SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUE_C_SUEC1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		9 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.62A 3sueC-1cu1A:
34.4		 3sueC-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		9 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ASP A 168
 None
 0.90A 3sueC-1cu1A:
34.4		 3sueC-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		9 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 157
 None
 0.74A 3sueC-1cu1A:
34.4		 3sueC-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		9 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
SER A 139
PHE A 154
ASP A 168
 None
 0.99A 3sueC-1cu1A:
34.4		 3sueC-1cu1A:
80.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		5 HIS A 282
ASP A 252
GLY A  82
SER A 155
ALA A 285
 EPE  A 455 (-4.0A)
None
EPE  A 455 (-3.5A)
EPE  A 455 (-1.4A)
None
 1.05A 3sueC-1evqA:
undetectable		 3sueC-1evqA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Escherichia
coli) 		PF00293
(NUDIX) 		5 HIS A  69
GLY A  68
VAL A 117
ALA A  24
ALA A  23
 MN  A1001 (-3.1A)
None
None
None
None
 0.85A 3sueC-1i9aA:
undetectable		 3sueC-1i9aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		5 GLY A 163
VAL A  83
GLY A 261
ALA A 247
ALA A 275
 None
 1.02A 3sueC-1jjiA:
undetectable		 3sueC-1jjiA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		5 ASP A 389
GLY A 283
SER A 387
ALA A 377
ASP A 368
 None
 1.11A 3sueC-1kfwA:
undetectable		 3sueC-1kfwA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		5 GLN H  61
HIS H  57
ASP H 102
GLY H 193
SER H 195
 None
 0.86A 3sueC-1kigH:
8.4		 3sueC-1kigH:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		9 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.72A 3sueC-1ns3A:
30.4		 3sueC-1ns3A:
77.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		6 GLN A  41
HIS A  57
VAL A  78
ASP A  81
GLY A 137
SER A 139
 None
 0.92A 3sueC-1ns3A:
30.4		 3sueC-1ns3A:
77.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
PHE A 154
ALA A 157
ASP A 168
 None
 0.68A 3sueC-1ns3A:
30.4		 3sueC-1ns3A:
77.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		6 HIS A  57
VAL A  78
ASP A  81
GLY A 137
SER A 139
ASP A 168
 None
 1.01A 3sueC-1ns3A:
30.4		 3sueC-1ns3A:
77.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		5 HIS A  47
ASP A  97
GLY A 169
SER A 171
ALA A 188
 None
 0.76A 3sueC-1p3cA:
10.3		 3sueC-1p3cA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3w CYSTEINE DESULFURASE

(Escherichia
coli) 		no annotation 5 GLY B 214
VAL B 250
ALA B  59
ALA B  64
ASP B  60
 None
 1.03A 3sueC-1p3wB:
undetectable		 3sueC-1p3wB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  76
GLY A 104
SER A  93
ALA A  95
ALA A 109
 None
 1.01A 3sueC-1p9hA:
undetectable		 3sueC-1p9hA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  90
GLY A 118
SER A 107
ALA A 109
ALA A 123
 None
 1.01A 3sueC-1p9hA:
undetectable		 3sueC-1p9hA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		5 GLY A  66
ASP A 117
GLY A  62
ALA A 109
ALA A 102
 None
 1.05A 3sueC-1sznA:
undetectable		 3sueC-1sznA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus
coagulans) 		PF00180
(Iso_dh) 		5 HIS A 279
GLY A 295
GLY A  72
ALA A 282
ASP A 284
 None
 1.10A 3sueC-1v5bA:
undetectable		 3sueC-1v5bA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLN A 261
VAL A 176
GLY A 259
ALA A 323
ASP A 366
 None
 1.01A 3sueC-1xkwA:
undetectable		 3sueC-1xkwA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983

(Mycobacterium
tuberculosis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A  49
ASP A  88
GLY A 167
SER A 169
ALA A 186
 None
 0.83A 3sueC-1y8tA:
6.6		 3sueC-1y8tA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 VAL A 352
ASP A 351
GLY A 116
ALA A 109
ALA A 108
 None
 1.00A 3sueC-2c11A:
undetectable		 3sueC-2c11A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fom POLYPROTEIN

(Dengue virus) 		PF00949
(Peptidase_S7) 		5 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
 None
 0.74A 3sueC-2fomB:
10.7		 3sueC-2fomB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp7 GENOME POLYPROTEIN

(West Nile virus) 		PF00949
(Peptidase_S7) 		5 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
 None
 0.96A 3sueC-2fp7B:
12.1		 3sueC-2fp7B:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 GLN A 116
GLY A 513
PHE A 422
ALA A 423
ALA A 424
 None
 1.09A 3sueC-2fqdA:
undetectable		 3sueC-2fqdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		5 GLY A 225
GLY A 267
PHE A 295
ALA A 273
ALA A 274
 PLP  A 400 (-3.5A)
None
None
None
None
 1.00A 3sueC-2isqA:
undetectable		 3sueC-2isqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 GLY A 505
VAL A 513
GLY A 563
ALA A 549
ALA A 548
 4ST  A1687 (-3.2A)
None
None
None
None
 1.10A 3sueC-2j0jA:
undetectable		 3sueC-2j0jA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jet CHYMOTRYPSINOGEN B
CHAIN B
CHYMOTRYPSINOGEN B
CHAIN C

(Rattus
norvegicus) 		PF00089
(Trypsin) 		5 GLY B  19
ASP B  21
GLY B 142
LYS C 154
ASP B  72
 None
 1.11A 3sueC-2jetB:
4.5		 3sueC-2jetB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbe ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		5 GLY A 249
GLY A 217
ALA A 169
ALA A 175
ASP A 239
 None
 0.96A 3sueC-2kbeA:
undetectable		 3sueC-2kbeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 VAL A 351
ASP A 350
GLY A 115
ALA A 108
ALA A 107
 None
 0.97A 3sueC-2pncA:
undetectable		 3sueC-2pncA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		5 GLN A 728
GLY A 727
VAL A 980
GLY A 699
ALA A1109
 None
 1.07A 3sueC-2rhpA:
undetectable		 3sueC-2rhpA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 236
VAL A 239
GLY A 340
SER A 167
ASP A 173
 None
 0.93A 3sueC-2rjtA:
undetectable		 3sueC-2rjtA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 HIS A  39
ASP A  77
GLY A 155
SER A 157
ALA A 174
 None
 0.77A 3sueC-2vidA:
11.8		 3sueC-2vidA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		5 GLY A 214
GLY A 230
LYS A 211
ALA A 209
ALA A 208
 None
 1.10A 3sueC-2vwsA:
undetectable		 3sueC-2vwsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 174
GLY A 403
SER A 401
ALA A 410
ALA A 290
 None
TLM  A1424 (-3.9A)
None
None
None
 1.10A 3sueC-2wgeA:
undetectable		 3sueC-2wgeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 236
GLY A 318
PHE A 230
ALA A 338
ALA A 310
 None
TLM  A1424 ( 4.0A)
None
None
None
 1.05A 3sueC-2wgeA:
undetectable		 3sueC-2wgeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		5 HIS A  51
VAL A  72
ASP A  75
GLY A 133
SER A 135
 None
 0.88A 3sueC-2whxA:
11.2		 3sueC-2whxA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		5 HIS A 435
GLY A 434
VAL A 303
ASP A 304
ALA A 117
 ZN  A1475 ( 3.2A)
None
None
ZN  A1475 ( 2.0A)
None
 1.07A 3sueC-2x98A:
undetectable		 3sueC-2x98A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		5 HIS A 243
GLY A 133
VAL A  48
ASP A  47
GLY A 214
 FE  A 556 (-3.4A)
None
None
MN  A 555 (-3.2A)
None
 0.98A 3sueC-2xmoA:
undetectable		 3sueC-2xmoA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqh IMMUNOGLOBULIN-BINDI
NG PROTEIN EIBD

(Escherichia
coli) 		PF05658
(YadA_head) 		5 GLY A 166
GLY A 194
SER A 183
ALA A 185
ALA A 199
 None
 1.07A 3sueC-2xqhA:
undetectable		 3sueC-2xqhA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 VAL A 458
GLY A 504
SER A 501
ALA A 499
ALA A 426
 None
 1.08A 3sueC-2z0fA:
undetectable		 3sueC-2z0fA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01083
(Cutinase) 		5 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
 None
 1.02A 3sueC-3ajaA:
undetectable		 3sueC-3ajaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 HIS A 125
ASP A 153
GLY A 257
SER A 259
ALA A 281
 None
 0.76A 3sueC-3ak5A:
6.5		 3sueC-3ak5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger) 		PF06441
(EHN) 		5 HIS A 374
ASP A 348
GLY A 116
ALA A 376
ALA A 377
 VPR  A   1 ( 4.6A)
VPR  A   1 ( 4.5A)
None
None
None
 1.11A 3sueC-3g0iA:
undetectable		 3sueC-3g0iA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7n LIPASE

(Penicillium
expansum) 		PF01764
(Lipase_3) 		6 HIS A 241
VAL A 186
ASP A 188
PHE A 162
ALA A 161
ALA A 136
 SO4  A 259 ( 4.6A)
None
None
None
None
None
 1.18A 3sueC-3g7nA:
undetectable		 3sueC-3g7nA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		6 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
 None
 1.42A 3sueC-3gcwA:
undetectable		 3sueC-3gcwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		5 GLY A 194
VAL A 187
GLY A 164
SER A 167
ASP A 287
 None
None
None
SAH  A 350 (-3.1A)
None
 0.90A 3sueC-3gxoA:
undetectable		 3sueC-3gxoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 1.03A 3sueC-3heaA:
undetectable		 3sueC-3heaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kez PUTATIVE SUGAR
BINDING PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 HIS A 418
GLY A 417
VAL A 423
ASP A 422
ALA A 361
 None
 1.10A 3sueC-3kezA:
undetectable		 3sueC-3kezA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ASP A 561
GLY A 425
ALA A 430
ALA A 391
ASP A 433
 None
 1.09A 3sueC-3mosA:
undetectable		 3sueC-3mosA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP

(Staphylococcus
aureus) 		PF00082
(Peptidase_S8) 		5 GLN A 389
HIS A 187
ASP A 140
GLY A 391
SER A 393
 None
 0.89A 3sueC-3qfhA:
undetectable		 3sueC-3qfhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A 173
ASP A 203
GLY A 280
SER A 282
ALA A 299
 None
 0.80A 3sueC-3qo6A:
12.6		 3sueC-3qo6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr3 ENDOGLUCANASE EG-II

(Trichoderma
reesei) 		PF00150
(Cellulase) 		5 GLY A  91
VAL A 141
GLY A  45
PHE A  50
ALA A 294
 None
 0.86A 3sueC-3qr3A:
undetectable		 3sueC-3qr3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.89A 3sueC-3s29A:
undetectable		 3sueC-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 287
GLY A 288
ASP A 417
GLY A 303
ALA A 439
 FRU  A 902 (-4.0A)
None
None
UDP  A 901 ( 2.9A)
FRU  A 902 ( 3.7A)
 1.03A 3sueC-3s29A:
undetectable		 3sueC-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  36
GLY A  64
SER A  53
ALA A  55
ALA A  69
 None
 1.08A 3sueC-3s6lA:
undetectable		 3sueC-3s6lA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  50
GLY A  78
SER A  67
ALA A  69
ALA A  83
 None
 1.05A 3sueC-3s6lA:
undetectable		 3sueC-3s6lA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  92
GLY A 120
SER A 109
ALA A 111
ALA A 125
 None
 1.04A 3sueC-3s6lA:
undetectable		 3sueC-3s6lA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.68A 3sueC-3stjA:
9.3		 3sueC-3stjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1j SERINE PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7) 		5 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
 None
 0.89A 3sueC-3u1jB:
12.7		 3sueC-3u1jB:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE

(Acetobacter
aceti) 		PF02515
(CoA_transf_3) 		5 GLY A  48
VAL A  22
GLY A 408
SER A  75
ALA A 404
 None
COA  A2001 ( 4.9A)
None
None
None
 1.10A 3sueC-3ubmA:
undetectable		 3sueC-3ubmA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufa SERINE PROTEASE SPLA

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.83A 3sueC-3ufaA:
11.4		 3sueC-3ufaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		5 GLY A 140
VAL A 161
GLY A  70
ALA A 119
ALA A 120
 CA0  A 602 ( 4.9A)
None
None
None
None
 0.99A 3sueC-3vexA:
undetectable		 3sueC-3vexA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		5 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
 None
 1.09A 3sueC-3wj2A:
undetectable		 3sueC-3wj2A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 574
GLY A 698
PHE A 669
ALA A 655
ALA A 667
 None
 1.11A 3sueC-3zz1A:
undetectable		 3sueC-3zz1A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 GLY A 241
GLY A 150
SER A 153
PHE A 296
ALA A 300
 None
 1.08A 3sueC-4a01A:
undetectable		 3sueC-4a01A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E

(Linum
nodiflorum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 GLY A 212
VAL A 205
GLY A 181
SER A 183
ASP A 302
 None
None
None
SAH  A 401 (-2.4A)
None
 0.95A 3sueC-4eviA:
undetectable		 3sueC-4eviA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A 159
VAL A 187
ASP A 190
GLY A 266
SER A 268
 None
 0.57A 3sueC-4flnA:
5.0		 3sueC-4flnA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		5 GLY A  18
GLY A 203
ALA A  39
ALA A 211
ASP A  43
 None
 0.99A 3sueC-4go4A:
undetectable		 3sueC-4go4A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A  38
GLY A 272
SER A 752
ALA A 239
ALA A 236
 None
 1.03A 3sueC-4iigA:
undetectable		 3sueC-4iigA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inl SERINE PROTEASE SPLD

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		5 HIS A  39
ASP A  78
GLY A 154
SER A 156
ALA A 173
 None
 0.75A 3sueC-4inlA:
11.8		 3sueC-4inlA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		5 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.74A 3sueC-4mzdA:
undetectable		 3sueC-4mzdA:
17.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		11 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
ASP A 168
 2R8  A 301 ( 3.5A)
2R8  A 301 (-3.3A)
2R8  A 301 (-3.5A)
None
2R8  A 301 (-3.6A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-2.6A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
2R8  A 301 ( 4.5A)
 0.73A 3sueC-4nwkA:
35.1		 3sueC-4nwkA:
98.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nxy ACYL-COA SYNTHETASE

(Streptomyces
lividans) 		PF00583
(Acetyltransf_1) 		5 VAL A  43
ASP A  45
GLY A  96
ALA A  92
ALA A  93
 None
 1.10A 3sueC-4nxyA:
undetectable		 3sueC-4nxyA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		6 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
ALA B 290
 None
 1.41A 3sueC-4ov6B:
undetectable		 3sueC-4ov6B:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 273
GLY A 274
ASP A 404
GLY A 288
ALA A 426
 None
 0.95A 3sueC-4rbnA:
undetectable		 3sueC-4rbnA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.69A 3sueC-4x2xA:
10.4		 3sueC-4x2xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxu FERULIC ACID
ESTERASE AMCE1/FAE1A

(Anaeromyces
mucronatus) 		PF00756
(Esterase) 		5 HIS A 253
ASP A 222
GLY A  64
SER A 156
ASP A 217
 None
 0.64A 3sueC-5cxuA:
undetectable		 3sueC-5cxuA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
 None
 1.04A 3sueC-5cykA:
undetectable		 3sueC-5cykA:
16.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		10 GLN A1041
HIS A1057
GLY A1058
VAL A1078
ASP A1081
GLY A1137
PHE A1154
ALA A1156
ALA A1157
ASP A1168
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.9A)
5RS  A1203 (-3.5A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.0A)
 0.67A 3sueC-5eqqA:
34.3		 3sueC-5eqqA:
93.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 HIS A 550
VAL A 502
GLY A 576
SER A 579
ALA A 398
 None
 1.01A 3sueC-5fjjA:
undetectable		 3sueC-5fjjA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj4 SERINE PROTEASE NS3

(Zika virus) 		PF00949
(Peptidase_S7) 		5 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
 None
 0.92A 3sueC-5gj4B:
12.5		 3sueC-5gj4B:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxj FLAVIVIRUS_NS2B,LINK
ER,PEPTIDASE S7

(Zika virus;
synthetic
construct) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		5 HIS A1051
VAL A1072
ASP A1075
GLY A1133
SER A1135
 None
 0.81A 3sueC-5gxjA:
3.6		 3sueC-5gxjA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idk GENOME
POLYPROTEIN,SERINE
PROTEASE SUBUNIT
NS2B, SERINE
PROTEASE NS3

(West Nile virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		5 HIS A1051
VAL A1072
ASP A1075
GLY A1133
SER A1135
 6A8  A1201 (-3.3A)
None
6A8  A1201 ( 4.2A)
6A8  A1201 (-3.4A)
6A8  A1201 (-1.5A)
 0.98A 3sueC-5idkA:
11.7		 3sueC-5idkA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilb PROTEASE DO-LIKE 2,
CHLOROPLASTIC,PROTEA
SE DO-LIKE 9

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A 159
VAL A 187
ASP A 190
GLY A 266
SER A 268
 None
 0.78A 3sueC-5ilbA:
12.6		 3sueC-5ilbA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7z PUTATIVE SECRETED
ENDOGLYCOSYLCERAMIDA
SE

(Rhodococcus
hoagii) 		PF00150
(Cellulase) 		5 HIS A 125
GLY A 205
VAL A  88
GLY A  46
ALA A 391
 None
 1.09A 3sueC-5j7zA:
undetectable		 3sueC-5j7zA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y 40S RIBOSOMAL
PROTEIN S21

(Oryctolagus
cuniculus) 		no annotation 5 GLY b  25
VAL b  13
GLY b  57
SER b  31
ALA b  54
 None
 0.97A 3sueC-5k0yb:
undetectable		 3sueC-5k0yb:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
 None
 0.94A 3sueC-5kp7A:
undetectable		 3sueC-5kp7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 GLN A1738
GLY A1741
VAL A1573
ALA A1401
ALA A1400
 None
 1.09A 3sueC-5m59A:
undetectable		 3sueC-5m59A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 HIS A 317
ASP A 287
GLY A 117
SER A 190
ALA A 320
 None
 1.06A 3sueC-5mifA:
undetectable		 3sueC-5mifA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 5 HIS A 545
VAL A 497
GLY A 571
SER A 574
ALA A 393
 None
 1.02A 3sueC-5nbsA:
undetectable		 3sueC-5nbsA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora) 		no annotation 5 HIS A 331
ASP A 304
GLY A 150
SER A 217
ALA A 239
 None
 1.01A 3sueC-5no5A:
undetectable		 3sueC-5no5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE

(Zika virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		5 HIS A 116
VAL A 137
ASP A 140
GLY A 198
SER A 200
 None
 0.99A 3sueC-5t1vA:
3.6		 3sueC-5t1vA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		5 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.76A 3sueC-5to3B:
5.8		 3sueC-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
 None
 0.93A 3sueC-5vlhA:
undetectable		 3sueC-5vlhA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
 None
 0.98A 3sueC-5vlhA:
undetectable		 3sueC-5vlhA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vol PUTATIVE ESTERASE

(Bacteroides
intestinalis) 		PF00756
(Esterase) 		5 HIS A 265
ASP A 236
GLY A  65
SER A 152
ASP A 231
 None
 0.85A 3sueC-5volA:
undetectable		 3sueC-5volA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 7 GLN A  41
GLY A  58
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.67A 3sueC-5wdxA:
27.0		 3sueC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 9 HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
ASP A 168
 None
 0.69A 3sueC-5wdxA:
27.0		 3sueC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 5 HIS X 578
GLY X 580
VAL X 444
ALA X 617
ALA X 618
 None
 1.09A 3sueC-6elqX:
undetectable		 3sueC-6elqX:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dus MJ0882

(Methanocaldococcus
jannaschii) 		PF05175
(MTS) 		4 TYR A  37
ILE A  46
LEU A  47
LYS A  45
 None
 1.13A 3sueC-1dusA:
undetectable		 3sueC-1dusA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvz KALLIKREIN-1E2

(Equus caballus) 		PF00089
(Trypsin) 		4 TYR A 137
ILE A 120
LEU A  46
LYS A 119
 None
 1.20A 3sueC-1gvzA:
9.5		 3sueC-1gvzA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2s SENSORY RHODOPSIN II

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin) 		4 TYR A 139
ILE A 156
LEU A 159
LYS A 157
 None
 1.27A 3sueC-1h2sA:
undetectable		 3sueC-1h2sA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2s SENSORY RHODOPSIN II

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin) 		4 TYR A 140
ILE A 156
LEU A 159
LYS A 157
 None
 1.21A 3sueC-1h2sA:
undetectable		 3sueC-1h2sA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		4 PHE A 332
TYR A 375
ILE A 336
LYS A 334
 None
 1.21A 3sueC-1hxjA:
undetectable		 3sueC-1hxjA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		4 PHE A 494
TYR A 491
ILE A 258
LEU A  62
 None
 1.34A 3sueC-1i5pA:
0.0		 3sueC-1i5pA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioo SF11-RNASE

(Nicotiana alata) 		PF00445
(Ribonuclease_T2) 		4 PHE A  29
TYR A 164
LEU A 111
LYS A 112
 None
None
None
NAG  A 197 (-2.9A)
 1.35A 3sueC-1iooA:
undetectable		 3sueC-1iooA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3u ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 PHE A 253
ILE A  46
LEU A  49
LYS A  47
 None
 1.32A 3sueC-1j3uA:
undetectable		 3sueC-1j3uA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		4 PHE P  99
TYR P 129
ILE P  51
LEU P  52
 None
 1.35A 3sueC-1jcmP:
undetectable		 3sueC-1jcmP:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksh ARF-LIKE PROTEIN 2

(Mus musculus) 		PF00025
(Arf) 		4 PHE A  50
TYR A  76
ILE A  88
LEU A  19
 None
 1.27A 3sueC-1kshA:
undetectable		 3sueC-1kshA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 PHE A 139
TYR A 152
ILE A 124
LEU A 109
 None
 1.20A 3sueC-1lf9A:
0.0		 3sueC-1lf9A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlh CONSERVED
HYPOTHETICAL PROTEIN

(Thermoplasma
acidophilum) 		PF04008
(Adenosine_kin) 		4 PHE A  40
TYR A  13
ILE A  79
LEU A  78
 None
 1.36A 3sueC-1rlhA:
undetectable		 3sueC-1rlhA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xea OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Vibrio cholerae) 		PF01408
(GFO_IDH_MocA) 		4 TYR A  56
ILE A  28
LEU A   3
LYS A   4
 None
 1.30A 3sueC-1xeaA:
undetectable		 3sueC-1xeaA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		4 PHE A2418
TYR A2425
ILE A2405
LEU A2411
 None
 1.24A 3sueC-1xktA:
undetectable		 3sueC-1xktA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yj8 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 PHE A 264
TYR A 330
ILE A 145
LYS A 152
 None
 1.18A 3sueC-1yj8A:
undetectable		 3sueC-1yj8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 PHE A 207
TYR A 150
ILE A 283
LEU A 268
 None
 1.22A 3sueC-1z3zA:
undetectable		 3sueC-1z3zA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1f THREONINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		4 PHE A  68
ILE A  42
LEU A  57
LYS A  58
 PLP  A 500 (-4.7A)
None
None
None
 1.23A 3sueC-2d1fA:
undetectable		 3sueC-2d1fA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		4 TYR A 103
ILE A  12
LEU A  15
LYS A  13
 None
 1.21A 3sueC-2greA:
1.9		 3sueC-2greA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		4 TYR A  94
ILE A 193
LEU A 225
LYS A 226
 None
 1.36A 3sueC-2j1nA:
undetectable		 3sueC-2j1nA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz G2/MITOTIC-SPECIFIC
CYCLIN-B1

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 TYR B 371
ILE B 355
LEU B 356
LYS B 354
 None
 1.33A 3sueC-2jgzB:
undetectable		 3sueC-2jgzB:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6x GREEN-LIGHT
ABSORBING
PROTEORHODOPSIN

(uncultured
marine gamma
proteobacterium
EBAC31A08) 		PF01036
(Bac_rhodopsin) 		4 TYR A 204
ILE A 232
LEU A 233
LYS A 231
 None
None
None
RET  A 301 (-1.3A)
 1.11A 3sueC-2l6xA:
undetectable		 3sueC-2l6xA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		4 TYR A 217
ILE A 143
LEU A 146
LYS A 147
 None
 1.05A 3sueC-2o1oA:
undetectable		 3sueC-2o1oA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3a UPF0106 PROTEIN
AF_0751

(Archaeoglobus
fulgidus) 		PF01994
(Trm56) 		4 TYR A  82
ILE A  93
LEU A  90
LYS A  89
 None
 1.24A 3sueC-2o3aA:
undetectable		 3sueC-2o3aA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		4 PHE A 327
ILE A 314
LEU A 317
LYS A 318
 None
 0.86A 3sueC-2o3eA:
undetectable		 3sueC-2o3eA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4o HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		no annotation 4 PHE A 176
TYR A 225
ILE A 206
LEU A 191
 None
 1.34A 3sueC-2p4oA:
undetectable		 3sueC-2p4oA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pxs GFP-LIKE FLUORESCENT
CHROMOPROTEIN FP506

(Zoanthus sp.) 		PF01353
(GFP) 		4 PHE A 181
ILE A 160
LEU A 161
LYS A 162
 None
 1.15A 3sueC-2pxsA:
undetectable		 3sueC-2pxsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqp POLYSIALIC ACID
CAPSULE BIOSYNTHESIS
PROTEIN SIAC

(Neisseria
meningitidis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 PHE A 237
TYR A  45
ILE A 232
LEU A 233
 None
 1.21A 3sueC-2wqpA:
undetectable		 3sueC-2wqpA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3

(Homo sapiens) 		PF00226
(DnaJ)
PF09976
(TPR_21)
PF13181
(TPR_8) 		4 TYR A 262
ILE A 208
LEU A 211
LYS A 212
 None
 1.02A 3sueC-2y4tA:
undetectable		 3sueC-2y4tA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsj THREONINE SYNTHASE

(Aquifex
aeolicus) 		PF00291
(PALP) 		4 PHE A  62
ILE A  34
LEU A  51
LYS A  52
 PLP  A1101 (-4.5A)
None
None
None
 1.15A 3sueC-2zsjA:
undetectable		 3sueC-2zsjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4r PUTATIVE ZINC
METALLOPROTEASE
MJ0392

(Methanocaldococcus
jannaschii) 		PF02163
(Peptidase_M50) 		4 PHE A 202
ILE A 173
LEU A 177
LYS A 175
 None
 1.24A 3sueC-3b4rA:
undetectable		 3sueC-3b4rA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjq PHAGE-RELATED
PROTEIN

(Bordetella
bronchiseptica) 		PF03864
(Phage_cap_E) 		4 TYR A 248
ILE A 209
LEU A 212
LYS A 213
 None
 0.90A 3sueC-3bjqA:
undetectable		 3sueC-3bjqA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 TYR A 167
ILE A 231
LEU A 246
LYS A 242
 None
 1.30A 3sueC-3dqzA:
undetectable		 3sueC-3dqzA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Neisseria
meningitidis) 		PF01048
(PNP_UDP_1) 		4 TYR A  37
ILE A 229
LEU A 233
LYS A 231
 None
 1.30A 3sueC-3eeiA:
undetectable		 3sueC-3eeiA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN

(Homo sapiens) 		PF01536
(SAM_decarbox) 		4 TYR A 158
ILE A  78
LEU A  79
LYS A  80
 None
 1.29A 3sueC-3ep7A:
undetectable		 3sueC-3ep7A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
agalactiae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 PHE A 230
TYR A 209
ILE A  16
LEU A  12
 GOL  A 265 (-3.7A)
None
None
None
 1.35A 3sueC-3eprA:
undetectable		 3sueC-3eprA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		4 PHE A 280
TYR A 271
ILE A 366
LEU A 363
 None
 1.31A 3sueC-3eu8A:
undetectable		 3sueC-3eu8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		4 PHE A  93
TYR A 240
ILE A 273
LEU A 271
 None
NA  A 437 ( 4.6A)
None
None
 1.33A 3sueC-3g0tA:
undetectable		 3sueC-3g0tA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		4 PHE A  35
TYR A  24
ILE A  44
LEU A  43
 None
 1.27A 3sueC-3gveA:
undetectable		 3sueC-3gveA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 PHE A  28
TYR A  14
ILE A  87
LEU A  86
 None
 1.11A 3sueC-3hn2A:
undetectable		 3sueC-3hn2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		4 PHE A 243
TYR A 239
LEU A 258
LYS A 259
 CEW  A 501 (-4.6A)
None
None
CEW  A 501 ( 4.4A)
 1.30A 3sueC-3humA:
undetectable		 3sueC-3humA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig3 PLXNA3 PROTEIN

(Mus musculus) 		PF08337
(Plexin_cytopl) 		4 TYR A1441
ILE A1470
LEU A1469
LYS A1468
 None
 1.07A 3sueC-3ig3A:
undetectable		 3sueC-3ig3A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4n MONOTHIOL
GLUTAREDOXIN-6

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		4 PHE A 220
TYR A 150
ILE A 122
LEU A 125
 None
 1.18A 3sueC-3l4nA:
undetectable		 3sueC-3l4nA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A  89
TYR A 257
ILE A  81
LEU A  84
 None
 1.28A 3sueC-3ozyA:
undetectable		 3sueC-3ozyA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2h BACTERIOFERRITIN

(Pseudomonas
aeruginosa) 		PF00210
(Ferritin) 		4 TYR A 132
ILE A 104
LEU A 119
LYS A 120
 None
 1.19A 3sueC-3r2hA:
undetectable		 3sueC-3r2hA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		4 PHE A 286
TYR A 267
ILE A 112
LEU A  81
 None
 1.12A 3sueC-3rl3A:
undetectable		 3sueC-3rl3A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		4 TYR A1463
ILE A1492
LEU A1491
LYS A1490
 None
 0.93A 3sueC-3rytA:
undetectable		 3sueC-3rytA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tij NUPC FAMILY PROTEIN

(Vibrio cholerae) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		4 TYR A  48
ILE A 199
LEU A 202
LYS A 198
 None
 1.27A 3sueC-3tijA:
undetectable		 3sueC-3tijA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE

(Pachysandra
terminalis) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 PHE A 478
TYR A 435
ILE A 378
LEU A 531
 None
 1.36A 3sueC-3uggA:
0.8		 3sueC-3uggA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A1349
TYR A1606
ILE A1298
LEU A1297
 BTI  A1901 (-4.6A)
None
None
None
 1.36A 3sueC-3va7A:
undetectable		 3sueC-3va7A:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpq GLUTATHIONE
S-TRANSFERASE SIGMA

(Bombyx mori) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 PHE A 128
ILE A 136
LEU A 133
LYS A 132
 None
PGO  A 303 ( 4.3A)
None
PGO  A 309 (-2.7A)
 1.26A 3sueC-3vpqA:
undetectable		 3sueC-3vpqA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
PF17243
(POTRA_TamA_1) 		4 PHE A 429
TYR A 415
LEU A 499
LYS A 498
 None
 1.20A 3sueC-4c00A:
undetectable		 3sueC-4c00A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuv PORIN PROTEIN
ASSOCIATED WITH
IMIPENEM RESISTANCE

(Acinetobacter
baumannii) 		no annotation 4 TYR A  41
ILE A  17
LEU A  16
LYS A  13
 None
C8E  A 308 ( 4.9A)
C8E  A 308 (-4.8A)
None
 1.16A 3sueC-4fuvA:
undetectable		 3sueC-4fuvA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 PHE A 114
TYR A  51
ILE A 198
LEU A 209
 None
 1.18A 3sueC-4gpgA:
10.9		 3sueC-4gpgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1a RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE I

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 PHE A 207
TYR A 200
ILE A 248
LEU A 249
 None
 1.17A 3sueC-4i1aA:
undetectable		 3sueC-4i1aA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9c RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE F

(Bacillus
subtilis) 		PF12895
(ANAPC3)
PF13424
(TPR_12) 		4 PHE A 103
ILE A 132
LEU A 131
LYS A 130
 None
 1.25A 3sueC-4i9cA:
undetectable		 3sueC-4i9cA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 187
TYR A 350
LEU A 192
LYS A 191
 None
 1.15A 3sueC-4it1A:
undetectable		 3sueC-4it1A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j05 PHOSPHATE
TRANSPORTER

(Serendipita
indica) 		PF00083
(Sugar_tr) 		4 PHE A 485
TYR A 328
ILE A 394
LEU A 398
 None
PO4  A 600 (-4.5A)
None
None
 1.24A 3sueC-4j05A:
undetectable		 3sueC-4j05A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 TYR A1018
ILE A 978
LEU A 982
LYS A 980
 None
 1.28A 3sueC-4j3bA:
undetectable		 3sueC-4j3bA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 PHE A 580
TYR A 476
ILE A 538
LEU A 537
 None
 1.04A 3sueC-4jzaA:
undetectable		 3sueC-4jzaA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lzk PIXA INCLUSION BODY
PROTEIN

(Burkholderia
cenocepacia) 		PF12306
(PixA) 		4 PHE A 172
TYR A  27
ILE A  96
LEU A  95
 None
 1.31A 3sueC-4lzkA:
undetectable		 3sueC-4lzkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb5 CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18)
PF16403
(DUF5011) 		4 TYR A 211
ILE A 255
LEU A 254
LYS A 263
 None
 1.18A 3sueC-4mb5A:
undetectable		 3sueC-4mb5A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mea PREDICTED PROTEIN

(Acinetobacter
nosocomialis) 		PF00561
(Abhydrolase_1) 		4 PHE A  87
TYR A 153
ILE A  66
LEU A  73
 None
 0.86A 3sueC-4meaA:
undetectable		 3sueC-4meaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n42 XYLANASE AND
ALPHA-AMYLASE
INHIBITOR PROTEIN
ISOFORM III

(Scadoxus
multiflorus) 		PF00704
(Glyco_hydro_18) 		4 TYR A 256
ILE A 267
LEU A 268
LYS A 266
 None
 1.30A 3sueC-4n42A:
undetectable		 3sueC-4n42A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		4 PHE A 429
TYR A 415
LEU A 499
LYS A 498
 None
 1.23A 3sueC-4n74A:
undetectable		 3sueC-4n74A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsy LYSYL ENDOPEPTIDASE

(Lysobacter
enzymogenes) 		PF13365
(Trypsin_2) 		4 PHE A 114
TYR A  51
ILE A 198
LEU A 209
 None
None
None
2OY  A 301 ( 4.2A)
 1.20A 3sueC-4nsyA:
11.1		 3sueC-4nsyA:
23.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 PHE A  43
TYR A  56
ILE A 132
LEU A 135
 2R8  A 301 (-4.6A)
None
2R8  A 301 (-4.3A)
2R8  A 301 (-4.4A)
 0.54A 3sueC-4nwkA:
35.1		 3sueC-4nwkA:
98.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt9 PUTATIVE
GLUCOAMYLASE

(Bacteroides
caccae) 		PF10091
(Glycoamylase) 		4 PHE A 290
TYR A 281
ILE A 376
LEU A 373
 ACT  A 501 ( 4.9A)
None
None
None
 1.28A 3sueC-4qt9A:
undetectable		 3sueC-4qt9A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 PHE A 206
ILE A  69
LEU A  74
LYS A  68
 None
 1.25A 3sueC-4qtsA:
undetectable		 3sueC-4qtsA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ras OXIDOREDUCTASE,
NAD-BINDING/IRON-SUL
FUR CLUSTER-BINDING
PROTEIN

(Nitratireductor
pacificus) 		PF12838
(Fer4_7)
PF13486
(Dehalogenase) 		4 PHE A 367
ILE A 356
LEU A 359
LYS A 357
 None
 1.34A 3sueC-4rasA:
undetectable		 3sueC-4rasA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4reg UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01905
(DevR) 		4 PHE A  67
ILE A 243
LEU A 242
LYS A 240
 None
 1.37A 3sueC-4regA:
undetectable		 3sueC-4regA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5z CHITINASE 60

(Moritella
marina) 		PF00704
(Glyco_hydro_18) 		4 TYR A 211
ILE A 255
LEU A 254
LYS A 263
 None
 1.21A 3sueC-4w5zA:
undetectable		 3sueC-4w5zA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w82 FATTY ACID SYNTHASE

(Homo sapiens) 		PF00107
(ADH_zinc_N) 		4 PHE A1603
TYR A1567
LEU A1599
LYS A1620
 None
 1.18A 3sueC-4w82A:
undetectable		 3sueC-4w82A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wph UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF12436
(USP7_ICP0_bdg) 		4 PHE A 726
TYR A 692
ILE A 713
LEU A 716
 None
 1.28A 3sueC-4wphA:
undetectable		 3sueC-4wphA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 PHE A 618
ILE A 693
LEU A 649
LYS A 650
 None
 1.30A 3sueC-5a55A:
undetectable		 3sueC-5a55A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcz TANKYRASE-2

(Homo sapiens) 		PF00644
(PARP) 		4 PHE A1098
ILE A 956
LEU A 955
LYS A 999
 None
 1.17A 3sueC-5dczA:
undetectable		 3sueC-5dczA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 PHE A 110
TYR A 404
LEU A  89
LYS A  87
 None
None
EDO  A 505 (-4.4A)
None
 1.02A 3sueC-5e4rA:
undetectable		 3sueC-5e4rA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		4 PHE A 215
TYR A 145
ILE A 115
LEU A 114
 None
 1.24A 3sueC-5ei3A:
0.6		 3sueC-5ei3A:
17.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 PHE A1043
TYR A1056
ILE A1132
LEU A1135
LYS A1136
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
 0.63A 3sueC-5eqqA:
34.3		 3sueC-5eqqA:
93.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1u 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00701
(DHDPS) 		4 TYR A 196
ILE A 246
LEU A 247
LYS A 245
 None
 1.30A 3sueC-5f1uA:
undetectable		 3sueC-5f1uA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 PHE A 551
TYR A 297
ILE A 624
LEU A 621
 None
 1.28A 3sueC-5gl7A:
undetectable		 3sueC-5gl7A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5b THYMIDYLATE KINASE

(Aquifex
aeolicus) 		no annotation 4 PHE B  91
TYR B  34
ILE B 172
LEU B 128
 None
 1.14A 3sueC-5h5bB:
undetectable		 3sueC-5h5bB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A1349
TYR A1606
ILE A1298
LEU A1297
 None
 1.34A 3sueC-5i8iA:
undetectable		 3sueC-5i8iA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3r MONOTHIOL
GLUTAREDOXIN-6

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		4 PHE A 220
TYR A 150
ILE A 122
LEU A 125
 None
 1.23A 3sueC-5j3rA:
undetectable		 3sueC-5j3rA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		4 PHE A 726
TYR A 692
ILE A 713
LEU A 716
 None
 1.31A 3sueC-5j7tA:
0.8		 3sueC-5j7tA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL

(Homo sapiens) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 PHE d 228
TYR d 178
ILE d 276
LEU d 277
 None
 1.00A 3sueC-5oold:
undetectable		 3sueC-5oold:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A 441
ILE A 315
LEU A 386
LYS A 383
 None
 1.32A 3sueC-5tqwA:
undetectable		 3sueC-5tqwA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tum TETRACYCLINE
DESTRUCTASE TET(56)

(Legionella
longbeachae) 		PF01494
(FAD_binding_3) 		4 PHE A  28
TYR A 323
ILE A  33
LEU A  32
 None
 1.12A 3sueC-5tumA:
undetectable		 3sueC-5tumA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ty7 PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		no annotation 4 PHE A 243
TYR A 239
LEU A 258
LYS A 259
 None
None
None
NFF  A 401 ( 4.8A)
 1.23A 3sueC-5ty7A:
undetectable		 3sueC-5ty7A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 PHE A 208
TYR A 215
ILE A 353
LEU A 352
 None
 1.19A 3sueC-5u09A:
undetectable		 3sueC-5u09A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8d BACILLUS CEREUS
PATB1

(Bacillus cereus) 		no annotation 4 TYR C 165
ILE C 177
LEU C 179
LYS C 178
 None
 1.11A 3sueC-5v8dC:
undetectable		 3sueC-5v8dC:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8e BACILLUS CEREUS
PATB1

(Bacillus cereus) 		no annotation 4 TYR A 165
ILE A 177
LEU A 179
LYS A 178
 None
 1.14A 3sueC-5v8eA:
undetectable		 3sueC-5v8eA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 4 PHE A  43
TYR A  56
ILE A 132
LEU A 135
 None
 0.64A 3sueC-5wdxA:
27.0		 3sueC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		4 PHE A 400
TYR A 406
ILE A 391
LEU A 392
 None
 0.94A 3sueC-5xhqA:
undetectable		 3sueC-5xhqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 4 PHE A 319
TYR A 286
ILE A  87
LEU A  28
 None
 1.19A 3sueC-5xmdA:
undetectable		 3sueC-5xmdA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqh PROTEIN ROGDI
HOMOLOG

(Homo sapiens) 		PF10259
(Rogdi_lz) 		4 PHE A 100
ILE A  62
LEU A  63
LYS A  72
 None
 1.19A 3sueC-5xqhA:
undetectable		 3sueC-5xqhA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		no annotation 4 PHE A 107
TYR A 230
ILE A  57
LEU A  84
 None
 1.25A 3sueC-5yt0A:
1.8		 3sueC-5yt0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azh TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Clostridium
perfringens) 		no annotation 4 TYR A  92
ILE A  69
LEU A  66
LYS A  65
 None
 1.01A 3sueC-6azhA:
undetectable		 3sueC-6azhA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 TYR A1048
ILE A1077
LEU A1080
LYS A1078
 None
 1.10A 3sueC-6b3rA:
undetectable		 3sueC-6b3rA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 4 TYR A 160
ILE A 132
LEU A 135
LYS A 133
 None
 1.16A 3sueC-6ei3A:
undetectable		 3sueC-6ei3A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fj4 ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		no annotation 4 TYR A1049
ILE A 998
LEU A1003
LYS A1005
 None
 1.30A 3sueC-6fj4A:
undetectable		 3sueC-6fj4A:
16.24