SIMILAR PATTERNS OF AMINO ACIDS FOR 3SI7_B_ACTB4_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1br2 MYOSIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 GLY A 180
GLY A 182
THR A 184
 ADP  A 998 (-3.8A)
ADP  A 998 (-3.3A)
MG  A 997 ( 3.0A)
 0.44A 3si7B-1br2A:
0.0		 3si7B-1br2A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		3 GLY A 176
GLY A 178
THR A 180
 PLP  A 501 (-3.5A)
PLP  A 501 (-3.6A)
PLP  A 501 (-3.6A)
 0.23A 3si7B-1d6sA:
undetectable		 3si7B-1d6sA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 GLY A 198
GLY A 200
THR A 202
 SAH  A1699 ( 3.9A)
None
None
 0.29A 3si7B-1fp2A:
undetectable		 3si7B-1fp2A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fts FTSY

(Escherichia
coli) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 GLY A 303
GLY A 305
THR A 307
 None
 0.45A 3si7B-1ftsA:
2.0		 3si7B-1ftsA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g29 MALTOSE TRANSPORT
PROTEIN MALK

(Thermococcus
litoralis) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 GLY 1  39
GLY 1  41
THR 1  43
 POP  1 501 (-3.2A)
POP  1 501 (-3.1A)
POP  1 501 ( 4.1A)
 0.44A 3si7B-1g291:
15.6		 3si7B-1g291:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g60 ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA

(Moraxella bovis) 		PF01555
(N6_N4_Mtase) 		3 GLY A 222
GLY A 224
THR A 226
 SAM  A 500 (-3.2A)
None
None
 0.36A 3si7B-1g60A:
0.2		 3si7B-1g60A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6o CAG-ALPHA

(Helicobacter
pylori) 		PF00437
(T2SSE) 		3 GLY A 181
GLY A 183
THR A 185
 ADP  A 401 (-3.2A)
ADP  A 401 (-3.2A)
ADP  A 401 (-3.5A)
 0.43A 3si7B-1g6oA:
5.9		 3si7B-1g6oA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		3 GLY A 182
GLY A 184
THR A 186
 ADP  A1100 (-3.6A)
ADP  A1100 (-3.2A)
MG  A1101 ( 3.4A)
 0.42A 3si7B-1g8xA:
0.0		 3si7B-1g8xA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htw HI0065

(Haemophilus
influenzae) 		PF02367
(TsaE) 		3 GLY A  43
GLY A  45
THR A  47
 ADP  A 560 (-3.5A)
ADP  A 560 (-3.3A)
MG  A 561 ( 3.1A)
 0.43A 3si7B-1htwA:
4.7		 3si7B-1htwA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		3 GLY A 540
GLY A 538
THR A 601
 None
 0.43A 3si7B-1i5pA:
undetectable		 3si7B-1i5pA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i84 SMOOTH MUSCLE MYOSIN
HEAVY CHAIN

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		3 GLY S 180
GLY S 182
THR S 184
 None
 0.45A 3si7B-1i84S:
undetectable		 3si7B-1i84S:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		3 GLY A  18
GLY A  20
THR A  22
 ADP  A 590 (-3.3A)
ADP  A 590 (-3.1A)
MG  A 592 ( 3.2A)
 0.44A 3si7B-1ii0A:
undetectable		 3si7B-1ii0A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		3 GLY A 337
GLY A 339
THR A 341
 ATP  A 591 (-3.6A)
ATP  A 591 (-3.2A)
MG  A 593 ( 3.2A)
 0.46A 3si7B-1ii0A:
undetectable		 3si7B-1ii0A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1in8 HOLLIDAY JUNCTION
DNA HELICASE RUVB

(Thermotoga
maritima) 		PF05491
(RuvB_C)
PF05496
(RuvB_N) 		3 GLY A  61
GLY A  63
THR A  65
 ADP  A 700 (-3.5A)
ADP  A 700 (-3.1A)
ADP  A 700 (-3.7A)
 0.44A 3si7B-1in8A:
4.9		 3si7B-1in8A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A 100
GLY A 102
THR A 104
 None
 0.42A 3si7B-1inlA:
undetectable		 3si7B-1inlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ion PROBABLE CELL
DIVISION INHIBITOR
MIND

(Pyrococcus
horikoshii) 		PF13614
(AAA_31) 		3 GLY A  13
GLY A  15
THR A  17
 ADP  A 301 (-3.5A)
ADP  A 301 (-3.0A)
MG  A 302 ( 3.4A)
 0.45A 3si7B-1ionA:
undetectable		 3si7B-1ionA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0a 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pyrococcus
horikoshii) 		PF00291
(PALP) 		3 GLY A 190
GLY A 192
THR A 194
 PLP  A 401 (-3.6A)
PLP  A 401 (-3.7A)
PLP  A 401 (-3.8A)
 0.29A 3si7B-1j0aA:
undetectable		 3si7B-1j0aA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbk CLPB PROTEIN

(Escherichia
coli) 		PF00004
(AAA) 		3 GLY A 209
GLY A 211
THR A 213
 MG  A   1 (-4.0A)
MG  A   1 (-4.0A)
MG  A   1 ( 4.7A)
 0.45A 3si7B-1jbkA:
4.7		 3si7B-1jbkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeo HYPOTHETICAL PROTEIN
MJ1247

(Methanocaldococcus
jannaschii) 		PF01380
(SIS) 		3 GLY A  91
GLY A  93
THR A  95
 CIT  A3000 (-3.6A)
None
CIT  A3000 (-3.5A)
 0.38A 3si7B-1jeoA:
undetectable		 3si7B-1jeoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 GLY A 193
GLY A 195
THR A 197
 ADP  A1203 (-3.4A)
ADP  A1203 (-3.1A)
MG  A1202 ( 3.1A)
 0.45A 3si7B-1jx2A:
undetectable		 3si7B-1jx2A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 GLY A  74
GLY A  76
THR A  78
 SAH  A1900 (-3.2A)
None
None
 0.23A 3si7B-1kphA:
undetectable		 3si7B-1kphA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 GLY A  82
GLY A  84
THR A  86
 SAH  A 900 (-3.1A)
None
None
 0.23A 3si7B-1kpiA:
undetectable		 3si7B-1kpiA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ky3 GTP-BINDING PROTEIN
YPT7P

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		3 GLY A  18
GLY A  20
THR A  22
 GDP  A 400 (-3.6A)
GDP  A 400 (-3.2A)
MG  A 401 ( 3.1A)
 0.45A 3si7B-1ky3A:
undetectable		 3si7B-1ky3A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1e MYCOLIC ACID
SYNTHASE

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 GLY A  74
GLY A  76
THR A  78
 SAH  A 900 (-3.4A)
None
None
 0.23A 3si7B-1l1eA:
undetectable		 3si7B-1l1eA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3s HYPOTHETICAL PROTEIN
YCKF

(Bacillus
subtilis) 		PF01380
(SIS) 		3 GLY A  87
GLY A  89
THR A  91
 None
 0.26A 3si7B-1m3sA:
undetectable		 3si7B-1m3sA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mjf SPERMIDINE SYNTHASE

(Pyrococcus
furiosus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		3 GLY A  84
GLY A  86
THR A  88
 None
 0.38A 3si7B-1mjfA:
undetectable		 3si7B-1mjfA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		3 GLY A  28
GLY A  30
THR A  32
 GDP  A 184 (-3.7A)
GDP  A 184 (-2.8A)
GDP  A 184 (-3.6A)
 0.41A 3si7B-1mozA:
undetectable		 3si7B-1mozA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		3 GLY A 560
GLY A 562
THR A 564
 GOL  A 759 ( 4.1A)
None
None
 0.43A 3si7B-1mqqA:
undetectable		 3si7B-1mqqA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		3 GLY A 252
GLY A 254
THR A 256
 SAM  A 401 (-3.3A)
None
None
 0.36A 3si7B-1nw5A:
undetectable		 3si7B-1nw5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		3 GLY A  22
GLY A  24
THR A  26
 ADP  A 400 ( 3.5A)
ADP  A 400 (-3.0A)
ADP  A 400 (-3.6A)
 0.39A 3si7B-1osnA:
2.5		 3si7B-1osnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLY A  97
GLY A  99
THR A 101
 None
 0.43A 3si7B-1pxtA:
undetectable		 3si7B-1pxtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzn DNA REPAIR AND
RECOMBINATION
PROTEIN RAD51

(Pyrococcus
furiosus) 		PF08423
(Rad51)
PF14520
(HHH_5) 		3 GLY A 141
GLY A 143
THR A 145
 SO4  A 350 (-3.3A)
SO4  A 350 (-3.2A)
SO4  A 350 (-3.5A)
 0.41A 3si7B-1pznA:
undetectable		 3si7B-1pznA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 GLY A 348
GLY A 390
THR A 380
 None
 0.00A 3si7B-1q5aA:
undetectable		 3si7B-1q5aA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 GLY A 392
GLY A 390
THR A 380
 None
 0.00A 3si7B-1q5aA:
undetectable		 3si7B-1q5aA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 GLY X 217
GLY X 219
THR X 221
 ADP  X 780 (-3.6A)
ADP  X 780 (-3.1A)
MG  X 782 ( 3.2A)
 0.45A 3si7B-1r6bX:
3.7		 3si7B-1r6bX:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkb PROTEIN AD-004

(Homo sapiens) 		PF13238
(AAA_18) 		3 GLY A  13
GLY A  15
THR A  17
 SO4  A 201 (-3.5A)
SO4  A 201 (-3.3A)
SO4  A 201 (-3.8A)
 0.41A 3si7B-1rkbA:
3.4		 3si7B-1rkbA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgw PUTATIVE ABC
TRANSPORTER

(Pyrococcus
furiosus) 		PF00005
(ABC_tran) 		3 GLY A  37
GLY A  39
THR A  41
 CL  A 207 (-3.7A)
CL  A 207 (-4.0A)
None
 0.43A 3si7B-1sgwA:
17.5		 3si7B-1sgwA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 GLY A  74
GLY A  76
THR A  78
 SAH  A1900 (-3.3A)
None
None
 0.23A 3si7B-1tpyA:
undetectable		 3si7B-1tpyA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uan HYPOTHETICAL PROTEIN
TT1542

(Thermus
thermophilus) 		PF02585
(PIG-L) 		3 GLY A  17
GLY A  19
THR A  21
 None
 0.45A 3si7B-1uanA:
undetectable		 3si7B-1uanA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		3 GLY A 384
GLY A 386
THR A 388
 MG  A1552 ( 4.8A)
None
ANP  A1551 (-3.7A)
 0.36A 3si7B-1un9A:
undetectable		 3si7B-1un9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve1 O-ACETYLSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF00291
(PALP) 		3 GLY A 175
GLY A 177
THR A 179
 PLP  A 413 (-3.5A)
PLP  A 413 (-3.8A)
PLP  A 413 (-3.5A)
 0.31A 3si7B-1ve1A:
undetectable		 3si7B-1ve1A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpl ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 GLY A  39
GLY A  41
THR A  43
 SO4  A 245 (-3.5A)
SO4  A 245 (-3.3A)
SO4  A 245 (-3.9A)
 0.44A 3si7B-1vplA:
17.3		 3si7B-1vplA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrb PUTATIVE ASPARAGINYL
HYDROXYLASE

(Bacillus
subtilis) 		PF08007
(Cupin_4) 		3 GLY A  35
GLY A 213
THR A 211
 None
 0.32A 3si7B-1vrbA:
undetectable		 3si7B-1vrbA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrp CREATINE KINASE, M
CHAIN

(Tetronarce
californica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 GLY A 331
GLY A 323
THR A 327
 None
 0.46A 3si7B-1vrpA:
undetectable		 3si7B-1vrpA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Mus musculus) 		PF00005
(ABC_tran)
PF14396
(CFTR_R) 		3 GLY A 542
GLY A 545
THR A 547
 ACY  A   7 (-3.3A)
ACY  A   7 (-3.0A)
ACY  A   7 ( 3.1A)
 0.12A 3si7B-1xfaA:
27.7		 3si7B-1xfaA:
99.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 3 GLY B  62
GLY B  64
THR B  66
 ADP  B2800 (-3.2A)
ADP  B2800 (-3.4A)
ADP  B2800 (-3.6A)
 0.44A 3si7B-1xnjB:
undetectable		 3si7B-1xnjB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxl YCGJ PROTEIN

(Bacillus
subtilis) 		PF08241
(Methyltransf_11) 		3 GLY A  22
GLY A  24
THR A  26
 None
 0.27A 3si7B-1xxlA:
undetectable		 3si7B-1xxlA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292

(Aquifex
aeolicus) 		PF03266
(NTPase_1) 		3 GLY A  10
GLY A  12
THR A  14
 PO4  A1001 ( 3.3A)
PO4  A1001 (-3.0A)
MG  A1002 ( 3.2A)
 0.44A 3si7B-1ye8A:
5.7		 3si7B-1ye8A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhn RAS-RELATED PROTEIN
RAB-7

(Homo sapiens) 		PF00071
(Ras) 		3 GLY A  18
GLY A  20
THR A  22
 GTP  A 301 (-2.6A)
GTP  A 301 (-2.9A)
MG  A 302 ( 3.3A)
 0.41A 3si7B-1yhnA:
undetectable		 3si7B-1yhnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr7 ATP(GTP)BINDING
PROTEIN

(Pyrococcus
abyssi) 		PF03029
(ATP_bind_1) 		3 GLY A  10
GLY A  12
THR A  14
 GSP  A 401 (-3.7A)
GSP  A 401 (-2.9A)
GSP  A 401 (-2.6A)
 0.44A 3si7B-1yr7A:
undetectable		 3si7B-1yr7A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zu4 FTSY

(Mycoplasma
mycoides) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 GLY A 206
GLY A 208
THR A 210
 SO4  A1130 (-3.8A)
SO4  A1130 (-3.7A)
SO4  A1130 (-3.2A)
 0.37A 3si7B-1zu4A:
undetectable		 3si7B-1zu4A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax4 BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 2

(Homo sapiens) 		PF01583
(APS_kinase) 		3 GLY A  62
GLY A  64
THR A  66
 ADP  A 800 (-3.3A)
ADP  A 800 (-3.3A)
ADP  A 800 (-3.6A)
 0.43A 3si7B-2ax4A:
3.0		 3si7B-2ax4A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bej SEGREGATION PROTEIN

(Thermus
thermophilus) 		PF13614
(AAA_31) 		3 GLY A  17
GLY A  19
THR A  21
 ADP  A 500 (-3.3A)
ADP  A 500 (-3.1A)
MG  A 501 ( 3.1A)
 0.45A 3si7B-2bejA:
undetectable		 3si7B-2bejA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chg REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA) 		3 GLY A  48
GLY A  50
THR A  52
 ANP  A1227 (-3.4A)
ANP  A1227 (-3.2A)
ANP  A1227 (-3.6A)
 0.42A 3si7B-2chgA:
6.0		 3si7B-2chgA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d62 MULTIPLE
SUGAR-BINDING
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 GLY A  42
GLY A  44
THR A  46
 POP  A1293 (-3.2A)
POP  A1293 (-3.1A)
POP  A1293 (-3.9A)
 0.46A 3si7B-2d62A:
15.4		 3si7B-2d62A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 GLY A 166
GLY A 168
THR A 170
 None
 0.40A 3si7B-2dfsA:
undetectable		 3si7B-2dfsA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr3 UPF0273 PROTEIN
PH0284

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		3 GLY A  33
GLY A  35
THR A  37
 ADP  A3801 (-3.4A)
ADP  A3801 (-2.9A)
ADP  A3801 (-3.5A)
 0.43A 3si7B-2dr3A:
7.2		 3si7B-2dr3A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew1 RAS-RELATED PROTEIN
RAB-30

(Homo sapiens) 		PF00071
(Ras) 		3 GLY A  18
GLY A  20
THR A  22
 GNP  A 700 (-3.6A)
GNP  A 700 (-3.1A)
MG  A 701 ( 3.0A)
 0.45A 3si7B-2ew1A:
undetectable		 3si7B-2ew1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		3 GLY A  83
GLY A  85
THR A  87
 None
 0.29A 3si7B-2fk7A:
undetectable		 3si7B-2fk7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6b RAS-RELATED PROTEIN
RAB-26

(Homo sapiens) 		PF00071
(Ras) 		3 GLY A  73
GLY A  75
THR A  77
 GNP  A 302 (-3.6A)
GNP  A 302 (-3.3A)
MG  A 301 ( 3.0A)
 0.45A 3si7B-2g6bA:
undetectable		 3si7B-2g6bA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdj DNA REPAIR AND
RECOMBINATION
PROTEIN RADA

(Methanococcus
voltae) 		PF08423
(Rad51) 		3 GLY A 108
GLY A 110
THR A 112
 ANP  A 401 (-3.2A)
ANP  A 401 (-3.4A)
MG  A 501 ( 3.3A)
 0.43A 3si7B-2gdjA:
6.7		 3si7B-2gdjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gry KINESIN-LIKE PROTEIN
KIF2

(Homo sapiens) 		PF00225
(Kinesin) 		3 GLY A 289
GLY A 291
THR A 293
 ADP  A 601 (-3.5A)
ADP  A 601 (-3.1A)
MG  A 701 ( 3.2A)
 0.42A 3si7B-2gryA:
undetectable		 3si7B-2gryA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcb CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Aquifex
aeolicus) 		PF00308
(Bac_DnaA)
PF08299
(Bac_DnaA_C) 		3 GLY A 122
GLY A 124
THR A 126
 ACP  A 700 (-3.3A)
ACP  A 700 (-3.1A)
MG  A 400 ( 2.9A)
 0.45A 3si7B-2hcbA:
6.1		 3si7B-2hcbA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		3 GLY A  43
GLY A  45
THR A  47
 GSP  A 300 (-3.1A)
GSP  A 300 (-3.2A)
MG  A 301 ( 3.1A)
 0.43A 3si7B-2hf8A:
3.1		 3si7B-2hf8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihy ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Staphylococcus
aureus) 		PF00005
(ABC_tran) 		3 GLY A  38
GLY A  40
THR A  42
 SO4  A 301 (-3.4A)
SO4  A 301 (-3.5A)
SO4  A 301 (-3.9A)
 0.44A 3si7B-2ihyA:
15.7		 3si7B-2ihyA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		3 GLY A 181
GLY A 183
THR A 185
 PLP  A 400 (-3.5A)
PLP  A 400 (-3.4A)
PLP  A 400 (-3.6A)
 0.23A 3si7B-2isqA:
undetectable		 3si7B-2isqA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1l RHO-RELATED
GTP-BINDING PROTEIN
RHOD

(Homo sapiens) 		PF00071
(Ras) 		3 GLY A  27
GLY A  29
THR A  31
 GDP  A1194 (-3.3A)
GDP  A1194 (-3.2A)
MG  A1195 ( 3.4A)
 0.43A 3si7B-2j1lA:
undetectable		 3si7B-2j1lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00156
(Pribosyltran) 		3 GLY A 145
GLY A 147
THR A 149
 5GP  A1230 (-3.3A)
5GP  A1230 (-3.5A)
5GP  A1230 (-3.6A)
 0.24A 3si7B-2jbhA:
undetectable		 3si7B-2jbhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ls5 UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF08534
(Redoxin) 		3 GLY A  73
GLY A  97
THR A  21
 None
 0.44A 3si7B-2ls5A:
undetectable		 3si7B-2ls5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzj GTP-BINDING PROTEIN
REM 1

(Homo sapiens) 		PF00071
(Ras) 		3 GLY A  90
GLY A  92
THR A  94
 GDP  A1001 (-3.7A)
GDP  A1001 (-3.2A)
MG  A 252 ( 3.1A)
 0.46A 3si7B-2nzjA:
undetectable		 3si7B-2nzjA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofx BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		PF01583
(APS_kinase) 		3 GLY A  62
GLY A  64
THR A  66
 ADP  A1300 (-3.4A)
ADP  A1300 (-3.3A)
MG  A 301 ( 3.1A)
 0.44A 3si7B-2ofxA:
2.7		 3si7B-2ofxA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20

(Homo sapiens) 		PF00270
(DEAD) 		3 GLY A 109
GLY A 111
THR A 113
 ADP  A 300 (-3.5A)
ADP  A 300 (-3.2A)
ADP  A 300 (-3.7A)
 0.42A 3si7B-2oxcA:
3.2		 3si7B-2oxcA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pey BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1 (PAPS
SYNTHETASE 1) (PAPSS
1) (SULFURYLASE
KINASE 1) (SK1) (SK
1)

(Homo sapiens) 		PF01583
(APS_kinase) 		3 GLY A  62
GLY A  64
THR A  66
 DAT  A 300 (-3.2A)
DAT  A 300 (-3.2A)
DAT  A 300 (-3.6A)
 0.43A 3si7B-2peyA:
2.9		 3si7B-2peyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjz HYPOTHETICAL PROTEIN
ST1066

(Sulfurisphaera
tokodaii) 		PF00005
(ABC_tran) 		3 GLY A  40
GLY A  42
THR A  44
 SO4  A 502 (-3.5A)
SO4  A 502 (-3.5A)
SO4  A 502 (-3.7A)
 0.44A 3si7B-2pjzA:
11.6		 3si7B-2pjzA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 GLY D 154
GLY D 156
THR D 158
 None
 0.42A 3si7B-2qe7D:
5.6		 3si7B-2qe7D:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyo O-METHYLTRANSFERASE

(Medicago
truncatula) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 GLY A 203
GLY A 205
THR A 207
 SAH  A 601 ( 3.8A)
None
SAH  A 601 (-4.0A)
 0.29A 3si7B-2qyoA:
undetectable		 3si7B-2qyoA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz4 PARAPLEGIN

(Homo sapiens) 		PF00004
(AAA) 		3 GLY A 352
GLY A 354
THR A 356
 ADP  A 700 (-3.6A)
ADP  A 700 (-3.4A)
ADP  A 700 (-3.8A)
 0.45A 3si7B-2qz4A:
4.8		 3si7B-2qz4A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd7 COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF01823
(MACPF) 		3 GLY A 373
GLY A 375
THR A 377
 None
 0.34A 3si7B-2rd7A:
undetectable		 3si7B-2rd7A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		3 GLY A  66
GLY A  68
THR A  70
 ADP  A1400 (-3.8A)
ADP  A1400 (-2.2A)
MG  A1401 ( 3.0A)
 0.43A 3si7B-2v1uA:
6.1		 3si7B-2v1uA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		3 GLY A 154
GLY A 156
THR A 158
 ADP  A1789 ( 3.5A)
ADP  A1789 (-3.1A)
MG  A1801 ( 3.0A)
 0.44A 3si7B-2v26A:
undetectable		 3si7B-2v26A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvg KINESIN-2

(Giardia
intestinalis) 		PF00225
(Kinesin) 		3 GLY A 100
GLY A 102
THR A 104
 ADP  A1351 (-3.5A)
ADP  A1351 (-3.0A)
MG  A1352 ( 3.0A)
 0.43A 3si7B-2vvgA:
undetectable		 3si7B-2vvgA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum) 		no annotation 3 GLY A 154
GLY A 152
THR A 207
 None
PLM  A1278 ( 4.2A)
None
 0.44A 3si7B-2w3yA:
undetectable		 3si7B-2w3yA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w58 PRIMOSOME COMPONENT
(HELICASE LOADER)

(Geobacillus
kaustophilus) 		PF01695
(IstB_IS21) 		3 GLY A 171
GLY A 173
THR A 175
 ADP  A1310 (-3.4A)
ADP  A1310 (-3.4A)
MG  A1311 ( 3.6A)
 0.44A 3si7B-2w58A:
4.9		 3si7B-2w58A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		3 GLY C  94
GLY C  96
THR C  98
 ANP  C1358 (-3.5A)
ANP  C1358 (-3.0A)
MG  C1359 ( 3.2A)
 0.41A 3si7B-2wbeC:
undetectable		 3si7B-2wbeC:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		3 GLY A 196
GLY A 198
THR A 200
 ADP  A1619 (-3.3A)
ADP  A1619 (-3.0A)
MN  A1620 ( 3.3A)
 0.43A 3si7B-2whxA:
5.3		 3si7B-2whxA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		3 GLY A  40
GLY A  42
THR A  44
 None
 0.45A 3si7B-2wsmA:
undetectable		 3si7B-2wsmA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8a NUCLEAR
VALOSIN-CONTAINING
PROTEIN-LIKE

(Homo sapiens) 		PF00004
(AAA) 		3 GLY A 625
GLY A 627
THR A 629
 PO4  A1840 (-3.5A)
PO4  A1840 (-3.4A)
PO4  A1840 (-3.9A)
 0.44A 3si7B-2x8aA:
5.0		 3si7B-2x8aA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsz RUVB-LIKE 1

(Homo sapiens) 		PF06068
(TIP49) 		3 GLY A  87
GLY A  89
THR A  91
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-3.8A)
 0.44A 3si7B-2xszA:
undetectable		 3si7B-2xszA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF13086
(AAA_11)
PF13087
(AAA_12) 		3 GLY A 495
GLY A 497
THR A 499
 ADP  A1004 ( 3.2A)
ADP  A1004 (-3.2A)
MG  A1006 ( 3.3A)
 0.46A 3si7B-2xzoA:
undetectable		 3si7B-2xzoA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvu PROBABLE
ADENYLYL-SULFATE
KINASE

(Aeropyrum
pernix) 		PF01583
(APS_kinase) 		3 GLY A  23
GLY A  25
THR A  27
 None
 0.46A 3si7B-2yvuA:
3.4		 3si7B-2yvuA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyz SUGAR ABC
TRANSPORTER,
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF08402
(TOBE_2) 		3 GLY A  39
GLY A  41
THR A  43
 SO4  A1001 (-3.3A)
SO4  A1001 (-3.4A)
SO4  A1001 (-3.4A)
 0.43A 3si7B-2yyzA:
16.1		 3si7B-2yyzA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0m 337AA LONG
HYPOTHETICAL
ATP-DEPENDENT RNA
HELICASE DEAD

(Sulfurisphaera
tokodaii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 GLY A  41
GLY A  43
THR A  45
 None
 0.44A 3si7B-2z0mA:
3.3		 3si7B-2z0mA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		3 GLY A 245
GLY A 247
THR A 249
 None
 0.38A 3si7B-2zieA:
undetectable		 3si7B-2zieA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		3 GLY A 475
GLY A 673
THR A 677
 None
GLU  A 301 (-3.2A)
None
 0.41A 3si7B-2znsA:
undetectable		 3si7B-2znsA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6u KINESIN-LIKE PROTEIN
KIF3B

(Homo sapiens) 		PF00225
(Kinesin) 		3 GLY A  99
GLY A 101
THR A 103
 ADP  A 402 (-3.5A)
ADP  A 402 (-3.1A)
MG  A 401 ( 3.0A)
 0.44A 3si7B-3b6uA:
undetectable		 3si7B-3b6uA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b6v KINESIN-LIKE PROTEIN
KIF3C

(Homo sapiens) 		PF00225
(Kinesin) 		3 GLY A 100
GLY A 102
THR A 104
 ADP  A1001 (-3.5A)
ADP  A1001 (-3.0A)
MG  A1002 ( 3.3A)
 0.40A 3si7B-3b6vA:
undetectable		 3si7B-3b6vA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A

(Mus musculus) 		PF00071
(Ras) 		3 GLY A  19
GLY A  21
THR A  23
 GNP  A 195 (-3.7A)
GNP  A 195 (-3.3A)
MG  A 194 ( 3.1A)
 0.42A 3si7B-3bc1A:
undetectable		 3si7B-3bc1A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfn KINESIN-LIKE PROTEIN
KIF22

(Homo sapiens) 		PF00225
(Kinesin) 		3 GLY A 130
GLY A 132
THR A 134
 ADP  A 802 (-3.7A)
ADP  A 802 (-3.3A)
MG  A 801 ( 3.1A)
 0.43A 3si7B-3bfnA:
undetectable		 3si7B-3bfnA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1o EUGENOL SYNTHASE

(Clarkia breweri) 		PF05368
(NmrA) 		3 GLY A 178
GLY A 180
THR A 182
 None
 0.42A 3si7B-3c1oA:
undetectable		 3si7B-3c1oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8b FIDGETIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		3 GLY A 444
GLY A 446
THR A 448
 ADP  A 900 (-3.5A)
ADP  A 900 (-3.2A)
ADP  A 900 (-3.8A)
 0.46A 3si7B-3d8bA:
4.2		 3si7B-3d8bA:
23.68