SIMILAR PATTERNS OF AMINO ACIDS FOR 3S43_A_478A401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0a PROTEIN (FOLD
BIFUNCTIONAL
PROTEIN)


(Escherichia
coli)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
5 ASP A 229
ILE A 228
VAL A 263
GLY A   8
ILE A 155
None
0.92A 3s43A-1b0aA:
undetectable
3s43A-1b0aA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqy PLASMINOGEN
ACTIVATOR


(Trimeresurus
stejnegeri)
PF00089
(Trypsin)
5 ALA A 183
ILE A 138
VAL A 213
GLY A 216
ILE A 160
None
None
None
0GJ  A   1 (-3.5A)
None
0.99A 3s43A-1bqyA:
undetectable
3s43A-1bqyA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddz CARBONIC ANHYDRASE

(Porphyridium
purpureum)
PF00484
(Pro_CA)
5 ILE A 413
GLY A 402
ILE A 401
ILE A 114
ILE A 414
None
0.91A 3s43A-1ddzA:
undetectable
3s43A-1ddzA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drk D-RIBOSE-BINDING
PROTEIN


(Escherichia
coli)
PF13407
(Peripla_BP_4)
5 ALA A  78
ILE A  63
VAL A  71
GLY A  95
ILE A  86
None
1.00A 3s43A-1drkA:
undetectable
3s43A-1drkA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN


(Escherichia
coli)
PF12804
(NTP_transf_3)
5 ALA A  42
VAL A  11
GLY A   9
ILE A   7
ILE A 105
None
0.93A 3s43A-1fr9A:
undetectable
3s43A-1fr9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC


(Thermotoga
maritima)
PF03775
(MinC_C)
5 ALA A 134
ILE A 148
VAL A 160
ILE A 108
ILE A 132
None
0.95A 3s43A-1hf2A:
undetectable
3s43A-1hf2A:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  25
ALA A  28
ASP A  30
ILE A  50
ILE A  84
A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 ( 4.9A)
A79  A 800 (-3.8A)
A79  A 800 (-3.6A)
0.67A 3s43A-1hvcA:
14.1
3s43A-1hvcA:
44.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  25
ALA A  28
GLY A  49
ILE A  50
ILE A  84
A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.8A)
A79  A 800 (-3.6A)
0.36A 3s43A-1hvcA:
14.1
3s43A-1hvcA:
44.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  25
ALA A  28
GLY A  49
ILE A  50
ILE A  84
A79  A 800 (-2.8A)
A79  A 800 (-3.2A)
A79  A 800 (-3.4A)
A79  A 800 ( 4.0A)
A79  A 800 (-3.8A)
0.42A 3s43A-1hvcA:
14.1
3s43A-1hvcA:
44.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini)
PF02274
(Amidinotransf)
5 ASP A  69
ILE A  70
GLY A  18
ILE A  17
ILE A 362
None
0.91A 3s43A-1lxyA:
undetectable
3s43A-1lxyA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op2 VENOM SERINE
PROTEINASE


(Deinagkistrodon
acutus)
PF00089
(Trypsin)
5 ALA A 183
ILE A 138
VAL A 213
GLY A 216
ILE A 160
None
0.98A 3s43A-1op2A:
undetectable
3s43A-1op2A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvv RIBOFLAVIN SYNTHASE

(Bacillus
subtilis)
no annotation 5 ALA A  34
ILE A  15
VAL A  43
ILE A 112
ILE A  76
None
0.89A 3s43A-1rvvA:
undetectable
3s43A-1rvvA:
26.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
5 ASP A  25
ALA A  28
ASP A  30
ILE A  82
ILE A  84
None
0.55A 3s43A-1sivA:
18.4
3s43A-1sivA:
53.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
6 ASP A  25
ALA A  28
ILE A  32
GLY A  48
ILE A  82
ILE A  84
None
0.91A 3s43A-1sivA:
18.4
3s43A-1sivA:
53.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
8 ASP A  25
ALA A  28
ILE A  32
VAL A  47
GLY A  49
ILE A  50
ILE A  82
ILE A  84
None
0.37A 3s43A-1sivA:
18.4
3s43A-1sivA:
53.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdt TETRAHYDRODIPICOLINA
TE-N-SUCCINYLTRANSFE
RASE


(Mycobacterium
bovis)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2)
5 ALA A 150
ILE A 178
VAL A 190
GLY A 163
ILE A 152
None
0.95A 3s43A-1tdtA:
undetectable
3s43A-1tdtA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to6 GLYCERATE KINASE

(Neisseria
meningitidis)
PF02595
(Gly_kinase)
5 ILE A 315
GLY A 363
ILE A  31
ILE A   5
ILE A 283
None
0.99A 3s43A-1to6A:
undetectable
3s43A-1to6A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE


(Bacillus sp.
JAMB-602)
PF00150
(Cellulase)
5 ALA A 175
ILE A 190
VAL A 209
ILE A 153
ILE A 155
None
0.95A 3s43A-1wkyA:
undetectable
3s43A-1wkyA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT


(Chlamydia
trachomatis)
PF00268
(Ribonuc_red_sm)
5 ASP A 236
ILE A 238
GLY A 194
ILE A 195
ILE A 303
None
1.00A 3s43A-2aniA:
undetectable
3s43A-2aniA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ani RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA SUBUNIT


(Chlamydia
trachomatis)
PF00268
(Ribonuc_red_sm)
5 ILE A 238
GLY A 194
ILE A 195
ILE A 257
ILE A 303
None
0.93A 3s43A-2aniA:
undetectable
3s43A-2aniA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0r POSSIBLE ADENYL
CYCLASE-ASSOCIATED
PROTEIN


(Cryptosporidium
parvum)
PF08603
(CAP_C)
5 ILE A  94
VAL A  87
ILE A 103
ILE A 115
ILE A 113
None
0.74A 3s43A-2b0rA:
undetectable
3s43A-2b0rA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bty ACETYLGLUTAMATE
KINASE


(Thermotoga
maritima)
PF00696
(AA_kinase)
5 ILE A 165
GLY A 169
ILE A 170
ILE A 152
ILE A 120
None
0.99A 3s43A-2btyA:
undetectable
3s43A-2btyA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2y METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE-METHEN
YLTETRAHYDROFOLATE
CYCLOHYDROLASE


(Mycobacterium
tuberculosis)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
5 ASP A 230
ILE A 229
VAL A 262
GLY A   8
ILE A 154
None
0.87A 3s43A-2c2yA:
undetectable
3s43A-2c2yA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE


(Pyrococcus
horikoshii)
PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB)
5 ALA A 113
ASP A 104
GLY A  85
ILE A  95
ILE A 112
None
BT5  A1301 (-3.3A)
None
None
None
0.97A 3s43A-2djzA:
undetectable
3s43A-2djzA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE


(Enterovirus C)
PF00548
(Peptidase_C3)
PF00680
(RdRP_1)
5 ILE 1  49
VAL 1  16
ILE 1  36
ILE 1  56
ILE 1  47
None
1.00A 3s43A-2ijd1:
2.4
3s43A-2ijd1:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jrz HISTONE DEMETHYLASE
JARID1C


(Homo sapiens)
PF01388
(ARID)
5 ASP A  61
ILE A  58
GLY A  80
ILE A  79
ILE A  48
None
0.98A 3s43A-2jrzA:
undetectable
3s43A-2jrzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY


(Streptococcus
pneumoniae)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ALA A 178
ASP A 179
VAL A 147
ILE A 152
ILE A  86
None
BGC  A 458 (-2.4A)
None
None
None
0.99A 3s43A-2pokA:
undetectable
3s43A-2pokA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq1 MOLYBDENUM COFACTOR
BIOSYNTHESIS MOG


(Aquifex
aeolicus)
PF00994
(MoCF_biosynth)
5 ALA A   6
ILE A  38
GLY A   9
ILE A  72
ILE A 164
None
0.71A 3s43A-2qq1A:
undetectable
3s43A-2qq1A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvo UNCHARACTERIZED
PROTEIN AF_1382


(Archaeoglobus
fulgidus)
no annotation 5 ILE A  71
GLY A  77
ILE A  80
ILE A  17
ILE A  51
None
0.97A 3s43A-2qvoA:
undetectable
3s43A-2qvoA:
25.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 ASP A  25
ALA A  28
ASP A  30
ILE A  32
VAL A  47
ILE A  84
AB1  A 501 (-2.4A)
AB1  A 501 (-3.5A)
AB1  A 501 (-3.8A)
AB1  A 501 (-4.5A)
AB1  A 501 ( 4.9A)
AB1  A 501 ( 4.2A)
0.60A 3s43A-2rkfA:
20.8
3s43A-2rkfA:
83.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
7 ASP A  25
ALA A  28
ILE A  32
VAL A  47
GLY A  49
ILE A  50
ILE A  84
AB1  A 501 (-2.4A)
AB1  A 501 (-3.5A)
AB1  A 501 (-4.5A)
AB1  A 501 ( 4.9A)
AB1  A 501 (-3.5A)
AB1  A 501 (-3.8A)
AB1  A 501 ( 4.2A)
0.55A 3s43A-2rkfA:
20.8
3s43A-2rkfA:
83.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd3 ATP
PHOSPHORIBOSYLTRANSF
ERASE


(Methanothermobacter
thermautotrophicus)
PF01634
(HisG)
PF08029
(HisG_C)
5 ALA A 114
ASP A 134
ILE A 133
ILE A 156
ILE A 110
None
IMD  A1288 (-3.8A)
None
None
None
0.97A 3s43A-2vd3A:
undetectable
3s43A-2vd3A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqe JUMONJI/ARID
DOMAIN-CONTAINING
PROTEIN 1D


(Homo sapiens)
PF01388
(ARID)
5 ASP A 131
ILE A 128
GLY A 150
ILE A 149
ILE A 118
None
0.98A 3s43A-2yqeA:
undetectable
3s43A-2yqeA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR


(Thermococcus
kodakarensis)
PF00082
(Peptidase_S8)
5 ALA A 211
GLY A 217
ILE A 218
ILE A 256
ILE A 204
None
None
CA  A1004 (-4.8A)
None
None
0.95A 3s43A-2z2zA:
undetectable
3s43A-2z2zA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C


(Saccharomyces
cerevisiae)
PF00400
(WD40)
5 ALA A 134
ILE A 139
ILE A 162
ILE A 110
ILE A 118
None
0.99A 3s43A-3acpA:
undetectable
3s43A-3acpA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1c FLAVIN-CONTAINING
PUTATIVE
MONOOXYGENASE


(Staphylococcus
aureus)
PF13738
(Pyr_redox_3)
5 ALA A   7
ILE A 113
VAL A 136
GLY A  10
ILE A 122
None
None
None
FAD  A 500 (-3.3A)
None
0.99A 3s43A-3d1cA:
undetectable
3s43A-3d1cA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eg4 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E


(Brucella suis)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2)
5 ALA A 157
ILE A 185
VAL A 197
GLY A 170
ILE A 159
None
0.98A 3s43A-3eg4A:
undetectable
3s43A-3eg4A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)


(Sulfolobus
solfataricus)
PF07992
(Pyr_redox_2)
5 ALA A 114
ASP A  17
GLY A  13
ILE A  44
ILE A  19
None
0.90A 3s43A-3f8rA:
undetectable
3s43A-3f8rA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l07 BIFUNCTIONAL PROTEIN
FOLD


(Francisella
tularensis)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
5 ASP A 228
ILE A 227
VAL A 261
GLY A   6
ILE A 154
None
0.82A 3s43A-3l07A:
undetectable
3s43A-3l07A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrv PRE-MRNA-SPLICING
FACTOR 19


(Saccharomyces
cerevisiae)
no annotation 5 ALA A 488
ASP A 478
GLY A 485
ILE A 447
ILE A 436
None
0.96A 3s43A-3lrvA:
undetectable
3s43A-3lrvA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT


(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF04053
(Coatomer_WDAD)
5 VAL A  58
GLY A  18
ILE A  19
ILE A  39
ILE A  70
None
0.84A 3s43A-3mkqA:
undetectable
3s43A-3mkqA:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp7 PREPROTEIN
TRANSLOCASE SUBUNIT
SECY


(Pyrococcus
furiosus)
PF00344
(SecY)
PF10559
(Plug_translocon)
5 ILE A 290
VAL A  65
GLY A 435
ILE A 436
ILE A 289
None
0.93A 3s43A-3mp7A:
undetectable
3s43A-3mp7A:
12.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 ASP A  25
ALA A  28
ASP A  30
GLY A  49
ILE A  50
ILE A  84
None
0.46A 3s43A-3mwsA:
20.1
3s43A-3mwsA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956


(Vibrio
parahaemolyticus)
no annotation 5 ALA A 366
GLY A 472
ILE A 413
ILE A 464
ILE A 299
None
0.89A 3s43A-3nlcA:
undetectable
3s43A-3nlcA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus)
PF00117
(GATase)
PF06418
(CTP_synth_N)
6 ILE A 296
VAL A 532
GLY A 527
ILE A 524
ILE A 312
ILE A 316
None
1.48A 3s43A-3nvaA:
undetectable
3s43A-3nvaA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0k ALDO/KETO REDUCTASE

(Brucella
abortus)
PF00248
(Aldo_ket_red)
5 ALA A 202
ILE A  33
GLY A 156
ILE A 247
ILE A 245
None
0.95A 3s43A-3o0kA:
undetectable
3s43A-3o0kA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1h PERIPLASMIC PROTEIN
TORT


(Vibrio
parahaemolyticus)
PF00532
(Peripla_BP_1)
6 ALA B 165
ASP B 196
ILE B 194
GLY B 225
ILE B 192
ILE B 164
None
1.44A 3s43A-3o1hB:
undetectable
3s43A-3o1hB:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE


(Gloydius
saxatilis)
PF00089
(Trypsin)
5 ALA A 181
ILE A 135
VAL A 209
GLY A 212
ILE A 157
None
0.95A 3s43A-3s69A:
undetectable
3s43A-3s69A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9b VIPERA RUSSELLI
PROTEINASE RVV-V
GAMMA


(Daboia
siamensis)
PF00089
(Trypsin)
5 ALA A 183
ILE A 138
VAL A 213
GLY A 216
ILE A 160
None
0.93A 3s43A-3s9bA:
undetectable
3s43A-3s9bA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sti PROTEASE DEGQ

(Escherichia
coli)
PF13365
(Trypsin_2)
5 ALA A  25
VAL A 144
GLY A 189
ILE A 129
ILE A 127
None
0.87A 3s43A-3stiA:
undetectable
3s43A-3stiA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E


(Burkholderia
pseudomallei)
PF00132
(Hexapep)
PF14602
(Hexapep_2)
PF14805
(THDPS_N_2)
5 ALA A 189
ILE A 217
VAL A 229
GLY A 202
ILE A 191
None
0.90A 3s43A-3tk8A:
undetectable
3s43A-3tk8A:
16.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
8 ASP A  25
ALA A  28
ASP A  30
ILE A  32
VAL A  47
GLY A  49
ILE A  50
ILE A  84
017  A 201 (-2.6A)
017  A 201 (-3.4A)
017  A 201 (-4.6A)
None
017  A 201 ( 4.9A)
017  A 201 (-3.0A)
017  A 201 (-3.3A)
017  A 201 (-4.7A)
0.65A 3s43A-3ttpA:
19.7
3s43A-3ttpA:
77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  25
ALA A  28
ILE A  32
GLY A  48
ILE A  84
017  A 201 (-2.6A)
017  A 201 (-3.4A)
None
None
017  A 201 (-4.7A)
0.84A 3s43A-3ttpA:
19.7
3s43A-3ttpA:
77.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  25
ALA A  28
ILE A  32
GLY A  49
ILE A  50
017  A 202 ( 2.5A)
017  A 201 (-3.4A)
None
017  A 202 (-2.9A)
017  A 201 ( 3.5A)
0.57A 3s43A-3u7sA:
19.9
3s43A-3u7sA:
75.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uiz CHIMERA PROTEIN OF
SEFD AND SEFA


(Salmonella
enterica)
PF05775
(AfaD)
5 ASP A 106
ILE A 138
ILE A  95
ILE A  18
ILE A 103
None
0.92A 3s43A-3uizA:
undetectable
3s43A-3uizA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu1 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0242


(Pyrococcus
horikoshii)
no annotation 5 ALA A 620
ILE A 639
ILE A 605
ILE A 624
ILE A 622
None
0.97A 3s43A-3vu1A:
undetectable
3s43A-3vu1A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6o ALPHA-N-ACETYLGLUCOS
AMINIDASE FAMILY
PROTEIN


(Clostridium
perfringens)
PF00754
(F5_F8_type_C)
5 ALA A1318
ILE A1231
VAL A1217
GLY A1219
ILE A1336
None
0.88A 3s43A-4a6oA:
undetectable
3s43A-4a6oA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
5 ALA A 180
ILE A 125
GLY A 130
ILE A 135
ILE A 144
None
0.98A 3s43A-4c30A:
undetectable
3s43A-4c30A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2


(Homo sapiens)
PF02854
(MIF4G)
5 ILE A 344
GLY A 276
ILE A 277
ILE A 287
ILE A 319
None
0.99A 3s43A-4cemA:
undetectable
3s43A-4cemA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6u ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Acinetobacter
baumannii)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
6 ALA A  17
ILE A  37
VAL A  49
ILE A  12
ILE A   7
ILE A  19
None
1.16A 3s43A-4e6uA:
undetectable
3s43A-4e6uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE


(Thermothelomyces
thermophila)
no annotation 5 ALA A 113
ILE A 128
VAL A 185
ILE A 202
ILE A 144
None
0.98A 3s43A-4g4iA:
undetectable
3s43A-4g4iA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1


(Bothrops
jararacussu)
PF00089
(Trypsin)
5 ALA A 164
ILE A 119
VAL A 192
GLY A 195
ILE A 141
None
0.78A 3s43A-4gsoA:
undetectable
3s43A-4gsoA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE


(Pseudomonas
savastanoi)
PF01593
(Amino_oxidase)
5 ALA A  42
ILE A 303
VAL A 327
GLY A  45
ILE A 312
None
None
None
FAD  A 601 (-3.1A)
None
1.00A 3s43A-4iv9A:
undetectable
3s43A-4iv9A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j73 COATOMER SUBUNIT
BETA'


(Saccharomyces
cerevisiae)
PF00400
(WD40)
5 VAL A  58
GLY A  18
ILE A  19
ILE A  39
ILE A  70
None
0.80A 3s43A-4j73A:
undetectable
3s43A-4j73A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC


(Trypanosoma
cruzi)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 ALA A  27
ILE A  11
ILE A  19
ILE A  38
ILE A  35
None
None
NAD  A 401 (-4.0A)
None
None
0.95A 3s43A-4lsmA:
undetectable
3s43A-4lsmA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN


(Bordetella
pertussis)
PF13458
(Peripla_BP_6)
5 ILE A  45
GLY A   7
ILE A  76
ILE A 315
ILE A   4
None
0.96A 3s43A-4mptA:
undetectable
3s43A-4mptA:
17.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 ASP A  25
ALA A  28
ASP A  30
GLY A  49
ILE A  50
ILE A  84
RIT  A 500 (-2.4A)
RIT  A 500 (-3.6A)
RIT  A 500 (-4.8A)
RIT  A 500 (-3.4A)
RIT  A 500 (-4.3A)
RIT  A 500 (-4.3A)
0.41A 3s43A-4njvA:
21.0
3s43A-4njvA:
81.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE


(Homo sapiens)
PF00067
(p450)
5 ILE A 179
GLY A 444
ILE A 446
ILE A 145
ILE A 182
None
HEM  A 600 ( 3.7A)
None
None
None
0.92A 3s43A-4nkyA:
undetectable
3s43A-4nkyA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ose PUTATIVE HYDROLASE

(Rickettsia
typhi)
PF00561
(Abhydrolase_1)
5 ALA A 122
ILE A 234
GLY A 115
ILE A 116
ILE A 230
None
0.91A 3s43A-4oseA:
undetectable
3s43A-4oseA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phb UNCHARACTERIZED
PROTEIN


(Ruminiclostridium
thermocellum)
PF14262
(Cthe_2159)
5 ASP A 215
ILE A 217
GLY A 174
ILE A 149
ILE A 208
GD  A 402 (-2.4A)
None
None
None
None
0.96A 3s43A-4phbA:
undetectable
3s43A-4phbA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r37 PUTATIVE
ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Bacteroides
fragilis)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ALA A 144
ILE A 122
GLY A 129
ILE A 138
ILE A 140
None
0.82A 3s43A-4r37A:
undetectable
3s43A-4r37A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rml LATROPHILIN-3

(Mus musculus)
PF02191
(OLF)
5 ALA A 334
GLY A 386
ILE A 387
ILE A 353
ILE A 343
None
0.79A 3s43A-4rmlA:
undetectable
3s43A-4rmlA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzl RESTRICTION
ENDONUCLEASE LPNPI


(Legionella
pneumophila)
no annotation 6 ILE A 190
VAL A 185
GLY A 143
ILE A 126
ILE A  40
ILE A  37
None
1.44A 3s43A-4rzlA:
undetectable
3s43A-4rzlA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ydf HTLV-1 PROTEASE

(Primate
T-lymphotropic
virus 1)
PF00077
(RVP)
5 ASP A  32
ALA A  35
VAL A  56
GLY A  58
ILE A 100
4B1  A 201 (-2.9A)
4B1  A 201 (-3.6A)
None
4B1  A 201 (-3.4A)
4B1  A 201 (-4.8A)
0.56A 3s43A-4ydfA:
13.0
3s43A-4ydfA:
33.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE


(Vesicular
stomatitis
virus)
PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap)
5 ILE A 351
GLY A 271
ILE A 274
ILE A 292
ILE A 339
None
1.00A 3s43A-5a22A:
undetectable
3s43A-5a22A:
4.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cej 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE


(Yersinia pestis)
PF13561
(adh_short_C2)
6 ALA A 154
VAL A 140
GLY A 137
ILE A 136
ILE A  89
ILE A 106
None
1.08A 3s43A-5cejA:
undetectable
3s43A-5cejA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmn LATROPHILIN-3

(Homo sapiens)
PF02191
(OLF)
5 ALA E 266
GLY E 318
ILE E 319
ILE E 285
ILE E 275
None
0.69A 3s43A-5cmnE:
undetectable
3s43A-5cmnE:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f42 ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Francisella
tularensis)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
5 ALA A  60
ILE A  93
ILE A  86
ILE A  50
ILE A  62
None
0.86A 3s43A-5f42A:
undetectable
3s43A-5f42A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE


(Listeria
monocytogenes)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
5 ILE A 863
VAL A 838
GLY A 840
ILE A 847
ILE A 765
None
0.95A 3s43A-5fbuA:
undetectable
3s43A-5fbuA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3


(Mus musculus)
PF02140
(Gal_Lectin)
PF02191
(OLF)
5 ALA C 334
GLY C 386
ILE C 387
ILE C 353
ILE C 343
None
0.85A 3s43A-5fttC:
undetectable
3s43A-5fttC:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g47 SFTSV GC

(SFTS
phlebovirus)
PF07245
(Phlebovirus_G2)
5 ALA A 815
ILE A 807
VAL A 712
GLY A 681
ILE A 824
None
0.94A 3s43A-5g47A:
undetectable
3s43A-5g47A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1


(Homo sapiens)
PF08423
(Rad51)
PF14520
(HHH_5)
5 ALA A 224
GLY A 288
ILE A 291
ILE A 122
ILE A 265
None
0.88A 3s43A-5h1cA:
undetectable
3s43A-5h1cA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5in2 EXTRACELLULAR
SUPEROXIDE DISMUTASE
[CU-ZN]


(Onchocerca
volvulus)
PF00080
(Sod_Cu)
5 ALA A  95
VAL A  14
GLY A  16
ILE A  17
ILE A  87
None
0.75A 3s43A-5in2A:
undetectable
3s43A-5in2A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1


(Saccharomyces
cerevisiae)
PF04950
(RIBIOP_C)
PF08142
(AARP2CN)
5 ILE A 557
VAL A 259
GLY A 257
ILE A 285
ILE A 306
None
0.92A 3s43A-5iw7A:
undetectable
3s43A-5iw7A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6c PUTATIVE REDUCTASE

(Clostridioides
difficile)
PF00881
(Nitroreductase)
5 ALA A  37
ILE A  33
ILE A  52
ILE A 152
ILE A 105
None
0.95A 3s43A-5j6cA:
undetectable
3s43A-5j6cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6c PUTATIVE REDUCTASE

(Clostridioides
difficile)
PF00881
(Nitroreductase)
5 ALA A  81
ILE A 119
ILE A  61
ILE A 136
ILE A 151
None
FMN  A 201 (-4.8A)
None
None
None
0.96A 3s43A-5j6cA:
undetectable
3s43A-5j6cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npy FLAGELLAR BASAL BODY
PROTEIN


(Helicobacter
pylori)
no annotation 5 VAL A 144
GLY A 146
ILE A 147
ILE A 152
ILE A 179
None
0.98A 3s43A-5npyA:
undetectable
3s43A-5npyA:
9.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  25
ALA A  28
GLY A  49
ILE A  50
ILE A  84
None
0.44A 3s43A-5t2zA:
20.0
3s43A-5t2zA:
77.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL


(Homo sapiens)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
5 ASP A 273
ILE A 272
VAL A 312
GLY A  42
ILE A 189
None
None
NAD  A 401 ( 4.3A)
None
None
0.93A 3s43A-5tc4A:
undetectable
3s43A-5tc4A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ts5 AMINE OXIDASE

(Bothrops atrox)
PF01593
(Amino_oxidase)
5 ILE A 369
GLY A 390
ILE A 392
ILE A 400
ILE A 355
None
0.97A 3s43A-5ts5A:
undetectable
3s43A-5ts5A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE


(Cryptococcus
neoformans)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
5 ILE A 271
VAL A 161
ILE A 169
ILE A 351
ILE A 262
None
1.00A 3s43A-5v4lA:
undetectable
3s43A-5v4lA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D)
PF00680
(RdRP_1)
5 ILE A 301
VAL A 326
GLY A 323
ILE A 299
ILE A 300
None
0.97A 3s43A-5xe0A:
undetectable
3s43A-5xe0A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9p -

(-)
no annotation 5 ASP A 170
ILE A 169
ILE A 151
ILE A 157
ILE A  77
None
0.95A 3s43A-5y9pA:
undetectable
3s43A-5y9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12


(Homo sapiens)
no annotation 5 ALA A 993
ASP A 995
GLY A 923
ILE A 925
ILE A 989
None
0.93A 3s43A-6b3eA:
undetectable
3s43A-6b3eA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ekv TOXIN COMPLEX
COMPONENT ORF-X2


(Clostridium
botulinum)
no annotation 5 ALA A 675
ILE A 524
GLY A 668
ILE A 690
ILE A 701
None
0.90A 3s43A-6ekvA:
undetectable
3s43A-6ekvA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elu VSG PROTEIN
SERUM RESISTANCE
ASSOCIATED


(Trypanosoma
brucei)
no annotation 5 ALA A 120
ILE A 130
GLY A  52
ILE A  53
ILE A 115
None
1.00A 3s43A-6eluA:
undetectable
3s43A-6eluA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2


(Saccharomyces
cerevisiae)
no annotation 5 ALA D 175
ILE D 180
ILE D 203
ILE D 151
ILE D 159
None
0.88A 3s43A-6eojD:
undetectable
3s43A-6eojD:
12.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2)
PF00077
(RVP)
7 ASP A  25
ALA A  28
ASP A  30
ILE A  32
VAL A  47
ILE A  82
ILE A  84
NIU  A 100 (-2.8A)
NIU  A 100 (-3.6A)
None
None
None
NIU  A 100 (-4.6A)
None
0.69A 3s43A-6upjA:
17.8
3s43A-6upjA:
52.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2)
PF00077
(RVP)
5 ASP A  25
ALA A  28
GLY A  48
ILE A  82
ILE A  84
NIU  A 100 (-2.8A)
NIU  A 100 (-3.6A)
None
NIU  A 100 (-4.6A)
None
0.81A 3s43A-6upjA:
17.8
3s43A-6upjA:
52.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2)
PF00077
(RVP)
5 ASP A  25
ALA A  28
VAL A  47
GLY A  49
ILE A  84
NIU  A 100 (-2.8A)
NIU  A 100 (-3.6A)
None
NIU  A 100 ( 3.8A)
None
0.73A 3s43A-6upjA:
17.8
3s43A-6upjA:
52.53