SIMILAR PATTERNS OF AMINO ACIDS FOR 3SP9_A_IL2A901_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e51 | DELTA-AMINOLEVULINICACID DEHYDRATASE (Homo sapiens) |
PF00490(ALAD) | 5 | LEU A 61PHE A 79ILE A 314LEU A 73TYR A 196 | None | 1.15A | 3sp9A-1e51A:0.0 | 3sp9A-1e51A:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fiz | BETA-ACROSIN HEAVYCHAIN (Sus scrofa) |
PF00089(Trypsin) | 5 | THR A 231HIS A 91ILE A 103LEU A 47VAL A 250 | None | 1.28A | 3sp9A-1fizA:undetectable | 3sp9A-1fizA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gzg | DELTA-AMINOLEVULINICACID DEHYDRATASE (Pseudomonasaeruginosa) |
PF00490(ALAD) | 5 | LEU A 266PHE A 281THR A 323ILE A 80LEU A 33 | None | 1.19A | 3sp9A-1gzgA:0.0 | 3sp9A-1gzgA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hg3 | TRIOSEPHOSPHATEISOMERASE (Pyrococcuswoesei) |
PF00121(TIM)PF05690(ThiG) | 5 | THR A 120THR A 92ILE A 67LEU A 106VAL A 133 | None | 1.23A | 3sp9A-1hg3A:0.0 | 3sp9A-1hg3A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ikt | ESTRADIOL 17BETA-DEHYDROGENASE 4 (Homo sapiens) |
PF02036(SCP2) | 5 | THR A 70THR A 71HIS A 37LEU A 110VAL A 30 | NoneNoneNoneOXN A 123 ( 4.9A)None | 1.14A | 3sp9A-1iktA:undetectable | 3sp9A-1iktA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o7d | LYSOSOMALALPHA-MANNOSIDASE (Bos taurus) |
PF07748(Glyco_hydro_38C) | 5 | ILE D 782LEU D 804VAL D 771ILE D 730HIS D 842 | None | 1.14A | 3sp9A-1o7dD:undetectable | 3sp9A-1o7dD:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r53 | CHORISMATE SYNTHASE (Saccharomycescerevisiae) |
PF01264(Chorismate_synt) | 5 | LEU A 43CYH A 23THR A 12THR A 11LEU A 356 | None | 1.23A | 3sp9A-1r53A:0.0 | 3sp9A-1r53A:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s3i | 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE (Rattusnorvegicus) |
PF00551(Formyl_trans_N)PF02911(Formyl_trans_C) | 5 | LEU A 287PHE A 245THR A 235LEU A 261ILE A 292 | None | 1.26A | 3sp9A-1s3iA:undetectable | 3sp9A-1s3iA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t8w | AMP NUCLEOSIDASE (Escherichiacoli) |
PF01048(PNP_UDP_1)PF10423(AMNp_N) | 5 | LEU A 351THR A 204LEU A 453ILE A 273HIS A 264 | None | 0.97A | 3sp9A-1t8wA:0.0 | 3sp9A-1t8wA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vqt | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Thermotogamaritima) |
PF00215(OMPdecase) | 5 | LEU A 105PHE A 55ILE A 49LEU A 148VAL A 130 | NoneNoneNoneEDO A 204 (-4.9A)EDO A 204 ( 4.9A) | 1.20A | 3sp9A-1vqtA:undetectable | 3sp9A-1vqtA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xb2 | ELONGATION FACTORTS, MITOCHONDRIAL (Bos taurus) |
PF00889(EF_TS) | 5 | LEU B 297CYH B 253THR B 255LEU B 265VAL B 313 | None | 1.25A | 3sp9A-1xb2B:undetectable | 3sp9A-1xb2B:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvt | BETA-1,4-MANNANASE (Cellulomonasfimi) |
PF02156(Glyco_hydro_26) | 5 | LEU A 427THR A 392THR A 391LEU A 421ILE A 377 | None | 1.25A | 3sp9A-2bvtA:undetectable | 3sp9A-2bvtA:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ca4 | SULFITE:CYTOCHROME COXIDOREDUCTASESUBUNIT A (Starkeyanovella) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 5 | LEU A 89THR A 153ILE A 223LEU A 140VAL A 139 | None | 1.21A | 3sp9A-2ca4A:undetectable | 3sp9A-2ca4A:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d7s | RNA-DEPENDENT RNAPOLYMERASE (Foot-and-mouthdisease virus) |
PF00680(RdRP_1) | 5 | LEU A 85PHE A 257THR A 192HIS A 188ILE A 189 | None | 1.28A | 3sp9A-2d7sA:undetectable | 3sp9A-2d7sA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dhj | RHO GTPASEACTIVATING PROTEIN21 (Homo sapiens) |
PF15410(PH_9) | 5 | CYH A 71THR A 90THR A 89LEU A 47ILE A 112 | None | 1.30A | 3sp9A-2dhjA:undetectable | 3sp9A-2dhjA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fb5 | HYPOTHETICALMEMBRANE SPANNINGPROTEIN (Bacillus cereus) |
PF02457(DisA_N)PF10372(YojJ) | 5 | LEU A 118THR A 192LEU A 181VAL A 98ILE A 66 | None | 1.14A | 3sp9A-2fb5A:undetectable | 3sp9A-2fb5A:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gvk | HEME PEROXIDASE (Bacteroidesthetaiotaomicron) |
PF04261(Dyp_perox) | 5 | LEU A 314PHE A 303LEU A 131VAL A 41TYR A 261 | None | 1.30A | 3sp9A-2gvkA:undetectable | 3sp9A-2gvkA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hig | 6-PHOSPHO-1-FRUCTOKINASE (Trypanosomabrucei) |
PF00365(PFK) | 5 | LEU A 353CYH A 319LEU A 361VAL A 357HIS A 315 | None | 1.28A | 3sp9A-2higA:undetectable | 3sp9A-2higA:21.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p54 | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 247CYH A 276THR A 279ILE A 317ILE A 354 | None735 A 469 (-2.9A)735 A 469 (-3.6A)735 A 469 ( 4.8A)735 A 469 (-3.7A) | 1.07A | 3sp9A-2p54A:37.5 | 3sp9A-2p54A:70.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p54 | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 247PHE A 273CYH A 276THR A 279ILE A 317HIS A 440TYR A 464 | None735 A 469 (-3.7A)735 A 469 (-2.9A)735 A 469 (-3.6A)735 A 469 ( 4.8A)735 A 469 (-4.0A)735 A 469 (-4.6A) | 1.32A | 3sp9A-2p54A:37.5 | 3sp9A-2p54A:70.52 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p54 | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 258PHE A 273CYH A 276THR A 279ILE A 317HIS A 440TYR A 464 | None735 A 469 (-3.7A)735 A 469 (-2.9A)735 A 469 (-3.6A)735 A 469 ( 4.8A)735 A 469 (-4.0A)735 A 469 (-4.6A) | 1.27A | 3sp9A-2p54A:37.5 | 3sp9A-2p54A:70.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pa1 | PDZ AND LIM DOMAINPROTEIN 2 (Homo sapiens) |
PF00595(PDZ) | 5 | THR A 30LEU A 78VAL A 7ILE A 69HIS A 62 | None | 1.10A | 3sp9A-2pa1A:undetectable | 3sp9A-2pa1A:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pk3 | GDP-6-DEOXY-D-LYXO-4-HEXULOSE REDUCTASE (Aneurinibacillusthermoaerophilus) |
PF16363(GDP_Man_Dehyd) | 5 | LEU A 97THR A 165THR A 167HIS A 170ILE A 217 | NoneNoneNoneA2R A 401 ( 3.9A)None | 1.28A | 3sp9A-2pk3A:undetectable | 3sp9A-2pk3A:26.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pok | PEPTIDASE,M20/M25/M40 FAMILY (Streptococcuspneumoniae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | LEU A 232THR A 205ILE A 203LEU A 305ILE A 348 | None | 1.22A | 3sp9A-2pokA:undetectable | 3sp9A-2pokA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q30 | UNCHARACTERIZEDPROTEIN (Desulfovibrioalaskensis) |
PF07883(Cupin_2) | 5 | PHE A 37HIS A 50ILE A 87ILE A 58HIS A 48 | None | 1.13A | 3sp9A-2q30A:undetectable | 3sp9A-2q30A:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qmu | TRANSLATIONINITIATION FACTOR 2BETA SUBUNIT (Sulfolobussolfataricus) |
PF01873(eIF-5_eIF-2B) | 5 | LEU C 116CYH C 61ILE C 92LEU C 100VAL C 104 | None | 1.29A | 3sp9A-2qmuC:undetectable | 3sp9A-2qmuC:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qt3 | N-ISOPROPYLAMMELIDEISOPROPYLAMIDOHYDROLASE (Pseudomonas sp.ADP) |
PF01979(Amidohydro_1) | 5 | LEU A 298THR A 119LEU A 351VAL A 350HIS A 110 | None | 1.09A | 3sp9A-2qt3A:undetectable | 3sp9A-2qt3A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhl | N-ACETYLGLUCOSAMINE-6-PHOSPHATEDEACETYLASE (Bacillussubtilis) |
PF01979(Amidohydro_1) | 5 | THR A 250HIS A 63ILE A 279ILE A 197HIS A 134 | None FE A1397 (-3.3A)NoneNoneNone | 1.23A | 3sp9A-2vhlA:undetectable | 3sp9A-2vhlA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x2i | ALPHA-1,4-GLUCANLYASE ISOZYME 1 (Gracilariopsislemaneiformis) |
PF01055(Glyco_hydro_31) | 5 | PHE A 761CYH A 723ILE A 677LEU A 809ILE A 874 | None | 1.20A | 3sp9A-2x2iA:undetectable | 3sp9A-2x2iA:13.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x8a | NUCLEARVALOSIN-CONTAININGPROTEIN-LIKE (Homo sapiens) |
PF00004(AAA) | 5 | PHE A 679ILE A 730LEU A 705VAL A 663ILE A 720 | None | 1.19A | 3sp9A-2x8aA:undetectable | 3sp9A-2x8aA:24.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ya3 | 5'-AMP-ACTIVATEDPROTEIN KINASECATALYTIC SUBUNITALPHA-1 (Rattusnorvegicus) |
PF16579(AdenylateSensor) | 5 | PHE A 536CYH A 539ILE A 400LEU A 449VAL A 434 | None | 1.25A | 3sp9A-2ya3A:undetectable | 3sp9A-2ya3A:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yev | CYTOCHROME C OXIDASEPOLYPEPTIDE I+III (Thermusthermophilus) |
PF00115(COX1)PF00510(COX3) | 5 | LEU A 635PHE A 245THR A 252ILE A 83ILE A 160 | None | 1.25A | 3sp9A-2yevA:undetectable | 3sp9A-2yevA:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxx | DIAMINOPIMELATEDECARBOXYLASE (Thermotogamaritima) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 5 | PHE A 190LEU A 39VAL A 37ILE A 211HIS A 179 | NoneNoneNoneNonePLP A 401 (-3.6A) | 1.27A | 3sp9A-2yxxA:undetectable | 3sp9A-2yxxA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z0f | PUTATIVEPHOSPHOGLUCOMUTASE (Thermusthermophilus) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | LEU A 335PHE A 377THR A 316THR A 317LEU A 412 | None | 1.08A | 3sp9A-2z0fA:undetectable | 3sp9A-2z0fA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2u | UPF0026 PROTEINMJ0257 (Methanocaldococcusjannaschii) |
PF04055(Radical_SAM)PF08608(Wyosine_form) | 5 | LEU A 25THR A 159HIS A 153ILE A 149VAL A 23 | None | 1.29A | 3sp9A-2z2uA:undetectable | 3sp9A-2z2uA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zbl | PUTATIVE ISOMERASE (Salmonellaenterica) |
PF07221(GlcNAc_2-epim) | 5 | HIS A 386ILE A 390LEU A 328ILE A 250TYR A 382 | None | 1.26A | 3sp9A-2zblA:undetectable | 3sp9A-2zblA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zs0 | EXTRACELLULAR GIANTHEMOGLOBIN MAJORGLOBIN SUBUNIT B1 (Oligobrachiamashikoi) |
PF00042(Globin) | 5 | PHE D 36HIS D 96ILE D 141VAL D 118ILE D 69 | OXY D 201 (-4.5A)HEM D 200 (-3.3A)HEM D 200 (-4.5A)NoneNone | 1.30A | 3sp9A-2zs0D:undetectable | 3sp9A-2zs0D:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ztb | CRYSTAL PROTEIN (Bacillusthuringiensis) |
PF03318(ETX_MTX2) | 5 | THR A 192THR A 193LEU A 276VAL A 118ILE A 54 | None | 1.24A | 3sp9A-2ztbA:undetectable | 3sp9A-2ztbA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayx | MEMBRANE-BOUNDHYDROGENASE LARGESUBUNIT (Hydrogenovibriomarinus) |
PF00374(NiFeSe_Hases) | 5 | LEU A 114THR A 546THR A 547ILE A 398ILE A 75 | NoneCYN A 605 (-3.7A)NoneNoneNone | 1.18A | 3sp9A-3ayxA:undetectable | 3sp9A-3ayxA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ayx | MEMBRANE-BOUNDHYDROGENASE LARGESUBUNIT (Hydrogenovibriomarinus) |
PF00374(NiFeSe_Hases) | 5 | LEU A 114THR A 546THR A 547ILE A 398VAL A 78 | NoneCYN A 605 (-3.7A)NoneNone O A 609 ( 4.7A) | 1.23A | 3sp9A-3ayxA:undetectable | 3sp9A-3ayxA:17.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b0q | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | PHE A 282CYH A 285HIS A 323ILE A 326TYR A 473 | MC5 A 1 (-4.4A)MC5 A 1 (-3.6A)MC5 A 1 (-3.8A)MC5 A 1 ( 4.9A)MC5 A 1 (-4.9A) | 0.86A | 3sp9A-3b0qA:36.4 | 3sp9A-3b0qA:61.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b0q | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | PHE A 282CYH A 285ILE A 326HIS A 449TYR A 473 | MC5 A 1 (-4.4A)MC5 A 1 (-3.6A)MC5 A 1 ( 4.9A)MC5 A 1 (-3.9A)MC5 A 1 (-4.9A) | 1.19A | 3sp9A-3b0qA:36.4 | 3sp9A-3b0qA:61.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bz5 | INTERNALIN-J (Listeriamonocytogenes) |
PF12799(LRR_4) | 5 | LEU A 265CYH A 249ILE A 212VAL A 238ILE A 254 | None | 1.11A | 3sp9A-3bz5A:undetectable | 3sp9A-3bz5A:18.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d5f | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR DELTA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | LEU A 255PHE A 282CYH A 285THR A 288THR A 289HIS A 323ILE A 326LEU A 339VAL A 348ILE A 364HIS A 449TYR A 473 | NoneL41 A 501 ( 4.9A)L41 A 501 (-3.5A)L41 A 501 (-3.0A)L41 A 501 (-3.5A)L41 A 501 (-3.8A)NoneL41 A 501 (-4.8A)NoneL41 A 501 ( 4.2A)L41 A 501 (-3.9A)L41 A 501 (-4.8A) | 0.96A | 3sp9A-3d5fA:38.6 | 3sp9A-3d5fA:99.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dah | RIBOSE-PHOSPHATEPYROPHOSPHOKINASE (Burkholderiapseudomallei) |
PF13793(Pribosyltran_N)PF14572(Pribosyl_synth) | 5 | LEU A 26THR A 276HIS A 252VAL A 9ILE A 129 | None | 1.15A | 3sp9A-3dahA:undetectable | 3sp9A-3dahA:23.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 5 | LEU D 255PHE D 282ILE D 326HIS D 449TYR D 473 | NoneNonePLB D 701 ( 4.5A)NoneNone | 1.30A | 3sp9A-3dzuD:34.5 | 3sp9A-3dzuD:42.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e1k | GALACTOSE/LACTOSEMETABOLISMREGULATORY PROTEINGAL80 (Kluyveromyceslactis) |
PF01408(GFO_IDH_MocA) | 5 | THR A 35ILE A 315VAL A 91ILE A 384TYR A 374 | None | 1.25A | 3sp9A-3e1kA:undetectable | 3sp9A-3e1kA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fbt | CHORISMATE MUTASEAND SHIKIMATE5-DEHYDROGENASEFUSION PROTEIN (Clostridiumacetobutylicum) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | THR A 146ILE A 150LEU A 155VAL A 157ILE A 192 | None | 1.30A | 3sp9A-3fbtA:undetectable | 3sp9A-3fbtA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j7y | MS30 (Homo sapiens) |
PF00829(Ribosomal_L21p) | 5 | LEU s 118PHE s 367THR s 297LEU s 332ILE s 361 | None | 1.18A | 3sp9A-3j7ys:undetectable | 3sp9A-3j7ys:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jzy | INTERSECTIN 2 (Homo sapiens) |
PF00168(C2) | 5 | LEU A1604CYH A1566THR A1577ILE A1580VAL A1656 | NoneNoneUNX A 2 ( 4.7A)NoneNone | 1.29A | 3sp9A-3jzyA:undetectable | 3sp9A-3jzyA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lkd | TYPE IRESTRICTION-MODIFICATION SYSTEMMETHYLTRANSFERASESUBUNIT (Streptococcusthermophilus) |
PF02384(N6_Mtase)PF12161(HsdM_N) | 5 | LEU A 302ILE A 431LEU A 388VAL A 402ILE A 437 | None | 1.22A | 3sp9A-3lkdA:undetectable | 3sp9A-3lkdA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm5 | SERINE/THREONINE-PROTEIN KINASE 17B (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 64PHE A 180ILE A 118VAL A 47ILE A 94 | NoneNoneNoneQUE A 1 ( 4.6A)QUE A 1 (-4.6A) | 1.12A | 3sp9A-3lm5A:undetectable | 3sp9A-3lm5A:25.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3na6 | SUCCINYLGLUTAMATEDESUCCINYLASE/ASPARTOACYLASE (Ruegeria sp.TM1040) |
PF04952(AstE_AspA) | 5 | LEU A 232THR A 41ILE A 10VAL A 80TYR A 128 | None | 1.15A | 3sp9A-3na6A:undetectable | 3sp9A-3na6A:23.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ofj | NODULATION PROTEIN S (Bradyrhizobiumsp. WM9) |
PF05401(NodS) | 5 | LEU A 192THR A 59ILE A 92LEU A 110VAL A 144 | None | 1.27A | 3sp9A-3ofjA:undetectable | 3sp9A-3ofjA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3olz | GLUTAMATE RECEPTOR,IONOTROPIC KAINATE 3 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 5 | CYH A 202THR A 230THR A 229LEU A 236ILE A 210 | None | 1.17A | 3sp9A-3olzA:undetectable | 3sp9A-3olzA:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pv6 | IG-LIKEDOMAIN-CONTAININGPROTEINDKFZP686O24166/DKFZP686I21167 (Homo sapiens) |
PF07654(C1-set) | 5 | LEU A 147THR A 224THR A 181LEU A 215ILE A 190 | None | 1.12A | 3sp9A-3pv6A:undetectable | 3sp9A-3pv6A:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qi6 | CYSTATHIONINEGAMMA-SYNTHASE METB(CGS) (Mycobacteriumulcerans) |
PF01053(Cys_Met_Meta_PP) | 5 | CYH A 325THR A 328ILE A 332LEU A 369VAL A 312 | None | 1.24A | 3sp9A-3qi6A:undetectable | 3sp9A-3qi6A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qjg | EPIDERMINBIOSYNTHESIS PROTEINEPID (Staphylococcusaureus) |
PF02441(Flavoprotein) | 5 | CYH A 103ILE A 94LEU A 133VAL A 138ILE A 79 | None | 1.27A | 3sp9A-3qjgA:undetectable | 3sp9A-3qjgA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rgw | MEMBRANE-BOUNDHYDROGENASE (NIFE)LARGE SUBUNIT HOXG (Cupriavidusnecator) |
PF00374(NiFeSe_Hases) | 5 | LEU L 113THR L 553THR L 554ILE L 399ILE L 74 | NoneNFU L1004 (-3.8A)NoneNoneNone | 1.18A | 3sp9A-3rgwL:undetectable | 3sp9A-3rgwL:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ru6 | OROTIDINE5'-PHOSPHATEDECARBOXYLASE (Campylobacterjejuni) |
PF00215(OMPdecase) | 5 | LEU A 116PHE A 61ILE A 55LEU A 172VAL A 152 | IOD A 285 ( 4.8A)NoneNoneNoneNone | 1.25A | 3sp9A-3ru6A:undetectable | 3sp9A-3ru6A:25.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3usc | HYDROGENASE-1 LARGECHAIN (Escherichiacoli) |
PF00374(NiFeSe_Hases) | 5 | LEU L 114THR L 532THR L 533ILE L 398ILE L 75 | NoneFCO L 601 (-3.7A)NoneNoneNone | 1.15A | 3sp9A-3uscL:undetectable | 3sp9A-3uscL:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3usc | HYDROGENASE-1 LARGECHAIN (Escherichiacoli) |
PF00374(NiFeSe_Hases) | 5 | LEU L 114THR L 532THR L 533ILE L 398VAL L 78 | NoneFCO L 601 (-3.7A)NoneNone3NI L 602 ( 4.8A) | 1.20A | 3sp9A-3uscL:undetectable | 3sp9A-3uscL:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aca | TRANSLATIONELONGATION FACTORSELB (Methanococcusmaripaludis) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2) | 5 | LEU A 140THR A 172THR A 171LEU A 87ILE A 152 | None | 1.20A | 3sp9A-4acaA:undetectable | 3sp9A-4acaA:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4atb | INTERLEUKINENHANCER-BINDINGFACTOR 3 (Mus musculus) |
PF07528(DZF) | 5 | LEU B 207CYH B 116THR B 88ILE B 49VAL B 113 | None | 1.19A | 3sp9A-4atbB:undetectable | 3sp9A-4atbB:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3o | HYDROGENASE-1 LARGESUBUNIT (Salmonellaenterica) |
PF00374(NiFeSe_Hases) | 5 | LEU A 114THR A 535THR A 536ILE A 401ILE A 75 | NoneNFU A1004 (-3.7A)NoneNoneNone | 1.04A | 3sp9A-4c3oA:undetectable | 3sp9A-4c3oA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3o | HYDROGENASE-1 LARGESUBUNIT (Salmonellaenterica) |
PF00374(NiFeSe_Hases) | 5 | LEU A 114THR A 535THR A 536ILE A 401VAL A 78 | NoneNFU A1004 (-3.7A)NoneNoneNone | 1.13A | 3sp9A-4c3oA:undetectable | 3sp9A-4c3oA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cv5 | GENERAL NEGATIVEREGULATOR OFTRANSCRIPTIONSUBUNIT 1PROTEIN CAF40 (Saccharomycescerevisiae) |
PF04078(Rcd1)PF12842(DUF3819) | 5 | THR A1118ILE A1122LEU B 183VAL B 228ILE B 156 | None | 1.24A | 3sp9A-4cv5A:undetectable | 3sp9A-4cv5A:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dnh | UNCHARACTERIZEDPROTEIN (Sinorhizobiummeliloti) |
PF06187(DUF993) | 5 | LEU A 234CYH A 216THR A 215ILE A 173ILE A 189 | None | 1.27A | 3sp9A-4dnhA:undetectable | 3sp9A-4dnhA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e04 | BACTERIOPHYTOCHROME(LIGHT-REGULATEDSIGNAL TRANSDUCTIONHISTIDINE KINASE),PHYB1 (Rhodopseudomonaspalustris) |
PF01590(GAF)PF08446(PAS_2) | 5 | CYH A 285THR A 268HIS A 256ILE A 220VAL A 297 | NoneLBV A 400 (-3.4A)LBV A 400 (-3.5A)NoneNone | 1.30A | 3sp9A-4e04A:undetectable | 3sp9A-4e04A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e04 | BACTERIOPHYTOCHROME(LIGHT-REGULATEDSIGNAL TRANSDUCTIONHISTIDINE KINASE),PHYB1 (Rhodopseudomonaspalustris) |
PF01590(GAF)PF08446(PAS_2) | 5 | THR A 268HIS A 256ILE A 220VAL A 297ILE A 271 | LBV A 400 (-3.4A)LBV A 400 (-3.5A)NoneNoneNone | 1.18A | 3sp9A-4e04A:undetectable | 3sp9A-4e04A:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fgm | AMINOPEPTIDASE NFAMILY PROTEIN (Idiomarinaloihiensis) |
PF05299(Peptidase_M61)PF13180(PDZ_2) | 5 | PHE A 105THR A 109ILE A 164LEU A 125HIS A 239 | None | 0.99A | 3sp9A-4fgmA:undetectable | 3sp9A-4fgmA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fhn | NUCLEOPORIN NUP120 (Schizosaccharomycespombe) |
PF11715(Nup160) | 5 | LEU B 258THR B 292THR B 293ILE B 352ILE B 311 | None | 1.16A | 3sp9A-4fhnB:undetectable | 3sp9A-4fhnB:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gl2 | INTERFERON-INDUCEDHELICASE CDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 5 | CYH A 328THR A 488ILE A 814LEU A 509ILE A 858 | None | 1.29A | 3sp9A-4gl2A:undetectable | 3sp9A-4gl2A:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ln9 | RIFAMYCIN POLYKETIDESYNTHASE (Amycolatopsismediterranei) |
PF14765(PS-DH) | 5 | LEU A 260PHE A 212THR A 61LEU A 250VAL A 285 | None | 1.29A | 3sp9A-4ln9A:undetectable | 3sp9A-4ln9A:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o7i | 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE,PUTATIVE (Entamoebahistolytica) |
PF00459(Inositol_P) | 5 | LEU A 117CYH A 18THR A 21THR A 22ILE A 159 | None | 1.25A | 3sp9A-4o7iA:undetectable | 3sp9A-4o7iA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ol0 | TRANSPORTIN-3 (Homo sapiens) |
PF08389(Xpo1) | 5 | LEU B 232THR B 323ILE B 310LEU B 253VAL B 249 | None | 1.26A | 3sp9A-4ol0B:undetectable | 3sp9A-4ol0B:14.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oya | ADENYLATE CYCLASETYPE 10 (Homo sapiens) |
PF00211(Guanylate_cyc) | 5 | CYH A 122ILE A 115LEU A 147VAL A 187TYR A 240 | None | 1.19A | 3sp9A-4oyaA:undetectable | 3sp9A-4oyaA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pqi | IN2-1 FAMILYPROTEIN, GLUTATHIONETRANSFERASE LAMBDA3 (Populustrichocarpa) |
PF13410(GST_C_2)PF13417(GST_N_3) | 5 | LEU A 35PHE A 43CYH A 41THR A 40TYR A 139 | NoneGSH A 301 (-3.8A)GSH A 301 (-2.0A)NoneNone | 0.99A | 3sp9A-4pqiA:undetectable | 3sp9A-4pqiA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7y | MINICHROMOSOMEMAINTENANCE PROTEINMCM, CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus;Sulfolobussolfataricus) |
PF00493(MCM)PF14551(MCM_N)PF17207(MCM_OB) | 5 | THR A 19ILE A 31LEU A 45VAL A 98ILE A 82 | None | 1.20A | 3sp9A-4r7yA:undetectable | 3sp9A-4r7yA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uqg | DNA POLYMERASE (Geobacillusstearothermophilus) |
PF00476(DNA_pol_A) | 5 | LEU A 616THR A 765HIS A 664ILE A 665ILE A 657 | None | 1.29A | 3sp9A-4uqgA:undetectable | 3sp9A-4uqgA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xlg | STRUCTURE-SPECIFICENDONUCLEASE SUBUNITSLX1 ([Candida]glabrata) |
PF01541(GIY-YIG) | 5 | LEU A 118CYH A 13THR A 30ILE A 27HIS A 40 | None | 1.12A | 3sp9A-4xlgA:undetectable | 3sp9A-4xlgA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xr7 | PAB-DEPENDENTPOLY(A)-SPECIFICRIBONUCLEASE SUBUNITPAN3 (Saccharomycescerevisiae) |
no annotation | 5 | LEU L 373CYH L 446HIS L 417ILE L 413ILE L 349 | None | 1.29A | 3sp9A-4xr7L:undetectable | 3sp9A-4xr7L:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b25 | CALCIUM/CALMODULIN-DEPENDENT3',5'-CYCLICNUCLEOTIDEPHOSPHODIESTERASE 1B (Homo sapiens) |
PF00233(PDEase_I) | 5 | THR A 189ILE A 194LEU A 253VAL A 245TYR A 150 | None | 1.15A | 3sp9A-5b25A:undetectable | 3sp9A-5b25A:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cdj | RUBISCO LARGESUBUNIT-BINDINGPROTEIN SUBUNITALPHA, CHLOROPLASTIC (Chlamydomonasreinhardtii) |
PF00118(Cpn60_TCP1) | 5 | THR A 223ILE A 301LEU A 247VAL A 273ILE A 233 | None | 1.17A | 3sp9A-5cdjA:undetectable | 3sp9A-5cdjA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME, PUTATIVE (Plasmodiumfalciparum) |
PF00227(Proteasome) | 5 | THR H 87THR H 86ILE H 82LEU H 151ILE H 56 | None | 1.00A | 3sp9A-5fmgH:undetectable | 3sp9A-5fmgH:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gn1 | ATP-DEPENDENTHELICASE FUN30 (Saccharomycescerevisiae) |
PF00176(SNF2_N)PF00271(Helicase_C) | 5 | THR A1072HIS A1084ILE A1074LEU A 876VAL A 978 | None | 1.19A | 3sp9A-5gn1A:undetectable | 3sp9A-5gn1A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hy5 | TRYPTOPHAN6-HALOGENASE (Streptomycestoxytricini) |
PF04820(Trp_halogenase) | 5 | LEU A 146PHE A 98THR A 279ILE A 292ILE A 56 | None | 1.25A | 3sp9A-5hy5A:undetectable | 3sp9A-5hy5A:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6h | ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 5 | LEU A1436VAL A1432ILE A1457HIS A1416TYR A1525 | None | 1.21A | 3sp9A-5i6hA:undetectable | 3sp9A-5i6hA:11.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6i | ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN,ACETYL-COACARBOXYLASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01039(Carboxyl_trans)PF08326(ACC_central) | 5 | LEU A1436VAL A1432ILE A1457HIS A1416TYR A1525 | None | 1.22A | 3sp9A-5i6iA:undetectable | 3sp9A-5i6iA:8.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ip9 | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB2 (Saccharomycescerevisiae) |
PF00562(RNA_pol_Rpb2_6)PF00623(RNA_pol_Rpb1_2)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | LEU B 661HIS A 786ILE B 703LEU B 651VAL B 653 | None | 1.29A | 3sp9A-5ip9B:undetectable | 3sp9A-5ip9B:13.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j44 | SERINE PROTEASE SEPAAUTOTRANSPORTER (Shigellaflexneri) |
PF02395(Peptidase_S6) | 5 | THR A 619THR A 620HIS A 611ILE A 614HIS A 566 | None | 1.25A | 3sp9A-5j44A:undetectable | 3sp9A-5j44A:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j4r | WELO5 (Hapalosiphonwelwitschii) |
no annotation | 5 | THR A 151ILE A 84LEU A 59VAL A 55TYR A 99 | None | 1.10A | 3sp9A-5j4rA:undetectable | 3sp9A-5j4rA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mxp | - (-) |
no annotation | 5 | PHE A 169THR A 42HIS A 104LEU A 187HIS A 273 | ACT A 401 (-4.5A)NoneNoneNoneACT A 401 ( 4.3A) | 1.18A | 3sp9A-5mxpA:undetectable | 3sp9A-5mxpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5us1 | AMINOGLYCOSIDE2'-N-ACETYLTRANSFERASE (Providenciastuartii) |
PF13673(Acetyltransf_10) | 5 | LEU A 13THR A 100ILE A 104ILE A 62TYR A 123 | None | 1.27A | 3sp9A-5us1A:undetectable | 3sp9A-5us1A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v1b | EGL NINE HOMOLOG 2 (Homo sapiens) |
PF13640(2OG-FeII_Oxy_3) | 5 | PHE A 350CYH A 310THR A 371VAL A 263ILE A 308 | None | 1.18A | 3sp9A-5v1bA:undetectable | 3sp9A-5v1bA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wjm | CADHERIN-23 (Mus musculus) |
no annotation | 5 | LEU A1891PHE A1877LEU A1922VAL A1924ILE A1867 | NoneMPD A2009 (-3.7A)NoneNoneNone | 0.96A | 3sp9A-5wjmA:undetectable | 3sp9A-5wjmA:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zal | ENDORIBONUCLEASEDICER (Homo sapiens) |
no annotation | 5 | CYH A 63THR A 206HIS A 178VAL A 594ILE A 223 | None | 1.23A | 3sp9A-5zalA:undetectable | 3sp9A-5zalA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6etz | BETA-GALACTOSIDASE (Arthrobactersp. 32cB) |
no annotation | 5 | ILE A 152LEU A 35VAL A 122ILE A 128HIS A 131 | None | 1.25A | 3sp9A-6etzA:undetectable | 3sp9A-6etzA:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fuz | KINESIN LIGHT CHAIN1,KINESIN LIGHTCHAIN1,C-JUN-AMINO-TERMINALKINASE-INTERACTINGPROTEIN 1NANOBODY (Homo sapiens;Lama;Mus musculus) |
no annotation | 5 | PHE N 27THR N 53ILE N 51LEU A 366VAL A 380 | None | 0.90A | 3sp9A-6fuzN:undetectable | 3sp9A-6fuzN:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gpc | - (-) |
no annotation | 5 | LEU A 46ILE A 78LEU A 123VAL A 122ILE A 73 | None | 1.28A | 3sp9A-6gpcA:undetectable | 3sp9A-6gpcA:undetectable |