SIMILAR PATTERNS OF AMINO ACIDS FOR 3SO9_A_017A100_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aip ELONGATION FACTOR TS

(Thermus
thermophilus) 		PF00889
(EF_TS) 		5 GLY C  15
ALA C  16
ASP C  20
GLY C 181
ILE C 180
 None
 0.97A 3so9A-1aipC:
0.0		 3so9A-1aipC:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akc ASPARTATE
AMINOTRANSFERASE

(Gallus gallus) 		PF00155
(Aminotran_1_2) 		4 GLY A 302
ALA A 303
GLY A 105
ILE A 106
 None
 0.51A 3so9A-1akcA:
undetectable		 3so9A-1akcA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ayy GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica) 		PF01112
(Asparaginase_2) 		4 ALA B 202
GLY B 188
ILE B 186
THR B 212
 None
 0.68A 3so9A-1ayyB:
0.0		 3so9A-1ayyB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4e PROTEIN
(5-AMINOLEVULINIC
ACID DEHYDRATASE)

(Escherichia
coli) 		PF00490
(ALAD) 		4 GLY A 158
ALA A 159
ASP A 160
ILE A 105
 None
 0.65A 3so9A-1b4eA:
undetectable		 3so9A-1b4eA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp2 NITROGENASE IRON
PROTEIN

(Clostridium
pasteurianum) 		PF00142
(Fer4_NifH) 		5 ALA A  41
ASP A  42
GLY A  13
ILE A  12
THR A  18
 None
 1.24A 3so9A-1cp2A:
0.0		 3so9A-1cp2A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7a PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Escherichia
coli) 		PF00731
(AIRC) 		5 GLY A  71
ALA A  70
ASP A  19
GLY A 122
ILE A 121
 AIR  A 300 (-3.6A)
AIR  A 300 (-3.5A)
AIR  A 300 (-2.6A)
None
None
 1.15A 3so9A-1d7aA:
undetectable		 3so9A-1d7aA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcq PYK2-ASSOCIATED
PROTEIN BETA

(Mus musculus) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 ASN A 261
GLY A 260
ASP A 271
GLY A 268
THR A 283
 None
 1.35A 3so9A-1dcqA:
undetectable		 3so9A-1dcqA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1deu PROCATHEPSIN X

(Homo sapiens) 		PF00112
(Peptidase_C1) 		5 GLY A  87
ALA A  83
ASP A  81
GLY A 130
ILE A 241
 None
 1.14A 3so9A-1deuA:
0.0		 3so9A-1deuA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		5 GLY M 195
ALA M 199
ASP M 211
GLY M 217
THR M 348
 None
 1.34A 3so9A-1dwaM:
undetectable		 3so9A-1dwaM:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 GLY A 106
ALA A 107
ASP A 108
ASP A 138
 None
 0.49A 3so9A-1e43A:
undetectable		 3so9A-1e43A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhf SEED COAT PEROXIDASE

(Glycine max) 		PF00141
(peroxidase) 		5 GLY A  51
ALA A  98
ASP A  99
GLY A 283
ILE A 285
 None
 1.41A 3so9A-1fhfA:
undetectable		 3so9A-1fhfA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 144
ALA A 143
ASP A 141
ASP A 140
GLY A 198
 None
None
ZN  A 501 ( 4.6A)
ZN  A 501 ( 2.5A)
None
 1.39A 3so9A-1fnoA:
undetectable		 3so9A-1fnoA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmm CBM6

(Ruminiclostridium
thermocellum) 		PF03422
(CBM_6) 		5 GLY A  62
ALA A  63
ASP A  64
GLY A 117
ILE A  35
 None
None
None
None
NA  A1131 (-4.1A)
 1.37A 3so9A-1gmmA:
undetectable		 3so9A-1gmmA:
19.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ALA A  28
ASP A  29
ASP A  30
GLY A  48
THR A  80
 A79  A 800 (-3.2A)
A79  A 800 (-2.7A)
A79  A 800 ( 4.7A)
A79  A 800 (-4.1A)
None
 0.87A 3so9A-1hvcA:
12.8		 3so9A-1hvcA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ALA A  28
ASP A  30
GLY A  49
ILE A  50
THR A  80
 A79  A 800 (-3.1A)
A79  A 800 ( 4.9A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.8A)
None
 0.84A 3so9A-1hvcA:
12.8		 3so9A-1hvcA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 GLY A  27
ALA A  28
ASP A  29
ASP A  30
GLY A  49
ILE A  50
 A79  A 800 (-3.0A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 ( 4.9A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.8A)
 0.67A 3so9A-1hvcA:
12.8		 3so9A-1hvcA:
42.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		7 GLY A  27
ALA A  28
ASP A  29
ASP A  30
GLY A  49
ILE A  50
THR A  80
 A79  A 800 (-3.0A)
A79  A 800 (-3.2A)
A79  A 800 (-2.7A)
A79  A 800 ( 4.7A)
A79  A 800 (-3.4A)
A79  A 800 ( 4.0A)
None
 0.84A 3so9A-1hvcA:
12.8		 3so9A-1hvcA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hy8 ACYL CARRIER PROTEIN

(Bacillus
subtilis) 		PF00550
(PP-binding) 		4 GLY A  33
ALA A  34
ASP A  38
GLY A  16
 None
 0.68A 3so9A-1hy8A:
undetectable		 3so9A-1hy8A:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig0 THIAMIN
PYROPHOSPHOKINASE

(Saccharomyces
cerevisiae) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		5 ASN A 307
GLY A 252
GLY A 249
ILE A 248
THR A 224
 None
 1.18A 3so9A-1ig0A:
undetectable		 3so9A-1ig0A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqg CARBOXYPEPTIDASE A

(Helicoverpa
armigera) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLY A 296
ALA A 229
ASP A 231
GLY A 223
ILE A 222
 None
 1.31A 3so9A-1jqgA:
undetectable		 3so9A-1jqgA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 216
ALA A 217
ASP A 218
ILE A 190
 None
 0.66A 3so9A-1jvbA:
undetectable		 3so9A-1jvbA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgs DNA BINDING RESPONSE
REGULATOR D

(Thermotoga
maritima) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		4 GLY A  96
ALA A  97
GLY A  61
THR A  81
 None
 0.62A 3so9A-1kgsA:
undetectable		 3so9A-1kgsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		4 GLY A  35
ALA A  34
GLY A  47
THR A 219
 None
 0.68A 3so9A-1kyhA:
undetectable		 3so9A-1kyhA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 GLY A 354
ALA A 349
ASP A 347
GLY A 509
THR A 313
 None
None
None
NA  A3002 ( 4.7A)
FAD  A3000 (-3.9A)
 1.42A 3so9A-1m64A:
undetectable		 3so9A-1m64A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md7 C1R COMPLEMENT
SERINE PROTEASE

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 GLY A 638
ALA A 637
ASP A 636
GLY A 468
ILE A 466
 None
 1.13A 3so9A-1md7A:
0.7		 3so9A-1md7A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mld MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASN A 118
ASP A  87
GLY A 178
ILE A 181
THR A 211
 CIT  A 375 (-3.2A)
None
None
None
None
 1.28A 3so9A-1mldA:
undetectable		 3so9A-1mldA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASN A 644
ALA A 637
ASP A 638
ASP A 639
GLY A 668
 None
 1.26A 3so9A-1n5xA:
undetectable		 3so9A-1n5xA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASN A 644
ALA A 637
ASP A 639
GLY A 668
ILE A 666
 None
 1.46A 3so9A-1n5xA:
undetectable		 3so9A-1n5xA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		4 GLY A 193
ALA A 194
ASP A 195
THR A 146
 None
 0.54A 3so9A-1n8pA:
undetectable		 3so9A-1n8pA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzy 4-CHLOROBENZOYL
COENZYME A
DEHALOGENASE

(Pseudomonas sp.
CBS3) 		PF00378
(ECH_1) 		5 ASN B  25
GLY B  55
ALA B  56
GLY B   6
ILE B  16
 None
None
None
EDO  B 901 ( 4.2A)
None
 1.33A 3so9A-1nzyB:
undetectable		 3so9A-1nzyB:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc3 PHOSPHATE-BINDING
PROTEIN 1

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		5 GLY A  66
ALA A  67
GLY A  80
ILE A 295
THR A  76
 None
 0.91A 3so9A-1pc3A:
undetectable		 3so9A-1pc3A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		5 GLY A 349
ASP A 352
GLY A 194
ILE A 193
THR A 331
 None
MG  A 395 ( 3.0A)
None
None
None
 1.48A 3so9A-1phpA:
undetectable		 3so9A-1phpA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q56 AGRIN

(Gallus gallus) 		PF00054
(Laminin_G_1) 		5 GLY A 165
ASP A  20
GLY A 144
ILE A  56
THR A 161
 None
 1.02A 3so9A-1q56A:
undetectable		 3so9A-1q56A:
19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q9p HIV-1 PROTEASE

(Homo sapiens) 		PF00077
(RVP) 		4 GLY A  27
ALA A  28
ASP A  29
ASP A  30
 None
 0.52A 3so9A-1q9pA:
9.9		 3so9A-1q9pA:
84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		7 GLY A  27
ALA A  28
ASP A  29
ASP A  30
GLY A  49
ILE A  50
THR A  80
 None
 0.84A 3so9A-1sivA:
17.9		 3so9A-1sivA:
47.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		5 GLY A  27
ALA A  28
ASP A  29
GLY A  48
THR A  80
 None
 0.97A 3so9A-1sivA:
17.9		 3so9A-1sivA:
47.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		4 GLY A 456
ALA A 457
ASP A 472
GLY A 526
 None
 0.69A 3so9A-1sqjA:
undetectable		 3so9A-1sqjA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		5 ASN A 244
GLY A 232
ALA A 233
GLY A  49
THR A  90
 None
None
None
SO4  A 401 (-3.3A)
None
 1.31A 3so9A-1t9kA:
undetectable		 3so9A-1t9kA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE

(Bacillus
subtilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 164
ASP A 166
ASP A 167
ILE A 175
 None
 0.68A 3so9A-1tkkA:
undetectable		 3so9A-1tkkA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlg POLYANDROCARPA
LECTIN

(Polyandrocarpa
misakiensis) 		PF00059
(Lectin_C) 		4 GLY A  56
ALA A  57
ASP A  58
GLY A  72
 None
 0.49A 3so9A-1tlgA:
undetectable		 3so9A-1tlgA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u11 PURE
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
MUTASE)

(Acetobacter
aceti) 		PF00731
(AIRC) 		5 GLY A  85
ALA A  84
ASP A  33
GLY A 136
ILE A 135
 CIT  A1001 (-4.3A)
CIT  A1001 (-3.8A)
CIT  A1001 (-2.9A)
None
None
 1.16A 3so9A-1u11A:
undetectable		 3so9A-1u11A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9n MALATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF02615
(Ldh_2) 		5 GLY A 145
ALA A 173
GLY A 142
ILE A 287
THR A 176
 None
 1.44A 3so9A-1v9nA:
undetectable		 3so9A-1v9nA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG

(Clostridium
acetobutylicum) 		PF04321
(RmlD_sub_bind) 		5 ASN A  57
ALA A  59
GLY A  13
ILE A  16
THR A  30
 None
NAI  A 300 (-3.2A)
None
None
None
 1.40A 3so9A-1vl0A:
undetectable		 3so9A-1vl0A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		5 ASN B 290
GLY B 278
ALA B 279
GLY A  52
THR A 108
 None
None
None
SO4  A1212 (-3.6A)
None
 1.36A 3so9A-1w2wB:
undetectable		 3so9A-1w2wB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		4 GLY A 424
ALA A 425
ASP A 426
ILE A 354
 None
 0.63A 3so9A-1x0uA:
undetectable		 3so9A-1x0uA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7f OUTER SURFACE
PROTEIN

(Bacillus cereus) 		PF05913
(DUF871) 		4 GLY A  92
ALA A  93
ASP A  94
ILE A  55
 None
 0.63A 3so9A-1x7fA:
undetectable		 3so9A-1x7fA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A 115
ASP A  37
GLY A  10
ILE A   7
THR A 102
 None
FAD  A 999 (-3.5A)
FAD  A 999 (-4.8A)
None
None
 1.38A 3so9A-1xdiA:
undetectable		 3so9A-1xdiA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE

(Bacillus
anthracis) 		PF00731
(AIRC) 		5 GLY A  66
ALA A  65
ASP A  14
GLY A 117
ILE A 116
 None
 1.14A 3so9A-1xmpA:
undetectable		 3so9A-1xmpA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II

(Sporidiobolus
salmonicolor) 		PF01370
(Epimerase) 		5 GLY A  76
ALA A  77
ASP A  71
GLY A 111
THR A  18
 None
 1.40A 3so9A-1y1pA:
undetectable		 3so9A-1y1pA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		5 ALA B 151
ASP B 147
GLY B  40
ILE B  39
THR B  19
 None
FMN  A 802 ( 4.8A)
None
None
None
 1.28A 3so9A-1y56B:
undetectable		 3so9A-1y56B:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb1 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE
TYPE XI

(Homo sapiens) 		PF00106
(adh_short) 		4 GLY A 117
ALA A 116
GLY A  44
ILE A  43
 None
CL  A 402 ( 4.1A)
None
SO4  A 702 (-3.8A)
 0.69A 3so9A-1yb1A:
undetectable		 3so9A-1yb1A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb4 TARTRONIC
SEMIALDEHYDE
REDUCTASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 GLY A 111
ALA A 112
ASP A 113
THR A  53
 None
 0.57A 3so9A-1yb4A:
undetectable		 3so9A-1yb4A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 GLY A 180
ALA A 179
GLY A 242
ILE A 243
 None
 0.67A 3so9A-1yw6A:
undetectable		 3so9A-1yw6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a18 CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK HOMOLOG 4

(Synechocystis
sp. PCC 6803) 		PF00936
(BMC) 		4 GLY A  40
ALA A  39
ILE A  13
THR A  76
 None
 0.68A 3so9A-2a18A:
undetectable		 3so9A-2a18A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLY A 173
ALA A 174
ASP A 179
GLY A 184
ILE A 169
 None
 1.25A 3so9A-2akzA:
undetectable		 3so9A-2akzA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Mytilus edulis) 		PF00150
(Cellulase) 		4 GLY A 128
ALA A 129
GLY A 204
ILE A 182
 None
 0.71A 3so9A-2c0hA:
undetectable		 3so9A-2c0hA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE

(Anopheles
gambiae) 		PF00266
(Aminotran_5) 		4 GLY A  81
ALA A  80
GLY A 212
ILE A 213
 None
 0.68A 3so9A-2ch1A:
undetectable		 3so9A-2ch1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxh PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN

(Aeropyrum
pernix) 		no annotation 4 GLY A  63
ALA A  64
ASP A  65
GLY A  41
 None
 0.69A 3so9A-2cxhA:
undetectable		 3so9A-2cxhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT
DIOL
DEHYDRATASE-REACTIVA
TING FACTOR SMALL
SUBUNIT

(Klebsiella
oxytoca) 		PF02288
(Dehydratase_MU)
PF08841
(DDR) 		5 ASN A 173
ASP A 167
GLY B  28
ILE B  29
THR A 105
 None
None
None
None
MG  A1005 (-3.1A)
 1.41A 3so9A-2d0oA:
undetectable		 3so9A-2d0oA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 GLY A 304
GLY A 126
ILE A 127
THR A 325
 None
 0.62A 3so9A-2e3jA:
undetectable		 3so9A-2e3jA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 216
ALA A 217
ASP A 218
ILE A 190
 None
 0.70A 3so9A-2eerA:
undetectable		 3so9A-2eerA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		4 GLY A 168
ALA A 167
GLY A 159
ILE A 158
 None
 0.70A 3so9A-2fi1A:
undetectable		 3so9A-2fi1A:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		4 GLY A  27
ALA A  28
ASP A  29
GLY A  55
 LP1  A 201 (-3.8A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
LP1  A 201 (-3.4A)
 0.37A 3so9A-2fmbA:
14.6		 3so9A-2fmbA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9i F420-0:GAMMA-GLUTAMY
L LIGASE

(Archaeoglobus
fulgidus) 		PF01996
(F420_ligase) 		5 GLY A 162
ALA A 199
ASP A 196
GLY A 166
ILE A 148
 None
 1.40A 3so9A-2g9iA:
undetectable		 3so9A-2g9iA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn1 THREONINE
DEHYDRATASE
CATABOLIC

(Salmonella
enterica) 		PF00291
(PALP) 		5 GLY A 285
ALA A 284
ASP A 236
GLY A 184
ILE A 183
 LLP  A  58 ( 4.8A)
LLP  A  58 ( 3.4A)
None
LLP  A  58 ( 3.5A)
None
 1.31A 3so9A-2gn1A:
undetectable		 3so9A-2gn1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF00480
(ROK) 		5 GLY A 129
ALA A 101
ASP A 100
GLY A 124
ILE A 123
 None
None
TRS  A 293 (-2.8A)
None
None
 1.17A 3so9A-2gupA:
undetectable		 3so9A-2gupA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		4 GLY A 388
ALA A 389
ASP A 390
ILE A 270
 None
 0.64A 3so9A-2gwcA:
undetectable		 3so9A-2gwcA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 ALA A 261
ASP A 262
ASP A 263
GLY A 255
ILE A 254
 None
 1.15A 3so9A-2h8oA:
undetectable		 3so9A-2h8oA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcz BETA-EXPANSIN 1A

(Zea mays) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		4 GLY X 195
ALA X 196
GLY X  71
ILE X  93
 None
 0.69A 3so9A-2hczX:
undetectable		 3so9A-2hczX:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE

(Thermotoga
maritima) 		PF00480
(ROK) 		4 ASN A 184
ASP A 157
GLY A 211
ILE A 212
 GOL  A 370 ( 3.1A)
None
None
None
 0.69A 3so9A-2hoeA:
undetectable		 3so9A-2hoeA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		5 GLY A  26
ALA A  25
ASP A  28
ILE A 511
THR A  50
 None
 1.17A 3so9A-2i3oA:
undetectable		 3so9A-2i3oA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilu ALDEHYDE
DEHYDROGENASE A

(Escherichia
coli) 		PF00171
(Aldedh) 		5 ASN A 203
GLY A 200
ALA A  53
GLY A 144
THR A 147
 None
 1.30A 3so9A-2iluA:
undetectable		 3so9A-2iluA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iod DIHYDROFLAVONOL
4-REDUCTASE

(Vitis vinifera) 		PF01370
(Epimerase) 		5 GLY A  69
ASP A  67
ASP A  64
GLY A 106
THR A  11
 None
None
NAP  A1340 (-3.6A)
None
None
 1.45A 3so9A-2iodA:
undetectable		 3so9A-2iodA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		4 ASN A 532
GLY A 500
ALA A 499
GLY A 473
 None
 0.58A 3so9A-2j6hA:
undetectable		 3so9A-2j6hA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0r THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Neisseria
meningitidis) 		PF11412
(DsbC) 		5 GLY A  25
ALA A  22
ASP A  23
GLY A 120
ILE A 118
 None
 1.21A 3so9A-2k0rA:
undetectable		 3so9A-2k0rA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mk5 ENDOLYSIN

(Staphylococcus
virus G15) 		PF08460
(SH3_5) 		5 ASN A 105
GLY A 104
ALA A 101
GLY A  98
THR A  62
 None
 1.46A 3so9A-2mk5A:
undetectable		 3so9A-2mk5A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2noq 60S RIBOSOMAL
PROTEIN L11-B

(Saccharomyces
cerevisiae) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		4 GLY H 134
ALA H 135
GLY H 148
THR H 153
 None
 0.71A 3so9A-2noqH:
undetectable		 3so9A-2noqH:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxo HYPOTHETICAL PROTEIN
SCO4506

(Streptomyces
coelicolor) 		PF02621
(VitK2_biosynth) 		4 GLY A  50
GLY A  55
ILE A  54
THR A  36
 None
 0.67A 3so9A-2nxoA:
undetectable		 3so9A-2nxoA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ASN A  40
GLY A  18
ALA A  37
ASP A  36
GLY A 619
 None
 1.46A 3so9A-2nyaA:
undetectable		 3so9A-2nyaA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oej 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Geobacillus
kaustophilus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 232
ALA A 233
ASP A 234
GLY A 193
 None
 0.70A 3so9A-2oejA:
undetectable		 3so9A-2oejA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 ALA A 158
ASP A 157
GLY A 140
ILE A 168
THR A 143
 None
None
UD1  A4000 (-3.3A)
None
None
 1.20A 3so9A-2oi6A:
undetectable		 3so9A-2oi6A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn2 UNCHARACTERIZED
PROTEIN

(Psychrobacter
arcticus) 		PF02566
(OsmC) 		5 ASN A  97
GLY A  71
ALA A  70
GLY A  59
ILE A  58
 None
 1.09A 3so9A-2pn2A:
undetectable		 3so9A-2pn2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A  67
ALA A  68
ASP A  71
GLY A 110
ILE A  16
 GSP  A 401 (-3.3A)
GSP  A 401 (-3.5A)
None
None
None
 1.32A 3so9A-2q1yA:
undetectable		 3so9A-2q1yA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE

(Arabidopsis
thaliana) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ASN A  19
GLY A  44
ALA A  45
ASP A 307
ILE A  50
 None
None
None
None
SUC  A 800 ( 4.6A)
 1.38A 3so9A-2qquA:
undetectable		 3so9A-2qquA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtk PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		5 GLY A  96
ALA A  60
ASP A  59
ILE A  42
THR A  11
 None
 1.31A 3so9A-2qtkA:
undetectable		 3so9A-2qtkA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qu7 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Staphylococcus
saprophyticus) 		PF13407
(Peripla_BP_4) 		5 GLY A 277
ALA A 249
GLY A 246
ILE A 274
THR A 236
 None
 1.40A 3so9A-2qu7A:
undetectable		 3so9A-2qu7A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		5 ASN A 696
GLY A 820
GLY A 743
ILE A 744
THR A 692
 None
None
ZN  A1006 ( 4.4A)
None
None
 1.49A 3so9A-2r6fA:
undetectable		 3so9A-2r6fA:
7.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ALA A  28
ASP A  29
ASP A  30
GLY A  48
THR A  80
 AB1  A 501 (-3.5A)
AB1  A 501 ( 3.3A)
AB1  A 501 (-3.8A)
AB1  A 501 (-4.2A)
None
 0.89A 3so9A-2rkfA:
19.6		 3so9A-2rkfA:
80.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		7 GLY A  27
ALA A  28
ASP A  29
ASP A  30
GLY A  49
ILE A  50
THR A  80
 AB1  A 501 (-3.9A)
AB1  A 501 (-3.5A)
AB1  A 501 ( 3.3A)
AB1  A 501 (-3.8A)
AB1  A 501 (-3.5A)
AB1  A 501 (-3.8A)
None
 0.73A 3so9A-2rkfA:
19.6		 3so9A-2rkfA:
80.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvd 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		4 GLY A  91
ALA A  90
GLY A  17
ILE A  16
 None
 0.70A 3so9A-2uvdA:
undetectable		 3so9A-2uvdA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 GLY A 248
ALA A 249
ASP A 250
ASP A 251
 None
 0.68A 3so9A-2vn8A:
undetectable		 3so9A-2vn8A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq2 PUTATIVE FIMBRIAL
BIOGENESIS AND
TWITCHING MOTILITY
PROTEIN

(Neisseria
meningitidis) 		PF13429
(TPR_15) 		4 ASN A 108
ALA A 143
GLY A 148
ILE A 149
 None
 0.71A 3so9A-2vq2A:
undetectable		 3so9A-2vq2A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B

(Mycobacterium
tuberculosis) 		PF02502
(LacAB_rpiB) 		5 GLY A   9
ALA A  10
ASP A  11
GLY A 109
ILE A 108
 None
None
R10  A 200 (-2.8A)
None
None
 1.37A 3so9A-2vvqA:
undetectable		 3so9A-2vvqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		4 GLY A 468
ALA A 467
GLY A 309
THR A 339
 None
 0.67A 3so9A-2w8qA:
undetectable		 3so9A-2w8qA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL

(Homo sapiens) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLY A 280
ALA A 281
ASP A 255
GLY A 247
 None
 0.60A 3so9A-2wd9A:
undetectable		 3so9A-2wd9A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 163
ALA A 162
ASP A 106
GLY A 159
 None
 0.70A 3so9A-2wgeA:
undetectable		 3so9A-2wgeA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whd THIOREDOXIN
REDUCTASE

(Hordeum vulgare) 		PF07992
(Pyr_redox_2) 		4 GLY A 230
ALA A 229
GLY A 141
ILE A 142
 None
 0.63A 3so9A-2whdA:
undetectable		 3so9A-2whdA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		4 GLY A 187
ALA A 186
ASP A 277
GLY A 183
 None
 0.63A 3so9A-2xu0A:
undetectable		 3so9A-2xu0A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		5 ASN A 240
GLY A 182
ALA A 246
ASP A 249
ILE A 177
 None
 1.28A 3so9A-2xuzA:
undetectable		 3so9A-2xuzA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 GLY X 255
ALA X 256
GLY X 451
ILE X 450
 None
 0.63A 3so9A-2y9eX:
undetectable		 3so9A-2y9eX:
9.01