SIMILAR PATTERNS OF AMINO ACIDS FOR 3S8P_A_SAMA500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 HIS A 499
SER A 280
GLU A 281
 None
 0.78A 3s8pA-1eovA:
undetectable		 3s8pA-1eovA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eso CU, ZN SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00080
(Sod_Cu) 		3 HIS A  46
SER A  54
GLU A  56
 CU  A 150 ( 3.3A)
None
None
 0.82A 3s8pA-1esoA:
0.0		 3s8pA-1esoA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		3 HIS A 213
SER A 217
GLU A 216
 None
 0.85A 3s8pA-1f6dA:
0.0		 3s8pA-1f6dA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu4 MICROBIAL
TRANSGLUTAMINASE

(Streptomyces
mobaraensis) 		PF09017
(Transglut_prok) 		3 HIS A 188
SER A 144
GLU A 143
 None
 0.84A 3s8pA-1iu4A:
0.0		 3s8pA-1iu4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		3 HIS A 211
SER A 288
GLU A 257
 ZN  A 501 ( 3.4A)
None
None
 0.93A 3s8pA-1krmA:
0.0		 3s8pA-1krmA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 HIS A 545
SER A 660
GLU A 658
 FE2  A 840 (-3.3A)
None
None
 0.81A 3s8pA-1loxA:
0.0		 3s8pA-1loxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		3 HIS A 184
SER A 218
GLU A 221
 None
 0.90A 3s8pA-1mt5A:
0.0		 3s8pA-1mt5A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1z GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Thermotoga
maritima) 		PF03009
(GDPD) 		3 HIS A  48
SER A  10
GLU A  15
 None
 0.90A 3s8pA-1o1zA:
0.0		 3s8pA-1o1zA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6k HPV11 REGULATORY
PROTEIN E2

(Alphapapillomavirus
10) 		PF00508
(PPV_E2_N) 		3 HIS A  32
SER A  40
GLU A  39
 None
 0.91A 3s8pA-1r6kA:
0.2		 3s8pA-1r6kA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r77 CELL WALL TARGETING
DOMAIN OF
GLYCYLGLYCINE
ENDOPEPTIDASE ALE-1

(Staphylococcus
capitis) 		PF08460
(SH3_5) 		3 HIS A 327
SER A 350
GLU A 349
 None
 0.89A 3s8pA-1r77A:
undetectable		 3s8pA-1r77A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbj PROSTAGLANDIN F
SYNTHASE

(Trypanosoma
brucei) 		PF00248
(Aldo_ket_red) 		3 HIS A 263
SER A 188
GLU A 163
 None
NAP  A3001 (-3.0A)
None
 0.80A 3s8pA-1vbjA:
undetectable		 3s8pA-1vbjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhh SONIC HEDGEHOG

(Mus musculus) 		PF01085
(HH_signal) 		3 HIS A 141
SER A  60
GLU A  54
 ZN  A 400 ( 3.2A)
None
None
 0.67A 3s8pA-1vhhA:
undetectable		 3s8pA-1vhhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz1 TRANSLATIONALLY
CONTROLLED TUMOR
PROTEIN

(Homo sapiens) 		PF00838
(TCTP) 		3 HIS A  77
SER A  15
GLU A  12
 None
 0.70A 3s8pA-1yz1A:
undetectable		 3s8pA-1yz1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8s CYTOCHROME C-L

(Methylobacterium
extorquens) 		PF13442
(Cytochrome_CBB3) 		3 HIS A 130
SER A  59
GLU A  58
 None
 0.88A 3s8pA-2c8sA:
undetectable		 3s8pA-2c8sA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fem CYTIDYLATE KINASE

(Escherichia
coli) 		PF02224
(Cytidylate_kin) 		3 HIS A 156
SER A 150
GLU A 153
 None
 0.81A 3s8pA-2femA:
undetectable		 3s8pA-2femA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gvi CONSERVED
HYPOTHETICAL PROTEIN

(Thermoplasma
acidophilum) 		PF02663
(FmdE) 		3 HIS A 102
SER A  51
GLU A  52
 ZN  A 302 ( 3.0A)
None
None
 0.91A 3s8pA-2gviA:
undetectable		 3s8pA-2gviA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy5 ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF10430
(Ig_Tie2_1) 		3 HIS A 177
SER A 142
GLU A 175
 NAG  A1140 ( 4.8A)
None
NAG  A1140 ( 4.6A)
 0.80A 3s8pA-2gy5A:
undetectable		 3s8pA-2gy5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibg PROTEIN HEDGEHOG

(Drosophila
melanogaster) 		PF01085
(HH_signal) 		3 HIS E 200
SER E 119
GLU E 113
 None
 0.82A 3s8pA-2ibgE:
undetectable		 3s8pA-2ibgE:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		3 HIS A 185
SER A 112
GLU A 113
 None
 0.73A 3s8pA-2id5A:
undetectable		 3s8pA-2id5A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		3 HIS A 209
SER A 230
GLU A 206
 None
 0.85A 3s8pA-2id5A:
undetectable		 3s8pA-2id5A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jep XYLOGLUCANASE

(Paenibacillus
pabuli) 		PF00150
(Cellulase) 		3 HIS A 131
SER A 179
GLU A 178
 None
 0.81A 3s8pA-2jepA:
undetectable		 3s8pA-2jepA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lt1 CARD PROTEIN

(Myxococcus
xanthus) 		PF02559
(CarD_CdnL_TRCF) 		3 HIS A   3
SER A   8
GLU A   6
 None
 0.91A 3s8pA-2lt1A:
undetectable		 3s8pA-2lt1A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n5j RIBONUCLEASE ZC3H12A

(Mus musculus) 		no annotation 3 HIS A  88
SER A  63
GLU A  64
 None
 0.87A 3s8pA-2n5jA:
undetectable		 3s8pA-2n5jA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3f PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YBBH

(Bacillus
subtilis) 		PF01418
(HTH_6) 		3 HIS A  32
SER A  37
GLU A  36
 SO4  A 203 (-3.8A)
MLY  A  33 ( 2.7A)
MLY  A  33 ( 4.3A)
 0.93A 3s8pA-2o3fA:
undetectable		 3s8pA-2o3fA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v91 STRICTOSIDINE
SYNTHASE

(Rauvolfia
serpentina) 		PF03088
(Str_synth) 		3 HIS A 277
SER A 269
GLU A 271
 S55  A1334 (-4.2A)
S55  A1334 ( 3.7A)
None
 0.92A 3s8pA-2v91A:
undetectable		 3s8pA-2v91A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdu TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE-ASSOCI
ATED WD REPEAT
PROTEIN TRM82

(Saccharomyces
cerevisiae) 		no annotation 3 HIS B  37
SER B 408
GLU B 405
 None
 0.88A 3s8pA-2vduB:
undetectable		 3s8pA-2vduB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wg3 DESERT HEDGEHOG
PROTEIN N-PRODUCT

(Homo sapiens) 		PF01085
(HH_signal) 		3 HIS A 141
SER A  60
GLU A  54
 ZN  A1199 (-3.3A)
None
None
 0.68A 3s8pA-2wg3A:
undetectable		 3s8pA-2wg3A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 HIS A 303
SER A 169
GLU A 168
 None
 0.92A 3s8pA-2xf8A:
undetectable		 3s8pA-2xf8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 HIS A 513
SER A 526
GLU A 411
 3ES  A1635 (-3.9A)
None
ZN  A1628 ( 2.4A)
 0.88A 3s8pA-2xy9A:
undetectable		 3s8pA-2xy9A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 HIS A 491
SER A 504
GLU A 389
 3ES  A1611 (-3.9A)
None
ZN  A1620 ( 2.4A)
 0.88A 3s8pA-2xydA:
undetectable		 3s8pA-2xydA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		3 HIS D 480
SER D 487
GLU D 486
 None
 0.87A 3s8pA-2ynmD:
undetectable		 3s8pA-2ynmD:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Geobacillus
kaustophilus) 		PF00215
(OMPdecase) 		3 HIS A 147
SER A 155
GLU A 154
 None
 0.88A 3s8pA-2yytA:
undetectable		 3s8pA-2yytA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes) 		PF00149
(Metallophos) 		3 HIS A  10
SER A  13
GLU A  59
 FE2  A 275 ( 3.6A)
None
None
 0.89A 3s8pA-2zoaA:
undetectable		 3s8pA-2zoaA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ima CYSTEINE PROTEINASE
INHIBITOR

(Colocasia
esculenta) 		PF16845
(SQAPI) 		3 HIS B  57
SER B  90
GLU B  88
 None
 0.89A 3s8pA-3imaB:
undetectable		 3s8pA-3imaB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7h INDIAN HEDGEHOG
PROTEIN

(Homo sapiens) 		PF01085
(HH_signal) 		3 HIS B 145
SER B  64
GLU B  58
 ZN  B1001 (-3.2A)
None
None
 0.68A 3s8pA-3k7hB:
undetectable		 3s8pA-3k7hB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgz CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Rhodopseudomonas
palustris) 		PF07883
(Cupin_2) 		3 HIS A  87
SER A  48
GLU A  66
 None
 0.78A 3s8pA-3kgzA:
undetectable		 3s8pA-3kgzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kie CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		3 HIS A 229
SER A 312
GLU A 682
 None
 0.85A 3s8pA-3kieA:
undetectable		 3s8pA-3kieA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kst ENDO-1,4-BETA-XYLANA
SE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		3 HIS A 233
SER A 230
GLU A 214
 None
 0.53A 3s8pA-3kstA:
undetectable		 3s8pA-3kstA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3p IPAH9.8

(Shigella
flexneri) 		PF14496
(NEL) 		3 HIS A 282
SER A 336
GLU A 335
 None
 0.70A 3s8pA-3l3pA:
undetectable		 3s8pA-3l3pA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Homo sapiens) 		PF01409
(tRNA-synt_2d) 		3 HIS A 327
SER A 352
GLU A 374
 None
None
PHE  A 509 (-3.6A)
 0.68A 3s8pA-3l4gA:
undetectable		 3s8pA-3l4gA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Streptococcus
suis) 		PF01297
(ZnuA) 		3 HIS A  68
SER A 247
GLU A 246
 ZN  A 401 (-3.6A)
None
None
 0.83A 3s8pA-3mfqA:
undetectable		 3s8pA-3mfqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1q DESERT HEDGEHOG
PROTEIN

(Homo sapiens) 		no annotation 3 HIS B 141
SER B  60
GLU B  54
 ZN  B 190 (-3.5A)
None
None
 0.73A 3s8pA-3n1qB:
undetectable		 3s8pA-3n1qB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc3 D-RIBULOSE-5-PHOSPHA
TE-3-EPIMERASE

(Homo sapiens) 		PF00834
(Ribul_P_3_epim) 		3 HIS A  51
SER A  56
GLU A  55
 None
 0.73A 3s8pA-3qc3A:
undetectable		 3s8pA-3qc3A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpb URIDINE
PHOSPHORYLASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		3 HIS A 208
SER A  78
GLU A  82
 None
 0.73A 3s8pA-3qpbA:
undetectable		 3s8pA-3qpbA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		3 HIS A 226
SER A  27
GLU A  26
 None
 0.92A 3s8pA-3stgA:
undetectable		 3s8pA-3stgA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tch PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		3 HIS A 168
SER A  89
GLU A  88
 None
 0.83A 3s8pA-3tchA:
undetectable		 3s8pA-3tchA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty2 5'-NUCLEOTIDASE SURE

(Coxiella
burnetii) 		PF01975
(SurE) 		3 HIS A 231
SER A 235
GLU A 184
 None
 0.86A 3s8pA-3ty2A:
undetectable		 3s8pA-3ty2A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3y THREE PRIME REPAIR
EXONUCLEASE 1

(Mus musculus) 		no annotation 3 HIS B 200
SER B  68
GLU B  33
 None
 0.88A 3s8pA-3u3yB:
undetectable		 3s8pA-3u3yB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ve2 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		3 HIS A 273
SER A 229
GLU A 228
 None
 0.91A 3s8pA-3ve2A:
undetectable		 3s8pA-3ve2A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3von UBIQUITIN
THIOESTERASE OTUB1

(Homo sapiens) 		PF10275
(Peptidase_C65) 		3 HIS A 265
SER A 215
GLU A 214
 None
 0.89A 3s8pA-3vonA:
undetectable		 3s8pA-3vonA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE

(Xenopus laevis) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 HIS A 358
SER A 366
GLU A 365
 None
 0.92A 3s8pA-3w0lA:
undetectable		 3s8pA-3w0lA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcz ALDO-KETO REDUCTASE
2E

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		3 HIS A 292
SER A 207
GLU A 182
 None
NAP  A 401 (-2.8A)
None
 0.73A 3s8pA-3wczA:
undetectable		 3s8pA-3wczA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum) 		PF00224
(PK)
PF02887
(PK_C) 		3 HIS A 399
SER A 419
GLU A 418
 None
 0.92A 3s8pA-4drsA:
undetectable		 3s8pA-4drsA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwe UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15421
(Polysacc_deac_3) 		3 HIS A 390
SER A 425
GLU A 424
 None
 0.88A 3s8pA-4dweA:
undetectable		 3s8pA-4dweA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e22 CYTIDYLATE KINASE

(Yersinia
pseudotuberculosis) 		PF02224
(Cytidylate_kin) 		3 HIS A 156
SER A 150
GLU A 153
 None
 0.92A 3s8pA-4e22A:
undetectable		 3s8pA-4e22A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huh TAIL CONNECTOR
PROTEIN GP15

(Escherichia
virus T4) 		PF16724
(T4-gp15_tss) 		3 HIS A  78
SER A 189
GLU A 119
 None
 0.87A 3s8pA-4huhA:
undetectable		 3s8pA-4huhA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip3 ORF169B

(Shigella
flexneri) 		no annotation 3 HIS A 199
SER A 193
GLU A 196
 None
 0.85A 3s8pA-4ip3A:
undetectable		 3s8pA-4ip3A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhu 9C2 TCR GAMMA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 HIS G  74
SER G  21
GLU G  23
 None
 0.73A 3s8pA-4lhuG:
undetectable		 3s8pA-4lhuG:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		3 HIS A 126
SER A 156
GLU A 155
 None
 0.89A 3s8pA-4lomA:
undetectable		 3s8pA-4lomA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		3 HIS A 173
SER A 202
GLU A 229
 MN  A 401 ( 3.4A)
None
None
 0.86A 3s8pA-4ng3A:
undetectable		 3s8pA-4ng3A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4noz ORGANIC
HYDROPEROXIDE
RESISTANCE PROTEIN

(Burkholderia
cenocepacia) 		PF02566
(OsmC) 		3 HIS A  11
SER A  27
GLU A  26
 None
 0.83A 3s8pA-4nozA:
undetectable		 3s8pA-4nozA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqq DEOXYRIBONUCLEOSIDE
REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		3 HIS A  78
SER A  66
GLU A  69
 None
 0.88A 3s8pA-4oqqA:
undetectable		 3s8pA-4oqqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 HIS A 229
SER A 236
GLU A 232
 None
 0.50A 3s8pA-4p52A:
undetectable		 3s8pA-4p52A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rly NAV1.2 - ANKB
CHIMERA

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		3 HIS A2069
SER A1124
GLU A1123
 None
 0.93A 3s8pA-4rlyA:
undetectable		 3s8pA-4rlyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1a MITORIBOSOMAL
PROTEIN ML48, MRPL48

(Sus scrofa) 		no annotation 3 HIS k 153
SER k 105
GLU k 104
 None
 0.81A 3s8pA-4v1ak:
undetectable		 3s8pA-4v1ak:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 HIS A 128
SER A 171
GLU A 170
 None
 0.83A 3s8pA-4v2xA:
undetectable		 3s8pA-4v2xA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		3 HIS A 150
SER A 110
GLU A 115
 CAC  A 501 (-3.8A)
None
None
 0.90A 3s8pA-4yn5A:
undetectable		 3s8pA-4yn5A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		3 HIS B 929
SER B1119
GLU B1012
 None
 0.74A 3s8pA-4zktB:
undetectable		 3s8pA-4zktB:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 HIS A 406
SER A 380
GLU A 378
 None
 0.77A 3s8pA-4zlgA:
undetectable		 3s8pA-4zlgA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrq TRANSCOBALAMIN-2

(Homo sapiens) 		PF01122
(Cobalamin_bind)
PF14478
(DUF4430) 		3 HIS A 345
SER A 365
GLU A 353
 None
 0.86A 3s8pA-4zrqA:
undetectable		 3s8pA-4zrqA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		3 HIS A 497
SER A 510
GLU A 395
 MLT  A1615 (-4.0A)
None
ZN  A1616 (-2.4A)
 0.80A 3s8pA-5a2rA:
undetectable		 3s8pA-5a2rA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		3 HIS B 543
SER B 368
GLU B 370
 None
 0.74A 3s8pA-5b4xB:
undetectable		 3s8pA-5b4xB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b71 SKY59 FAB HEAVY
CHAIN
COMPLEMENT C5 BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
no annotation 		3 HIS B  30
SER E 112
GLU E 105
 None
 0.67A 3s8pA-5b71B:
undetectable		 3s8pA-5b71B:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		3 HIS A 145
SER A 150
GLU A 148
 None
 0.73A 3s8pA-5bt8A:
undetectable		 3s8pA-5bt8A:
20.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cpr HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1

(Homo sapiens) 		PF00856
(SET) 		3 HIS B  98
SER B 205
GLU B 206
 SAM  B 402 (-3.7A)
SAM  B 402 (-2.7A)
SAM  B 402 (-2.9A)
 0.19A 3s8pA-5cprB:
38.0		 3s8pA-5cprB:
97.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diz PROTEINACEOUS RNASE
P 2

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		3 HIS A 399
SER A 366
GLU A 365
 None
 0.77A 3s8pA-5dizA:
undetectable		 3s8pA-5dizA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 HIS A 103
SER A 146
GLU A 145
 None
 0.80A 3s8pA-5e0cA:
undetectable		 3s8pA-5e0cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF01761
(DHQ_synthase) 		3 HIS A 246
SER A 254
GLU A 253
 MG  A 401 (-3.6A)
None
None
 0.87A 3s8pA-5eksA:
undetectable		 3s8pA-5eksA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC
CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis;
Bacillus
subtilis) 		PF02463
(SMC_N)
PF02463
(SMC_N) 		3 HIS B1069
SER A 159
GLU A 162
 None
 0.91A 3s8pA-5h67B:
undetectable		 3s8pA-5h67B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF08801
(Nucleoporin_N) 		3 HIS A 758
SER A 766
GLU A 765
 None
 0.92A 3s8pA-5haxA:
undetectable		 3s8pA-5haxA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		3 HIS A  85
SER A  94
GLU A  93
 None
 0.83A 3s8pA-5hmpA:
undetectable		 3s8pA-5hmpA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itw DIHYDROANTICAPSIN
7-DEHYDROGENASE

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		3 HIS A 123
SER A  75
GLU A  74
 None
 0.80A 3s8pA-5itwA:
undetectable		 3s8pA-5itwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12

(Homo sapiens) 		PF00443
(UCH) 		3 HIS A 243
SER A 227
GLU A 241
 None
 0.82A 3s8pA-5k1cA:
undetectable		 3s8pA-5k1cA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		3 HIS A  41
SER A  57
GLU A  59
 None
 0.92A 3s8pA-5k5tA:
undetectable		 3s8pA-5k5tA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA

(Staphylococcus
aureus) 		PF03255
(ACCA) 		3 HIS A 249
SER A 262
GLU A 214
 None
 0.89A 3s8pA-5kdrA:
undetectable		 3s8pA-5kdrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		3 HIS A1808
SER A1626
GLU A1628
 None
 0.92A 3s8pA-5lkiA:
undetectable		 3s8pA-5lkiA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msn DCC1 PROTEIN

(Saccharomyces
cerevisiae) 		PF09724
(Dcc1) 		3 HIS A 212
SER A 171
GLU A 229
 None
 0.92A 3s8pA-5msnA:
undetectable		 3s8pA-5msnA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvo FOXE

(Rhodobacter sp.
SW2) 		no annotation 3 HIS A 242
SER A 237
GLU A 238
 None
 0.92A 3s8pA-5mvoA:
undetectable		 3s8pA-5mvoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 HIS A 281
SER A 341
GLU A 339
 None
 0.85A 3s8pA-5ngkA:
undetectable		 3s8pA-5ngkA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqd DUMPY: SHORTER THAN
WILD-TYPE

(Caenorhabditis
elegans) 		no annotation 3 HIS A1580
SER A1252
GLU A1294
 None
 0.91A 3s8pA-5uqdA:
undetectable		 3s8pA-5uqdA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqj U6 SNRNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF09749
(HVSL) 		3 HIS A 149
SER A  77
GLU A 280
 None
 0.56A 3s8pA-5uqjA:
undetectable		 3s8pA-5uqjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vzj EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 HIS J 181
SER J 413
GLU J 414
 None
 0.82A 3s8pA-5vzjJ:
undetectable		 3s8pA-5vzjJ:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvs GDP/UDP-N,N'-DIACETY
LBACILLOSAMINE
2-EPIMERASE
(HYDROLYZING)

(Acinetobacter
baumannii) 		no annotation 3 HIS A 180
SER A 294
GLU A 295
 None
None
UDP  A 402 (-3.1A)
 0.76A 3s8pA-5xvsA:
undetectable		 3s8pA-5xvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1a -

(-) 		no annotation 3 HIS A 231
SER A  90
GLU A  20
 None
 0.82A 3s8pA-5y1aA:
undetectable		 3s8pA-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 3 HIS C 634
SER C 378
GLU C 375
 None
None
GOL  C 814 (-3.2A)
 0.89A 3s8pA-5y6qC:
undetectable		 3s8pA-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar3 GSI-IIC RT

(Geobacillus
stearothermophilus) 		no annotation 3 HIS A 313
SER A 307
GLU A 310
 None
 0.82A 3s8pA-6ar3A:
undetectable		 3s8pA-6ar3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b1z GLUTAMATE--TRNA
LIGASE

(Elizabethkingia
anophelis) 		PF00749
(tRNA-synt_1c) 		3 HIS A 405
SER A 409
GLU A 408
 None
 0.76A 3s8pA-6b1zA:
undetectable		 3s8pA-6b1zA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 3 HIS A  52
SER A 231
GLU A 230
 None
 0.89A 3s8pA-6c66A:
undetectable		 3s8pA-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 3 HIS A 232
SER A 239
GLU A 246
 None
 0.83A 3s8pA-6eotA:
undetectable		 3s8pA-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X

(Clostridium
botulinum) 		no annotation 3 HIS A 231
SER A 349
GLU A 348
 None
 0.93A 3s8pA-6f4eA:
undetectable		 3s8pA-6f4eA:
undetectable