SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUE_D_SUED1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aqz RESTRICTOCIN

(Aspergillus
restrictus) 		no annotation 3 TYR A 125
LEU A  61
LYS A  60
 None
 0.61A 3sueD-1aqzA:
undetectable		 3sueD-1aqzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bj8 GP130

(Homo sapiens) 		PF00041
(fn3) 		3 TYR A  45
LEU A  39
LYS A  40
 None
 0.78A 3sueD-1bj8A:
0.0		 3sueD-1bj8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmv HUMAN
CYTOMEGALOVIRUS
PROTEASE

(Human
betaherpesvirus
5) 		PF00716
(Peptidase_S21) 		3 TYR A 128
LEU A 244
LYS A 242
 None
 0.66A 3sueD-1cmvA:
0.0		 3sueD-1cmvA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctm CYTOCHROME F

(Brassica rapa) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		3 TYR A 190
LEU A 223
LYS A 222
 None
 0.74A 3sueD-1ctmA:
0.0		 3sueD-1ctmA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1et9 SUPERANTIGEN SPE-H

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 TYR A 173
LEU A 137
LYS A 136
 None
 0.48A 3sueD-1et9A:
0.0		 3sueD-1et9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fon PROCARBOXYPEPTIDASE
A-S6

(Bos taurus) 		PF00089
(Trypsin) 		3 TYR A 128
LEU A  63
LYS A 144
 None
 0.78A 3sueD-1fonA:
9.0		 3sueD-1fonA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5g FUSION PROTEIN

(Avian
avulavirus 1) 		PF00523
(Fusion_gly) 		3 TYR A 239
LEU A  65
LYS A  64
 None
 0.77A 3sueD-1g5gA:
0.0		 3sueD-1g5gA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		3 TYR A1268
LEU A1207
LYS A1209
 None
 0.76A 3sueD-1jl5A:
0.0		 3sueD-1jl5A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 TYR A 301
LEU A 124
LYS A 127
 None
 0.72A 3sueD-1lpfA:
0.0		 3sueD-1lpfA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 TYR H  54
LEU H  65
LYS H  66
 None
 0.73A 3sueD-1mcoH:
undetectable		 3sueD-1mcoH:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 TYR A 253
LEU A 309
LYS A 310
 None
 0.65A 3sueD-1olpA:
1.1		 3sueD-1olpA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		3 TYR A 230
LEU A 218
LYS A 219
 None
 0.44A 3sueD-1r2fA:
undetectable		 3sueD-1r2fA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG

(Homo sapiens) 		PF03657
(UPF0113) 		3 TYR A  95
LEU A 114
LYS A 115
 None
 0.71A 3sueD-1sqwA:
undetectable		 3sueD-1sqwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uv4 ARABINAN-ENDO
1,5-ALPHA-L-ARABINAS
E

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		3 TYR A  80
LEU A  40
LYS A  41
 None
 0.64A 3sueD-1uv4A:
undetectable		 3sueD-1uv4A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		3 TYR A 235
LEU A 223
LYS A 224
 None
CIT  A1294 (-4.5A)
None
 0.36A 3sueD-1uzrA:
undetectable		 3sueD-1uzrA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Sulfurisphaera
tokodaii) 		PF00294
(PfkB) 		3 TYR A 107
LEU A 116
LYS A 115
 None
 0.70A 3sueD-1wyeA:
undetectable		 3sueD-1wyeA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE

(Rattus
norvegicus) 		no annotation 3 TYR A 136
LEU A 112
LYS A 113
 None
 0.58A 3sueD-1xcjA:
undetectable		 3sueD-1xcjA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1w TRICORN PROTEASE
INTERACTING FACTOR
F3

(Thermoplasma
acidophilum) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 TYR A 364
LEU A 378
LYS A 376
 None
 0.70A 3sueD-1z1wA:
undetectable		 3sueD-1z1wA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2

(Rattus
norvegicus) 		PF03114
(BAR) 		3 TYR A 170
LEU A 158
LYS A 159
 None
 0.71A 3sueD-2c08A:
undetectable		 3sueD-2c08A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		3 TYR A 307
LEU A 319
LYS A 317
 None
 0.49A 3sueD-2cybA:
undetectable		 3sueD-2cybA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana) 		PF02204
(VPS9) 		3 TYR A  85
LEU A 156
LYS A 155
 None
 0.70A 3sueD-2efeA:
undetectable		 3sueD-2efeA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		3 TYR X 176
LEU X 164
LYS X 165
 None
 0.76A 3sueD-2f6hX:
undetectable		 3sueD-2f6hX:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		3 TYR A 304
LEU A 146
LYS A 147
 None
 0.61A 3sueD-2f8tA:
undetectable		 3sueD-2f8tA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0i THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBG

(Escherichia
coli) 		PF13098
(Thioredoxin_2) 		3 TYR A 111
LEU A 169
LYS A 168
 None
 0.74A 3sueD-2h0iA:
undetectable		 3sueD-2h0iA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrh TRANSCRIPTIONAL
ACTIVATOR, PUTATIVE,
BAF FAMILY

(Campylobacter
jejuni) 		PF03309
(Pan_kinase) 		3 TYR A  80
LEU A 169
LYS A 168
 None
 0.75A 3sueD-2nrhA:
undetectable		 3sueD-2nrhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		3 TYR A 114
LEU A 314
LYS A 313
 PO4  A 805 (-4.4A)
None
None
 0.65A 3sueD-2o4vA:
undetectable		 3sueD-2o4vA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otu FV HEAVY CHAIN
VARIABLE DOMAIN

(Mus musculus) 		PF07686
(V-set) 		3 TYR B  35
LEU B  18
LYS B  19
 None
 0.78A 3sueD-2otuB:
undetectable		 3sueD-2otuB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT

(Bacillus sp. D6) 		PF09491
(RE_AlwI) 		3 TYR A  20
LEU A  32
LYS A  30
 None
None
GOL  A 195 ( 4.6A)
 0.75A 3sueD-2p14A:
undetectable		 3sueD-2p14A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		3 TYR A 467
LEU A 452
LYS A 453
 None
 0.64A 3sueD-2pq6A:
undetectable		 3sueD-2pq6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		3 TYR A 328
LEU A 367
LYS A 366
 None
 0.71A 3sueD-2pqdA:
undetectable		 3sueD-2pqdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptt CD48 ANTIGEN

(Mus musculus) 		PF07686
(V-set) 		3 TYR A  47
LEU A  19
LYS A  20
 None
 0.70A 3sueD-2pttA:
undetectable		 3sueD-2pttA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 TYR A 602
LEU A 726
LYS A 725
 None
 0.66A 3sueD-2q1fA:
undetectable		 3sueD-2q1fA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qga ADENYLOSUCCINATE
LYASE

(Plasmodium
vivax) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		3 TYR B 350
LEU B 362
LYS B 360
 None
 0.74A 3sueD-2qgaB:
undetectable		 3sueD-2qgaB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 TYR A 287
LEU A 299
LYS A 297
 None
 0.76A 3sueD-2rgwA:
undetectable		 3sueD-2rgwA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN

(Shigella
flexneri) 		PF00497
(SBP_bac_3) 		3 TYR A  46
LEU A  58
LYS A  56
 None
 0.78A 3sueD-2vhaA:
undetectable		 3sueD-2vhaA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk9 ALPHA-TOXIN

(Clostridium
novyi) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		3 TYR A 133
LEU A 249
LYS A 250
 None
 0.70A 3sueD-2vk9A:
undetectable		 3sueD-2vk9A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		3 TYR A 376
LEU A 299
LYS A 296
 None
 0.78A 3sueD-2xryA:
undetectable		 3sueD-2xryA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al8 SEMAPHORIN-6A

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		3 TYR A 228
LEU A 182
LYS A 181
 None
 0.67A 3sueD-3al8A:
undetectable		 3sueD-3al8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg2 DGTP
TRIPHOSPHOHYDROLASE

(Leeuwenhoekiella
blandensis) 		PF01966
(HD) 		3 TYR A 210
LEU A 230
LYS A 231
 None
 0.76A 3sueD-3bg2A:
undetectable		 3sueD-3bg2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		3 TYR A  31
LEU A  82
LYS A  81
 None
 0.78A 3sueD-3bolA:
undetectable		 3sueD-3bolA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btp SINGLE-STRAND
DNA-BINDING PROTEIN

(Agrobacterium
fabrum) 		PF07229
(VirE2) 		3 TYR A 117
LEU A 307
LYS A 308
 None
 0.75A 3sueD-3btpA:
undetectable		 3sueD-3btpA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 3 TYR B1046
LEU B1069
LYS B1070
 None
 0.67A 3sueD-3cqcB:
undetectable		 3sueD-3cqcB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		3 TYR A 424
LEU A 479
LYS A 480
 None
 0.67A 3sueD-3cuxA:
undetectable		 3sueD-3cuxA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmp URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Burkholderia
pseudomallei) 		PF14681
(UPRTase) 		3 TYR A  48
LEU A 185
LYS A 184
 None
 0.71A 3sueD-3dmpA:
undetectable		 3sueD-3dmpA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhn PROTEIN TRANSPORT
PROTEIN TIP20

(Saccharomyces
cerevisiae) 		PF04437
(RINT1_TIP1) 		3 TYR A 637
LEU A 624
LYS A 622
 None
 0.74A 3sueD-3fhnA:
undetectable		 3sueD-3fhnA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fot 15-O-ACETYLTRANSFERA
SE

(Fusarium
sporotrichioides) 		PF07428
(Tri3) 		3 TYR A  54
LEU A  74
LYS A  75
 None
None
SO4  A 528 ( 3.8A)
 0.79A 3sueD-3fotA:
undetectable		 3sueD-3fotA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gh8 IODOTYROSINE
DEHALOGENASE 1

(Mus musculus) 		PF00881
(Nitroreductase) 		3 TYR A 208
LEU A 255
LYS A 254
 None
 0.63A 3sueD-3gh8A:
undetectable		 3sueD-3gh8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		3 TYR A 192
LEU A 235
LYS A 234
 None
 0.75A 3sueD-3h8lA:
undetectable		 3sueD-3h8lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3A

(Saccharomyces
cerevisiae) 		PF00411
(Ribosomal_S11) 		3 TYR o 179
LEU o  68
LYS o  69
 None
 0.75A 3sueD-3japo:
undetectable		 3sueD-3japo:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		3 TYR B 656
LEU B 618
LYS B 616
 None
 0.78A 3sueD-3jb9B:
undetectable		 3sueD-3jb9B:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10
PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF16004
(EFTUD2) 		3 TYR A 337
LEU B 618
LYS B 616
 None
 0.72A 3sueD-3jb9A:
undetectable		 3sueD-3jb9A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 TYR A 470
LEU A 482
LYS A 481
 None
None
A  C  35 ( 3.0A)
 0.59A 3sueD-3jb9A:
undetectable		 3sueD-3jb9A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE

(Listeria
monocytogenes) 		PF00563
(EAL) 		3 TYR A 165
LEU A  96
LYS A  97
 None
 0.73A 3sueD-3kzpA:
undetectable		 3sueD-3kzpA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		3 TYR A  31
LEU A  44
LYS A  42
 None
 0.78A 3sueD-3lkdA:
undetectable		 3sueD-3lkdA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llq AQUAPORIN Z 2

(Agrobacterium
fabrum) 		PF00230
(MIP) 		3 TYR A  52
LEU A   6
LYS A   4
 None
 0.79A 3sueD-3llqA:
undetectable		 3sueD-3llqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 3 TYR B 230
LEU B 218
LYS B 219
 None
 0.42A 3sueD-3n3bB:
undetectable		 3sueD-3n3bB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		3 TYR A 225
LEU A   9
LYS A  10
 FMT  A 754 (-4.2A)
None
None
 0.78A 3sueD-3nnmA:
0.0		 3sueD-3nnmA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		3 TYR A 248
LEU A  83
LYS A  81
 None
 0.71A 3sueD-3o75A:
undetectable		 3sueD-3o75A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		3 TYR A 173
LEU A 199
LYS A 197
 None
 0.79A 3sueD-3s51A:
undetectable		 3sueD-3s51A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 TYR A 642
LEU A 602
LYS A 601
 None
 0.78A 3sueD-3sdqA:
undetectable		 3sueD-3sdqA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uai H/ACA
RIBONUCLEOPROTEIN
COMPLEX SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04410
(Gar1) 		3 TYR C  62
LEU C  69
LYS C  72
 None
 0.79A 3sueD-3uaiC:
4.2		 3sueD-3uaiC:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzv ANTI-DENGUE MAB 4E11

(Mus musculus) 		PF07686
(V-set) 		3 TYR B  34
LEU B   4
LYS B   3
 None
 0.79A 3sueD-3uzvB:
1.4		 3sueD-3uzvB:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5i FERROUS IRON
TRANSPORT PROTEIN B

(Gallionella
capsiferriformans) 		PF02421
(FeoB_N) 		3 TYR A 163
LEU A 102
LYS A 103
 None
 0.55A 3sueD-3w5iA:
undetectable		 3sueD-3w5iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		3 TYR A 155
LEU A 167
LYS A 165
 None
 0.74A 3sueD-3zgqA:
undetectable		 3sueD-3zgqA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh2 L-LACTATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 TYR A 161
LEU A 189
LYS A 190
 None
 0.77A 3sueD-3zh2A:
undetectable		 3sueD-3zh2A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl0 CELL CYCLE ARREST
PROTEIN BUB3

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 TYR A 110
LEU A  82
LYS A  83
 None
 0.70A 3sueD-4bl0A:
undetectable		 3sueD-4bl0A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blf SINGLE-STRAND
DNA-BINDING PROTEIN

(Agrobacterium
tumefaciens) 		PF07229
(VirE2) 		3 TYR A 117
LEU A 307
LYS A 308
 None
 0.75A 3sueD-4blfA:
undetectable		 3sueD-4blfA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT) 		3 TYR A 642
LEU A 706
LYS A 704
 None
None
SO4  A2004 ( 3.7A)
 0.73A 3sueD-4bujA:
undetectable		 3sueD-4bujA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		3 TYR A 216
LEU A 122
LYS A 121
 None
 0.67A 3sueD-4c2lA:
undetectable		 3sueD-4c2lA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czd PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ASNC
FAMILY

(Desulfovibrio
desulfuricans) 		PF13404
(HTH_AsnC-type)
no annotation 		3 TYR B 111
LEU A 160
LYS A 159
 None
 0.69A 3sueD-4czdB:
undetectable		 3sueD-4czdB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 TYR A 859
LEU A1022
LYS A1020
 None
 0.67A 3sueD-4fxdA:
undetectable		 3sueD-4fxdA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE

(Francisella
philomiragia) 		PF01048
(PNP_UDP_1) 		3 TYR A  24
LEU A 224
LYS A 223
 None
 0.76A 3sueD-4josA:
undetectable		 3sueD-4josA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbx UNCHARACTERIZED
PROTEIN YHFX

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		3 TYR A  86
LEU A 150
LYS A 151
 None
 0.60A 3sueD-4kbxA:
0.9		 3sueD-4kbxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		3 TYR A 519
LEU A 542
LYS A 543
 None
 0.60A 3sueD-4mboA:
undetectable		 3sueD-4mboA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		3 TYR A 279
LEU A 290
LYS A 289
 None
 0.60A 3sueD-4n0rA:
undetectable		 3sueD-4n0rA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 TYR A 537
LEU A 567
LYS A 565
 None
GOL  A 906 (-3.4A)
None
 0.74A 3sueD-4nhoA:
undetectable		 3sueD-4nhoA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nps BARTONELLA EFFECTOR
PROTEIN (BEP)
SUBSTRATE OF VIRB
T4SS

(Bartonella
clarridgeiae) 		PF02661
(Fic) 		3 TYR A 166
LEU A  76
LYS A  74
 None
 0.77A 3sueD-4npsA:
undetectable		 3sueD-4npsA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		3 TYR A 701
LEU A 669
LYS A 668
 None
 0.77A 3sueD-4q8hA:
0.4		 3sueD-4q8hA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 TYR A 480
LEU A 492
LYS A 490
 None
 0.69A 3sueD-4uphA:
undetectable		 3sueD-4uphA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv6 ALPHAREP-7

(synthetic
construct) 		PF13646
(HEAT_2) 		3 TYR A 160
LEU A 100
LYS A 102
 None
 0.73A 3sueD-4zv6A:
undetectable		 3sueD-4zv6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aum HEAVY CHAIN OF FAB
FRAGMENT

(Rattus) 		no annotation 3 TYR H  35
LEU H  18
LYS H  19
 None
 0.78A 3sueD-5aumH:
undetectable		 3sueD-5aumH:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 TYR A 404
LEU A  89
LYS A  87
 None
EDO  A 505 (-4.4A)
None
 0.64A 3sueD-5e4rA:
undetectable		 3sueD-5e4rA:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 TYR A1056
LEU A1135
LYS A1136
 SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
 0.44A 3sueD-5eqqA:
33.9		 3sueD-5eqqA:
93.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5p RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 3 TYR C 851
LEU C 863
LYS C 861
 None
 0.78A 3sueD-5f5pC:
undetectable		 3sueD-5f5pC:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5frd CARBOXYLESTERASE
(EST-2)

(Archaeoglobus
fulgidus) 		PF12697
(Abhydrolase_6) 		3 TYR A 207
LEU A  98
LYS A  97
 COA  A1257 (-3.4A)
None
None
 0.71A 3sueD-5frdA:
undetectable		 3sueD-5frdA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		3 TYR F 609
LEU F 502
LYS F 500
 None
 0.75A 3sueD-5gjwF:
undetectable		 3sueD-5gjwF:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		3 TYR A 404
LEU A 117
LYS A 116
 None
 0.62A 3sueD-5hs1A:
undetectable		 3sueD-5hs1A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j0a LYMPHOKINE-ACTIVATED
KILLER
T-CELL-ORIGINATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 156
LEU A 144
LYS A 145
 None
 0.76A 3sueD-5j0aA:
undetectable		 3sueD-5j0aA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcf MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		3 TYR A 671
LEU A 679
LYS A 678
 None
 0.79A 3sueD-5jcfA:
undetectable		 3sueD-5jcfA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		3 TYR A 405
LEU A 118
LYS A 117
 None
 0.68A 3sueD-5jlcA:
undetectable		 3sueD-5jlcA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		3 TYR S 115
LEU S 139
LYS S 138
 None
 0.77A 3sueD-5k0yS:
undetectable		 3sueD-5k0yS:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 TYR A 216
LEU A 204
LYS A 205
 None
 0.60A 3sueD-5lkdA:
undetectable		 3sueD-5lkdA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mps PRE-MRNA-SPLICING
FACTOR SYF2

(Saccharomyces
cerevisiae) 		no annotation 3 TYR y  97
LEU y 109
LYS y 107
 A  6  91 ( 3.3A)
None
A  6  94 ( 3.3A)
 0.69A 3sueD-5mpsy:
undetectable		 3sueD-5mpsy:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9c OSMOPORIN OMP36

(Klebsiella
aerogenes) 		no annotation 3 TYR C  95
LEU C  81
LYS C  82
 None
 0.78A 3sueD-5o9cC:
undetectable		 3sueD-5o9cC:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 TYR A 583
LEU A  17
LYS A  18
 None
 0.61A 3sueD-5t88A:
undetectable		 3sueD-5t88A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjj TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY

(Alicyclobacillus
acidocaldarius) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		3 TYR A  69
LEU A  17
LYS A  16
 None
 0.56A 3sueD-5tjjA:
undetectable		 3sueD-5tjjA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8e BACILLUS CEREUS
PATB1

(Bacillus cereus) 		no annotation 3 TYR A 158
LEU A 170
LYS A 169
 None
 0.72A 3sueD-5v8eA:
undetectable		 3sueD-5v8eA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn0 16S RRNA
(GUANINE(1405)-N(7))
-METHYLTRANSFERASE

(Proteus
mirabilis) 		no annotation 3 TYR A 249
LEU A 268
LYS A 269
 None
 0.77A 3sueD-6cn0A:
undetectable		 3sueD-6cn0A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf -

(-) 		no annotation 3 TYR 5  33
LEU 5  63
LYS 5  64
 None
 0.77A 3sueD-6cuf5:
undetectable		 3sueD-6cuf5:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fq3 E3 UBIQUITIN-PROTEIN
LIGASE TRIM71

(Danio rerio) 		no annotation 3 TYR A 658
LEU A 682
LYS A 692
 C  B   7 ( 4.5A)
None
None
 0.60A 3sueD-6fq3A:
1.2		 3sueD-6fq3A:
18.56