SIMILAR PATTERNS OF AMINO ACIDS FOR 3SFU_C_RBVC601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg2 CARBOXYPEPTIDASE G2

(Pseudomonas sp.
RS-16) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A  74
LEU A  50
THR A  46
GLY A 144
ASP A 142
 None
None
None
None
ZN  A 501 ( 4.8A)
 1.19A 3sfuC-1cg2A:
undetectable		 3sfuC-1cg2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ib1 14-3-3 ZETA ISOFORM

(Homo sapiens) 		PF00244
(14-3-3) 		5 ARG A  56
LEU A  90
LEU A  98
GLY A 123
ASP A 124
 TPO  E  31 ( 3.0A)
None
None
None
None
 1.32A 3sfuC-1ib1A:
undetectable		 3sfuC-1ib1A:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		6 ASP A 255
LEU A 306
THR A 313
ASN A 317
GLY A 353
ASP A 354
 None
None
None
None
None
MN  A 601 ( 2.3A)
 0.82A 3sfuC-1khwA:
37.3		 3sfuC-1khwA:
32.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		6 ASP A 255
SER A 308
THR A 313
ASN A 317
GLY A 353
ASP A 354
 None
None
None
None
None
MN  A 601 ( 2.3A)
 0.77A 3sfuC-1khwA:
37.3		 3sfuC-1khwA:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		5 LEU A 130
THR B 166
ASN B 139
GLY B 140
ASP A 104
 None
 1.23A 3sfuC-1poiA:
undetectable		 3sfuC-1poiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		5 LEU A 240
ASP A 226
ASN A 228
GLY A 231
ASP A 232
 None
 1.45A 3sfuC-1qguA:
undetectable		 3sfuC-1qguA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4w GLUTATHIONE
S-TRANSFERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF01323
(DSBA) 		5 LEU A 103
ASP A  13
LEU A 183
THR A 172
GLY A  46
 None
 1.41A 3sfuC-1r4wA:
undetectable		 3sfuC-1r4wA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1raj GENOME POLYPROTEIN

(Enterovirus C) 		PF00680
(RdRP_1) 		5 ASP A 238
THR A 293
ASN A 297
GLY A 327
ASP A 328
 None
 0.69A 3sfuC-1rajA:
6.2		 3sfuC-1rajA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN

(Rhinovirus B) 		PF00073
(Rhv) 		5 LEU 1 146
SER 1 144
THR 1 237
THR 1 236
ASN 1  84
 None
 1.30A 3sfuC-1rhi1:
undetectable		 3sfuC-1rhi1:
19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		6 ASP A 247
LEU A 298
THR A 305
ASN A 309
GLY A 342
ASP A 343
 None
 0.73A 3sfuC-1sh2A:
49.1		 3sfuC-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		6 LEU A 298
SER A 300
THR A 305
ASN A 309
GLY A 342
ASP A 343
 None
 0.89A 3sfuC-1sh2A:
49.1		 3sfuC-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		8 LYS A 166
ARG A 182
LEU A 184
ASP A 247
LEU A 298
ASN A 309
GLY A 342
ASP A 343
 None
 0.48A 3sfuC-1sh2A:
49.1		 3sfuC-1sh2A:
57.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		6 LYS A 159
ASP A 239
THR A 292
ASN A 296
GLY A 326
ASP A 327
 None
 0.77A 3sfuC-1tp7A:
30.8		 3sfuC-1tp7A:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		5 ARG A 270
ASP A 329
LEU A 391
THR A 398
ASP A 453
 None
 1.11A 3sfuC-1wacA:
15.1		 3sfuC-1wacA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1

(Solanum
lycopersicum) 		PF01095
(Pectinesterase) 		5 LEU A 113
THR A  66
THR A  65
GLY A  61
ASP A  96
 None
 1.45A 3sfuC-1xg2A:
undetectable		 3sfuC-1xg2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		5 ASP A 238
SER A 287
ASN A 296
GLY A 326
ASP A 327
 None
None
None
None
SM  A 901 (-2.6A)
 1.12A 3sfuC-1xr5A:
30.8		 3sfuC-1xr5A:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		5 ARG A 174
ASP A 239
ASN A 296
GLY A 326
ASP A 327
 None
 0.87A 3sfuC-1xr6A:
30.9		 3sfuC-1xr6A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		5 ARG A 174
ASP A 239
THR A 292
GLY A 326
ASP A 327
 None
 0.92A 3sfuC-1xr6A:
30.9		 3sfuC-1xr6A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c63 14-3-3 PROTEIN ETA

(Homo sapiens) 		PF00244
(14-3-3) 		5 ARG A  57
LEU A  93
LEU A 101
GLY A 128
ASP A 129
 None
 1.32A 3sfuC-2c63A:
undetectable		 3sfuC-2c63A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 ASP A 350
SER A 405
ASN A 414
GLY A 447
ASP A 448
 None
 1.13A 3sfuC-2cjqA:
23.8		 3sfuC-2cjqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		5 ASP A 245
THR A 303
ASN A 307
GLY A 337
ASP A 338
 None
 0.92A 3sfuC-2d7sA:
32.2		 3sfuC-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		6 LYS A 164
ARG A 179
ASP A 245
ASN A 307
GLY A 337
ASP A 338
 None
 0.80A 3sfuC-2d7sA:
32.2		 3sfuC-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		5 LYS A 164
ASP A 245
THR A 303
ASN A 307
ASP A 338
 None
 1.39A 3sfuC-2d7sA:
32.2		 3sfuC-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgj HYPOTHETICAL PROTEIN
EBHA

(Staphylococcus
aureus) 		PF01468
(GA) 		5 ARG A  23
ASP A  24
LEU A  77
GLY A 114
ASP A 113
 None
None
None
SO4  A2002 ( 3.8A)
None
 1.25A 3sfuC-2dgjA:
undetectable		 3sfuC-2dgjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5e HYPOTHETICAL PROTEIN
MM_2497

(Methanosarcina
mazei) 		PF01983
(CofC) 		5 ASP A  94
LEU A  95
THR A 123
ASN A 124
GLY A 118
 None
None
None
None
TRS  A 302 ( 4.5A)
 1.23A 3sfuC-2i5eA:
undetectable		 3sfuC-2i5eA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		6 LYS 1 342
ARG 1 357
ASP 1 421
ASN 1 480
GLY 1 510
ASP 1 511
 None
 0.87A 3sfuC-2ijd1:
31.0		 3sfuC-2ijd1:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		5 LYS 1 342
ASP 1 421
THR 1 476
GLY 1 510
ASP 1 511
 None
 0.89A 3sfuC-2ijd1:
31.0		 3sfuC-2ijd1:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K

(Homo sapiens) 		PF00481
(PP2C) 		5 ASP A 109
SER A  99
THR A 327
GLY A 299
ASP A 337
 MG  A   1 ( 4.9A)
None
None
None
MG  A   1 (-3.1A)
 1.41A 3sfuC-2iq1A:
undetectable		 3sfuC-2iq1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ARG A 242
LEU A 245
ASP A 103
SER A  58
GLY A 100
 None
 0.97A 3sfuC-2isaA:
undetectable		 3sfuC-2isaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npm 14-3-3 DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		5 ARG A  84
LEU A 120
LEU A 128
GLY A 153
ASP A 154
 None
 1.38A 3sfuC-2npmA:
undetectable		 3sfuC-2npmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhp FRUCTOKINASE

(Bacteroides
thetaiotaomicron) 		PF00294
(PfkB) 		5 LEU A 154
ASP A 151
THR A 214
GLY A 245
ASP A 246
 None
 1.28A 3sfuC-2qhpA:
undetectable		 3sfuC-2qhpA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyy N-PAC PROTEIN

(Homo sapiens) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 LEU A 277
SER A 280
ASN A 285
GLY A 397
ASP A 396
 NA7  A1555 (-3.2A)
None
None
K  A1554 (-4.3A)
None
 1.26A 3sfuC-2uyyA:
undetectable		 3sfuC-2uyyA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9x PUTATIVE ACETYL
XYLAN ESTERASE

(Cellvibrio
japonicus) 		PF00657
(Lipase_GDSL) 		5 SER A 160
THR A 173
THR A 174
ASN A 158
GLY A 155
 None
None
GOL  A1364 (-3.6A)
None
None
 1.24A 3sfuC-2w9xA:
undetectable		 3sfuC-2w9xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 LEU A 676
LEU A 562
THR A 650
GLY A 545
ASP A 588
 None
 1.44A 3sfuC-2wyhA:
undetectable		 3sfuC-2wyhA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 244
THR A 219
THR A 202
ASN A 203
GLY A 204
 None
 1.14A 3sfuC-2xe4A:
undetectable		 3sfuC-2xe4A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 646
SER A 653
THR A 660
GLY A 642
ASP A 644
 None
 1.31A 3sfuC-2xf2A:
undetectable		 3sfuC-2xf2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp6 THIOREDOXIN FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00578
(AhpC-TSA) 		5 ASP A  51
LEU A  64
SER A  65
GLY A 162
ASP A  48
 None
 1.19A 3sfuC-2yp6A:
undetectable		 3sfuC-2yp6A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy 14-3-3-LIKE PROTEIN
GF14-C

(Oryza sativa) 		PF00244
(14-3-3) 		5 ARG C  58
LEU C  94
LEU C 102
GLY C 127
ASP C 128
 None
 1.45A 3sfuC-3axyC:
undetectable		 3sfuC-3axyC:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brx ANNEXIN

(Gossypium
hirsutum) 		PF00191
(Annexin) 		5 LEU A  66
THR A  34
ASN A  35
GLY A  37
ASP A  41
 None
CA  A 327 ( 4.9A)
None
None
None
 1.45A 3sfuC-3brxA:
undetectable		 3sfuC-3brxA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE

(Xanthomonas
campestris) 		PF08450
(SGL) 		5 LEU A 130
THR A  88
ASN A  89
GLY A  90
ASP A 135
 None
None
CA  A 707 ( 4.3A)
None
CA  A 705 ( 4.8A)
 1.26A 3sfuC-3dr2A:
undetectable		 3sfuC-3dr2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		5 LEU A 108
ASP A 105
LEU A 137
GLY A 212
ASP A 213
 None
SO4  A 281 ( 4.5A)
None
SO4  A 281 (-3.4A)
None
 1.44A 3sfuC-3h74A:
undetectable		 3sfuC-3h74A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		5 ASP A 238
SER A 289
ASN A 298
GLY A 328
ASP A 329
 BUP  A 464 (-3.2A)
BUP  A 464 (-3.0A)
None
None
BUP  A 464 ( 4.1A)
 1.04A 3sfuC-3n6nA:
30.6		 3sfuC-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		6 LYS A 159
ARG A 174
ASP A 238
ASN A 298
GLY A 328
ASP A 329
 BUP  A 464 (-3.8A)
BUP  A 464 (-3.8A)
BUP  A 464 (-3.2A)
None
None
BUP  A 464 ( 4.1A)
 0.63A 3sfuC-3n6nA:
30.6		 3sfuC-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		6 LYS A 159
ARG A 174
ASP A 238
THR A 294
GLY A 328
ASP A 329
 BUP  A 464 (-3.8A)
BUP  A 464 (-3.8A)
BUP  A 464 (-3.2A)
None
None
BUP  A 464 ( 4.1A)
 0.64A 3sfuC-3n6nA:
30.6		 3sfuC-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		5 THR A 202
THR A 200
ASN A 156
GLY A 198
ASP A 149
 None
 1.42A 3sfuC-3sqlA:
undetectable		 3sfuC-3sqlA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubw 14-3-3 PROTEIN
EPSILON

(Homo sapiens) 		PF00244
(14-3-3) 		5 ARG A  57
LEU A  93
LEU A 101
GLY A 126
ASP A 127
 None
None
CSO  A  98 ( 4.7A)
None
None
 1.28A 3sfuC-3ubwA:
undetectable		 3sfuC-3ubwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		5 ARG A 246
LEU A 115
THR A 161
ASN A 253
GLY A 158
 PGE  A 505 (-3.2A)
None
None
TAU  A 501 (-3.1A)
TAU  A 501 ( 4.3A)
 1.12A 3sfuC-3v39A:
undetectable		 3sfuC-3v39A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 ARG A 456
LEU A 358
LEU A  45
GLY A  49
ASP A  48
 None
 1.40A 3sfuC-3wy2A:
undetectable		 3sfuC-3wy2A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 ASP A  68
SER A  63
THR A 120
ASN A 121
GLY A 119
 None
 1.35A 3sfuC-4dvjA:
undetectable		 3sfuC-4dvjA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx0 14-3-3-LIKE PROTEIN
E

(Nicotiana
tabacum) 		PF00244
(14-3-3) 		5 ARG A  61
LEU A  97
LEU A 105
GLY A 130
ASP A 131
 None
 1.45A 3sfuC-4dx0A:
undetectable		 3sfuC-4dx0A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 211
ASP A 145
LEU A 189
THR A 185
GLY A 184
 None
 1.44A 3sfuC-4e3cA:
undetectable		 3sfuC-4e3cA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 LEU A 359
ASP A 246
THR A 311
GLY A 248
ASP A 247
 None
 1.31A 3sfuC-4fffA:
undetectable		 3sfuC-4fffA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0s BASIC PHOSPHOLIPASE
A2 HOMOLOG CTS-R6

(Trimeresurus
stejnegeri) 		PF00068
(Phospholip_A2_1) 		5 LEU A 110
ASP A  39
ASN A 117
GLY A  26
ASP A  42
 None
 1.25A 3sfuC-4h0sA:
undetectable		 3sfuC-4h0sA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi0 UREASE ACCESSORY
PROTEIN UREH

(Helicobacter
pylori) 		PF01774
(UreD) 		5 SER B 163
THR B 127
THR B 126
ASN B 125
GLY B 124
 None
 1.36A 3sfuC-4hi0B:
undetectable		 3sfuC-4hi0B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ARG A 474
ASP A 541
ASN A 613
GLY A 667
ASP A 668
 SO4  A1009 (-3.1A)
None
None
None
None
 1.34A 3sfuC-4k6mA:
22.6		 3sfuC-4k6mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 LYS A 459
ARG A 474
ASP A 541
GLY A 667
ASP A 668
 None
SO4  A1009 (-3.1A)
None
None
None
 1.36A 3sfuC-4k6mA:
22.6		 3sfuC-4k6mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtp RNA DEPENDENT RNA
POLYMERASE

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5) 		5 ASP A 541
SER A 604
ASN A 613
GLY A 667
ASP A 668
 ASP  A 541 ( 0.6A)
SER  A 604 ( 0.0A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
ASP  A 668 ( 0.6A)
 1.04A 3sfuC-4mtpA:
19.6		 3sfuC-4mtpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtp RNA DEPENDENT RNA
POLYMERASE

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5) 		5 ASP A 541
SER A 604
THR A 609
ASN A 613
GLY A 667
 ASP  A 541 ( 0.6A)
SER  A 604 ( 0.0A)
THR  A 609 ( 0.8A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
 1.11A 3sfuC-4mtpA:
19.6		 3sfuC-4mtpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n82 RIBONUCLEOTIDE
REDUCTASE

(Streptococcus
sanguinis) 		no annotation 5 LEU B 113
LEU B  61
THR B  80
THR B  81
GLY B  84
 None
 1.16A 3sfuC-4n82B:
undetectable		 3sfuC-4n82B:
16.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		10 LYS A 166
LEU A 184
ASP A 247
LEU A 298
SER A 300
THR A 305
THR A 306
ASN A 309
GLY A 342
ASP A 343
 None
 0.31A 3sfuC-4nruA:
57.7		 3sfuC-4nruA:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		6 ASP A 240
LEU A 291
THR A 298
ASN A 302
GLY A 332
ASP A 333
 None
 0.99A 3sfuC-4nz0A:
32.6		 3sfuC-4nz0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		7 LYS A 159
ARG A 174
ASP A 240
LEU A 291
ASN A 302
GLY A 332
ASP A 333
 None
 0.90A 3sfuC-4nz0A:
32.6		 3sfuC-4nz0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfb C4-DICARBOXYLATE-BIN
DING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		5 LEU A 174
THR A 104
ASN A 101
GLY A  94
ASP A  95
 None
 1.25A 3sfuC-4pfbA:
undetectable		 3sfuC-4pfbA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3j PROTEIN STU2

(Saccharomyces
cerevisiae) 		no annotation 5 ASP C 447
LEU C 449
THR C 494
GLY C 491
ASP C 490
 None
 1.44A 3sfuC-4u3jC:
undetectable		 3sfuC-4u3jC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		5 LEU A 242
ASP A 228
ASN A 230
GLY A 233
ASP A 234
 None
 1.44A 3sfuC-4wzbA:
undetectable		 3sfuC-4wzbA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		5 ASP A 238
SER A 289
THR A 294
GLY A 328
ASP A 329
 None
 0.86A 3sfuC-4zpdA:
31.3		 3sfuC-4zpdA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		6 LYS A 159
ARG A 174
ASP A 238
ASN A 298
GLY A 328
ASP A 329
 None
 1.02A 3sfuC-4zpdA:
31.3		 3sfuC-4zpdA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		6 LYS A 159
ASP A 238
THR A 294
ASN A 298
GLY A 328
ASP A 329
 None
 0.91A 3sfuC-4zpdA:
31.3		 3sfuC-4zpdA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq0 14-3-3 PROTEIN

(Giardia
intestinalis) 		PF00244
(14-3-3) 		5 ARG A  60
LEU A  98
LEU A 106
GLY A 131
ASP A 132
 None
 1.36A 3sfuC-4zq0A:
undetectable		 3sfuC-4zq0A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2w HYPOTHETICAL (DI
HEME) PROTEIN

(Candidatus
Kuenenia
stuttgartiensis) 		PF00034
(Cytochrom_C) 		5 LYS C 131
ASP C 312
THR C 250
GLY C 251
ASP C 290
 HEC  C 404 (-4.2A)
None
HEC  C 405 (-3.1A)
None
None
 1.43A 3sfuC-5c2wC:
undetectable		 3sfuC-5c2wC:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 LYS A 385
LEU A 200
LEU A 207
GLY A 371
ASP A 372
 None
 1.44A 3sfuC-5c3mA:
undetectable		 3sfuC-5c3mA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 ARG B 280
ASP B 374
LEU B 436
THR B 444
ASP B 351
 ATP  B 701 (-2.8A)
None
None
SO4  B 702 (-3.4A)
ATP  B 701 (-2.4A)
 1.23A 3sfuC-5cyrB:
15.8		 3sfuC-5cyrB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 ARG B 280
ASP B 374
THR B 444
GLY B 350
ASP B 351
 ATP  B 701 (-2.8A)
None
SO4  B 702 (-3.4A)
None
ATP  B 701 (-2.4A)
 1.19A 3sfuC-5cyrB:
15.8		 3sfuC-5cyrB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		5 LEU A 150
SER A  53
THR A 170
THR A 169
GLY A 162
 None
 1.23A 3sfuC-5e3cA:
undetectable		 3sfuC-5e3cA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 SER A 150
THR A 166
THR A 164
ASN A 168
GLY A 163
 None
LEU  A 602 ( 3.0A)
LEU  A 602 (-4.7A)
None
None
 1.36A 3sfuC-5ecoA:
undetectable		 3sfuC-5ecoA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		5 LEU A 535
SER A 536
ASN A 367
GLY A 366
ASP A 348
 None
 1.37A 3sfuC-5hp6A:
undetectable		 3sfuC-5hp6A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq6 RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 ASP A 538
SER A 600
ASN A 609
GLY A 662
ASP A 663
 None
 1.16A 3sfuC-5iq6A:
19.6		 3sfuC-5iq6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqp 14-3-3 PROTEIN THETA

(Homo sapiens) 		PF00244
(14-3-3) 		5 ARG A  56
LEU A  90
LEU A  98
GLY A 123
ASP A 124
 SO4  A 301 (-3.0A)
None
None
None
None
 1.31A 3sfuC-5iqpA:
undetectable		 3sfuC-5iqpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6f 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE
SYNTHASE, CHORISMATE
MUTASE-ISOZYME 3

(Geobacillus sp.
GHH01) 		PF00793
(DAHP_synth_1)
PF01817
(CM_2) 		5 LEU A  57
SER A  59
THR A  68
GLY A  64
ASP A  63
 None
 1.44A 3sfuC-5j6fA:
undetectable		 3sfuC-5j6fA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ASP A 538
SER A 600
ASN A 609
GLY A 662
ASP A 663
 None
 1.28A 3sfuC-5jjrA:
20.9		 3sfuC-5jjrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		5 LEU A 410
THR A 446
THR A 447
ASN A 420
ASP A 421
 None
 1.38A 3sfuC-5k04A:
undetectable		 3sfuC-5k04A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 ASP A 539
THR A 606
ASN A 610
GLY A 662
ASP A 663
 None
 1.17A 3sfuC-5k5mA:
20.3		 3sfuC-5k5mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu2 14-3-3 PROTEIN SIGMA

(Homo sapiens) 		PF00244
(14-3-3) 		5 ARG A  56
LEU A  92
LEU A 100
GLY A 125
ASP A 126
 None
 1.43A 3sfuC-5lu2A:
undetectable		 3sfuC-5lu2A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bacteroides
thetaiotaomicron) 		PF07944
(Glyco_hydro_127) 		5 THR A 475
THR A  39
ASN A  38
GLY A  24
ASP A  27
 None
 1.43A 3sfuC-5mqoA:
undetectable		 3sfuC-5mqoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6n PROTEIN BMH1

(Saccharomyces
cerevisiae) 		no annotation 5 ARG A  58
LEU A  95
LEU A 103
GLY A 128
ASP A 129
 None
 1.29A 3sfuC-5n6nA:
undetectable		 3sfuC-5n6nA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngj TAIL TUBE PROTEIN

(Escherichia
virus T5) 		no annotation 5 ASP A 374
THR A 360
THR A 361
ASN A 364
GLY A 371
 None
 0.99A 3sfuC-5ngjA:
undetectable		 3sfuC-5ngjA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngj TAIL TUBE PROTEIN

(Escherichia
virus T5) 		no annotation 5 THR A 360
THR A 361
ASN A 364
GLY A 371
ASP A 370
 None
 1.41A 3sfuC-5ngjA:
undetectable		 3sfuC-5ngjA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		6 LYS A 458
ARG A 473
ASP A 540
ASN A 612
GLY A 664
ASP A 665
 None
SO4  A1004 (-3.0A)
None
None
None
None
 1.30A 3sfuC-5tmhA:
19.9		 3sfuC-5tmhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f DNA REPLICATION
LICENSING FACTOR
MCM7

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 LEU 7 590
SER 7 592
THR 7 685
THR 7 688
GLY 7 691
 None
AGS  72001 ( 4.9A)
None
None
None
 1.45A 3sfuC-5v8f7:
undetectable		 3sfuC-5v8f7:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 ASP A 477
SER A 489
THR A 262
GLY A 333
ASP A 342
 None
None
None
None
MN  A 602 (-2.6A)
 1.32A 3sfuC-5x49A:
undetectable		 3sfuC-5x49A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		6 LYS A 155
ARG A 170
ASP A 234
ASN A 293
GLY A 323
ASP A 324
 GTP  A 501 (-4.8A)
GTP  A 501 (-3.7A)
GTP  A 501 (-2.6A)
None
None
GTP  A 501 ( 4.2A)
 0.87A 3sfuC-5xe0A:
31.4		 3sfuC-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		5 LYS A 155
ASP A 234
THR A 289
GLY A 323
ASP A 324
 GTP  A 501 (-4.8A)
GTP  A 501 (-2.6A)
None
None
GTP  A 501 ( 4.2A)
 0.87A 3sfuC-5xe0A:
31.4		 3sfuC-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
1

(Saccharomyces
cerevisiae) 		no annotation 5 ARG A 191
ASP A 195
LEU A 150
ASN A 199
ASP A 198
 None
 1.45A 3sfuC-5y58A:
undetectable		 3sfuC-5y58A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 ASP A 350
SER A 405
ASN A 414
GLY A 447
ASP A 448
 GOL  A 732 (-4.1A)
GOL  A 732 ( 4.7A)
None
None
None
 1.09A 3sfuC-5y6rA:
24.5		 3sfuC-5y6rA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 LYS A 263
ASP A 350
ASN A 414
GLY A 447
ASP A 448
 None
GOL  A 732 (-4.1A)
None
None
None
 1.02A 3sfuC-5y6rA:
24.5		 3sfuC-5y6rA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 5 LYS A 580
ASP A 588
LEU A 504
THR A 502
GLY A 500
 None
 1.41A 3sfuC-5yp3A:
undetectable		 3sfuC-5yp3A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byk 14-3-3 PROTEIN
BETA/ALPHA

(Homo sapiens) 		no annotation 5 ARG A  58
LEU A  92
LEU A 100
GLY A 125
ASP A 126
 None
 1.32A 3sfuC-6bykA:
undetectable		 3sfuC-6bykA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eih 14-3-3 PROTEIN
EPSILON

(Homo sapiens) 		no annotation 5 ARG A  57
LEU A  93
LEU A 101
GLY A 126
ASP A 127
 None
 1.27A 3sfuC-6eihA:
undetectable		 3sfuC-6eihA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A1320
LEU A1300
THR A1316
GLY A1297
ASP A1277
 None
 1.14A 3sfuC-6f42A:
undetectable		 3sfuC-6f42A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fel 14-3-3 PROTEIN GAMMA

(Homo sapiens) 		no annotation 5 ARG A  57
LEU A  93
LEU A 101
GLY A 128
ASP A 129
 None
 1.30A 3sfuC-6felA:
undetectable		 3sfuC-6felA:
9.58