SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUD_C_SUEC1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aei ANNEXIN XII

(Hydra vulgaris) 		PF00191
(Annexin) 		5 ILE A 214
GLY A 183
ARG A 191
ALA A 176
ALA A 175
 None
 1.01A 3sudC-1aeiA:
undetectable		 3sudC-1aeiA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 GLY A  87
ASP A  90
ILE A  55
ALA A  36
ALA A  32
 None
 1.01A 3sudC-1ahiA:
undetectable		 3sudC-1ahiA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c1d L-PHENYLALANINE
DEHYDROGENASE

(Rhodococcus sp.) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 187
ILE A 315
GLY A 259
ALA A 260
ALA A 289
 None
None
None
NAI  A 360 (-3.7A)
None
 0.96A 3sudC-1c1dA:
undetectable		 3sudC-1c1dA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		9 GLN A  41
HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.57A 3sudC-1cu1A:
33.8		 3sudC-1cu1A:
80.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee6 PECTATE LYASE

(Bacillus sp.
KSM-P15) 		PF03211
(Pectate_lyase) 		5 ILE A 150
GLY A 128
ALA A 104
ALA A 101
ALA A 124
 None
 1.00A 3sudC-1ee6A:
undetectable		 3sudC-1ee6A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		5 ILE A 390
GLY A 397
ALA A 398
PHE A 399
ARG A 358
 None
 1.02A 3sudC-1j1wA:
undetectable		 3sudC-1j1wA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE

(Aspergillus
japonicus) 		no annotation 5 GLY A  45
ILE A 287
GLY A 305
ALA A 273
ALA A 275
 None
 0.92A 3sudC-1juhA:
undetectable		 3sudC-1juhA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		5 GLY A 195
ILE A  58
GLY A 204
ALA A 146
ALA A 145
 None
 0.94A 3sudC-1kfwA:
undetectable		 3sudC-1kfwA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aquifex
aeolicus) 		PF01791
(DeoC) 		6 GLY A 133
ASP A 103
ILE A 284
GLY A 306
ALA A 310
ALA A 290
 None
 1.26A 3sudC-1mzhA:
undetectable		 3sudC-1mzhA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 GLN A  41
HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
ALA A 156
ALA A 157
 None
 0.84A 3sudC-1ns3A:
29.7		 3sudC-1ns3A:
77.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		6 GLN A  41
HIS A  57
GLY A  58
ASP A  81
GLY A 137
ARG A 155
 None
 1.06A 3sudC-1ns3A:
29.7		 3sudC-1ns3A:
77.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.65A 3sudC-1ns3A:
29.7		 3sudC-1ns3A:
77.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0u BSTDEAD

(Geobacillus
stearothermophilus) 		PF00270
(DEAD) 		5 GLY A 166
ILE A 111
GLY A 135
ALA A  79
ALA A  85
 None
 0.96A 3sudC-1q0uA:
undetectable		 3sudC-1q0uA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 ILE A 212
GLY A 228
ARG A 202
ALA A 201
ALA A 209
 None
 1.02A 3sudC-1q51A:
undetectable		 3sudC-1q51A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 GLN A 483
ILE A 424
GLY A 479
ALA A 463
ALA A 453
 None
 1.03A 3sudC-1z68A:
undetectable		 3sudC-1z68A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B
CYTOCHROME C1

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02167
(Cytochrom_C1) 		5 ASP C 278
ILE D 131
GLY D 126
ALA D 106
ALA D 104
 None
HEC  D 501 ( 4.9A)
None
None
None
 0.99A 3sudC-1zrtC:
undetectable		 3sudC-1zrtC:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF01327
(Pep_deformylase) 		5 GLY A 145
GLY A 190
ALA A 105
ARG A 123
ALA A 120
 None
 0.90A 3sudC-1zy1A:
undetectable		 3sudC-1zy1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dua PHOSPHONOPYRUVATE
HYDROLASE

(Variovorax sp.
Pal2) 		PF13714
(PEP_mutase) 		5 ILE A  70
GLY A  38
ALA A  19
ALA A  21
ALA A  22
 None
 1.01A 3sudC-2duaA:
undetectable		 3sudC-2duaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgq OUTER MEMBRANE PORIN
PROTEIN 32

(Delftia
acidovorans) 		PF13609
(Porin_4) 		5 GLY X 131
ARG X 230
ILE X 162
GLY X 169
ALA X 195
 None
 1.02A 3sudC-2fgqX:
undetectable		 3sudC-2fgqX:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		5 GLY A 225
GLY A 267
PHE A 295
ALA A 273
ALA A 274
 PLP  A 400 (-3.5A)
None
None
None
None
 0.99A 3sudC-2isqA:
undetectable		 3sudC-2isqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j92 PICORNAIN 3C

(Foot-and-mouth
disease virus) 		PF00548
(Peptidase_C3) 		5 HIS A  46
ASP A  84
GLY A 161
ALA A 163
ALA A 183
 None
 0.77A 3sudC-2j92A:
9.8		 3sudC-2j92A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jax HYPOTHETICAL PROTEIN
TB31.7

(Mycobacterium
tuberculosis) 		PF00582
(Usp) 		5 GLY A 120
ILE A  72
GLY A  13
ALA A  20
ALA A  75
 ATP  A1296 (-3.2A)
None
ATP  A1296 (-3.3A)
ATP  A1296 (-2.6A)
None
 0.99A 3sudC-2jaxA:
undetectable		 3sudC-2jaxA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		6 GLN A  98
GLY A  35
ILE A  88
GLY A  38
ALA A  49
ALA A  47
 None
 1.38A 3sudC-2pozA:
undetectable		 3sudC-2pozA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B
CYTOCHROME C1

(Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02167
(Cytochrom_C1) 		6 ASP A 278
ILE B 131
GLY B 109
ALA B 108
ALA B 106
ALA B 104
 None
HEM  B 301 ( 4.3A)
None
None
None
None
 1.03A 3sudC-2qjpA:
undetectable		 3sudC-2qjpA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz4 PARAPLEGIN

(Homo sapiens) 		PF00004
(AAA) 		5 GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
 None
ADP  A 700 (-3.4A)
None
None
None
 0.96A 3sudC-2qz4A:
undetectable		 3sudC-2qz4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvd 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 GLY A  81
ASP A  84
ILE A  49
ALA A  29
ALA A  25
 None
 0.96A 3sudC-2uvdA:
undetectable		 3sudC-2uvdA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 GLY A  75
ARG A  50
ILE A  17
GLY A  10
ALA A  31
 None
 0.97A 3sudC-2vrcA:
undetectable		 3sudC-2vrcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqh IMMUNOGLOBULIN-BINDI
NG PROTEIN EIBD

(Escherichia
coli) 		PF05658
(YadA_head) 		5 GLY A 173
GLY A 201
ALA A 190
ALA A 192
ALA A 206
 None
 0.99A 3sudC-2xqhA:
undetectable		 3sudC-2xqhA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 GLY A 658
ILE A 652
GLY A 633
PHE A 667
ARG A 664
 None
 0.99A 3sudC-2xyuA:
undetectable		 3sudC-2xyuA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		5 GLN A 293
GLY A 286
ILE A 340
GLY A 335
ALA A 341
 SF4  A 373 ( 4.5A)
SF4  A 373 (-3.8A)
None
None
None
 0.96A 3sudC-3a05A:
undetectable		 3sudC-3a05A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a31 PROBABLE
THREONYL-TRNA
SYNTHETASE 1

(Aeropyrum
pernix) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		5 ASP A 466
ILE A 344
ALA A 364
ALA A 375
ALA A 342
 None
 0.98A 3sudC-3a31A:
undetectable		 3sudC-3a31A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		5 GLY A 271
ILE A  83
GLY A  12
ALA A  31
ALA A  32
 None
 1.02A 3sudC-3a5vA:
undetectable		 3sudC-3a5vA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		5 GLN A 606
GLY A 604
ILE A 655
ALA A 647
ALA A 646
 None
 1.00A 3sudC-3ai7A:
undetectable		 3sudC-3ai7A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3p METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF01596
(Methyltransf_3) 		5 GLY A 164
ASP A 132
ILE A 195
GLY A 199
ALA A 157
 None
 0.97A 3sudC-3c3pA:
undetectable		 3sudC-3c3pA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		5 GLN A  51
GLY A 122
ILE A 299
ALA A  26
ALA A 303
 NAP  A4005 (-3.7A)
NAP  A4005 (-3.4A)
None
NAP  A4005 (-3.6A)
None
 0.91A 3sudC-3f8rA:
undetectable		 3sudC-3f8rA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6s PUTATIVE
ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
FAMILY PROTEIN

(Bacteroides
vulgatus) 		PF03372
(Exo_endo_phos) 		5 GLN A  45
GLY A 171
ILE A  65
ALA A 134
ALA A 121
 None
 1.02A 3sudC-3g6sA:
undetectable		 3sudC-3g6sA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 GLY C 148
ILE C 207
GLY C 294
ALA C 290
ALA C  17
 None
 0.96A 3sudC-3gi8C:
undetectable		 3sudC-3gi8C:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3w PHOSPHOGLUCOSAMINE
MUTASE

(Francisella
tularensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		6 GLY A 338
ASP A 239
ILE A 202
ALA A 184
ALA A 180
ALA A 203
 None
ZN  A 900 (-2.3A)
None
None
None
None
 1.29A 3sudC-3i3wA:
undetectable		 3sudC-3i3wA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js4 SUPEROXIDE DISMUTASE

(Anaplasma
phagocytophilum) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 ASP A 150
ILE A  56
GLY A  67
ALA A  75
ALA A  74
 None
 1.01A 3sudC-3js4A:
undetectable		 3sudC-3js4A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 GLN A 163
GLY A 162
ALA A  63
ARG A  65
ALA A  95
 None
 0.97A 3sudC-3l6cA:
undetectable		 3sudC-3l6cA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o03 DEHYDROGENASE WITH
DIFFERENT
SPECIFICITIES

(Streptococcus
suis) 		PF13561
(adh_short_C2) 		5 GLY A  90
ASP A  93
ILE A  63
ALA A  39
ALA A  35
 None
 0.98A 3sudC-3o03A:
undetectable		 3sudC-3o03A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr4 DNA POLYMERASE IV

(Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		5 GLY A 162
ARG A 119
ILE A 111
GLY A 143
ALA A 121
 None
 0.99A 3sudC-3pr4A:
undetectable		 3sudC-3pr4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		5 HIS A  63
ILE A 191
GLY A 201
ALA A 160
ALA A 174
 None
 0.95A 3sudC-3q9cA:
undetectable		 3sudC-3q9cA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 461
ILE A 515
GLY A 547
ALA A 478
ALA A 479
 None
 0.83A 3sudC-3rimA:
undetectable		 3sudC-3rimA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.85A 3sudC-3s29A:
undetectable		 3sudC-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  22
GLY A  50
ALA A  39
ALA A  41
ALA A  55
 None
 1.00A 3sudC-3s6lA:
undetectable		 3sudC-3s6lA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  64
GLY A  92
ALA A  81
ALA A  83
ALA A  97
 None
 0.89A 3sudC-3s6lA:
undetectable		 3sudC-3s6lA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  78
GLY A 106
ALA A  95
ALA A  97
ALA A 111
 None
 0.99A 3sudC-3s6lA:
undetectable		 3sudC-3s6lA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 ASP A 246
GLY A 193
ALA A 195
PHE A 181
ALA A 183
 None
 1.00A 3sudC-3tbhA:
undetectable		 3sudC-3tbhA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2g 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 GLY A 108
ASP A 111
ILE A  76
ALA A  56
ALA A  52
 None
 0.97A 3sudC-3v2gA:
undetectable		 3sudC-3v2gA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdq BETA-MANNANASE

(Symbiotic
protist of
Reticulitermes
speratus) 		PF02156
(Glyco_hydro_26) 		5 GLY A 203
ILE A 237
GLY A 194
ALA A 192
ALA A 233
 None
NA  A 403 (-4.6A)
None
None
None
 0.91A 3sudC-3wdqA:
undetectable		 3sudC-3wdqA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wtb PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF13561
(adh_short_C2) 		5 ARG A   4
ILE A   8
ALA A 123
ALA A  84
ALA A   6
 None
 1.01A 3sudC-3wtbA:
undetectable		 3sudC-3wtbA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuf ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
sp.) 		PF00331
(Glyco_hydro_10) 		5 GLN A  78
ASP A 162
GLY A 307
ALA A 268
ALA A 242
 None
 1.00A 3sudC-3wufA:
undetectable		 3sudC-3wufA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfv CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 1

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		5 ARG A 255
ILE A 244
GLY A 174
ALA A 178
ALA A 253
 None
 0.98A 3sudC-3zfvA:
undetectable		 3sudC-3zfvA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 GLY A  22
ILE A  10
GLY A  29
ALA A  27
ALA A  13
 None
 1.02A 3sudC-4a1oA:
undetectable		 3sudC-4a1oA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2i PUTATIVE RIBOSOME
BIOGENESIS GTPASE
RSGA

(Salmonella
enterica) 		PF03193
(RsgA_GTPase) 		5 GLY V 282
ARG V 216
ILE V 165
GLY V 222
ALA V 221
 None
 0.89A 3sudC-4a2iV:
undetectable		 3sudC-4a2iV:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3v E1 ENVELOPE
GLYCOPROTEIN

(Rubella virus) 		PF05748
(Rubella_E1) 		5 GLY A 288
ILE A  74
ALA A  48
PHE A 142
ALA A 143
 None
 1.02A 3sudC-4b3vA:
undetectable		 3sudC-4b3vA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		5 GLY A 595
ILE A 570
ALA A 528
ALA A 526
ALA A 525
 None
 0.98A 3sudC-4ccdA:
undetectable		 3sudC-4ccdA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dt5 ANTIFREEZE PROTEIN

(Rhagium
inquisitor) 		no annotation 5 GLY A  27
GLY A  69
ALA A  51
ALA A  53
ALA A  73
 None
 0.95A 3sudC-4dt5A:
undetectable		 3sudC-4dt5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		6 GLY W 592
ARG W 458
ILE W 575
ALA W 590
ARG W 460
ALA W 343
 None
 1.25A 3sudC-4f5xW:
undetectable		 3sudC-4f5xW:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		5 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.92A 3sudC-4fx5A:
undetectable		 3sudC-4fx5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 GLY A 449
ILE A 176
GLY A 171
ARG A 335
ALA A 337
 None
 0.87A 3sudC-4ga4A:
undetectable		 3sudC-4ga4A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 GLY A 449
ILE A 176
GLY A 171
ARG A 335
ALA A 337
 None
 0.93A 3sudC-4ga6A:
undetectable		 3sudC-4ga6A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF00106
(adh_short) 		5 GLY A  98
ASP A 101
ILE A  67
ALA A  47
ALA A  43
 None
 0.95A 3sudC-4kzpA:
undetectable		 3sudC-4kzpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		5 HIS A 255
ASP A 227
ILE A 102
GLY A  33
ALA A 105
 22J  A 301 ( 4.5A)
None
None
22J  A 301 (-3.4A)
22J  A 301 (-2.8A)
 0.98A 3sudC-4lxiA:
undetectable		 3sudC-4lxiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN

(Bordetella
pertussis) 		PF13458
(Peripla_BP_6) 		5 GLN A 105
ILE A 151
GLY A 210
ALA A 232
ALA A 207
 None
 1.00A 3sudC-4mptA:
undetectable		 3sudC-4mptA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		5 GLN A 292
GLY A 289
ASP A  95
ILE A 149
ALA A 150
 None
UDP  A 401 (-3.7A)
UD1  A 400 ( 4.8A)
None
None
 0.92A 3sudC-4nesA:
undetectable		 3sudC-4nesA:
18.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 ARG A 123
ILE A 132
GLY A 137
PHE A 154
ALA A 157
 None
2R8  A 301 (-4.3A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.8A)
 0.94A 3sudC-4nwkA:
35.5		 3sudC-4nwkA:
98.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		10 GLN A  41
HIS A  57
GLY A  58
ASP A  81
ILE A 132
GLY A 137
PHE A 154
ARG A 155
ALA A 156
ALA A 157
 2R8  A 301 ( 3.5A)
2R8  A 301 (-3.3A)
2R8  A 301 (-3.5A)
2R8  A 301 (-3.6A)
2R8  A 301 (-4.3A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.6A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
 0.61A 3sudC-4nwkA:
35.5		 3sudC-4nwkA:
98.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 273
GLY A 274
ASP A 404
GLY A 288
ALA A 426
 None
 0.89A 3sudC-4rbnA:
undetectable		 3sudC-4rbnA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		5 GLY A  82
ASP A  85
ILE A  50
ALA A  31
ALA A  27
 None
 1.01A 3sudC-4trrA:
undetectable		 3sudC-4trrA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trt DNA POLYMERASE III
SUBUNIT BETA

(Deinococcus
radiodurans) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 GLY A 352
ARG A 174
ILE A 156
ALA A 176
ALA A 169
 None
 0.94A 3sudC-4trtA:
undetectable		 3sudC-4trtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 HIS A 311
GLY A 309
ILE A 284
GLY A 306
ALA A 282
 None
 0.96A 3sudC-4woeA:
undetectable		 3sudC-4woeA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy9 PUTATIVE MCP-TYPE
SIGNAL TRANSDUCTION
PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		5 GLN A 232
GLY A 236
ALA A 315
ALA A 297
ALA A 298
 None
 0.91A 3sudC-4wy9A:
undetectable		 3sudC-4wy9A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus) 		PF05416
(Peptidase_C37) 		6 HIS A  30
ASP A  54
GLY A 137
ALA A 139
ALA A 159
ALA A 160
 None
 0.65A 3sudC-4x2xA:
9.8		 3sudC-4x2xA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A  81
ASP A 111
GLY A 188
ALA A 190
ALA A 207
 None
 0.28A 3sudC-4ynnA:
12.6		 3sudC-4ynnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 HIS A 279
GLY A 280
ILE A 285
GLY A 271
ALA A 211
 None
 0.96A 3sudC-5a4jA:
undetectable		 3sudC-5a4jA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abj VP2

(Enterovirus A) 		PF00073
(Rhv) 		5 ARG B 103
GLY B  93
ALA B  96
PHE B 245
ALA B 243
 None
 0.97A 3sudC-5abjB:
undetectable		 3sudC-5abjB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 181
ILE A 310
GLY A 254
ALA A 255
ALA A 285
 None
 1.01A 3sudC-5b37A:
undetectable		 3sudC-5b37A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bra PUTATIVE PERIPLASMIC
BINDING PROTEIN WITH
SUBSTRATE RIBOSE

(Ochrobactrum
anthropi) 		PF13407
(Peripla_BP_4) 		5 GLN A 180
GLY A 173
ILE A 278
GLY A 233
ALA A 240
 None
 0.97A 3sudC-5braA:
undetectable		 3sudC-5braA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLN A 355
GLY A  12
GLY A   9
ALA A 101
PHE A 102
 None
 0.92A 3sudC-5e6kA:
undetectable		 3sudC-5e6kA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLN A 355
GLY A  12
GLY A   9
ALA A 101
PHE A 102
 None
 0.91A 3sudC-5enyA:
undetectable		 3sudC-5enyA:
13.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		12 GLN A1041
HIS A1057
GLY A1058
ASP A1081
ARG A1123
ILE A1132
GLY A1137
ALA A1139
PHE A1154
ARG A1155
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.4A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.65A 3sudC-5eqqA:
34.6		 3sudC-5eqqA:
94.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A  39
GLY A 273
ALA A 753
ALA A 240
ALA A 237
 None
 0.81A 3sudC-5fjjA:
undetectable		 3sudC-5fjjA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 5 GLY A 143
ARG A 259
GLY A 186
ALA A 184
ALA A 204
 None
 0.99A 3sudC-5fzpA:
undetectable		 3sudC-5fzpA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gju ATP-DEPENDENT RNA
HELICASE DEAD

(Escherichia
coli) 		PF00270
(DEAD) 		5 GLY A 152
ILE A  37
ALA A 184
PHE A 186
ALA A  59
 None
 0.98A 3sudC-5gjuA:
undetectable		 3sudC-5gjuA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		5 GLY A  69
ILE A 170
GLY A 117
ALA A 115
ALA A 233
 None
 0.92A 3sudC-5h6sA:
undetectable		 3sudC-5h6sA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm2 3C PROTEINASE

(Foot-and-mouth
disease virus) 		PF00548
(Peptidase_C3) 		5 HIS A  46
ASP A  84
GLY A 161
ALA A 163
ALA A 183
 None
 0.89A 3sudC-5hm2A:
0.4		 3sudC-5hm2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 533
ASP A 500
ARG A 497
ILE A 556
ALA A 558
 None
 0.99A 3sudC-5i51A:
undetectable		 3sudC-5i51A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		5 GLN A 277
GLY A 147
ILE A 195
ALA A 208
ALA A 207
 BEZ  A 401 (-3.9A)
None
None
None
None
 0.84A 3sudC-5im2A:
undetectable		 3sudC-5im2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus) 		PF00291
(PALP) 		5 ASP A 249
GLY A 190
ALA A 192
PHE A 178
ALA A 180
 None
 0.89A 3sudC-5jjcA:
undetectable		 3sudC-5jjcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 5 GLY A 115
ASP A 274
GLY A 141
ALA A 278
ALA A 161
 None
 0.93A 3sudC-5mg5A:
undetectable		 3sudC-5mg5A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsq IUNH

(Leishmania
braziliensis) 		PF01156
(IU_nuc_hydro) 		6 ASP A 172
ARG A 137
ILE A 109
GLY A  66
ALA A 133
ALA A 135
 None
 1.34A 3sudC-5tsqA:
undetectable		 3sudC-5tsqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN

(Squalimorphii) 		PF00566
(RabGAP-TBC) 		5 GLN A 579
GLY A 649
ARG A 328
ILE A 585
ALA A 627
 None
 1.01A 3sudC-5tubA:
undetectable		 3sudC-5tubA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgb ANTI-CRISPR PROTEIN
(ACRIIC1)

(Neisseria
meningitidis) 		no annotation 5 GLY B  15
ILE B  29
GLY B  12
ALA B  21
ALA B  22
 None
 1.02A 3sudC-5vgbB:
undetectable		 3sudC-5vgbB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8p HOMOSERINE
O-ACETYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF00561
(Abhydrolase_1) 		5 GLY A 163
ARG A 238
GLY A 322
ALA A 184
ALA A 359
 None
 0.86A 3sudC-5w8pA:
undetectable		 3sudC-5w8pA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 7 GLN A  41
GLY A  58
ARG A 123
PHE A 154
ARG A 155
ALA A 156
ALA A 157
 None
 1.02A 3sudC-5wdxA:
26.7		 3sudC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 9 GLN A  41
HIS A  57
GLY A  58
ARG A 123
ILE A 132
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.70A 3sudC-5wdxA:
26.7		 3sudC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 7 GLY A  58
ASP A  81
ARG A 123
PHE A 154
ARG A 155
ALA A 156
ALA A 157
 None
 0.96A 3sudC-5wdxA:
26.7		 3sudC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 9 HIS A  57
GLY A  58
ASP A  81
ARG A 123
ILE A 132
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.58A 3sudC-5wdxA:
26.7		 3sudC-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioo SF11-RNASE

(Nicotiana alata) 		PF00445
(Ribonuclease_T2) 		4 PHE A  29
TYR A 164
LEU A 111
LYS A 112
 None
None
None
NAG  A 197 (-2.9A)
 1.24A 3sudC-1iooA:
0.0		 3sudC-1iooA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksk TYPE-2 RESTRICTION
ENZYME PVUII

(Proteus hauseri) 		PF09225
(Endonuc-PvuII) 		4 PHE A  32
TYR A 264
LEU A  39
LYS A  38
 None
 1.46A 3sudC-3kskA:
0.0		 3sudC-3kskA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
PF17243
(POTRA_TamA_1) 		4 PHE A 429
TYR A 415
LEU A 499
LYS A 498
 None
 1.25A 3sudC-4c00A:
0.0		 3sudC-4c00A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A 187
TYR A 350
LEU A 192
LYS A 191
 None
 1.21A 3sudC-4it1A:
0.0		 3sudC-4it1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n74 PREDICTED OUTER
MEMBRANE PROTEIN AND
SURFACE ANTIGEN

(Escherichia
coli) 		PF01103
(Bac_surface_Ag) 		4 PHE A 429
TYR A 415
LEU A 499
LYS A 498
 None
 1.29A 3sudC-4n74A:
0.0		 3sudC-4n74A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w82 FATTY ACID SYNTHASE

(Homo sapiens) 		PF00107
(ADH_zinc_N) 		4 PHE A1603
TYR A1567
LEU A1599
LYS A1620
 None
 1.18A 3sudC-4w82A:
0.0		 3sudC-4w82A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 PHE A 110
TYR A 404
LEU A  89
LYS A  87
 None
None
EDO  A 505 (-4.4A)
None
 1.01A 3sudC-5e4rA:
0.0		 3sudC-5e4rA:
17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 PHE A1043
TYR A1056
LEU A1135
LYS A1136
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
 0.32A 3sudC-5eqqA:
34.6		 3sudC-5eqqA:
94.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ty7 PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		no annotation 4 PHE A 243
TYR A 239
LEU A 258
LYS A 259
 None
None
None
NFF  A 401 ( 4.8A)
 1.35A 3sudC-5ty7A:
0.0		 3sudC-5ty7A:
16.26