SIMILAR PATTERNS OF AMINO ACIDS FOR 3SJ4_X_DXCX75

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)

(Homo sapiens) 		PF00079
(Serpin) 		5 ILE A 114
LEU A 407
PHE A 204
LYS A 207
GLY A 206
 None
 1.47A 3sj4X-1by7A:
undetectable		 3sj4X-1by7A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckm MRNA CAPPING ENZYME

(Paramecium
bursaria
Chlorella virus
1) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		5 ILE A  26
LEU A 113
ILE A 184
PHE A 143
GLY A 130
 None
 1.15A 3sj4X-1ckmA:
undetectable		 3sj4X-1ckmA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		5 ILE A 242
LYS A 220
ILE A 259
MET A 283
GLY A 263
 None
None
None
None
SO4  A 600 (-3.4A)
 1.37A 3sj4X-1eepA:
undetectable		 3sj4X-1eepA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f89 32.5 KDA PROTEIN
YLR351C

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		5 ILE A  11
LEU A   7
ILE A 190
LYS A 184
GLY A 185
 None
 1.27A 3sj4X-1f89A:
undetectable		 3sj4X-1f89A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 ILE A 767
LEU A 633
ILE A 676
MET A 673
GLY A 672
 None
 1.40A 3sj4X-1i8qA:
undetectable		 3sj4X-1i8qA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr4 PROTEIN TM1056, CUTA

(Thermotoga
maritima) 		PF03091
(CutA1) 		5 ILE A  86
LEU A  75
LYS A  62
ILE A   8
PHE A  61
 None
 1.40A 3sj4X-1kr4A:
undetectable		 3sj4X-1kr4A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leh LEUCINE
DEHYDROGENASE

(Lysinibacillus
sphaericus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 ILE A 360
LEU A 298
ILE A 292
LYS A  80
GLY A  41
 None
 1.47A 3sj4X-1lehA:
undetectable		 3sj4X-1lehA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5j PERIPLASMIC DIVALENT
CATION TOLERANCE
PROTEIN

(Thermotoga
maritima) 		PF03091
(CutA1) 		5 ILE A  80
LEU A  69
LYS A  56
ILE A   2
PHE A  55
 None
 1.33A 3sj4X-1o5jA:
undetectable		 3sj4X-1o5jA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Escherichia
coli;
Drosophila
melanogaster) 		no annotation 5 ILE P 131
LEU P 197
LYS P 255
ILE P 225
GLY P 190
 None
 1.32A 3sj4X-1r6zP:
undetectable		 3sj4X-1r6zP:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A 309
LEU A 314
ILE A 116
PHE A 274
GLY A 273
 None
 1.09A 3sj4X-1rblA:
undetectable		 3sj4X-1rblA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 ILE A 182
LEU A 216
ILE A 190
PHE A 238
GLY A 245
 None
 1.12A 3sj4X-1w27A:
undetectable		 3sj4X-1w27A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 ILE A 182
LEU A 216
ILE A 190
PHE A 238
GLY A 246
 None
 1.23A 3sj4X-1w27A:
undetectable		 3sj4X-1w27A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01008
(IF-2B)
PF01008
(IF-2B) 		5 ILE B 282
LEU B 407
LYS A 153
ILE B 391
PHE B 397
 None
 1.20A 3sj4X-1w2wB:
undetectable		 3sj4X-1w2wB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsa BIS(5'-NUCLEOSYL)-TE
TRAPHOSPHATASE

(Homo sapiens) 		PF00293
(NUDIX) 		5 ILE A  78
LEU A 147
LYS A  47
ILE A  15
PHE A  31
 None
 1.41A 3sj4X-1xsaA:
undetectable		 3sj4X-1xsaA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		5 ILE A 383
LEU A 385
ILE A 395
PHE A 390
GLY A 414
 None
 1.44A 3sj4X-2bmfA:
undetectable		 3sj4X-2bmfA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		5 ILE A 270
LEU A 351
ILE A 297
MET A  53
GLY A  49
 None
 1.19A 3sj4X-2cycA:
undetectable		 3sj4X-2cycA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 ILE A 135
LEU A 173
ILE A 235
MET A  87
GLY A 170
 None
 1.45A 3sj4X-2eb5A:
undetectable		 3sj4X-2eb5A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		5 ILE A 999
LEU A1030
ILE A 939
PHE A1037
GLY A 911
 None
 1.29A 3sj4X-2ec5A:
undetectable		 3sj4X-2ec5A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhk FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Methanopyrus
kandleri) 		PF01913
(FTR)
PF02741
(FTR_C) 		5 ILE A  25
ILE A  77
PHE A 158
LYS A 123
GLY A 121
 None
None
None
MFN  A 600 (-4.0A)
None
 1.41A 3sj4X-2fhkA:
undetectable		 3sj4X-2fhkA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnx HYPOTHETICAL PROTEIN

(Mus musculus) 		PF09404
(DUF2003) 		5 ILE A 404
LEU A 426
LYS A 412
ILE A 420
PHE A 422
 None
 1.27A 3sj4X-2gnxA:
undetectable		 3sj4X-2gnxA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gti REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF06471
(NSP11) 		5 ILE A 142
LEU A 125
ILE A 137
PHE A 128
LYS A 177
 None
SO4  A 503 (-4.0A)
None
None
None
 1.46A 3sj4X-2gtiA:
undetectable		 3sj4X-2gtiA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcz BETA-EXPANSIN 1A

(Zea mays) 		PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1) 		5 ILE X 152
LEU X 161
LYS X 225
PHE X 210
GLY X 208
 None
 1.01A 3sj4X-2hczX:
undetectable		 3sj4X-2hczX:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		5 ILE A 167
LEU A  68
ILE A  29
LYS A  90
GLY A  91
 None
 1.44A 3sj4X-2i7tA:
undetectable		 3sj4X-2i7tA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		5 LEU A  41
LYS A 167
PHE A  12
MET A   9
LYS A   5
 None
 1.29A 3sj4X-2oryA:
undetectable		 3sj4X-2oryA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2peg HEMOGLOBIN SUBUNIT
BETA

(Trematomus
bernacchii) 		PF00042
(Globin) 		5 ILE B 110
LEU B 134
PHE B 133
MET B  78
GLY B  74
 None
 1.32A 3sj4X-2pegB:
undetectable		 3sj4X-2pegB:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		5 ILE A 234
LEU A 201
ILE A 217
PHE A 188
GLY A 208
 None
 1.36A 3sj4X-2pfkA:
undetectable		 3sj4X-2pfkA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		5 ILE A 160
LEU A 185
ILE A 268
PHE A 233
GLY A 231
 None
 1.16A 3sj4X-2qe6A:
undetectable		 3sj4X-2qe6A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv0 PROTEIN MRKE

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		5 ILE A 125
LEU A  99
ILE A 113
PHE A  89
GLY A  87
 None
 0.96A 3sj4X-2qv0A:
undetectable		 3sj4X-2qv0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmy PUTATIVE ACID
PHOSPHATASE WZB

(Escherichia
coli) 		PF01451
(LMWPc) 		5 ILE A   9
LEU A  27
ILE A  12
PHE A 108
GLY A 109
 None
 1.17A 3sj4X-2wmyA:
undetectable		 3sj4X-2wmyA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		5 ILE A 116
LEU A 114
LYS A 125
PHE A 126
GLY A  63
 None
 1.10A 3sj4X-2xn6A:
undetectable		 3sj4X-2xn6A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine leukemia
virus) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 ILE A 158
LEU A 224
LYS A 282
ILE A 252
GLY A 217
 None
 1.23A 3sj4X-2xz3A:
undetectable		 3sj4X-2xz3A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		5 ILE A 218
LEU A 181
ILE A 209
MET A 394
GLY A 393
 None
 1.27A 3sj4X-3anyA:
undetectable		 3sj4X-3anyA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE

(Pyrococcus sp.
GI-H) 		PF09019
(EcoRII-C) 		5 ILE A 253
LEU A 112
ILE A 140
PHE A 139
LYS A 160
 None
 1.34A 3sj4X-3bm3A:
undetectable		 3sj4X-3bm3A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		5 ILE A 176
LEU A 180
ILE A 139
PHE A 147
GLY A 148
 None
 1.41A 3sj4X-3cg3A:
undetectable		 3sj4X-3cg3A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		5 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.27A 3sj4X-3dm0A:
undetectable		 3sj4X-3dm0A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpu RAB FAMILY PROTEIN

(Chlorobaculum
tepidum) 		PF08477
(Roc)
PF16095
(COR) 		5 ILE A 555
LEU A 538
LYS A 486
MET A 462
GLY A 461
 None
 1.34A 3sj4X-3dpuA:
undetectable		 3sj4X-3dpuA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3s LAMBDA-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 ILE A 179
LEU A 175
LYS A  33
ILE A  11
GLY A   7
 None
 1.08A 3sj4X-3f3sA:
undetectable		 3sj4X-3f3sA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis) 		PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1) 		5 ILE A 364
LEU A 705
LYS A 354
ILE A 353
GLY A 394
 None
 0.81A 3sj4X-3la4A:
undetectable		 3sj4X-3la4A:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq9 BONE MARROW STROMAL
ANTIGEN 2 FUSED TO
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16716
(BST2) 		5 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.16A 3sj4X-3mq9A:
undetectable		 3sj4X-3mq9A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 ILE A-238
LEU A-172
LYS A-114
ILE A-144
GLY A-179
 None
 1.22A 3sj4X-3n93A:
undetectable		 3sj4X-3n93A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 ILE B 407
LEU B 372
LYS B 256
ILE B 403
LYS B 395
 None
None
FAD  B 606 (-3.9A)
FAD  B 606 ( 4.1A)
None
 1.28A 3sj4X-3ns1B:
undetectable		 3sj4X-3ns1B:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		5 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.26A 3sj4X-3oaiA:
undetectable		 3sj4X-3oaiA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Escherichia
coli;
Arachis
duranensis) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		5 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.23A 3sj4X-3ob4A:
undetectable		 3sj4X-3ob4A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r89 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Anaerococcus
prevotii) 		PF00215
(OMPdecase) 		5 ILE A  59
LEU A   7
ILE A 221
MET A 217
GLY A 196
 None
 1.30A 3sj4X-3r89A:
undetectable		 3sj4X-3r89A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4b STARVATION SENSING
PROTEIN RSPA

(Cellvibrio
japonicus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ILE A  52
LEU A  20
ILE A  66
MET A  83
GLY A  82
 None
 1.30A 3sj4X-3v4bA:
undetectable		 3sj4X-3v4bA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3s 6-PHOSPHOFRUCTOKINAS
E

(Bacillus
subtilis) 		PF00365
(PFK) 		5 ILE A 286
LEU A 267
ILE A 130
MET A  16
GLY A  15
 None
 1.32A 3sj4X-4a3sA:
undetectable		 3sj4X-4a3sA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4p F18 FIMBRIAL ADHESIN
AC

(Escherichia
coli) 		no annotation 5 ILE A  73
LEU A 133
ILE A  40
LYS A  18
GLY A  17
 None
 1.35A 3sj4X-4b4pA:
undetectable		 3sj4X-4b4pA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		5 ILE A 133
LEU A 199
LYS A 257
ILE A 227
GLY A 192
 None
 1.17A 3sj4X-4edqA:
undetectable		 3sj4X-4edqA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		5 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.26A 3sj4X-4exkA:
undetectable		 3sj4X-4exkA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1j SORTASE FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF04203
(Sortase) 		5 ILE A 128
LEU A 160
ILE A 118
PHE A 184
GLY A 239
 None
 1.34A 3sj4X-4g1jA:
undetectable		 3sj4X-4g1jA:
15.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hc3 PPCA

(Geobacter
sulfurreducens) 		no annotation 9 ILE A   4
LEU A   6
LYS A  33
LYS A  37
ILE A  38
PHE A  41
MET A  45
LYS A  49
GLY A  50
 HEM  A  72 (-4.4A)
HEM  A  74 ( 3.7A)
DXC  A  75 ( 4.4A)
DXC  A  75 ( 2.6A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 4.3A)
DXC  A  75 (-4.2A)
DXC  A  75 ( 4.1A)
DXC  A  75 ( 3.7A)
 0.38A 3sj4X-4hc3A:
15.6		 3sj4X-4hc3A:
97.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		5 ILE A 417
LEU A 385
MET A 359
LYS A 337
GLY A 358
 None
 1.21A 3sj4X-4hwvA:
undetectable		 3sj4X-4hwvA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E

(Geobacillus
stearothermophilus) 		PF00365
(PFK) 		5 ILE A 286
LEU A 267
ILE A 130
MET A  16
GLY A  15
 None
 1.33A 3sj4X-4i4iA:
undetectable		 3sj4X-4i4iA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 ILE A 133
LEU A 199
LYS A 257
ILE A 227
GLY A 192
 None
 1.28A 3sj4X-4ikmA:
undetectable		 3sj4X-4ikmA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI

(Escherichia
coli) 		PF13561
(adh_short_C2) 		5 ILE A  59
LEU A  78
LYS A   7
PHE A  85
GLY A  87
 None
 1.27A 3sj4X-4jx8A:
undetectable		 3sj4X-4jx8A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kma GM14141P

(Drosophila
melanogaster) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		5 ILE A 450
LEU A 448
PHE A 422
MET A 419
LYS A 363
 None
 1.29A 3sj4X-4kmaA:
undetectable		 3sj4X-4kmaA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF08817
(YukD)
PF13416
(SBP_bac_8) 		5 ILE A 133
LEU A 199
LYS A 257
ILE A 227
GLY A 192
 None
 1.21A 3sj4X-4kv3A:
undetectable		 3sj4X-4kv3A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		5 ILE A 168
LEU A 114
ILE A  74
PHE A  63
GLY A  70
 None
 1.43A 3sj4X-4m2gA:
undetectable		 3sj4X-4m2gA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		5 ILE A 168
LEU A 114
LYS A   9
PHE A  63
GLY A  70
 None
 1.26A 3sj4X-4m2gA:
undetectable		 3sj4X-4m2gA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n13 PHOSPHATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Borreliella
burgdorferi) 		PF12849
(PBP_like_2) 		5 ILE A 139
LEU A 107
LYS A 172
PHE A 126
GLY A 160
 None
None
None
EDO  A 305 ( 4.5A)
EDO  A 305 (-2.6A)
 1.30A 3sj4X-4n13A:
undetectable		 3sj4X-4n13A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		5 ILE A 225
LEU A 285
LYS A 329
ILE A 331
GLY A 324
 None
 1.37A 3sj4X-4nesA:
undetectable		 3sj4X-4nesA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozq CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND KINESIN FAMILY
MEMBER 14 PROTEIN

(Escherichia
coli;
Mus musculus) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 ILE A-238
LEU A-172
LYS A-114
ILE A-144
GLY A-179
 None
 1.26A 3sj4X-4ozqA:
undetectable		 3sj4X-4ozqA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		5 ILE A 174
LEU A  74
PHE A 301
MET A 143
GLY A 144
 None
 1.24A 3sj4X-4p9nA:
undetectable		 3sj4X-4p9nA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phx PROTEIN AGGB

(Escherichia
coli) 		no annotation 5 ILE B   3
LEU B   5
ILE B  92
MET B  96
LYS B  65
 None
 1.47A 3sj4X-4phxB:
undetectable		 3sj4X-4phxB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py9 PUTATIVE
EXOPOLYPHOSPHATASE-R
ELATED PROTEIN

(Bacteroides
fragilis) 		PF01368
(DHH) 		5 ILE A  26
LEU A  98
ILE A 153
MET A 174
GLY A 173
 None
 1.27A 3sj4X-4py9A:
undetectable		 3sj4X-4py9A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzl ADENYLATE KINASE

(Francisella
tularensis) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 ILE A  20
LEU A  82
LYS A 197
ILE A 196
GLY A   7
 None
None
FMT  A 302 ( 4.6A)
None
None
 0.97A 3sj4X-4pzlA:
undetectable		 3sj4X-4pzlA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1

(Escherichia
coli;
Rattus
norvegicus) 		PF03359
(GKAP)
PF13416
(SBP_bac_8) 		5 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.24A 3sj4X-4r0yA:
undetectable		 3sj4X-4r0yA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tjv VACUOLAR-SORTING
RECEPTOR 1

(Arabidopsis
thaliana) 		PF02225
(PA) 		5 ILE A 151
LEU A  28
ILE A 115
PHE A  90
GLY A  58
 None
 1.35A 3sj4X-4tjvA:
undetectable		 3sj4X-4tjvA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		5 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.27A 3sj4X-4tsmA:
undetectable		 3sj4X-4tsmA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 ILE A 163
LEU A 322
ILE A 158
PHE A 156
GLY A 109
 None
 1.20A 3sj4X-4us4A:
undetectable		 3sj4X-4us4A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 ILE A 156
LEU A 222
LYS A 280
ILE A 250
GLY A 215
 None
 1.09A 3sj4X-4wrnA:
undetectable		 3sj4X-4wrnA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		5 ILE A 138
LEU A 204
LYS A 262
ILE A 232
GLY A 197
 None
 1.23A 3sj4X-4wviA:
undetectable		 3sj4X-4wviA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		5 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.19A 3sj4X-4xa2A:
undetectable		 3sj4X-4xa2A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd0 TDP-3-AMINOQUINOVOSE
-N-FORMYLTRANSFERASE

(Providencia
alcalifaciens) 		PF00551
(Formyl_trans_N)
PF12796
(Ank_2) 		5 ILE A  90
ILE A  79
PHE A  76
LYS A   8
GLY A   7
 None
FON  A 402 (-4.0A)
None
T3F  A 403 (-3.2A)
None
 1.30A 3sj4X-4xd0A:
undetectable		 3sj4X-4xd0A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
IRON-SULFUR SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 ILE C  94
LEU C 121
LYS C  65
ILE C  58
GLY C 135
 None
None
FES  C 201 ( 4.5A)
None
None
 1.15A 3sj4X-4zohC:
undetectable		 3sj4X-4zohC:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 5 ILE A 288
LEU A 269
ILE A 266
PHE A  89
GLY A  88
 None
 1.14A 3sj4X-5ah1A:
undetectable		 3sj4X-5ah1A:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		6 ILE A 103
LEU A  99
ILE A  84
PHE A  97
MET A 185
GLY A 184
 None
 1.25A 3sj4X-5bptA:
undetectable		 3sj4X-5bptA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Escherichia
coli;
Acinetobacter
nosocomialis) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		5 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.25A 3sj4X-5cfvA:
undetectable		 3sj4X-5cfvA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 5 ILE C 438
LEU C 441
ILE C 378
PHE C 366
GLY C 365
 None
 1.25A 3sj4X-5gp4C:
undetectable		 3sj4X-5gp4C:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 ILE A 133
LEU A 199
LYS A 257
ILE A 227
GLY A 192
 None
 1.22A 3sj4X-5h7nA:
undetectable		 3sj4X-5h7nA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE

(Thermotoga
maritima) 		PF01553
(Acyltransferase) 		5 ILE A  49
LEU A 121
ILE A  93
PHE A 102
LYS A 105
 None
 1.49A 3sj4X-5kymA:
undetectable		 3sj4X-5kymA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		5 ILE A  57
LEU A  53
LYS A  43
PHE A  20
GLY A  13
 CR2  A  59 ( 4.2A)
None
None
None
None
 1.39A 3sj4X-5ltqA:
undetectable		 3sj4X-5ltqA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 5 LEU A 345
LYS A 301
ILE A 395
PHE A 397
GLY A 399
 None
 1.43A 3sj4X-5mz9A:
undetectable		 3sj4X-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue7 PHOSPHOMANNOMUTASE

(Candida
albicans) 		PF03332
(PMM) 		5 ILE A  28
LEU A  60
ILE A  45
PHE A  47
GLY A  49
 None
 1.40A 3sj4X-5ue7A:
undetectable		 3sj4X-5ue7A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcb PROBABLE SURFACE
PROTEIN

(Clostridium
perfringens) 		no annotation 5 ILE A 154
LYS A 109
ILE A 111
PHE A  78
GLY A  85
 None
 1.43A 3sj4X-5xcbA:
undetectable		 3sj4X-5xcbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		5 LEU A1510
ILE A1496
PHE A1488
MET A1470
GLY A1469
 None
 1.42A 3sj4X-5xsyA:
undetectable		 3sj4X-5xsyA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 5 ILE A 212
LEU A 278
LYS A 336
ILE A 306
GLY A 271
 None
 1.26A 3sj4X-6anvA:
undetectable		 3sj4X-6anvA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bze B-CELL
LYMPHOMA/LEUKEMIA 10

(Homo sapiens) 		no annotation 5 ILE A  32
LEU A  69
LYS A  45
LYS A  77
GLY A  78
 None
 1.41A 3sj4X-6bzeA:
undetectable		 3sj4X-6bzeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9w PROTEIN LSM14
HOMOLOG A

(Homo sapiens) 		no annotation 5 ILE A  12
LEU A  38
LYS A  17
ILE A  15
GLY A  69
 None
 1.37A 3sj4X-6f9wA:
undetectable		 3sj4X-6f9wA:
undetectable