SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUD_B_SUEB1201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ag9 FLAVODOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		5 TYR A  58
GLY A  60
ILE A 108
GLY A 103
ALA A 101
 None
FMN  A 177 (-3.8A)
None
None
None
 1.04A 3sudB-1ag9A:
undetectable		 3sudB-1ag9A:
19.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		9 GLN A  41
PHE A  43
TYR A  56
HIS A  57
GLY A  58
ASP A  81
GLY A 137
PHE A 154
ALA A 156
 None
 0.49A 3sudB-1cu1A:
34.9		 3sudB-1cu1A:
80.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		5 ASP E 138
ILE E  73
GLY E  34
ALA E 124
ALA E 129
 None
 1.02A 3sudB-1cziE:
undetectable		 3sudB-1cziE:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Lactobacillus
casei) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 HIS A 204
GLY A 157
ASP A 202
ALA A 106
SER A 293
 None
 1.06A 3sudB-1dxyA:
undetectable		 3sudB-1dxyA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.13A 3sudB-1efpA:
undetectable		 3sudB-1efpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.09A 3sudB-1efvA:
undetectable		 3sudB-1efvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Cyberlindnera
saturnus) 		PF00291
(PALP) 		5 GLN A 237
GLY A 139
ILE A  58
GLY A 164
ALA A 163
 None
 1.13A 3sudB-1f2dA:
undetectable		 3sudB-1f2dA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		5 PHE A  60
GLY A  89
GLY A  64
ALA A  65
ALA A  81
 None
 1.12A 3sudB-1gynA:
undetectable		 3sudB-1gynA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hix ENDO-1,4-BETA-XYLANA
SE

(Streptomyces
sp. S38) 		PF00457
(Glyco_hydro_11) 		5 GLY A  10
ILE A 187
GLY A  52
ALA A  49
SER A 185
 None
 1.04A 3sudB-1hixA:
undetectable		 3sudB-1hixA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		5 GLY A 321
ILE A 401
GLY A 406
ALA A 683
SER A 678
 None
 0.92A 3sudB-1i6qA:
undetectable		 3sudB-1i6qA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6y PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Arabidopsis
thaliana) 		PF00639
(Rotamase) 		5 ILE A 116
GLY A  77
ALA A  64
PHE A  60
SER A 104
 None
 1.10A 3sudB-1j6yA:
undetectable		 3sudB-1j6yA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		5 TYR A 398
GLY A 280
ILE A 240
GLY A 352
ALA A 376
 None
 1.05A 3sudB-1jneA:
undetectable		 3sudB-1jneA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE

(Aspergillus
japonicus) 		no annotation 5 GLY A  45
ILE A 287
GLY A 305
ALA A 273
ALA A 275
 None
 0.80A 3sudB-1juhA:
undetectable		 3sudB-1juhA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kob TWITCHIN

(Aplysia
californica) 		PF00069
(Pkinase) 		5 PHE A 195
ASP A 232
ILE A 364
GLY A 196
ALA A 198
 None
 1.08A 3sudB-1kobA:
undetectable		 3sudB-1kobA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 GLY A  19
ILE A 214
GLY A 240
ALA A 259
ALA A 257
 None
 1.04A 3sudB-1nr0A:
undetectable		 3sudB-1nr0A:
14.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		9 GLN A  41
PHE A  43
TYR A  56
HIS A  57
GLY A  58
ASP A  81
GLY A 137
PHE A 154
ALA A 156
 None
 0.70A 3sudB-1ns3A:
18.3		 3sudB-1ns3A:
77.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 HIS A  68
GLY A  67
ILE A 275
GLY A  47
SER A 299
 ZN  A1502 (-3.5A)
None
None
None
None
 1.01A 3sudB-1q1nA:
undetectable		 3sudB-1q1nA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdb CYTOCHROME C NITRITE
REDUCTASE

(Sulfurospirillum
deleyianum) 		PF02335
(Cytochrom_C552) 		6 GLN A 396
PHE A 362
TYR A  95
GLY A 366
ALA A  81
ALA A 457
 None
None
HEM  A 515 (-4.7A)
None
None
None
 1.31A 3sudB-1qdbA:
undetectable		 3sudB-1qdbA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrm LACTALDEHYDE
REDUCTASE

(Escherichia
coli) 		PF00465
(Fe-ADH) 		5 PHE A 254
TYR A 248
GLY A 251
GLY A 204
ALA A 201
 PGO  A 390 (-4.8A)
None
None
None
None
 1.10A 3sudB-1rrmA:
undetectable		 3sudB-1rrmA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		5 TYR A 199
ASP A 179
GLY A 193
ALA A 183
SER A 186
 None
 0.96A 3sudB-1wd3A:
undetectable		 3sudB-1wd3A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		5 GLN B 109
GLY B 298
ILE B 341
ALA B 347
SER B 335
 PLP  B 400 (-3.4A)
PLP  B 400 (-3.8A)
None
None
None
 1.13A 3sudB-1wdwB:
undetectable		 3sudB-1wdwB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		5 GLN B 109
GLY B 298
ILE B 341
GLY B 372
ALA B 347
 PLP  B 400 (-3.4A)
PLP  B 400 (-3.8A)
None
PLP  B 400 (-3.4A)
None
 0.99A 3sudB-1wdwB:
undetectable		 3sudB-1wdwB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		5 GLY B  88
ILE B 127
GLY B 118
ALA B 117
ALA B 113
 None
 1.05A 3sudB-1wdwB:
undetectable		 3sudB-1wdwB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		5 HIS A 271
ASP A 244
GLY A  36
ALA A 105
SER A  47
 LEU  A 301 (-3.4A)
None
LEU  A 301 (-3.2A)
PHE  A 300 ( 3.0A)
None
 0.91A 3sudB-1xqwA:
undetectable		 3sudB-1xqwA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		5 PHE A 181
ILE A 259
GLY A 182
ALA A 228
ALA A 169
 None
 1.10A 3sudB-1yp4A:
undetectable		 3sudB-1yp4A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		5 TYR A 297
HIS A 248
GLY A 247
ILE A  50
GLY A 242
 None
None
None
None
5GP  A1340 (-3.6A)
 1.06A 3sudB-2bwgA:
undetectable		 3sudB-2bwgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e80 CYTOCHROME C-552

(Wolinella
succinogenes) 		PF02335
(Cytochrom_C552) 		6 GLN A 390
PHE A 356
TYR A  96
GLY A 360
ALA A  82
ALA A 451
 None
None
HEM  A1508 (-4.6A)
None
None
None
 1.34A 3sudB-2e80A:
undetectable		 3sudB-2e80A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 PHE A 153
GLY A 128
GLY A 152
ALA A 154
PHE A 168
 None
 1.03A 3sudB-2ecfA:
undetectable		 3sudB-2ecfA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		5 GLY A 870
GLY A 552
ALA A 815
PHE A 816
ALA A 843
 None
 1.11A 3sudB-2hg4A:
undetectable		 3sudB-2hg4A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j66 BTRK

(Bacillus
circulans) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 GLY A  92
ALA A  70
PHE A  90
ALA A  72
SER A  98
 None
 1.12A 3sudB-2j66A:
undetectable		 3sudB-2j66A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j92 PICORNAIN 3C

(Foot-and-mouth
disease virus) 		PF00548
(Peptidase_C3) 		5 HIS A  46
ASP A  84
GLY A 161
ALA A 163
ALA A 183
 None
 0.64A 3sudB-2j92A:
10.3		 3sudB-2j92A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p18 GLYOXALASE II

(Leishmania
infantum) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 HIS A 210
GLY A 209
ASP A  80
GLY A 172
PHE A 175
 ZN  A 301 ( 3.3A)
None
ZN  A 301 ( 2.7A)
SPD  A 304 ( 4.2A)
ACY  A1022 (-4.9A)
 1.13A 3sudB-2p18A:
undetectable		 3sudB-2p18A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po3 4-DEHYDRASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		5 PHE A1196
GLY A1208
GLY A1252
ALA A1204
PHE A1205
 None
 1.13A 3sudB-2po3A:
undetectable		 3sudB-2po3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi9 VITAMIN B12 IMPORT
SYSTEM PERMEASE
PROTEIN BTUC

(Escherichia
coli) 		PF01032
(FecCD) 		5 GLY A  67
ILE A 263
GLY A 257
ALA A  71
SER A 267
 None
 1.12A 3sudB-2qi9A:
undetectable		 3sudB-2qi9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		6 GLN A 418
TYR A 510
GLY A 410
GLY A 386
ALA A 408
SER A 332
 None
None
None
None
AD0  A1617 ( 3.8A)
None
 1.42A 3sudB-2uvfA:
undetectable		 3sudB-2uvfA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 GLY A 181
ILE A 236
GLY A  73
ALA A  72
ALA A 194
 None
 1.07A 3sudB-2vosA:
undetectable		 3sudB-2vosA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF01276
(OKR_DC_1)
PF03711
(OKR_DC_1_C) 		5 PHE A 260
GLY A  32
ALA A 257
ALA A 252
SER A 247
 None
 1.14A 3sudB-2x3lA:
undetectable		 3sudB-2x3lA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfs ORF12

(Streptomyces
clavuligerus) 		PF13354
(Beta-lactamase2) 		5 GLN A 408
GLY A 381
ASP A 325
GLY A 316
SER A 206
 None
 1.13A 3sudB-2xfsA:
undetectable		 3sudB-2xfsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bry TBUX

(Ralstonia
pickettii) 		PF03349
(Toluene_X) 		5 ASP A  51
GLY A 382
ALA A 397
PHE A 396
ALA A 427
 None
 1.11A 3sudB-3bryA:
undetectable		 3sudB-3bryA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 HIS A 806
GLY A 811
GLY A 799
ALA A 847
SER A 550
 None
 1.12A 3sudB-3c10A:
undetectable		 3sudB-3c10A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3p METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF01596
(Methyltransf_3) 		5 GLY A 164
ASP A 132
ILE A 195
GLY A 199
ALA A 157
 None
 0.94A 3sudB-3c3pA:
undetectable		 3sudB-3c3pA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 GLN A  81
PHE A  56
GLY A  58
GLY A  55
ALA A  51
 None
 0.87A 3sudB-3ctzA:
undetectable		 3sudB-3ctzA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Staphylococcus
aureus) 		PF00342
(PGI) 		5 GLN A 313
GLY A 371
GLY A 315
PHE A 318
SER A 297
 None
 1.08A 3sudB-3ff1A:
undetectable		 3sudB-3ff1A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go4 PROTEIN OF UNKNOWN
FUNCTION DUF574

(Streptomyces
avermitilis) 		PF04672
(Methyltransf_19) 		5 TYR A  29
ILE A 166
GLY A  87
ALA A  24
SER A 198
 None
SAH  A 277 (-3.8A)
SAH  A 277 (-3.1A)
SAH  A 277 (-3.1A)
None
 1.13A 3sudB-3go4A:
undetectable		 3sudB-3go4A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		5 GLN A  64
GLY A 265
ILE A 437
ALA A 352
ALA A 356
 None
 1.11A 3sudB-3i5tA:
undetectable		 3sudB-3i5tA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktc XYLOSE ISOMERASE

(Pectobacterium
atrosepticum) 		PF01261
(AP_endonuc_2) 		5 GLY A 209
ILE A 251
GLY A 203
ALA A 205
ALA A 213
 None
 1.09A 3sudB-3ktcA:
undetectable		 3sudB-3ktcA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llq AQUAPORIN Z 2

(Agrobacterium
fabrum) 		PF00230
(MIP) 		5 GLY A  18
ILE A 171
GLY A  44
ALA A  42
SER A 175
 None
 1.09A 3sudB-3llqA:
undetectable		 3sudB-3llqA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 GLY A 603
ILE A 665
GLY A 600
ALA A 597
ALA A 595
 None
 1.09A 3sudB-3mi6A:
undetectable		 3sudB-3mi6A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 TYR A 172
HIS A 173
ASP A 203
GLY A 280
ALA A 299
 None
 0.42A 3sudB-3qo6A:
12.9		 3sudB-3qo6A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 GLY A 741
ILE A 665
GLY A 668
ALA A 721
ALA A 723
 None
 1.07A 3sudB-3szeA:
8.2		 3sudB-3szeA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3v E1 ENVELOPE
GLYCOPROTEIN

(Rubella virus) 		PF05748
(Rubella_E1) 		5 GLY A 288
ILE A  74
ALA A  48
PHE A 142
ALA A 143
 None
 1.01A 3sudB-4b3vA:
undetectable		 3sudB-4b3vA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5x 4-HYDROXY-2-OXO-HEPT
ANE-1,7-DIOATE
ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		5 GLY A 206
ILE A 171
GLY A 168
ALA A 208
ALA A 227
 None
 1.13A 3sudB-4b5xA:
undetectable		 3sudB-4b5xA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00043
(GST_C) 		5 GLY A  24
ILE A  30
GLY A  20
ALA A  22
PHE A  69
 None
 1.04A 3sudB-4bvxA:
undetectable		 3sudB-4bvxA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		5 GLN A 319
ASP A 228
GLY A 284
ALA A 232
SER A 237
 SO4  A1410 ( 4.6A)
SO4  A1410 ( 4.1A)
None
None
None
 1.05A 3sudB-4c2lA:
undetectable		 3sudB-4c2lA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fio METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanobrevibacter
ruminantium) 		PF02289
(MCH) 		5 GLY A 184
GLY A 236
ALA A 212
ALA A 215
SER A 317
 None
 1.05A 3sudB-4fioA:
undetectable		 3sudB-4fioA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		5 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.91A 3sudB-4fx5A:
undetectable		 3sudB-4fx5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h09 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Eubacterium
ventriosum) 		PF13306
(LRR_5) 		5 GLY A 137
ILE A  88
GLY A  92
ALA A 118
PHE A  96
 PEG  A 501 ( 4.0A)
None
None
None
None
 1.12A 3sudB-4h09A:
undetectable		 3sudB-4h09A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		5 PHE A  93
GLY A 226
ALA A 227
ALA A 187
SER A  35
 None
 1.09A 3sudB-4iw7A:
undetectable		 3sudB-4iw7A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLN A 266
HIS A 290
GLY A 268
GLY A 250
ALA A 281
 FAD  A 401 (-4.1A)
FAD  A 401 (-3.9A)
FAD  A 401 (-3.3A)
None
None
 1.09A 3sudB-4kpuA:
undetectable		 3sudB-4kpuA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		5 HIS A 255
ASP A 227
ILE A 102
GLY A  33
ALA A 105
 22J  A 301 ( 4.5A)
None
None
22J  A 301 (-3.4A)
22J  A 301 (-2.8A)
 1.11A 3sudB-4lxiA:
undetectable		 3sudB-4lxiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		5 HIS A 255
ASP A 227
ILE A 102
GLY A 107
ALA A 105
 22J  A 301 ( 4.5A)
None
None
None
22J  A 301 (-2.8A)
 0.91A 3sudB-4lxiA:
undetectable		 3sudB-4lxiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nt4 GILGAMESH, ISOFORM I

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 PHE A 192
ASP A 237
GLY A 193
ALA A 195
SER A 214
 None
 1.10A 3sudB-4nt4A:
undetectable		 3sudB-4nt4A:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		10 GLN A  41
PHE A  43
TYR A  56
HIS A  57
GLY A  58
ASP A  81
ILE A 132
GLY A 137
PHE A 154
ALA A 156
 2R8  A 301 ( 3.5A)
2R8  A 301 (-4.6A)
None
2R8  A 301 (-3.3A)
2R8  A 301 (-3.5A)
2R8  A 301 (-3.6A)
2R8  A 301 (-4.3A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.1A)
 0.50A 3sudB-4nwkA:
35.6		 3sudB-4nwkA:
98.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6p CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF17033
(Peptidase_M99)
PF17129
(Peptidase_M99_C)
PF17130
(Peptidase_M99_m) 		5 HIS A 236
GLY A  51
ILE A 153
GLY A 130
ALA A 223
 None
 1.10A 3sudB-4q6pA:
undetectable		 3sudB-4q6pA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 TYR A 150
GLY A 355
ILE A 184
ALA A 407
ALA A 403
 LLP  A 353 (-3.8A)
LLP  A 353 ( 4.1A)
None
None
None
 1.02A 3sudB-4q6rA:
undetectable		 3sudB-4q6rA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rus FISH-EGG LECTIN

(Cyprinus carpio) 		PF06462
(Hyd_WA) 		5 GLN A  80
GLY A  91
GLY A  56
ALA A  52
SER A  17
 None
 1.11A 3sudB-4rusA:
undetectable		 3sudB-4rusA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wi0 CELLULOSOMAL
SCAFFOLDIN
CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin)
PF13620
(CarboxypepD_reg) 		5 TYR A 149
GLY A 150
ALA B 174
PHE B 177
ALA A  97
 None
 0.99A 3sudB-4wi0A:
undetectable		 3sudB-4wi0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 HIS A  30
ASP A  54
GLY A 137
ALA A 139
ALA A 159
 None
 0.59A 3sudB-4x2xA:
10.2		 3sudB-4x2xA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp. BTAi1) 		PF13407
(Peripla_BP_4) 		5 PHE A 206
TYR A 173
GLY A 205
ALA A 209
SER A  43
 None
 1.10A 3sudB-4yhsA:
undetectable		 3sudB-4yhsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A  81
ASP A 111
GLY A 188
ALA A 190
ALA A 207
 None
 0.23A 3sudB-4ynnA:
13.1		 3sudB-4ynnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxt POLYKETIDE
BIOSYNTHESIS
3-HYDROXY-3-METHYLGL
UTARYL-ACP SYNTHASE
PKSG

(Bacillus
subtilis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 PHE A  54
GLY A  14
ILE A  62
GLY A  55
ALA A 172
 None
 0.98A 3sudB-4yxtA:
undetectable		 3sudB-4yxtA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9x GLUCONATE
5-DEHYDROGENASE

(Streptococcus
pyogenes) 		PF13561
(adh_short_C2) 		5 TYR A  19
GLY A  22
ILE A  11
ALA A  26
ALA A  60
 None
 1.08A 3sudB-4z9xA:
undetectable		 3sudB-4z9xA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd6 HALOHYDRIN EPOXIDASE
B

(Corynebacterium
sp.) 		PF13561
(adh_short_C2) 		5 GLN A 138
PHE A 158
GLY A 117
ASP A 199
ALA A 203
 None
 1.12A 3sudB-4zd6A:
undetectable		 3sudB-4zd6A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT
PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 GLN C 147
TYR A 654
GLY A 609
ALA A 607
ALA A 603
 None
PEG  A 804 (-4.5A)
None
None
MCN  A 801 ( 3.9A)
 1.10A 3sudB-4zohC:
undetectable		 3sudB-4zohC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		5 GLY A 524
ASP A 521
ILE A 561
GLY A 490
ALA A 529
 None
 1.03A 3sudB-5az4A:
undetectable		 3sudB-5az4A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b69 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Thermoplasma
acidophilum) 		PF01884
(PcrB) 		5 ILE A 244
GLY A 217
ALA A 216
ALA A 212
SER A 243
 None
 1.04A 3sudB-5b69A:
undetectable		 3sudB-5b69A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		5 ILE A  72
GLY A 336
ALA A 247
PHE A 248
ALA A 231
 None
None
ACT  A 402 ( 3.8A)
None
None
 1.02A 3sudB-5cadA:
undetectable		 3sudB-5cadA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej3 ENDO-1,4-BETA-XYLANA
SE B

(Streptomyces
lividans) 		PF00457
(Glyco_hydro_11) 		5 GLY A  10
ILE A 187
GLY A  52
ALA A  49
SER A 185
 None
 1.11A 3sudB-5ej3A:
undetectable		 3sudB-5ej3A:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		11 GLN A1041
PHE A1043
TYR A1056
HIS A1057
GLY A1058
ASP A1081
ILE A1132
GLY A1137
ALA A1139
PHE A1154
ALA A1156
 5RS  A1203 (-2.9A)
5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.4A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
 0.35A 3sudB-5eqqA:
35.8		 3sudB-5eqqA:
94.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eve PROFILIN

(Ambrosia
artemisiifolia) 		PF00235
(Profilin) 		5 TYR A   6
ILE A  52
GLY A 106
ALA A  25
PHE A  41
 None
 1.08A 3sudB-5eveA:
undetectable		 3sudB-5eveA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm2 3C PROTEINASE

(Foot-and-mouth
disease virus) 		PF00548
(Peptidase_C3) 		5 HIS A  46
ASP A  84
GLY A 161
ALA A 163
ALA A 183
 None
 0.81A 3sudB-5hm2A:
10.0		 3sudB-5hm2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 TYR A 636
GLY A 641
ASP A 632
ILE A 568
PHE A 583
 None
 1.03A 3sudB-5hp5A:
undetectable		 3sudB-5hp5A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 TYR A  12
GLY A 171
GLY A 299
ALA A 300
PHE A 303
 None
 0.94A 3sudB-5kp7A:
undetectable		 3sudB-5kp7A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kx6 GALACTOSIDE
2-ALPHA-L-FUCOSYLTRA
NSFERASE

(Arabidopsis
thaliana) 		PF03254
(XG_FTase) 		5 GLN A 448
TYR A 353
GLY A 421
ALA A 423
SER A 479
 None
 1.13A 3sudB-5kx6A:
undetectable		 3sudB-5kx6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb8 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 GLY A 166
ILE A 336
GLY A 342
ALA A 341
ALA A 401
 None
 1.02A 3sudB-5lb8A:
undetectable		 3sudB-5lb8A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldf GLUTAMINE SYNTHETASE

(Salmonella
enterica) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		6 ASP A 424
ILE A 343
GLY A 378
ALA A 377
ALA A 305
SER A 342
 None
 1.27A 3sudB-5ldfA:
undetectable		 3sudB-5ldfA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pyrobaculum
calidifontis) 		PF00490
(ALAD) 		5 TYR A 262
ILE A  28
GLY A 316
ALA A 315
ALA A 311
 None
 0.99A 3sudB-5lzlA:
undetectable		 3sudB-5lzlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2h I-ONUI_E-HTCRA

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		5 PHE A  18
ILE A 165
GLY A  17
ALA A  21
SER A 214
 None
None
None
CA  A 401 (-4.6A)
None
 1.13A 3sudB-5t2hA:
undetectable		 3sudB-5t2hA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2o I-ONUI_E-AG011377

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		5 PHE A  18
ILE A 165
GLY A  17
ALA A  21
SER A 214
 None
None
None
CA  A 401 (-4.8A)
None
 1.10A 3sudB-5t2oA:
undetectable		 3sudB-5t2oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8d I-ONUI_E-VHIVINT_V2

(synthetic
construct) 		PF00961
(LAGLIDADG_1) 		5 PHE A  18
ILE A 165
GLY A  17
ALA A  21
SER A 214
 None
None
None
CA  A 402 (-4.7A)
None
 1.05A 3sudB-5t8dA:
undetectable		 3sudB-5t8dA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t95 PREPHENATE
DEHYDROGENASE 1

(Glycine max) 		PF02153
(PDH) 		5 PHE A  23
GLY A 128
ASP A 222
GLY A  21
SER A  77
 None
TYR  A 302 ( 3.1A)
TYR  A 302 ( 2.9A)
None
NAP  A 301 (-3.5A)
 1.05A 3sudB-5t95A:
undetectable		 3sudB-5t95A:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00258
(Flavodoxin_1)
PF01392
(Fz)
PF01534
(Frizzled) 		5 GLY A 328
ILE A 389
GLY A 277
PHE A 526
SER A 387
 None
None
None
None
836  A1201 (-4.5A)
 1.00A 3sudB-5v57A:
undetectable		 3sudB-5v57A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 5 ILE A  72
GLY A 341
ALA A 246
PHE A 247
ALA A 230
 None
None
ACT  A 502 ( 3.9A)
None
None
 1.02A 3sudB-5vf5A:
undetectable		 3sudB-5vf5A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 8 GLN A  41
PHE A  43
TYR A  56
HIS A  57
ILE A 132
GLY A 137
PHE A 154
ALA A 156
 None
 0.72A 3sudB-5wdxA:
27.5		 3sudB-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 9 PHE A  43
TYR A  56
HIS A  57
GLY A  58
ASP A  81
ILE A 132
GLY A 137
PHE A 154
ALA A 156
 None
 0.50A 3sudB-5wdxA:
27.5		 3sudB-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 5 GLY A 341
ILE A 241
GLY A 355
ALA A 343
ALA A 375
 None
 0.92A 3sudB-5y31A:
undetectable		 3sudB-5y31A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 5 GLY A 341
ILE A 241
GLY A 356
ALA A 343
ALA A 375
 None
 1.10A 3sudB-5y31A:
undetectable		 3sudB-5y31A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 5 PHE A 155
GLY A 130
GLY A 154
ALA A 156
PHE A 170
 None
 0.94A 3sudB-5yp3A:
undetectable		 3sudB-5yp3A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dbr -

(-) 		no annotation 5 PHE B 206
GLY B 139
ILE B 234
GLY B 221
ALA B 209
 None
 0.91A 3sudB-6dbrB:
undetectable		 3sudB-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 GLN C 794
GLY C 751
ILE C 673
ALA C 713
ALA C 708
 None
 1.08A 3sudB-6en4C:
undetectable		 3sudB-6en4C:
16.23