SIMILAR PATTERNS OF AMINO ACIDS FOR 3SI7_D_ACTD5

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 LYS A  86
SER A 372
SER A 373
GLN A 369
 None
 1.19A 3si7C-2bf4A:
0.0
3si7D-2bf4A:
0.0		 3si7C-2bf4A:
17.44
3si7D-2bf4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 SER A 373
GLN A 369
LYS A  86
SER A 372
 None
 1.17A 3si7C-2bf4A:
0.0
3si7D-2bf4A:
0.0		 3si7C-2bf4A:
17.44
3si7D-2bf4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pro ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF02983
(Pro_Al_protease) 		4 SER A  68
GLN A  47
SER A  87
GLN A  90
 None
 1.05A 3si7C-2proA:
0.0
3si7D-2proA:
0.0		 3si7C-2proA:
21.51
3si7D-2proA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pro ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF02983
(Pro_Al_protease) 		4 SER A  87
GLN A  90
SER A  68
GLN A  47
 None
 1.11A 3si7C-2proA:
0.0
3si7D-2proA:
0.0		 3si7C-2proA:
21.51
3si7D-2proA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 SER A 325
GLN A 324
SER A 328
GLN A 332
 None
 1.39A 3si7C-2vsqA:
0.4
3si7D-2vsqA:
0.0		 3si7C-2vsqA:
13.17
3si7D-2vsqA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 SER A 328
GLN A 332
SER A 325
GLN A 324
 None
 1.39A 3si7C-2vsqA:
0.4
3si7D-2vsqA:
0.0		 3si7C-2vsqA:
13.17
3si7D-2vsqA:
13.17