB-3fcyA:
undetectable		 3sufB-3fcyA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3d MATERNAL PROTEIN
PUMILIO

(Drosophila
melanogaster) 		PF00806
(PUF) 		5 GLN X 103
VAL X 109
GLY X 106
ALA X  61
ALA X  60
 None
 0.93A 3sufB-3h3dX:
undetectable		 3sufB-3h3dX:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		6 VAL A 225
HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 None
EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 1.16A 3sufB-3heaA:
undetectable		 3sufB-3heaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mep UNCHARACTERIZED
PROTEIN ECA2234

(Pectobacterium
atrosepticum) 		PF07081
(DUF1349) 		5 PHE A 165
VAL A  54
GLY A  56
ILE A 141
ALA A  94
 None
 0.89A 3sufB-3mepA:
undetectable		 3sufB-3mepA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngm EXTRACELLULAR LIPASE

(Fusarium
graminearum) 		PF01764
(Lipase_3) 		5 VAL A 200
HIS A 257
ASP A 198
GLY A  81
SER A 144
 None
 0.96A 3sufB-3ngmA:
undetectable		 3sufB-3ngmA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nz4 PHENYLALANINE
AMMONIA-LYASE

(Taxus
canadensis) 		PF00221
(Lyase_aromatic) 		5 PHE A 395
ILE A 385
GLY A 391
SER A 437
ALA A 444
 None
 0.97A 3sufB-3nz4A:
undetectable		 3sufB-3nz4A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 PHE A 695
ASP A 733
GLY A 696
SER A 698
ALA A 712
 None
None
None
None
SEP  A 710 ( 4.2A)
 0.89A 3sufB-3ppzA:
undetectable		 3sufB-3ppzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 GLN A 389
HIS A 187
ASP A 140
GLY A 391
SER A 393
 None
 0.87A 3sufB-3qfhA:
undetectable		 3sufB-3qfhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 VAL A 191
HIS A 187
ASP A 140
GLY A 391
SER A 393
 None
 0.88A 3sufB-3qfhA:
undetectable		 3sufB-3qfhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		6 VAL A  33
GLY A  70
ILE A 136
SER A  67
PHE A  66
ALA A 122
 None
 1.45A 3sufB-3qk8A:
undetectable		 3sufB-3qk8A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 461
ILE A 515
GLY A 547
ALA A 478
ALA A 479
 None
 0.90A 3sufB-3rimA:
undetectable		 3sufB-3rimA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.80A 3sufB-3s29A:
undetectable		 3sufB-3s29A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 287
GLY A 288
ASP A 417
GLY A 303
ALA A 439
 FRU  A 902 (-4.0A)
None
None
UDP  A 901 ( 2.9A)
FRU  A 902 ( 3.7A)
 0.92A 3sufB-3s29A:
undetectable		 3sufB-3s29A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 VAL A  96
HIS A  98
ASP A 140
GLY A 241
SER A 243
 None
 0.90A 3sufB-3syjA:
6.8		 3sufB-3syjA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		5 VAL A 205
HIS A 257
ASP A 203
GLY A  81
SER A 144
 None
 0.93A 3sufB-3tglA:
undetectable		 3sufB-3tglA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uuf LIP1, SECRETORY
LIPASE (FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		5 VAL A 230
HIS A 281
ASP A 228
GLY A 100
SER A 171
 None
 0.92A 3sufB-3uufA:
undetectable		 3sufB-3uufA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		5 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
 None
 1.00A 3sufB-3wj2A:
undetectable		 3sufB-3wj2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqu CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 VAL A 211
GLY A  44
ILE A 158
GLY A  82
ALA A 186
 ATP  A 501 (-4.1A)
ATP  A 501 ( 3.9A)
None
None
None
 0.98A 3sufB-3wquA:
undetectable		 3sufB-3wquA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA

(Staphylococcus
aureus) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 VAL A 211
GLY A  44
ILE A 158
GLY A  82
ALA A 186
 ATP  A 400 (-4.0A)
ATP  A 400 ( 4.0A)
None
None
None
 0.91A 3sufB-3wt0A:
undetectable		 3sufB-3wt0A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyd LC-EST1C

(uncultured
organism) 		PF00326
(Peptidase_S9) 		5 HIS A 479
ASP A 447
GLY A 327
SER A 399
ALA A 483
 None
 0.91A 3sufB-3wydA:
undetectable		 3sufB-3wydA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgq NON-HEME
CHLOROPEROXIDASE

(Burkholderia
cenocepacia) 		PF00561
(Abhydrolase_1) 		5 VAL A 230
HIS A 256
ASP A 227
GLY A  30
SER A  97
 None
None
None
EDO  A 301 ( 4.0A)
EDO  A 301 (-2.4A)
 1.01A 3sufB-4dgqA:
undetectable		 3sufB-4dgqA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewf BETA-LACTAMASE

(Sphaerobacter
thermophilus) 		PF13354
(Beta-lactamase2) 		5 PHE A  45
GLY A  26
ILE A  53
ALA A 165
ALA A 167
 None
 0.95A 3sufB-4ewfA:
undetectable		 3sufB-4ewfA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbl LIPS LIPOLYTIC
ENZYME

(unidentified) 		PF12146
(Hydrolase_4) 		5 VAL A 230
HIS A 257
ASP A 227
GLY A  57
SER A 126
 None
SPD  A 301 (-3.2A)
None
SPD  A 301 (-3.5A)
SPD  A 301 ( 2.3A)
 0.89A 3sufB-4fblA:
undetectable		 3sufB-4fblA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		5 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.93A 3sufB-4fx5A:
undetectable		 3sufB-4fx5A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 GLY A 185
ILE A 253
GLY A 247
SER A 245
ALA A 266
 None
 0.94A 3sufB-4h09A:
undetectable		 3sufB-4h09A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6w N-TERMINAL
CYANOBACTIN PROTEASE

(Planktothrix
agardhii) 		PF00082
(Peptidase_S8) 		5 VAL A  65
HIS A  61
ASP A  26
GLY A 219
ALA A 123
 None
 0.73A 3sufB-4h6wA:
undetectable		 3sufB-4h6wA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A  38
GLY A 272
SER A 752
ALA A 239
ALA A 236
 None
 0.99A 3sufB-4iigA:
undetectable		 3sufB-4iigA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j35 PHOSPHOTRIESTERASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF02126
(PTE) 		5 VAL A 128
GLY A 140
GLY A 170
ALA A 162
ALA A 163
 None
 1.00A 3sufB-4j35A:
undetectable		 3sufB-4j35A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		6 VAL A 310
HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.83A 3sufB-4mzdA:
undetectable		 3sufB-4mzdA:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		12 GLN A  41
PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 2R8  A 301 ( 3.5A)
2R8  A 301 (-4.6A)
None
2R8  A 301 (-3.3A)
2R8  A 301 (-3.5A)
2R8  A 301 (-3.6A)
2R8  A 301 (-4.3A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-2.6A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
 0.43A 3sufB-4nwkA:
35.1		 3sufB-4nwkA:
99.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 VAL A  70
HIS A  72
ASP A 101
GLY A 206
SER A 208
 None
 0.85A 3sufB-4om9A:
8.2		 3sufB-4om9A:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwv HIGH-AFFINITY
LEUCINE-SPECIFIC
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN, CHEMOTAXIS
PROTEIN CHEY

(Escherichia
coli;
Thermotoga
maritima) 		PF00072
(Response_reg)
PF13458
(Peripla_BP_6) 		5 PHE A  23
VAL A   7
GLY A   9
ALA A 275
ALA A 274
 None
 1.00A 3sufB-4qwvA:
undetectable		 3sufB-4qwvA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 273
GLY A 274
ASP A 404
GLY A 288
ALA A 426
 None
 0.86A 3sufB-4rbnA:
undetectable		 3sufB-4rbnA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 VAL A 228
HIS A 253
ASP A 225
GLY A  32
SER A 101
 None
None
None
PO4  A 301 ( 3.7A)
PO4  A 301 (-1.7A)
 0.99A 3sufB-4rncA:
undetectable		 3sufB-4rncA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.77A 3sufB-4x2xA:
10.3		 3sufB-4x2xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Nakamurella
multipartita) 		PF00561
(Abhydrolase_1) 		5 VAL A 250
HIS A 275
ASP A 247
GLY A  38
SER A 104
 None
 0.82A 3sufB-4y7dA:
undetectable		 3sufB-4y7dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y82 PROTEASOME SUBUNIT
BETA TYPE-7

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		6 PHE M 146
ILE M 177
GLY M 147
SER M  10
ALA M  24
ALA M  23
 None
 1.32A 3sufB-4y82M:
undetectable		 3sufB-4y82M:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a40 PUTATIVE FLUORIDE
ION TRANSPORTER CRCB

(Bordetella
pertussis) 		PF02537
(CRCB) 		5 GLY A  46
ILE A  12
GLY A  19
ALA A  71
ALA A  70
 None
 0.99A 3sufB-5a40A:
undetectable		 3sufB-5a40A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 HIS A 279
GLY A 280
ILE A 285
GLY A 271
ALA A 211
 None
 0.92A 3sufB-5a4jA:
undetectable		 3sufB-5a4jA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ap9 LIPASE

(Thermomyces
lanuginosus) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		5 VAL A 203
HIS A 258
ASP A 201
GLY A  82
SER A 146
 None
 0.83A 3sufB-5ap9A:
undetectable		 3sufB-5ap9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		5 VAL A 140
GLY A 144
ILE A 295
GLY A  98
SER A 101
 None
 0.93A 3sufB-5aw4A:
undetectable		 3sufB-5aw4A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		5 GLY A 524
ASP A 521
ILE A 561
GLY A 490
ALA A 529
 None
 1.01A 3sufB-5az4A:
undetectable		 3sufB-5az4A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b58 PUTATIVE HEMIN ABC
TRANSPORT SYSTEM,
MEMBRANE PROTEIN

(Burkholderia
cenocepacia) 		PF01032
(FecCD) 		5 VAL A 161
GLY A 180
ILE A 284
GLY A 114
ALA A 122
 None
 1.00A 3sufB-5b58A:
undetectable		 3sufB-5b58A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bra PUTATIVE PERIPLASMIC
BINDING PROTEIN WITH
SUBSTRATE RIBOSE

(Ochrobactrum
anthropi) 		PF13407
(Peripla_BP_4) 		5 GLN A 180
GLY A 173
ILE A 278
GLY A 233
ALA A 240
 None
 1.00A 3sufB-5braA:
undetectable		 3sufB-5braA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxu FERULIC ACID
ESTERASE AMCE1/FAE1A

(Anaeromyces
mucronatus) 		PF00756
(Esterase) 		5 VAL A 225
HIS A 253
ASP A 222
GLY A  64
SER A 156
 None
 0.86A 3sufB-5cxuA:
undetectable		 3sufB-5cxuA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
 None
 1.02A 3sufB-5cykA:
undetectable		 3sufB-5cykA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwd ESTERASE

(Pelagibacterium
halotolerans) 		PF02230
(Abhydrolase_2) 		5 VAL A 172
HIS A 201
ASP A 169
GLY A  28
SER A 118
 None
 0.96A 3sufB-5dwdA:
undetectable		 3sufB-5dwdA:
23.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		11 GLN A1041
PHE A1043
VAL A1055
HIS A1057
GLY A1058
ASP A1081
ILE A1132
GLY A1137
PHE A1154
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
None
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.30A 3sufB-5eqqA:
35.1		 3sufB-5eqqA:
94.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 5 GLY A 273
ILE A 225
GLY A 200
PHE A 229
ALA A 227
 None
 1.00A 3sufB-5f75A:
undetectable		 3sufB-5f75A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		5 VAL A 230
HIS A 281
ASP A 228
GLY A 100
SER A 171
 None
 0.97A 3sufB-5gw8A:
undetectable		 3sufB-5gw8A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		5 GLN A 277
GLY A 147
ILE A 195
ALA A 208
ALA A 207
 BEZ  A 401 (-3.9A)
None
None
None
None
 0.94A 3sufB-5im2A:
undetectable		 3sufB-5im2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 0.99A 3sufB-5kp7A:
undetectable		 3sufB-5kp7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		5 HIS A 281
ASP A 251
ILE A  97
GLY A  83
SER A 156
 None
 0.75A 3sufB-5l2pA:
undetectable		 3sufB-5l2pA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 HIS A 317
ASP A 287
GLY A 117
SER A 190
ALA A 320
 None
 1.00A 3sufB-5mifA:
undetectable		 3sufB-5mifA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 5 VAL A 253
HIS A 284
ASP A 251
GLY A  37
SER A 114
 None
 0.95A 3sufB-5o7gA:
undetectable		 3sufB-5o7gA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-) 		no annotation 5 GLY A 273
ILE A 225
GLY A 200
PHE A 229
ALA A 227
 None
 0.96A 3sufB-5oexA:
undetectable		 3sufB-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		5 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.75A 3sufB-5to3B:
9.9		 3sufB-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub6 PHOSPHATE-BINDING
PROTEIN

(Xanthomonas
citri) 		no annotation 5 GLN A 104
VAL A 304
ILE A  39
GLY A  97
ALA A 150
 None
 0.81A 3sufB-5ub6A:
undetectable		 3sufB-5ub6A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
 None
 1.00A 3sufB-5vlhA:
undetectable		 3sufB-5vlhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
 None
 0.98A 3sufB-5vlhA:
undetectable		 3sufB-5vlhA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 8 GLN A  41
PHE A  43
GLY A  58
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.76A 3sufB-5wdxA:
27.5		 3sufB-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 11 PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.49A 3sufB-5wdxA:
27.5		 3sufB-5wdxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avy ACYL-PROTEIN
THIOESTERASE 2

(Zea mays) 		no annotation 5 VAL A 200
HIS A 230
ASP A 197
GLY A  40
SER A 126
 None
 0.96A 3sufB-6avyA:
undetectable		 3sufB-6avyA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr -

(-) 		no annotation 5 PHE B 206
GLY B 139
ILE B 234
GLY B 221
ALA B 209
 None
 0.98A 3sufB-6dbrB:
undetectable		 3sufB-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3n PROTEIN (KETOACYL
ACYL CARRIER PROTEIN
SYNTHASE 2)

(Escherichia
coli) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 TYR A 179
LEU A 238
ARG A 175
 None
 0.79A 3sufB-1b3nA:
0.0		 3sufB-1b3nA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR 2

(Homo sapiens) 		PF00167
(FGF) 		3 TYR A 111
LEU A 138
ARG A 107
 None
 0.63A 3sufB-1fq9A:
0.0		 3sufB-1fq9A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 TYR A 110
LEU A  97
ARG A 109
 None
 0.76A 3sufB-1g8xA:
0.0		 3sufB-1g8xA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 TYR A 313
LEU A 230
ARG A 311
 None
 0.72A 3sufB-1i7oA:
0.0		 3sufB-1i7oA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 TYR A 100
LEU A 339
ARG A 344
 None
FAD  A 421 (-4.6A)
None
 0.76A 3sufB-1iqrA:
undetectable		 3sufB-1iqrA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR A 211
LEU A 199
ARG A 210
 None
 0.76A 3sufB-1llaA:
0.0		 3sufB-1llaA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5z AMPA RECEPTOR
INTERACTING PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		3 TYR A  68
LEU A  90
ARG A  70
 None
 0.55A 3sufB-1m5zA:
0.0		 3sufB-1m5zA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		3 TYR A  50
LEU A  29
ARG A  52
 None
None
XYP  A 601 ( 4.9A)
 0.79A 3sufB-1px8A:
0.0		 3sufB-1px8A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ucp APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF02758
(PYRIN) 		3 TYR A  36
LEU A  25
ARG A  38
 None
 0.50A 3sufB-1ucpA:
undetectable		 3sufB-1ucpA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjg PUTATIVE LIPASE FROM
THE G-D-S-L FAMILY

(Nostoc sp. PCC
7120) 		PF13472
(Lipase_GDSL_2) 		3 TYR A  47
LEU A 117
ARG A  71
 None
 0.69A 3sufB-1vjgA:
undetectable		 3sufB-1vjgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		3 TYR 1  72
LEU 1 493
ARG 1 101
 None
 0.80A 3sufB-1wao1:
undetectable		 3sufB-1wao1:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlo SUFE PROTEIN

(Thermus
thermophilus) 		PF02657
(SufE) 		3 TYR A 105
LEU A 114
ARG A 103
 None
 0.78A 3sufB-1wloA:
undetectable		 3sufB-1wloA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wsc HYPOTHETICAL PROTEIN
ST0229

(Sulfurisphaera
tokodaii) 		PF01871
(AMMECR1) 		3 TYR A  64
LEU A  20
ARG A 203
 None
 0.73A 3sufB-1wscA:
0.0		 3sufB-1wscA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc9 MULTIDRUG RESISTANCE
PROTEIN

(Vibrio cholerae) 		PF02321
(OEP) 		3 TYR A 200
LEU A 467
ARG A 198
 None
 0.71A 3sufB-1yc9A:
undetectable		 3sufB-1yc9A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zag PROTEIN
(ZINC-ALPHA-2-GLYCOP
ROTEIN)

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 TYR A  41
LEU A  36
ARG A  40
 None
 0.73A 3sufB-1zagA:
undetectable		 3sufB-1zagA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		3 TYR A  89
LEU A  20
ARG A  86
 None
None
EDO  A1408 ( 3.7A)
 0.69A 3sufB-1zl0A:
undetectable		 3sufB-1zl0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnl MODULATOR PROTEIN
RSBR

(Bacillus
subtilis) 		PF08678
(Rsbr_N) 		3 TYR A  96
LEU A  19
ARG A  94
 None
 0.74A 3sufB-2bnlA:
undetectable		 3sufB-2bnlA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		3 TYR A 175
LEU A 165
ARG A 174
 None
 0.67A 3sufB-2d0dA:
undetectable		 3sufB-2d0dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgx KIAA0430 PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		3 TYR A 596
LEU A 574
ARG A 565
 None
 0.80A 3sufB-2dgxA:
undetectable		 3sufB-2dgxA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		3 TYR A  29
LEU A 103
ARG A 448
 None
 0.81A 3sufB-2eceA:
undetectable		 3sufB-2eceA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7h METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF01035
(DNA_binding_1) 		3 TYR A 140
LEU A 122
ARG A 119
 None
 0.72A 3sufB-2g7hA:
undetectable		 3sufB-2g7hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		3 TYR A 248
LEU A 218
ARG A 249
 None
 0.76A 3sufB-2g9bA:
undetectable		 3sufB-2g9bA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		3 TYR A 109
LEU A 163
ARG A 103
 None
 0.74A 3sufB-2grmA:
undetectable		 3sufB-2grmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib0 CONSERVED
HYPOTHETICAL ALANINE
RICH PROTEIN

(Mycobacterium
tuberculosis) 		PF14530
(DUF4439) 		3 TYR A  38
LEU A  26
ARG A  66
 None
 0.79A 3sufB-2ib0A:
undetectable		 3sufB-2ib0A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izw RYEGRASS MOTTLE
VIRUS COAT PROTEIN

(Ryegrass mottle
virus) 		PF00729
(Viral_coat) 		3 TYR A 108
LEU A  89
ARG A  93
 None
 0.75A 3sufB-2izwA:
undetectable		 3sufB-2izwA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 TYR A 372
LEU A 357
ARG A 294
 None
None
COS  A1434 (-3.3A)
 0.81A 3sufB-2jifA:
undetectable		 3sufB-2jifA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR

(Burkholderia
pseudomallei) 		PF07487
(SopE_GEF) 		3 TYR A 205
LEU A 236
ARG A 207
 None
 0.79A 3sufB-2jokA:
undetectable		 3sufB-2jokA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		3 TYR A  36
LEU A  14
ARG A  38
 None
 0.81A 3sufB-2l7bA:
undetectable		 3sufB-2l7bA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la3 UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF06042
(NTP_transf_6) 		3 TYR A  91
LEU A  79
ARG A  85
 None
 0.74A 3sufB-2la3A:
undetectable		 3sufB-2la3A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 TYR A 387
LEU A 185
ARG A 343
 TYR  A 387 ( 1.3A)
LEU  A 185 ( 0.6A)
ARG  A 343 ( 0.6A)
 0.78A 3sufB-2nvvA:
undetectable		 3sufB-2nvvA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6i HD DOMAIN PROTEIN

(Enterococcus
faecalis) 		PF01966
(HD) 		3 TYR A 236
LEU A 204
ARG A 235
 None
 0.74A 3sufB-2o6iA:
undetectable		 3sufB-2o6iA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opc AVRL567-A

(Melampsora lini) 		PF11529
(AvrL567-A) 		3 TYR A 141
LEU A  68
ARG A  43
 None
 0.69A 3sufB-2opcA:
undetectable		 3sufB-2opcA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		3 TYR A 328
LEU A 402
ARG A 405
 None
None
GG9  A 501 (-3.9A)
 0.75A 3sufB-2pqdA:
undetectable		 3sufB-2pqdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpx PREDICTED
METAL-DEPENDENT
HYDROLASE OF THE
TIM-BARREL FOLD

(Lactobacillus
paracasei) 		PF04909
(Amidohydro_2) 		3 TYR A 273
LEU A 288
ARG A 269
 None
 0.73A 3sufB-2qpxA:
undetectable		 3sufB-2qpxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		3 TYR A  81
LEU A  68
ARG A  80
 None
 0.65A 3sufB-2v26A:
undetectable		 3sufB-2v26A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1q HYALURONOGLUCOSAMINI
DASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		3 TYR A 886
LEU A 826
ARG A 925
 None
 0.78A 3sufB-2w1qA:
undetectable		 3sufB-2w1qA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		3 TYR A 110
LEU A  63
ARG A 109
 None
 0.59A 3sufB-2y2wA:
undetectable		 3sufB-2y2wA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		3 TYR A 589
LEU A 618
ARG A 612
 None
 0.79A 3sufB-2yiaA:
undetectable		 3sufB-2yiaA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjt ATP-DEPENDENT RNA
HELICASE SRMB

(Escherichia
coli) 		PF00271
(Helicase_C) 		3 TYR D 227
LEU D 358
ARG D 228
 None
 0.76A 3sufB-2yjtD:
undetectable		 3sufB-2yjtD:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj4 GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING] 1

(Homo sapiens) 		PF01380
(SIS) 		3 TYR A 598
LEU A 552
ARG A 544
 None
 0.67A 3sufB-2zj4A:
undetectable		 3sufB-2zj4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I
PROGRAMMED CELL
DEATH PROTEIN 4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02847
(MA3) 		3 TYR B 409
LEU A 243
ARG B 407
 None
 0.76A 3sufB-2zu6B:
undetectable		 3sufB-2zu6B:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		3 TYR A 598
LEU A 590
ARG A 597
 None
 0.81A 3sufB-2zwaA:
undetectable		 3sufB-2zwaA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzr UNSATURATED
GLUCURONYL HYDROLASE

(Streptococcus
agalactiae) 		PF07470
(Glyco_hydro_88) 		3 TYR A 151
LEU A 119
ARG A 150
 None
 0.58A 3sufB-2zzrA:
undetectable		 3sufB-2zzrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE

(Bradyrhizobium
japonicum) 		PF00561
(Abhydrolase_1) 		3 TYR A  21
LEU A  51
ARG A  22
 None
 0.72A 3sufB-3a2lA:
undetectable		 3sufB-3a2lA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akf PUTATIVE SECRETED
ALPHA
L-ARABINOFURANOSIDAS
E II

(Streptomyces
avermitilis) 		PF04616
(Glyco_hydro_43)
PF05270
(AbfB) 		3 TYR A 384
LEU A 444
ARG A 436
 None
 0.79A 3sufB-3akfA:
undetectable		 3sufB-3akfA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		3 TYR A  54
LEU A 190
ARG A  56
 None
 0.81A 3sufB-3c4nA:
undetectable		 3sufB-3c4nA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		3 TYR A 160
LEU A 235
ARG A 157
 None
 0.65A 3sufB-3d5eA:
undetectable		 3sufB-3d5eA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ega PROTEIN PELLINO
HOMOLOG 2

(Homo sapiens) 		PF04710
(Pellino) 		3 TYR A 218
LEU A 245
ARG A 209
 None
 0.80A 3sufB-3egaA:
undetectable		 3sufB-3egaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3

(Homo sapiens) 		PF00782
(DSPc) 		3 TYR A  38
LEU A 151
ARG A 158
 None
 0.80A 3sufB-3f81A:
undetectable		 3sufB-3f81A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 TYR A 220
LEU A 368
ARG A 365
 None
 0.80A 3sufB-3gyrA:
undetectable		 3sufB-3gyrA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5g MYOSIN HEAVY CHAIN
ISOFORM A

(Doryteuthis
pealeii) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF02736
(Myosin_N) 		3 TYR A 107
LEU A  94
ARG A 106
 None
 0.77A 3sufB-3i5gA:
undetectable		 3sufB-3i5gA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ign DIGUANYLATE CYCLASE

(Marinobacter
hydrocarbonoclasticus) 		PF00990
(GGDEF) 		3 TYR A 233
LEU A 154
ARG A 232
 None
 0.77A 3sufB-3ignA:
undetectable		 3sufB-3ignA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A 490
LEU A  88
ARG A 484
 None
 0.68A 3sufB-3jq0A:
undetectable		 3sufB-3jq0A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A  93
LEU A  63
ARG A  75
 None
 0.65A 3sufB-3l22A:
undetectable		 3sufB-3l22A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		3 TYR A 142
LEU A 570
ARG A 604
 None
 0.79A 3sufB-3ne5A:
undetectable		 3sufB-3ne5A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 3 TYR A 362
LEU A 221
ARG A 359
 None
 0.56A 3sufB-3oy2A:
undetectable		 3sufB-3oy2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 TYR A 297
LEU A 262
ARG A 295
 PG4  A 411 (-4.1A)
None
None
 0.80A 3sufB-3qt4A:
undetectable		 3sufB-3qt4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5v NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		3 TYR B 229
LEU B 250
ARG B 228
 None
 0.72A 3sufB-3t5vB:
undetectable		 3sufB-3t5vB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		3 TYR A  54
LEU A  61
ARG A  51
 None
 0.81A 3sufB-3t7vA:
undetectable		 3sufB-3t7vA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl6 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Entamoeba
histolytica) 		PF01048
(PNP_UDP_1) 		3 TYR A  77
LEU A 236
ARG A  92
 None
None
SO4  A 239 (-3.2A)
 0.70A 3sufB-3tl6A:
undetectable		 3sufB-3tl6A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9r ABSCISIC ACID
RECEPTOR PYL9

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		3 TYR A 160
LEU A 126
ARG A 167
 None
 0.71A 3sufB-3w9rA:
undetectable		 3sufB-3w9rA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 TYR A 673
LEU A 755
ARG A 827
 None
 0.69A 3sufB-3zifA:
undetectable		 3sufB-3zifA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrh UBIQUITIN
THIOESTERASE ZRANB1

(Homo sapiens) 		PF02338
(OTU) 		3 TYR A 373
LEU A 563
ARG A 534
 None
 0.81A 3sufB-3zrhA:
undetectable		 3sufB-3zrhA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		3 TYR A  93
LEU A  17
ARG A  99
 None
 0.79A 3sufB-4af5A:
undetectable		 3sufB-4af5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4anj UNCONVENTIONAL
MYOSIN-VI, GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Sus scrofa) 		PF00063
(Myosin_head)
PF01353
(GFP) 		3 TYR A  81
LEU A  68
ARG A  80
 None
 0.71A 3sufB-4anjA:
undetectable		 3sufB-4anjA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  32
LEU H  81
ARG H  99
 None
 0.80A 3sufB-4eowH:
undetectable		 3sufB-4eowH:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyo RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE J

(Bacillus
subtilis) 		PF13424
(TPR_12) 		3 TYR A 108
LEU A  96
ARG A  59
 None
 0.64A 3sufB-4gyoA:
undetectable		 3sufB-4gyoA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i93 PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE
AT5G41260

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		3 TYR A 170
LEU A 140
ARG A 114
 None
 0.75A 3sufB-4i93A:
undetectable		 3sufB-4i93A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		3 TYR A 267
LEU A 417
ARG A 358
 None
 0.67A 3sufB-4jrnA:
undetectable		 3sufB-4jrnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kq7 HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF11175
(DUF2961) 		3 TYR A 263
LEU A 154
ARG A 333
 None
 0.80A 3sufB-4kq7A:
undetectable		 3sufB-4kq7A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR B 428
LEU B 527
ARG B 642
 None
 0.80A 3sufB-4l37B:
undetectable		 3sufB-4l37B:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 TYR A 481
LEU A  81
ARG A 475
 None
 0.58A 3sufB-4l7tA:
undetectable		 3sufB-4l7tA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lob POLYPRENYL
SYNTHETASE

(Acinetobacter
baumannii) 		PF00348
(polyprenyl_synt) 		3 TYR A 309
LEU A 201
ARG A 310
 None
GOL  A 401 (-4.2A)
None
 0.71A 3sufB-4lobA:
undetectable		 3sufB-4lobA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mru SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		3 TYR A 290
LEU A 338
ARG A 299
 None
 0.81A 3sufB-4mruA:
undetectable		 3sufB-4mruA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		3 TYR A 496
LEU A 468
ARG A 462
 None
 0.68A 3sufB-4nfuA:
undetectable		 3sufB-4nfuA:
15.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 TYR A  56
LEU A 135
ARG A 155
 None
2R8  A 301 (-4.4A)
2R8  A 301 (-3.6A)
 0.53A 3sufB-4nwkA:
35.1		 3sufB-4nwkA:
99.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3g SIGNAL RECOGNITION
PARTICLE SUBUNIT
SRP68

(Chaetomium
thermophilum) 		PF16969
(SRP68) 		3 TYR A  20
LEU A  32
ARG A  24
 None
 0.76A 3sufB-4p3gA:
undetectable		 3sufB-4p3gA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5i CHEMOKINE BINDING
PROTEIN

(Orf virus) 		PF02250
(Orthopox_35kD) 		3 TYR A  26
LEU A 144
ARG A  28
 None
 0.64A 3sufB-4p5iA:
undetectable		 3sufB-4p5iA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 TYR A 181
LEU A 240
ARG A 177
 None
 0.72A 3sufB-4qavA:
undetectable		 3sufB-4qavA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgp PYROPHOSPHATASE

(Archaeoglobus
fulgidus) 		PF12643
(MazG-like) 		3 TYR A  20
LEU A  69
ARG A  12
 None
 0.76A 3sufB-4qgpA:
undetectable		 3sufB-4qgpA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 TYR B 994
LEU B 681
ARG B 996
 None
 0.66A 3sufB-4qiwB:
undetectable		 3sufB-4qiwB:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		3 TYR A 350
LEU A 477
ARG A 480
 None
 0.81A 3sufB-4qjyA:
undetectable		 3sufB-4qjyA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI) 		3 TYR B 229
LEU B 250
ARG B 228
 None
 0.68A 3sufB-4trqB:
undetectable		 3sufB-4trqB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsh SURFACE PROTEIN
ADHESIN

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		3 TYR B1365
LEU B1422
ARG B1366
 None
 0.81A 3sufB-4tshB:
1.0		 3sufB-4tshB:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		3 TYR A 450
LEU A 502
ARG A 588
 None
 0.78A 3sufB-4um8A:
undetectable		 3sufB-4um8A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 TYR A 480
LEU A 492
ARG A 484
 None
 0.79A 3sufB-4uphA:
undetectable		 3sufB-4uphA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		3 TYR A 421
LEU A 463
ARG A 445
 None
 0.81A 3sufB-4xpdA:
undetectable		 3sufB-4xpdA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5

(Rattus
norvegicus) 		PF00083
(Sugar_tr) 		3 TYR A 218
LEU A 396
ARG A 217
 None
 0.79A 3sufB-4ybqA:
undetectable		 3sufB-4ybqA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 TYR A 259
LEU A 247
ARG A 258
 None
 0.81A 3sufB-4yzwA:
undetectable		 3sufB-4yzwA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjh ALPHA-2-MACROGLOBULI
N

(Escherichia
coli) 		PF11974
(MG1) 		3 TYR A 299
LEU A 331
ARG A 298
 None
 0.75A 3sufB-4zjhA:
undetectable		 3sufB-4zjhA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		3 TYR A 202
LEU A 175
ARG A 206
 None
 0.80A 3sufB-5a8rA:
undetectable		 3sufB-5a8rA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ap9 LIPASE

(Thermomyces
lanuginosus) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		3 TYR A 194
LEU A 147
ARG A 195
 None
 0.56A 3sufB-5ap9A:
undetectable		 3sufB-5ap9A:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 TYR A1056
LEU A1135
ARG A1155
 SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
 0.30A 3sufB-5eqqA:
35.1		 3sufB-5eqqA:
94.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gk9 HISTONE
ACETYLTRANSFERASE
KAT7

(Homo sapiens) 		PF01853
(MOZ_SAS) 		3 TYR A 519
LEU A 580
ARG A 520
 None
 0.79A 3sufB-5gk9A:
undetectable		 3sufB-5gk9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyy S-RECEPTOR KINASE
SRK9

(Brassica rapa) 		PF00954
(S_locus_glycop)
PF01453
(B_lectin)
PF08276
(PAN_2) 		3 TYR A 228
LEU A 134
ARG A 230
 None
 0.72A 3sufB-5gyyA:
undetectable		 3sufB-5gyyA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h60 TRANSFERASE

(Escherichia
coli) 		no annotation 3 TYR A 190
LEU A  47
ARG A 191
 None
 0.60A 3sufB-5h60A:
undetectable		 3sufB-5h60A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 3 TYR B 210
LEU B 162
ARG B 154
 None
 0.69A 3sufB-5hzgB:
undetectable		 3sufB-5hzgB:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3s INOSITOL
MONOPHOSPHATASE
FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00459
(Inositol_P) 		3 TYR A 133
LEU A 196
ARG A 134
 None
 0.69A 3sufB-5i3sA:
undetectable		 3sufB-5i3sA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12)
PF08625
(Utp13) 		3 TYR B 871
LEU A 873
ARG B 873
 None
 0.77A 3sufB-5ic9B:
undetectable		 3sufB-5ic9B:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 TYR A 365
LEU A  88
ARG A  72
 None
 0.73A 3sufB-5ju6A:
0.7		 3sufB-5ju6A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides) 		PF00485
(PRK) 		4 SER A 229
ARG A 208
PRO A 156
VAL A 157
 None
 1.13A 3sufC-1a7jA:
0.0		 3sufC-1a7jA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aqk FAB B7-15A2

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  85
ARG H  87
PRO H  88
VAL H 121
 None
 1.12A 3sufC-1aqkH:
undetectable		 3sufC-1aqkH:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b2w PROTEIN (ANTIBODY
(HEAVY CHAIN))

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  85
ARG H  87
PRO H  88
VAL H 115
 None
 1.29A 3sufC-1b2wH:
0.0		 3sufC-1b2wH:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg5 FUSION PROTEIN OF
ALPHA-NA,K-ATPASE
WITH GLUTATHIONE
S-TRANSFERASE

(Rattus
norvegicus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 SER A 226
ARG A 224
PRO A 223
VAL A 222
 None
 1.01A 3sufC-1bg5A:
undetectable		 3sufC-1bg5A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 SER A 447
PRO A 387
TYR A 388
VAL A 433
 None
 1.15A 3sufC-1bhgA:
0.5		 3sufC-1bhgA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		4 SER A 534
PRO A 516
TYR A 603
VAL A 515
 None
 1.31A 3sufC-1c4kA:
undetectable		 3sufC-1c4kA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 SER A 438
ARG A 448
TYR A 315
VAL A 272
 None
 1.30A 3sufC-1ciyA:
0.1		 3sufC-1ciyA:
15.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 SER A 128
ARG A 130
PRO A 131
TYR A 134
VAL A 163
 None
 0.61A 3sufC-1cu1A:
34.0		 3sufC-1cu1A:
81.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8n ANTI-PLATELET
PROTEIN

(Haementeria
officinalis) 		no annotation 4 SER A  48
ARG A  50
PRO A  51
VAL A 117
 None
 1.43A 3sufC-1i8nA:
undetectable		 3sufC-1i8nA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2b ARCHAEOSINE
TRNA-GUANINE
TRANSGLYCOSYLASE

(Pyrococcus
horikoshii) 		PF01472
(PUA)
PF01702
(TGT)
PF14809
(TGT_C1)
PF14810
(TGT_C2) 		4 SER A 185
ARG A 224
PRO A 225
VAL A 226
 None
 1.29A 3sufC-1j2bA:
0.0		 3sufC-1j2bA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		4 SER A  59
PRO A  52
TYR A  50
VAL A  53
 None
None
ACR  A 598 (-4.5A)
None
 1.25A 3sufC-1kxhA:
undetectable		 3sufC-1kxhA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw7 TRANSCRIPTIONAL
REGULATOR NADR

(Haemophilus
influenzae) 		PF01467
(CTP_transf_like)
PF13521
(AAA_28) 		4 ARG A 117
PRO A  69
TYR A  68
VAL A  70
 None
 1.40A 3sufC-1lw7A:
undetectable		 3sufC-1lw7A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md6 INTERLEUKIN 1
FAMILY, MEMBER 5
(DELTA)

(Mus musculus) 		PF00340
(IL1) 		4 SER A  42
PRO A  45
TYR A  88
VAL A  56
 None
 1.35A 3sufC-1md6A:
undetectable		 3sufC-1md6A:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 SER A 128
ARG A 130
PRO A 131
VAL A 163
 None
 1.10A 3sufC-1ns3A:
29.8		 3sufC-1ns3A:
78.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qni NITROUS-OXIDE
REDUCTASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 4 SER A 201
PRO A 269
TYR A 204
VAL A 265
 None
 1.41A 3sufC-1qniA:
undetectable		 3sufC-1qniA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN

(Pseudomonas
aeruginosa) 		PF13433
(Peripla_BP_5) 		4 SER A 235
PRO A 255
TYR A 256
VAL A 253
 None
 1.25A 3sufC-1qnlA:
undetectable		 3sufC-1qnlA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1n FERRIC-IRON BINDING
PROTEIN

(Neisseria
gonorrhoeae) 		PF01547
(SBP_bac_1) 		4 SER A 228
ARG A 101
TYR A 195
VAL A 225
 None
None
CNB  A 400 (-4.8A)
None
 1.36A 3sufC-1r1nA:
undetectable		 3sufC-1r1nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 SER B 506
PRO B 249
TYR B  33
VAL B 248
 MCN  B4921 (-2.6A)
None
None
None
 1.30A 3sufC-1t3qB:
undetectable		 3sufC-1t3qB:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpg T-PLASMINOGEN
ACTIVATOR F1-G

(Homo sapiens) 		PF00008
(EGF)
PF00039
(fn1) 		4 SER A  28
ARG A  30
PRO A  47
VAL A  48
 None
 1.43A 3sufC-1tpgA:
undetectable		 3sufC-1tpgA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vke CARBOXYMUCONOLACTONE
DECARBOXYLASE FAMILY
PROTEIN

(Thermotoga
maritima) 		PF02627
(CMD) 		4 SER A  33
ARG A  37
PRO A  38
VAL A  43
 None
 1.03A 3sufC-1vkeA:
undetectable		 3sufC-1vkeA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfy RAP1/RAP2
INTERACTING PROTEIN
REGULATOR OF
G-PROTEIN SIGNALING
14

(Mus musculus) 		PF02196
(RBD) 		4 SER A  33
ARG A  16
PRO A  36
VAL A  75
 None
 1.39A 3sufC-1wfyA:
undetectable		 3sufC-1wfyA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz2 LEUCYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 SER A 147
ARG A 148
PRO A  77
VAL A 144
 None
 1.34A 3sufC-1wz2A:
undetectable		 3sufC-1wz2A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		4 ARG A  95
PRO A  96
TYR A  50
VAL A  86
 None
 0.99A 3sufC-2bs9A:
undetectable		 3sufC-2bs9A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2g THREONINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 SER A 364
ARG A 367
TYR A 301
VAL A 369
 None
 1.41A 3sufC-2c2gA:
undetectable		 3sufC-2c2gA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2doc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3) 		4 SER A  37
PRO A  21
TYR A  22
VAL A  91
 None
 1.40A 3sufC-2docA:
undetectable		 3sufC-2docA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e4u METABOTROPIC
GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		4 SER A 175
PRO A 192
TYR A 196
VAL A 191
 None
 1.42A 3sufC-2e4uA:
undetectable		 3sufC-2e4uA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		4 SER A 120
ARG A 123
PRO A 126
VAL A 125
 None
 1.35A 3sufC-2ftpA:
undetectable		 3sufC-2ftpA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz6 ENDOPLASMIC
RETICULUM TO NUCLEUS
SIGNALLING 1 ISOFORM
1 VARIANT

(Homo sapiens) 		PF13360
(PQQ_2) 		4 SER A  41
PRO A 225
TYR A 289
VAL A 226
 None
 1.36A 3sufC-2hz6A:
0.4		 3sufC-2hz6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jll NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 SER A 515
PRO A 499
TYR A 500
VAL A 569
 None
 1.19A 3sufC-2jllA:
undetectable		 3sufC-2jllA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 SER A 429
ARG A 416
PRO A 415
VAL A 414
 None
None
GOL  A1914 ( 4.6A)
GOL  A1914 (-4.2A)
 1.16A 3sufC-2vcaA:
undetectable		 3sufC-2vcaA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjr PROBABLE
N-ACETYLNEURAMINIC
ACID OUTER MEMBRANE
CHANNEL PROTEIN NANC

(Escherichia
coli) 		PF06178
(KdgM) 		4 SER A  93
ARG A  72
PRO A  73
VAL A  90
 EPE  A1217 ( 4.7A)
EPE  A1217 (-3.7A)
None
None
 1.31A 3sufC-2wjrA:
undetectable		 3sufC-2wjrA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 SER A 515
PRO A 499
TYR A 500
VAL A 569
 None
 1.23A 3sufC-2xycA:
undetectable		 3sufC-2xycA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 SER A 446
PRO A 450
TYR A 449
VAL A 476
 None
 1.41A 3sufC-2yikA:
undetectable		 3sufC-2yikA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z13 EF-HAND
DOMAIN-CONTAINING
FAMILY MEMBER C2

(Homo sapiens) 		PF06565
(DUF1126) 		4 SER A  17
PRO A  45
TYR A  44
VAL A  86
 None
 1.30A 3sufC-2z13A:
undetectable		 3sufC-2z13A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 SER A 653
PRO A 631
TYR A 599
VAL A 632
 None
 1.40A 3sufC-3a0fA:
undetectable		 3sufC-3a0fA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 SER A  71
ARG A  73
PRO A  74
VAL A  46
 None
 1.01A 3sufC-3af5A:
undetectable		 3sufC-3af5A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Geobacillus
kaustophilus) 		PF00551
(Formyl_trans_N) 		4 SER A   9
ARG A  38
PRO A  39
VAL A  56
 None
 1.39A 3sufC-3av3A:
undetectable		 3sufC-3av3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi NANOBODY NBEPSIJ_11

(Lama glama) 		PF07686
(V-set) 		4 SER C  84
ARG C  86
PRO C  87
VAL C 115
 None
 1.36A 3sufC-3cfiC:
undetectable		 3sufC-3cfiC:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fve DIAMINOPIMELATE
EPIMERASE

(Mycobacterium
tuberculosis) 		PF01678
(DAP_epimerase) 		4 SER A 113
ARG A 118
PRO A 119
VAL A 110
 None
None
None
GOL  A 291 (-3.5A)
 1.33A 3sufC-3fveA:
undetectable		 3sufC-3fveA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy6 INTEGRON CASSETTE
PROTEIN

(Vibrio cholerae) 		no annotation 4 SER A  10
PRO A  65
TYR A  64
VAL A 101
 None
 0.92A 3sufC-3fy6A:
undetectable		 3sufC-3fy6A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		4 SER A 156
PRO A 203
TYR A 205
VAL A 202
 None
 1.31A 3sufC-3hxkA:
undetectable		 3sufC-3hxkA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		4 ARG M  66
PRO M  63
TYR M  61
VAL M  64
 None
 1.08A 3sufC-3i04M:
undetectable		 3sufC-3i04M:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		4 SER A 153
PRO A 146
TYR A 131
VAL A 145
 None
 1.24A 3sufC-3jr3A:
undetectable		 3sufC-3jr3A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2m MONOBODY HA4

(Homo sapiens) 		PF00041
(fn3) 		4 SER C  60
PRO C  56
TYR C  57
VAL C  55
 None
 1.26A 3sufC-3k2mC:
undetectable		 3sufC-3k2mC:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kez PUTATIVE SUGAR
BINDING PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 SER A  58
ARG A  64
TYR A  88
VAL A  66
 None
EDO  A   8 (-3.3A)
None
None
 1.33A 3sufC-3kezA:
undetectable		 3sufC-3kezA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX RNA-BINDING
PROTEIN 1

(Sulfolobus
solfataricus) 		no annotation 4 SER C 136
PRO C 139
TYR C  96
VAL C 140
 None
 1.36A 3sufC-3l7zC:
undetectable		 3sufC-3l7zC:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE

(Listeria
monocytogenes) 		PF00198
(2-oxoacid_dh) 		4 SER A 322
PRO A 292
TYR A 290
VAL A 293
 None
 1.39A 3sufC-3maeA:
undetectable		 3sufC-3maeA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw3 AMINOPEPTIDASE C

(Parabacteroides
distasonis) 		PF03051
(Peptidase_C1_2) 		4 SER A 104
ARG A  92
TYR A  89
VAL A 153
 None
 1.39A 3sufC-3pw3A:
undetectable		 3sufC-3pw3A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 SER A1515
PRO A1171
TYR A1172
VAL A1169
 None
 1.18A 3sufC-3topA:
undetectable		 3sufC-3topA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		4 SER A 119
ARG A 123
PRO A 124
VAL A 145
 None
PO4  A 440 (-2.9A)
PO4  A 443 (-4.4A)
None
 1.22A 3sufC-3tr1A:
undetectable		 3sufC-3tr1A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uet ALPHA-1,3/4-FUCOSIDA
SE

(Bifidobacterium
longum) 		PF01120
(Alpha_L_fucos) 		4 SER A 227
ARG A 212
PRO A 230
VAL A 275
 None
 1.34A 3sufC-3uetA:
undetectable		 3sufC-3uetA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upu ATP-DEPENDENT DNA
HELICASE DDA

(Escherichia
virus T4) 		PF13604
(AAA_30) 		4 SER A 402
ARG A 433
TYR A 434
VAL A 436
 None
 0.98A 3sufC-3upuA:
undetectable		 3sufC-3upuA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		4 SER A1045
ARG A 908
TYR A1012
VAL A 872
 None
 1.28A 3sufC-3vuoA:
undetectable		 3sufC-3vuoA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ARG B 858
PRO B 859
TYR B 861
VAL B 683
 None
 1.39A 3sufC-4f92B:
undetectable		 3sufC-4f92B:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Mus musculus) 		PF05028
(PARG_cat) 		4 SER A 466
ARG A 468
PRO A 469
VAL A 475
 SO4  A1001 (-3.0A)
SO4  A1001 (-3.1A)
None
None
 0.87A 3sufC-4fc2A:
undetectable		 3sufC-4fc2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 SER B 200
ARG B 169
PRO B 171
VAL B 172
 None
 1.30A 3sufC-4gnkB:
undetectable		 3sufC-4gnkB:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grw NANOBODY 22E11

(Lama glama) 		PF07686
(V-set) 		4 SER H  85
ARG H  87
PRO H  88
VAL H 121
 None
 1.11A 3sufC-4grwH:
undetectable		 3sufC-4grwH:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hao PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Yersinia pestis) 		PF01513
(NAD_kinase) 		4 SER A 123
PRO A 272
TYR A 275
VAL A 116
 None
 1.40A 3sufC-4haoA:
undetectable		 3sufC-4haoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio) 		PF00659
(POLO_box) 		4 SER B 430
ARG B 432
TYR B 501
VAL B 425
 None
 1.38A 3sufC-4j7bB:
undetectable		 3sufC-4j7bB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		4 SER A 170
ARG A 168
TYR A 204
VAL A 184
 173  A 401 (-2.6A)
173  A 401 (-2.8A)
None
None
 1.28A 3sufC-4mniA:
undetectable		 3sufC-4mniA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		4 SER A 425
PRO A 430
TYR A 450
VAL A 447
 None
 1.41A 3sufC-4n0iA:
undetectable		 3sufC-4n0iA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n54 INOSITOL
DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ARG A 290
PRO A 266
TYR A 247
VAL A 265
 None
None
2H3  A 402 (-4.5A)
None
 1.39A 3sufC-4n54A:
undetectable		 3sufC-4n54A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqa LIVER X NUCLEAR
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		4 SER B 380
ARG B 383
PRO B 384
VAL B 386
 None
 1.42A 3sufC-4nqaB:
undetectable		 3sufC-4nqaB:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 ARG A 130
PRO A 131
TYR A 134
VAL A 163
 None
 0.71A 3sufC-4nwkA:
35.2		 3sufC-4nwkA:
99.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 SER A 128
PRO A 131
TYR A 134
VAL A 163
 None
 0.85A 3sufC-4nwkA:
35.2		 3sufC-4nwkA:
99.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwv CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		4 SER A 366
PRO A 364
TYR A 381
VAL A 363
 None
 1.41A 3sufC-4nwvA:
undetectable		 3sufC-4nwvA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nww CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		4 SER A 366
PRO A 364
TYR A 381
VAL A 363
 None
 1.40A 3sufC-4nwwA:
undetectable		 3sufC-4nwwA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1

(Sicarius
terrosus) 		no annotation 4 SER A 227
PRO A 250
TYR A  22
VAL A 253
 None
 1.34A 3sufC-4q6xA:
undetectable		 3sufC-4q6xA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6x PHOSPHOLIPASE D
STSICTOX-BETAIC1

(Sicarius
terrosus) 		no annotation 4 SER A 227
PRO A 250
TYR A 249
VAL A 253
 None
 1.35A 3sufC-4q6xA:
undetectable		 3sufC-4q6xA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		4 SER A  19
PRO A 102
TYR A 137
VAL A 101
 None
 1.23A 3sufC-4qwwA:
undetectable		 3sufC-4qwwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5z PUTATIVE
PHENYLALANINE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 SER A  29
ARG A 322
PRO A 323
VAL A 329
 SIN  A 401 (-2.7A)
SIN  A 401 (-3.0A)
None
None
 1.18A 3sufC-4r5zA:
undetectable		 3sufC-4r5zA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm4 CYTOCHROME P450

(Bacillus
subtilis) 		PF00067
(p450) 		4 SER A 316
PRO A 287
TYR A 387
VAL A 288
 None
 1.42A 3sufC-4rm4A:
undetectable		 3sufC-4rm4A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubd MONOCLONAL ANTIBODY
H CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER C  85
ARG C  87
PRO C  88
VAL C 124
 None
 1.12A 3sufC-4ubdC:
undetectable		 3sufC-4ubdC:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uml GANGLIOSIDE-INDUCED
DIFFERENTIATION-ASSO
CIATED PROTEIN 2

(Homo sapiens) 		PF01661
(Macro) 		4 SER A 147
PRO A 131
TYR A 176
VAL A 129
 None
 1.39A 3sufC-4umlA:
undetectable		 3sufC-4umlA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wik SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH

(Homo sapiens) 		PF00076
(RRM_1)
PF08075
(NOPS) 		4 SER A 379
ARG A 443
PRO A 444
VAL A 445
 None
 1.37A 3sufC-4wikA:
undetectable		 3sufC-4wikA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 4 SER A 385
PRO A 416
TYR A 271
VAL A 415
 None
 1.41A 3sufC-4y9vA:
undetectable		 3sufC-4y9vA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg3 OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 4 SER A  87
ARG A 162
TYR A 137
VAL A  92
 SO4  A 303 (-4.9A)
SO4  A 303 ( 3.0A)
None
None
 1.40A 3sufC-4yg3A:
undetectable		 3sufC-4yg3A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		4 SER A 411
PRO A 418
TYR A 417
VAL A  95
 None
 0.78A 3sufC-4zzqA:
undetectable		 3sufC-4zzqA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6h CSUC

(Acinetobacter
baumannii) 		PF00345
(PapD_N) 		4 SER A 117
PRO A  10
TYR A   9
VAL A  21
 None
 1.36A 3sufC-5d6hA:
undetectable		 3sufC-5d6hA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5en6 SMU-1

(Caenorhabditis
elegans) 		no annotation 4 SER A 120
ARG A 124
PRO A 125
TYR A 126
 None
 1.41A 3sufC-5en6A:
undetectable		 3sufC-5en6A:
22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 SER A1128
ARG A1130
PRO A1131
VAL A1163
 None
 0.53A 3sufC-5eqqA:
33.9		 3sufC-5eqqA:
94.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fji BETA-GLUCOSIDASE

(Aspergillus
fumigatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A  79
PRO A 712
TYR A 711
VAL A  60
 NAG  A1001 (-2.7A)
None
NAG  A1002 ( 4.3A)
None
 1.33A 3sufC-5fjiA:
undetectable		 3sufC-5fjiA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq0 EPITHIOSPECIFIER
PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 SER B 275
ARG B 242
TYR B 200
VAL B 244
 None
 1.16A 3sufC-5gq0B:
undetectable		 3sufC-5gq0B:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 SER A 464
PRO A 461
TYR A 253
VAL A 453
 None
BLA  A 601 ( 4.6A)
BLA  A 601 (-4.4A)
None
 1.28A 3sufC-5i5lA:
undetectable		 3sufC-5i5lA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtw COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 SER B 893
ARG B 895
PRO B 896
VAL B 854
 None
 1.05A 3sufC-5jtwB:
undetectable		 3sufC-5jtwB:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A  79
PRO A 704
TYR A 703
VAL A  60
 NAG  A 901 (-2.8A)
None
NAG  A 902 (-4.4A)
None
 1.35A 3sufC-5ju6A:
undetectable		 3sufC-5ju6A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 SER A 565
ARG A 567
PRO A 568
TYR A 569
 None
 1.30A 3sufC-5l9wA:
undetectable		 3sufC-5l9wA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 SER A 565
ARG A 567
TYR A 569
VAL A 400
 None
 1.17A 3sufC-5l9wA:
undetectable		 3sufC-5l9wA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lbs BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8

(Homo sapiens) 		PF07686
(V-set) 		4 SER H  82
ARG H  83
PRO H  84
VAL H 111
 None
 1.11A 3sufC-5lbsH:
undetectable		 3sufC-5lbsH:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		4 SER A1035
PRO A1041
TYR A1044
VAL A1840
 None
 1.34A 3sufC-5lkiA:
undetectable		 3sufC-5lkiA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6p TYROCIDINE SYNTHASE
2

(Brevibacillus
parabrevis) 		no annotation 4 SER A3475
PRO A3419
TYR A3418
VAL A3390
 None
 1.34A 3sufC-5m6pA:
undetectable		 3sufC-5m6pA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		4 SER A 367
ARG A 332
PRO A 370
VAL A 394
 None
PTR  A 372 ( 2.6A)
None
None
 1.38A 3sufC-5mqsA:
undetectable		 3sufC-5mqsA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		4 SER A  98
ARG A 101
TYR A 102
VAL A 104
 None
 1.24A 3sufC-5mtzA:
undetectable		 3sufC-5mtzA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzv NANOBODY 22E11

(Lama glama) 		no annotation 4 SER D  85
ARG D  87
PRO D  88
VAL D 121
 None
 1.04A 3sufC-5mzvD:
undetectable		 3sufC-5mzvD:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 SER A 154
PRO A 176
TYR A 379
VAL A 175
 None
 1.05A 3sufC-5w4bA:
undetectable		 3sufC-5w4bA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES25

(Toxoplasma
gondii) 		PF03297
(Ribosomal_S25) 		4 SER Z 127
ARG Z 130
PRO Z 115
TYR Z 153
 C  21531 ( 2.5A)
C  21531 ( 2.8A)
None
None
 1.37A 3sufC-5xxuZ:
undetectable		 3sufC-5xxuZ:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 4 SER A 219
PRO A 273
TYR A 188
VAL A 274
 None
 1.36A 3sufC-5yl7A:
undetectable		 3sufC-5yl7A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 SER A 357
ARG A 355
TYR A 498
VAL A 376
 None
 1.28A 3sufC-6b6lA:
undetectable		 3sufC-6b6lA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE DELTA
SUBUNIT

(Trypanosoma
brucei) 		no annotation 4 SER H 106
ARG H  34
PRO H  49
VAL H  50
 None
 1.41A 3sufC-6f5dH:
undetectable		 3sufC-6f5dH:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2

(Mus musculus) 		no annotation 4 ARG d  51
PRO d  52
TYR O 308
VAL d  53
 None
None
None
3PE  M 506 (-4.3A)
 1.33A 3sufC-6g2jd:
undetectable		 3sufC-6g2jd:
20.00