SIMILAR PATTERNS OF AMINO ACIDS FOR 3S79_A_ASDA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 ILE A 193
PHE A 269
ILE A  62
ALA A 191
VAL A 222
 None
 1.26A 3s79A-1ayeA:
0.0		 3s79A-1ayeA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4f EPHB2

(Homo sapiens) 		PF00536
(SAM_1) 		5 ILE A  67
ILE A  21
VAL A  52
LEU A  50
MET A  46
 None
 1.28A 3s79A-1b4fA:
undetectable		 3s79A-1b4fA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd CARBOXYPEPTIDASE A2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 ILE A 549
PHE A 625
ILE A 417
ALA A 547
VAL A 578
 None
 1.26A 3s79A-1dtdA:
undetectable		 3s79A-1dtdA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecx AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00266
(Aminotran_5) 		5 ARG A 350
ILE A 155
ALA A 148
VAL A 334
LEU A 335
 CYS  A 502 (-2.4A)
None
None
None
None
 1.26A 3s79A-1ecxA:
undetectable		 3s79A-1ecxA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuu YEAST INITIATION
FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		5 ILE A 167
VAL A 210
LEU A 208
MET A 203
LEU A  62
 None
 1.23A 3s79A-1fuuA:
undetectable		 3s79A-1fuuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i31 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		5 ILE A 263
PHE A 265
VAL A 401
MET A 202
LEU A 404
 None
 1.28A 3s79A-1i31A:
0.0		 3s79A-1i31A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 ARG A 359
PHE A 118
THR A  75
VAL A  82
LEU A  83
 None
 1.27A 3s79A-1k0gA:
0.0		 3s79A-1k0gA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kea POSSIBLE G-T
MISMATCHES REPAIR
ENZYME

(Methanothermobacter
thermautotrophicus) 		PF00730
(HhH-GPD) 		5 PHE A 155
ALA A 168
VAL A 143
LEU A 189
LEU A 176
 None
 1.27A 3s79A-1keaA:
0.0		 3s79A-1keaA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oru YUAD PROTEIN

(Bacillus
subtilis) 		no annotation 5 ILE A  35
PHE A  30
ALA A  15
THR A  22
LEU A  12
 None
 1.21A 3s79A-1oruA:
undetectable		 3s79A-1oruA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ILE A 222
ALA A 221
THR A 219
LEU A 166
LEU A 205
 None
 1.28A 3s79A-1qgzA:
undetectable		 3s79A-1qgzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1trf TROPONIN C

(Meleagris
gallopavo) 		PF13833
(EF-hand_8) 		5 PHE A  75
ALA A  31
ASP A  30
VAL A  45
LEU A  49
 None
 1.19A 3s79A-1trfA:
undetectable		 3s79A-1trfA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		5 ARG A 327
PHE A 298
ILE A 156
ALA A 150
THR A 148
 None
None
None
None
PLP  A 513 (-3.9A)
 1.16A 3s79A-1v72A:
undetectable		 3s79A-1v72A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w94 PROBABLE BRIX-DOMAIN
RIBOSOMAL BIOGENESIS
PROTEIN

(Methanothermobacter
thermautotrophicus) 		no annotation 5 ILE A  23
ALA A 142
LEU A 103
MET A 107
LEU A 146
 None
 1.19A 3s79A-1w94A:
undetectable		 3s79A-1w94A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 PHE A 131
ILE A  43
ALA A  44
VAL A 126
LEU A 123
 None
 1.28A 3s79A-1wp9A:
undetectable		 3s79A-1wp9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		5 ILE A 191
PHE A 195
ASP A 180
THR A 147
LEU A 214
 None
None
ZN  A 303 ( 3.3A)
None
None
 1.11A 3s79A-1xp3A:
undetectable		 3s79A-1xp3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yht DSPB

(Aggregatibacter
actinomycetemcomitans) 		PF00728
(Glyco_hydro_20) 		5 TRP A 302
ILE A 322
THR A  19
LEU A 349
LEU A 277
 None
 1.24A 3s79A-1yhtA:
undetectable		 3s79A-1yhtA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw1 PROTEIN YTNJ

(Bacillus
subtilis) 		PF00296
(Bac_luciferase) 		5 PHE A 215
ILE A 267
ALA A 383
ASP A 384
LEU A 426
 None
 1.20A 3s79A-1yw1A:
undetectable		 3s79A-1yw1A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 ILE A  43
ALA A  14
THR A  18
VAL A  34
LEU A  76
 None
 1.22A 3s79A-2awaA:
undetectable		 3s79A-2awaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axq SACCHAROPINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		5 ALA A  50
THR A  30
VAL A  64
LEU A  61
LEU A   8
 None
 1.27A 3s79A-2axqA:
undetectable		 3s79A-2axqA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8e CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 ILE A 571
ASP A 424
THR A 428
VAL A 635
LEU A 626
 None
 1.28A 3s79A-2b8eA:
undetectable		 3s79A-2b8eA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg5 PHOSPHOENOLPYRUVATE-
PROTEIN KINASE

(Caldanaerobacter
subterraneus) 		PF02896
(PEP-utilizers_C) 		5 ILE A 377
ALA A 376
THR A 372
LEU A 345
LEU A 334
 None
 1.21A 3s79A-2bg5A:
undetectable		 3s79A-2bg5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ezv TYPE II RESTRICTION
ENZYME SFII

(Streptomyces
fimbriatus) 		PF11487
(RestrictionSfiI) 		5 ARG A  84
ALA A  61
THR A  58
VAL A  99
LEU A  98
 None
 1.26A 3s79A-2ezvA:
undetectable		 3s79A-2ezvA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f28 SIALIDASE 2

(Homo sapiens) 		PF13088
(BNR_2) 		5 ILE A 191
ASP A 215
THR A 216
VAL A 244
LEU A 240
 None
 1.22A 3s79A-2f28A:
undetectable		 3s79A-2f28A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8t ARGONAUTE PROTEIN

(Aquifex
aeolicus) 		PF02171
(Piwi) 		5 ILE A 115
PHE A 114
ILE A 138
LEU A 157
LEU A 159
 U  C  25 ( 4.6A)
None
U  C  25 ( 4.2A)
None
None
 1.23A 3s79A-2f8tA:
undetectable		 3s79A-2f8tA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ful EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5

(Saccharomyces
cerevisiae) 		PF02020
(W2) 		5 ILE A 314
PHE A 311
ALA A 276
VAL A 290
LEU A 295
 None
 1.14A 3s79A-2fulA:
undetectable		 3s79A-2fulA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mtc DECORIN-BINDING
PROTEIN A

(Borreliella
burgdorferi) 		PF02352
(Decorin_bind) 		5 ILE A  99
PHE A  95
ALA A 103
THR A 109
LEU A  38
 None
 1.16A 3s79A-2mtcA:
undetectable		 3s79A-2mtcA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0l LIPOATE-PROTEIN
LIGASE A

(Streptococcus
agalactiae) 		PF03099
(BPL_LplA_LipB) 		5 PHE A 127
ALA A   9
LEU A 239
MET A 238
LEU A  49
 None
 1.05A 3s79A-2p0lA:
undetectable		 3s79A-2p0lA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Homo sapiens) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		5 PHE A 372
ILE A 300
THR A 295
LEU A 434
MET A 458
 None
 1.15A 3s79A-2pz1A:
undetectable		 3s79A-2pz1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv3 VACUOLATING
CYTOTOXIN

(Helicobacter
pylori) 		PF02691
(VacA) 		5 ILE A 514
PHE A 512
ILE A 476
THR A 502
VAL A 559
 None
 0.91A 3s79A-2qv3A:
undetectable		 3s79A-2qv3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 PHE A  83
ALA A 115
VAL A 119
LEU A  73
LEU A 264
 None
 1.22A 3s79A-2rcbA:
undetectable		 3s79A-2rcbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4y URIDYLATE KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		5 ALA A 148
THR A 145
LEU A  21
MET A  91
LEU A  16
 None
GTP  A1243 (-4.5A)
None
None
None
 1.25A 3s79A-2v4yA:
undetectable		 3s79A-2v4yA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy CATION-TRANSPORTING
ATPASE

(Archaeoglobus
fulgidus) 		PF00702
(Hydrolase) 		5 ILE I 571
ASP I 424
THR I 428
VAL I 635
LEU I 626
 None
 1.29A 3s79A-2voyI:
undetectable		 3s79A-2voyI:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		5 ILE A  66
ALA A  92
VAL A 131
LEU A 174
LEU A  48
 None
 1.28A 3s79A-2w6rA:
undetectable		 3s79A-2w6rA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6r IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		5 ILE A 192
ALA A 218
VAL A   5
LEU A  48
LEU A 174
 None
 1.27A 3s79A-2w6rA:
undetectable		 3s79A-2w6rA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aal PROBABLE
ENDONUCLEASE 4

(Geobacillus
kaustophilus) 		PF01261
(AP_endonuc_2) 		5 ILE A 190
PHE A 194
ASP A 179
THR A 146
LEU A 207
 None
None
FE  A 302 ( 3.2A)
None
None
 1.15A 3s79A-3aalA:
undetectable		 3s79A-3aalA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aal PROBABLE
ENDONUCLEASE 4

(Geobacillus
kaustophilus) 		PF01261
(AP_endonuc_2) 		5 ILE A 190
PHE A 194
ASP A 179
THR A 146
LEU A 213
 None
None
FE  A 302 ( 3.2A)
None
None
 1.15A 3s79A-3aalA:
undetectable		 3s79A-3aalA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
fragilis) 		PF13419
(HAD_2) 		5 ILE A 132
PHE A 129
ILE A 108
MET A 124
LEU A  14
 None
 1.21A 3s79A-3d6jA:
undetectable		 3s79A-3d6jA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		5 ARG A 100
ILE A 115
ALA A 299
THR A 303
VAL A 364
 HEM  A 500 (-2.4A)
HEM  A 500 (-4.0A)
HEM  A 500 ( 3.3A)
4PZ  A 501 ( 2.8A)
HEM  A 500 ( 4.4A)
 0.72A 3s79A-3e4eA:
37.3		 3s79A-3e4eA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehd UNCHARACTERIZED
CONSERVED PROTEIN

(Enterococcus
faecalis) 		PF05014
(Nuc_deoxyrib_tr) 		5 ILE A  56
ALA A  57
ASP A  60
THR A  61
VAL A  89
 None
None
GOL  A1001 (-4.2A)
None
None
 0.99A 3s79A-3ehdA:
undetectable		 3s79A-3ehdA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana) 		PF04371
(PAD_porph) 		5 PHE A  92
ILE A  54
ALA A  51
VAL A  82
MET A  85
 None
 1.16A 3s79A-3h7kA:
undetectable		 3s79A-3h7kA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ARG A 454
ILE A 450
PHE A 451
ALA A 417
LEU A 474
 None
 1.22A 3s79A-3hdxA:
undetectable		 3s79A-3hdxA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 284
ILE A 209
ALA A 236
ASP A 213
LEU A 273
 None
 1.19A 3s79A-3ip1A:
undetectable		 3s79A-3ip1A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ILE A 315
ALA A 154
THR A 152
VAL A  65
LEU A 143
 None
 1.27A 3s79A-3jv7A:
undetectable		 3s79A-3jv7A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf0 NITROGEN REGULATORY
PROTEIN P-II

(Mycobacterium
tuberculosis) 		PF00543
(P-II) 		5 ILE A  69
ALA A  23
VAL A  63
MET A   1
LEU A 112
 None
 0.86A 3s79A-3lf0A:
undetectable		 3s79A-3lf0A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		5 ILE A 841
ALA A 838
THR A 807
LEU A 684
LEU A 802
 None
 1.27A 3s79A-3m62A:
undetectable		 3s79A-3m62A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhu DIHYDROOROTATE
DEHYDROGENASE

(Leishmania
major) 		PF01180
(DHO_dh) 		5 PHE A  96
ILE A 246
ALA A 266
VAL A   5
LEU A   8
 None
 1.25A 3s79A-3mhuA:
undetectable		 3s79A-3mhuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2

(Saccharomyces
cerevisiae) 		PF10193
(Telomere_reg-2) 		5 ARG A 467
ILE A 466
ILE A 483
ALA A 480
LEU A 544
 None
 1.25A 3s79A-3o4zA:
undetectable		 3s79A-3o4zA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 ILE A 452
ILE A 420
ALA A 454
VAL A 470
LEU A 474
 None
 1.21A 3s79A-3o8oA:
undetectable		 3s79A-3o8oA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 5 ILE A 128
PHE A 129
ILE A  92
ASP A  90
LEU A 116
 None
 1.17A 3s79A-3oy2A:
undetectable		 3s79A-3oy2A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 5 ILE A 378
ALA A 252
LEU A 273
MET A 262
LEU A 281
 None
 1.22A 3s79A-3pf7A:
undetectable		 3s79A-3pf7A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qll CITRATE LYASE

(Yersinia pestis) 		PF03328
(HpcH_HpaI) 		5 PHE A 152
ALA A 159
ASP A 160
LEU A 172
LEU A 134
 None
 1.27A 3s79A-3qllA:
undetectable		 3s79A-3qllA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		5 ILE A 255
ALA A 256
THR A 260
VAL A 303
LEU A 305
 D12  A 509 ( 4.1A)
HEM  A 501 ( 3.5A)
HEM  A 501 (-3.4A)
HEM  A 501 (-4.7A)
None
 0.93A 3s79A-3r9bA:
29.9		 3s79A-3r9bA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT

(Thermus
aquaticus) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 ILE B 207
ALA B 178
LEU B 214
MET B   1
LEU B 220
 None
 1.16A 3s79A-3ufxB:
undetectable		 3s79A-3ufxB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE A 579
ALA A 605
VAL A 566
MET A 610
LEU A 628
 None
 1.03A 3s79A-3uk1A:
undetectable		 3s79A-3uk1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2h D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ILE A 135
ILE A 124
ALA A 123
LEU A 113
LEU A 163
 None
 1.19A 3s79A-3v2hA:
undetectable		 3s79A-3v2hA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ARG A 122
ILE A  68
ILE A  62
THR A  37
LEU A  85
 None
 1.23A 3s79A-3vc7A:
undetectable		 3s79A-3vc7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6j PHOSPHOSERINE
PHOSPHATASE

(Thermococcus
onnurineus) 		PF12710
(HAD) 		5 ASP A 110
VAL A   4
LEU A 147
MET A 149
LEU A  84
 None
 1.10A 3s79A-4b6jA:
undetectable		 3s79A-4b6jA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ciu CHAPERONE PROTEIN
CLPB

(Escherichia
coli) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 ARG A 351
ILE A 536
ALA A 372
THR A 375
VAL A 343
 None
 1.20A 3s79A-4ciuA:
undetectable		 3s79A-4ciuA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ct3 ORF30/ORF32

(Staphylococcus
virus K) 		PF05257
(CHAP) 		5 ILE A 159
ILE A 118
THR A  72
VAL A  70
LEU A  65
 None
CMH  A1166 (-4.7A)
None
None
None
 1.26A 3s79A-4ct3A:
undetectable		 3s79A-4ct3A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezi UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 ILE A 103
ALA A 192
THR A 201
LEU A 215
LEU A 171
 None
 1.15A 3s79A-4eziA:
undetectable		 3s79A-4eziA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		5 ILE A 225
PHE A 258
ILE A 210
ALA A 209
LEU A 244
 None
 1.28A 3s79A-4ffcA:
undetectable		 3s79A-4ffcA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 ILE A 555
PHE A 556
TRP A 552
VAL A 651
LEU A 620
 None
 1.17A 3s79A-4knhA:
undetectable		 3s79A-4knhA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kq8 CYTOCHROME P450 19A1

(Homo sapiens) 		PF00067
(p450) 		12 ARG A 115
ILE A 133
PHE A 134
TRP A 224
ILE A 305
ALA A 306
ASP A 309
THR A 310
VAL A 370
LEU A 372
MET A 374
LEU A 477
 HEM  A 601 ( 2.6A)
ASD  A 602 (-4.0A)
None
None
ASD  A 602 ( 4.7A)
HEM  A 601 ( 3.6A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
HEM  A 601 (-4.4A)
None
ASD  A 602 (-4.3A)
ASD  A 602 (-4.5A)
 0.20A 3s79A-4kq8A:
64.5		 3s79A-4kq8A:
92.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kq8 CYTOCHROME P450 19A1

(Homo sapiens) 		PF00067
(p450) 		5 ILE A 305
ALA A 306
ASP A 309
THR A 310
VAL A 369
 ASD  A 602 ( 4.7A)
HEM  A 601 ( 3.6A)
ASD  A 602 (-3.8A)
ASD  A 602 (-3.9A)
None
 1.27A 3s79A-4kq8A:
64.5		 3s79A-4kq8A:
92.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3n S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF09408
(Spike_rec_bind) 		5 ILE A 480
PHE A 571
ILE A 433
LEU A 417
LEU A 414
 None
 1.02A 3s79A-4l3nA:
undetectable		 3s79A-4l3nA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn7 THYMIC STROMAL
LYMPHOPOIETIN

(Mus musculus) 		PF15216
(TSLP) 		5 ILE A  38
TRP A 132
ILE A  30
ALA A  93
LEU A  81
 None
 1.14A 3s79A-4nn7A:
undetectable		 3s79A-4nn7A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		5 ILE A 120
PHE A 166
TRP A 140
ALA A 122
VAL A 177
 None
 1.18A 3s79A-4pu5A:
undetectable		 3s79A-4pu5A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qc6 BIFUNCTIONAL AAC/APH

(Staphylococcus
warneri) 		PF13523
(Acetyltransf_8) 		5 ILE A  70
ILE A 112
VAL A  30
LEU A  25
MET A  21
 None
30N  A 202 (-4.9A)
None
FMT  A 203 ( 4.4A)
None
 0.98A 3s79A-4qc6A:
undetectable		 3s79A-4qc6A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2

(Danio rerio) 		PF00067
(p450) 		5 ALA A 355
ASP A 354
VAL A 454
LEU A 311
LEU A 450
 None
 1.21A 3s79A-4r20A:
38.0		 3s79A-4r20A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9n LMO0547 PROTEIN

(Listeria
monocytogenes) 		PF04198
(Sugar-bind) 		5 ILE A 302
ALA A 279
LEU A 112
MET A 204
LEU A 102
 None
 1.18A 3s79A-4r9nA:
undetectable		 3s79A-4r9nA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 ILE A 156
ILE A 106
ALA A 100
VAL A  76
LEU A  79
 None
 1.29A 3s79A-4roeA:
undetectable		 3s79A-4roeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE

(Haemophilus
influenzae) 		PF00106
(adh_short) 		5 ILE A  95
ILE A  42
ALA A  40
THR A  38
LEU A 256
 None
 1.20A 3s79A-4wuvA:
undetectable		 3s79A-4wuvA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzh DIHYDROOROTATE
DEHYDROGENASE

(Leishmania
braziliensis) 		PF01180
(DHO_dh) 		5 PHE A  96
ILE A 246
ALA A 266
VAL A   5
LEU A   8
 None
None
None
None
EPE  A 402 (-4.7A)
 1.16A 3s79A-4wzhA:
undetectable		 3s79A-4wzhA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)

(Homo sapiens) 		no annotation 5 ILE A 379
ILE A 399
ALA A 371
THR A 369
VAL A 337
 None
None
None
None
GOL  A 501 ( 4.8A)
 1.22A 3s79A-4z79A:
undetectable		 3s79A-4z79A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6d DNA POLYMERASE
SLIDING CLAMP

(Thermococcus
gammatolerans) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ILE A 145
ALA A 205
VAL A  47
LEU A 242
LEU A 227
 None
 1.15A 3s79A-5a6dA:
undetectable		 3s79A-5a6dA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		5 PHE A  97
ILE A 188
ALA A 534
THR A 190
LEU A 171
 None
 1.27A 3s79A-5bptA:
undetectable		 3s79A-5bptA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw4 16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE

(Catenulispora
acidiphila) 		no annotation 5 TRP A  23
ILE A  33
ALA A 104
VAL A  96
LEU A   7
 None
 1.25A 3s79A-5bw4A:
undetectable		 3s79A-5bw4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3i HISTIDINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 ALA A 277
THR A 275
LEU A 153
MET A 157
LEU A 317
 None
 1.25A 3s79A-5e3iA:
undetectable		 3s79A-5e3iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6s AMIDASE

(Microbacterium
sp. HM58-2) 		PF01425
(Amidase) 		5 ILE A 427
ILE A 284
ALA A 282
ASP A 281
LEU A 272
 None
 1.16A 3s79A-5h6sA:
undetectable		 3s79A-5h6sA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmm EXODEOXYRIBONUCLEASE

(Escherichia
virus T5) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		5 ILE A 285
PHE A 281
ALA A 289
THR A  62
MET A 132
 None
 1.24A 3s79A-5hmmA:
undetectable		 3s79A-5hmmA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnp ABC TRANSPORTER

(Raoultella
ornithinolytica) 		PF14524
(Wzt_C) 		5 ILE A 336
PHE A 334
ILE A 304
ALA A 303
ASP A 411
 None
 1.09A 3s79A-5hnpA:
undetectable		 3s79A-5hnpA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j11 THYMIC STROMAL
LYMPHOPOIETIN

(Homo sapiens) 		PF15216
(TSLP) 		5 ILE A  47
TRP A 148
ILE A  39
ALA A 105
LEU A  93
 None
 1.12A 3s79A-5j11A:
undetectable		 3s79A-5j11A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j12 THYMIC STROMAL
LYMPHOPOIETIN

(Homo sapiens) 		PF15216
(TSLP) 		5 ILE A  47
TRP A 148
ILE A  39
ALA A 105
LEU A  93
 None
 1.13A 3s79A-5j12A:
undetectable		 3s79A-5j12A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1b CELL WALL ASSEMBLY
REGULATOR SMI1

(Saccharomyces
cerevisiae) 		PF09346
(SMI1_KNR4) 		5 ILE A 241
PHE A 159
ILE A 277
VAL A 136
LEU A 285
 None
 1.22A 3s79A-5j1bA:
undetectable		 3s79A-5j1bA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgp NITRATE/NITRITE
SENSOR PROTEIN NARQ

(Escherichia
coli) 		PF00672
(HAMP)
PF13675
(PilJ) 		5 PHE A 135
ALA A  40
ASP A  39
VAL A  82
LEU A  86
 None
 1.25A 3s79A-5jgpA:
undetectable		 3s79A-5jgpA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 PHE A 108
ALA A 252
LEU A 211
MET A 124
LEU A 261
 None
 1.24A 3s79A-5keiA:
undetectable		 3s79A-5keiA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		no annotation 5 ILE A 532
ILE A 521
ALA A 520
THR A 517
LEU A 590
 None
 1.24A 3s79A-5nfuA:
undetectable		 3s79A-5nfuA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 PHE B 170
ILE B 186
THR B 106
LEU B 192
LEU B 177
 None
 1.24A 3s79A-5ovnB:
undetectable		 3s79A-5ovnB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrk AP-2 COMPLEX SUBUNIT
MU

(Rattus
norvegicus) 		no annotation 5 ILE A 263
PHE A 265
VAL A 401
MET A 202
LEU A 404
 None
 1.27A 3s79A-5wrkA:
undetectable		 3s79A-5wrkA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 6 ILE A  82
TRP A  85
ALA A 305
THR A 309
VAL A 420
LEU A 430
 None
 1.41A 3s79A-5x7nA:
undetectable		 3s79A-5x7nA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 ILE A1096
PHE A1030
ALA A1087
VAL A1068
LEU A1044
 None
 1.21A 3s79A-5x7sA:
undetectable		 3s79A-5x7sA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 ILE A 403
PHE A 376
LEU A 369
MET A 371
LEU A 384
 None
 1.21A 3s79A-5y3jA:
undetectable		 3s79A-5y3jA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei) 		no annotation 5 ILE A 107
ILE A 255
ALA A 256
THR A 260
VAL A 303
 HEM  A 501 (-4.2A)
None
HEM  A 501 (-3.4A)
HEM  A 501 (-3.7A)
None
 1.02A 3s79A-5ysmA:
29.7		 3s79A-5ysmA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 ILE A 403
PHE A 376
LEU A 369
MET A 371
LEU A 384
 None
 1.19A 3s79A-5zlnA:
undetectable		 3s79A-5zlnA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 5 PHE A 458
ILE A 614
ALA A 610
THR A 607
LEU A 706
 None
 1.16A 3s79A-6aunA:
undetectable		 3s79A-6aunA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwc POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
CAPD

(Bacillus
thuringiensis) 		no annotation 5 ILE A 290
PHE A 283
ILE A 218
ALA A 215
THR A 163
 None
 1.18A 3s79A-6bwcA:
undetectable		 3s79A-6bwcA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 5 ILE P 550
PHE P 554
ILE P 315
VAL P 278
LEU P 352
 None
 1.23A 3s79A-6c1dP:
undetectable		 3s79A-6c1dP:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbc -

(-) 		no annotation 5 ILE A 253
ASP A 216
THR A 217
LEU A 303
LEU A 175
 None
 1.01A 3s79A-6cbcA:
undetectable		 3s79A-6cbcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 5 ILE A 455
ILE A 473
ALA A 474
VAL A 481
LEU A 429
 None
 1.14A 3s79A-6cczA:
undetectable		 3s79A-6cczA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fea NITROGENASE PROTEIN
ALPHA CHAIN

(Azotobacter
vinelandii) 		no annotation 5 ASP A 320
VAL A 437
LEU A 439
MET A 443
LEU A 351
 None
 1.21A 3s79A-6feaA:
undetectable		 3s79A-6feaA:
11.54