SIMILAR PATTERNS OF AMINO ACIDS FOR 3SPK_B_TPVB100_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cj0 | PROTEIN (SERINEHYDROXYMETHYLTRANSFERASE) (Oryctolaguscuniculus) |
PF00464(SHMT) | 5 | ARG A 363LEU A 318ASN A 316VAL A 291GLY A 206 | None | 1.16A | 3spkA-1cj0A:undetectable | 3spkA-1cj0A:11.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cu1 | PROTEIN(PROTEASE/HELICASENS3) (Hepacivirus C) |
PF02907(Peptidase_S29)PF07652(Flavi_DEAD) | 5 | ARG A 464LEU A 365VAL A 389GLY A 404ILE A 403 | None | 1.22A | 3spkA-1cu1A:undetectable | 3spkA-1cu1A:9.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dbt | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Bacillussubtilis) |
PF00215(OMPdecase) | 5 | LEU A 122ALA A 89VAL A 144GLY A 158ILE A 117 | U5P A 250 (-4.2A)NoneNoneNoneNone | 1.21A | 3spkA-1dbtA:undetectable | 3spkA-1dbtA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ekq | HYDROXYETHYLTHIAZOLEKINASE (Bacillussubtilis) |
PF02110(HK) | 5 | LEU A 215ALA A 119VAL A 204GLY A 122ILE A 167 | None | 1.11A | 3spkA-1ekqA:undetectable | 3spkA-1ekqA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g3r | CELL DIVISIONINHIBITOR (Pyrococcusfuriosus) |
PF13614(AAA_31) | 5 | ALA A 130VAL A 8GLY A 134ILE A 4THR A 20 | None | 1.15A | 3spkA-1g3rA:undetectable | 3spkA-1g3rA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g60 | ADENINE-SPECIFICMETHYLTRANSFERASEMBOIIA (Moraxella bovis) |
PF01555(N6_N4_Mtase) | 5 | LEU A 215ALA A 230VAL A 28GLY A 224ILE A 7 | None | 1.33A | 3spkA-1g60A:undetectable | 3spkA-1g60A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h81 | POLYAMINE OXIDASE (Zea mays) |
PF01593(Amino_oxidase) | 5 | ALA A 451VAL A 7GLY A 16ILE A 17THR A 29 | None | 1.35A | 3spkA-1h81A:undetectable | 3spkA-1h81A:11.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ALA A 28VAL A 32GLY A 49ILE A 50 | A79 A 800 (-3.4A)A79 A 800 ( 3.8A)A79 A 800 (-3.1A)A79 A 800 ( 4.4A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A) | 0.74A | 3spkA-1hvcA:13.2 | 3spkA-1hvcA:42.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ALA A 28VAL A 32GLY A 49ILE A 50 | A79 A 800 (-3.6A)A79 A 800 ( 4.0A)A79 A 800 (-3.2A)A79 A 800 ( 4.3A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A) | 0.74A | 3spkA-1hvcA:13.2 | 3spkA-1hvcA:42.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | LEU A 23ALA A 28VAL A 32GLY A 49PRO A 81 | A79 A 800 ( 4.0A)A79 A 800 (-3.2A)A79 A 800 ( 4.3A)A79 A 800 (-3.4A)A79 A 800 ( 3.4A) | 0.71A | 3spkA-1hvcA:13.2 | 3spkA-1hvcA:42.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ion | PROBABLE CELLDIVISION INHIBITORMIND (Pyrococcushorikoshii) |
PF13614(AAA_31) | 5 | ALA A 130VAL A 8GLY A 134ILE A 4THR A 20 | None | 1.19A | 3spkA-1ionA:undetectable | 3spkA-1ionA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jya | YOPE REGULATOR (Yersiniapseudotuberculosis) |
PF05932(CesT) | 5 | LEU A 74ASN A 91VAL A 111ILE A 38THR A 105 | None | 1.19A | 3spkA-1jyaA:undetectable | 3spkA-1jyaA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o5w | AMINE OXIDASE[FLAVIN-CONTAINING]A (Rattusnorvegicus) |
PF01593(Amino_oxidase) | 5 | LEU A 233ALA A 29VAL A 238GLY A 22ILE A 23 | NoneNoneNoneFAD A 652 (-3.4A)FAD A 652 (-4.8A) | 0.83A | 3spkA-1o5wA:undetectable | 3spkA-1o5wA:12.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ARG A 8LEU A 23ALA A 28GLY A 49ILE A 50 | None | 0.73A | 3spkA-1sivA:18.8 | 3spkA-1sivA:47.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ARG A 8LEU A 23ALA A 28GLY A 49PRO A 81 | None | 0.96A | 3spkA-1sivA:18.8 | 3spkA-1sivA:47.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sxj | ACTIVATOR 1 37 KDASUBUNITACTIVATOR 1 95 KDASUBUNIT (Saccharomycescerevisiae) |
PF00004(AAA)PF08519(RFC1)PF08542(Rep_fac_C) | 5 | ARG B 285LEU B 286ALA A 653GLY A 561ILE A 563 | None | 1.32A | 3spkA-1sxjB:undetectable | 3spkA-1sxjB:16.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to3 | PUTATIVE ALDOLASEYIHT (Salmonellaenterica) |
PF01791(DeoC) | 5 | ALA A 189VAL A 142GLY A 185ILE A 218PRO A 160 | None | 0.91A | 3spkA-1to3A:undetectable | 3spkA-1to3A:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ufo | HYPOTHETICAL PROTEINTT1662 (Thermusthermophilus) |
no annotation | 5 | ARG A 18LEU A 41ALA A 110GLY A 227PRO A 45 | None | 1.15A | 3spkA-1ufoA:undetectable | 3spkA-1ufoA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v87 | DELTEX PROTEIN 2 (Mus musculus) |
PF00097(zf-C3HC4) | 5 | LEU A 70VAL A 12GLY A 93ILE A 91THR A 17 | None | 1.25A | 3spkA-1v87A:undetectable | 3spkA-1v87A:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y9u | PUTATIVE IRONBINDING PROTEIN (Bordetellapertussis) |
PF13343(SBP_bac_6) | 5 | ARG A 121GLY A 194ILE A 193PRO A 225THR A 226 | None | 1.34A | 3spkA-1y9uA:undetectable | 3spkA-1y9uA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yxo | 4-HYDROXYTHREONINE-4-PHOSPHATEDEHYDROGENASE 1 (Pseudomonasaeruginosa) |
PF04166(PdxA) | 5 | VAL A1096GLY A1014ILE A1015PRO A1009THR A1008 | None | 1.27A | 3spkA-1yxoA:undetectable | 3spkA-1yxoA:16.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dkj | SERINEHYDROXYMETHYLTRANSFERASE (Thermusthermophilus) |
PF00464(SHMT) | 5 | ARG A 358LEU A 313ASN A 311VAL A 286GLY A 203 | SO4 A2520 (-2.9A)NoneNoneNoneNone | 1.24A | 3spkA-2dkjA:undetectable | 3spkA-2dkjA:12.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 5 | ARG A 8LEU A 23ALA A 28VAL A 32GLY A 55 | LP1 A 201 (-3.5A)NoneLP1 A 201 (-3.5A)NoneLP1 A 201 (-3.4A) | 0.64A | 3spkA-2fmbA:15.0 | 3spkA-2fmbA:31.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 5 | LEU A 23ALA A 28VAL A 32GLY A 55PRO A 86 | NoneLP1 A 201 (-3.5A)NoneLP1 A 201 (-3.4A)LP1 A 201 (-3.9A) | 0.70A | 3spkA-2fmbA:15.0 | 3spkA-2fmbA:31.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gh9 | MALTOSE/MALTODEXTRIN-BINDING PROTEIN (Thermusthermophilus) |
PF13416(SBP_bac_8) | 5 | ARG A 305ASN A 300VAL A 313GLY A 324ILE A 249 | MLR A2913 (-3.0A)NoneNoneNoneNone | 1.30A | 3spkA-2gh9A:undetectable | 3spkA-2gh9A:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h92 | CYTIDYLATE KINASE (Staphylococcusaureus) |
PF02224(Cytidylate_kin) | 5 | LEU A 8ALA A 24VAL A 32GLY A 120ILE A 4 | None | 1.21A | 3spkA-2h92A:undetectable | 3spkA-2h92A:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iai | PUTATIVETRANSCRIPTIONALREGULATOR SCO3833 (Streptomycescoelicolor) |
PF00440(TetR_N) | 5 | ARG A 59LEU A 15VAL A 21GLY A 40ILE A 41 | None | 1.35A | 3spkA-2iaiA:undetectable | 3spkA-2iaiA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nzj | GTP-BINDING PROTEINREM 1 (Homo sapiens) |
PF00071(Ras) | 5 | LEU A 228VAL A 232GLY A 194ILE A 163THR A 227 | NoneNoneNoneNoneGDP A1001 (-3.3A) | 1.31A | 3spkA-2nzjA:undetectable | 3spkA-2nzjA:23.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ALA A 28GLY A 49ILE A 50PRO A 81 | AB1 A 501 ( 4.7A)NoneAB1 A 501 (-3.5A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A) | 0.82A | 3spkA-2rkfA:20.6 | 3spkA-2rkfA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vmx | SERINEHYDROXYMETHYLTRANSFERASE (Geobacillusstearothermophilus) |
PF00464(SHMT) | 5 | ARG A 357LEU A 312ASN A 310VAL A 285GLY A 203 | ALO A 502 (-3.0A)NoneNoneNoneNone | 1.23A | 3spkA-2vmxA:undetectable | 3spkA-2vmxA:15.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3c | GENERAL VESICULARTRANSPORT FACTORP115 (Homo sapiens) |
PF04869(Uso1_p115_head) | 5 | LEU A 386ALA A 440VAL A 373GLY A 422ILE A 403 | None | 1.22A | 3spkA-2w3cA:undetectable | 3spkA-2w3cA:10.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x98 | ALKALINE PHOSPHATASE (Halobacteriumsalinarum) |
PF00245(Alk_phosphatase) | 5 | ALA A 52GLY A 161ILE A 163PRO A 173THR A 172 | NoneNoneNoneNone MG A1477 (-3.1A) | 1.21A | 3spkA-2x98A:undetectable | 3spkA-2x98A:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z5x | AMINE OXIDASE[FLAVIN-CONTAINING]A (Homo sapiens) |
PF01593(Amino_oxidase) | 5 | LEU A 233ALA A 29VAL A 238GLY A 22ILE A 23 | NoneNoneNoneFAD A 600 (-3.2A)FAD A 600 (-4.9A) | 0.77A | 3spkA-2z5xA:undetectable | 3spkA-2z5xA:12.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aj6 | MAIN HEMAGGLUTININCOMPONENT (Clostridiumbotulinum) |
no annotation | 5 | LEU A 158ASN A 278VAL A 268ILE A 244THR A 156 | None | 1.26A | 3spkA-3aj6A:undetectable | 3spkA-3aj6A:14.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayr | ENDOGLUCANASE (Piromycesrhizinflatus) |
PF00150(Cellulase) | 5 | LEU A 107GLY A 277ILE A 309PRO A 68THR A 69 | None | 1.26A | 3spkA-3ayrA:undetectable | 3spkA-3ayrA:13.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7f | GLYCOSYL HYDROLASE,BNR REPEAT (Cupriaviduspinatubonensis) |
no annotation | 5 | ARG A 84ALA A 73VAL A 116GLY A 79PRO A 98 | None | 1.34A | 3spkA-3b7fA:undetectable | 3spkA-3b7fA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3edy | TRIPEPTIDYL-PEPTIDASE 1 (Homo sapiens) |
PF09286(Pro-kuma_activ) | 5 | ARG A 208VAL A 388GLY A 483PRO A 551THR A 550 | NAG A 564 (-3.8A)NoneNoneNoneNone | 1.22A | 3spkA-3edyA:undetectable | 3spkA-3edyA:10.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewm | UNCHARACTERIZEDSUGAR KINASE PH1459 (Pyrococcushorikoshii) |
PF00294(PfkB) | 5 | ALA A 108VAL A 80GLY A 8ILE A 134THR A 113 | None | 1.34A | 3spkA-3ewmA:undetectable | 3spkA-3ewmA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fbq | CONSERVED DOMAINPROTEIN (Bacillusanthracis) |
PF13786(DUF4179) | 5 | LEU A 31ASN A 32GLY A 7ILE A 9THR A 29 | None | 1.23A | 3spkA-3fbqA:undetectable | 3spkA-3fbqA:14.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gjb | CYTC3 (Streptomycessp.) |
PF05721(PhyH) | 5 | LEU A 283ALA A 288ILE A 132PRO A 269THR A 271 | None | 1.19A | 3spkA-3gjbA:undetectable | 3spkA-3gjbA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gq2 | GENERAL VESICULARTRANSPORT FACTORP115 (Bos taurus) |
PF04869(Uso1_p115_head) | 5 | LEU A 386ALA A 440VAL A 373GLY A 422ILE A 403 | None | 1.19A | 3spkA-3gq2A:undetectable | 3spkA-3gq2A:10.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb4 | VP0VP1VP3 (Parechovirus B) |
PF00073(Rhv)no annotation | 5 | ASN B 183ALA B 185GLY C 173ILE C 172THR A 49 | None | 1.21A | 3spkA-3jb4B:undetectable | 3spkA-3jb4B:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9d | ALDEHYDEDEHYDROGENASE (Listeriamonocytogenes) |
PF00171(Aldedh) | 5 | LEU A 414ASN A 433ALA A 417ILE A 250THR A 412 | None | 1.13A | 3spkA-3k9dA:undetectable | 3spkA-3k9dA:12.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lme | POSSIBLE TRANSLATIONINITIATION INHIBITOR (Rhodopseudomonaspalustris) |
PF01042(Ribonuc_L-PSP) | 5 | ALA A 91GLY A 48ILE A 31PRO A 41THR A 40 | None | 0.91A | 3spkA-3lmeA:undetectable | 3spkA-3lmeA:20.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ALA A 28VAL A 32GLY A 49ILE A 50PRO A 81 | None | 0.78A | 3spkA-3mwsA:19.7 | 3spkA-3mwsA:71.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0l | SERINEHYDROXYMETHYLTRANSFERASE (Campylobacterjejuni) |
PF00464(SHMT) | 5 | ARG A 356LEU A 311ASN A 309VAL A 284GLY A 201 | SO4 A 417 (-2.7A)NoneNoneNoneNone | 1.20A | 3spkA-3n0lA:undetectable | 3spkA-3n0lA:13.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r1j | ALPHA-KETOGLUTARATE-DEPENDENT TAURINEDIOXYGENASE (Mycobacteriumavium) |
PF02668(TauD) | 5 | LEU A 40ALA A 111GLY A 273PRO A 192THR A 194 | NoneEDO A 298 ( 3.9A)NoneNoneNone | 1.30A | 3spkA-3r1jA:undetectable | 3spkA-3r1jA:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sf6 | GLUTARYL-COADEHYDROGENASE (Mycolicibacteriumsmegmatis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | ARG A 34LEU A 92ALA A 314GLY A 308ILE A 20 | EDO A 413 (-4.0A)EDO A 413 ( 4.6A)NoneNoneNone | 1.34A | 3spkA-3sf6A:undetectable | 3spkA-3sf6A:14.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8LEU A 23GLY A 49ILE A 50PRO A 81 | SO4 A 101 (-3.8A)SO4 A 101 (-4.2A)017 A 201 (-4.0A)017 A 201 (-3.3A)None | 0.80A | 3spkA-3t3cA:18.9 | 3spkA-3t3cA:74.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ALA A 28VAL A 32GLY A 49ILE A 50PRO A 81 | SO4 A 101 (-4.2A)017 A 201 (-3.5A)None017 A 201 (-4.0A)017 A 201 (-3.3A)None | 0.38A | 3spkA-3t3cA:18.9 | 3spkA-3t3cA:74.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8l | ADENINE DEAMINASE 2 (Agrobacteriumfabrum) |
PF01979(Amidohydro_1)PF13382(Adenine_deam_C) | 5 | LEU A 302ALA A 327VAL A 118ILE A 257THR A 288 | None | 1.11A | 3spkA-3t8lA:undetectable | 3spkA-3t8lA:9.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ALA A 28GLY A 49ILE A 50PRO A 81 | 017 A 201 ( 4.8A)None017 A 201 (-3.4A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A) | 0.66A | 3spkA-3ttpA:20.0 | 3spkA-3ttpA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4g | NAMN:DMBPHOSPHORIBOSYLTRANSFERASE (Pyrococcushorikoshii) |
no annotation | 5 | ALA A 41VAL A 301ILE A 35PRO A 143THR A 142 | NoneNoneNoneSO4 A 336 (-4.4A)None | 0.93A | 3spkA-3u4gA:undetectable | 3spkA-3u4gA:19.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ALA A 28GLY A 49ILE A 50PRO A 81 | NoneNone017 A 201 (-3.4A)017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.56A | 3spkA-3u7sA:19.9 | 3spkA-3u7sA:80.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3up8 | PUTATIVE2,5-DIKETO-D-GLUCONIC ACID REDUCTASE B (Sinorhizobiummeliloti) |
PF00248(Aldo_ket_red) | 5 | LEU A 94ALA A 56GLY A 61ILE A 62THR A 96 | None | 1.32A | 3spkA-3up8A:undetectable | 3spkA-3up8A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wrc | GALLATE DIOXYGENASE (Sphingomonaspaucimobilis) |
PF02900(LigB)PF07746(LigA) | 5 | ARG A 143ALA A 185GLY A 6ILE A 4PRO A 49 | None | 1.32A | 3spkA-3wrcA:undetectable | 3spkA-3wrcA:13.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wy2 | ALPHA-GLUCOSIDASE (Halomonas sp.H11) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 5 | ARG A 456LEU A 453ASN A 46VAL A 42GLY A 94 | None | 1.34A | 3spkA-3wy2A:undetectable | 3spkA-3wy2A:10.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x29 | CLAUDIN-19 (Mus musculus) |
PF00822(PMP22_Claudin) | 5 | LEU A 50ALA A 164VAL A 137GLY A 20ILE A 22 | None | 1.22A | 3spkA-3x29A:undetectable | 3spkA-3x29A:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyx | AMINE OXIDASE[FLAVIN-CONTAINING]B (Homo sapiens) |
PF01593(Amino_oxidase) | 5 | LEU A 224ALA A 20VAL A 229GLY A 13ILE A 14 | NoneNoneNoneFAD A 600 (-3.4A)FAD A 600 (-4.8A) | 0.80A | 3spkA-3zyxA:undetectable | 3spkA-3zyxA:11.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4awd | BETA-PORPHYRANASE (Bacteroidesplebeius) |
no annotation | 5 | LEU A 116ASN A 97GLY A 181ILE A 182THR A 285 | None | 1.33A | 3spkA-4awdA:undetectable | 3spkA-4awdA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1l | 2-DEHYDRO-3-DEOXYPHOSPHOHEPTONATEALDOLASE (Pyrococcusfuriosus) |
PF00793(DAHP_synth_1) | 5 | ARG A 206LEU A 243ALA A 28VAL A 42GLY A 56 | None | 1.33A | 3spkA-4c1lA:undetectable | 3spkA-4c1lA:15.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvy | DIOXYGENASERV3406/MT3514 (Mycobacteriumtuberculosis) |
PF02668(TauD) | 5 | LEU A 39ALA A 109GLY A 271PRO A 190THR A 192 | None | 1.26A | 3spkA-4cvyA:undetectable | 3spkA-4cvyA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gp1 | POLYPRENYLSYNTHETASE (Pyrobaculumcalidifontis) |
PF00348(polyprenyl_synt) | 5 | ARG A 47LEU A 21ALA A 119GLY A 113ILE A 83 | None | 1.34A | 3spkA-4gp1A:undetectable | 3spkA-4gp1A:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hnn | DIHYDRODIPICOLINATESYNTHASE (Vitis vinifera) |
PF00701(DHDPS) | 5 | LEU A 266ASN A 262VAL A 254GLY A 205ILE A 223 | NoneNoneNoneKPI A 184 ( 4.3A)KPI A 184 ( 3.5A) | 1.23A | 3spkA-4hnnA:undetectable | 3spkA-4hnnA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4idm | DELTA-1-PYRROLINE-5-CARBOXYLATEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00171(Aldedh) | 5 | ALA A 84VAL A 248ILE A 238PRO A 213THR A 242 | None | 1.11A | 3spkA-4idmA:undetectable | 3spkA-4idmA:11.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ivn | TRANSCRIPTIONALREGULATOR (Vibriovulnificus) |
PF01380(SIS)PF01418(HTH_6) | 5 | ALA A 180GLY A 131ILE A 130PRO A 203THR A 220 | None | 1.29A | 3spkA-4ivnA:undetectable | 3spkA-4ivnA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j5i | ALPHA-KETOGLUTARATE-DEPENDENT TAURINEDIOXYGENASE (Mycolicibacteriumsmegmatis) |
PF02668(TauD) | 5 | LEU A 39ALA A 107GLY A 268PRO A 187THR A 189 | None | 1.31A | 3spkA-4j5iA:undetectable | 3spkA-4j5iA:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jq0 | FIBROBLAST GROWTHFACTOR 12SODIUM CHANNELPROTEIN TYPE 5SUBUNIT ALPHA (Homo sapiens) |
PF00167(FGF)PF16905(GPHH) | 5 | LEU A 51VAL A 148GLY D1845PRO A 145THR A 18 | None | 1.13A | 3spkA-4jq0A:undetectable | 3spkA-4jq0A:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ko2 | PERIPLASMIC [NIFESE]HYDROGENASE SMALLSUBUNIT (Desulfomicrobiumbaculatum) |
PF01058(Oxidored_q6)PF14720(NiFe_hyd_SSU_C) | 5 | LEU S 175ALA S 119VAL S 182GLY S 70PRO S 9 | None | 1.29A | 3spkA-4ko2S:undetectable | 3spkA-4ko2S:18.25 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ALA A 28VAL A 32GLY A 49ILE A 50THR A 82 | RIT A 500 (-3.2A)NoneRIT A 500 (-3.6A)NoneRIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.5A) | 0.79A | 3spkA-4njvA:20.0 | 3spkA-4njvA:87.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ALA A 28VAL A 32GLY A 49PRO A 81THR A 82 | NoneRIT A 500 (-3.6A)NoneRIT A 500 (-3.4A)RIT A 500 (-3.9A)RIT A 500 (-3.5A) | 0.92A | 3spkA-4njvA:20.0 | 3spkA-4njvA:87.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ofs | PROBABLE LIPOAMIDEACYLTRANSFERASE (Thermoplasmaacidophilum) |
PF00198(2-oxoacid_dh) | 5 | ALA A 114VAL A 67GLY A 61ILE A 126THR A 149 | None | 0.99A | 3spkA-4ofsA:undetectable | 3spkA-4ofsA:17.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q5t | LIPOPROTEIN (Streptococcusmutans) |
PF03180(Lipoprotein_9) | 5 | LEU A 197ALA A 140GLY A 137ILE A 133THR A 120 | None | 1.22A | 3spkA-4q5tA:undetectable | 3spkA-4q5tA:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y2w | ALANINE RACEMASE 1 (Caldanaerobactersubterraneus) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | ARG A 23ALA A 37VAL A 51ILE A 228THR A 19 | None | 1.29A | 3spkA-4y2wA:undetectable | 3spkA-4y2wA:14.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | ARG A 10LEU A 30ALA A 35VAL A 39GLY A 58 | NoneNone4B1 A 201 (-3.6A)None4B1 A 201 (-3.4A) | 0.80A | 3spkA-4ydfA:12.4 | 3spkA-4ydfA:31.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z5p | CYTOCHROME P450HYDROXYLASE (Streptomycesatroolivaceus) |
PF00067(p450) | 5 | ARG A 263LEU A 259ALA A 251GLY A 246ILE A 136 | None | 1.18A | 3spkA-4z5pA:undetectable | 3spkA-4z5pA:12.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a3f | DYNAMIN 3 (Homo sapiens) |
PF00169(PH)PF00350(Dynamin_N)PF01031(Dynamin_M)PF02212(GED) | 5 | VAL A 124GLY A 53ILE A 248PRO A 127THR A 75 | None | 1.35A | 3spkA-5a3fA:undetectable | 3spkA-5a3fA:9.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bwi | GLYCOSIDE HYDROLASEFAMILY 79 (Burkholderiapseudomallei) |
PF12891(Glyco_hydro_44) | 5 | ARG A 95ALA A 128GLY A 110ILE A 66THR A 89 | None | 1.34A | 3spkA-5bwiA:undetectable | 3spkA-5bwiA:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cmc | ML032222A IGLUR (Mnemiopsisleidyi) |
PF10613(Lig_chan-Glu_bd) | 5 | ASN A 31VAL A 42GLY A 13ILE A 56THR A 52 | None | 1.16A | 3spkA-5cmcA:undetectable | 3spkA-5cmcA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5evy | SALICYLATEHYDROXYLASE (Pseudomonasputida) |
PF01494(FAD_binding_3) | 5 | LEU X 212VAL X 230GLY X 191ILE X 285THR X 195 | None | 1.14A | 3spkA-5evyX:undetectable | 3spkA-5evyX:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gjj | HEAT SHOCK 70 KDAPROTEIN 1A (Homo sapiens) |
PF00012(HSP70) | 5 | LEU A 19ALA A 106VAL A 54ILE A 43THR A 21 | None | 1.13A | 3spkA-5gjjA:undetectable | 3spkA-5gjjA:14.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ho9 | EXTRACELLULARARABINANASE (Geobacillusstearothermophilus) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 5 | LEU A 208ASN A 204GLY A 162ILE A 161PRO A 272 | None | 1.15A | 3spkA-5ho9A:undetectable | 3spkA-5ho9A:10.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hp6 | EXTRACELLULARARABINANASE (Geobacillusstearothermophilus) |
PF04616(Glyco_hydro_43)PF13385(Laminin_G_3)PF16369(GH43_C) | 5 | LEU A 208ASN A 204GLY A 162ILE A 161PRO A 272 | None | 1.10A | 3spkA-5hp6A:undetectable | 3spkA-5hp6A:9.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i01 | PHOSPHOHEPTOSEISOMERASE (Neisseriagonorrhoeae) |
PF13580(SIS_2) | 5 | LEU A 26VAL A 162GLY A 118ILE A 119THR A 30 | None | 1.19A | 3spkA-5i01A:undetectable | 3spkA-5i01A:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kyv | LUCIFERIN4-MONOOXYGENASE (Photinuspyralis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ALA A 296GLY A 324ILE A 336PRO A 289THR A 290 | None | 1.22A | 3spkA-5kyvA:undetectable | 3spkA-5kyvA:11.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nv3 | RIBULOSEBISPHOSPHATECARBOXYLASE LARGECHAIN (Rhodobactersphaeroides) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | ARG A 163VAL A 375ILE A 281PRO A 154THR A 155 | None | 1.07A | 3spkA-5nv3A:undetectable | 3spkA-5nv3A:12.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ALA A 28VAL A 32GLY A 49ILE A 50 | None | 0.58A | 3spkA-5t2zA:21.3 | 3spkA-5t2zA:84.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | LEU A 23ALA A 28VAL A 32GLY A 49ILE A 50PRO A 81 | None | 0.64A | 3spkA-5t2zA:21.3 | 3spkA-5t2zA:84.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uhu | MYCINAMICIN IVHYDROXYLASE/EPOXIDASE (Micromonosporagriseorubida) |
PF00067(p450) | 5 | LEU A 45ALA A 285VAL A 52GLY A 338THR A 47 | NoneHEM A 401 (-3.6A)NoneNoneNone | 1.16A | 3spkA-5uhuA:undetectable | 3spkA-5uhuA:12.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uoh | CARBOXYLESTERASE A (Mycobacteriumtuberculosis) |
PF00561(Abhydrolase_1) | 5 | LEU A 225ALA A 247VAL A 456GLY A 510ILE A 509 | None | 1.27A | 3spkA-5uohA:undetectable | 3spkA-5uohA:12.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v7i | SERINEHYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL (Homo sapiens) |
no annotation | 5 | ARG A 425LEU A 381ASN A 379VAL A 354GLY A 257 | 8Z1 A 601 ( 3.8A)NoneNoneNoneNone | 1.14A | 3spkA-5v7iA:undetectable | 3spkA-5v7iA:12.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0s | 60 KDA CHAPERONIN (Escherichiacoli) |
PF00118(Cpn60_TCP1) | 5 | ALA A 143VAL A 407GLY A 148ILE A 150PRO A 496 | None | 1.14A | 3spkA-5w0sA:undetectable | 3spkA-5w0sA:12.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6o | SERINE/THREONINE-PROTEIN KINASE MEC1 (Saccharomycescerevisiae) |
no annotation | 5 | LEU C2112ALA C2211VAL C2239GLY C2217ILE C2219 | None | 1.14A | 3spkA-5x6oC:undetectable | 3spkA-5x6oC:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvi | GLUTAMATEDEHYDROGENASE (Aspergillusniger) |
no annotation | 5 | ARG A 34ALA A 450VAL A 40GLY A 445ILE A 443 | None | 1.22A | 3spkA-5xviA:undetectable | 3spkA-5xviA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bvg | PROTEIN-N(PI)-PHOSPHOHISTIDINE-SUGARPHOSPHOTRANSFERASE(ENZYME II OF THEPHOSPHOTRANSFERASESYSTEM) (PTS SYSTEMGLUCOSE-SPECIFICIIBC COMPONENT) (Bacillus cereus) |
no annotation | 5 | LEU A 156ALA A 90GLY A 146ILE A 148THR A 155 | None | 1.30A | 3spkA-6bvgA:undetectable | 3spkA-6bvgA:26.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ccz | SERINEHYDROXYMETHYLTRANSFERASE (Medicagotruncatula) |
no annotation | 5 | ARG A 454LEU A 410ASN A 408VAL A 383GLY A 295 | ACT A 612 (-2.9A)NoneSEY A 605 (-4.4A)NoneNone | 1.14A | 3spkA-6cczA:undetectable | 3spkA-6cczA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ezn | DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEINGLYCOSYLTRANSFERASESUBUNIT WBP1 (Saccharomycescerevisiae) |
no annotation | 5 | VAL G 118GLY G 233ILE G 232PRO G 83THR G 84 | None | 1.11A | 3spkA-6eznG:undetectable | 3spkA-6eznG:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fd2 | PUTATIVE APRAMYCINBIOSYNTHETICOXIDOREDUCTASE 4 (Streptoalloteichustenebrarius) |
no annotation | 5 | LEU B 152ALA B 108GLY B 126PRO B 155THR B 154 | None | 1.21A | 3spkA-6fd2B:undetectable | 3spkA-6fd2B:22.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | ARG A 8LEU A 23ALA A 28GLY A 49ILE A 50 | NoneNoneNIU A 100 (-3.6A)NIU A 100 ( 3.8A)NIU A 100 (-3.9A) | 0.76A | 3spkA-6upjA:18.3 | 3spkA-6upjA:47.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 7mdh | PROTEIN (MALATEDEHYDROGENASE) (Sorghum bicolor) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ASN A 314VAL A 309GLY A 227ILE A 352PRO A 327 | None | 1.33A | 3spkA-7mdhA:undetectable | 3spkA-7mdhA:15.64 |