SIMILAR PATTERNS OF AMINO ACIDS FOR 3S53_A_017A201
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aip | ELONGATION FACTOR TS (Thermusthermophilus) |
PF00889(EF_TS) | 5 | GLY C 15ALA C 16ASP C 20GLY C 181ILE C 180 | None | 0.99A | 3s53A-1aipC:undetectable | 3s53A-1aipC:18.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bkb | TRANSLATIONINITIATION FACTOR 5A (Pyrobaculumaerophilum) |
PF01287(eIF-5a)PF08207(EFP_N) | 5 | ALA A 81ASP A 95ILE A 102ILE A 135ILE A 91 | None | 0.86A | 3s53A-1bkbA:undetectable | 3s53A-1bkbA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bxz | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 6 | GLY A 211ALA A 212ASP A 214ILE A 195GLY A 192ILE A 240 | None | 1.17A | 3s53A-1bxzA:undetectable | 3s53A-1bxzA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3r | HDLP (HISTONEDEACETYLASE-LIKEPROTEIN) (Aquifexaeolicus) |
PF00850(Hist_deacetyl) | 5 | ASP A 168ASP A 166ILE A 165ILE A 309ILE A 281 | ZN A 501 ( 2.3A)NoneNoneNoneNone | 1.01A | 3s53A-1c3rA:undetectable | 3s53A-1c3rA:13.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e19 | CARBAMATE KINASE (Pyrococcusfuriosus) |
PF00696(AA_kinase) | 5 | GLY A 194ILE A 114GLY A 90ILE A 93ILE A 179 | None | 0.97A | 3s53A-1e19A:undetectable | 3s53A-1e19A:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ghh | DNA-DAMAGE-INDUCIBLEPROTEIN I (Escherichiacoli) |
PF06183(DinI) | 5 | GLY A 54ALA A 55ASP A 59ILE A 63GLY A 38 | None | 0.95A | 3s53A-1ghhA:undetectable | 3s53A-1ghhA:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3g | CYCLOMALTODEXTRINASE (Flavobacteriumsp. 92) |
PF00128(Alpha-amylase)PF09087(Cyc-maltodext_N)PF10438(Cyc-maltodext_C) | 5 | ASP A 115GLY A 144ASP A 146ILE A 112GLY A 476 | None CA A 700 (-3.9A) CA A 700 (-3.2A)NoneNone | 1.01A | 3s53A-1h3gA:undetectable | 3s53A-1h3gA:9.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 29ASP A 30GLY A 48 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 ( 4.7A)A79 A 800 (-4.1A) | 0.79A | 3s53A-1hvcA:13.1 | 3s53A-1hvcA:45.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 48 | A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 4.9A)A79 A 800 (-3.6A) | 0.80A | 3s53A-1hvcA:13.1 | 3s53A-1hvcA:45.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50 | A79 A 800 (-2.7A)A79 A 800 (-3.0A)A79 A 800 (-3.1A)A79 A 800 (-2.8A)A79 A 800 ( 4.9A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A) | 0.46A | 3s53A-1hvcA:13.1 | 3s53A-1hvcA:45.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50 | A79 A 800 (-2.8A)A79 A 800 (-3.0A)A79 A 800 (-3.2A)A79 A 800 (-2.7A)A79 A 800 ( 4.7A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A) | 0.47A | 3s53A-1hvcA:13.1 | 3s53A-1hvcA:45.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqb | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A1211ALA A1212ASP A1214GLY A1192ILE A1240 | None | 0.95A | 3s53A-1jqbA:undetectable | 3s53A-1jqbA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ldn | L-LACTATEDEHYDROGENASE (Geobacillusstearothermophilus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ASP A 46GLY A 20ALA A 21ASP A 90ILE A 44 | None | 0.99A | 3s53A-1ldnA:undetectable | 3s53A-1ldnA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nnl | L-3-PHOSPHOSERINEPHOSPHATASE (Homo sapiens) |
PF00702(Hydrolase) | 5 | GLY A 180ASP A 20ILE A 194GLY A 197ILE A 201 | None CA A2001 (-2.3A)NoneNoneNone | 0.92A | 3s53A-1nnlA:undetectable | 3s53A-1nnlA:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nnt | OVOTRANSFERRIN (Gallus gallus) |
PF00405(Transferrin) | 5 | GLY A 68ALA A 67ILE A 57GLY A 61ILE A 77 | None | 0.91A | 3s53A-1nntA:undetectable | 3s53A-1nntA:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pfx | FACTOR IXA (Sus scrofa) |
PF00008(EGF)PF00594(Gla)PF14670(FXa_inhibition) | 5 | GLY L 76ALA L 86ASP L 85ILE L 90GLY L 79 | None | 0.93A | 3s53A-1pfxL:undetectable | 3s53A-1pfxL:15.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1q9p | HIV-1 PROTEASE (Homo sapiens) |
PF00077(RVP) | 5 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30 | None | 0.47A | 3s53A-1q9pA:9.6 | 3s53A-1q9pA:96.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 29GLY A 49ILE A 50ILE A 82 | None | 1.31A | 3s53A-1sivA:17.7 | 3s53A-1sivA:53.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 9 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32GLY A 49ILE A 50ILE A 82 | None | 0.55A | 3s53A-1sivA:17.7 | 3s53A-1sivA:53.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29ILE A 32GLY A 48ILE A 82 | None | 0.78A | 3s53A-1sivA:17.7 | 3s53A-1sivA:53.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1svv | THREONINE ALDOLASE (Leishmaniamajor) |
PF01212(Beta_elim_lyase) | 6 | ASP A 183GLY A 184ALA A 185GLY A 74ILE A 72ILE A 101 | None | 1.05A | 3s53A-1svvA:undetectable | 3s53A-1svvA:14.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to6 | GLYCERATE KINASE (Neisseriameningitidis) |
PF02595(Gly_kinase) | 5 | GLY A 244ALA A 243ILE A 259GLY A 250ILE A 143 | SO4 A 373 (-3.5A)SO4 A 373 ( 4.2A)NoneNoneNone | 0.86A | 3s53A-1to6A:undetectable | 3s53A-1to6A:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v9l | GLUTAMATEDEHYDROGENASE (Pyrobaculumislandicum) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | GLY A 320ALA A 321ILE A 300GLY A 217ILE A 304 | NoneNAD A 430 (-3.8A)NAD A 430 (-4.2A)NAD A 430 (-3.5A)None | 1.01A | 3s53A-1v9lA:undetectable | 3s53A-1v9lA:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vft | ALANINE RACEMASE (Streptomyceslavendulae) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | GLY A 340ASP A 13ILE A 12GLY A 231ILE A 367 | None | 1.01A | 3s53A-1vftA:undetectable | 3s53A-1vftA:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xn9 | 30S RIBOSOMALPROTEIN S24E (Methanosarcinamazei) |
PF01282(Ribosomal_S24e) | 5 | ASP A 20ASP A 8ILE A 5ILE A 52ILE A 22 | None | 1.01A | 3s53A-1xn9A:undetectable | 3s53A-1xn9A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dws | COPPER-CONTAININGNITRITE REDUCTASE (Rhodobactersphaeroides) |
PF00394(Cu-oxidase)PF07732(Cu-oxidase_3) | 5 | GLY A 254ALA A 255GLY A 347ILE A 250ILE A 217 | None | 0.91A | 3s53A-2dwsA:undetectable | 3s53A-2dwsA:16.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 5 | ASP A 25GLY A 27ALA A 28ASP A 29GLY A 54 | LP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)LP1 A 201 (-3.6A) | 0.76A | 3s53A-2fmbA:14.9 | 3s53A-2fmbA:30.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 5 | ASP A 25GLY A 27ALA A 28ASP A 29GLY A 55 | LP1 A 201 (-2.3A)LP1 A 201 (-3.8A)LP1 A 201 (-3.5A)LP1 A 201 (-3.6A)LP1 A 201 (-3.4A) | 0.21A | 3s53A-2fmbA:14.9 | 3s53A-2fmbA:30.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j87 | THYMIDINE KINASE (Vaccinia virus) |
PF00265(TK) | 5 | GLY A 84ASP A 82ILE A 105ILE A 10ILE A 6 | NoneTTP A 300 (-3.0A)NoneNoneNone | 0.90A | 3s53A-2j87A:undetectable | 3s53A-2j87A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m60 | ENTEROCIN JSB (Enterococcusfaecalis) |
no annotation | 5 | GLY A 2ALA A 3ILE A 36GLY A 28ILE A 16 | None | 0.87A | 3s53A-2m60A:undetectable | 3s53A-2m60A:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pa6 | ENOLASE (Methanocaldococcusjannaschii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | GLY A 177ALA A 178ILE A 181GLY A 188ILE A 173 | None | 0.94A | 3s53A-2pa6A:undetectable | 3s53A-2pa6A:10.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ph5 | HOMOSPERMIDINESYNTHASE (Legionellapneumophila) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 5 | GLY A 107ALA A 108ASP A 85GLY A 78ILE A 100 | None | 1.00A | 3s53A-2ph5A:undetectable | 3s53A-2ph5A:12.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qde | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Aromatoleumaromaticum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ASP A 175GLY A 169ALA A 168ILE A 220GLY A 198 | None | 0.98A | 3s53A-2qdeA:undetectable | 3s53A-2qdeA:14.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32GLY A 49ILE A 50 | AB1 A 501 (-2.4A)AB1 A 501 (-3.9A)AB1 A 501 (-3.5A)AB1 A 501 ( 3.3A)AB1 A 501 (-3.8A)AB1 A 501 (-4.5A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A) | 0.33A | 3s53A-2rkfA:19.5 | 3s53A-2rkfA:84.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32GLY A 48 | AB1 A 501 (-3.9A)AB1 A 501 (-3.5A)AB1 A 501 ( 3.3A)AB1 A 501 (-3.8A)AB1 A 501 (-4.5A)AB1 A 501 (-4.2A) | 0.82A | 3s53A-2rkfA:19.5 | 3s53A-2rkfA:84.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rsp | RSV PROTEASE (Rous sarcomavirus) |
PF00077(RVP) | 5 | ASP A 37GLY A 39ALA A 40ASP A 41ILE A 44 | None | 0.24A | 3s53A-2rspA:12.7 | 3s53A-2rspA:33.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bc8 | O-PHOSPHOSERYL-TRNA(SEC) SELENIUMTRANSFERASE (Mus musculus) |
PF05889(SepSecS) | 5 | ASP A 62GLY A 110GLY A 96ILE A 95ILE A 92 | None | 0.99A | 3s53A-3bc8A:undetectable | 3s53A-3bc8A:12.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c8t | FUMARATE LYASE (Chelativoranssp. BNC1) |
PF00206(Lyase_1)PF10397(ADSL_C) | 5 | GLY A 341ALA A 343ASP A 27GLY A 132ILE A 129 | None | 0.93A | 3s53A-3c8tA:undetectable | 3s53A-3c8tA:11.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dh0 | SAM DEPENDENTMETHYLTRANSFERASE (Aquifexaeolicus) |
PF13847(Methyltransf_31) | 5 | GLY A 172ALA A 171ASP A 170GLY A 165ILE A 110 | None | 1.01A | 3s53A-3dh0A:undetectable | 3s53A-3dh0A:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fpl | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii;Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 211ALA A 212ASP A 214GLY A 192ILE A 240 | None | 0.95A | 3s53A-3fplA:undetectable | 3s53A-3fplA:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fsr | NADP-DEPENDENTALCOHOLDEHYDROGENASE (Clostridiumbeijerinckii;Thermoanaerobacterbrockii) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 211ALA A 212ASP A 214GLY A 192ILE A 240 | None | 0.90A | 3s53A-3fsrA:undetectable | 3s53A-3fsrA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0g | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB2 (Schizosaccharomycespombe) |
PF00562(RNA_pol_Rpb2_6)PF00623(RNA_pol_Rpb1_2)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | GLY B 977ASP A 489ASP A 491ILE A 359ILE B 965 | None | 1.01A | 3s53A-3h0gB:undetectable | 3s53A-3h0gB:5.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3huu | TRANSCRIPTIONREGULATOR LIKEPROTEIN (Staphylococcushaemolyticus) |
PF13377(Peripla_BP_3) | 5 | GLY A 84ILE A 120GLY A 263ILE A 47ILE A 109 | None | 0.98A | 3s53A-3huuA:undetectable | 3s53A-3huuA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i5g | MYOSIN HEAVY CHAINISOFORM A (Doryteuthispealeii) |
PF00063(Myosin_head)PF00612(IQ)PF02736(Myosin_N) | 5 | GLY A 264ALA A 265ASP A 266GLY A 460ILE A 459 | None | 0.74A | 3s53A-3i5gA:undetectable | 3s53A-3i5gA:7.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mmp | ELONGATION FACTOR TU2, ELONGATION FACTORTS (Escherichiacoli) |
PF00009(GTP_EFTU)PF00889(EF_TS)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 5 | GLY A 16ALA A 17ASP A 21GLY A 126ILE A 125 | None | 0.93A | 3s53A-3mmpA:undetectable | 3s53A-3mmpA:10.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mru | AMINOACYL-HISTIDINEDIPEPTIDASE (Vibrioalginolyticus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | GLY A 121ALA A 118ASP A 119GLY A 454ILE A 469 | NoneNone ZN A 492 ( 2.4A)NoneNone | 0.89A | 3s53A-3mruA:undetectable | 3s53A-3mruA:12.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 48 | None | 0.72A | 3s53A-3mwsA:18.7 | 3s53A-3mwsA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ALA A 28ASP A 29GLY A 49ILE A 50 | None | 0.29A | 3s53A-3mwsA:18.7 | 3s53A-3mwsA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n05 | NH(3)-DEPENDENTNAD(+) SYNTHETASE (Streptomycesavermitilis) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 5 | GLY A 432ILE A 329GLY A 334ILE A 335ILE A 343 | None | 0.87A | 3s53A-3n05A:undetectable | 3s53A-3n05A:9.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p4g | ANTIFREEZE PROTEIN (Marinomonasprimoryensis) |
no annotation | 5 | ASP A 122GLY A 118ALA A 117ILE A 143GLY A 156 | CA A 404 ( 2.4A) CA A 404 (-4.1A) CA A 405 (-4.7A)None CA A 406 (-4.0A) | 0.97A | 3s53A-3p4gA:undetectable | 3s53A-3p4gA:14.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk8 | ENOYL-COA HYDRATASEECHA15 (Mycobacteriummarinum) |
PF00378(ECH_1) | 5 | GLY A 118ALA A 117ILE A 75GLY A 139ILE A 137 | NoneUNL A 291 ( 3.3A)NoneNoneNone | 0.91A | 3s53A-3qk8A:undetectable | 3s53A-3qk8A:18.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50 | 017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-3.5A)017 A 201 (-3.5A)017 A 201 (-4.2A)017 A 201 (-4.0A)017 A 201 (-3.3A) | 0.24A | 3s53A-3t3cA:17.8 | 3s53A-3t3cA:72.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tkt | CYTOCHROME P450 (Novosphingobiumaromaticivorans) |
PF00067(p450) | 5 | GLY A 227ALA A 229ILE A 244GLY A 173ILE A 264 | None | 0.95A | 3s53A-3tktA:undetectable | 3s53A-3tktA:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqp | ENOLASE (Coxiellaburnetii) |
PF00113(Enolase_C)PF03952(Enolase_N) | 6 | ALA A 245ASP A 244ILE A 284GLY A 311ILE A 314ILE A 269 | None MG A 430 (-2.8A)NoneNoneNoneNone | 1.35A | 3s53A-3tqpA:undetectable | 3s53A-3tqpA:15.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32GLY A 49ILE A 50 | 017 A 201 (-2.6A)017 A 201 (-3.6A)017 A 201 (-3.4A)017 A 201 (-3.3A)017 A 201 (-4.6A)None017 A 201 (-3.0A)017 A 201 (-3.3A) | 0.49A | 3s53A-3ttpA:18.6 | 3s53A-3ttpA:78.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32GLY A 48 | 017 A 201 (-3.6A)017 A 201 (-3.4A)017 A 201 (-3.3A)017 A 201 (-4.6A)NoneNone | 0.78A | 3s53A-3ttpA:18.6 | 3s53A-3ttpA:78.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ALA A 28ASP A 29ASP A 30ILE A 32GLY A 48 | 017 A 201 (-3.4A)017 A 201 (-3.2A)017 A 201 ( 4.0A)None017 A 202 ( 4.6A) | 0.77A | 3s53A-3u7sA:18.6 | 3s53A-3u7sA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32GLY A 49ILE A 50 | 017 A 202 ( 2.5A)017 A 201 ( 3.5A)017 A 201 (-3.4A)017 A 201 (-3.2A)017 A 201 ( 4.0A)None017 A 202 (-2.9A)017 A 201 ( 3.5A) | 0.33A | 3s53A-3u7sA:18.6 | 3s53A-3u7sA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uhl | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25GLY A 27ALA A 28ASP A 29ILE A 32 | None | 0.23A | 3s53A-3uhlA:15.5 | 3s53A-3uhlA:81.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wd8 | TYPE III POLYKETIDESYNTHASE QUINOLONESYNTHASE (Citrus xmicrocarpa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | ALA A 131ASP A 192ILE A 193GLY A 106ILE A 99 | None | 0.99A | 3s53A-3wd8A:undetectable | 3s53A-3wd8A:12.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5o | BIFUNCTIONAL PROTEINFOLD (Pseudomonasaeruginosa) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | ALA A 162ASP A 161ASP A 204GLY A 183ILE A 146 | None | 0.96A | 3s53A-4a5oA:undetectable | 3s53A-4a5oA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bk1 | PROBABLE SALICYLATEMONOOXYGENASE (Rhodococcusjostii) |
PF01494(FAD_binding_3) | 6 | GLY A 209ALA A 82ASP A 81GLY A 206ILE A 215ILE A 264 | NoneNoneNoneP3A A1399 ( 4.6A)P3A A1399 (-4.4A)None | 1.40A | 3s53A-4bk1A:undetectable | 3s53A-4bk1A:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4db5 | TUMOR NECROSISFACTOR LIGANDSUPERFAMILY MEMBER18 (Oryctolaguscuniculus) |
no annotation | 5 | GLY A 41ASP A 91ASP A 94ILE A 96ILE A 87 | NoneB3P A 201 (-4.9A)NoneNoneNone | 0.92A | 3s53A-4db5A:undetectable | 3s53A-4db5A:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f0j | PROBABLE HYDROLYTICENZYME (Pseudomonasaeruginosa) |
PF00561(Abhydrolase_1) | 6 | GLY A 93ALA A 90ASP A 91ASP A 87ILE A 86ILE A 97 | None | 1.30A | 3s53A-4f0jA:undetectable | 3s53A-4f0jA:15.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fsf | PENICILLIN-BINDINGPROTEIN 3 (Pseudomonasaeruginosa) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | GLY A 382ILE A 287GLY A 177ILE A 178ILE A 416 | None | 0.99A | 3s53A-4fsfA:undetectable | 3s53A-4fsfA:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h1s | 5'-NUCLEOTIDASE (Homo sapiens) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 5 | GLY A 89ASP A 121GLY A 393ILE A 394ILE A 525 | None | 0.93A | 3s53A-4h1sA:undetectable | 3s53A-4h1sA:10.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jip | GTN REDUCTASE (Agrobacteriumtumefaciens) |
PF00724(Oxidored_FMN) | 5 | GLY A 223ALA A 224GLY A 11ILE A 13ILE A 229 | None | 0.94A | 3s53A-4jipA:undetectable | 3s53A-4jipA:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kt7 | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATECYTIDYLYLTRANSFERASE (Anaerococcusprevotii) |
PF01128(IspD) | 6 | GLY A 108ALA A 13ASP A 61ILE A 65ILE A 39ILE A 76 | None | 1.48A | 3s53A-4kt7A:undetectable | 3s53A-4kt7A:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgv | GLUCOSE-6-PHOSPHATE1-DEHYDROGENASE (Mycobacteriumavium) |
PF00479(G6PD_N)PF02781(G6PD_C) | 5 | GLY A 88ASP A 49ILE A 51GLY A 45ILE A 44 | None | 0.98A | 3s53A-4lgvA:undetectable | 3s53A-4lgvA:11.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 48 | RIT A 500 (-2.4A)RIT A 500 (-3.9A)RIT A 500 (-3.6A)RIT A 500 (-3.2A)RIT A 500 (-4.8A)RIT A 500 (-4.8A) | 0.70A | 3s53A-4njvA:18.5 | 3s53A-4njvA:82.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25GLY A 27ALA A 28ASP A 29GLY A 49ILE A 50 | RIT A 500 (-2.4A)RIT A 500 (-3.9A)RIT A 500 (-3.6A)RIT A 500 (-3.2A)RIT A 500 (-3.4A)RIT A 500 (-4.3A) | 0.46A | 3s53A-4njvA:18.5 | 3s53A-4njvA:82.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qnw | CHANOCLAVINE-IALDEHYDE REDUCTASE (Aspergillusfumigatus) |
PF00724(Oxidored_FMN) | 5 | GLY A 218ALA A 219ASP A 256GLY A 17ILE A 172 | None | 0.98A | 3s53A-4qnwA:undetectable | 3s53A-4qnwA:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qnx | TRNA(MO5U34)-METHYLTRANSFERASE (Escherichiacoli) |
PF08003(Methyltransf_9) | 5 | ASP A 152GLY A 132ASP A 128ILE A 181GLY A 197 | NoneNoneNoneSO4 A 402 (-4.0A)SO4 A 401 (-3.3A) | 0.93A | 3s53A-4qnxA:undetectable | 3s53A-4qnxA:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rgh | PROTEIN DDI1 HOMOLOG2 (Homo sapiens) |
PF09668(Asp_protease) | 5 | ASP A 220GLY A 222ALA A 223ILE A 227GLY A 252 | None | 0.82A | 3s53A-4rghA:10.4 | 3s53A-4rghA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqk | LECTIN 2 (Agrocybeaegerita) |
PF13517(VCBS) | 5 | ASP A 179ASP A 187ILE A 198GLY A 260ILE A 214 | None | 0.92A | 3s53A-4tqkA:undetectable | 3s53A-4tqkA:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqk | LECTIN 2 (Agrocybeaegerita) |
PF13517(VCBS) | 5 | ASP A 290GLY A 295ASP A 235ILE A 288GLY A 316 | None | 0.84A | 3s53A-4tqkA:undetectable | 3s53A-4tqkA:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ttp | DEPHOSPHO-COA KINASE (Legionellapneumophila) |
PF01121(CoaE) | 5 | ALA A 175ASP A 176ASP A 177GLY A 12ILE A 118 | None | 0.89A | 3s53A-4ttpA:undetectable | 3s53A-4ttpA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ud8 | FAD-BINDING AND BBEDOMAIN-CONTAININGPROTEIN (Arabidopsisthaliana) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | GLY A 191ALA A 192ILE A 158GLY A 185ILE A 244 | NoneFAD A 601 (-4.3A)NoneFAD A 601 (-3.6A)FAD A 601 (-3.8A) | 0.90A | 3s53A-4ud8A:undetectable | 3s53A-4ud8A:12.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | ASP A 32GLY A 34ALA A 35ASP A 36GLY A 58 | 4B1 A 201 (-2.9A)4B1 A 201 ( 4.6A)4B1 A 201 (-3.6A)4B1 A 201 (-4.4A)4B1 A 201 (-3.4A) | 0.39A | 3s53A-4ydfA:12.5 | 3s53A-4ydfA:33.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynn | PROTEASE DO (Legionellapneumophila) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | GLY A 377ASP A 393ILE A 395GLY A 384ILE A 406 | None | 0.91A | 3s53A-4ynnA:undetectable | 3s53A-4ynnA:13.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49 | None | 0.61A | 3s53A-5b18A:16.9 | 3s53A-5b18A:75.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b18 | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32 | None | 0.33A | 3s53A-5b18A:16.9 | 3s53A-5b18A:75.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c9d | APRICK PROTEASE (Rickettsiaconorii) |
PF13975(gag-asp_proteas) | 5 | ASP A 140GLY A 142ALA A 143ASP A 145ILE A 206 | None | 0.77A | 3s53A-5c9dA:8.6 | 3s53A-5c9dA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5doo | PROTEIN LYSINEMETHYLTRANSFERASE 2 (Rickettsiatyphi) |
PF10119(MethyTransf_Reg)PF13847(Methyltransf_31) | 5 | ASP A 74GLY A 53ASP A 49ILE A 102GLY A 119 | None | 0.89A | 3s53A-5dooA:undetectable | 3s53A-5dooA:12.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME SUBUNITBETA TYPE (Plasmodiumfalciparum) |
PF00227(Proteasome) | 5 | GLY N 117ILE N 176GLY N 53ILE N 43ILE N 15 | None | 0.83A | 3s53A-5fmgN:undetectable | 3s53A-5fmgN:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fux | THYMDINE KINASE (Trypanosomabrucei) |
PF00265(TK) | 5 | GLY A 287ASP A 285ILE A 308ILE A 211ILE A 207 | None MG A1385 ( 4.3A)NoneNoneNone | 0.91A | 3s53A-5fuxA:undetectable | 3s53A-5fuxA:18.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j90 | RAGB/SUSD DOMAINPROTEIN (Flavobacteriumjohnsoniae) |
PF12741(SusD-like) | 5 | ASP A 76GLY A 450ILE A 336ILE A 345ILE A 276 | None | 0.95A | 3s53A-5j90A:undetectable | 3s53A-5j90A:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j90 | RAGB/SUSD DOMAINPROTEIN (Flavobacteriumjohnsoniae) |
PF12741(SusD-like) | 5 | GLY A 446ALA A 445ILE A 379ILE A 292ILE A 438 | None | 0.90A | 3s53A-5j90A:undetectable | 3s53A-5j90A:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzm | TRYPTOPHAN SYNTHASEALPHA CHAIN (Francisellatularensis) |
PF00290(Trp_syntA) | 5 | GLY A 123ALA A 122ASP A 121ILE A 127ILE A 26 | None | 0.97A | 3s53A-5kzmA:undetectable | 3s53A-5kzmA:17.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ldn | HEXON PROTEIN,HEXONCAPSID (HumanmastadenovirusC) |
PF01065(Adeno_hexon)PF03678(Adeno_hexon_C) | 5 | GLY A 220ALA A 171ILE A 215GLY A 206ILE A 205 | None | 0.78A | 3s53A-5ldnA:undetectable | 3s53A-5ldnA:7.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m6p | TYROCIDINE SYNTHASE2 (Brevibacillusparabrevis) |
no annotation | 5 | GLY A3377ALA A3379ASP A3382ILE A3553ILE A3525 | None | 0.91A | 3s53A-5m6pA:undetectable | 3s53A-5m6pA:14.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpd | 26S PROTEASOMEREGULATORY SUBUNITRPN2 (Saccharomycescerevisiae) |
PF01851(PC_rep)PF13646(HEAT_2) | 5 | GLY N 698ALA N 699GLY N 704ILE N 705ILE N 678 | None | 0.94A | 3s53A-5mpdN:undetectable | 3s53A-5mpdN:6.34 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30GLY A 49ILE A 50 | None | 0.42A | 3s53A-5t2zA:19.6 | 3s53A-5t2zA:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1a | MYOSIN HEAVY CHAIN,MUSCLE (Drosophilamelanogaster) |
no annotation | 5 | GLY A 259ALA A 260ASP A 261GLY A 457ILE A 456 | None | 0.92A | 3s53A-5w1aA:undetectable | 3s53A-5w1aA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp5 | PHOSPHOMETHYLETHANOLAMINEN-METHYLTRANSFERASE2 (Arabidopsisthaliana) |
no annotation | 5 | GLY A 422ASP A 424ASP A 425GLY A 379ILE A 383 | None | 0.91A | 3s53A-5wp5A:undetectable | 3s53A-5wp5A:12.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yrx | NUCLEOID-ASSOCIATEDPROTEIN RV3716C (Mycobacteriumtuberculosis) |
no annotation | 5 | GLY A 76ALA A 77ASP A 80GLY A 39ILE A 57 | None | 0.97A | 3s53A-5yrxA:undetectable | 3s53A-5yrxA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fiv | RETROPEPSIN (Felineimmunodeficiencyvirus) |
PF00077(RVP) | 6 | ASP A 30GLY A 32ALA A 33ASP A 34ILE A 37GLY A 58 | 3TL A 201 (-3.5A)3TL A 201 (-3.4A)3TL A 201 (-4.0A)3TL A 201 (-3.9A)3TL A 201 ( 4.8A)3TL A 201 (-3.4A) | 0.38A | 3s53A-6fivA:15.2 | 3s53A-6fivA:29.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 7 | ASP A 25ALA A 28ASP A 29ASP A 30ILE A 32GLY A 48ILE A 82 | NIU A 100 (-2.8A)NIU A 100 (-3.6A)NoneNoneNoneNoneNIU A 100 (-4.6A) | 0.98A | 3s53A-6upjA:16.9 | 3s53A-6upjA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 8 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32GLY A 49ILE A 50 | NIU A 100 (-2.8A)NIU A 100 (-4.5A)NIU A 100 (-3.6A)NoneNoneNoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A) | 0.79A | 3s53A-6upjA:16.9 | 3s53A-6upjA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 7 | ASP A 25GLY A 27ALA A 28ASP A 29ASP A 30ILE A 32ILE A 82 | NIU A 100 (-2.8A)NIU A 100 (-4.5A)NIU A 100 (-3.6A)NoneNoneNoneNIU A 100 (-4.6A) | 0.53A | 3s53A-6upjA:16.9 | 3s53A-6upjA:52.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bou | 4,5-DIOXYGENASE BETACHAIN (Sphingomonaspaucimobilis) |
PF02900(LigB) | 5 | LEU B 102ALA B 175GLY B 169ILE B 148ILE B 106 | None | 0.85A | 3s53B-1bouB:undetectable | 3s53B-1bouB:14.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28ASP A 30ILE A 50PRO A 81ILE A 84 | A79 A 800 ( 3.8A)A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 ( 4.9A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-3.6A) | 0.57A | 3s53B-1hvcA:14.1 | 3s53B-1hvcA:45.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28ASP A 30ILE A 50PRO A 81ILE A 84 | A79 A 800 ( 4.0A)A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 ( 4.7A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.54A | 3s53B-1hvcA:14.1 | 3s53B-1hvcA:45.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 ( 3.8A)A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-3.6A) | 0.43A | 3s53B-1hvcA:14.1 | 3s53B-1hvcA:45.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 ( 4.0A)A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.39A | 3s53B-1hvcA:14.1 | 3s53B-1hvcA:45.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j33 | COBT (Thermusthermophilus) |
PF02277(DBI_PRT) | 5 | LEU A 230ALA A 52ILE A 236GLY A 305ILE A 233 | None | 1.12A | 3s53B-1j33A:undetectable | 3s53B-1j33A:14.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rt8 | FIMBRIN (Schizosaccharomycespombe) |
PF00307(CH) | 5 | LEU A 158ASP A 161ASP A 165GLY A 235ILE A 228 | None | 1.01A | 3s53B-1rt8A:undetectable | 3s53B-1rt8A:11.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 6 | ALA A 28ILE A 32GLY A 48PRO A 81ILE A 82ILE A 84 | None | 0.79A | 3s53B-1sivA:18.2 | 3s53B-1sivA:53.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 9 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 30ILE A 32PRO A 81ILE A 82ILE A 84 | None | 0.63A | 3s53B-1sivA:18.2 | 3s53B-1sivA:53.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 9 | ARG A 8LEU A 23ASP A 25ALA A 28ILE A 32GLY A 49PRO A 81ILE A 82ILE A 84 | None | 0.48A | 3s53B-1sivA:18.2 | 3s53B-1sivA:53.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ARG A 8LEU A 23ASP A 29PRO A 81ILE A 82 | None | 0.85A | 3s53B-1sivA:18.2 | 3s53B-1sivA:53.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 9 | LEU A 23ASP A 25ALA A 28ASP A 30ILE A 32ILE A 50PRO A 81ILE A 82ILE A 84 | None | 0.63A | 3s53B-1sivA:18.2 | 3s53B-1sivA:53.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 9 | LEU A 23ASP A 25ALA A 28ILE A 32GLY A 49ILE A 50PRO A 81ILE A 82ILE A 84 | None | 0.44A | 3s53B-1sivA:18.2 | 3s53B-1sivA:53.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tke | THREONYL-TRNASYNTHETASE (Escherichiacoli) |
PF02824(TGS)PF07973(tRNA_SAD) | 5 | ALA A 24ASP A 22GLY A 38ILE A 60PRO A 7 | None | 1.18A | 3s53B-1tkeA:undetectable | 3s53B-1tkeA:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w78 | FOLC BIFUNCTIONALPROTEIN (Escherichiacoli) |
PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | ASP A 172ILE A 184GLY A 151ILE A 191ILE A 169 | MG A1422 ( 4.8A)KCX A 188 ( 4.9A)KCX A 188 ( 4.1A)KCX A 188 ( 3.9A)None | 1.00A | 3s53B-1w78A:undetectable | 3s53B-1w78A:14.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ani | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASEBETA SUBUNIT (Chlamydiatrachomatis) |
PF00268(Ribonuc_red_sm) | 5 | LEU A 305GLY A 194ILE A 195ILE A 257ILE A 303 | None | 1.14A | 3s53B-2aniA:undetectable | 3s53B-2aniA:13.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bty | ACETYLGLUTAMATEKINASE (Thermotogamaritima) |
PF00696(AA_kinase) | 5 | ILE A 165GLY A 169ILE A 170ILE A 152ILE A 120 | None | 0.87A | 3s53B-2btyA:undetectable | 3s53B-2btyA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f31 | DIAPHANOUS PROTEINHOMOLOG 1 (Mus musculus) |
PF06367(Drf_FH3)PF06371(Drf_GBD) | 5 | ALA A 238ILE A 208GLY A 231ILE A 232ILE A 209 | None | 0.95A | 3s53B-2f31A:undetectable | 3s53B-2f31A:17.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 6 | LEU A 23ASP A 25ALA A 28GLY A 55PRO A 86ILE A 89 | NoneLP1 A 201 (-2.3A)LP1 A 201 (-3.5A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.26A | 3s53B-2fmbA:15.0 | 3s53B-2fmbA:30.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j5b | TYROSYL-TRNASYNTHETASE (Acanthamoebapolyphagamimivirus) |
PF00579(tRNA-synt_1b) | 5 | LEU A 49ILE A 232ILE A 263ILE A 310ILE A 45 | LEU A 49 ( 0.6A)ILE A 232 ( 0.7A)ILE A 263 ( 0.7A)ILE A 310 ( 0.7A)ILE A 45 ( 0.7A) | 1.06A | 3s53B-2j5bA:undetectable | 3s53B-2j5bA:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nv0 | GLUTAMINEAMIDOTRANSFERASESUBUNIT PDXT (Bacillussubtilis) |
PF01174(SNO) | 5 | ARG A 66LEU A 97ILE A 83PRO A 95ILE A 84 | None | 1.01A | 3s53B-2nv0A:undetectable | 3s53B-2nv0A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q27 | OXALYL-COADECARBOXYLASE (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | LEU A 505ILE A 460GLY A 426ILE A 537ILE A 457 | None | 0.79A | 3s53B-2q27A:undetectable | 3s53B-2q27A:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qv6 | GTP CYCLOHYDROLASEIII (Methanocaldococcusjannaschii) |
PF05165(GCH_III) | 5 | LEU A 212ILE A 142GLY A 181ILE A 180ILE A 139 | NoneGTP A 300 (-4.1A)GTP A 300 ( 4.8A)GTP A 300 (-3.8A)None | 1.00A | 3s53B-2qv6A:undetectable | 3s53B-2qv6A:18.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28ASP A 30ILE A 32PRO A 81ILE A 84 | NoneAB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.5A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.60A | 3s53B-2rkfA:20.7 | 3s53B-2rkfA:84.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25ALA A 28ILE A 32GLY A 49ILE A 50PRO A 81ILE A 84 | NoneAB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-4.5A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.48A | 3s53B-2rkfA:20.7 | 3s53B-2rkfA:84.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rsp | RSV PROTEASE (Rous sarcomavirus) |
PF00077(RVP) | 6 | ARG A 10LEU A 35ASP A 37ALA A 40ILE A 44ILE A 108 | None | 0.87A | 3s53B-2rspA:12.6 | 3s53B-2rspA:33.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xi7 | RNA POLYMERASE L (Californiaencephalitisorthobunyavirus) |
PF15518(L_protein_N) | 5 | LEU A 88ASP A 79ILE A 56ILE A 124ILE A 90 | None MN A1184 (-2.6A)NoneNoneNone | 1.10A | 3s53B-2xi7A:undetectable | 3s53B-2xi7A:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e82 | PUTATIVEOXIDOREDUCTASE (Klebsiellapneumoniae) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | LEU A 91ALA A 47GLY A 24ILE A 81ILE A 21 | None | 1.19A | 3s53B-3e82A:undetectable | 3s53B-3e82A:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gzr | UNCHARACTERIZEDPROTEIN WITH ANTF2-LIKE FOLD (Caulobactervibrioides) |
PF14534(DUF4440) | 5 | ARG A 104ALA A 141ILE A 40GLY A 153ILE A 36 | None | 1.07A | 3s53B-3gzrA:undetectable | 3s53B-3gzrA:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k1n | HTH-TYPETRANSCRIPTIONALREGULATOR BENM (Acinetobactersp. ADP1) |
PF00126(HTH_1)PF03466(LysR_substrate) | 5 | ALA A 142GLY A 145ILE A 269ILE A 109ILE A 94 | NoneNoneIMD A 313 ( 4.1A)NoneNone | 1.01A | 3s53B-3k1nA:undetectable | 3s53B-3k1nA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l49 | ABC SUGAR (RIBOSE)TRANSPORTER,PERIPLASMICSUBSTRATE-BINDINGSUBUNIT (Rhodobactersphaeroides) |
PF13407(Peripla_BP_4) | 5 | LEU A 105ILE A 113GLY A 35ILE A 36ILE A 108 | None | 0.89A | 3s53B-3l49A:undetectable | 3s53B-3l49A:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mt0 | UNCHARACTERIZEDPROTEIN PA1789 (Pseudomonasaeruginosa) |
PF00582(Usp) | 5 | LEU A 89ALA A 24GLY A 29ILE A 4ILE A 7 | NoneNoneNone CL A 290 ( 4.7A)None | 0.83A | 3s53B-3mt0A:undetectable | 3s53B-3mt0A:16.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 9 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.42A | 3s53B-3mwsA:20.0 | 3s53B-3mwsA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3phu | RNA-DIRECTED RNAPOLYMERASE L (Crimean-Congohemorrhagicfeverorthonairovirus) |
PF02338(OTU) | 5 | LEU A 144ALA A 105ILE A 131GLY A 134ILE A 118 | None | 1.18A | 3s53B-3phuA:undetectable | 3s53B-3phuA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3poa | PUTATIVEUNCHARACTERIZEDPROTEIN TB39.8 (Mycobacteriumtuberculosis) |
PF00498(FHA) | 5 | ARG A 16LEU A 10ASP A 83ILE A 85ILE A 92 | None | 1.19A | 3s53B-3poaA:undetectable | 3s53B-3poaA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pse | RNA POLYMERASE (Crimean-Congohemorrhagicfeverorthonairovirus) |
PF02338(OTU) | 5 | LEU A 144ALA A 105ILE A 131GLY A 134ILE A 118 | None | 1.17A | 3s53B-3pseA:undetectable | 3s53B-3pseA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psf | TRANSCRIPTIONELONGATION FACTORSPT6 (Saccharomycescerevisiae) |
PF14635(HHH_7)PF14639(YqgF)PF14641(HTH_44)PF14878(DLD) | 5 | LEU A 799ALA A 767ILE A 750ILE A 803ILE A 802 | None | 1.02A | 3s53B-3psfA:undetectable | 3s53B-3psfA:7.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psi | TRANSCRIPTIONELONGATION FACTORSPT6 (Saccharomycescerevisiae) |
PF14635(HHH_7)PF14639(YqgF)PF14641(HTH_44)PF14878(DLD) | 5 | LEU A 799ALA A 767ILE A 750ILE A 803ILE A 802 | None | 1.08A | 3s53B-3psiA:undetectable | 3s53B-3psiA:6.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pvc | TRNA5-METHYLAMINOMETHYL-2-THIOURIDINEBIOSYNTHESISBIFUNCTIONAL PROTEINMNMC (Yersinia pestis) |
PF01266(DAO)PF05430(Methyltransf_30) | 5 | LEU A 292ALA A 280ILE A 462ILE A 274ILE A 269 | NoneNoneNoneFAD A 690 (-4.8A)None | 1.03A | 3s53B-3pvcA:undetectable | 3s53B-3pvcA:11.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q5i | PROTEIN KINASE (Plasmodiumberghei) |
PF00069(Pkinase)PF13499(EF-hand_7) | 5 | LEU A 152GLY A 177ILE A 178ILE A 170ILE A 207 | None | 1.03A | 3s53B-3q5iA:undetectable | 3s53B-3q5iA:11.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgv | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | LEU A 351ALA A 301ILE A 293ILE A 260ILE A 368 | None | 1.07A | 3s53B-3qgvA:undetectable | 3s53B-3qgvA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqz | PUTATIVEHYDROXYMETHYLGLUTARYL-COA SYNTHASE (Streptococcusmutans) |
PF00195(Chal_sti_synt_N)PF08540(HMG_CoA_synt_C) | 5 | LEU A 342GLY A 144ILE A 145ILE A 350ILE A 44 | None | 1.15A | 3s53B-3sqzA:undetectable | 3s53B-3sqzA:13.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ARG A 8ASP A 25ALA A 28GLY A 49ILE A 50 | SO4 A 101 (-3.8A)017 A 201 (-2.6A)017 A 201 (-3.5A)017 A 201 (-4.0A)017 A 201 (-3.3A) | 0.70A | 3s53B-3t3cA:18.4 | 3s53B-3t3cA:72.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | LEU A 23ASP A 25ALA A 28GLY A 49ILE A 50 | SO4 A 101 (-4.2A)017 A 201 (-2.6A)017 A 201 (-3.5A)017 A 201 (-4.0A)017 A 201 (-3.3A) | 0.45A | 3s53B-3t3cA:18.4 | 3s53B-3t3cA:72.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3t3c | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | LEU A 23ASP A 25ALA A 28GLY A 49PRO A 81 | SO4 A 101 (-4.2A)017 A 201 (-2.6A)017 A 201 (-3.5A)017 A 201 (-4.0A)None | 0.75A | 3s53B-3t3cA:18.4 | 3s53B-3t3cA:72.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 10 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 30ILE A 32GLY A 49ILE A 50PRO A 81ILE A 84 | 017 A 201 ( 4.8A)None017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-4.6A)None017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.52A | 3s53B-3ttpA:19.5 | 3s53B-3ttpA:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u02 | PUTATIVETRANSCRIPTION-ASSOCIATED PROTEIN TFIIS (Pyrococcusfuriosus) |
PF08489(DUF1743) | 5 | ASP A 8GLY A 22ILE A 24ILE A 77ILE A 95 | NoneTPO A 18 ( 3.7A)NoneNoneNone | 1.18A | 3s53B-3u02A:undetectable | 3s53B-3u02A:17.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ARG A 8LEU A 23ASP A 25ALA A 28ASP A 30ILE A 32PRO A 81 | NoneNone017 A 202 ( 2.5A)017 A 201 (-3.4A)017 A 201 ( 4.0A)None017 A 202 (-4.0A) | 0.62A | 3s53B-3u7sA:19.7 | 3s53B-3u7sA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | LEU A 23ASP A 25ALA A 28ILE A 32GLY A 49ILE A 50PRO A 81 | None017 A 202 ( 2.5A)017 A 201 (-3.4A)None017 A 202 (-2.9A)017 A 201 ( 3.5A)017 A 202 (-4.0A) | 0.46A | 3s53B-3u7sA:19.7 | 3s53B-3u7sA:76.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uhl | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | LEU A 23ASP A 25ALA A 28ILE A 32PRO A 81 | None | 0.54A | 3s53B-3uhlA:16.0 | 3s53B-3uhlA:81.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw0 | PECTINESTERASE (Yersiniaenterocolitica) |
PF01095(Pectinesterase) | 5 | LEU A 249ILE A 194ILE A 243ILE A 229ILE A 214 | None | 0.88A | 3s53B-3uw0A:undetectable | 3s53B-3uw0A:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vu1 | PUTATIVEUNCHARACTERIZEDPROTEIN PH0242 (Pyrococcushorikoshii) |
no annotation | 5 | ALA A 620ILE A 639ILE A 605ILE A 624ILE A 622 | None | 0.96A | 3s53B-3vu1A:undetectable | 3s53B-3vu1A:12.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zbq | PHIKZ039 (Pseudomonasvirus phiKZ) |
no annotation | 5 | ALA A 77ILE A 52GLY A 13ILE A 85ILE A 81 | NoneNoneGDP A 999 (-3.6A)NoneNone | 1.09A | 3s53B-3zbqA:undetectable | 3s53B-3zbqA:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bmb | GALECTIN-8 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 5 | LEU A 27ALA A 63ASP A 61ILE A 23ILE A 135 | None | 1.11A | 3s53B-4bmbA:undetectable | 3s53B-4bmbA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c30 | DNA HELICASE II (Deinococcusradiodurans) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | ALA A 180ILE A 125GLY A 130ILE A 135ILE A 144 | None | 0.98A | 3s53B-4c30A:undetectable | 3s53B-4c30A:11.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d28 | CBL-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 24 (Arabidopsisthaliana) |
PF00069(Pkinase) | 5 | ASP A 246ILE A 253GLY A 197ILE A 199ILE A 255 | None | 1.00A | 3s53B-4d28A:undetectable | 3s53B-4d28A:13.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d63 | FIBER KNOB DOMAIN (Turkeysiadenovirus A) |
no annotation | 5 | LEU A 400ILE A 365ILE A 428ILE A 441ILE A 443 | None | 1.06A | 3s53B-4d63A:undetectable | 3s53B-4d63A:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fqz | GALECTIN-8 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 5 | LEU A 27ALA A 63ASP A 61ILE A 23ILE A 135 | None | 1.13A | 3s53B-4fqzA:undetectable | 3s53B-4fqzA:15.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g7a | CARBONATEDEHYDRATASE (Sulfurihydrogenibiumsp. YO3AOP1) |
PF00194(Carb_anhydrase) | 5 | ARG A 219ILE A 98GLY A 122ILE A 32ILE A 34 | None | 1.11A | 3s53B-4g7aA:undetectable | 3s53B-4g7aA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inj | LMO1638 PROTEIN (Listeriamonocytogenes) |
PF02016(Peptidase_S66) | 5 | LEU A 162ALA A 309GLY A 306ILE A 305ILE A 321 | None | 0.88A | 3s53B-4injA:undetectable | 3s53B-4injA:12.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhz | BETA-GLUCURONIDASE (Escherichiacoli) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N) | 5 | LEU A 584ALA A 323ASP A 319ILE A 570ILE A 321 | None | 0.98A | 3s53B-4jhzA:undetectable | 3s53B-4jhzA:9.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jp0 | 43.8 KDAINSECTICIDAL CRYSTALPROTEIN (Bacillusthuringiensis) |
PF05431(Toxin_10) | 5 | LEU A 318ASP A 238ILE A 237GLY A 234ILE A 333 | None | 1.13A | 3s53B-4jp0A:undetectable | 3s53B-4jp0A:13.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpr | THIOREDOXINREDUCTASE 1,CYTOPLASMIC (Rattusnorvegicus) |
no annotation | 5 | LEU E 41ILE E 159ILE E 135ILE E 16ILE E 18 | NoneNoneNoneNoneFAD E 505 (-4.9A) | 0.90A | 3s53B-4kprE:undetectable | 3s53B-4kprE:11.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lsm | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE,CYTOSOLIC (Trypanosomacruzi) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | ALA A 27ILE A 11ILE A 19ILE A 38ILE A 35 | NoneNoneNAD A 401 (-4.0A)NoneNone | 0.90A | 3s53B-4lsmA:undetectable | 3s53B-4lsmA:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nfy | D-3-PHOSPHOGLYCERATEDEHYDROGENASE,PUTATIVE (Entamoebahistolytica) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | ASP A 57ILE A 59ILE A 72ILE A 85ILE A 83 | None | 0.95A | 3s53B-4nfyA:undetectable | 3s53B-4nfyA:17.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25ALA A 28ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | NoneRIT A 500 (-2.4A)RIT A 500 (-3.6A)RIT A 500 (-4.8A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.43A | 3s53B-4njvA:20.5 | 3s53B-4njvA:82.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nky | STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) |
PF00067(p450) | 5 | ILE A 179GLY A 444ILE A 446ILE A 145ILE A 182 | NoneHEM A 600 ( 3.7A)NoneNoneNone | 0.74A | 3s53B-4nkyA:undetectable | 3s53B-4nkyA:13.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4opm | LIPASE (Acinetobacterbaumannii) |
PF12697(Abhydrolase_6) | 5 | LEU A 72ALA A 150GLY A 155ILE A 138ILE A 140 | None | 0.75A | 3s53B-4opmA:undetectable | 3s53B-4opmA:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rml | LATROPHILIN-3 (Mus musculus) |
PF02191(OLF) | 5 | ALA A 334GLY A 386ILE A 387ILE A 353ILE A 343 | None | 0.82A | 3s53B-4rmlA:undetectable | 3s53B-4rmlA:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tnb | G PROTEIN-COUPLEDRECEPTOR KINASE 5 (Homo sapiens) |
PF00069(Pkinase)PF00615(RGS) | 5 | LEU A 45ASP A 52GLY A 63ILE A 62ILE A 49 | None | 0.96A | 3s53B-4tnbA:undetectable | 3s53B-4tnbA:13.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wvw | GALECTIN (Gallus gallus) |
PF00337(Gal-bind_lectin) | 5 | LEU A 26ALA A 62ASP A 60ILE A 22ILE A 134 | None | 1.14A | 3s53B-4wvwA:undetectable | 3s53B-4wvwA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x2r | 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO]IMIDAZOLE-4-CARBOXAMIDE ISOMERASE (Actinomycesurogenitalis) |
PF00977(His_biosynth) | 5 | ARG A 181LEU A 209ALA A 217ILE A 203GLY A 196 | NoneNoneNoneNonePO4 A 301 (-3.6A) | 1.03A | 3s53B-4x2rA:undetectable | 3s53B-4x2rA:18.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xcv | NADP-DEPENDENT2-HYDROXYACIDDEHYDROGENASE (Rhizobium etli) |
PF02826(2-Hacid_dh_C) | 5 | LEU A 66ILE A 90GLY A 72ILE A 11ILE A 69 | None | 1.09A | 3s53B-4xcvA:undetectable | 3s53B-4xcvA:17.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | LEU A 30ASP A 32ALA A 35GLY A 58ILE A 100 | None4B1 A 201 (-2.9A)4B1 A 201 (-3.6A)4B1 A 201 (-3.4A)4B1 A 201 (-4.8A) | 0.33A | 3s53B-4ydfA:13.0 | 3s53B-4ydfA:33.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yo1 | DEGQ (Legionellapneumophila) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | LEU A 331ILE A 294GLY A 243ILE A 322ILE A 320 | None | 0.80A | 3s53B-4yo1A:undetectable | 3s53B-4yo1A:14.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cmn | LATROPHILIN-3 (Homo sapiens) |
PF02191(OLF) | 5 | ALA E 266GLY E 318ILE E 319ILE E 285ILE E 275 | None | 0.74A | 3s53B-5cmnE:undetectable | 3s53B-5cmnE:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ejb | FUSION GLYCOPROTEINF0 (Hendrahenipavirus) |
no annotation | 5 | LEU B 172ALA B 234ILE B 276ILE B 57ILE B 59 | None | 0.82A | 3s53B-5ejbB:undetectable | 3s53B-5ejbB:11.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ftt | ADHESION GPROTEIN-COUPLEDRECEPTOR L3 (Mus musculus) |
PF02140(Gal_Lectin)PF02191(OLF) | 5 | ALA C 334GLY C 386ILE C 387ILE C 353ILE C 343 | None | 0.86A | 3s53B-5fttC:undetectable | 3s53B-5fttC:14.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzg | GALECTIN-8 (Homo sapiens) |
PF00337(Gal-bind_lectin) | 5 | LEU A 27ALA A 63ASP A 61ILE A 23ILE A 135 | None | 1.15A | 3s53B-5gzgA:undetectable | 3s53B-5gzgA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5huq | LACTATE RACEMIZATIONOPERON PROTEIN LARA (Lactobacillusplantarum) |
PF09861(DUF2088) | 5 | ALA A 360ASP A 356ILE A 354GLY A 202ILE A 346 | None | 1.06A | 3s53B-5huqA:undetectable | 3s53B-5huqA:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5it6 | GALECTIN-RELATEDPROTEIN (Gallus gallus) |
PF00337(Gal-bind_lectin) | 5 | ALA A 48ASP A 46ILE A 33ILE A 8ILE A 121 | None | 1.14A | 3s53B-5it6A:undetectable | 3s53B-5it6A:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jcf | MELANOMADIFFERENTIATIONASSOCIATED PROTEIN-5 (Gallus gallus) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 5 | LEU A 708ALA A 725GLY A 695ILE A 777ILE A 761 | None | 1.03A | 3s53B-5jcfA:undetectable | 3s53B-5jcfA:9.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mx0 | FIBROMODULIN (Homo sapiens) |
PF01462(LRRNT)PF13516(LRR_6)PF13855(LRR_8) | 5 | ALA A 359ILE A 376ILE A 330ILE A 325ILE A 355 | None | 1.13A | 3s53B-5mx0A:undetectable | 3s53B-5mx0A:12.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | LEU A 23ASP A 25ALA A 28ASP A 30GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.55A | 3s53B-5t2zA:20.1 | 3s53B-5t2zA:78.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tjf | ALLOPHYCOCYANINALPHA SUBUNIT (Gracilariachilensis) |
PF00502(Phycobilisome) | 5 | ASP A 145ILE A 96GLY A 33ILE A 42ILE A 39 | None | 1.15A | 3s53B-5tjfA:undetectable | 3s53B-5tjfA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wuj | FLAGELLAR M-RINGPROTEINFLAGELLAR MOTORSWITCH PROTEIN FLIG (Helicobacterpylori) |
no annotation | 5 | LEU B 38ALA A 549ASP A 546ILE A 556ILE B 46 | None | 1.19A | 3s53B-5wujB:undetectable | 3s53B-5wujB:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x8g | 2-SUCCINYLBENZOATE--COA LIGASE (Bacillussubtilis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | LEU A 189ALA A 238PRO A 254ILE A 228ILE A 236 | None | 1.05A | 3s53B-5x8gA:undetectable | 3s53B-5x8gA:11.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ysm | CYTOCHROME P450 (Amycolatopsismediterranei) |
no annotation | 5 | ARG A 220ALA A 250ILE A 227ILE A 232ILE A 228 | None | 0.76A | 3s53B-5ysmA:undetectable | 3s53B-5ysmA:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cuq | MACROPHAGE MIGRATIONINHIBITORYFACTOR-LIKE PROTEIN (Entamoebahistolytica) |
no annotation | 5 | LEU A 83ALA A 10GLY A 48ILE A 94ILE A 89 | None | 0.72A | 3s53B-6cuqA:undetectable | 3s53B-6cuqA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | POLYADENYLATIONFACTOR SUBUNIT2,POLYADENYLATIONFACTOR SUBUNIT 2 (Saccharomycescerevisiae) |
no annotation | 5 | ALA D 175ILE D 180ILE D 203ILE D 151ILE D 159 | None | 0.99A | 3s53B-6eojD:undetectable | 3s53B-6eojD:12.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fiv | RETROPEPSIN (Felineimmunodeficiencyvirus) |
PF00077(RVP) | 5 | LEU A 28ASP A 30ALA A 33ILE A 37GLY A 58 | None3TL A 201 (-3.5A)3TL A 201 (-4.0A)3TL A 201 ( 4.8A)3TL A 201 (-3.4A) | 0.39A | 3s53B-6fivA:15.5 | 3s53B-6fivA:29.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | ARG A 8LEU A 23ASP A 25ASP A 30ILE A 82ILE A 84 | NoneNoneNIU A 100 (-2.8A)NoneNIU A 100 (-4.6A)None | 0.84A | 3s53B-6upjA:17.8 | 3s53B-6upjA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | ARG A 8LEU A 23ASP A 25GLY A 49ILE A 84 | NoneNoneNIU A 100 (-2.8A)NIU A 100 ( 3.8A)None | 0.70A | 3s53B-6upjA:17.8 | 3s53B-6upjA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | ARG A 8LEU A 23GLY A 49ILE A 50ILE A 84 | NoneNoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)None | 0.95A | 3s53B-6upjA:17.8 | 3s53B-6upjA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 7 | ASP A 25ALA A 28ASP A 30ILE A 32PRO A 81ILE A 82ILE A 84 | NIU A 100 (-2.8A)NIU A 100 (-3.6A)NoneNoneNoneNIU A 100 (-4.6A)None | 0.70A | 3s53B-6upjA:17.8 | 3s53B-6upjA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ILE A 32GLY A 49PRO A 81ILE A 84 | NIU A 100 (-2.8A)NIU A 100 (-3.6A)NoneNIU A 100 ( 3.8A)NoneNone | 0.69A | 3s53B-6upjA:17.8 | 3s53B-6upjA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | ILE A 32GLY A 49ILE A 50PRO A 81ILE A 84 | NoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)NoneNone | 0.95A | 3s53B-6upjA:17.8 | 3s53B-6upjA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 6 | LEU A 23ASP A 25ASP A 30ILE A 32ILE A 82ILE A 84 | NoneNIU A 100 (-2.8A)NoneNoneNIU A 100 (-4.6A)None | 0.78A | 3s53B-6upjA:17.8 | 3s53B-6upjA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | LEU A 23ASP A 25ILE A 32GLY A 49ILE A 84 | NoneNIU A 100 (-2.8A)NoneNIU A 100 ( 3.8A)None | 0.64A | 3s53B-6upjA:17.8 | 3s53B-6upjA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | LEU A 23ILE A 32GLY A 49ILE A 50ILE A 84 | NoneNoneNIU A 100 ( 3.8A)NIU A 100 (-3.9A)None | 0.91A | 3s53B-6upjA:17.8 | 3s53B-6upjA:52.53 |