SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUD_C_SUEC1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioo SF11-RNASE

(Nicotiana alata) 		PF00445
(Ribonuclease_T2) 		4 PHE A  29
TYR A 164
LEU A 111
LYS A 112
 None
None
None
NAG  A 197 (-2.9A)
 1.24A 3sudC-1iooA:
0.0		 3sudC-1iooA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksk TYPE-2 RESTRICTION
ENZYME PVUII

(Proteus hauseri) 		PF09225
(Endonuc-PvuII) 		4 PHE A  32
TYR A 264
LEU A  39
LYS A  38
 None
 1.46A 3sudC-3kskA:
0.0		 3sudC-3kskA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
PF17243
(POTRA_TamA_1) 		4 PHE A 429
TYR A 415
LEU A 499
LYS A 498
 None
 1.25A 3sudC-4c00A:
0.0		 3sudC-4c00A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 187
TYR A 350
LEU A 192
LYS A 191
 None
 1.21A 3sudC-4it1A:
0.0		 3sudC-4it1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		4 PHE A 429
TYR A 415
LEU A 499
LYS A 498
 None
 1.29A 3sudC-4n74A:
0.0		 3sudC-4n74A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w82 FATTY ACID SYNTHASE

(Homo sapiens) 		PF00107
(ADH_zinc_N) 		4 PHE A1603
TYR A1567
LEU A1599
LYS A1620
 None
 1.18A 3sudC-4w82A:
0.0		 3sudC-4w82A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 PHE A 110
TYR A 404
LEU A  89
LYS A  87
 None
None
EDO  A 505 (-4.4A)
None
 1.01A 3sudC-5e4rA:
0.0		 3sudC-5e4rA:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 PHE A1043
TYR A1056
LEU A1135
LYS A1136
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
 0.32A 3sudC-5eqqA:
34.6		 3sudC-5eqqA:
94.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ty7 PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		no annotation 4 PHE A 243
TYR A 239
LEU A 258
LYS A 259
 None
None
None
NFF  A 401 ( 4.8A)
 1.35A 3sudC-5ty7A:
0.0		 3sudC-5ty7A:
16.26