SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUE_B_SUEB1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ap2 MONOCLONAL ANTIBODY
C219

(Mus musculus) 		PF07686
(V-set) 		3 PHE A  77
TYR A  98
LEU A  53
 None
 0.79A 3sueB-1ap2A:
undetectable		 3sueB-1ap2A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		3 PHE A  86
TYR A 143
LEU A  70
 None
 0.67A 3sueB-1c4oA:
undetectable		 3sueB-1c4oA:
14.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		3 PHE A  43
TYR A  56
LEU A 135
 None
 0.20A 3sueB-1cu1A:
34.8		 3sueB-1cu1A:
80.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6l ANTI-FERRITIN
IMMUNOGLOBULIN LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 PHE L  71
TYR L  92
LEU L  47
 None
 0.76A 3sueB-1f6lL:
0.0		 3sueB-1f6lL:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		3 PHE A 272
TYR A 166
LEU A 276
 None
 0.76A 3sueB-1fn9A:
0.0		 3sueB-1fn9A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnz BARK AGGLUTININ I,
POLYPEPTIDE A

(Robinia
pseudoacacia) 		PF00139
(Lectin_legB) 		3 PHE A 210
TYR A  52
LEU A  47
 None
 0.76A 3sueB-1fnzA:
0.0		 3sueB-1fnzA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7y STEM/LEAF LECTIN
DB58

(Vigna
unguiculata) 		PF00139
(Lectin_legB) 		3 PHE A 208
TYR A  50
LEU A  45
 None
 0.79A 3sueB-1g7yA:
0.0		 3sueB-1g7yA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkh GAMMA LACTAMASE

(Microbacterium) 		PF00561
(Abhydrolase_1) 		3 PHE A  97
TYR A  32
LEU A  94
 None
 0.75A 3sueB-1hkhA:
0.0		 3sueB-1hkhA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i60 IOLI PROTEIN

(Bacillus
subtilis) 		PF01261
(AP_endonuc_2) 		3 PHE A 143
TYR A 158
LEU A 106
 None
 0.77A 3sueB-1i60A:
undetectable		 3sueB-1i60A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN

(Mus musculus) 		PF02816
(Alpha_kinase) 		3 PHE A1686
TYR A1696
LEU A1593
 None
 0.75A 3sueB-1iahA:
undetectable		 3sueB-1iahA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js4 ENDO/EXOCELLULASE E4

(Thermobifida
fusca) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		3 PHE A   4
TYR A 352
LEU A  10
 None
 0.62A 3sueB-1js4A:
undetectable		 3sueB-1js4A:
17.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 PHE A  43
TYR A  56
LEU A 135
 None
 0.40A 3sueB-1ns3A:
30.6		 3sueB-1ns3A:
77.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ntg TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF01588
(tRNA_bind) 		3 PHE A 152
TYR A 114
LEU A 156
 None
 0.79A 3sueB-1ntgA:
undetectable		 3sueB-1ntgA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 PHE A1316
TYR A1332
LEU A1284
 None
 0.68A 3sueB-1ofeA:
undetectable		 3sueB-1ofeA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 PHE A 829
TYR A 769
LEU A 834
 None
 0.70A 3sueB-1qgrA:
undetectable		 3sueB-1qgrA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r75 HYPOTHETICAL PROTEIN

(Leishmania
major) 		PF09149
(DUF1935) 		3 PHE A  47
TYR A  27
LEU A 102
 None
 0.54A 3sueB-1r75A:
undetectable		 3sueB-1r75A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1viw ALPHA-AMYLASE-INHIBI
TOR

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		3 PHE B 105
TYR B 186
LEU B  82
 None
 0.68A 3sueB-1viwB:
undetectable		 3sueB-1viwB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkz PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Thermotoga
maritima) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		3 PHE A 257
TYR A 302
LEU A  91
 None
 0.77A 3sueB-1vkzA:
undetectable		 3sueB-1vkzA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwm HYPOTHETICAL PROTEIN
TT2028

(Thermus
thermophilus) 		no annotation 3 PHE A 115
TYR A  46
LEU A 106
 None
 0.77A 3sueB-1wwmA:
undetectable		 3sueB-1wwmA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzx COG3291: FOG: PKD
REPEAT

(Ruminiclostridium
thermocellum) 		no annotation 3 PHE A  89
TYR A  86
LEU A  48
 None
 0.79A 3sueB-1wzxA:
undetectable		 3sueB-1wzxA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		3 PHE A 598
TYR A 515
LEU A 529
 None
 0.53A 3sueB-1xdpA:
undetectable		 3sueB-1xdpA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv5 DNA
ALPHA-GLUCOSYLTRANSF
ERASE

(Escherichia
virus T4) 		PF11440
(AGT) 		3 PHE A1146
TYR A1112
LEU A1119
 None
 0.79A 3sueB-1xv5A:
undetectable		 3sueB-1xv5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		3 PHE A 302
TYR A 305
LEU A 292
 None
 0.80A 3sueB-1yp4A:
undetectable		 3sueB-1yp4A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7a CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF01522
(Polysacc_deac_1) 		3 PHE A 287
TYR A 278
LEU A  33
 None
 0.74A 3sueB-1z7aA:
undetectable		 3sueB-1z7aA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2f EXOCYST COMPLEX
COMPONENT SEC15

(Drosophila
melanogaster) 		PF04091
(Sec15) 		3 PHE X 288
TYR X 227
LEU X 280
 None
 0.79A 3sueB-2a2fX:
undetectable		 3sueB-2a2fX:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		3 PHE A 123
TYR A  87
LEU A 129
 None
MES  A2403 (-4.7A)
None
 0.74A 3sueB-2b81A:
undetectable		 3sueB-2b81A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 PHE A 374
TYR A 402
LEU A 353
 None
 0.71A 3sueB-2csdA:
undetectable		 3sueB-2csdA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuh TENASCIN-X

(Homo sapiens) 		PF00041
(fn3) 		3 PHE A  23
TYR A  61
LEU A  96
 None
 0.60A 3sueB-2cuhA:
undetectable		 3sueB-2cuhA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		3 PHE A 134
TYR A 490
LEU A 187
 None
 0.77A 3sueB-2d4eA:
undetectable		 3sueB-2d4eA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gai DNA TOPOISOMERASE I

(Thermotoga
maritima) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 PHE A 510
TYR A 502
LEU A 457
 None
 0.76A 3sueB-2gaiA:
undetectable		 3sueB-2gaiA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk3 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07090
(GATase1_like) 		3 PHE A 220
TYR A 186
LEU A 118
 None
 0.76A 3sueB-2gk3A:
undetectable		 3sueB-2gk3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		3 PHE A  93
TYR A 105
LEU A 158
 None
 0.78A 3sueB-2i5gA:
undetectable		 3sueB-2i5gA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 4

(Homo sapiens) 		PF04099
(Sybindin) 		3 PHE D 119
TYR D 147
LEU D 111
 None
 0.56A 3sueB-2j3tD:
undetectable		 3sueB-2j3tD:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j63 AP-ENDONUCLEASE

(Leishmania
major) 		PF03372
(Exo_endo_phos) 		3 PHE A 440
TYR A 392
LEU A 165
 None
 0.73A 3sueB-2j63A:
undetectable		 3sueB-2j63A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		3 PHE X 299
TYR X  12
LEU X 104
 None
 0.74A 3sueB-2odtX:
undetectable		 3sueB-2odtX:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		3 PHE A 156
TYR A  68
LEU A  55
 None
 0.77A 3sueB-2oq2A:
undetectable		 3sueB-2oq2A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056

(Geobacillus
kaustophilus) 		PF08282
(Hydrolase_3) 		3 PHE A 205
TYR A 249
LEU A  15
 None
 0.77A 3sueB-2pq0A:
undetectable		 3sueB-2pq0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8n GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermotoga
maritima) 		PF00342
(PGI) 		3 PHE A 403
TYR A 396
LEU A 252
 None
 0.73A 3sueB-2q8nA:
undetectable		 3sueB-2q8nA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		3 PHE A 829
TYR A 769
LEU A 834
 None
 0.77A 3sueB-2qnaA:
undetectable		 3sueB-2qnaA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 PHE A1279
TYR A1295
LEU A1246
 None
 0.76A 3sueB-2vdcA:
undetectable		 3sueB-2vdcA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnu EXOSOME COMPLEX
EXONUCLEASE RRP44

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 PHE D 829
TYR D 820
LEU D 834
 None
None
A  B  -4 ( 4.4A)
 0.65A 3sueB-2vnuD:
undetectable		 3sueB-2vnuD:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 PHE J 829
TYR J 820
LEU J 834
 None
 0.65A 3sueB-2wp8J:
undetectable		 3sueB-2wp8J:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2u PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		3 PHE A 147
TYR A  36
LEU A 119
 None
 0.72A 3sueB-2x2uA:
undetectable		 3sueB-2x2uA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfg ENDOGLUCANASE 1

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		3 PHE A   4
TYR A 354
LEU A  10
 None
 0.71A 3sueB-2xfgA:
undetectable		 3sueB-2xfgA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		3 PHE A 416
TYR A 535
LEU A 331
 None
 0.71A 3sueB-2ycbA:
undetectable		 3sueB-2ycbA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		3 PHE A 136
TYR A 235
LEU A 146
 None
 0.47A 3sueB-3djcA:
undetectable		 3sueB-3djcA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dur ANTIBODY FV FRAGMENT
SAG173-04

(Mus musculus) 		PF07686
(V-set) 		3 PHE A  71
TYR A  92
LEU A  47
 None
KDO  A 303 (-4.9A)
None
 0.75A 3sueB-3durA:
undetectable		 3sueB-3durA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		3 PHE A  55
TYR A 273
LEU A 207
 None
 0.79A 3sueB-3fdhA:
undetectable		 3sueB-3fdhA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9p PUTATIVE
TRIPHOSPHORIBOSYL-DE
PHOSPHO-COA SYNTHASE

(Archaeoglobus
fulgidus) 		PF01874
(CitG) 		3 PHE A 190
TYR A 206
LEU A 269
 None
 0.71A 3sueB-3h9pA:
undetectable		 3sueB-3h9pA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j26 MINOR VIRION PROTEIN

(Mimivirus-dependent
virus Sputnik) 		no annotation 3 PHE N 103
TYR N 134
LEU N 199
 None
 0.80A 3sueB-3j26N:
undetectable		 3sueB-3j26N:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5j SUPPRESSOR OF FUSED
FAMILY PROTEIN

(Neisseria
gonorrhoeae) 		PF05076
(SUFU) 		3 PHE A 116
TYR A  53
LEU A 120
 None
 0.79A 3sueB-3k5jA:
undetectable		 3sueB-3k5jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		3 PHE A 671
TYR A 349
LEU A 299
 None
 0.77A 3sueB-3la4A:
undetectable		 3sueB-3la4A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE A  71
TYR A  92
LEU A  47
 None
 0.77A 3sueB-3mnzA:
undetectable		 3sueB-3mnzA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		3 PHE A 568
TYR A 599
LEU A 550
 None
 0.79A 3sueB-3nawA:
undetectable		 3sueB-3nawA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntc FAB LIGHT CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE L  71
TYR L  92
LEU L  47
 None
 0.78A 3sueB-3ntcL:
undetectable		 3sueB-3ntcL:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o52 GDP-MANNOSE
PYROPHOSPHATASE NUDK

(Escherichia
coli) 		PF00293
(NUDIX) 		3 PHE A 160
TYR A 183
LEU A 156
 None
NA  A7113 (-3.9A)
None
 0.78A 3sueB-3o52A:
undetectable		 3sueB-3o52A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc7 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		3 PHE A 120
TYR A 167
LEU A 153
 None
 0.61A 3sueB-3oc7A:
undetectable		 3sueB-3oc7A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 PHE A 286
TYR A 267
LEU A  81
 None
 0.53A 3sueB-3rl3A:
undetectable		 3sueB-3rl3A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s88 16F6 - HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE H  35
TYR H  59
LEU H  20
 None
 0.71A 3sueB-3s88H:
undetectable		 3sueB-3s88H:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		3 PHE A 390
TYR A 246
LEU A  11
 None
 0.74A 3sueB-3sdoA:
undetectable		 3sueB-3sdoA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td7 FAD-LINKED
SULFHYDRYL OXIDASE
R596

(Acanthamoeba
polyphaga
mimivirus) 		PF04777
(Evr1_Alr) 		3 PHE A 165
TYR A 172
LEU A 160
 None
 0.73A 3sueB-3td7A:
undetectable		 3sueB-3td7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqc PANTOTHENATE KINASE

(Coxiella
burnetii) 		PF00485
(PRK) 		3 PHE A 229
TYR A 294
LEU A 315
 None
 0.79A 3sueB-3tqcA:
undetectable		 3sueB-3tqcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4j NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		3 PHE A  90
TYR A 131
LEU A 208
 None
 0.66A 3sueB-3u4jA:
undetectable		 3sueB-3u4jA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Mus musculus) 		PF00079
(Serpin) 		3 PHE A  67
TYR A 408
LEU A 111
 None
 0.75A 3sueB-4ajtA:
undetectable		 3sueB-4ajtA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4big UNCHARACTERIZED
LIPOPROTEIN
SAOUHSC_00053

(Staphylococcus
aureus) 		PF04507
(DUF576) 		3 PHE A 232
TYR A 186
LEU A 235
 None
 0.62A 3sueB-4bigA:
undetectable		 3sueB-4bigA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		3 PHE A  26
TYR A 374
LEU A  32
 None
 0.69A 3sueB-4doeA:
undetectable		 3sueB-4doeA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA

(Rhodococcus
rhodochrous) 		PF00067
(p450) 		3 PHE A 464
TYR A 201
LEU A 439
 None
 0.71A 3sueB-4ep6A:
undetectable		 3sueB-4ep6A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f48 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF00563
(EAL) 		3 PHE A  42
TYR A  39
LEU A  45
 C2E  A 501 (-3.6A)
None
None
 0.79A 3sueB-4f48A:
undetectable		 3sueB-4f48A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 PHE A 374
TYR A 402
LEU A 353
 None
 0.64A 3sueB-4gfjA:
undetectable		 3sueB-4gfjA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 11
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17

(Schizosaccharomyces
pombe) 		PF10156
(Med17)
no annotation 		3 PHE Q 397
TYR K  95
LEU Q 473
 None
 0.80A 3sueB-4h63Q:
undetectable		 3sueB-4h63Q:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbc ANTIGEN BINDING
FRAGMENT,
IMMUNOGLOBULIN IGG -
LIGHT CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PHE L  71
TYR L  92
LEU L  47
 None
 0.78A 3sueB-4hbcL:
undetectable		 3sueB-4hbcL:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		no annotation 3 PHE C  96
TYR C 231
LEU C  45
 None
 0.69A 3sueB-4kd5C:
undetectable		 3sueB-4kd5C:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0k DRAIII

(Deinococcus
radiophilus) 		no annotation 3 PHE A 196
TYR A 127
LEU A 162
 None
 0.79A 3sueB-4l0kA:
undetectable		 3sueB-4l0kA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9m RAS GUANYL-RELEASING
PROTEIN 1

(Homo sapiens) 		PF00130
(C1_1)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF13405
(EF-hand_6) 		3 PHE A 479
TYR A 489
LEU A 412
 None
 0.80A 3sueB-4l9mA:
undetectable		 3sueB-4l9mA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR

(Parabacteroides
distasonis) 		PF04773
(FecR)
PF16344
(DUF4974) 		3 PHE A 175
TYR A 156
LEU A 197
 None
 0.65A 3sueB-4m0hA:
undetectable		 3sueB-4m0hA:
20.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 PHE A  43
TYR A  56
LEU A 135
 2R8  A 301 (-4.6A)
None
2R8  A 301 (-4.4A)
 0.31A 3sueB-4nwkA:
34.6		 3sueB-4nwkA:
98.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p79 CLAUDIN-15

(Mus musculus) 		PF00822
(PMP22_Claudin) 		3 PHE A  45
TYR A  50
LEU A 158
 None
OLC  A 201 (-4.3A)
None
 0.65A 3sueB-4p79A:
undetectable		 3sueB-4p79A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		3 PHE A 688
TYR A 695
LEU A 658
 None
 0.75A 3sueB-4pkvA:
undetectable		 3sueB-4pkvA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		3 PHE A  34
TYR A  41
LEU A  65
 None
 0.73A 3sueB-4qtsA:
undetectable		 3sueB-4qtsA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		3 PHE A1673
TYR A1705
LEU A1698
 None
 0.80A 3sueB-4r04A:
undetectable		 3sueB-4r04A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1j GU4 NUCLEIC-BINDING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF01588
(tRNA_bind) 		3 PHE A 165
TYR A  61
LEU A 140
 None
 0.75A 3sueB-4r1jA:
undetectable		 3sueB-4r1jA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u36 SEED LECTIN

(Vatairea
macrocarpa) 		PF00139
(Lectin_legB) 		3 PHE A 207
TYR A  52
LEU A  47
 None
 0.79A 3sueB-4u36A:
undetectable		 3sueB-4u36A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF00028
(Cadherin) 		3 PHE A 147
TYR A  36
LEU A 119
 None
 0.74A 3sueB-4ux8A:
undetectable		 3sueB-4ux8A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4y HUMAN VARIABLE LIGHT
CHAIN OF HERCEPTIN

(Homo sapiens) 		PF07686
(V-set) 		3 PHE B  71
TYR B  92
LEU B  47
 None
 0.73A 3sueB-4x4yB:
undetectable		 3sueB-4x4yB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn2 FUSOLIN

(unidentified
entomopoxvirus) 		PF03067
(LPMO_10) 		3 PHE A 136
TYR A 223
LEU A 132
 None
 0.74A 3sueB-4yn2A:
undetectable		 3sueB-4yn2A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3k UNCHARACTERIZED
PROTEIN PA3435

(Pseudomonas
aeruginosa) 		PF00258
(Flavodoxin_1) 		3 PHE A 100
TYR A  96
LEU A 123
 None
 0.73A 3sueB-5b3kA:
undetectable		 3sueB-5b3kA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjb OSTEOCLAST-ASSOCIATE
D
IMMUNOGLOBULIN-LIKE
RECEPTOR

(Homo sapiens) 		PF13895
(Ig_2) 		3 PHE A  69
TYR A 106
LEU A 125
 None
 0.76A 3sueB-5cjbA:
undetectable		 3sueB-5cjbA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e59 FRNE PROTEIN

(Deinococcus
radiodurans) 		PF01323
(DSBA) 		3 PHE A 110
TYR A 178
LEU A  54
 None
 0.59A 3sueB-5e59A:
undetectable		 3sueB-5e59A:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		3 PHE A1043
TYR A1056
LEU A1135
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
 0.11A 3sueB-5eqqA:
12.5		 3sueB-5eqqA:
93.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF12341
(Mcl1_mid) 		3 PHE A 584
TYR A 587
LEU A 540
 None
 0.76A 3sueB-5gvbA:
undetectable		 3sueB-5gvbA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gx8 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Streptobacillus
moniliformis) 		PF13416
(SBP_bac_8) 		3 PHE A 404
TYR A 148
LEU A 401
 None
 0.71A 3sueB-5gx8A:
undetectable		 3sueB-5gx8A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 PHE A 374
TYR A 402
LEU A 353
 None
 0.65A 3sueB-5hm5A:
undetectable		 3sueB-5hm5A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imy VAGINOLYSIN

(Gardnerella
vaginalis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 PHE A 210
TYR A 195
LEU A 389
 None
 0.64A 3sueB-5imyA:
undetectable		 3sueB-5imyA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii) 		no annotation 3 PHE A 252
TYR A 206
LEU A  15
 AKG  A 301 (-4.8A)
None
None
 0.68A 3sueB-5j4rA:
undetectable		 3sueB-5j4rA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkp PSEUDOURIDYLATE
SYNTHASE 7

(Homo sapiens) 		PF01142
(TruD) 		3 PHE A 345
TYR A 634
LEU A 623
 None
EDO  A 701 (-4.8A)
None
 0.79A 3sueB-5kkpA:
undetectable		 3sueB-5kkpA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE

(Thermotoga
maritima) 		PF01553
(Acyltransferase) 		3 PHE A  13
TYR A  20
LEU A   8
 None
DD9  A 304 ( 4.7A)
None
 0.67A 3sueB-5kymA:
undetectable		 3sueB-5kymA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113

(Listeria
monocytogenes) 		PF06778
(Chlor_dismutase) 		3 PHE A  17
TYR A  61
LEU A  99
 None
 0.72A 3sueB-5loqA:
undetectable		 3sueB-5loqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1q PHAGE TERMINASE
LARGE SUBUNIT

(Thermus phage
G20c) 		PF17289
(Terminase_6C) 		3 PHE A 304
TYR A 301
LEU A 307
 None
 0.70A 3sueB-5m1qA:
undetectable		 3sueB-5m1qA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 3 PHE A  55
TYR A  88
LEU A  36
 GOL  A 403 (-3.4A)
None
None
 0.50A 3sueB-5m86A:
undetectable		 3sueB-5m86A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mps PRE-MRNA-PROCESSING
FACTOR 17

(Saccharomyces
cerevisiae) 		PF00249
(Myb_DNA-binding) 		3 PHE o 302
TYR o 350
LEU o 299
 None
C  I  59 ( 4.7A)
None
 0.65A 3sueB-5mpso:
undetectable		 3sueB-5mpso:
18.63