SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUE_A_SUEA1201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8q BROMOPEROXIDASE A1

(Kitasatospora
aureofaciens)
PF00561
(Abhydrolase_1)
5 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
None
0.95A 3sueA-1a8qA:
undetectable
3sueA-1a8qA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE


(Escherichia
coli)
PF13561
(adh_short_C2)
5 GLY A  87
ASP A  90
ILE A  55
ALA A  36
ALA A  32
None
1.02A 3sueA-1ahiA:
undetectable
3sueA-1ahiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus)
PF00285
(Citrate_synt)
5 GLY A 283
ILE A 332
GLY A 316
PHE A 275
ALA A 181
None
1.00A 3sueA-1aj8A:
undetectable
3sueA-1aj8A:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)


(Hepacivirus C)
PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD)
9 GLN A  41
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
None
0.66A 3sueA-1cu1A:
34.8
3sueA-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)


(Hepacivirus C)
PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD)
8 HIS A  57
GLY A  58
ASP A  81
LYS A 136
GLY A 137
SER A 139
ALA A 156
ALA A 157
None
0.69A 3sueA-1cu1A:
34.8
3sueA-1cu1A:
80.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE


(Moorella
thermoacetica)
PF01268
(FTHFS)
5 HIS A1280
GLY A1281
ILE A1286
GLY A1272
ALA A1212
None
1.07A 3sueA-1eg7A:
undetectable
3sueA-1eg7A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elv COMPLEMENT C1S
COMPONENT


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 HIS A 460
ASP A 514
LYS A 614
GLY A 615
SER A 617
SO4  A2001 ( 3.9A)
None
SO4  A2001 (-2.9A)
SO4  A2001 (-4.1A)
SO4  A2001 ( 2.7A)
0.83A 3sueA-1elvA:
11.3
3sueA-1elvA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep5 CAPSID PROTEIN C

(Venezuelan
equine
encephalitis
virus)
no annotation 5 HIS B 152
ASP B 174
LYS B 223
GLY B 224
SER B 226
None
1.01A 3sueA-1ep5B:
10.9
3sueA-1ep5B:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius)
PF07859
(Abhydrolase_3)
5 HIS A 282
ASP A 252
GLY A  82
SER A 155
ALA A 285
EPE  A 455 (-4.0A)
None
EPE  A 455 (-3.5A)
EPE  A 455 (-1.4A)
None
0.99A 3sueA-1evqA:
undetectable
3sueA-1evqA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE


(Aspergillus
japonicus)
no annotation 5 GLY A 329
ILE A 287
PHE A 276
ALA A 275
ALA A 301
None
1.04A 3sueA-1juhA:
undetectable
3sueA-1juhA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20)
PF00704
(Glyco_hydro_18)
5 GLY A 195
ILE A  58
GLY A 204
ALA A 146
ALA A 145
None
0.88A 3sueA-1kfwA:
undetectable
3sueA-1kfwA:
17.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
5 GLN A  41
HIS A  57
ASP A  81
GLY A 137
SER A 139
None
0.95A 3sueA-1ns3A:
30.8
3sueA-1ns3A:
77.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
8 GLN A  41
HIS A  57
GLY A  58
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
None
0.69A 3sueA-1ns3A:
30.8
3sueA-1ns3A:
77.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE


(Bacillus
intermedius)
PF00089
(Trypsin)
5 HIS A  47
ASP A  97
GLY A 169
SER A 171
ALA A 188
None
0.74A 3sueA-1p3cA:
10.6
3sueA-1p3cA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica)
PF05658
(YadA_head)
PF05662
(YadA_stalk)
5 GLY A  76
GLY A 104
SER A  93
ALA A  95
ALA A 109
None
1.08A 3sueA-1p9hA:
undetectable
3sueA-1p9hA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica)
PF05658
(YadA_head)
PF05662
(YadA_stalk)
5 GLY A  90
GLY A 118
SER A 107
ALA A 109
ALA A 123
None
1.08A 3sueA-1p9hA:
undetectable
3sueA-1p9hA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica)
PF05658
(YadA_head)
PF05662
(YadA_stalk)
5 GLY A 131
ILE A 171
GLY A 158
SER A 147
ALA A 149
None
0.90A 3sueA-1p9hA:
undetectable
3sueA-1p9hA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE


(Saccharomyces
cerevisiae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 GLN A 160
GLY A  66
ILE A  85
ALA A  58
ALA A  55
None
1.02A 3sueA-1pvdA:
undetectable
3sueA-1pvdA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgf NERVE GROWTH FACTOR

(Mus musculus)
PF00089
(Trypsin)
5 HIS G  57
ASP G 102
LYS G 192
GLY G 193
SER G 195
None
0.79A 3sueA-1sgfG:
10.3
3sueA-1sgfG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei)
PF16499
(Melibiase_2)
5 GLY A  66
ASP A 117
GLY A  62
ALA A 109
ALA A 102
None
1.02A 3sueA-1sznA:
undetectable
3sueA-1sznA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN


(Pyrococcus
horikoshii)
PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C)
5 ASP A  65
ILE A 101
GLY A 109
ALA A  98
ALA A  99
None
1.06A 3sueA-1uz5A:
undetectable
3sueA-1uz5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE


(Thermus
thermophilus)
PF02570
(CbiC)
5 GLY A 208
ILE A 181
GLY A  59
ALA A 199
ALA A 196
None
1.01A 3sueA-1v9cA:
undetectable
3sueA-1v9cA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1


(Pyrococcus
furiosus)
PF00291
(PALP)
5 GLN B 109
GLY B 298
ILE B 341
GLY B 372
ALA B 347
PLP  B 400 (-3.4A)
PLP  B 400 (-3.8A)
None
PLP  B 400 (-3.4A)
None
1.02A 3sueA-1wdwB:
undetectable
3sueA-1wdwB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983


(Mycobacterium
tuberculosis)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 HIS A  49
ASP A  88
GLY A 167
SER A 169
ALA A 186
None
0.83A 3sueA-1y8tA:
12.7
3sueA-1y8tA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT


(Homo sapiens)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 GLN A 483
ILE A 424
GLY A 479
ALA A 463
ALA A 453
None
1.02A 3sueA-1z68A:
undetectable
3sueA-1z68A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxx 6-PHOSPHOFRUCTOKINAS
E


(Lactobacillus
delbrueckii)
PF00365
(PFK)
5 GLY A 254
ILE A 100
GLY A 138
ALA A  18
ALA A  19
None
0.99A 3sueA-1zxxA:
undetectable
3sueA-1zxxA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon)
PF07859
(Abhydrolase_3)
5 HIS A 281
ASP A 251
ILE A  95
GLY A  81
SER A 154
None
0.93A 3sueA-2c7bA:
undetectable
3sueA-2c7bA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea3 CHYMOTRYPSIN

(Cellulomonas
bogoriensis)
PF00089
(Trypsin)
5 GLN A 167
ILE A 108
GLY A 149
ALA A  87
ALA A  88
None
0.99A 3sueA-2ea3A:
11.9
3sueA-2ea3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvk HEME PEROXIDASE

(Bacteroides
thetaiotaomicron)
PF04261
(Dyp_perox)
5 GLY A  18
ILE A  25
SER A  65
PHE A  64
ALA A 114
None
1.06A 3sueA-2gvkA:
undetectable
3sueA-2gvkA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana)
PF00291
(PALP)
5 GLY A 225
GLY A 267
PHE A 295
ALA A 273
ALA A 274
PLP  A 400 (-3.5A)
None
None
None
None
0.94A 3sueA-2isqA:
undetectable
3sueA-2isqA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I


(Escherichia
coli)
PF00365
(PFK)
5 GLY A 254
ILE A 100
GLY A 138
ALA A  18
ALA A  19
None
1.02A 3sueA-2pfkA:
undetectable
3sueA-2pfkA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE


(Escherichia
virus N4)
no annotation 5 GLY A  50
ILE A 214
GLY A 219
SER A  46
ALA A 158
None
0.95A 3sueA-2po4A:
undetectable
3sueA-2po4A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B
CYTOCHROME C1


(Rhodobacter
sphaeroides)
PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02167
(Cytochrom_C1)
5 ASP A 278
ILE B 131
GLY B 109
ALA B 106
ALA B 104
None
HEM  B 301 ( 4.3A)
None
None
None
0.86A 3sueA-2qjpA:
undetectable
3sueA-2qjpA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvd 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Bacillus
anthracis)
PF13561
(adh_short_C2)
5 GLY A  81
ASP A  84
ILE A  49
ALA A  29
ALA A  25
None
1.02A 3sueA-2uvdA:
undetectable
3sueA-2uvdA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus)
PF00089
(Trypsin)
5 HIS A  39
ASP A  77
GLY A 155
SER A 157
ALA A 174
None
0.77A 3sueA-2vidA:
12.1
3sueA-2vidA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE


(Kluyveromyces
lactis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 GLN A 160
GLY A  66
ILE A  85
ALA A  58
ALA A  55
None
1.05A 3sueA-2vk4A:
undetectable
3sueA-2vk4A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 236
GLY A 318
PHE A 230
ALA A 338
ALA A 310
None
TLM  A1424 ( 4.0A)
None
None
None
1.06A 3sueA-2wgeA:
undetectable
3sueA-2wgeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea)
PF16499
(Melibiase_2)
5 GLY A 271
ILE A  83
GLY A  12
ALA A  31
ALA A  32
None
0.99A 3sueA-3a5vA:
undetectable
3sueA-3a5vA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE


(Bifidobacterium
longum)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
5 GLN A 606
GLY A 604
ILE A 655
ALA A 647
ALA A 646
None
1.05A 3sueA-3ai7A:
undetectable
3sueA-3ai7A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN


(Mycolicibacterium
smegmatis)
PF01083
(Cutinase)
5 HIS A 300
GLY A 293
ASP A 269
GLY A  83
SER A 176
None
0.98A 3sueA-3ajaA:
undetectable
3sueA-3ajaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP


(Escherichia
coli)
PF02395
(Peptidase_S6)
5 HIS A 125
ASP A 153
GLY A 257
SER A 259
ALA A 281
None
0.76A 3sueA-3ak5A:
6.8
3sueA-3ak5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw2 2-NITROPROPANE
DIOXYGENASE


(Streptomyces
ansochromogenes)
PF03060
(NMO)
5 GLY A 195
ILE A 223
GLY A 216
ALA A 213
ALA A 234
None
None
FMN  A 370 (-3.3A)
None
None
1.08A 3sueA-3bw2A:
undetectable
3sueA-3bw2A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3p METHYLTRANSFERASE

(Geobacter
sulfurreducens)
PF01596
(Methyltransf_3)
5 GLY A 164
ASP A 132
ILE A 195
GLY A 199
ALA A 157
None
1.01A 3sueA-3c3pA:
undetectable
3sueA-3c3pA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6s PUTATIVE
ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
FAMILY PROTEIN


(Bacteroides
vulgatus)
PF03372
(Exo_endo_phos)
5 GLN A  45
GLY A 171
ILE A  65
ALA A 134
ALA A 121
None
1.02A 3sueA-3g6sA:
undetectable
3sueA-3g6sA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
6 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
None
1.40A 3sueA-3gcwA:
undetectable
3sueA-3gcwA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens)
PF00561
(Abhydrolase_1)
5 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
0.96A 3sueA-3heaA:
undetectable
3sueA-3heaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js4 SUPEROXIDE DISMUTASE

(Anaplasma
phagocytophilum)
PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C)
5 ASP A 150
ILE A  56
GLY A  67
ALA A  75
ALA A  74
None
1.06A 3sueA-3js4A:
undetectable
3sueA-3js4A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxq TRIOSEPHOSPHATE
ISOMERASE


(Bartonella
henselae)
PF00121
(TIM)
5 GLN A  68
ILE A  63
GLY A  11
SER A 238
LYS A 240
None
None
None
None
EDO  A 302 (-3.1A)
1.04A 3sueA-3kxqA:
undetectable
3sueA-3kxqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfh EPIDERMIN LEADER
PEPTIDE PROCESSING
SERINE PROTEASE EPIP


(Staphylococcus
aureus)
PF00082
(Peptidase_S8)
5 GLN A 389
HIS A 187
ASP A 140
GLY A 391
SER A 393
None
0.87A 3sueA-3qfhA:
undetectable
3sueA-3qfhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 HIS A 173
ASP A 203
GLY A 280
SER A 282
ALA A 299
None
0.79A 3sueA-3qo6A:
8.8
3sueA-3qo6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 GLY A 461
ILE A 515
GLY A 547
ALA A 478
ALA A 479
None
0.85A 3sueA-3rimA:
undetectable
3sueA-3rimA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
0.83A 3sueA-3s29A:
undetectable
3sueA-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 HIS A 287
GLY A 288
ASP A 417
GLY A 303
ALA A 439
FRU  A 902 (-4.0A)
None
None
UDP  A 901 ( 2.9A)
FRU  A 902 ( 3.7A)
0.99A 3sueA-3s29A:
undetectable
3sueA-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
None
0.68A 3sueA-3stjA:
9.4
3sueA-3stjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN


(Escherichia
coli)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF)
5 ILE A 350
LYS A 219
GLY A 220
ALA A 331
ALA A 337
None
1.05A 3sueA-3ttfA:
undetectable
3sueA-3ttfA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufa SERINE PROTEASE SPLA

(Staphylococcus
aureus)
PF00089
(Trypsin)
5 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
0.83A 3sueA-3ufaA:
11.8
3sueA-3ufaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2g 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
5 GLY A 108
ASP A 111
ILE A  76
ALA A  56
ALA A  52
None
0.97A 3sueA-3v2gA:
undetectable
3sueA-3v2gA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum)
PF07859
(Abhydrolase_3)
5 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
None
1.04A 3sueA-3wj2A:
undetectable
3sueA-3wj2A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyd LC-EST1C

(uncultured
organism)
PF00326
(Peptidase_S9)
5 HIS A 479
ASP A 447
GLY A 327
SER A 399
ALA A 483
None
0.94A 3sueA-3wydA:
undetectable
3sueA-3wydA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3s 6-PHOSPHOFRUCTOKINAS
E


(Bacillus
subtilis)
PF00365
(PFK)
5 GLY A 254
ILE A 100
GLY A 138
ALA A  18
ALA A  19
None
1.08A 3sueA-4a3sA:
undetectable
3sueA-4a3sA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aec CYSTEINE SYNTHASE,
MITOCHONDRIAL


(Arabidopsis
thaliana)
PF00291
(PALP)
5 GLY A 333
GLY A 375
PHE A 403
ALA A 381
ALA A 382
PLP  A 500 (-3.6A)
None
None
None
None
1.07A 3sueA-4aecA:
undetectable
3sueA-4aecA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A


(Catenulispora
acidiphila)
PF13768
(VWA_3)
5 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
None
0.91A 3sueA-4fx5A:
undetectable
3sueA-4fx5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN


(Eubacterium
ventriosum)
PF13306
(LRR_5)
5 GLY A 185
ILE A 253
GLY A 247
SER A 245
ALA A 266
None
0.93A 3sueA-4h09A:
undetectable
3sueA-4h09A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 GLY A  38
GLY A 272
SER A 752
ALA A 239
ALA A 236
None
1.06A 3sueA-4iigA:
undetectable
3sueA-4iigA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inl SERINE PROTEASE SPLD

(Staphylococcus
aureus)
PF13365
(Trypsin_2)
5 HIS A  39
ASP A  78
GLY A 154
SER A 156
ALA A 173
None
0.77A 3sueA-4inlA:
9.0
3sueA-4inlA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A  48
ILE A 192
GLY A 301
ALA A 201
ALA A 202
NAD  A 403 (-3.0A)
None
NAD  A 403 ( 3.7A)
None
None
1.06A 3sueA-4jlwA:
undetectable
3sueA-4jlwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
5 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
None
1.07A 3sueA-4kpgA:
undetectable
3sueA-4kpgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN


(Mycolicibacterium
smegmatis)
PF00106
(adh_short)
5 GLY A  98
ASP A 101
ILE A  67
ALA A  47
ALA A  43
None
0.98A 3sueA-4kzpA:
undetectable
3sueA-4kzpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
5 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
None
0.98A 3sueA-4m1zA:
undetectable
3sueA-4m1zA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8s PUTATIVE
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE


(Neisseria
meningitidis)
PF13561
(adh_short_C2)
5 GLY A  21
ASP A  26
ILE A  10
ALA A  29
ALA A  33
None
1.07A 3sueA-4m8sA:
undetectable
3sueA-4m8sA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mow GLUCOSE
1-DEHYDROGENASE


(Burkholderia
cenocepacia)
PF13561
(adh_short_C2)
5 GLY A  83
ASP A  86
ILE A  51
ALA A  31
ALA A  27
None
1.05A 3sueA-4mowA:
undetectable
3sueA-4mowA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN


(Bordetella
pertussis)
PF13458
(Peripla_BP_6)
5 GLN A 105
ILE A 151
GLY A 210
ALA A 232
ALA A 207
None
1.04A 3sueA-4mptA:
undetectable
3sueA-4mptA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP


(Lactococcus
lactis)
PF00082
(Peptidase_S8)
5 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
None
0.72A 3sueA-4mzdA:
undetectable
3sueA-4mzdA:
17.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
11 GLN A  41
HIS A  57
GLY A  58
ASP A  81
ILE A 132
LYS A 136
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
2R8  A 301 ( 3.5A)
2R8  A 301 (-3.3A)
2R8  A 301 (-3.5A)
2R8  A 301 (-3.6A)
2R8  A 301 (-4.3A)
GOL  A 310 ( 2.6A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-2.6A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
0.40A 3sueA-4nwkA:
35.7
3sueA-4nwkA:
98.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
6 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
ALA B 290
None
1.40A 3sueA-4ov6B:
undetectable
3sueA-4ov6B:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1


(Nitrosomonas
europaea)
PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth)
5 HIS A 273
GLY A 274
ASP A 404
GLY A 288
ALA A 426
None
0.91A 3sueA-4rbnA:
undetectable
3sueA-4rbnA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv1 ENGINEERED PROTEIN
OR497


(synthetic
construct)
PF00514
(Arm)
5 GLY A 284
ILE A 334
GLY A 326
ALA A 321
ALA A 361
None
1.08A 3sueA-4rv1A:
undetectable
3sueA-4rv1A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE


(Burkholderia
cenocepacia)
PF00106
(adh_short)
5 GLY A  82
ASP A  85
ILE A  50
ALA A  31
ALA A  27
None
1.03A 3sueA-4trrA:
undetectable
3sueA-4trrA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
5 HIS A 311
GLY A 309
ILE A 284
GLY A 306
ALA A 282
None
1.00A 3sueA-4woeA:
undetectable
3sueA-4woeA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus)
PF05416
(Peptidase_C37)
5 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
None
0.66A 3sueA-4x2xA:
7.5
3sueA-4x2xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcm CELL WALL-BINDING
ENDOPEPTIDASE-RELATE
D PROTEIN


(Thermus
thermophilus)
PF00877
(NLPC_P60)
PF01476
(LysM)
5 GLY A 221
ILE A 226
GLY A 140
PHE A 158
ALA A 215
None
1.06A 3sueA-4xcmA:
undetectable
3sueA-4xcmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN


(Campylobacter
jejuni)
PF07196
(Flagellin_IN)
PF07559
(FlaE)
5 GLY A 524
ASP A 521
ILE A 561
GLY A 490
ALA A 529
None
1.07A 3sueA-5az4A:
undetectable
3sueA-5az4A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1


(Chaetomium
thermophilum)
PF00400
(WD40)
PF08154
(NLE)
5 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
None
1.04A 3sueA-5cykA:
undetectable
3sueA-5cykA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1


(Escherichia
coli)
no annotation 5 GLN D  90
GLY D  89
ILE D 265
ALA D 193
ALA D 194
None
1.07A 3sueA-5dljD:
undetectable
3sueA-5dljD:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C)
PF02907
(Peptidase_S29)
9 GLN A1041
HIS A1057
GLY A1058
ASP A1081
ILE A1132
GLY A1137
PHE A1154
ALA A1156
ALA A1157
5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
0.33A 3sueA-5eqqA:
35.7
3sueA-5eqqA:
93.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE


(Thioalkalivibrio
paradoxus)
no annotation 5 GLY A 273
ILE A 225
GLY A 200
PHE A 229
ALA A 227
None
1.02A 3sueA-5f75A:
undetectable
3sueA-5f75A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN


(Homo sapiens)
PF00089
(Trypsin)
5 HIS A  57
ASP A 102
LYS A 192
GLY A 193
SER A 195
None
0.76A 3sueA-5f8zA:
10.1
3sueA-5f8zA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL


(Rhodoferax
ferrireducens)
PF03480
(DctP)
5 GLN A 277
GLY A 147
ILE A 195
ALA A 208
ALA A 207
BEZ  A 401 (-3.9A)
None
None
None
None
0.83A 3sueA-5im2A:
undetectable
3sueA-5im2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens)
PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C)
5 GLY A 117
GLY A 327
SER A 325
PHE A 324
ALA A 227
None
1.00A 3sueA-5kp7A:
undetectable
3sueA-5kp7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kws GALACTOSE-BINDING
PROTEIN


(Yersinia pestis)
PF13407
(Peripla_BP_4)
5 GLY A 281
ILE A   5
LYS A 276
ALA A 274
ALA A 273
None
None
EDO  A 406 ( 2.7A)
GOL  A 405 (-3.5A)
None
1.08A 3sueA-5kwsA:
undetectable
3sueA-5kwsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus)
PF07859
(Abhydrolase_3)
5 HIS A 281
ASP A 251
ILE A  97
GLY A  83
SER A 156
None
0.79A 3sueA-5l2pA:
undetectable
3sueA-5l2pA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum)
PF07859
(Abhydrolase_3)
5 HIS A 317
ASP A 287
GLY A 117
SER A 190
ALA A 320
None
1.02A 3sueA-5mifA:
undetectable
3sueA-5mifA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora)
no annotation 5 HIS A 331
ASP A 304
GLY A 150
SER A 217
ALA A 239
None
1.05A 3sueA-5no5A:
undetectable
3sueA-5no5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oex -

(-)
no annotation 5 GLY A 273
ILE A 225
GLY A 200
PHE A 229
ALA A 227
None
0.97A 3sueA-5oexA:
undetectable
3sueA-5oexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN


(Homo sapiens)
PF00089
(Trypsin)
PF09064
(Tme5_EGF_like)
5 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
0.73A 3sueA-5to3B:
9.8
3sueA-5to3B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9)
5 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
None
0.93A 3sueA-5vlhA:
undetectable
3sueA-5vlhA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9)
5 HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
None
0.96A 3sueA-5vlhA:
undetectable
3sueA-5vlhA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C)
no annotation 9 GLN A  41
HIS A  57
GLY A  58
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
None
0.66A 3sueA-5wdxA:
27.6
3sueA-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C)
no annotation 9 HIS A  57
GLY A  58
ASP A  81
ILE A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
None
0.47A 3sueA-5wdxA:
27.6
3sueA-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epi ZETA_1 TOXIN

(Neisseria
gonorrhoeae)
no annotation 5 GLY B 134
ASP B  56
ILE B   8
SER B  86
ALA B  82
BNW  B 501 (-3.5A)
BNW  B 501 (-3.2A)
None
BNW  B 501 ( 3.8A)
None
1.05A 3sueA-6epiB:
undetectable
3sueA-6epiB:
16.04