SIMILAR PATTERNS OF AMINO ACIDS FOR 3SFU_A_RBVA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aol GP70

(Murine leukemia
virus) 		PF00429
(TLV_coat) 		5 THR A  24
THR A  18
ASN A  19
TYR A 206
GLY A  20
 None
 1.27A 3sfuA-1aolA:
undetectable		 3sfuA-1aolA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5c RAB6 GTPASE

(Plasmodium
falciparum) 		PF00071
(Ras) 		5 THR A 103
THR A 102
ASN A 101
TYR A  91
ASP A  92
 None
 1.05A 3sfuA-1d5cA:
undetectable		 3sfuA-1d5cA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		5 ASP A 121
SER A 120
GLY A  36
ASP A  32
ASP A  33
 None
None
NAG  A1117 (-3.2A)
None
None
 1.38A 3sfuA-1gxsA:
undetectable		 3sfuA-1gxsA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyn CHLOROPLASTIC
ASCORBATE PEROXIDASE

(Nicotiana
tabacum) 		PF00141
(peroxidase) 		5 ASP A 209
SER A 205
THR A 164
ASP A 215
ASP A 217
 None
None
NA  A 297 (-3.2A)
None
None
 1.32A 3sfuA-1iynA:
undetectable		 3sfuA-1iynA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j71 ASPARTIC PROTEINASE

(Candida
tropicalis) 		PF00026
(Asp) 		5 SER A  89
THR A 117
THR A 116
GLY A  92
ASP A  79
 None
 1.49A 3sfuA-1j71A:
undetectable		 3sfuA-1j71A:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		7 ASP A 255
SER A 308
ASN A 317
TYR A 352
GLY A 353
ASP A 354
ASP A 355
 None
None
None
None
None
MN  A 601 ( 2.3A)
MN  A 601 (-4.0A)
 0.70A 3sfuA-1khwA:
37.1		 3sfuA-1khwA:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 SER A 105
THR A 109
ASN A 110
GLY A 114
ASP A 116
 None
 1.46A 3sfuA-1lbkA:
undetectable		 3sfuA-1lbkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg5 ALCOHOL
DEHYDROGENASE

(Drosophila
melanogaster) 		PF00106
(adh_short) 		5 THR A 116
THR A 115
ASN A 114
TYR A  63
ASP A  64
 None
None
None
None
NAI  A 850 (-3.4A)
 1.45A 3sfuA-1mg5A:
undetectable		 3sfuA-1mg5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qho ALPHA-AMYLASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 THR A 154
TYR A 167
GLY A 157
ASP A 161
ASP A 162
 None
 1.36A 3sfuA-1qhoA:
undetectable		 3sfuA-1qhoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1raj GENOME POLYPROTEIN

(Enterovirus C) 		PF00680
(RdRP_1) 		6 ASP A 238
ASN A 297
TYR A 326
GLY A 327
ASP A 328
ASP A 329
 None
 0.66A 3sfuA-1rajA:
14.4		 3sfuA-1rajA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1raj GENOME POLYPROTEIN

(Enterovirus C) 		PF00680
(RdRP_1) 		6 ASP A 238
THR A 293
TYR A 326
GLY A 327
ASP A 328
ASP A 329
 None
 0.54A 3sfuA-1rajA:
14.4		 3sfuA-1rajA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		6 ASP A 238
ASN A 297
TYR A 326
GLY A 327
ASP A 328
ASP A 329
 None
None
None
None
None
CA  A 501 (-3.4A)
 0.68A 3sfuA-1rdrA:
22.8		 3sfuA-1rdrA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		6 ASP A 238
THR A 293
TYR A 326
GLY A 327
ASP A 328
ASP A 329
 None
None
None
None
None
CA  A 501 (-3.4A)
 0.74A 3sfuA-1rdrA:
22.8		 3sfuA-1rdrA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 ASP A 350
ASN A 414
GLY A 447
ASP A 448
ASP A 449
 None
 0.95A 3sfuA-1s4fA:
27.7		 3sfuA-1s4fA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 ASP A 350
SER A 405
ASN A 414
ASP A 448
ASP A 449
 None
 1.18A 3sfuA-1s4fA:
27.7		 3sfuA-1s4fA:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		7 ASP A 247
SER A 300
ASN A 309
TYR A 341
GLY A 342
ASP A 343
ASP A 344
 None
 0.86A 3sfuA-1sh2A:
49.0		 3sfuA-1sh2A:
57.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		5 SER A 300
THR A 305
TYR A 341
GLY A 342
ASP A 344
 None
 0.84A 3sfuA-1sh2A:
49.0		 3sfuA-1sh2A:
57.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		6 ASP A 239
ASN A 296
TYR A 325
GLY A 326
ASP A 327
ASP A 328
 None
 0.61A 3sfuA-1tp7A:
30.8		 3sfuA-1tp7A:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		6 ASP A 239
THR A 292
TYR A 325
GLY A 326
ASP A 327
ASP A 328
 None
 0.60A 3sfuA-1tp7A:
30.8		 3sfuA-1tp7A:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		5 ASP A 334
SER A 239
THR A 399
TYR A 395
GLY A 396
 None
 1.32A 3sfuA-1ukcA:
undetectable		 3sfuA-1ukcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		6 ASP A 238
ASN A 296
TYR A 325
GLY A 326
ASP A 327
ASP A 328
 None
None
None
None
SM  A 901 (-2.6A)
SM  A 901 (-3.0A)
 0.82A 3sfuA-1xr5A:
30.7		 3sfuA-1xr5A:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		5 ASP A 238
SER A 287
ASN A 296
ASP A 327
ASP A 328
 None
None
None
SM  A 901 (-2.6A)
SM  A 901 (-3.0A)
 1.21A 3sfuA-1xr5A:
30.7		 3sfuA-1xr5A:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		7 ASP A 239
SER A 287
ASN A 296
TYR A 325
GLY A 326
ASP A 327
ASP A 328
 None
 1.11A 3sfuA-1xr6A:
30.9		 3sfuA-1xr6A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 ASP A 350
ASN A 414
GLY A 447
ASP A 448
ASP A 449
 None
 0.97A 3sfuA-2cjqA:
23.9		 3sfuA-2cjqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 ASP A 350
SER A 405
ASN A 414
ASP A 448
ASP A 449
 None
 1.22A 3sfuA-2cjqA:
23.9		 3sfuA-2cjqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE

(Pyrococcus
horikoshii) 		PF00162
(PGK) 		5 THR A  56
ASN A  21
TYR A  66
GLY A  59
ASP A  65
 None
GOL  A 501 (-3.8A)
None
None
None
 1.36A 3sfuA-2cunA:
undetectable		 3sfuA-2cunA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		7 ASP A 245
SER A 298
ASN A 307
TYR A 336
GLY A 337
ASP A 338
ASP A 339
 None
 0.89A 3sfuA-2d7sA:
32.1		 3sfuA-2d7sA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyk GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1) 		5 ASP A 119
SER A 142
THR A 141
THR A 116
GLY A  89
 GDP  A 501 (-2.8A)
GDP  A 501 (-3.4A)
None
None
None
 1.38A 3sfuA-2dykA:
undetectable		 3sfuA-2dykA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcr FLAVODOXIN

(Chondrus
crispus) 		PF00258
(Flavodoxin_1) 		5 SER A   9
THR A   8
THR A  13
ASN A  12
ASP A 148
 FMN  A 174 (-4.4A)
FMN  A 174 (-3.6A)
FMN  A 174 (-3.5A)
FMN  A 174 (-3.5A)
None
 1.49A 3sfuA-2fcrA:
undetectable		 3sfuA-2fcrA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 ASP A 521
SER A 520
ASN A 470
GLY A 444
ASP A 442
 None
 1.30A 3sfuA-2fknA:
undetectable		 3sfuA-2fknA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)

(West Nile virus) 		PF00972
(Flavi_NS5) 		5 ASP A 541
ASN A 613
GLY A 667
ASP A 668
ASP A 669
 None
 0.80A 3sfuA-2hcsA:
16.7		 3sfuA-2hcsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igi OLIGORIBONUCLEASE

(Escherichia
coli) 		PF00929
(RNase_T) 		5 ASP A  58
THR A  15
ASN A  61
GLY A  16
ASP A  18
 None
 1.28A 3sfuA-2igiA:
undetectable		 3sfuA-2igiA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		6 ASP 1 421
ASN 1 480
TYR 1 509
GLY 1 510
ASP 1 511
ASP 1 512
 None
 0.60A 3sfuA-2ijd1:
30.9		 3sfuA-2ijd1:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		5 THR 1 476
TYR 1 509
GLY 1 510
ASP 1 511
ASP 1 512
 None
 0.54A 3sfuA-2ijd1:
30.9		 3sfuA-2ijd1:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K

(Homo sapiens) 		PF00481
(PP2C) 		5 ASP A 109
SER A  99
THR A 327
GLY A 299
ASP A 337
 MG  A   1 ( 4.9A)
None
None
None
MG  A   1 (-3.1A)
 1.40A 3sfuA-2iq1A:
undetectable		 3sfuA-2iq1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		6 ASP A 247
SER A 300
ASN A 309
TYR A 345
GLY A 346
ASP A 348
 None
 1.11A 3sfuA-2uutA:
38.5		 3sfuA-2uutA:
29.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		5 THR A 319
THR A 320
TYR A  17
GLY A 322
ASP A  22
 GOL  A1442 (-4.0A)
GOL  A1442 ( 4.7A)
None
None
None
 1.41A 3sfuA-2w38A:
undetectable		 3sfuA-2w38A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9x PUTATIVE ACETYL
XYLAN ESTERASE

(Cellvibrio
japonicus) 		PF00657
(Lipase_GDSL) 		5 SER A 160
THR A 173
THR A 174
ASN A 158
GLY A 155
 None
None
GOL  A1364 (-3.6A)
None
None
 1.34A 3sfuA-2w9xA:
undetectable		 3sfuA-2w9xA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		5 ASP A 386
SER A 387
THR A 407
GLY A 410
ASP A 376
 None
 1.45A 3sfuA-2yg1A:
undetectable		 3sfuA-2yg1A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ASP A 195
THR A 220
ASN A 268
GLY A 173
ASP A 174
 None
ATP  A 342 (-2.9A)
None
None
None
 1.45A 3sfuA-2z1uA:
undetectable		 3sfuA-2z1uA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 THR A1272
ASN A1273
GLY A1274
ASP A1442
ASP A1322
 None
MPD  A1695 (-4.4A)
MPD  A1695 ( 3.2A)
MN  A   4 (-2.3A)
None
 1.47A 3sfuA-2zxqA:
undetectable		 3sfuA-2zxqA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asi NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		5 ASP A 930
ASN A 913
GLY A 912
ASP A 914
ASP A 911
 None
 1.47A 3sfuA-3asiA:
undetectable		 3sfuA-3asiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		5 ASP A3144
THR A3076
THR A3074
TYR A3103
ASP A3100
 MG  A3701 (-2.9A)
None
ANP  A3400 (-4.1A)
ANP  A3400 (-4.0A)
ANP  A3400 (-4.7A)
 1.39A 3sfuA-3cmvA:
undetectable		 3sfuA-3cmvA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0r ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C

(Aquifex
aeolicus) 		PF02637
(GatB_Yqey)
PF02686
(Glu-tRNAGln)
PF02934
(GatB_N) 		5 ASP B 143
THR B  37
ASN B  36
GLY C  84
ASP C  83
 None
 1.15A 3sfuA-3h0rB:
undetectable		 3sfuA-3h0rB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjz TRANSALDOLASE B

(Prochlorococcus
marinus) 		PF00923
(TAL_FSA) 		5 SER A  97
THR A  98
THR A  34
ASN A  35
ASP A  20
 None
None
None
EDO  A 336 (-3.9A)
SO4  A 349 (-3.7A)
 1.36A 3sfuA-3hjzA:
undetectable		 3sfuA-3hjzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kea K1L

(Vaccinia virus) 		PF12796
(Ank_2) 		5 SER A 131
THR A 130
GLY A  94
ASP A  91
ASP A  92
 None
 1.45A 3sfuA-3keaA:
undetectable		 3sfuA-3keaA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C

(Thermus
thermophilus) 		PF02637
(GatB_Yqey)
PF02686
(Glu-tRNAGln)
PF02934
(GatB_N) 		5 ASP F 136
THR F  35
ASN F  34
GLY G  81
ASP G  80
 None
 1.08A 3sfuA-3kfuF:
undetectable		 3sfuA-3kfuF:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		7 ASP A 238
SER A 289
ASN A 298
TYR A 327
GLY A 328
ASP A 329
ASP A 330
 BUP  A 464 (-3.2A)
BUP  A 464 (-3.0A)
None
None
None
BUP  A 464 ( 4.1A)
None
 1.00A 3sfuA-3n6nA:
30.4		 3sfuA-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE

(Enterovirus A) 		PF00680
(RdRP_1) 		5 THR A 294
TYR A 327
GLY A 328
ASP A 329
ASP A 330
 None
None
None
BUP  A 464 ( 4.1A)
None
 0.58A 3sfuA-3n6nA:
30.4		 3sfuA-3n6nA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4g ANTIFREEZE PROTEIN

(Marinomonas
primoryensis) 		no annotation 5 ASP A 116
THR A 100
THR A 119
GLY A 137
ASP A 135
 None
None
None
CA  A 405 (-4.1A)
None
 1.05A 3sfuA-3p4gA:
undetectable		 3sfuA-3p4gA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzu ENDOGLUCANASE

(Bacillus
subtilis) 		PF00150
(Cellulase) 		5 SER A 208
THR A 206
ASN A 171
GLY A 172
ASP A 173
 None
 1.28A 3sfuA-3pzuA:
undetectable		 3sfuA-3pzuA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		5 ASP A 974
ASN A 957
GLY A 956
ASP A 958
ASP A 955
 None
 1.42A 3sfuA-3qcwA:
undetectable		 3sfuA-3qcwA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh4 ESTERASE LIPW

(Mycobacterium
marinum) 		PF07859
(Abhydrolase_3) 		5 ASP A 195
SER A 232
TYR A 263
ASP A 194
ASP A 262
 None
 1.48A 3sfuA-3qh4A:
undetectable		 3sfuA-3qh4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2u METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00753
(Lactamase_B) 		5 SER A 224
THR A 219
ASN A 220
GLY A 150
ASP A 151
 None
 1.45A 3sfuA-3r2uA:
undetectable		 3sfuA-3r2uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr8 OLIGORIBONUCLEASE

(Coxiella
burnetii) 		PF00929
(RNase_T) 		5 ASP A  59
THR A  16
ASN A  62
GLY A  17
ASP A  19
 None
 1.34A 3sfuA-3tr8A:
undetectable		 3sfuA-3tr8A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		5 ASP A 366
THR A 340
ASN A 341
GLY A 369
ASP A 368
 None
 1.16A 3sfuA-4c1nA:
undetectable		 3sfuA-4c1nA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csi CELLULASE

(Humicola grisea) 		PF00840
(Glyco_hydro_7) 		5 THR A  85
THR A  86
ASN A  87
GLY A  88
ASP A  89
 None
 1.44A 3sfuA-4csiA:
undetectable		 3sfuA-4csiA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cu9 BETA-GALACTOSIDASE

(Streptococcus
pneumoniae) 		no annotation 5 THR A1836
THR A1862
ASN A1863
GLY A1985
ASP A1905
 None
 1.23A 3sfuA-4cu9A:
undetectable		 3sfuA-4cu9A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		5 SER W 591
THR W 596
ASN W 600
GLY W 630
ASP W 629
 None
 1.45A 3sfuA-4f5xW:
2.3		 3sfuA-4f5xW:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 THR A1022
TYR A1051
GLY A1052
ASP A1053
ASP A1054
 None
C  G2008 ( 4.8A)
C  G2008 ( 4.0A)
CA  A2502 (-2.7A)
CA  A2503 (-3.5A)
 1.05A 3sfuA-4fwtA:
11.0		 3sfuA-4fwtA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi0 UREASE ACCESSORY
PROTEIN UREH

(Helicobacter
pylori) 		PF01774
(UreD) 		5 SER B 163
THR B 127
THR B 126
ASN B 125
GLY B 124
 None
 1.25A 3sfuA-4hi0B:
undetectable		 3sfuA-4hi0B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ASP A 541
ASN A 613
GLY A 667
ASP A 668
ASP A 669
 None
 0.92A 3sfuA-4k6mA:
22.2		 3sfuA-4k6mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ASP A 541
SER A 604
ASN A 613
ASP A 668
ASP A 669
 None
 1.28A 3sfuA-4k6mA:
22.2		 3sfuA-4k6mA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh3 ANTIGEN 43

(Escherichia
coli) 		PF16168
(AIDA) 		5 SER A  78
THR A  80
THR A  61
ASN A  60
GLY A  30
 None
 1.18A 3sfuA-4kh3A:
undetectable		 3sfuA-4kh3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtp RNA DEPENDENT RNA
POLYMERASE

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5) 		5 ASP A 541
ASN A 613
GLY A 667
ASP A 668
ASP A 669
 ASP  A 541 ( 0.6A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
ASP  A 668 ( 0.6A)
ASP  A 669 ( 0.6A)
 1.06A 3sfuA-4mtpA:
19.2		 3sfuA-4mtpA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtp RNA DEPENDENT RNA
POLYMERASE

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5) 		5 ASP A 541
SER A 604
ASN A 613
GLY A 667
ASP A 668
 ASP  A 541 ( 0.6A)
SER  A 604 ( 0.0A)
ASN  A 613 ( 0.6A)
GLY  A 667 ( 0.0A)
ASP  A 668 ( 0.6A)
 1.04A 3sfuA-4mtpA:
19.2		 3sfuA-4mtpA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		9 ASP A 247
SER A 300
THR A 305
THR A 306
ASN A 309
TYR A 341
GLY A 342
ASP A 343
ASP A 344
 None
None
None
None
None
2NG  A1101 ( 4.8A)
None
None
MG  A1102 (-3.4A)
 0.22A 3sfuA-4nruA:
57.2		 3sfuA-4nruA:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		6 ASP A 240
ASN A 302
TYR A 331
GLY A 332
ASP A 333
ASP A 334
 None
 0.64A 3sfuA-4nz0A:
32.5		 3sfuA-4nz0A:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy7 PUTATIVE SECRETED
CELLULOSE BINDING
PROTEIN

(Streptomyces
coelicolor) 		PF03067
(LPMO_10) 		5 ASP A 107
SER A 114
ASN A 117
GLY A 100
ASP A  99
 None
 1.49A 3sfuA-4oy7A:
undetectable		 3sfuA-4oy7A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		5 SER A 182
THR A 180
ASN A 144
GLY A 145
ASP A 147
 None
 1.20A 3sfuA-4xzbA:
undetectable		 3sfuA-4xzbA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzw ENDO-GLUCANASE
CHIMERA C10

(Geobacillus sp.
70PC53;
uncultured
bacterium) 		PF00150
(Cellulase) 		5 SER A 181
THR A 179
ASN A 144
GLY A 145
ASP A 146
 None
 1.20A 3sfuA-4xzwA:
undetectable		 3sfuA-4xzwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		6 ASP A 238
ASN A 298
TYR A 327
GLY A 328
ASP A 329
ASP A 330
 None
 0.62A 3sfuA-4zpdA:
31.3		 3sfuA-4zpdA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpd RNA-DIRECTED RNA
POLYMERASE

(Enterovirus B) 		PF00680
(RdRP_1) 		7 ASP A 238
SER A 289
THR A 294
TYR A 327
GLY A 328
ASP A 329
ASP A 330
 None
 0.72A 3sfuA-4zpdA:
31.3		 3sfuA-4zpdA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amp CELLOBIOHYDROLASE I

(Galactomyces
candidus) 		PF00840
(Glyco_hydro_7) 		5 ASP A 382
SER A 383
THR A 404
GLY A 407
ASP A 372
 None
 1.39A 3sfuA-5ampA:
undetectable		 3sfuA-5ampA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cy4 OLIGORIBONUCLEASE

(Acinetobacter
baumannii) 		PF00929
(RNase_T) 		5 ASP A  60
THR A  17
ASN A  63
GLY A  18
ASP A  20
 None
 1.39A 3sfuA-5cy4A:
undetectable		 3sfuA-5cy4A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 6 ASP B 374
THR B 444
TYR B 349
GLY B 350
ASP B 351
ASP B 352
 None
SO4  B 702 (-3.4A)
None
None
ATP  B 701 (-2.4A)
ATP  B 701 (-3.5A)
 0.78A 3sfuA-5cyrB:
16.0		 3sfuA-5cyrB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 THR B 443
THR B 444
TYR B 349
GLY B 350
ASP B 352
 SO4  B 702 (-4.4A)
SO4  B 702 (-3.4A)
None
None
ATP  B 701 (-3.5A)
 0.99A 3sfuA-5cyrB:
16.0		 3sfuA-5cyrB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 SER A 150
THR A 166
THR A 164
ASN A 168
GLY A 163
 None
LEU  A 602 ( 3.0A)
LEU  A 602 (-4.7A)
None
None
 1.36A 3sfuA-5ecoA:
undetectable		 3sfuA-5ecoA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 5 ASP B 266
SER B 324
GLY B 358
ASP B 359
ASP B 360
 None
 1.09A 3sfuA-5i61B:
20.9		 3sfuA-5i61B:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i61 POTENTIAL
RNA-DEPENDENT RNA
POLYMERASE

(Human
picobirnavirus) 		no annotation 5 ASP B 266
THR B 327
GLY B 358
ASP B 359
ASP B 360
 None
 0.82A 3sfuA-5i61B:
20.9		 3sfuA-5i61B:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq6 RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		6 ASP A 538
SER A 600
ASN A 609
GLY A 662
ASP A 663
ASP A 664
 None
 1.08A 3sfuA-5iq6A:
19.2		 3sfuA-5iq6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ASP A 538
ASN A 609
GLY A 662
ASP A 663
ASP A 664
 None
None
None
None
MG  A1006 (-2.7A)
 0.89A 3sfuA-5jjrA:
20.3		 3sfuA-5jjrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ASP A 538
SER A 600
GLY A 662
ASP A 663
ASP A 664
 None
None
None
None
MG  A1006 (-2.7A)
 1.15A 3sfuA-5jjrA:
20.3		 3sfuA-5jjrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		6 ASP A 539
THR A 606
ASN A 610
GLY A 662
ASP A 663
ASP A 664
 None
 1.21A 3sfuA-5k5mA:
19.9		 3sfuA-5k5mA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqo NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bacteroides
thetaiotaomicron) 		PF07944
(Glyco_hydro_127) 		5 THR A 475
THR A  39
ASN A  38
GLY A  24
ASP A  27
 None
 1.47A 3sfuA-5mqoA:
undetectable		 3sfuA-5mqoA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		5 THR A 169
ASN A 211
GLY A 163
ASP A 164
ASP A 161
 None
 1.34A 3sfuA-5odrA:
undetectable		 3sfuA-5odrA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ASP A 540
ASN A 612
GLY A 664
ASP A 665
ASP A 666
 None
 1.00A 3sfuA-5tmhA:
19.5		 3sfuA-5tmhA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud6 DIHYDRODIPICOLINATE
SYNTHASE

(Cyanidioschyzon
merolae) 		no annotation 5 ASP A 201
THR A  16
TYR A 145
GLY A 199
ASP A 200
 None
None
KPI  A 174 ( 3.7A)
KPI  A 174 ( 3.8A)
None
 1.35A 3sfuA-5ud6A:
undetectable		 3sfuA-5ud6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulu CADHERIN-23

(Mus musculus) 		no annotation 5 ASP A2072
THR A2124
ASN A2125
ASP A2074
ASP A2039
 CA  A2303 (-2.1A)
None
CA  A2303 (-2.9A)
CA  A2303 ( 3.3A)
None
 1.48A 3sfuA-5uluA:
undetectable		 3sfuA-5uluA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz8 CADHERIN-23

(Mus musculus) 		no annotation 5 SER A2504
THR A2507
GLY A2540
ASP A2536
ASP A2538
 None
 1.18A 3sfuA-5uz8A:
undetectable		 3sfuA-5uz8A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		6 ASP A 234
ASN A 293
TYR A 322
GLY A 323
ASP A 324
ASP A 325
 GTP  A 501 (-2.6A)
None
None
None
GTP  A 501 ( 4.2A)
None
 0.64A 3sfuA-5xe0A:
31.4		 3sfuA-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		5 SER A 284
ASN A 293
TYR A 322
ASP A 324
ASP A 325
 GTP  A 501 (-4.0A)
None
None
GTP  A 501 ( 4.2A)
None
 1.06A 3sfuA-5xe0A:
31.4		 3sfuA-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		5 SER A 284
THR A 289
TYR A 322
ASP A 324
ASP A 325
 GTP  A 501 (-4.0A)
None
None
GTP  A 501 ( 4.2A)
None
 1.06A 3sfuA-5xe0A:
31.4		 3sfuA-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		5 THR A 289
TYR A 322
GLY A 323
ASP A 324
ASP A 325
 None
None
None
GTP  A 501 ( 4.2A)
None
 0.61A 3sfuA-5xe0A:
31.4		 3sfuA-5xe0A:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 ASP A 350
ASN A 414
GLY A 447
ASP A 448
ASP A 449
 GOL  A 732 (-4.1A)
None
None
None
None
 0.89A 3sfuA-5y6rA:
24.4		 3sfuA-5y6rA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 ASP A 350
SER A 405
ASN A 414
ASP A 448
ASP A 449
 GOL  A 732 (-4.1A)
GOL  A 732 ( 4.7A)
None
None
None
 1.12A 3sfuA-5y6rA:
24.4		 3sfuA-5y6rA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgb CADHERIN-11,
CADHERIN-6 CHIMERA

(Mus musculus) 		no annotation 5 ASN A  56
TYR A  37
GLY A  55
ASP A  51
ASP A  52
 None
 1.29A 3sfuA-6cgbA:
undetectable		 3sfuA-6cgbA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
10
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 5 SER M 180
THR M 183
THR M 182
GLY p  79
ASP p  80
 None
 1.39A 3sfuA-6g2jM:
undetectable		 3sfuA-6g2jM:
10.43