SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUE_A_SUEA1201_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a8q | BROMOPEROXIDASE A1 (Kitasatosporaaureofaciens) |
PF00561(Abhydrolase_1) | 5 | HIS A 252ASP A 223GLY A 27SER A 94ALA A 255 | None | 0.95A | 3sueA-1a8qA:undetectable | 3sueA-1a8qA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ahi | 7ALPHA-HYDROXYSTEROIDDEHYDROGENASE (Escherichiacoli) |
PF13561(adh_short_C2) | 5 | GLY A 87ASP A 90ILE A 55ALA A 36ALA A 32 | None | 1.02A | 3sueA-1ahiA:undetectable | 3sueA-1ahiA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aj8 | CITRATE SYNTHASE (Pyrococcusfuriosus) |
PF00285(Citrate_synt) | 5 | GLY A 283ILE A 332GLY A 316PHE A 275ALA A 181 | None | 1.00A | 3sueA-1aj8A:undetectable | 3sueA-1aj8A:19.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1cu1 | PROTEIN(PROTEASE/HELICASENS3) (Hepacivirus C) |
PF02907(Peptidase_S29)PF07652(Flavi_DEAD) | 9 | GLN A 41HIS A 57GLY A 58ASP A 81GLY A 137SER A 139PHE A 154ALA A 156ALA A 157 | None | 0.66A | 3sueA-1cu1A:34.8 | 3sueA-1cu1A:80.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1cu1 | PROTEIN(PROTEASE/HELICASENS3) (Hepacivirus C) |
PF02907(Peptidase_S29)PF07652(Flavi_DEAD) | 8 | HIS A 57GLY A 58ASP A 81LYS A 136GLY A 137SER A 139ALA A 156ALA A 157 | None | 0.69A | 3sueA-1cu1A:34.8 | 3sueA-1cu1A:80.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eg7 | FORMYLTETRAHYDROFOLATE SYNTHETASE (Moorellathermoacetica) |
PF01268(FTHFS) | 5 | HIS A1280GLY A1281ILE A1286GLY A1272ALA A1212 | None | 1.07A | 3sueA-1eg7A:undetectable | 3sueA-1eg7A:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1elv | COMPLEMENT C1SCOMPONENT (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin) | 5 | HIS A 460ASP A 514LYS A 614GLY A 615SER A 617 | SO4 A2001 ( 3.9A)NoneSO4 A2001 (-2.9A)SO4 A2001 (-4.1A)SO4 A2001 ( 2.7A) | 0.83A | 3sueA-1elvA:11.3 | 3sueA-1elvA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ep5 | CAPSID PROTEIN C (Venezuelanequineencephalitisvirus) |
no annotation | 5 | HIS B 152ASP B 174LYS B 223GLY B 224SER B 226 | None | 1.01A | 3sueA-1ep5B:10.9 | 3sueA-1ep5B:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evq | SERINE HYDROLASE (Alicyclobacillusacidocaldarius) |
PF07859(Abhydrolase_3) | 5 | HIS A 282ASP A 252GLY A 82SER A 155ALA A 285 | EPE A 455 (-4.0A)NoneEPE A 455 (-3.5A)EPE A 455 (-1.4A)None | 0.99A | 3sueA-1evqA:undetectable | 3sueA-1evqA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1juh | QUERCETIN2,3-DIOXYGENASE (Aspergillusjaponicus) |
no annotation | 5 | GLY A 329ILE A 287PHE A 276ALA A 275ALA A 301 | None | 1.04A | 3sueA-1juhA:undetectable | 3sueA-1juhA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfw | CHITINASE B (Arthrobactersp. TAD20) |
PF00704(Glyco_hydro_18) | 5 | GLY A 195ILE A 58GLY A 204ALA A 146ALA A 145 | None | 0.88A | 3sueA-1kfwA:undetectable | 3sueA-1kfwA:17.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 5 | GLN A 41HIS A 57ASP A 81GLY A 137SER A 139 | None | 0.95A | 3sueA-1ns3A:30.8 | 3sueA-1ns3A:77.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ns3 | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 8 | GLN A 41HIS A 57GLY A 58ASP A 81GLY A 137PHE A 154ALA A 156ALA A 157 | None | 0.69A | 3sueA-1ns3A:30.8 | 3sueA-1ns3A:77.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p3c | GLUTAMYL-ENDOPEPTIDASE (Bacillusintermedius) |
PF00089(Trypsin) | 5 | HIS A 47ASP A 97GLY A 169SER A 171ALA A 188 | None | 0.74A | 3sueA-1p3cA:10.6 | 3sueA-1p3cA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9h | INVASIN (Yersiniaenterocolitica) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 76GLY A 104SER A 93ALA A 95ALA A 109 | None | 1.08A | 3sueA-1p9hA:undetectable | 3sueA-1p9hA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9h | INVASIN (Yersiniaenterocolitica) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 90GLY A 118SER A 107ALA A 109ALA A 123 | None | 1.08A | 3sueA-1p9hA:undetectable | 3sueA-1p9hA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9h | INVASIN (Yersiniaenterocolitica) |
PF05658(YadA_head)PF05662(YadA_stalk) | 5 | GLY A 131ILE A 171GLY A 158SER A 147ALA A 149 | None | 0.90A | 3sueA-1p9hA:undetectable | 3sueA-1p9hA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pvd | PYRUVATEDECARBOXYLASE (Saccharomycescerevisiae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLN A 160GLY A 66ILE A 85ALA A 58ALA A 55 | None | 1.02A | 3sueA-1pvdA:undetectable | 3sueA-1pvdA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgf | NERVE GROWTH FACTOR (Mus musculus) |
PF00089(Trypsin) | 5 | HIS G 57ASP G 102LYS G 192GLY G 193SER G 195 | None | 0.79A | 3sueA-1sgfG:10.3 | 3sueA-1sgfG:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1szn | ALPHA-GALACTOSIDASE (Trichodermareesei) |
PF16499(Melibiase_2) | 5 | GLY A 66ASP A 117GLY A 62ALA A 109ALA A 102 | None | 1.02A | 3sueA-1sznA:undetectable | 3sueA-1sznA:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uz5 | 402AA LONGHYPOTHETICALMOLYBDOPTERINBIOSYNTHESIS MOEAPROTEIN (Pyrococcushorikoshii) |
PF00994(MoCF_biosynth)PF03453(MoeA_N)PF03454(MoeA_C) | 5 | ASP A 65ILE A 101GLY A 109ALA A 98ALA A 99 | None | 1.06A | 3sueA-1uz5A:undetectable | 3sueA-1uz5A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9c | PRECORRIN-8X METHYLMUTASE (Thermusthermophilus) |
PF02570(CbiC) | 5 | GLY A 208ILE A 181GLY A 59ALA A 199ALA A 196 | None | 1.01A | 3sueA-1v9cA:undetectable | 3sueA-1v9cA:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdw | TRYPTOPHAN SYNTHASEBETA CHAIN 1 (Pyrococcusfuriosus) |
PF00291(PALP) | 5 | GLN B 109GLY B 298ILE B 341GLY B 372ALA B 347 | PLP B 400 (-3.4A)PLP B 400 (-3.8A)NonePLP B 400 (-3.4A)None | 1.02A | 3sueA-1wdwB:undetectable | 3sueA-1wdwB:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y8t | HYPOTHETICAL PROTEINRV0983 (Mycobacteriumtuberculosis) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | HIS A 49ASP A 88GLY A 167SER A 169ALA A 186 | None | 0.83A | 3sueA-1y8tA:12.7 | 3sueA-1y8tA:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z68 | FIBROBLASTACTIVATION PROTEIN,ALPHA SUBUNIT (Homo sapiens) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | GLN A 483ILE A 424GLY A 479ALA A 463ALA A 453 | None | 1.02A | 3sueA-1z68A:undetectable | 3sueA-1z68A:13.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zxx | 6-PHOSPHOFRUCTOKINASE (Lactobacillusdelbrueckii) |
PF00365(PFK) | 5 | GLY A 254ILE A 100GLY A 138ALA A 18ALA A 19 | None | 0.99A | 3sueA-1zxxA:undetectable | 3sueA-1zxxA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c7b | CARBOXYLESTERASE (unculturedarchaeon) |
PF07859(Abhydrolase_3) | 5 | HIS A 281ASP A 251ILE A 95GLY A 81SER A 154 | None | 0.93A | 3sueA-2c7bA:undetectable | 3sueA-2c7bA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ea3 | CHYMOTRYPSIN (Cellulomonasbogoriensis) |
PF00089(Trypsin) | 5 | GLN A 167ILE A 108GLY A 149ALA A 87ALA A 88 | None | 0.99A | 3sueA-2ea3A:11.9 | 3sueA-2ea3A:25.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gvk | HEME PEROXIDASE (Bacteroidesthetaiotaomicron) |
PF04261(Dyp_perox) | 5 | GLY A 18ILE A 25SER A 65PHE A 64ALA A 114 | None | 1.06A | 3sueA-2gvkA:undetectable | 3sueA-2gvkA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isq | CYSTEINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 5 | GLY A 225GLY A 267PHE A 295ALA A 273ALA A 274 | PLP A 400 (-3.5A)NoneNoneNoneNone | 0.94A | 3sueA-2isqA:undetectable | 3sueA-2isqA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfk | 6-PHOSPHOFRUCTOKINASE ISOZYME I (Escherichiacoli) |
PF00365(PFK) | 5 | GLY A 254ILE A 100GLY A 138ALA A 18ALA A 19 | None | 1.02A | 3sueA-2pfkA:undetectable | 3sueA-2pfkA:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po4 | VIRION RNAPOLYMERASE (Escherichiavirus N4) |
no annotation | 5 | GLY A 50ILE A 214GLY A 219SER A 46ALA A 158 | None | 0.95A | 3sueA-2po4A:undetectable | 3sueA-2po4A:11.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjp | CYTOCHROME BCYTOCHROME C1 (Rhodobactersphaeroides) |
PF00032(Cytochrom_B_C)PF00033(Cytochrome_B)PF02167(Cytochrom_C1) | 5 | ASP A 278ILE B 131GLY B 109ALA B 106ALA B 104 | NoneHEM B 301 ( 4.3A)NoneNoneNone | 0.86A | 3sueA-2qjpA:undetectable | 3sueA-2qjpA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2uvd | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Bacillusanthracis) |
PF13561(adh_short_C2) | 5 | GLY A 81ASP A 84ILE A 49ALA A 29ALA A 25 | None | 1.02A | 3sueA-2uvdA:undetectable | 3sueA-2uvdA:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vid | SERINE PROTEASE SPLB (Staphylococcusaureus) |
PF00089(Trypsin) | 5 | HIS A 39ASP A 77GLY A 155SER A 157ALA A 174 | None | 0.77A | 3sueA-2vidA:12.1 | 3sueA-2vidA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vk4 | PYRUVATEDECARBOXYLASE (Kluyveromyceslactis) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLN A 160GLY A 66ILE A 85ALA A 58ALA A 55 | None | 1.05A | 3sueA-2vk4A:undetectable | 3sueA-2vk4A:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wge | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 1 (Mycobacteriumtuberculosis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 236GLY A 318PHE A 230ALA A 338ALA A 310 | NoneTLM A1424 ( 4.0A)NoneNoneNone | 1.06A | 3sueA-2wgeA:undetectable | 3sueA-2wgeA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a5v | ALPHA-GALACTOSIDASE (Umbelopsisvinacea) |
PF16499(Melibiase_2) | 5 | GLY A 271ILE A 83GLY A 12ALA A 31ALA A 32 | None | 0.99A | 3sueA-3a5vA:undetectable | 3sueA-3a5vA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai7 | XYLULOSE-5-PHOSPHATE/FRUCTOSE-6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacteriumlongum) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 5 | GLN A 606GLY A 604ILE A 655ALA A 647ALA A 646 | None | 1.05A | 3sueA-3ai7A:undetectable | 3sueA-3ai7A:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aja | PUTATIVEUNCHARACTERIZEDPROTEIN (Mycolicibacteriumsmegmatis) |
PF01083(Cutinase) | 5 | HIS A 300GLY A 293ASP A 269GLY A 83SER A 176 | None | 0.98A | 3sueA-3ajaA:undetectable | 3sueA-3ajaA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ak5 | HEMOGLOBIN-BINDINGPROTEASE HBP (Escherichiacoli) |
PF02395(Peptidase_S6) | 5 | HIS A 125ASP A 153GLY A 257SER A 259ALA A 281 | None | 0.76A | 3sueA-3ak5A:6.8 | 3sueA-3ak5A:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bw2 | 2-NITROPROPANEDIOXYGENASE (Streptomycesansochromogenes) |
PF03060(NMO) | 5 | GLY A 195ILE A 223GLY A 216ALA A 213ALA A 234 | NoneNoneFMN A 370 (-3.3A)NoneNone | 1.08A | 3sueA-3bw2A:undetectable | 3sueA-3bw2A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3p | METHYLTRANSFERASE (Geobactersulfurreducens) |
PF01596(Methyltransf_3) | 5 | GLY A 164ASP A 132ILE A 195GLY A 199ALA A 157 | None | 1.01A | 3sueA-3c3pA:undetectable | 3sueA-3c3pA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g6s | PUTATIVEENDONUCLEASE/EXONUCLEASE/PHOSPHATASEFAMILY PROTEIN (Bacteroidesvulgatus) |
PF03372(Exo_endo_phos) | 5 | GLN A 45GLY A 171ILE A 65ALA A 134ALA A 121 | None | 1.02A | 3sueA-3g6sA:undetectable | 3sueA-3g6sA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcw | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 6 | GLN A 382HIS A 226ASP A 186GLY A 384SER A 386ALA A 290 | None | 1.40A | 3sueA-3gcwA:undetectable | 3sueA-3gcwA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hea | ARYLESTERASE (Pseudomonasfluorescens) |
PF00561(Abhydrolase_1) | 5 | HIS A 251ASP A 222GLY A 27SER A 94ALA A 254 | EEE A 300 (-4.3A)NoneEEE A 300 (-3.4A)EEE A 300 (-1.4A)None | 0.96A | 3sueA-3heaA:undetectable | 3sueA-3heaA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3js4 | SUPEROXIDE DISMUTASE (Anaplasmaphagocytophilum) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | ASP A 150ILE A 56GLY A 67ALA A 75ALA A 74 | None | 1.06A | 3sueA-3js4A:undetectable | 3sueA-3js4A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kxq | TRIOSEPHOSPHATEISOMERASE (Bartonellahenselae) |
PF00121(TIM) | 5 | GLN A 68ILE A 63GLY A 11SER A 238LYS A 240 | NoneNoneNoneNoneEDO A 302 (-3.1A) | 1.04A | 3sueA-3kxqA:undetectable | 3sueA-3kxqA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfh | EPIDERMIN LEADERPEPTIDE PROCESSINGSERINE PROTEASE EPIP (Staphylococcusaureus) |
PF00082(Peptidase_S8) | 5 | GLN A 389HIS A 187ASP A 140GLY A 391SER A 393 | None | 0.87A | 3sueA-3qfhA:undetectable | 3sueA-3qfhA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qo6 | PROTEASE DO-LIKE 1,CHLOROPLASTIC (Arabidopsisthaliana) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | HIS A 173ASP A 203GLY A 280SER A 282ALA A 299 | None | 0.79A | 3sueA-3qo6A:8.8 | 3sueA-3qo6A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rim | TRANSKETOLASE (Mycobacteriumtuberculosis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | GLY A 461ILE A 515GLY A 547ALA A 478ALA A 479 | None | 0.85A | 3sueA-3rimA:undetectable | 3sueA-3rimA:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s29 | SUCROSE SYNTHASE 1 (Arabidopsisthaliana) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 5 | HIS A 287GLY A 288ASP A 417GLY A 302ALA A 439 | FRU A 902 (-4.0A)NoneNoneFRU A 902 ( 2.2A)FRU A 902 ( 3.7A) | 0.83A | 3sueA-3s29A:undetectable | 3sueA-3s29A:11.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s29 | SUCROSE SYNTHASE 1 (Arabidopsisthaliana) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 5 | HIS A 287GLY A 288ASP A 417GLY A 303ALA A 439 | FRU A 902 (-4.0A)NoneNoneUDP A 901 ( 2.9A)FRU A 902 ( 3.7A) | 0.99A | 3sueA-3s29A:undetectable | 3sueA-3s29A:11.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3stj | PROTEASE DEGQ (Escherichiacoli) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | HIS A 82ASP A 112GLY A 185SER A 187ALA A 204 | None | 0.68A | 3sueA-3stjA:9.4 | 3sueA-3stjA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttf | TRANSCRIPTIONALREGULATORY PROTEIN (Escherichiacoli) |
PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 5 | ILE A 350LYS A 219GLY A 220ALA A 331ALA A 337 | None | 1.05A | 3sueA-3ttfA:undetectable | 3sueA-3ttfA:14.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ufa | SERINE PROTEASE SPLA (Staphylococcusaureus) |
PF00089(Trypsin) | 5 | HIS A 39ASP A 78GLY A 152SER A 154ALA A 171 | VPF A 201 (-3.8A)NoneVPF A 201 (-3.3A)VPF A 201 (-1.7A)VPF A 201 (-4.9A) | 0.83A | 3sueA-3ufaA:11.8 | 3sueA-3ufaA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v2g | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | GLY A 108ASP A 111ILE A 76ALA A 56ALA A 52 | None | 0.97A | 3sueA-3v2gA:undetectable | 3sueA-3v2gA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wj2 | CARBOXYLESTERASE (Ferroplasmaacidiphilum) |
PF07859(Abhydrolase_3) | 5 | HIS A 281ASP A 251GLY A 84SER A 156ALA A 284 | None | 1.04A | 3sueA-3wj2A:undetectable | 3sueA-3wj2A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wyd | LC-EST1C (unculturedorganism) |
PF00326(Peptidase_S9) | 5 | HIS A 479ASP A 447GLY A 327SER A 399ALA A 483 | None | 0.94A | 3sueA-3wydA:undetectable | 3sueA-3wydA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a3s | 6-PHOSPHOFRUCTOKINASE (Bacillussubtilis) |
PF00365(PFK) | 5 | GLY A 254ILE A 100GLY A 138ALA A 18ALA A 19 | None | 1.08A | 3sueA-4a3sA:undetectable | 3sueA-4a3sA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aec | CYSTEINE SYNTHASE,MITOCHONDRIAL (Arabidopsisthaliana) |
PF00291(PALP) | 5 | GLY A 333GLY A 375PHE A 403ALA A 381ALA A 382 | PLP A 500 (-3.6A)NoneNoneNoneNone | 1.07A | 3sueA-4aecA:undetectable | 3sueA-4aecA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fx5 | VON WILLEBRANDFACTOR TYPE A (Catenulisporaacidiphila) |
PF13768(VWA_3) | 5 | GLY A 284ILE A 179GLY A 184PHE A 186ALA A 188 | None | 0.91A | 3sueA-4fx5A:undetectable | 3sueA-4fx5A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h09 | HYPOTHETICAL LEUCINERICH REPEAT PROTEIN (Eubacteriumventriosum) |
PF13306(LRR_5) | 5 | GLY A 185ILE A 253GLY A 247SER A 245ALA A 266 | None | 0.93A | 3sueA-4h09A:undetectable | 3sueA-4h09A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iig | BETA-GLUCOSIDASE 1 (Aspergillusaculeatus) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | GLY A 38GLY A 272SER A 752ALA A 239ALA A 236 | None | 1.06A | 3sueA-4iigA:undetectable | 3sueA-4iigA:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inl | SERINE PROTEASE SPLD (Staphylococcusaureus) |
PF13365(Trypsin_2) | 5 | HIS A 39ASP A 78GLY A 154SER A 156ALA A 173 | None | 0.77A | 3sueA-4inlA:9.0 | 3sueA-4inlA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlw | GLUTATHIONE-INDEPENDENT FORMALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 48ILE A 192GLY A 301ALA A 201ALA A 202 | NAD A 403 (-3.0A)NoneNAD A 403 ( 3.7A)NoneNone | 1.06A | 3sueA-4jlwA:undetectable | 3sueA-4jlwA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpg | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | HIS A 123ASP A 92GLY A 332SER A 334ALA A 204 | None | 1.07A | 3sueA-4kpgA:undetectable | 3sueA-4kpgA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kzp | OXIDOREDUCTASE,SHORT CHAINDEHYDROGENASE/REDUCTASE FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF00106(adh_short) | 5 | GLY A 98ASP A 101ILE A 67ALA A 47ALA A 43 | None | 0.98A | 3sueA-4kzpA:undetectable | 3sueA-4kzpA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m1z | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | HIS A 123ASP A 92GLY A 332SER A 334ALA A 204 | None | 0.98A | 3sueA-4m1zA:undetectable | 3sueA-4m1zA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m8s | PUTATIVE3-OXOACYL-[ACYL-CARRIER PROTEIN]REDUCTASE (Neisseriameningitidis) |
PF13561(adh_short_C2) | 5 | GLY A 21ASP A 26ILE A 10ALA A 29ALA A 33 | None | 1.07A | 3sueA-4m8sA:undetectable | 3sueA-4m8sA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mow | GLUCOSE1-DEHYDROGENASE (Burkholderiacenocepacia) |
PF13561(adh_short_C2) | 5 | GLY A 83ASP A 86ILE A 51ALA A 31ALA A 27 | None | 1.05A | 3sueA-4mowA:undetectable | 3sueA-4mowA:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mpt | PUTATIVELEU/ILE/VAL-BINDINGPROTEIN (Bordetellapertussis) |
PF13458(Peripla_BP_6) | 5 | GLN A 105ILE A 151GLY A 210ALA A 232ALA A 207 | None | 1.04A | 3sueA-4mptA:undetectable | 3sueA-4mptA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mzd | NISIN LEADERPEPTIDE-PROCESSINGSERINE PROTEASE NISP (Lactococcuslactis) |
PF00082(Peptidase_S8) | 5 | HIS A 306ASP A 259GLY A 510SER A 512ALA A 364 | None | 0.72A | 3sueA-4mzdA:undetectable | 3sueA-4mzdA:17.66 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4nwk | HCV NS3 1A PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 11 | GLN A 41HIS A 57GLY A 58ASP A 81ILE A 132LYS A 136GLY A 137SER A 139PHE A 154ALA A 156ALA A 157 | 2R8 A 301 ( 3.5A)2R8 A 301 (-3.3A)2R8 A 301 (-3.5A)2R8 A 301 (-3.6A)2R8 A 301 (-4.3A)GOL A 310 ( 2.6A)GOL A 305 ( 3.2A)2R8 A 301 (-2.6A)2R8 A 301 (-3.7A)2R8 A 301 (-3.1A)2R8 A 301 (-3.8A) | 0.40A | 3sueA-4nwkA:35.7 | 3sueA-4nwkA:98.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ov6 | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 6 | GLN B 382HIS B 226ASP B 186GLY B 384SER B 386ALA B 290 | None | 1.40A | 3sueA-4ov6B:undetectable | 3sueA-4ov6B:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rbn | SUCROSESYNTHASE:GLYCOSYLTRANSFERASES GROUP 1 (Nitrosomonaseuropaea) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 5 | HIS A 273GLY A 274ASP A 404GLY A 288ALA A 426 | None | 0.91A | 3sueA-4rbnA:undetectable | 3sueA-4rbnA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rv1 | ENGINEERED PROTEINOR497 (syntheticconstruct) |
PF00514(Arm) | 5 | GLY A 284ILE A 334GLY A 326ALA A 321ALA A 361 | None | 1.08A | 3sueA-4rv1A:undetectable | 3sueA-4rv1A:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4trr | PUTATIVED-BETA-HYDROXYBUTYRATE DEHYDROGENASE (Burkholderiacenocepacia) |
PF00106(adh_short) | 5 | GLY A 82ASP A 85ILE A 50ALA A 31ALA A 27 | None | 1.03A | 3sueA-4trrA:undetectable | 3sueA-4trrA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4woe | TAUROCYAMINE KINASE (Schistosomamansoni) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 5 | HIS A 311GLY A 309ILE A 284GLY A 306ALA A 282 | None | 1.00A | 3sueA-4woeA:undetectable | 3sueA-4woeA:16.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x2x | NS6 PROTEASE (Norwalk virus) |
PF05416(Peptidase_C37) | 5 | HIS A 30ASP A 54GLY A 137ALA A 159ALA A 160 | None | 0.66A | 3sueA-4x2xA:7.5 | 3sueA-4x2xA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xcm | CELL WALL-BINDINGENDOPEPTIDASE-RELATED PROTEIN (Thermusthermophilus) |
PF00877(NLPC_P60)PF01476(LysM) | 5 | GLY A 221ILE A 226GLY A 140PHE A 158ALA A 215 | None | 1.06A | 3sueA-4xcmA:undetectable | 3sueA-4xcmA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5az4 | FLAGELLAR HOOKSUBUNIT PROTEIN (Campylobacterjejuni) |
PF07196(Flagellin_IN)PF07559(FlaE) | 5 | GLY A 524ASP A 521ILE A 561GLY A 490ALA A 529 | None | 1.07A | 3sueA-5az4A:undetectable | 3sueA-5az4A:14.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyk | RIBOSOME BIOGENESISPROTEIN YTM1 (Chaetomiumthermophilum) |
PF00400(WD40)PF08154(NLE) | 5 | HIS A 224GLY A 223ASP A 246ALA A 243ALA A 303 | None | 1.04A | 3sueA-5cykA:undetectable | 3sueA-5cykA:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dlj | CRISPR-ASSOCIATEDENDONUCLEASE CAS1 (Escherichiacoli) |
no annotation | 5 | GLN D 90GLY D 89ILE D 265ALA D 193ALA D 194 | None | 1.07A | 3sueA-5dljD:undetectable | 3sueA-5dljD:21.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5eqq | NS3 PROTEASE (Hepacivirus C) |
PF02907(Peptidase_S29) | 9 | GLN A1041HIS A1057GLY A1058ASP A1081ILE A1132GLY A1137PHE A1154ALA A1156ALA A1157 | 5RS A1203 (-2.9A)5RS A1203 (-2.5A)5RS A1203 ( 2.9A)5RS A1203 (-3.5A)5RS A1203 ( 4.1A)5RS A1203 (-3.2A)5RS A1203 (-3.3A)5RS A1203 (-2.9A)5RS A1203 (-3.5A) | 0.33A | 3sueA-5eqqA:35.7 | 3sueA-5eqqA:93.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f75 | THIOCYANATEDEHYDROGENASE (Thioalkalivibrioparadoxus) |
no annotation | 5 | GLY A 273ILE A 225GLY A 200PHE A 229ALA A 227 | None | 1.02A | 3sueA-5f75A:undetectable | 3sueA-5f75A:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f8z | PLASMA KALLIKREINLIGHT CHAIN (Homo sapiens) |
PF00089(Trypsin) | 5 | HIS A 57ASP A 102LYS A 192GLY A 193SER A 195 | None | 0.76A | 3sueA-5f8zA:10.1 | 3sueA-5f8zA:27.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5im2 | TWIN-ARGININETRANSLOCATIONPATHWAY SIGNAL (Rhodoferaxferrireducens) |
PF03480(DctP) | 5 | GLN A 277GLY A 147ILE A 195ALA A 208ALA A 207 | BEZ A 401 (-3.9A)NoneNoneNoneNone | 0.83A | 3sueA-5im2A:undetectable | 3sueA-5im2A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kp7 | CURD (Mooreaproducens) |
PF01154(HMG_CoA_synt_N)PF08540(HMG_CoA_synt_C) | 5 | GLY A 117GLY A 327SER A 325PHE A 324ALA A 227 | None | 1.00A | 3sueA-5kp7A:undetectable | 3sueA-5kp7A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kws | GALACTOSE-BINDINGPROTEIN (Yersinia pestis) |
PF13407(Peripla_BP_4) | 5 | GLY A 281ILE A 5LYS A 276ALA A 274ALA A 273 | NoneNoneEDO A 406 ( 2.7A)GOL A 405 (-3.5A)None | 1.08A | 3sueA-5kwsA:undetectable | 3sueA-5kwsA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l2p | ARYLESTERASE (Sulfolobussolfataricus) |
PF07859(Abhydrolase_3) | 5 | HIS A 281ASP A 251ILE A 97GLY A 83SER A 156 | None | 0.79A | 3sueA-5l2pA:undetectable | 3sueA-5l2pA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mif | 'CARBOXYL ESTERASE 2 (Tubermelanosporum) |
PF07859(Abhydrolase_3) | 5 | HIS A 317ASP A 287GLY A 117SER A 190ALA A 320 | None | 1.02A | 3sueA-5mifA:undetectable | 3sueA-5mifA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5no5 | ABYA5 (Verrucosispora) |
no annotation | 5 | HIS A 331ASP A 304GLY A 150SER A 217ALA A 239 | None | 1.05A | 3sueA-5no5A:undetectable | 3sueA-5no5A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oex | - (-) |
no annotation | 5 | GLY A 273ILE A 225GLY A 200PHE A 229ALA A 227 | None | 0.97A | 3sueA-5oexA:undetectable | 3sueA-5oexA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5to3 | PROTHROMBIN,THROMBOMODULIN (Homo sapiens) |
PF00089(Trypsin)PF09064(Tme5_EGF_like) | 5 | HIS B 58ASP B 114GLY B 218SER B 220ALA B 242 | 0G6 B 501 (-2.5A)None0G6 B 501 (-3.9A)0G6 B 501 (-1.3A)0G6 B 501 (-3.4A) | 0.73A | 3sueA-5to3B:9.8 | 3sueA-5to3B:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vlh | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8)PF05922(Inhibitor_I9) | 5 | GLN A 382HIS A 226ASP A 186GLY A 384SER A 386 | None | 0.93A | 3sueA-5vlhA:undetectable | 3sueA-5vlhA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vlh | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8)PF05922(Inhibitor_I9) | 5 | HIS A 226ASP A 186GLY A 384SER A 386ALA A 290 | None | 0.96A | 3sueA-5vlhA:undetectable | 3sueA-5vlhA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdx | JFH-1 NS3 (Hepacivirus C) |
no annotation | 9 | GLN A 41HIS A 57GLY A 58ILE A 132GLY A 137SER A 139PHE A 154ALA A 156ALA A 157 | None | 0.66A | 3sueA-5wdxA:27.6 | 3sueA-5wdxA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wdx | JFH-1 NS3 (Hepacivirus C) |
no annotation | 9 | HIS A 57GLY A 58ASP A 81ILE A 132GLY A 137SER A 139PHE A 154ALA A 156ALA A 157 | None | 0.47A | 3sueA-5wdxA:27.6 | 3sueA-5wdxA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6epi | ZETA_1 TOXIN (Neisseriagonorrhoeae) |
no annotation | 5 | GLY B 134ASP B 56ILE B 8SER B 86ALA B 82 | BNW B 501 (-3.5A)BNW B 501 (-3.2A)NoneBNW B 501 ( 3.8A)None | 1.05A | 3sueA-6epiB:undetectable | 3sueA-6epiB:16.04 |