SIMILAR PATTERNS OF AMINO ACIDS FOR 3SNF_A_ACTA110

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfb DROSOPHILA
NEUROGLIAN

(Drosophila
melanogaster) 		PF00041
(fn3) 		4 ILE A 740
THR A 653
THR A 656
PHE A 651
 NA  A   5 ( 4.8A)
None
None
None
 1.21A 3snfA-1cfbA:
undetectable		 3snfA-1cfbA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE
PENICILLIN G AMIDASE

(Providencia
rettgeri;
Providencia
rettgeri) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		4 ILE A 188
THR A 187
THR A 186
SER B 243
 None
 1.01A 3snfA-1cp9A:
0.0		 3snfA-1cp9A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 147
THR A 145
SER A 144
PHE A 130
 None
 1.20A 3snfA-1d1tA:
0.0		 3snfA-1d1tA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dih DIHYDRODIPICOLINATE
REDUCTASE

(Escherichia
coli) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		4 ILE A 101
THR A 103
THR A  80
PHE A 106
 None
NDP  A 301 (-4.1A)
NDP  A 301 ( 3.7A)
None
 1.22A 3snfA-1dihA:
undetectable		 3snfA-1dihA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT

(Shigella
dysenteriae) 		PF00161
(RIP) 		4 ILE A  57
THR A 137
SER A 138
PHE A 161
 None
 1.11A 3snfA-1dm0A:
0.0		 3snfA-1dm0A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		4 ILE A  44
THR A 265
THR A 266
PHE A  40
 None
 1.05A 3snfA-1dy6A:
0.0		 3snfA-1dy6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eun KDPG ALDOLASE

(Escherichia
coli) 		PF01081
(Aldolase) 		4 ILE A 149
THR A 117
SER A 116
PHE A 134
 None
 1.19A 3snfA-1eunA:
0.0		 3snfA-1eunA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3y DIADENOSINE
5',5'''-P1,P4-TETRAP
HOSPHATE HYDROLASE

(Lupinus
angustifolius) 		PF00293
(NUDIX) 		4 ILE A 119
THR A  68
SER A  69
PHE A 112
 None
 0.96A 3snfA-1f3yA:
0.0		 3snfA-1f3yA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ILE A 115
THR A  23
THR A  24
SER A  21
 None
None
None
5GP  A 507 (-3.5A)
 1.13A 3snfA-1g7cA:
undetectable		 3snfA-1g7cA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ght TRANSPOSON
GAMMA-DELTA
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase) 		4 ILE A  80
THR A  99
SER A  98
PHE A  92
 None
 1.11A 3snfA-1ghtA:
undetectable		 3snfA-1ghtA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nc7 HYPOTHETICAL PROTEIN
TM1070

(Thermotoga
maritima) 		PF07100
(ASRT) 		4 ILE A 109
THR A 108
THR A 107
PHE A   9
 None
 0.88A 3snfA-1nc7A:
undetectable		 3snfA-1nc7A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrk YGFZ PROTEIN

(Escherichia
coli) 		PF01571
(GCV_T) 		4 ILE A 163
THR A 149
THR A 150
PHE A 133
 None
 1.13A 3snfA-1nrkA:
undetectable		 3snfA-1nrkA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE

(Pseudomonas sp.
P51) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  33
THR A   9
THR A   8
SER A   7
 None
 1.12A 3snfA-1nu5A:
undetectable		 3snfA-1nu5A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A1147
THR A1145
SER A1144
PHE A1130
 None
 1.21A 3snfA-1p0cA:
undetectable		 3snfA-1p0cA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ILE A  39
THR A 122
THR A 119
SER A 118
 None
None
None
FAD  A 304 (-2.5A)
 0.99A 3snfA-1qgzA:
undetectable		 3snfA-1qgzA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmo MANNOSE BINDING
LECTIN, FRIL

(Lablab
purpureus) 		PF00139
(Lectin_legB) 		4 ILE E 182
THR E 194
SER E 195
PHE E 139
 None
 1.09A 3snfA-1qmoE:
undetectable		 3snfA-1qmoE:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suj CONE ARRESTIN

(Ambystoma
tigrinum) 		PF00339
(Arrestin_N)
PF02752
(Arrestin_C) 		4 ILE A 303
THR A 301
THR A 300
SER A 317
 None
 1.09A 3snfA-1sujA:
undetectable		 3snfA-1sujA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		4 ILE A 215
THR A 204
SER A 231
PHE A 229
 None
 1.07A 3snfA-1ur4A:
undetectable		 3snfA-1ur4A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uus STAT PROTEIN

(Dictyostelium
discoideum) 		PF00017
(SH2)
PF09267
(Dict-STAT-coil) 		4 ILE A 579
THR A 572
SER A 569
PHE A 613
 None
 1.19A 3snfA-1uusA:
undetectable		 3snfA-1uusA:
14.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yv7 P-30 PROTEIN

(Rana pipiens) 		PF00074
(RnaseA) 		4 ILE A  47
THR A  59
THR A  60
PHE A  86
 None
 1.16A 3snfA-1yv7A:
21.5		 3snfA-1yv7A:
99.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yv7 P-30 PROTEIN

(Rana pipiens) 		PF00074
(RnaseA) 		5 ILE A  47
THR A  59
THR A  60
SER A  61
PHE A  63
 None
 0.37A 3snfA-1yv7A:
21.5		 3snfA-1yv7A:
99.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE

(Homo sapiens) 		PF13561
(adh_short_C2) 		4 ILE A  75
THR A  97
THR A  94
SER A  93
 None
 0.93A 3snfA-1yxmA:
undetectable		 3snfA-1yxmA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahr PUTATIVE PYRROLINE
CARBOXYLATE
REDUCTASE

(Streptococcus
pyogenes) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 ILE A 108
THR A 121
THR A 147
PHE A 144
 None
 1.09A 3snfA-2ahrA:
undetectable		 3snfA-2ahrA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 ILE A  36
THR A  32
SER A  29
PHE A  61
 None
 1.14A 3snfA-2e3xA:
undetectable		 3snfA-2e3xA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		4 ILE A 586
THR A 597
THR A 595
PHE A 175
 None
None
FAD  A1625 (-3.4A)
None
 1.03A 3snfA-2f5vA:
undetectable		 3snfA-2f5vA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		4 ILE A 508
THR A 139
THR A 136
PHE A 408
 None
 1.17A 3snfA-2fgyA:
undetectable		 3snfA-2fgyA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hke DIPHOSPHOMEVALONATE
DECARBOXYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00288
(GHMP_kinases_N) 		4 ILE A 262
THR A 258
THR A 257
SER A 210
 None
 1.16A 3snfA-2hkeA:
undetectable		 3snfA-2hkeA:
14.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lt5 PROTEIN P-30

(Rana pipiens) 		PF00074
(RnaseA) 		4 ILE A  95
THR A 107
THR A 108
PHE A  14
 None
 1.16A 3snfA-2lt5A:
5.0		 3snfA-2lt5A:
70.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lt5 PROTEIN P-30

(Rana pipiens) 		PF00074
(RnaseA) 		4 ILE A  95
THR A 107
THR A 108
SER A 109
 None
 0.72A 3snfA-2lt5A:
5.0		 3snfA-2lt5A:
70.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2lt5 PROTEIN P-30

(Rana pipiens) 		PF00074
(RnaseA) 		4 THR A 107
THR A 108
SER A 109
PHE A 111
 None
 0.97A 3snfA-2lt5A:
5.0		 3snfA-2lt5A:
70.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m9v TELOMERE REPLICATION
PROTEIN EST3

(Saccharomyces
cerevisiae) 		PF10341
(TPP1) 		4 ILE A 162
THR A 115
THR A 112
SER A 113
 None
 1.22A 3snfA-2m9vA:
undetectable		 3snfA-2m9vA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2muy ATP-DEPENDENT ZINC
METALLOPROTEASE FTSH

(Escherichia
coli) 		PF06480
(FtsH_ext) 		4 ILE A  56
THR A  68
THR A  67
PHE A  37
 None
 1.07A 3snfA-2muyA:
undetectable		 3snfA-2muyA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		4 ILE A 282
THR A 283
THR A 290
SER A 291
 None
 1.21A 3snfA-2nwhA:
undetectable		 3snfA-2nwhA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA

(-) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A  87
THR A 103
SER A 100
PHE A  99
 None
 1.03A 3snfA-2qgyA:
undetectable		 3snfA-2qgyA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 ILE A 173
THR A 143
THR A 144
PHE A 200
 None
 1.21A 3snfA-2vsaA:
undetectable		 3snfA-2vsaA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk1 NOVP

(Actinoalloteichus
cyanogriseus) 		PF05711
(TylF) 		4 THR A 206
THR A 203
SER A 202
PHE A 178
 None
EDO  A 551 (-3.2A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.4A)
 1.05A 3snfA-2wk1A:
undetectable		 3snfA-2wk1A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3n PROBABLE
FAD-DEPENDENT
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 ILE A 300
THR A 356
SER A 357
PHE A 364
 None
 1.22A 3snfA-2x3nA:
undetectable		 3snfA-2x3nA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		4 ILE A  62
THR A  57
THR A  56
PHE A 268
 None
 1.19A 3snfA-3biwA:
undetectable		 3snfA-3biwA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 ILE A 866
THR A 869
THR A 870
SER A 871
 None
 1.10A 3snfA-3cmmA:
undetectable		 3snfA-3cmmA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5l PUTATIVE
S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF13649
(Methyltransf_25) 		4 ILE A  58
THR A  85
THR A  86
SER A  87
 None
 0.90A 3snfA-3g5lA:
undetectable		 3snfA-3g5lA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		4 ILE A 200
THR A 269
THR A 270
PHE A 289
 None
 0.78A 3snfA-3gs9A:
undetectable		 3snfA-3gs9A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip3 OXIDOREDUCTASE,
PUTATIVE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A 182
THR A 309
SER A 306
PHE A 126
 None
 1.18A 3snfA-3ip3A:
undetectable		 3snfA-3ip3A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 ILE C 278
THR C 315
THR C 316
PHE C 297
 None
 0.98A 3snfA-3j9uC:
undetectable		 3snfA-3j9uC:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks5 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		4 ILE A 122
THR A 151
THR A 152
PHE A 136
 None
 1.04A 3snfA-3ks5A:
undetectable		 3snfA-3ks5A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		4 ILE A 185
THR A 245
THR A 246
SER A 247
 None
None
None
F1X  A   1 (-3.3A)
 0.95A 3snfA-3o75A:
undetectable		 3snfA-3o75A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phu RNA-DIRECTED RNA
POLYMERASE L

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02338
(OTU) 		4 ILE A 118
THR A 102
SER A 101
PHE A 152
 None
 1.03A 3snfA-3phuA:
undetectable		 3snfA-3phuA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg URACIL-DNA
GLYCOSYLASE

(Staphylococcus
aureus) 		PF03167
(UDG) 		4 ILE A  10
THR A  11
THR A  12
PHE A  16
 None
 1.11A 3snfA-3wdgA:
undetectable		 3snfA-3wdgA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq6 PUTATIVE ARSENICAL
PUMP-DRIVING ATPASE

(Methanothermobacter
thermautotrophicus) 		PF02374
(ArsA_ATPase) 		4 ILE A 141
THR A  15
THR A  14
PHE A   9
 None
 1.15A 3snfA-3zq6A:
undetectable		 3snfA-3zq6A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ala FAB 2H12 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ILE H  72
THR H  74
SER H  76
PHE H  29
 None
 1.16A 3snfA-4alaH:
undetectable		 3snfA-4alaH:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 ILE A  57
THR A  52
THR A  51
PHE A 117
 None
 1.22A 3snfA-4b9yA:
undetectable		 3snfA-4b9yA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buc UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Thermotoga
maritima) 		PF08245
(Mur_ligase_M) 		4 THR A 137
THR A 135
SER A 134
PHE A 157
 None
PO4  A1001 ( 3.1A)
GOL  A1202 (-4.2A)
None
 1.16A 3snfA-4bucA:
undetectable		 3snfA-4bucA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		4 ILE A 809
THR A 560
THR A 568
PHE A 558
 None
 1.08A 3snfA-4ci8A:
undetectable		 3snfA-4ci8A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csi CELLULASE

(Humicola grisea) 		PF00840
(Glyco_hydro_7) 		4 ILE A 287
THR A 283
THR A 284
SER A 135
 None
 1.15A 3snfA-4csiA:
undetectable		 3snfA-4csiA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 PROTEIN CAF40

(Saccharomyces
cerevisiae) 		PF04078
(Rcd1) 		4 THR B 211
THR B 212
SER B 213
PHE B 218
 None
 1.06A 3snfA-4cv5B:
undetectable		 3snfA-4cv5B:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d72 GLYCOSIDE HYDROLASE

(Streptococcus
pneumoniae) 		PF08306
(Glyco_hydro_98M)
PF08307
(Glyco_hydro_98C) 		4 ILE A 596
THR A 636
THR A 635
SER A 638
 None
 1.15A 3snfA-4d72A:
undetectable		 3snfA-4d72A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dbh 2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Corynebacterium
glutamicum) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 ILE A 106
THR A 111
SER A 150
PHE A 169
 None
 1.21A 3snfA-4dbhA:
undetectable		 3snfA-4dbhA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgw GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(+)] 1

(Saccharomyces
cerevisiae) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 ILE A 238
THR A 197
THR A 196
SER A 296
 None
 1.14A 3snfA-4fgwA:
undetectable		 3snfA-4fgwA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8z DIHYDROFOLATE
REDUCTASE

(Pneumocystis
jirovecii) 		PF00186
(DHFR_1) 		4 ILE X 150
THR X  14
THR X  15
SER X  16
 None
 0.99A 3snfA-4g8zX:
undetectable		 3snfA-4g8zX:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he4 YELLOW FLUORESCENT
PROTEIN

(Phialidium sp.
SL-2003) 		PF01353
(GFP) 		4 ILE A 165
THR A  59
SER A  58
PHE A 143
 None
None
None
CRO  A  65 ( 4.7A)
 0.97A 3snfA-4he4A:
undetectable		 3snfA-4he4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 ILE B  37
THR B  19
THR B  18
PHE B  82
 None
 0.91A 3snfA-4i6mB:
undetectable		 3snfA-4i6mB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irn PROLYL-ACP
DEHYDROGENASE

([Oscillatoria]
sp. PCC 6506) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 236
THR A 185
THR A 184
PHE A 171
 None
 1.21A 3snfA-4irnA:
undetectable		 3snfA-4irnA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		4 THR A 252
THR A 253
SER A 254
PHE A 247
 None
 1.03A 3snfA-4k6nA:
undetectable		 3snfA-4k6nA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktz RUVC ENDONUCLEASE

(Lactococcus
virus bIL67) 		PF07066
(DUF3882) 		4 ILE A  50
THR A  19
SER A  10
PHE A   9
 None
 1.12A 3snfA-4ktzA:
undetectable		 3snfA-4ktzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		4 ILE A 397
THR A 345
THR A 346
PHE A 369
 None
 0.95A 3snfA-4m46A:
undetectable		 3snfA-4m46A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		4 ILE A 589
THR A 600
THR A 598
PHE A 166
 None
None
FDA  A 801 (-3.4A)
None
 1.09A 3snfA-4mifA:
undetectable		 3snfA-4mifA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q05 ESTERASE E25

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ILE A 277
THR A 214
SER A 185
PHE A 211
 None
 0.98A 3snfA-4q05A:
undetectable		 3snfA-4q05A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qey UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14466
(PLCC) 		4 ILE A 124
THR A  32
THR A  33
SER A  97
 None
 1.23A 3snfA-4qeyA:
undetectable		 3snfA-4qeyA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 229
THR A 224
THR A 221
PHE A  77
 None
None
3UK  A 601 (-3.8A)
None
 1.17A 3snfA-4wv3A:
undetectable		 3snfA-4wv3A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A2647
THR A2711
THR A2657
PHE A2713
 None
 1.11A 3snfA-4z37A:
undetectable		 3snfA-4z37A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT K

(Oryctolagus
cuniculus) 		PF10075
(CSN8_PSD8_EIF3K) 		4 ILE K  99
THR K  66
THR K  64
PHE K  61
 None
 1.09A 3snfA-5a5tK:
undetectable		 3snfA-5a5tK:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		4 ILE A 159
THR A 162
THR A 161
PHE A 126
 None
 1.23A 3snfA-5b1qA:
undetectable		 3snfA-5b1qA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv5 CYTOCHROME P450 119

(Sulfolobus
solfataricus) 		PF00067
(p450) 		4 ILE A 128
THR A 102
THR A 103
PHE A  98
 None
 1.21A 3snfA-5bv5A:
undetectable		 3snfA-5bv5A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2c FORM II RUBISCO

(Gallionella) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ILE A 366
THR A 364
THR A 363
SER A 318
 None
 1.15A 3snfA-5c2cA:
undetectable		 3snfA-5c2cA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chl HISTONE H2A.Z

(Homo sapiens) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		4 ILE B  58
THR B 114
THR B 115
SER B 116
 None
 1.11A 3snfA-5chlB:
undetectable		 3snfA-5chlB:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		4 ILE A 318
THR A 344
THR A 346
PHE A 364
 None
 1.22A 3snfA-5ddbA:
undetectable		 3snfA-5ddbA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 ILE A 221
THR A  76
SER A  80
PHE A 164
 None
 1.21A 3snfA-5djqA:
undetectable		 3snfA-5djqA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1) 		PF00296
(Bac_luciferase) 		4 ILE A 140
THR A 127
THR A 126
PHE A  99
 None
 0.86A 3snfA-5dqpA:
undetectable		 3snfA-5dqpA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 ILE A 277
THR A 274
THR A 275
PHE A  22
 None
 0.94A 3snfA-5dt9A:
undetectable		 3snfA-5dt9A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewy PUTATIVE
ADP-RIBOSYLTRANSFERA
SE SCABIN

(Streptomyces
scabiei) 		no annotation 4 ILE A 137
THR A 118
THR A 119
PHE A 163
 None
None
5TQ  A 301 ( 3.8A)
None
 1.06A 3snfA-5ewyA:
undetectable		 3snfA-5ewyA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu4 CBM74-RFGH5

(Ruminococcus
flavefaciens) 		no annotation 4 ILE A 477
THR A 482
SER A 483
PHE A 418
 None
 1.01A 3snfA-5fu4A:
undetectable		 3snfA-5fu4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 4 ILE Y 306
THR Y 327
SER Y 355
PHE Y 353
 None
 1.16A 3snfA-5gaiY:
undetectable		 3snfA-5gaiY:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		4 ILE A 397
THR A 345
THR A 346
PHE A 369
 None
 0.81A 3snfA-5gyzA:
undetectable		 3snfA-5gyzA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ILE A 367
THR A 365
THR A 364
SER A 319
 None
 1.23A 3snfA-5hqlA:
undetectable		 3snfA-5hqlA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		4 ILE A 179
THR A 178
THR A 177
SER A 174
 None
 1.01A 3snfA-5hyhA:
undetectable		 3snfA-5hyhA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		4 ILE A 140
THR A 131
THR A 132
SER A 128
 1YN  A 602 (-4.4A)
1YN  A 602 ( 4.9A)
None
None
 1.07A 3snfA-5jlcA:
undetectable		 3snfA-5jlcA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ken EBOLA SURFACE
GLYCOPROTEIN, GP1
EBOLA SURFACE
GLYCOPROTEIN, GP2

(Zaire
ebolavirus;
Zaire
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		4 ILE A  33
THR B 565
THR B 566
PHE A 183
 None
None
NAG  A 401 ( 4.7A)
None
 1.20A 3snfA-5kenA:
undetectable		 3snfA-5kenA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 ILE B 746
THR B 696
SER B 697
PHE B 700
 None
 0.99A 3snfA-5kyuB:
undetectable		 3snfA-5kyuB:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 397
THR A 345
THR A 346
PHE A 369
 None
 0.90A 3snfA-5kyvA:
undetectable		 3snfA-5kyvA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		4 ILE A 329
THR A 272
THR A 269
PHE A  35
 None
None
None
GOL  A 607 (-4.3A)
 1.16A 3snfA-5l2rA:
undetectable		 3snfA-5l2rA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tro PENICILLIN-BINDING
PROTEIN 1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ILE A 410
THR A 427
THR A 428
PHE A 316
 None
 1.14A 3snfA-5troA:
undetectable		 3snfA-5troA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		no annotation 4 ILE A 476
THR A 469
THR A 468
SER A 467
 None
 1.19A 3snfA-5u8qA:
undetectable		 3snfA-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uvq SCABIN

(Streptomyces
scabiei) 		no annotation 4 ILE A 137
THR A 118
THR A 119
PHE A 163
 None
 1.07A 3snfA-5uvqA:
undetectable		 3snfA-5uvqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila) 		no annotation 4 ILE A 287
THR A 283
THR A 284
SER A 135
 None
 1.08A 3snfA-5w11A:
undetectable		 3snfA-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 ILE A 216
THR A 340
THR A 339
SER A 342
 None
 1.22A 3snfA-5w81A:
undetectable		 3snfA-5w81A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy3 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 THR A 173
THR A 174
SER A 175
PHE A 239
 None
 1.15A 3snfA-5wy3A:
undetectable		 3snfA-5wy3A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 4 ILE B 130
THR B   7
THR B   6
SER B   5
 None
 1.21A 3snfA-5y58B:
undetectable		 3snfA-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 4 ILE B 130
THR B   7
THR B   6
SER B   5
 None
 1.21A 3snfA-5y59B:
undetectable		 3snfA-5y59B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap1 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4,PROTEIN
HCP1

(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		no annotation 4 ILE A 354
THR A 389
SER A 387
PHE A 360
 None
 1.21A 3snfA-6ap1A:
undetectable		 3snfA-6ap1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 ILE A 930
THR A 857
THR A 854
SER A 853
 None
 1.19A 3snfA-6b3rA:
undetectable		 3snfA-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB

(Yersinia
pseudotuberculosis) 		no annotation 4 ILE A 126
THR A 131
THR A 130
PHE A  68
 ILE  A 126 ( 0.7A)
THR  A 131 ( 0.8A)
THR  A 130 ( 0.8A)
PHE  A  68 ( 1.3A)
 0.89A 3snfA-6gefA:
undetectable		 3snfA-6gefA:
undetectable