SIMILAR PATTERNS OF AMINO ACIDS FOR 3SP9_A_IL2A901_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE


(Homo sapiens)
PF00490
(ALAD)
5 LEU A  61
PHE A  79
ILE A 314
LEU A  73
TYR A 196
None
1.15A 3sp9A-1e51A:
0.0
3sp9A-1e51A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN


(Sus scrofa)
PF00089
(Trypsin)
5 THR A 231
HIS A  91
ILE A 103
LEU A  47
VAL A 250
None
1.28A 3sp9A-1fizA:
undetectable
3sp9A-1fizA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE


(Pseudomonas
aeruginosa)
PF00490
(ALAD)
5 LEU A 266
PHE A 281
THR A 323
ILE A  80
LEU A  33
None
1.19A 3sp9A-1gzgA:
0.0
3sp9A-1gzgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg3 TRIOSEPHOSPHATE
ISOMERASE


(Pyrococcus
woesei)
PF00121
(TIM)
PF05690
(ThiG)
5 THR A 120
THR A  92
ILE A  67
LEU A 106
VAL A 133
None
1.23A 3sp9A-1hg3A:
0.0
3sp9A-1hg3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikt ESTRADIOL 17
BETA-DEHYDROGENASE 4


(Homo sapiens)
PF02036
(SCP2)
5 THR A  70
THR A  71
HIS A  37
LEU A 110
VAL A  30
None
None
None
OXN  A 123 ( 4.9A)
None
1.14A 3sp9A-1iktA:
undetectable
3sp9A-1iktA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE


(Bos taurus)
PF07748
(Glyco_hydro_38C)
5 ILE D 782
LEU D 804
VAL D 771
ILE D 730
HIS D 842
None
1.14A 3sp9A-1o7dD:
undetectable
3sp9A-1o7dD:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r53 CHORISMATE SYNTHASE

(Saccharomyces
cerevisiae)
PF01264
(Chorismate_synt)
5 LEU A  43
CYH A  23
THR A  12
THR A  11
LEU A 356
None
1.23A 3sp9A-1r53A:
0.0
3sp9A-1r53A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3i 10-FORMYLTETRAHYDROF
OLATE DEHYDROGENASE


(Rattus
norvegicus)
PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C)
5 LEU A 287
PHE A 245
THR A 235
LEU A 261
ILE A 292
None
1.26A 3sp9A-1s3iA:
undetectable
3sp9A-1s3iA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8w AMP NUCLEOSIDASE

(Escherichia
coli)
PF01048
(PNP_UDP_1)
PF10423
(AMNp_N)
5 LEU A 351
THR A 204
LEU A 453
ILE A 273
HIS A 264
None
0.97A 3sp9A-1t8wA:
0.0
3sp9A-1t8wA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE


(Thermotoga
maritima)
PF00215
(OMPdecase)
5 LEU A 105
PHE A  55
ILE A  49
LEU A 148
VAL A 130
None
None
None
EDO  A 204 (-4.9A)
EDO  A 204 ( 4.9A)
1.20A 3sp9A-1vqtA:
undetectable
3sp9A-1vqtA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb2 ELONGATION FACTOR
TS, MITOCHONDRIAL


(Bos taurus)
PF00889
(EF_TS)
5 LEU B 297
CYH B 253
THR B 255
LEU B 265
VAL B 313
None
1.25A 3sp9A-1xb2B:
undetectable
3sp9A-1xb2B:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvt BETA-1,4-MANNANASE

(Cellulomonas
fimi)
PF02156
(Glyco_hydro_26)
5 LEU A 427
THR A 392
THR A 391
LEU A 421
ILE A 377
None
1.25A 3sp9A-2bvtA:
undetectable
3sp9A-2bvtA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ca4 SULFITE:CYTOCHROME C
OXIDOREDUCTASE
SUBUNIT A


(Starkeya
novella)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
5 LEU A  89
THR A 153
ILE A 223
LEU A 140
VAL A 139
None
1.21A 3sp9A-2ca4A:
undetectable
3sp9A-2ca4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE


(Foot-and-mouth
disease virus)
PF00680
(RdRP_1)
5 LEU A  85
PHE A 257
THR A 192
HIS A 188
ILE A 189
None
1.28A 3sp9A-2d7sA:
undetectable
3sp9A-2d7sA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhj RHO GTPASE
ACTIVATING PROTEIN
21


(Homo sapiens)
PF15410
(PH_9)
5 CYH A  71
THR A  90
THR A  89
LEU A  47
ILE A 112
None
1.30A 3sp9A-2dhjA:
undetectable
3sp9A-2dhjA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fb5 HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN


(Bacillus cereus)
PF02457
(DisA_N)
PF10372
(YojJ)
5 LEU A 118
THR A 192
LEU A 181
VAL A  98
ILE A  66
None
1.14A 3sp9A-2fb5A:
undetectable
3sp9A-2fb5A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvk HEME PEROXIDASE

(Bacteroides
thetaiotaomicron)
PF04261
(Dyp_perox)
5 LEU A 314
PHE A 303
LEU A 131
VAL A  41
TYR A 261
None
1.30A 3sp9A-2gvkA:
undetectable
3sp9A-2gvkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE


(Trypanosoma
brucei)
PF00365
(PFK)
5 LEU A 353
CYH A 319
LEU A 361
VAL A 357
HIS A 315
None
1.28A 3sp9A-2higA:
undetectable
3sp9A-2higA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 247
CYH A 276
THR A 279
ILE A 317
ILE A 354
None
735  A 469 (-2.9A)
735  A 469 (-3.6A)
735  A 469 ( 4.8A)
735  A 469 (-3.7A)
1.07A 3sp9A-2p54A:
37.5
3sp9A-2p54A:
70.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 247
PHE A 273
CYH A 276
THR A 279
ILE A 317
HIS A 440
TYR A 464
None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-3.6A)
735  A 469 ( 4.8A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
1.32A 3sp9A-2p54A:
37.5
3sp9A-2p54A:
70.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
7 LEU A 258
PHE A 273
CYH A 276
THR A 279
ILE A 317
HIS A 440
TYR A 464
None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-3.6A)
735  A 469 ( 4.8A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
1.27A 3sp9A-2p54A:
37.5
3sp9A-2p54A:
70.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa1 PDZ AND LIM DOMAIN
PROTEIN 2


(Homo sapiens)
PF00595
(PDZ)
5 THR A  30
LEU A  78
VAL A   7
ILE A  69
HIS A  62
None
1.10A 3sp9A-2pa1A:
undetectable
3sp9A-2pa1A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk3 GDP-6-DEOXY-D-LYXO-4
-HEXULOSE REDUCTASE


(Aneurinibacillus
thermoaerophilus)
PF16363
(GDP_Man_Dehyd)
5 LEU A  97
THR A 165
THR A 167
HIS A 170
ILE A 217
None
None
None
A2R  A 401 ( 3.9A)
None
1.28A 3sp9A-2pk3A:
undetectable
3sp9A-2pk3A:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY


(Streptococcus
pneumoniae)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 LEU A 232
THR A 205
ILE A 203
LEU A 305
ILE A 348
None
1.22A 3sp9A-2pokA:
undetectable
3sp9A-2pokA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q30 UNCHARACTERIZED
PROTEIN


(Desulfovibrio
alaskensis)
PF07883
(Cupin_2)
5 PHE A  37
HIS A  50
ILE A  87
ILE A  58
HIS A  48
None
1.13A 3sp9A-2q30A:
undetectable
3sp9A-2q30A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmu TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT


(Sulfolobus
solfataricus)
PF01873
(eIF-5_eIF-2B)
5 LEU C 116
CYH C  61
ILE C  92
LEU C 100
VAL C 104
None
1.29A 3sp9A-2qmuC:
undetectable
3sp9A-2qmuC:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE


(Pseudomonas sp.
ADP)
PF01979
(Amidohydro_1)
5 LEU A 298
THR A 119
LEU A 351
VAL A 350
HIS A 110
None
1.09A 3sp9A-2qt3A:
undetectable
3sp9A-2qt3A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE


(Bacillus
subtilis)
PF01979
(Amidohydro_1)
5 THR A 250
HIS A  63
ILE A 279
ILE A 197
HIS A 134
None
FE  A1397 (-3.3A)
None
None
None
1.23A 3sp9A-2vhlA:
undetectable
3sp9A-2vhlA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1


(Gracilariopsis
lemaneiformis)
PF01055
(Glyco_hydro_31)
5 PHE A 761
CYH A 723
ILE A 677
LEU A 809
ILE A 874
None
1.20A 3sp9A-2x2iA:
undetectable
3sp9A-2x2iA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE


(Homo sapiens)
PF00004
(AAA)
5 PHE A 679
ILE A 730
LEU A 705
VAL A 663
ILE A 720
None
1.19A 3sp9A-2x8aA:
undetectable
3sp9A-2x8aA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya3 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1


(Rattus
norvegicus)
PF16579
(AdenylateSensor)
5 PHE A 536
CYH A 539
ILE A 400
LEU A 449
VAL A 434
None
1.25A 3sp9A-2ya3A:
undetectable
3sp9A-2ya3A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III


(Thermus
thermophilus)
PF00115
(COX1)
PF00510
(COX3)
5 LEU A 635
PHE A 245
THR A 252
ILE A  83
ILE A 160
None
1.25A 3sp9A-2yevA:
undetectable
3sp9A-2yevA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxx DIAMINOPIMELATE
DECARBOXYLASE


(Thermotoga
maritima)
PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N)
5 PHE A 190
LEU A  39
VAL A  37
ILE A 211
HIS A 179
None
None
None
None
PLP  A 401 (-3.6A)
1.27A 3sp9A-2yxxA:
undetectable
3sp9A-2yxxA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE


(Thermus
thermophilus)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
5 LEU A 335
PHE A 377
THR A 316
THR A 317
LEU A 412
None
1.08A 3sp9A-2z0fA:
undetectable
3sp9A-2z0fA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2u UPF0026 PROTEIN
MJ0257


(Methanocaldococcus
jannaschii)
PF04055
(Radical_SAM)
PF08608
(Wyosine_form)
5 LEU A  25
THR A 159
HIS A 153
ILE A 149
VAL A  23
None
1.29A 3sp9A-2z2uA:
undetectable
3sp9A-2z2uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica)
PF07221
(GlcNAc_2-epim)
5 HIS A 386
ILE A 390
LEU A 328
ILE A 250
TYR A 382
None
1.26A 3sp9A-2zblA:
undetectable
3sp9A-2zblA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zs0 EXTRACELLULAR GIANT
HEMOGLOBIN MAJOR
GLOBIN SUBUNIT B1


(Oligobrachia
mashikoi)
PF00042
(Globin)
5 PHE D  36
HIS D  96
ILE D 141
VAL D 118
ILE D  69
OXY  D 201 (-4.5A)
HEM  D 200 (-3.3A)
HEM  D 200 (-4.5A)
None
None
1.30A 3sp9A-2zs0D:
undetectable
3sp9A-2zs0D:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztb CRYSTAL PROTEIN

(Bacillus
thuringiensis)
PF03318
(ETX_MTX2)
5 THR A 192
THR A 193
LEU A 276
VAL A 118
ILE A  54
None
1.24A 3sp9A-2ztbA:
undetectable
3sp9A-2ztbA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT


(Hydrogenovibrio
marinus)
PF00374
(NiFeSe_Hases)
5 LEU A 114
THR A 546
THR A 547
ILE A 398
ILE A  75
None
CYN  A 605 (-3.7A)
None
None
None
1.18A 3sp9A-3ayxA:
undetectable
3sp9A-3ayxA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT


(Hydrogenovibrio
marinus)
PF00374
(NiFeSe_Hases)
5 LEU A 114
THR A 546
THR A 547
ILE A 398
VAL A  78
None
CYN  A 605 (-3.7A)
None
None
O  A 609 ( 4.7A)
1.23A 3sp9A-3ayxA:
undetectable
3sp9A-3ayxA:
17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
5 PHE A 282
CYH A 285
HIS A 323
ILE A 326
TYR A 473
MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
MC5  A   1 (-3.8A)
MC5  A   1 ( 4.9A)
MC5  A   1 (-4.9A)
0.86A 3sp9A-3b0qA:
36.4
3sp9A-3b0qA:
61.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
5 PHE A 282
CYH A 285
ILE A 326
HIS A 449
TYR A 473
MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
MC5  A   1 ( 4.9A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.9A)
1.19A 3sp9A-3b0qA:
36.4
3sp9A-3b0qA:
61.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes)
PF12799
(LRR_4)
5 LEU A 265
CYH A 249
ILE A 212
VAL A 238
ILE A 254
None
1.11A 3sp9A-3bz5A:
undetectable
3sp9A-3bz5A:
18.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA


(Homo sapiens)
PF00104
(Hormone_recep)
12 LEU A 255
PHE A 282
CYH A 285
THR A 288
THR A 289
HIS A 323
ILE A 326
LEU A 339
VAL A 348
ILE A 364
HIS A 449
TYR A 473
None
L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.0A)
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
None
L41  A 501 (-4.8A)
None
L41  A 501 ( 4.2A)
L41  A 501 (-3.9A)
L41  A 501 (-4.8A)
0.96A 3sp9A-3d5fA:
38.6
3sp9A-3d5fA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE


(Burkholderia
pseudomallei)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
5 LEU A  26
THR A 276
HIS A 252
VAL A   9
ILE A 129
None
1.15A 3sp9A-3dahA:
undetectable
3sp9A-3dahA:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
5 LEU D 255
PHE D 282
ILE D 326
HIS D 449
TYR D 473
None
None
PLB  D 701 ( 4.5A)
None
None
1.30A 3sp9A-3dzuD:
34.5
3sp9A-3dzuD:
42.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80


(Kluyveromyces
lactis)
PF01408
(GFO_IDH_MocA)
5 THR A  35
ILE A 315
VAL A  91
ILE A 384
TYR A 374
None
1.25A 3sp9A-3e1kA:
undetectable
3sp9A-3e1kA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbt CHORISMATE MUTASE
AND SHIKIMATE
5-DEHYDROGENASE
FUSION PROTEIN


(Clostridium
acetobutylicum)
PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N)
5 THR A 146
ILE A 150
LEU A 155
VAL A 157
ILE A 192
None
1.30A 3sp9A-3fbtA:
undetectable
3sp9A-3fbtA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y MS30

(Homo sapiens)
PF00829
(Ribosomal_L21p)
5 LEU s 118
PHE s 367
THR s 297
LEU s 332
ILE s 361
None
1.18A 3sp9A-3j7ys:
undetectable
3sp9A-3j7ys:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzy INTERSECTIN 2

(Homo sapiens)
PF00168
(C2)
5 LEU A1604
CYH A1566
THR A1577
ILE A1580
VAL A1656
None
None
UNX  A   2 ( 4.7A)
None
None
1.29A 3sp9A-3jzyA:
undetectable
3sp9A-3jzyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT


(Streptococcus
thermophilus)
PF02384
(N6_Mtase)
PF12161
(HsdM_N)
5 LEU A 302
ILE A 431
LEU A 388
VAL A 402
ILE A 437
None
1.22A 3sp9A-3lkdA:
undetectable
3sp9A-3lkdA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A  64
PHE A 180
ILE A 118
VAL A  47
ILE A  94
None
None
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.6A)
1.12A 3sp9A-3lm5A:
undetectable
3sp9A-3lm5A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na6 SUCCINYLGLUTAMATE
DESUCCINYLASE/ASPART
OACYLASE


(Ruegeria sp.
TM1040)
PF04952
(AstE_AspA)
5 LEU A 232
THR A  41
ILE A  10
VAL A  80
TYR A 128
None
1.15A 3sp9A-3na6A:
undetectable
3sp9A-3na6A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofj NODULATION PROTEIN S

(Bradyrhizobium
sp. WM9)
PF05401
(NodS)
5 LEU A 192
THR A  59
ILE A  92
LEU A 110
VAL A 144
None
1.27A 3sp9A-3ofjA:
undetectable
3sp9A-3ofjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3


(Rattus
norvegicus)
PF01094
(ANF_receptor)
5 CYH A 202
THR A 230
THR A 229
LEU A 236
ILE A 210
None
1.17A 3sp9A-3olzA:
undetectable
3sp9A-3olzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167


(Homo sapiens)
PF07654
(C1-set)
5 LEU A 147
THR A 224
THR A 181
LEU A 215
ILE A 190
None
1.12A 3sp9A-3pv6A:
undetectable
3sp9A-3pv6A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)


(Mycobacterium
ulcerans)
PF01053
(Cys_Met_Meta_PP)
5 CYH A 325
THR A 328
ILE A 332
LEU A 369
VAL A 312
None
1.24A 3sp9A-3qi6A:
undetectable
3sp9A-3qi6A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjg EPIDERMIN
BIOSYNTHESIS PROTEIN
EPID


(Staphylococcus
aureus)
PF02441
(Flavoprotein)
5 CYH A 103
ILE A  94
LEU A 133
VAL A 138
ILE A  79
None
1.27A 3sp9A-3qjgA:
undetectable
3sp9A-3qjgA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG


(Cupriavidus
necator)
PF00374
(NiFeSe_Hases)
5 LEU L 113
THR L 553
THR L 554
ILE L 399
ILE L  74
None
NFU  L1004 (-3.8A)
None
None
None
1.18A 3sp9A-3rgwL:
undetectable
3sp9A-3rgwL:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE


(Campylobacter
jejuni)
PF00215
(OMPdecase)
5 LEU A 116
PHE A  61
ILE A  55
LEU A 172
VAL A 152
IOD  A 285 ( 4.8A)
None
None
None
None
1.25A 3sp9A-3ru6A:
undetectable
3sp9A-3ru6A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN


(Escherichia
coli)
PF00374
(NiFeSe_Hases)
5 LEU L 114
THR L 532
THR L 533
ILE L 398
ILE L  75
None
FCO  L 601 (-3.7A)
None
None
None
1.15A 3sp9A-3uscL:
undetectable
3sp9A-3uscL:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usc HYDROGENASE-1 LARGE
CHAIN


(Escherichia
coli)
PF00374
(NiFeSe_Hases)
5 LEU L 114
THR L 532
THR L 533
ILE L 398
VAL L  78
None
FCO  L 601 (-3.7A)
None
None
3NI  L 602 ( 4.8A)
1.20A 3sp9A-3uscL:
undetectable
3sp9A-3uscL:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aca TRANSLATION
ELONGATION FACTOR
SELB


(Methanococcus
maripaludis)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
5 LEU A 140
THR A 172
THR A 171
LEU A  87
ILE A 152
None
1.20A 3sp9A-4acaA:
undetectable
3sp9A-4acaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3


(Mus musculus)
PF07528
(DZF)
5 LEU B 207
CYH B 116
THR B  88
ILE B  49
VAL B 113
None
1.19A 3sp9A-4atbB:
undetectable
3sp9A-4atbB:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT


(Salmonella
enterica)
PF00374
(NiFeSe_Hases)
5 LEU A 114
THR A 535
THR A 536
ILE A 401
ILE A  75
None
NFU  A1004 (-3.7A)
None
None
None
1.04A 3sp9A-4c3oA:
undetectable
3sp9A-4c3oA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT


(Salmonella
enterica)
PF00374
(NiFeSe_Hases)
5 LEU A 114
THR A 535
THR A 536
ILE A 401
VAL A  78
None
NFU  A1004 (-3.7A)
None
None
None
1.13A 3sp9A-4c3oA:
undetectable
3sp9A-4c3oA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
PROTEIN CAF40


(Saccharomyces
cerevisiae)
PF04078
(Rcd1)
PF12842
(DUF3819)
5 THR A1118
ILE A1122
LEU B 183
VAL B 228
ILE B 156
None
1.24A 3sp9A-4cv5A:
undetectable
3sp9A-4cv5A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN


(Sinorhizobium
meliloti)
PF06187
(DUF993)
5 LEU A 234
CYH A 216
THR A 215
ILE A 173
ILE A 189
None
1.27A 3sp9A-4dnhA:
undetectable
3sp9A-4dnhA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1


(Rhodopseudomonas
palustris)
PF01590
(GAF)
PF08446
(PAS_2)
5 CYH A 285
THR A 268
HIS A 256
ILE A 220
VAL A 297
None
LBV  A 400 (-3.4A)
LBV  A 400 (-3.5A)
None
None
1.30A 3sp9A-4e04A:
undetectable
3sp9A-4e04A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1


(Rhodopseudomonas
palustris)
PF01590
(GAF)
PF08446
(PAS_2)
5 THR A 268
HIS A 256
ILE A 220
VAL A 297
ILE A 271
LBV  A 400 (-3.4A)
LBV  A 400 (-3.5A)
None
None
None
1.18A 3sp9A-4e04A:
undetectable
3sp9A-4e04A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN


(Idiomarina
loihiensis)
PF05299
(Peptidase_M61)
PF13180
(PDZ_2)
5 PHE A 105
THR A 109
ILE A 164
LEU A 125
HIS A 239
None
0.99A 3sp9A-4fgmA:
undetectable
3sp9A-4fgmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe)
PF11715
(Nup160)
5 LEU B 258
THR B 292
THR B 293
ILE B 352
ILE B 311
None
1.16A 3sp9A-4fhnB:
undetectable
3sp9A-4fhnB:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD)
5 CYH A 328
THR A 488
ILE A 814
LEU A 509
ILE A 858
None
1.29A 3sp9A-4gl2A:
undetectable
3sp9A-4gl2A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE


(Amycolatopsis
mediterranei)
PF14765
(PS-DH)
5 LEU A 260
PHE A 212
THR A  61
LEU A 250
VAL A 285
None
1.29A 3sp9A-4ln9A:
undetectable
3sp9A-4ln9A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7i 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE


(Entamoeba
histolytica)
PF00459
(Inositol_P)
5 LEU A 117
CYH A  18
THR A  21
THR A  22
ILE A 159
None
1.25A 3sp9A-4o7iA:
undetectable
3sp9A-4o7iA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens)
PF08389
(Xpo1)
5 LEU B 232
THR B 323
ILE B 310
LEU B 253
VAL B 249
None
1.26A 3sp9A-4ol0B:
undetectable
3sp9A-4ol0B:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10


(Homo sapiens)
PF00211
(Guanylate_cyc)
5 CYH A 122
ILE A 115
LEU A 147
VAL A 187
TYR A 240
None
1.19A 3sp9A-4oyaA:
undetectable
3sp9A-4oyaA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3


(Populus
trichocarpa)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
5 LEU A  35
PHE A  43
CYH A  41
THR A  40
TYR A 139
None
GSH  A 301 (-3.8A)
GSH  A 301 (-2.0A)
None
None
0.99A 3sp9A-4pqiA:
undetectable
3sp9A-4pqiA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21


(Pyrococcus
furiosus;
Sulfolobus
solfataricus)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
5 THR A  19
ILE A  31
LEU A  45
VAL A  98
ILE A  82
None
1.20A 3sp9A-4r7yA:
undetectable
3sp9A-4r7yA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus)
PF00476
(DNA_pol_A)
5 LEU A 616
THR A 765
HIS A 664
ILE A 665
ILE A 657
None
1.29A 3sp9A-4uqgA:
undetectable
3sp9A-4uqgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xlg STRUCTURE-SPECIFIC
ENDONUCLEASE SUBUNIT
SLX1


([Candida]
glabrata)
PF01541
(GIY-YIG)
5 LEU A 118
CYH A  13
THR A  30
ILE A  27
HIS A  40
None
1.12A 3sp9A-4xlgA:
undetectable
3sp9A-4xlgA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3


(Saccharomyces
cerevisiae)
no annotation 5 LEU L 373
CYH L 446
HIS L 417
ILE L 413
ILE L 349
None
1.29A 3sp9A-4xr7L:
undetectable
3sp9A-4xr7L:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B


(Homo sapiens)
PF00233
(PDEase_I)
5 THR A 189
ILE A 194
LEU A 253
VAL A 245
TYR A 150
None
1.15A 3sp9A-5b25A:
undetectable
3sp9A-5b25A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdj RUBISCO LARGE
SUBUNIT-BINDING
PROTEIN SUBUNIT
ALPHA, CHLOROPLASTIC


(Chlamydomonas
reinhardtii)
PF00118
(Cpn60_TCP1)
5 THR A 223
ILE A 301
LEU A 247
VAL A 273
ILE A 233
None
1.17A 3sp9A-5cdjA:
undetectable
3sp9A-5cdjA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME, PUTATIVE

(Plasmodium
falciparum)
PF00227
(Proteasome)
5 THR H  87
THR H  86
ILE H  82
LEU H 151
ILE H  56
None
1.00A 3sp9A-5fmgH:
undetectable
3sp9A-5fmgH:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn1 ATP-DEPENDENT
HELICASE FUN30


(Saccharomyces
cerevisiae)
PF00176
(SNF2_N)
PF00271
(Helicase_C)
5 THR A1072
HIS A1084
ILE A1074
LEU A 876
VAL A 978
None
1.19A 3sp9A-5gn1A:
undetectable
3sp9A-5gn1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE


(Streptomyces
toxytricini)
PF04820
(Trp_halogenase)
5 LEU A 146
PHE A  98
THR A 279
ILE A 292
ILE A  56
None
1.25A 3sp9A-5hy5A:
undetectable
3sp9A-5hy5A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
5 LEU A1436
VAL A1432
ILE A1457
HIS A1416
TYR A1525
None
1.21A 3sp9A-5i6hA:
undetectable
3sp9A-5i6hA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF01039
(Carboxyl_trans)
PF08326
(ACC_central)
5 LEU A1436
VAL A1432
ILE A1457
HIS A1416
TYR A1525
None
1.22A 3sp9A-5i6iA:
undetectable
3sp9A-5i6iA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2


(Saccharomyces
cerevisiae)
PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 LEU B 661
HIS A 786
ILE B 703
LEU B 651
VAL B 653
None
1.29A 3sp9A-5ip9B:
undetectable
3sp9A-5ip9B:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER


(Shigella
flexneri)
PF02395
(Peptidase_S6)
5 THR A 619
THR A 620
HIS A 611
ILE A 614
HIS A 566
None
1.25A 3sp9A-5j44A:
undetectable
3sp9A-5j44A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii)
no annotation 5 THR A 151
ILE A  84
LEU A  59
VAL A  55
TYR A  99
None
1.10A 3sp9A-5j4rA:
undetectable
3sp9A-5j4rA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxp -

(-)
no annotation 5 PHE A 169
THR A  42
HIS A 104
LEU A 187
HIS A 273
ACT  A 401 (-4.5A)
None
None
None
ACT  A 401 ( 4.3A)
1.18A 3sp9A-5mxpA:
undetectable
3sp9A-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5us1 AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE


(Providencia
stuartii)
PF13673
(Acetyltransf_10)
5 LEU A  13
THR A 100
ILE A 104
ILE A  62
TYR A 123
None
1.27A 3sp9A-5us1A:
undetectable
3sp9A-5us1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1b EGL NINE HOMOLOG 2

(Homo sapiens)
PF13640
(2OG-FeII_Oxy_3)
5 PHE A 350
CYH A 310
THR A 371
VAL A 263
ILE A 308
None
1.18A 3sp9A-5v1bA:
undetectable
3sp9A-5v1bA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wjm CADHERIN-23

(Mus musculus)
no annotation 5 LEU A1891
PHE A1877
LEU A1922
VAL A1924
ILE A1867
None
MPD  A2009 (-3.7A)
None
None
None
0.96A 3sp9A-5wjmA:
undetectable
3sp9A-5wjmA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER


(Homo sapiens)
no annotation 5 CYH A  63
THR A 206
HIS A 178
VAL A 594
ILE A 223
None
1.23A 3sp9A-5zalA:
undetectable
3sp9A-5zalA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB)
no annotation 5 ILE A 152
LEU A  35
VAL A 122
ILE A 128
HIS A 131
None
1.25A 3sp9A-6etzA:
undetectable
3sp9A-6etzA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuz KINESIN LIGHT CHAIN
1,KINESIN LIGHT
CHAIN
1,C-JUN-AMINO-TERMIN
AL
KINASE-INTERACTING
PROTEIN 1
NANOBODY


(Homo sapiens;
Lama;
Mus musculus)
no annotation 5 PHE N  27
THR N  53
ILE N  51
LEU A 366
VAL A 380
None
0.90A 3sp9A-6fuzN:
undetectable
3sp9A-6fuzN:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpc -

(-)
no annotation 5 LEU A  46
ILE A  78
LEU A 123
VAL A 122
ILE A  73
None
1.28A 3sp9A-6gpcA:
undetectable
3sp9A-6gpcA:
undetectable