SIMILAR PATTERNS OF AMINO ACIDS FOR 3SUD_A_SUEA1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 GLY A   7
GLY A  83
ALA A 230
ALA A 232
SER A 236
 None
 1.09A 3sudA-1c3lA:
undetectable		 3sudA-1c3lA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		5 GLN L 111
ASP L 490
PHE L 117
ALA L 121
ALA L 122
 None
 1.10A 3sudA-1cc1L:
undetectable		 3sudA-1cc1L:
17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		9 GLN A  41
HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.54A 3sudA-1cu1A:
34.6		 3sudA-1cu1A:
80.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e12 HALORHODOPSIN

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		5 GLY A 124
ALA A 127
PHE A 196
ALA A 184
SER A 177
 None
 1.05A 3sudA-1e12A:
undetectable		 3sudA-1e12A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.08A 3sudA-1efpA:
undetectable		 3sudA-1efpA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.04A 3sudA-1efvA:
undetectable		 3sudA-1efvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		5 GLY A 156
ALA A 160
PHE A 101
ALA A 469
SER A 462
 None
 1.08A 3sudA-1eyyA:
undetectable		 3sudA-1eyyA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 350
GLY A 161
ALA A 160
ALA A 156
ALA A 155
 None
 0.99A 3sudA-1gpeA:
undetectable		 3sudA-1gpeA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 GLY A 290
GLY A 463
ALA A 444
PHE A 443
ALA A 418
 None
 1.09A 3sudA-1gz4A:
undetectable		 3sudA-1gz4A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpg GLUTAMIC ACID
SPECIFIC PROTEASE

(Streptomyces
griseus) 		no annotation 5 HIS A  57
ASP A 102
GLY A 193
ALA A 226
SER A 225
 None
 0.95A 3sudA-1hpgA:
11.1		 3sudA-1hpgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		5 GLY D 167
ASP D 164
ARG D 502
GLY D 357
ALA D 359
 None
 1.08A 3sudA-1mhzD:
undetectable		 3sudA-1mhzD:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 GLN A  41
HIS A  57
GLY A  58
ASP A  81
ARG A 123
PHE A 154
ALA A 156
ALA A 157
 None
 0.78A 3sudA-1ns3A:
30.5		 3sudA-1ns3A:
77.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.55A 3sudA-1ns3A:
30.5		 3sudA-1ns3A:
77.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9h INVASIN

(Yersinia
enterocolitica) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  69
GLY A  97
ALA A  86
ALA A  88
ALA A 102
 None
 1.04A 3sudA-1p9hA:
undetectable		 3sudA-1p9hA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 GLN A 375
ALA A 141
PHE A 142
ALA A 162
ALA A 161
 None
 1.08A 3sudA-1pgjA:
undetectable		 3sudA-1pgjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		5 GLY A 581
GLY A 445
ALA A 559
ALA A 566
SER A 216
 None
NFS  A 639 (-3.6A)
None
None
None
 1.06A 3sudA-1su7A:
undetectable		 3sudA-1su7A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		5 GLY A  66
ASP A 117
GLY A  62
ALA A 109
ALA A 102
 None
 1.07A 3sudA-1sznA:
undetectable		 3sudA-1sznA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 GLY A  14
ARG A 103
GLY A 261
ALA A 276
ALA A 244
 None
 0.91A 3sudA-1x0lA:
undetectable		 3sudA-1x0lA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE

(Thermoplasma
acidophilum) 		PF00561
(Abhydrolase_1) 		5 HIS A 271
ASP A 244
GLY A  36
ALA A 105
SER A  47
 LEU  A 301 (-3.4A)
None
LEU  A 301 (-3.2A)
PHE  A 300 ( 3.0A)
None
 1.06A 3sudA-1xqwA:
undetectable		 3sudA-1xqwA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 GLY A 280
GLY A 450
ALA A 431
PHE A 430
ALA A 405
 None
 1.05A 3sudA-2aw5A:
undetectable		 3sudA-2aw5A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 296
ARG A 206
GLY A 182
ALA A 205
ALA A 210
 None
 1.07A 3sudA-2dphA:
undetectable		 3sudA-2dphA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE

(Thermus
thermophilus) 		PF00596
(Aldolase_II) 		5 GLY A  27
ARG A 144
GLY A 152
ALA A 155
ALA A 145
 None
 0.89A 3sudA-2fk5A:
undetectable		 3sudA-2fk5A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 GLY A  79
GLY A  43
ALA A  13
ALA A  15
ALA A  17
 None
 0.93A 3sudA-2i3aA:
undetectable		 3sudA-2i3aA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		5 GLY A 225
GLY A 267
PHE A 295
ALA A 273
ALA A 274
 PLP  A 400 (-3.5A)
None
None
None
None
 1.01A 3sudA-2isqA:
undetectable		 3sudA-2isqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuy GLYCOSYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00534
(Glycos_transf_1) 		6 GLN A 250
GLY A 186
GLY A 280
ALA A 247
ALA A 265
SER A 137
 None
 1.38A 3sudA-2iuyA:
undetectable		 3sudA-2iuyA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4r EXOPOLYPHOSPHATASE

(Aquifex
aeolicus) 		PF02541
(Ppx-GppA) 		5 HIS A 232
GLY A 233
GLY A 208
ALA A 126
ALA A 123
 None
 1.10A 3sudA-2j4rA:
undetectable		 3sudA-2j4rA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j92 PICORNAIN 3C

(Foot-and-mouth
disease virus) 		PF00548
(Peptidase_C3) 		5 HIS A  46
ASP A  84
GLY A 161
ALA A 163
ALA A 183
 None
 0.61A 3sudA-2j92A:
10.2		 3sudA-2j92A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4g HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF01872
(RibD_C) 		5 GLY A 229
GLY A  45
ALA A  47
ALA A  39
SER A 255
 None
None
EDO  A 280 ( 3.7A)
EDO  A 280 (-3.5A)
None
 1.10A 3sudA-2p4gA:
undetectable		 3sudA-2p4gA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 GLY A 387
ARG A 622
GLY A 368
ALA A 623
SER A 618
 None
 1.05A 3sudA-2pncA:
undetectable		 3sudA-2pncA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLN A 141
GLY A  10
ALA A 173
ALA A 168
SER A 105
 None
 1.09A 3sudA-2q27A:
undetectable		 3sudA-2q27A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 GLY G1653
GLY G1607
ALA G1655
ALA G1598
SER G1600
 None
 1.10A 3sudA-2uv8G:
undetectable		 3sudA-2uv8G:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyd HEMOPHORE HASA

(Serratia
marcescens) 		PF06438
(HasA) 		5 GLY X 101
GLY X  43
ALA X  56
PHE X  67
ALA X  69
 None
 1.10A 3sudA-2uydX:
undetectable		 3sudA-2uydX:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqh IMMUNOGLOBULIN-BINDI
NG PROTEIN EIBD

(Escherichia
coli) 		PF05658
(YadA_head) 		5 GLY A 173
GLY A 201
ALA A 190
ALA A 192
ALA A 206
 None
 0.98A 3sudA-2xqhA:
undetectable		 3sudA-2xqhA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		5 GLN A 215
ARG A 236
GLY A  14
ALA A  13
ALA A  36
 None
None
FAD  A 600 (-3.6A)
None
FAD  A 600 (-3.5A)
 1.06A 3sudA-2yg6A:
undetectable		 3sudA-2yg6A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwu DNA-3-METHYLADENINE
GLYCOSYLASE 2

(Escherichia
coli) 		PF00730
(HhH-GPD)
PF06029
(AlkA_N) 		5 ARG A  22
ALA A 136
ALA A 132
ALA A 131
SER A 127
 None
 1.04A 3sudA-3cwuA:
undetectable		 3sudA-3cwuA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF01063
(Aminotran_4) 		5 GLY A  79
ARG A 108
GLY A 270
ALA A 203
ALA A 202
 None
None
PLP  A 369 (-3.4A)
None
None
 1.08A 3sudA-3dtgA:
undetectable		 3sudA-3dtgA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A  90
ALA A  94
ALA A 182
ALA A 342
SER A 340
 None
 0.97A 3sudA-3e1hA:
undetectable		 3sudA-3e1hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A  90
ALA A  94
ALA A 182
ALA A 342
SER A 340
 None
 0.95A 3sudA-3euoA:
undetectable		 3sudA-3euoA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 GLN A 382
HIS A 226
ASP A 186
GLY A 384
ALA A 290
 None
 1.07A 3sudA-3gcwA:
undetectable		 3sudA-3gcwA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijf CYTIDINE DEAMINASE

(Mycobacterium
tuberculosis) 		PF00383
(dCMP_cyt_deam_1) 		5 GLY X  81
GLY X  19
ALA X  20
ALA X  57
ALA X  60
 None
 1.06A 3sudA-3ijfX:
undetectable		 3sudA-3ijfX:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		5 GLY A 248
GLY A 427
ALA A 406
ALA A 438
SER A 440
 None
None
None
SIN  A 504 (-3.8A)
SO4  A 503 ( 3.7A)
 1.08A 3sudA-3ju8A:
undetectable		 3sudA-3ju8A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv9 MALIC ENZYME

(Entamoeba
histolytica) 		PF00390
(malic)
PF03949
(Malic_M) 		5 GLY A 406
GLY A 205
ALA A 204
ALA A 199
SER A 230
 None
 1.09A 3sudA-3nv9A:
undetectable		 3sudA-3nv9A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens) 		PF01593
(Amino_oxidase) 		5 GLN A 217
ARG A 238
GLY A  16
ALA A  15
ALA A  38
 None
None
FDA  A 483 (-3.3A)
None
FDA  A 483 (-3.4A)
 1.05A 3sudA-3rhaA:
undetectable		 3sudA-3rhaA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 287
GLY A 288
ASP A 417
GLY A 302
ALA A 439
 FRU  A 902 (-4.0A)
None
None
FRU  A 902 ( 2.2A)
FRU  A 902 ( 3.7A)
 0.94A 3sudA-3s29A:
undetectable		 3sudA-3s29A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  22
GLY A  50
ALA A  39
ALA A  41
ALA A  55
 None
 0.98A 3sudA-3s6lA:
undetectable		 3sudA-3s6lA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  29
GLY A  57
ALA A  46
ALA A  48
ALA A  62
 None
CL  A 189 ( 4.0A)
None
None
None
 1.04A 3sudA-3s6lA:
undetectable		 3sudA-3s6lA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  64
GLY A  92
ALA A  81
ALA A  83
ALA A  97
 None
 0.88A 3sudA-3s6lA:
undetectable		 3sudA-3s6lA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  71
GLY A  99
ALA A  88
ALA A  90
ALA A 104
 None
IOD  A 179 ( 3.9A)
None
None
None
 0.98A 3sudA-3s6lA:
undetectable		 3sudA-3s6lA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 HIS A 127
ASP A 156
GLY A 261
ALA A 263
ALA A 296
 None
 0.98A 3sudA-3szeA:
8.5		 3sudA-3szeA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbh O-ACETYL SERINE
SULFHYDRYLASE

(Leishmania
donovani) 		PF00291
(PALP) 		5 ASP A 246
GLY A 193
ALA A 195
PHE A 181
ALA A 183
 None
 1.03A 3sudA-3tbhA:
undetectable		 3sudA-3tbhA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt6 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Bacillus
subtilis) 		PF00574
(CLP_protease) 		5 GLY A 106
ALA A 104
ALA A 100
ALA A  95
SER A  65
 None
 1.05A 3sudA-3tt6A:
undetectable		 3sudA-3tt6A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v76 FLAVOPROTEIN

(Sinorhizobium
meliloti) 		PF03486
(HI0933_like) 		6 GLY A  17
GLY A 367
ALA A 406
ALA A 408
ALA A  75
SER A  74
 None
FDA  A 547 (-3.5A)
FDA  A 547 ( 3.7A)
None
None
None
 1.43A 3sudA-3v76A:
undetectable		 3sudA-3v76A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Acinetobacter
baumannii) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 ASP A 162
ARG A 322
ALA A 321
ALA A 168
SER A 169
 None
 0.87A 3sudA-3zpcA:
undetectable		 3sudA-3zpcA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLY A 536
ARG A 437
GLY A 493
ALA A 416
ALA A 433
 None
A12  A1598 (-2.6A)
None
None
None
 1.09A 3sudA-3zu0A:
undetectable		 3sudA-3zu0A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da1 PROTEIN PHOSPHATASE
1K, MITOCHONDRIAL

(Homo sapiens) 		PF00481
(PP2C) 		5 GLY A 130
GLY A 265
ALA A 134
ALA A 190
SER A 205
 None
 0.94A 3sudA-4da1A:
undetectable		 3sudA-4da1A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dt5 ANTIFREEZE PROTEIN

(Rhagium
inquisitor) 		no annotation 5 GLY A  27
GLY A  69
ALA A  51
ALA A  53
ALA A  73
 None
 0.96A 3sudA-4dt5A:
undetectable		 3sudA-4dt5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri) 		no annotation 5 GLN A 250
GLY A 275
ARG A 358
GLY A 319
ALA A 312
 None
 1.03A 3sudA-4gjiA:
undetectable		 3sudA-4gjiA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		5 GLY A  18
GLY A 203
ALA A  37
ALA A  39
ALA A 211
 None
 1.02A 3sudA-4go4A:
undetectable		 3sudA-4go4A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 GLY A 192
ARG A 346
GLY A 275
ALA A 273
ALA A 301
 None
None
NDP  A 501 (-4.0A)
NDP  A 501 (-3.9A)
None
 1.10A 3sudA-4hxyA:
undetectable		 3sudA-4hxyA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kzp OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF00106
(adh_short) 		5 GLY A  98
ASP A 101
LYS A  73
ALA A  47
ALA A  43
 None
 0.96A 3sudA-4kzpA:
undetectable		 3sudA-4kzpA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 GLN A  41
HIS A  57
GLY A  58
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 2R8  A 301 ( 3.5A)
2R8  A 301 (-3.3A)
2R8  A 301 (-3.5A)
2R8  A 301 (-3.6A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
 0.20A 3sudA-4nwkA:
34.8		 3sudA-4nwkA:
98.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8o ALPHA-L-ARABINOFURAN
OSIDASE

(Streptomyces
thermoviolaceus) 		PF03664
(Glyco_hydro_62) 		5 GLY A 340
GLY A  74
ALA A  75
ALA A  77
ALA A 126
 None
 1.04A 3sudA-4o8oA:
undetectable		 3sudA-4o8oA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 GLN B 382
HIS B 226
ASP B 186
GLY B 384
ALA B 290
 None
 1.03A 3sudA-4ov6B:
undetectable		 3sudA-4ov6B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oyy CUTINASE

(Humicola
insolens) 		PF01083
(Cutinase) 		5 GLY A  27
GLY A 102
ALA A  25
ALA A 114
SER A 116
 None
 1.10A 3sudA-4oyyA:
undetectable		 3sudA-4oyyA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei) 		PF02608
(Bmp) 		5 GLY A 161
GLY A 211
ALA A 209
ALA A 233
ALA A 235
 None
None
None
None
BR  A 419 ( 4.5A)
 1.06A 3sudA-4p98A:
undetectable		 3sudA-4p98A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psd CARBOHYDRATE
ESTERASE FAMILY 5

(Trichoderma
reesei) 		PF01083
(Cutinase) 		5 GLY A  89
GLY A 161
ALA A  87
ALA A 173
SER A 175
 None
 0.90A 3sudA-4psdA:
undetectable		 3sudA-4psdA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psd CARBOHYDRATE
ESTERASE FAMILY 5

(Trichoderma
reesei) 		PF01083
(Cutinase) 		5 GLY A  89
GLY A 162
ALA A  87
ALA A 173
SER A 175
 None
 1.01A 3sudA-4psdA:
undetectable		 3sudA-4psdA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 GLY A 395
GLY A 426
ALA A 424
ALA A 420
ALA A 419
 None
 1.02A 3sudA-4qmeA:
undetectable		 3sudA-4qmeA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbn SUCROSE
SYNTHASE:GLYCOSYL
TRANSFERASES GROUP 1

(Nitrosomonas
europaea) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 HIS A 273
GLY A 274
ASP A 404
GLY A 288
ALA A 426
 None
 0.94A 3sudA-4rbnA:
undetectable		 3sudA-4rbnA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy9 PUTATIVE MCP-TYPE
SIGNAL TRANSDUCTION
PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		5 GLN A 232
GLY A 236
ALA A 315
ALA A 297
ALA A 298
 None
 0.94A 3sudA-4wy9A:
undetectable		 3sudA-4wy9A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus) 		PF05416
(Peptidase_C37) 		6 HIS A  30
ASP A  54
GLY A 137
ALA A 139
ALA A 159
ALA A 160
 None
 0.55A 3sudA-4x2xA:
10.6		 3sudA-4x2xA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		6 GLY A 408
ARG A 442
PHE A 412
ALA A 441
ALA A 444
SER A 448
 None
 1.36A 3sudA-4xeuA:
undetectable		 3sudA-4xeuA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynn PROTEASE DO

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A  81
ASP A 111
GLY A 188
ALA A 190
ALA A 207
 None
 0.27A 3sudA-4ynnA:
13.0		 3sudA-4ynnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzi SENSORY OPSIN
A,ARCHAEAL-TYPE
OPSIN 2

(Chlamydomonas
reinhardtii) 		PF01036
(Bac_rhodopsin) 		5 HIS A 288
GLY A 287
GLY A 272
PHE A 269
ALA A 206
 None
OLA  A 406 (-3.5A)
None
RET  A 401 ( 4.4A)
None
 1.07A 3sudA-4yziA:
undetectable		 3sudA-4yziA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 174
ALA A 176
ALA A 231
ALA A 188
SER A 136
 None
 1.08A 3sudA-4zo6A:
undetectable		 3sudA-4zo6A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abj VP2

(Enterovirus A) 		PF00073
(Rhv) 		5 ARG B 103
GLY B  93
ALA B  96
PHE B 245
ALA B 243
 None
 1.03A 3sudA-5abjB:
undetectable		 3sudA-5abjB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1h CYSTATHIONINE
BETA-SYNTHASE

(Lactobacillus
plantarum) 		PF00291
(PALP) 		5 ASP A 235
GLY A 183
ALA A 185
PHE A 171
ALA A 173
 None
 1.10A 3sudA-5b1hA:
undetectable		 3sudA-5b1hA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 HIS A 224
GLY A 223
ASP A 246
ALA A 243
ALA A 303
 None
 1.08A 3sudA-5cykA:
undetectable		 3sudA-5cykA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1

(Homo sapiens) 		PF02137
(A_deamin) 		5 GLY A 354
ARG A 348
GLY A 333
ALA A 347
SER A 344
 None
G  C   5 ( 3.2A)
None
None
None
 1.02A 3sudA-5ed1A:
undetectable		 3sudA-5ed1A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eny POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLN A 355
GLY A  12
GLY A   9
ALA A 101
PHE A 102
 None
 0.96A 3sudA-5enyA:
undetectable		 3sudA-5enyA:
13.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		11 GLN A1041
HIS A1057
GLY A1058
ASP A1081
ARG A1123
LYS A1136
GLY A1137
ALA A1139
PHE A1154
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.4A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.41A 3sudA-5eqqA:
36.0		 3sudA-5eqqA:
94.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewq AMIDASE

(Bacillus
anthracis) 		PF01425
(Amidase) 		5 GLY A 230
GLY A 245
ALA A 243
ALA A 290
ALA A 296
 None
 1.07A 3sudA-5ewqA:
undetectable		 3sudA-5ewqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A  39
GLY A 273
ALA A 753
ALA A 240
ALA A 237
 None
 0.90A 3sudA-5fjjA:
undetectable		 3sudA-5fjjA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 GLY B 160
ALA B 157
ALA B 149
ALA B 148
SER B 590
 None
 1.08A 3sudA-5fq6B:
undetectable		 3sudA-5fq6B:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 5 GLY A 143
ARG A 259
GLY A 186
ALA A 184
ALA A 204
 None
 0.88A 3sudA-5fzpA:
undetectable		 3sudA-5fzpA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hal UNCHARACTERIZED
PROTEIN

(Burkholderia
vietnamiensis) 		no annotation 5 GLY A  49
ALA A  70
ALA A  73
ALA A  93
SER A  94
 None
 0.94A 3sudA-5halA:
undetectable		 3sudA-5halA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm2 3C PROTEINASE

(Foot-and-mouth
disease virus) 		PF00548
(Peptidase_C3) 		5 HIS A  46
ASP A  84
GLY A 161
ALA A 163
ALA A 183
 None
 0.76A 3sudA-5hm2A:
9.8		 3sudA-5hm2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus) 		PF00291
(PALP) 		5 ASP A 249
GLY A 190
ALA A 192
PHE A 178
ALA A 180
 None
 0.93A 3sudA-5jjcA:
undetectable		 3sudA-5jjcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE

(Shewanella
oneidensis) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A   8
ALA A 246
ALA A 242
ALA A 241
SER A 237
 None
 1.10A 3sudA-5k8bA:
undetectable		 3sudA-5k8bA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Vibrio cholerae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 HIS A  48
ASP A  46
GLY A 250
PHE A 279
ALA A 247
 None
 1.05A 3sudA-5tr7A:
undetectable		 3sudA-5tr7A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01063
(Aminotran_4) 		5 GLY A  79
ARG A 108
GLY A 270
ALA A 203
ALA A 202
 7TS  A 400 (-3.1A)
None
7TS  A 400 (-3.4A)
None
None
 1.03A 3sudA-5u3fA:
undetectable		 3sudA-5u3fA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 GLN A 382
HIS A 226
ASP A 186
GLY A 384
ALA A 290
 None
 1.01A 3sudA-5vlhA:
undetectable		 3sudA-5vlhA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8p HOMOSERINE
O-ACETYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF00561
(Abhydrolase_1) 		5 GLY A 163
ARG A 238
GLY A 322
ALA A 184
ALA A 359
 None
 0.94A 3sudA-5w8pA:
undetectable		 3sudA-5w8pA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 6 GLN A  41
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.58A 3sudA-5wdxA:
27.2		 3sudA-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 8 HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.44A 3sudA-5wdxA:
27.2		 3sudA-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		5 ASP A 238
GLY A 184
ALA A 186
PHE A 172
ALA A 174
 None
 0.92A 3sudA-5xa2A:
undetectable		 3sudA-5xa2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw3 O-ACETYLSERINE LYASE

(Bacillus
anthracis) 		PF00291
(PALP) 		5 ASP A 237
GLY A 185
ALA A 187
PHE A 173
ALA A 175
 None
 1.05A 3sudA-5xw3A:
undetectable		 3sudA-5xw3A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bj9 ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 5 GLY A  11
GLY A  39
ALA A  13
ALA A 254
ALA A 253
 None
 0.89A 3sudA-6bj9A:
undetectable		 3sudA-6bj9A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 5 GLY A  11
ALA A 245
ALA A 241
ALA A 240
SER A 236
 None
 0.94A 3sudA-6blgA:
undetectable		 3sudA-6blgA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 5 GLY B 974
ASP B 759
ARG B1017
ALA B 266
ALA B 292
 None
 0.94A 3sudA-6btmB:
undetectable		 3sudA-6btmB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		4 PHE A 169
TYR A  25
ILE A 173
LEU A 145
 None
 1.48A 3sudA-1ciaA:
0.0		 3sudA-1ciaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		4 PHE P  99
TYR P 129
ILE P  51
LEU P  52
 None
 1.38A 3sudA-1jcmP:
undetectable		 3sudA-1jcmP:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksh ARF-LIKE PROTEIN 2

(Mus musculus) 		PF00025
(Arf) 		4 PHE A  50
TYR A  76
ILE A  88
LEU A  19
 None
 1.26A 3sudA-1kshA:
undetectable		 3sudA-1kshA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 PHE A 139
TYR A 152
ILE A 124
LEU A 109
 None
 1.15A 3sudA-1lf9A:
0.0		 3sudA-1lf9A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 PHE A 236
TYR A 277
ILE A 247
LEU A 244
 None
 1.46A 3sudA-1tvzA:
undetectable		 3sudA-1tvzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wrj METHYLATED-DNA--PROT
EIN-CYSTEINE
METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01035
(DNA_binding_1) 		4 PHE A  46
TYR A  41
ILE A 118
LEU A 115
 None
 1.43A 3sudA-1wrjA:
undetectable		 3sudA-1wrjA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkt FATTY ACID SYNTHASE

(Homo sapiens) 		PF00975
(Thioesterase) 		4 PHE A2418
TYR A2425
ILE A2405
LEU A2411
 None
 1.25A 3sudA-1xktA:
0.0		 3sudA-1xktA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 PHE A 207
TYR A 150
ILE A 283
LEU A 268
 None
 1.22A 3sudA-1z3zA:
0.0		 3sudA-1z3zA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A

(Homo sapiens) 		PF00025
(Arf) 		4 PHE A  36
TYR A 160
ILE A  72
LEU A  28
 None
 1.49A 3sudA-2h18A:
0.0		 3sudA-2h18A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqp POLYSIALIC ACID
CAPSULE BIOSYNTHESIS
PROTEIN SIAC

(Neisseria
meningitidis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 PHE A 237
TYR A  45
ILE A 232
LEU A 233
 None
 1.19A 3sudA-2wqpA:
undetectable		 3sudA-2wqpA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOB

(Methylosinus
trichosporium) 		PF04744
(Monooxygenase_B) 		4 PHE A 406
TYR A  57
ILE A 374
LEU A 366
 None
 1.47A 3sudA-3chxA:
undetectable		 3sudA-3chxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 PHE A 256
TYR A  53
ILE A 262
LEU A 260
 None
 1.50A 3sudA-3cr8A:
undetectable		 3sudA-3cr8A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epr HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
agalactiae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 PHE A 230
TYR A 209
ILE A  16
LEU A  12
 GOL  A 265 (-3.7A)
None
None
None
 1.38A 3sudA-3eprA:
undetectable		 3sudA-3eprA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eu8 PUTATIVE
GLUCOAMYLASE

(Bacteroides
fragilis) 		PF10091
(Glycoamylase)
PF11329
(DUF3131) 		4 PHE A 280
TYR A 271
ILE A 366
LEU A 363
 None
 1.39A 3sudA-3eu8A:
undetectable		 3sudA-3eu8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnt HAP PROTEIN

(Plasmodium
falciparum) 		PF00026
(Asp) 		4 PHE A  31
TYR A 136
ILE A 213
LEU A 214
 None
 1.43A 3sudA-3fntA:
undetectable		 3sudA-3fntA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		4 PHE A  93
TYR A 240
ILE A 273
LEU A 271
 None
NA  A 437 ( 4.6A)
None
None
 1.39A 3sudA-3g0tA:
undetectable		 3sudA-3g0tA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		4 PHE A4109
TYR A4078
ILE A4136
LEU A4227
 None
 1.49A 3sudA-3g1nA:
undetectable		 3sudA-3g1nA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		4 PHE A  35
TYR A  24
ILE A  44
LEU A  43
 None
 1.28A 3sudA-3gveA:
undetectable		 3sudA-3gveA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 PHE A  28
TYR A  14
ILE A  87
LEU A  86
 None
 1.03A 3sudA-3hn2A:
undetectable		 3sudA-3hn2A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4n MONOTHIOL
GLUTAREDOXIN-6

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		4 PHE A 220
TYR A 150
ILE A 122
LEU A 125
 None
 1.17A 3sudA-3l4nA:
undetectable		 3sudA-3l4nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lre KINESIN-LIKE PROTEIN
KIF18A

(Homo sapiens) 		PF00225
(Kinesin) 		4 PHE A 232
TYR A 134
ILE A 327
LEU A 110
 None
 1.32A 3sudA-3lreA:
undetectable		 3sudA-3lreA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mx9 PROTEIN SCV3V2(G19S)

(Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1) 		4 PHE A  43
TYR A   5
ILE A 108
LEU A 104
 None
 1.46A 3sudA-3mx9A:
undetectable		 3sudA-3mx9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntt CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
B) 		PF00740
(Parvo_coat) 		4 PHE A 489
TYR A 502
ILE A 528
LEU A 523
 None
 0.99A 3sudA-3nttA:
undetectable		 3sudA-3nttA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 PHE A 828
TYR A 815
ILE A 786
LEU A 785
 None
 1.49A 3sudA-3opyA:
undetectable		 3sudA-3opyA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PHE A  89
TYR A 257
ILE A  81
LEU A  84
 None
 1.27A 3sudA-3ozyA:
undetectable		 3sudA-3ozyA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		4 PHE A  26
TYR A  75
ILE A  18
LEU A  21
 None
 1.01A 3sudA-3p5nA:
undetectable		 3sudA-3p5nA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnq PTS SYSTEM,
CELLOBIOSE-SPECIFIC
IIC COMPONENT

(Bacillus cereus) 		PF02378
(PTS_EIIC) 		4 PHE A 274
TYR A 391
ILE A  38
LEU A  36
 None
 1.46A 3sudA-3qnqA:
undetectable		 3sudA-3qnqA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A1349
TYR A1606
ILE A1298
LEU A1297
 BTI  A1901 (-4.6A)
None
None
None
 1.45A 3sudA-3va7A:
undetectable		 3sudA-3va7A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp2 EPITHELIAL ADHESIN 9

([Candida]
glabrata) 		PF10528
(GLEYA) 		4 PHE A 253
TYR A 227
ILE A 140
LEU A  63
 None
 1.43A 3sudA-4cp2A:
undetectable		 3sudA-4cp2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Yersinia pestis) 		PF00202
(Aminotran_3) 		4 PHE A 402
TYR A 392
ILE A  71
LEU A  64
 None
 1.41A 3sudA-4e77A:
undetectable		 3sudA-4e77A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 PHE A 114
TYR A  51
ILE A 198
LEU A 209
 None
 1.11A 3sudA-4gpgA:
11.4		 3sudA-4gpgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1a RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE I

(Bacillus
subtilis) 		PF13424
(TPR_12) 		4 PHE A 207
TYR A 200
ILE A 248
LEU A 249
 None
 1.34A 3sudA-4i1aA:
undetectable		 3sudA-4i1aA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j05 PHOSPHATE
TRANSPORTER

(Serendipita
indica) 		PF00083
(Sugar_tr) 		4 PHE A 485
TYR A 328
ILE A 394
LEU A 398
 None
PO4  A 600 (-4.5A)
None
None
 1.19A 3sudA-4j05A:
undetectable		 3sudA-4j05A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jza UNCHARACTERIZED
PROTEIN

(Legionella
longbeachae) 		no annotation 4 PHE A 580
TYR A 476
ILE A 538
LEU A 537
 None
 1.04A 3sudA-4jzaA:
undetectable		 3sudA-4jzaA:
12.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 PHE A  43
TYR A  56
ILE A 132
LEU A 135
 2R8  A 301 (-4.6A)
None
2R8  A 301 (-4.3A)
2R8  A 301 (-4.4A)
 0.52A 3sudA-4nwkA:
34.8		 3sudA-4nwkA:
98.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 PHE A 383
TYR A 407
ILE A 462
LEU A 460
 HIS  A 502 (-4.6A)
None
None
None
 1.47A 3sudA-4oflA:
undetectable		 3sudA-4oflA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgw UNCHARACTERIZED
PROTEIN YETJ

(Bacillus
subtilis) 		PF01027
(Bax1-I) 		4 PHE A 108
TYR A 193
ILE A 162
LEU A 166
 None
 1.38A 3sudA-4pgwA:
undetectable		 3sudA-4pgwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qt9 PUTATIVE
GLUCOAMYLASE

(Bacteroides
caccae) 		PF10091
(Glycoamylase) 		4 PHE A 290
TYR A 281
ILE A 376
LEU A 373
 ACT  A 501 ( 4.9A)
None
None
None
 1.37A 3sudA-4qt9A:
undetectable		 3sudA-4qt9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ued EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		4 PHE A 215
TYR A 145
ILE A 115
LEU A 114
 None
 1.32A 3sudA-4uedA:
0.7		 3sudA-4uedA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus) 		PF00423
(HN) 		4 PHE A 309
TYR A 247
ILE A 361
LEU A 312
 None
 1.46A 3sudA-4uf7A:
undetectable		 3sudA-4uf7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usq PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Cellvibrio sp.
BR) 		PF13738
(Pyr_redox_3) 		4 PHE A 101
TYR A  91
ILE A  19
LEU A  42
 None
 1.45A 3sudA-4usqA:
undetectable		 3sudA-4usqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5abm RETINAL
DEHYDROGENASE 1

(Ovis aries) 		PF00171
(Aldedh) 		4 PHE A 401
TYR A 296
ILE A 357
LEU A 354
 TXE  A 501 ( 3.9A)
None
None
None
 1.49A 3sudA-5abmA:
undetectable		 3sudA-5abmA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN

(Coprinopsis
cinerea) 		PF03664
(Glyco_hydro_62) 		4 PHE A 168
TYR A 180
ILE A 350
LEU A 349
 None
 1.24A 3sudA-5b6tA:
undetectable		 3sudA-5b6tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 PHE A 658
TYR A 727
ILE A 653
LEU A 649
 None
 1.43A 3sudA-5dkxA:
undetectable		 3sudA-5dkxA:
12.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		4 PHE A 215
TYR A 145
ILE A 115
LEU A 114
 None
 1.25A 3sudA-5ei3A:
1.1		 3sudA-5ei3A:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		4 PHE A1043
TYR A1056
ILE A1132
LEU A1135
 5RS  A1203 (-4.3A)
SO4  A1201 ( 4.5A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-4.2A)
 0.37A 3sudA-5eqqA:
36.0		 3sudA-5eqqA:
94.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn7 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C

(Homo sapiens) 		PF12567
(CD45) 		4 PHE A  89
TYR A 156
ILE A 137
LEU A 106
 None
 1.46A 3sudA-5fn7A:
undetectable		 3sudA-5fn7A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 PHE A 551
TYR A 297
ILE A 624
LEU A 621
 None
 1.32A 3sudA-5gl7A:
undetectable		 3sudA-5gl7A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5b THYMIDYLATE KINASE

(Aquifex
aeolicus) 		no annotation 4 PHE B  91
TYR B  34
ILE B 172
LEU B 128
 None
 1.27A 3sudA-5h5bB:
undetectable		 3sudA-5h5bB:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A1349
TYR A1606
ILE A1298
LEU A1297
 None
 1.44A 3sudA-5i8iA:
undetectable		 3sudA-5i8iA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3r MONOTHIOL
GLUTAREDOXIN-6

(Saccharomyces
cerevisiae) 		PF00462
(Glutaredoxin) 		4 PHE A 220
TYR A 150
ILE A 122
LEU A 125
 None
 1.21A 3sudA-5j3rA:
undetectable		 3sudA-5j3rA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2s SOLUBLE CYTOCHROME
B562,ADENOSINE
RECEPTOR A1

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 PHE A1400
TYR A1330
ILE A1344
LEU A1343
 None
 1.40A 3sudA-5n2sA:
undetectable		 3sudA-5n2sA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL

(Homo sapiens) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 PHE d 228
TYR d 178
ILE d 276
LEU d 277
 None
 1.13A 3sudA-5oold:
undetectable		 3sudA-5oold:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tum TETRACYCLINE
DESTRUCTASE TET(56)

(Legionella
longbeachae) 		PF01494
(FAD_binding_3) 		4 PHE A  28
TYR A 323
ILE A  33
LEU A  32
 None
 1.19A 3sudA-5tumA:
undetectable		 3sudA-5tumA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 PHE A 208
TYR A 215
ILE A 353
LEU A 352
 None
 1.15A 3sudA-5u09A:
undetectable		 3sudA-5u09A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 4 PHE A  43
TYR A  56
ILE A 132
LEU A 135
 None
 0.60A 3sudA-5wdxA:
27.2		 3sudA-5wdxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli) 		PF00795
(CN_hydrolase) 		4 PHE A 400
TYR A 406
ILE A 391
LEU A 392
 None
 1.06A 3sudA-5xhqA:
undetectable		 3sudA-5xhqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 4 PHE A 319
TYR A 286
ILE A  87
LEU A  28
 None
 1.04A 3sudA-5xmdA:
undetectable		 3sudA-5xmdA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnw ADENYLATE CYCLASE
EXOY

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A  83
TYR A 132
ILE A  63
LEU A 215
 None
 1.45A 3sudA-5xnwA:
undetectable		 3sudA-5xnwA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		no annotation 4 PHE A 107
TYR A 230
ILE A  57
LEU A  84
 None
 1.27A 3sudA-5yt0A:
undetectable		 3sudA-5yt0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 4 PHE A 695
TYR A1089
ILE A 654
LEU A 650
 None
 1.34A 3sudA-6a91A:
undetectable		 3sudA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A  90
TYR A  26
ILE A  66
LEU A  77
 None
 1.50A 3sudA-6eojA:
undetectable		 3sudA-6eojA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 4 PHE A 286
TYR A 359
ILE A 261
LEU A 297
 None
 1.47A 3sudA-6fhwA:
undetectable		 3sudA-6fhwA:
19.39