SIMILAR PATTERNS OF AMINO ACIDS FOR 3SP6_A_IL2A901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		5 SER A 124
TYR A  94
VAL A 324
HIS A 253
TYR A 192
 CO3  A 700 ( 4.6A)
FE  A 702 ( 4.3A)
None
FE  A 702 ( 3.4A)
CO3  A 700 ( 3.8A)
 1.48A 3sp6A-1h76A:
0.0		 3sp6A-1h76A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx6 XRP2 PROTEIN

(Homo sapiens) 		PF07986
(TBCC) 		5 PHE A 117
CYH A 130
CYH A 131
THR A 170
VAL A 119
 None
 1.50A 3sp6A-2bx6A:
undetectable		 3sp6A-2bx6A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr3 UPF0273 PROTEIN
PH0284

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		5 PHE A  39
THR A  34
VAL A 172
ILE A 192
VAL A  12
 None
ADP  A3801 (-4.2A)
None
None
None
 1.46A 3sp6A-2dr3A:
0.0		 3sp6A-2dr3A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6o MAJOR OUTER ENVELOPE
GLYCOPROTEIN GP350

(Human
gammaherpesvirus
4) 		PF05109
(Herpes_BLLF1) 		5 THR A 267
SER A 241
VAL A 181
ILE A 209
MET A 202
 None
 1.35A 3sp6A-2h6oA:
0.0		 3sp6A-2h6oA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1

(Gallus gallus) 		PF01267
(F-actin_cap_A) 		5 PHE A  96
TYR A 144
ILE A  76
MET A  59
VAL A  74
 None
 1.42A 3sp6A-2kxpA:
0.0		 3sp6A-2kxpA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 PHE A 273
CYH A 275
CYH A 276
THR A 279
SER A 280
TYR A 314
VAL A 332
ILE A 354
MET A 355
HIS A 440
VAL A 444
TYR A 464
 735  A 469 (-3.7A)
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-3.6A)
735  A 469 (-2.8A)
735  A 469 (-3.9A)
735  A 469 (-3.8A)
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 0.32A 3sp6A-2p54A:
41.7		 3sp6A-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 273
CYH A 275
CYH A 276
TYR A 464
ILE A 354
HIS A 440
 735  A 469 (-3.7A)
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-4.6A)
735  A 469 (-3.7A)
735  A 469 (-4.0A)
 1.47A 3sp6A-2p54A:
41.7		 3sp6A-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 TYR A 314
VAL A 324
MET A 355
HIS A 440
TYR A 464
 735  A 469 (-3.9A)
None
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 1.50A 3sp6A-2p54A:
41.7		 3sp6A-2p54A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6u UNCHARACTERIZED
PROTEIN

(Rhodococcus
jostii) 		PF00903
(Glyoxalase) 		5 PHE A   8
TYR A  38
VAL A 117
ILE A  10
VAL A  41
 None
 1.45A 3sp6A-2r6uA:
undetectable		 3sp6A-2r6uA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw NRFC PROTEIN

(Thermus
thermophilus) 		PF13247
(Fer4_11) 		5 CYH B 131
CYH B  19
THR B 134
ILE B  38
VAL B  14
 SF4  B1195 (-2.2A)
SF4  B1194 (-2.2A)
None
SF4  B1194 (-4.3A)
SF4  B1194 (-4.4A)
 1.40A 3sp6A-2vpwB:
0.0		 3sp6A-2vpwB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu6 YTH
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF04146
(YTH) 		5 PHE A  62
VAL A  91
ILE A  12
MET A  13
VAL A 117
 None
 1.46A 3sp6A-2yu6A:
undetectable		 3sp6A-2yu6A:
18.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 CYH A 285
SER A 289
MET A 364
HIS A 449
TYR A 473
 MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.9A)
 0.75A 3sp6A-3b0qA:
38.0		 3sp6A-3b0qA:
59.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
CYH A 285
THR A 288
ILE A 363
HIS A 449
TYR A 473
 L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.0A)
L41  A 501 ( 4.4A)
L41  A 501 (-3.9A)
L41  A 501 (-4.8A)
 0.90A 3sp6A-3d5fA:
37.1		 3sp6A-3d5fA:
70.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
CYH A 285
THR A 288
VAL A 341
HIS A 449
TYR A 473
 L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.0A)
L41  A 501 ( 4.4A)
L41  A 501 (-3.9A)
L41  A 501 (-4.8A)
 0.51A 3sp6A-3d5fA:
37.1		 3sp6A-3d5fA:
70.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		5 PHE C 455
THR C 461
SER C 462
MET C 408
VAL C  82
 None
 1.25A 3sp6A-3degC:
undetectable		 3sp6A-3degC:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 PHE D 282
SER D 289
MET D 364
HIS D 449
TYR D 473
 None
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.8A)
None
None
 0.70A 3sp6A-3dzuD:
35.5		 3sp6A-3dzuD:
43.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN

(Homo sapiens) 		PF02820
(MBT) 		5 CYH A 368
TYR A 357
VAL A 348
ILE A 375
VAL A 332
 None
 1.41A 3sp6A-3f70A:
undetectable		 3sp6A-3f70A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjl 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Bacillus
licheniformis) 		PF00171
(Aldedh) 		5 THR A 493
SER A 495
TYR A 502
ILE A 254
HIS A 506
 None
 1.23A 3sp6A-3rjlA:
undetectable		 3sp6A-3rjlA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		5 PHE A 168
SER A 160
TYR A 142
VAL A 203
MET A  93
 MN  A 402 ( 4.8A)
None
None
None
None
 1.48A 3sp6A-4dr0A:
2.8		 3sp6A-4dr0A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqt PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF06439
(DUF1080) 		5 VAL A 349
ILE A 397
HIS A 389
VAL A 387
TYR A 316
 None
 1.28A 3sp6A-4jqtA:
undetectable		 3sp6A-4jqtA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		5 THR D 144
VAL D  90
HIS D 457
VAL D 297
TYR D 231
 None
 1.34A 3sp6A-4ngeD:
undetectable		 3sp6A-4ngeD:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 PHE A  88
CYH A 236
ILE A 136
MET A 131
VAL A  78
 None
 1.43A 3sp6A-4ovqA:
undetectable		 3sp6A-4ovqA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmd ENDO-1,4-BETA-XYLANA
SE

(Caldicellulosiruptor
bescii) 		PF00331
(Glyco_hydro_10) 		5 PHE A  67
VAL A 130
ILE A  58
MET A  53
HIS A 119
 None
 1.22A 3sp6A-4pmdA:
undetectable		 3sp6A-4pmdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqi IN2-1 FAMILY
PROTEIN, GLUTATHIONE
TRANSFERASE LAMBDA3

(Populus
trichocarpa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 PHE A  43
CYH A  41
THR A  40
TYR A 235
TYR A 139
 GSH  A 301 (-3.8A)
GSH  A 301 (-2.0A)
None
None
None
 1.29A 3sp6A-4pqiA:
undetectable		 3sp6A-4pqiA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq7 PUTATIVE STRINGENT
STARVATION PROTEIN A

(Burkholderia
cenocepacia) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 PHE A  12
CYH A  10
VAL A  32
VAL A 105
TYR A 166
 GSH  A 301 (-3.7A)
GSH  A 301 (-3.4A)
None
None
None
 1.34A 3sp6A-4qq7A:
undetectable		 3sp6A-4qq7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rei MAJOR LATEX-LIKE
PROTEIN

(Panax ginseng) 		PF00407
(Bet_v_1) 		5 PHE A 101
THR A 131
SER A 132
ILE A  99
TYR A  60
 3MV  A 201 (-4.3A)
None
None
None
3MV  A 201 ( 3.6A)
 1.29A 3sp6A-4reiA:
undetectable		 3sp6A-4reiA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amw FRA A 2 ALLERGEN

(Fragaria x
ananassa) 		PF00407
(Bet_v_1) 		5 PHE A  59
TYR A 101
VAL A 148
HIS A  70
VAL A  68
 None
 1.28A 3sp6A-5amwA:
undetectable		 3sp6A-5amwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amw FRA A 2 ALLERGEN

(Fragaria x
ananassa) 		PF00407
(Bet_v_1) 		5 PHE A  59
TYR A 101
VAL A 148
ILE A  57
HIS A  70
 None
 1.22A 3sp6A-5amwA:
undetectable		 3sp6A-5amwA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4z CHEMOTAXIS PROTEIN

(Pseudomonas
syringae) 		PF17200
(sCache_2) 		5 THR A 106
ILE A 115
MET A 101
VAL A 126
TYR A 144
 None
None
None
None
UNL  A1179 ( 4.5A)
 1.49A 3sp6A-5g4zA:
undetectable		 3sp6A-5g4zA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijb TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Mus musculus) 		PF00560
(LRR_1)
PF11921
(DUF3439)
PF13855
(LRR_8) 		5 PHE A 441
THR A 493
ILE A 452
MET A 476
VAL A 435
 None
 1.46A 3sp6A-5ijbA:
undetectable		 3sp6A-5ijbA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j68 ASTROTACTIN-2

(Homo sapiens) 		PF01823
(MACPF) 		5 SER A1099
TYR A1101
ILE A1262
VAL A1047
TYR A1050
 None
 1.38A 3sp6A-5j68A:
undetectable		 3sp6A-5j68A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5la0 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		5 PHE A 276
CYH A 275
SER A 213
HIS A  90
VAL A 130
 None
 1.48A 3sp6A-5la0A:
undetectable		 3sp6A-5la0A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u38 LECTIN

(Platypodium
elegans) 		PF00139
(Lectin_legB) 		5 PHE A 234
THR A 176
VAL A 186
ILE A  93
VAL A  57
 None
 1.40A 3sp6A-5u38A:
undetectable		 3sp6A-5u38A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6u CYTOCHROME P450

(Rhodopseudomonas
palustris) 		no annotation 5 VAL A 359
ILE A 124
MET A 121
VAL A 159
TYR A 155
 HEM  A 501 (-4.7A)
None
None
None
None
 1.41A 3sp6A-5u6uA:
undetectable		 3sp6A-5u6uA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E

(Pyrococcus
furiosus) 		no annotation 5 THR A  45
SER A  44
ILE F  45
VAL F 134
TYR F  70
 None
 1.45A 3sp6A-6cfwA:
undetectable		 3sp6A-6cfwA:
18.07