SIMILAR PATTERNS OF AMINO ACIDS FOR 3SDR_A_210A822_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ASP A 351
ASP A 355
ARG A 493
ASP A 496
 MG  A 703 (-2.4A)
MG  A 703 (-2.7A)
3AG  A 900 (-2.5A)
MG  A 702 ( 2.6A)
 0.77A 3sdrA-1n21A:
37.7		 3sdrA-1n21A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ASP A 355
ASP A 509
ARG A 493
ASP A 496
 MG  A 703 (-2.7A)
MG  A 701 ( 4.4A)
3AG  A 900 (-2.5A)
MG  A 702 ( 2.6A)
 1.41A 3sdrA-1n21A:
37.7		 3sdrA-1n21A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ASP A 352
ASP A 356
ARG A 493
ASP A 496
 FPG  A 600 (-2.8A)
MN  A 602 (-2.5A)
FPG  A 600 (-3.8A)
MN  A 603 ( 2.9A)
 1.11A 3sdrA-2ongA:
37.4		 3sdrA-2ongA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		4 ASP A 924
ASP A 922
ARG A 625
ASP A 673
 CA  A   3 (-3.0A)
CA  A   3 (-3.5A)
None
None
 1.32A 3sdrA-2rhpA:
0.0		 3sdrA-2rhpA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		4 ASP A 290
ASP A 293
ARG A 151
ASP A 162
 None
 1.29A 3sdrA-2tddA:
0.6		 3sdrA-2tddA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 ASP A 256
ASP A 172
ARG A 230
ASP A 326
 None
 1.20A 3sdrA-2x05A:
0.4		 3sdrA-2x05A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		4 ASP A 367
ASP A 365
ARG A 311
ASP A 293
 None
 1.43A 3sdrA-2zblA:
5.6		 3sdrA-2zblA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		4 ASP A 371
ASP A 373
ARG A 258
ASP A 217
 None
 1.47A 3sdrA-3e1tA:
0.5		 3sdrA-3e1tA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifq E-CADHERIN
PLAKOGLOBIN

(Homo sapiens;
Mus musculus) 		PF00514
(Arm)
PF01049
(Cadherin_C) 		4 ASP A 449
ASP A 450
ARG C 630
ASP A 552
 None
 0.99A 3sdrA-3ifqA:
2.8		 3sdrA-3ifqA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orb SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Mus musculus) 		PF00149
(Metallophos) 		4 ASP A  90
ASP A 118
ARG A 279
ASP A 234
 FE  A 602 ( 3.4A)
ZN  A 601 ( 3.0A)
None
None
 1.38A 3sdrA-4orbA:
0.0		 3sdrA-4orbA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hl6 PUTATIVE GAF SENSOR
PROTEIN

(Burkholderia
vietnamiensis) 		PF13185
(GAF_2) 		4 ASP A 146
ASP A 143
ARG A  50
ASP A  49
 None
 1.32A 3sdrA-5hl6A:
1.1		 3sdrA-5hl6A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 4 ASP A 243
ASP A 241
ARG A 433
ASP A 133
 None
 1.38A 3sdrA-5i5jA:
undetectable		 3sdrA-5i5jA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ASP A 343
ASP A 347
ARG A 485
ASP A 488
 MN  A 702 (-2.7A)
MN  A 701 (-2.7A)
LA6  A 704 (-2.9A)
MN  A 703 ( 2.8A)
 0.62A 3sdrA-5uv2A:
38.8		 3sdrA-5uv2A:
29.18