SIMILAR PATTERNS OF AMINO ACIDS FOR 3SFU_B_RBVB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 THR A 234
ASN A 235
TYR A 293
GLY A 262
LEU A 270
 None
GLC  A 501 (-3.8A)
None
None
None
 1.40A 3sfuB-1bdgA:
undetectable		 3sfuB-1bdgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxz GLYCININ G1

(Glycine max) 		PF00190
(Cupin_1) 		5 THR A  66
ASN A  67
GLY A  68
ASP A 148
LEU A 338
 None
 1.37A 3sfuB-1fxzA:
undetectable		 3sfuB-1fxzA:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		7 ASP A 255
ASN A 317
TYR A 352
GLY A 353
ASP A 354
ASP A 355
LEU A 402
 None
None
None
None
MN  A 601 ( 2.3A)
MN  A 601 (-4.0A)
None
 0.42A 3sfuB-1khwA:
37.5		 3sfuB-1khwA:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		5 ASN A  74
TYR A 334
GLY A 333
ASP A  76
LEU A 323
 None
 1.46A 3sfuB-1oa1A:
undetectable		 3sfuB-1oa1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI ALPHA
SUBUNIT) (LIGHT
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		5 ASP L   9
THR L  89
TYR L  91
GLY L 107
LEU H  45
 None
 1.40A 3sfuB-1qfwL:
undetectable		 3sfuB-1qfwL:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1raj GENOME POLYPROTEIN

(Enterovirus C) 		PF00680
(RdRP_1) 		7 ASP A 238
ASN A 297
TYR A 326
GLY A 327
ASP A 328
ASP A 329
LEU A 374
 None
 0.66A 3sfuB-1rajA:
19.6		 3sfuB-1rajA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		7 ASP A 238
ASN A 297
TYR A 326
GLY A 327
ASP A 328
ASP A 329
LEU A 374
 None
None
None
None
None
CA  A 501 (-3.4A)
None
 0.66A 3sfuB-1rdrA:
23.3		 3sfuB-1rdrA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 ASP A 350
ASN A 414
GLY A 447
ASP A 448
ASP A 449
 None
 0.91A 3sfuB-1s4fA:
27.5		 3sfuB-1s4fA:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		7 ASP A 247
ASN A 309
GLY A 342
ASP A 343
ASP A 344
LEU A 391
ARG A 392
 None
 0.79A 3sfuB-1sh2A:
49.7		 3sfuB-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		7 ASP A 247
ASN A 309
TYR A 341
GLY A 342
ASP A 343
ASP A 344
LEU A 391
 None
 0.43A 3sfuB-1sh2A:
49.7		 3sfuB-1sh2A:
57.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		7 ASP A 239
ASN A 296
TYR A 325
GLY A 326
ASP A 327
ASP A 328
LEU A 373
 None
 0.56A 3sfuB-1tp7A:
25.7		 3sfuB-1tp7A:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		7 ASP A 238
ASN A 296
TYR A 325
GLY A 326
ASP A 327
ASP A 328
LEU A 373
 None
None
None
None
SM  A 901 (-2.6A)
SM  A 901 (-3.0A)
None
 0.75A 3sfuB-1xr5A:
30.9		 3sfuB-1xr5A:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		7 ASP A 239
ASN A 296
TYR A 325
GLY A 326
ASP A 327
ASP A 328
LEU A 373
 None
 0.59A 3sfuB-1xr6A:
30.9		 3sfuB-1xr6A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xup GLYCEROL KINASE

(Enterococcus
casseliflavus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ASP O 167
THR O  81
ASN O  82
GLY O 245
LEU O 251
 None
 1.48A 3sfuB-1xupO:
undetectable		 3sfuB-1xupO:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		5 ASP A 930
ASN A 927
GLY A 924
ASP A 926
LEU A 861
 None
 1.36A 3sfuB-2aqxA:
undetectable		 3sfuB-2aqxA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 ASP A 350
ASN A 414
GLY A 447
ASP A 448
ASP A 449
 None
 0.94A 3sfuB-2cjqA:
24.3		 3sfuB-2cjqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		7 ASP A 245
ASN A 307
TYR A 336
GLY A 337
ASP A 338
ASP A 339
LEU A 386
 None
 0.63A 3sfuB-2d7sA:
32.1		 3sfuB-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE
VPG1 PROTEIN

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1)
no annotation 		5 THR A 308
ASN A 307
GLY A 337
LEU A 386
ARG B1011
 None
 1.14A 3sfuB-2d7sA:
32.1		 3sfuB-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfj DIADENOSINETETRAPHOS
PHATASE

(Shigella
flexneri) 		PF00149
(Metallophos) 		5 ASP A  37
THR A 181
ASN A  65
ASP A  67
LEU A 143
 MN  A1001 ( 3.0A)
None
MN  A1001 (-2.6A)
None
None
 1.48A 3sfuB-2dfjA:
undetectable		 3sfuB-2dfjA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwu GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 THR A 242
ASN A  41
GLY A  39
ASP A  14
LEU A  65
 None
None
None
DGL  A 278 (-3.6A)
None
 1.41A 3sfuB-2dwuA:
undetectable		 3sfuB-2dwuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		5 THR A 412
ASN A 411
GLY A 405
ASP A 406
LEU A  78
 None
 1.49A 3sfuB-2eaeA:
undetectable		 3sfuB-2eaeA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)

(West Nile virus) 		PF00972
(Flavi_NS5) 		5 ASP A 541
ASN A 613
GLY A 667
ASP A 668
ASP A 669
 None
 0.77A 3sfuB-2hcsA:
16.9		 3sfuB-2hcsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igi OLIGORIBONUCLEASE

(Escherichia
coli) 		PF00929
(RNase_T) 		5 ASP A  58
THR A  15
ASN A  61
GLY A  16
ASP A  18
 None
 1.28A 3sfuB-2igiA:
undetectable		 3sfuB-2igiA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		7 ASP 1 421
ASN 1 480
TYR 1 509
GLY 1 510
ASP 1 511
ASP 1 512
LEU 1 557
 None
 0.59A 3sfuB-2ijd1:
31.1		 3sfuB-2ijd1:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		6 ASP A 247
ASN A 309
TYR A 345
GLY A 346
ASP A 348
LEU A 387
 None
 0.70A 3sfuB-2uutA:
38.9		 3sfuB-2uutA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 THR A1272
ASN A1273
GLY A1274
ASP A1442
ASP A1322
 None
MPD  A1695 (-4.4A)
MPD  A1695 ( 3.2A)
MN  A   4 (-2.3A)
None
 1.47A 3sfuB-2zxqA:
undetectable		 3sfuB-2zxqA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		7 ASP A 238
ASN A 298
TYR A 327
GLY A 328
ASP A 329
ASP A 330
LEU A 375
 BUP  A 464 (-3.2A)
None
None
None
BUP  A 464 ( 4.1A)
None
None
 0.53A 3sfuB-3n6nA:
30.5		 3sfuB-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Entamoeba
histolytica) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ASP A  31
THR A  28
ASN A  29
GLY A  71
LEU A 117
 None
 1.33A 3sfuB-3p91A:
undetectable		 3sfuB-3p91A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr8 OLIGORIBONUCLEASE

(Coxiella
burnetii) 		PF00929
(RNase_T) 		5 ASP A  59
THR A  16
ASN A  62
GLY A  17
ASP A  19
 None
 1.33A 3sfuB-3tr8A:
undetectable		 3sfuB-3tr8A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus) 		PF01670
(Glyco_hydro_12) 		5 ASN A 132
TYR A 130
GLY A 131
ASP A 284
LEU A 310
 CA  A 402 (-3.2A)
None
None
None
None
 1.48A 3sfuB-3wq1A:
undetectable		 3sfuB-3wq1A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b61 ALGINATE PRODUCTION
PROTEIN ALGE

(Pseudomonas
aeruginosa) 		PF13372
(Alginate_exp) 		5 ASP A 102
THR A 163
ASN A 164
LEU A 197
ARG A 119
 None
 1.33A 3sfuB-4b61A:
undetectable		 3sfuB-4b61A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 THR A 350
ASN A 349
GLY A 318
ASP A 321
LEU A 369
 None
 1.50A 3sfuB-4bf5A:
undetectable		 3sfuB-4bf5A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c18 TSI2

(Pseudomonas
aeruginosa) 		no annotation 5 ASP A  49
TYR A  44
GLY A  43
ASP A  45
LEU A  22
 None
 1.31A 3sfuB-4c18A:
undetectable		 3sfuB-4c18A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ASP A 541
ASN A 613
GLY A 667
ASP A 668
ASP A 669
 None
 0.86A 3sfuB-4k6mA:
24.6		 3sfuB-4k6mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtp RNA DEPENDENT RNA
POLYMERASE

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5) 		5 ASP A 541
ASN A 613
GLY A 667
ASP A 668
ASP A 669
 ASP  A 541 ( 0.6A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
ASP  A 668 ( 0.6A)
ASP  A 669 ( 0.6A)
 1.01A 3sfuB-4mtpA:
21.6		 3sfuB-4mtpA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		8 ASP A 247
THR A 306
ASN A 309
TYR A 341
GLY A 342
ASP A 343
ASP A 344
LEU A 391
 None
None
None
2NG  A1101 ( 4.8A)
None
None
MG  A1102 (-3.4A)
2NG  A1101 ( 4.1A)
 0.27A 3sfuB-4nruA:
56.7		 3sfuB-4nruA:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		7 ASP A 240
ASN A 302
TYR A 331
GLY A 332
ASP A 333
ASP A 334
LEU A 380
 None
 0.63A 3sfuB-4nz0A:
32.4		 3sfuB-4nz0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		7 ASP A 238
ASN A 298
TYR A 327
GLY A 328
ASP A 329
ASP A 330
LEU A 375
 None
 0.61A 3sfuB-4zpdA:
31.4		 3sfuB-4zpdA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ax7 PYRUVYL TRANSFERASE
1

(Schizosaccharomyces
pombe) 		PF04230
(PS_pyruv_trans) 		5 ASN A 160
GLY A 158
ASP A 106
LEU A 338
ARG A 337
 None
 1.42A 3sfuB-5ax7A:
undetectable		 3sfuB-5ax7A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cy4 OLIGORIBONUCLEASE

(Acinetobacter
baumannii) 		PF00929
(RNase_T) 		5 ASP A  60
THR A  17
ASN A  63
GLY A  18
ASP A  20
 None
 1.39A 3sfuB-5cy4A:
undetectable		 3sfuB-5cy4A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 7 ASP B 374
THR B 444
TYR B 349
GLY B 350
ASP B 351
ASP B 352
LEU B 513
 None
SO4  B 702 (-3.4A)
None
None
ATP  B 701 (-2.4A)
ATP  B 701 (-3.5A)
None
 0.77A 3sfuB-5cyrB:
8.9		 3sfuB-5cyrB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 THR B 448
TYR B 349
ASP B 351
ASP B 352
LEU B 513
 None
None
ATP  B 701 (-2.4A)
ATP  B 701 (-3.5A)
None
 1.41A 3sfuB-5cyrB:
8.9		 3sfuB-5cyrB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 5 ASP B 266
GLY B 358
ASP B 359
ASP B 360
LEU B 399
 None
 0.25A 3sfuB-5i61B:
22.3		 3sfuB-5i61B:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 5 THR B 332
GLY B 358
ASP B 359
ASP B 360
LEU B 399
 None
 1.31A 3sfuB-5i61B:
22.3		 3sfuB-5i61B:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq6 RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 ASP A 538
ASN A 609
GLY A 662
ASP A 663
ASP A 664
 None
 0.79A 3sfuB-5iq6A:
21.3		 3sfuB-5iq6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		5 ASP A 539
ASN A 610
GLY A 662
ASP A 663
ASP A 664
 None
 1.00A 3sfuB-5k5mA:
21.1		 3sfuB-5k5mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		5 THR A 169
ASN A 211
GLY A 163
ASP A 164
ASP A 161
 None
 1.33A 3sfuB-5odrA:
undetectable		 3sfuB-5odrA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ASP A 540
ASN A 612
GLY A 664
ASP A 665
ASP A 666
 None
 0.95A 3sfuB-5tmhA:
22.3		 3sfuB-5tmhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v96 S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE

(Naegleria
fowleri) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A 200
GLY A 137
ASP A 139
LEU A 386
ARG A 385
 NAD  A 501 (-3.6A)
PO4  A 503 ( 4.5A)
EDO  A 512 (-3.3A)
NAD  A 501 (-3.9A)
EDO  A 509 (-3.6A)
 1.32A 3sfuB-5v96A:
undetectable		 3sfuB-5v96A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6x MRNA CAPPING ENZYME
P5

(Rice dwarf
virus) 		no annotation 5 ASN C 507
TYR C 565
GLY C 568
ASP C 566
LEU C 797
 None
 1.43A 3sfuB-5x6xC:
undetectable		 3sfuB-5x6xC:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		7 ASP A 234
ASN A 293
TYR A 322
GLY A 323
ASP A 324
ASP A 325
LEU A 370
 GTP  A 501 (-2.6A)
None
None
None
GTP  A 501 ( 4.2A)
None
None
 0.63A 3sfuB-5xe0A:
31.3		 3sfuB-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 ASP A 350
ASN A 414
GLY A 447
ASP A 448
ASP A 449
 GOL  A 732 (-4.1A)
None
None
None
None
 0.86A 3sfuB-5y6rA:
23.9		 3sfuB-5y6rA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE

(Pseudomonas
aeruginosa) 		no annotation 5 ASP A 414
THR A 282
TYR A 286
GLY A 285
LEU A 270
 None
 1.25A 3sfuB-5ykdA:
undetectable		 3sfuB-5ykdA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 5 THR B 193
ASN B 197
GLY B 389
ASP B 388
LEU B  41
 None
 0.95A 3sfuB-6f3mB:
undetectable		 3sfuB-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 5 THR B 193
ASN B 197
GLY B 389
ASP B 388
LEU B 396
 None
 1.37A 3sfuB-6f3mB:
undetectable		 3sfuB-6f3mB:
undetectable