SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUD_A_SUEA1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		4 PHE A 169
TYR A  25
ILE A 173
LEU A 145
 None
 1.48A 3sudA-1ciaA:
0.0		 3sudA-1ciaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		4 PHE P  99
TYR P 129
ILE P  51
LEU P  52
 None
 1.38A 3sudA-1jcmP:
undetectable		 3sudA-1jcmP:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksh ARF-LIKE PROTEIN 2

(Mus musculus) 		PF00025
(Arf) 		4 PHE A  50
TYR A  76
ILE A  88
LEU A  19
 None
 1.26A 3sudA-1kshA:
undetectable		 3sudA-1kshA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 PHE A 139
TYR A 152
ILE A 124
LEU A 109
 None
 1.15A 3sudA-1lf9A:
0.0		 3sudA-1lf9A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 PHE A 236
TYR A 277
ILE A 247
LEU A 244
 None
 1.46A 3sudA-1tvzA:
undetectable		 3sudA-1tvzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrj METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01035
(DNA_binding_1) 		4 PHE A  46
TYR A  41
ILE A 118
LEU A 115
 None
 1.43A 3sudA-1wrjA:
undetectable		 3sudA-1wrjA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		4 PHE A2418
TYR A2425
ILE A2405
LEU A2411
 None
 1.25A 3sudA-1xktA:
0.0		 3sudA-1xktA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 PHE A 207
TYR A 150
ILE A 283
LEU A 268
 None
 1.22A 3sudA-1z3zA:
0.0		 3sudA-1z3zA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A

(Homo sapiens) 		PF00025
(Arf) 		4 PHE A  36
TYR A 160
ILE A  72
LEU A  28
 None
 1.49A 3sudA-2h18A:
0.0		 3sudA-2h18A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqp POLYSIALIC ACID
CAPSULE BIOSYNTHESIS
PROTEIN SIAC

(Neisseria
meningitidis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 PHE A 237
TYR A  45
ILE A 232
LEU A 233
 None
 1.19A 3sudA-2wqpA:
undetectable		 3sudA-2wqpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOB

(Methylosinus
trichosporium) 		PF04744
(Monooxygenase_B) 		4 PHE A 406
TYR A  57
ILE A 374
LEU A 366
 None
 1.47A 3sudA-3chxA:
undetectable		 3sudA-3chxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 PHE A 256
TYR A  53
ILE A 262
LEU A 260
 None
 1.50A 3sudA-3cr8A:
undetectable		 3sudA-3cr8A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
agalactiae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 PHE A 230
TYR A 209
ILE A  16
LEU A  12
 GOL  A 265 (-3.7A)
None
None
None
 1.38A 3sudA-3eprA:
undetectable		 3sudA-3eprA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		4 PHE A 280
TYR A 271
ILE A 366
LEU A 363
 None
 1.39A 3sudA-3eu8A:
undetectable		 3sudA-3eu8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnt HAP PROTEIN

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 PHE A  31
TYR A 136
ILE A 213
LEU A 214
 None
 1.43A 3sudA-3fntA:
undetectable		 3sudA-3fntA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		4 PHE A  93
TYR A 240
ILE A 273
LEU A 271
 None
NA  A 437 ( 4.6A)
None
None
 1.39A 3sudA-3g0tA:
undetectable		 3sudA-3g0tA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A4109
TYR A4078
ILE A4136
LEU A4227
 None
 1.49A 3sudA-3g1nA:
undetectable		 3sudA-3g1nA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		4 PHE A  35
TYR A  24
ILE A  44
LEU A  43
 None
 1.28A 3sudA-3gveA:
undetectable		 3sudA-3gveA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 PHE A  28
TYR A  14
ILE A  87
LEU A  86
 None
 1.03A 3sudA-3hn2A:
undetectable		 3sudA-3hn2A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4n MONOTHIOL
GLUTAREDOXIN-6

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		4 PHE A 220
TYR A 150
ILE A 122
LEU A 125
 None
 1.17A 3sudA-3l4nA:
undetectable		 3sudA-3l4nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lre KINESIN-LIKE PROTEIN
KIF18A

(Homo sapiens) 		PF00225
(Kinesin) 		4 PHE A 232
TYR A 134
ILE A 327
LEU A 110
 None
 1.32A 3sudA-3lreA:
undetectable		 3sudA-3lreA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx9 PROTEIN SCV3V2(G19S)

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 PHE A  43
TYR A   5
ILE A 108
LEU A 104
 None
 1.46A 3sudA-3mx9A:
undetectable		 3sudA-3mx9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF00740
(Parvo_coat) 		4 PHE A 489
TYR A 502
ILE A 528
LEU A 523
 None
 0.99A 3sudA-3nttA:
undetectable		 3sudA-3nttA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 PHE A 828
TYR A 815
ILE A 786
LEU A 785
 None
 1.49A 3sudA-3opyA:
undetectable		 3sudA-3opyA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A  89
TYR A 257
ILE A  81
LEU A  84
 None
 1.27A 3sudA-3ozyA:
undetectable		 3sudA-3ozyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		4 PHE A  26
TYR A  75
ILE A  18
LEU A  21
 None
 1.01A 3sudA-3p5nA:
undetectable		 3sudA-3p5nA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnq PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIC COMPONENT

(Bacillus cereus) 		PF02378
(PTS_EIIC) 		4 PHE A 274
TYR A 391
ILE A  38
LEU A  36
 None
 1.46A 3sudA-3qnqA:
undetectable		 3sudA-3qnqA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A1349
TYR A1606
ILE A1298
LEU A1297
 BTI  A1901 (-4.6A)
None
None
None
 1.45A 3sudA-3va7A:
undetectable		 3sudA-3va7A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp2 EPITHELIAL ADHESIN 9

([Candida]
glabrata) 		PF10528
(GLEYA) 		4 PHE A 253
TYR A 227
ILE A 140
LEU A  63
 None
 1.43A 3sudA-4cp2A:
undetectable		 3sudA-4cp2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Yersinia pestis) 		PF00202
(Aminotran_3) 		4 PHE A 402
TYR A 392
ILE A  71
LEU A  64
 None
 1.41A 3sudA-4e77A:
undetectable		 3sudA-4e77A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 PHE A 114
TYR A  51
ILE A 198
LEU A 209
 None
 1.11A 3sudA-4gpgA:
11.4		 3sudA-4gpgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1a RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE I

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 PHE A 207
TYR A 200
ILE A 248
LEU A 249
 None
 1.34A 3sudA-4i1aA:
undetectable		 3sudA-4i1aA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j05 PHOSPHATE
TRANSPORTER

(Serendipita
indica) 		PF00083
(Sugar_tr) 		4 PHE A 485
TYR A 328
ILE A 394
LEU A 398
 None
PO4  A 600 (-4.5A)
None
None
 1.19A 3sudA-4j05A:
undetectable		 3sudA-4j05A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 PHE A 580
TYR A 476
ILE A 538
LEU A 537
 None
 1.04A 3sudA-4jzaA:
undetectable		 3sudA-4jzaA:
12.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 PHE A  43
TYR A  56
ILE A 132
LEU A 135
 2R8  A 301 (-4.6A)
None
2R8  A 301 (-4.3A)
2R8  A 301 (-4.4A)
 0.52A 3sudA-4nwkA:
34.8		 3sudA-4nwkA:
98.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 PHE A 383
TYR A 407
ILE A 462
LEU A 460
 HIS  A 502 (-4.6A)
None
None
None
 1.47A 3sudA-4oflA:
undetectable		 3sudA-4oflA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgw UNCHARACTERIZED
PROTEIN YETJ

(Bacillus
subtilis) 		PF01027
(Bax1-I) 		4 PHE A 108
TYR A 193
ILE A 162
LEU A 166
 None
 1.38A 3sudA-4pgwA:
undetectable		 3sudA-4pgwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt9 PUTATIVE
GLUCOAMYLASE

(Bacteroides
caccae) 		PF10091
(Glycoamylase) 		4 PHE A 290
TYR A 281
ILE A 376
LEU A 373
 ACT  A 501 ( 4.9A)
None
None
None
 1.37A 3sudA-4qt9A:
undetectable		 3sudA-4qt9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ued EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		4 PHE A 215
TYR A 145
ILE A 115
LEU A 114
 None
 1.32A 3sudA-4uedA:
0.7		 3sudA-4uedA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus) 		PF00423
(HN) 		4 PHE A 309
TYR A 247
ILE A 361
LEU A 312
 None
 1.46A 3sudA-4uf7A:
undetectable		 3sudA-4uf7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Cellvibrio sp.
BR) 		PF13738
(Pyr_redox_3) 		4 PHE A 101
TYR A  91
ILE A  19
LEU A  42
 None
 1.45A 3sudA-4usqA:
undetectable		 3sudA-4usqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		4 PHE A 401
TYR A 296
ILE A 357
LEU A 354
 TXE  A 501 ( 3.9A)
None
None
None
 1.49A 3sudA-5abmA:
undetectable		 3sudA-5abmA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN

(Coprinopsis
cinerea) 		PF03664
(Glyco_hydro_62) 		4 PHE A 168
TYR A 180
ILE A 350
LEU A 349
 None
 1.24A 3sudA-5b6tA:
undetectable		 3sudA-5b6tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 PHE A 658
TYR A 727
ILE A 653
LEU A 649
 None
 1.43A 3sudA-5dkxA:
undetectable		 3sudA-5dkxA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		4 PHE A 215
TYR A 145
ILE A 115
LEU A 114
 None
 1.25A 3sudA-5ei3A:
1.1		 3sudA-5ei3A:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 PHE A1043
TYR A1056
ILE A1132
LEU A1135
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-4.2A)
 0.37A 3sudA-5eqqA:
36.0		 3sudA-5eqqA:
94.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn7 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C

(Homo sapiens) 		PF12567
(CD45) 		4 PHE A  89
TYR A 156
ILE A 137
LEU A 106
 None
 1.46A 3sudA-5fn7A:
undetectable		 3sudA-5fn7A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 PHE A 551
TYR A 297
ILE A 624
LEU A 621
 None
 1.32A 3sudA-5gl7A:
undetectable		 3sudA-5gl7A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5b THYMIDYLATE KINASE

(Aquifex
aeolicus) 		no annotation 4 PHE B  91
TYR B  34
ILE B 172
LEU B 128
 None
 1.27A 3sudA-5h5bB:
undetectable		 3sudA-5h5bB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A1349
TYR A1606
ILE A1298
LEU A1297
 None
 1.44A 3sudA-5i8iA:
undetectable		 3sudA-5i8iA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3r MONOTHIOL
GLUTAREDOXIN-6

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		4 PHE A 220
TYR A 150
ILE A 122
LEU A 125
 None
 1.21A 3sudA-5j3rA:
undetectable		 3sudA-5j3rA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 PHE A1400
TYR A1330
ILE A1344
LEU A1343
 None
 1.40A 3sudA-5n2sA:
undetectable		 3sudA-5n2sA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL

(Homo sapiens) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 PHE d 228
TYR d 178
ILE d 276
LEU d 277
 None
 1.13A 3sudA-5oold:
undetectable		 3sudA-5oold:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tum TETRACYCLINE
DESTRUCTASE TET(56)

(Legionella
longbeachae) 		PF01494
(FAD_binding_3) 		4 PHE A  28
TYR A 323
ILE A  33
LEU A  32
 None
 1.19A 3sudA-5tumA:
undetectable		 3sudA-5tumA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 PHE A 208
TYR A 215
ILE A 353
LEU A 352
 None
 1.15A 3sudA-5u09A:
undetectable		 3sudA-5u09A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 4 PHE A  43
TYR A  56
ILE A 132
LEU A 135
 None
 0.60A 3sudA-5wdxA:
27.2		 3sudA-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		4 PHE A 400
TYR A 406
ILE A 391
LEU A 392
 None
 1.06A 3sudA-5xhqA:
undetectable		 3sudA-5xhqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 4 PHE A 319
TYR A 286
ILE A  87
LEU A  28
 None
 1.04A 3sudA-5xmdA:
undetectable		 3sudA-5xmdA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnw ADENYLATE CYCLASE
EXOY

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A  83
TYR A 132
ILE A  63
LEU A 215
 None
 1.45A 3sudA-5xnwA:
undetectable		 3sudA-5xnwA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		no annotation 4 PHE A 107
TYR A 230
ILE A  57
LEU A  84
 None
 1.27A 3sudA-5yt0A:
undetectable		 3sudA-5yt0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 4 PHE A 695
TYR A1089
ILE A 654
LEU A 650
 None
 1.34A 3sudA-6a91A:
undetectable		 3sudA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A  90
TYR A  26
ILE A  66
LEU A  77
 None
 1.50A 3sudA-6eojA:
undetectable		 3sudA-6eojA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 4 PHE A 286
TYR A 359
ILE A 261
LEU A 297
 None
 1.47A 3sudA-6fhwA:
undetectable		 3sudA-6fhwA:
19.39