SIMILAR PATTERNS OF AMINO ACIDS FOR 3S43_A_478A401_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b0a | PROTEIN (FOLDBIFUNCTIONALPROTEIN) (Escherichiacoli) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | ASP A 229ILE A 228VAL A 263GLY A 8ILE A 155 | None | 0.92A | 3s43A-1b0aA:undetectable | 3s43A-1b0aA:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqy | PLASMINOGENACTIVATOR (Trimeresurusstejnegeri) |
PF00089(Trypsin) | 5 | ALA A 183ILE A 138VAL A 213GLY A 216ILE A 160 | NoneNoneNone0GJ A 1 (-3.5A)None | 0.99A | 3s43A-1bqyA:undetectable | 3s43A-1bqyA:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ddz | CARBONIC ANHYDRASE (Porphyridiumpurpureum) |
PF00484(Pro_CA) | 5 | ILE A 413GLY A 402ILE A 401ILE A 114ILE A 414 | None | 0.91A | 3s43A-1ddzA:undetectable | 3s43A-1ddzA:11.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1drk | D-RIBOSE-BINDINGPROTEIN (Escherichiacoli) |
PF13407(Peripla_BP_4) | 5 | ALA A 78ILE A 63VAL A 71GLY A 95ILE A 86 | None | 1.00A | 3s43A-1drkA:undetectable | 3s43A-1drkA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fr9 | MOLYBDOPTERIN-GUANINE DINUCLEOTIDEBIOSYNTHESIS PROTEIN (Escherichiacoli) |
PF12804(NTP_transf_3) | 5 | ALA A 42VAL A 11GLY A 9ILE A 7ILE A 105 | None | 0.93A | 3s43A-1fr9A:undetectable | 3s43A-1fr9A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hf2 | SEPTUMSITE-DETERMININGPROTEIN MINC (Thermotogamaritima) |
PF03775(MinC_C) | 5 | ALA A 134ILE A 148VAL A 160ILE A 108ILE A 132 | None | 0.95A | 3s43A-1hf2A:undetectable | 3s43A-1hf2A:21.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 30ILE A 50ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 ( 4.9A)A79 A 800 (-3.8A)A79 A 800 (-3.6A) | 0.67A | 3s43A-1hvcA:14.1 | 3s43A-1hvcA:44.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28GLY A 49ILE A 50ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.1A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 (-3.6A) | 0.36A | 3s43A-1hvcA:14.1 | 3s43A-1hvcA:44.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28GLY A 49ILE A 50ILE A 84 | A79 A 800 (-2.8A)A79 A 800 (-3.2A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 (-3.8A) | 0.42A | 3s43A-1hvcA:14.1 | 3s43A-1hvcA:44.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lxy | ARGININE DEIMINASE (Mycoplasmaarginini) |
PF02274(Amidinotransf) | 5 | ASP A 69ILE A 70GLY A 18ILE A 17ILE A 362 | None | 0.91A | 3s43A-1lxyA:undetectable | 3s43A-1lxyA:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1op2 | VENOM SERINEPROTEINASE (Deinagkistrodonacutus) |
PF00089(Trypsin) | 5 | ALA A 183ILE A 138VAL A 213GLY A 216ILE A 160 | None | 0.98A | 3s43A-1op2A:undetectable | 3s43A-1op2A:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rvv | RIBOFLAVIN SYNTHASE (Bacillussubtilis) |
no annotation | 5 | ALA A 34ILE A 15VAL A 43ILE A 112ILE A 76 | None | 0.89A | 3s43A-1rvvA:undetectable | 3s43A-1rvvA:26.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ASP A 30ILE A 82ILE A 84 | None | 0.55A | 3s43A-1sivA:18.4 | 3s43A-1sivA:53.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ILE A 32GLY A 48ILE A 82ILE A 84 | None | 0.91A | 3s43A-1sivA:18.4 | 3s43A-1sivA:53.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ILE A 32VAL A 47GLY A 49ILE A 50ILE A 82ILE A 84 | None | 0.37A | 3s43A-1sivA:18.4 | 3s43A-1sivA:53.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdt | TETRAHYDRODIPICOLINATE-N-SUCCINYLTRANSFERASE (Mycobacteriumbovis) |
PF00132(Hexapep)PF14602(Hexapep_2)PF14805(THDPS_N_2) | 5 | ALA A 150ILE A 178VAL A 190GLY A 163ILE A 152 | None | 0.95A | 3s43A-1tdtA:undetectable | 3s43A-1tdtA:16.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to6 | GLYCERATE KINASE (Neisseriameningitidis) |
PF02595(Gly_kinase) | 5 | ILE A 315GLY A 363ILE A 31ILE A 5ILE A 283 | None | 0.99A | 3s43A-1to6A:undetectable | 3s43A-1to6A:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wky | ENDO-BETA-1,4-MANNANASE (Bacillus sp.JAMB-602) |
PF00150(Cellulase) | 5 | ALA A 175ILE A 190VAL A 209ILE A 153ILE A 155 | None | 0.95A | 3s43A-1wkyA:undetectable | 3s43A-1wkyA:12.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ani | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASEBETA SUBUNIT (Chlamydiatrachomatis) |
PF00268(Ribonuc_red_sm) | 5 | ASP A 236ILE A 238GLY A 194ILE A 195ILE A 303 | None | 1.00A | 3s43A-2aniA:undetectable | 3s43A-2aniA:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ani | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASEBETA SUBUNIT (Chlamydiatrachomatis) |
PF00268(Ribonuc_red_sm) | 5 | ILE A 238GLY A 194ILE A 195ILE A 257ILE A 303 | None | 0.93A | 3s43A-2aniA:undetectable | 3s43A-2aniA:14.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b0r | POSSIBLE ADENYLCYCLASE-ASSOCIATEDPROTEIN (Cryptosporidiumparvum) |
PF08603(CAP_C) | 5 | ILE A 94VAL A 87ILE A 103ILE A 115ILE A 113 | None | 0.74A | 3s43A-2b0rA:undetectable | 3s43A-2b0rA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bty | ACETYLGLUTAMATEKINASE (Thermotogamaritima) |
PF00696(AA_kinase) | 5 | ILE A 165GLY A 169ILE A 170ILE A 152ILE A 120 | None | 0.99A | 3s43A-2btyA:undetectable | 3s43A-2btyA:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c2y | METHYLENETETRAHYDROFOLATEDEHYDROGENASE-METHENYLTETRAHYDROFOLATECYCLOHYDROLASE (Mycobacteriumtuberculosis) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | ASP A 230ILE A 229VAL A 262GLY A 8ILE A 154 | None | 0.87A | 3s43A-2c2yA:undetectable | 3s43A-2c2yA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2djz | 235AA LONGHYPOTHETICALBIOTIN-[ACETYL-COA-CARBOXYLASE] LIGASE (Pyrococcushorikoshii) |
PF02237(BPL_C)PF03099(BPL_LplA_LipB) | 5 | ALA A 113ASP A 104GLY A 85ILE A 95ILE A 112 | NoneBT5 A1301 (-3.3A)NoneNoneNone | 0.97A | 3s43A-2djzA:undetectable | 3s43A-2djzA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijd | PICORNAIN 3C,RNA-DIRECTED RNAPOLYMERASE (Enterovirus C) |
PF00548(Peptidase_C3)PF00680(RdRP_1) | 5 | ILE 1 49VAL 1 16ILE 1 36ILE 1 56ILE 1 47 | None | 1.00A | 3s43A-2ijd1:2.4 | 3s43A-2ijd1:10.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jrz | HISTONE DEMETHYLASEJARID1C (Homo sapiens) |
PF01388(ARID) | 5 | ASP A 61ILE A 58GLY A 80ILE A 79ILE A 48 | None | 0.98A | 3s43A-2jrzA:undetectable | 3s43A-2jrzA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pok | PEPTIDASE,M20/M25/M40 FAMILY (Streptococcuspneumoniae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ALA A 178ASP A 179VAL A 147ILE A 152ILE A 86 | NoneBGC A 458 (-2.4A)NoneNoneNone | 0.99A | 3s43A-2pokA:undetectable | 3s43A-2pokA:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qq1 | MOLYBDENUM COFACTORBIOSYNTHESIS MOG (Aquifexaeolicus) |
PF00994(MoCF_biosynth) | 5 | ALA A 6ILE A 38GLY A 9ILE A 72ILE A 164 | None | 0.71A | 3s43A-2qq1A:undetectable | 3s43A-2qq1A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qvo | UNCHARACTERIZEDPROTEIN AF_1382 (Archaeoglobusfulgidus) |
no annotation | 5 | ILE A 71GLY A 77ILE A 80ILE A 17ILE A 51 | None | 0.97A | 3s43A-2qvoA:undetectable | 3s43A-2qvoA:25.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 30ILE A 32VAL A 47ILE A 84 | AB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 (-4.5A)AB1 A 501 ( 4.9A)AB1 A 501 ( 4.2A) | 0.60A | 3s43A-2rkfA:20.8 | 3s43A-2rkfA:83.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 7 | ASP A 25ALA A 28ILE A 32VAL A 47GLY A 49ILE A 50ILE A 84 | AB1 A 501 (-2.4A)AB1 A 501 (-3.5A)AB1 A 501 (-4.5A)AB1 A 501 ( 4.9A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 ( 4.2A) | 0.55A | 3s43A-2rkfA:20.8 | 3s43A-2rkfA:83.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vd3 | ATPPHOSPHORIBOSYLTRANSFERASE (Methanothermobacterthermautotrophicus) |
PF01634(HisG)PF08029(HisG_C) | 5 | ALA A 114ASP A 134ILE A 133ILE A 156ILE A 110 | NoneIMD A1288 (-3.8A)NoneNoneNone | 0.97A | 3s43A-2vd3A:undetectable | 3s43A-2vd3A:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yqe | JUMONJI/ARIDDOMAIN-CONTAININGPROTEIN 1D (Homo sapiens) |
PF01388(ARID) | 5 | ASP A 131ILE A 128GLY A 150ILE A 149ILE A 118 | None | 0.98A | 3s43A-2yqeA:undetectable | 3s43A-2yqeA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2z | TK-SUBTILISINPRECURSOR (Thermococcuskodakarensis) |
PF00082(Peptidase_S8) | 5 | ALA A 211GLY A 217ILE A 218ILE A 256ILE A 204 | NoneNone CA A1004 (-4.8A)NoneNone | 0.95A | 3s43A-2z2zA:undetectable | 3s43A-2z2zA:12.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3acp | WD REPEAT-CONTAININGPROTEIN YGL004C (Saccharomycescerevisiae) |
PF00400(WD40) | 5 | ALA A 134ILE A 139ILE A 162ILE A 110ILE A 118 | None | 0.99A | 3s43A-3acpA:undetectable | 3s43A-3acpA:13.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1c | FLAVIN-CONTAININGPUTATIVEMONOOXYGENASE (Staphylococcusaureus) |
PF13738(Pyr_redox_3) | 5 | ALA A 7ILE A 113VAL A 136GLY A 10ILE A 122 | NoneNoneNoneFAD A 500 (-3.3A)None | 0.99A | 3s43A-3d1cA:undetectable | 3s43A-3d1cA:14.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eg4 | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-SUCCINYLTRANSFERASE (Brucella suis) |
PF00132(Hexapep)PF14602(Hexapep_2)PF14805(THDPS_N_2) | 5 | ALA A 157ILE A 185VAL A 197GLY A 170ILE A 159 | None | 0.98A | 3s43A-3eg4A:undetectable | 3s43A-3eg4A:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f8r | THIOREDOXINREDUCTASE (TRXB-3) (Sulfolobussolfataricus) |
PF07992(Pyr_redox_2) | 5 | ALA A 114ASP A 17GLY A 13ILE A 44ILE A 19 | None | 0.90A | 3s43A-3f8rA:undetectable | 3s43A-3f8rA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l07 | BIFUNCTIONAL PROTEINFOLD (Francisellatularensis) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | ASP A 228ILE A 227VAL A 261GLY A 6ILE A 154 | None | 0.82A | 3s43A-3l07A:undetectable | 3s43A-3l07A:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lrv | PRE-MRNA-SPLICINGFACTOR 19 (Saccharomycescerevisiae) |
no annotation | 5 | ALA A 488ASP A 478GLY A 485ILE A 447ILE A 436 | None | 0.96A | 3s43A-3lrvA:undetectable | 3s43A-3lrvA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mkq | COATOMERBETA'-SUBUNIT (Saccharomycescerevisiae) |
PF00400(WD40)PF04053(Coatomer_WDAD) | 5 | VAL A 58GLY A 18ILE A 19ILE A 39ILE A 70 | None | 0.84A | 3s43A-3mkqA:undetectable | 3s43A-3mkqA:9.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mp7 | PREPROTEINTRANSLOCASE SUBUNITSECY (Pyrococcusfuriosus) |
PF00344(SecY)PF10559(Plug_translocon) | 5 | ILE A 290VAL A 65GLY A 435ILE A 436ILE A 289 | None | 0.93A | 3s43A-3mp7A:undetectable | 3s43A-3mp7A:12.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 30GLY A 49ILE A 50ILE A 84 | None | 0.46A | 3s43A-3mwsA:20.1 | 3s43A-3mwsA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nlc | UNCHARACTERIZEDPROTEIN VP0956 (Vibrioparahaemolyticus) |
no annotation | 5 | ALA A 366GLY A 472ILE A 413ILE A 464ILE A 299 | None | 0.89A | 3s43A-3nlcA:undetectable | 3s43A-3nlcA:11.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nva | CTP SYNTHASE (Sulfolobussolfataricus) |
PF00117(GATase)PF06418(CTP_synth_N) | 6 | ILE A 296VAL A 532GLY A 527ILE A 524ILE A 312ILE A 316 | None | 1.48A | 3s43A-3nvaA:undetectable | 3s43A-3nvaA:11.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0k | ALDO/KETO REDUCTASE (Brucellaabortus) |
PF00248(Aldo_ket_red) | 5 | ALA A 202ILE A 33GLY A 156ILE A 247ILE A 245 | None | 0.95A | 3s43A-3o0kA:undetectable | 3s43A-3o0kA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o1h | PERIPLASMIC PROTEINTORT (Vibrioparahaemolyticus) |
PF00532(Peripla_BP_1) | 6 | ALA B 165ASP B 196ILE B 194GLY B 225ILE B 192ILE B 164 | None | 1.44A | 3s43A-3o1hB:undetectable | 3s43A-3o1hB:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s69 | THROMBIN-LIKE ENZYMEDEFIBRASE (Gloydiussaxatilis) |
PF00089(Trypsin) | 5 | ALA A 181ILE A 135VAL A 209GLY A 212ILE A 157 | None | 0.95A | 3s43A-3s69A:undetectable | 3s43A-3s69A:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s9b | VIPERA RUSSELLIPROTEINASE RVV-VGAMMA (Daboiasiamensis) |
PF00089(Trypsin) | 5 | ALA A 183ILE A 138VAL A 213GLY A 216ILE A 160 | None | 0.93A | 3s43A-3s9bA:undetectable | 3s43A-3s9bA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sti | PROTEASE DEGQ (Escherichiacoli) |
PF13365(Trypsin_2) | 5 | ALA A 25VAL A 144GLY A 189ILE A 129ILE A 127 | None | 0.87A | 3s43A-3stiA:undetectable | 3s43A-3stiA:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tk8 | 2,3,4,5-TETRAHYDROPYRIDINE-2,6-DICARBOXYLATEN-SUCCINYLTRANSFERASE (Burkholderiapseudomallei) |
PF00132(Hexapep)PF14602(Hexapep_2)PF14805(THDPS_N_2) | 5 | ALA A 189ILE A 217VAL A 229GLY A 202ILE A 191 | None | 0.90A | 3s43A-3tk8A:undetectable | 3s43A-3tk8A:16.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 8 | ASP A 25ALA A 28ASP A 30ILE A 32VAL A 47GLY A 49ILE A 50ILE A 84 | 017 A 201 (-2.6A)017 A 201 (-3.4A)017 A 201 (-4.6A)None017 A 201 ( 4.9A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.7A) | 0.65A | 3s43A-3ttpA:19.7 | 3s43A-3ttpA:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ILE A 32GLY A 48ILE A 84 | 017 A 201 (-2.6A)017 A 201 (-3.4A)NoneNone017 A 201 (-4.7A) | 0.84A | 3s43A-3ttpA:19.7 | 3s43A-3ttpA:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u7s | POL POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28ILE A 32GLY A 49ILE A 50 | 017 A 202 ( 2.5A)017 A 201 (-3.4A)None017 A 202 (-2.9A)017 A 201 ( 3.5A) | 0.57A | 3s43A-3u7sA:19.9 | 3s43A-3u7sA:75.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uiz | CHIMERA PROTEIN OFSEFD AND SEFA (Salmonellaenterica) |
PF05775(AfaD) | 5 | ASP A 106ILE A 138ILE A 95ILE A 18ILE A 103 | None | 0.92A | 3s43A-3uizA:undetectable | 3s43A-3uizA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vu1 | PUTATIVEUNCHARACTERIZEDPROTEIN PH0242 (Pyrococcushorikoshii) |
no annotation | 5 | ALA A 620ILE A 639ILE A 605ILE A 624ILE A 622 | None | 0.97A | 3s43A-3vu1A:undetectable | 3s43A-3vu1A:12.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a6o | ALPHA-N-ACETYLGLUCOSAMINIDASE FAMILYPROTEIN (Clostridiumperfringens) |
PF00754(F5_F8_type_C) | 5 | ALA A1318ILE A1231VAL A1217GLY A1219ILE A1336 | None | 0.88A | 3s43A-4a6oA:undetectable | 3s43A-4a6oA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c30 | DNA HELICASE II (Deinococcusradiodurans) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | ALA A 180ILE A 125GLY A 130ILE A 135ILE A 144 | None | 0.98A | 3s43A-4c30A:undetectable | 3s43A-4c30A:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cem | REGULATOR OFNONSENSE TRANSCRIPTS2 (Homo sapiens) |
PF02854(MIF4G) | 5 | ILE A 344GLY A 276ILE A 277ILE A 287ILE A 319 | None | 0.99A | 3s43A-4cemA:undetectable | 3s43A-4cemA:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e6u | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Acinetobacterbaumannii) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 6 | ALA A 17ILE A 37VAL A 49ILE A 12ILE A 7ILE A 19 | None | 1.16A | 3s43A-4e6uA:undetectable | 3s43A-4e6uA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g4i | 4-O-METHYL-GLUCURONOYL METHYLESTERASE (Thermothelomycesthermophila) |
no annotation | 5 | ALA A 113ILE A 128VAL A 185ILE A 202ILE A 144 | None | 0.98A | 3s43A-4g4iA:undetectable | 3s43A-4g4iA:12.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gso | THROMBIN-LIKE ENZYMEBJUSSUSP-1 (Bothropsjararacussu) |
PF00089(Trypsin) | 5 | ALA A 164ILE A 119VAL A 192GLY A 195ILE A 141 | None | 0.78A | 3s43A-4gsoA:undetectable | 3s43A-4gsoA:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iv9 | TRYPTOPHAN2-MONOOXYGENASE (Pseudomonassavastanoi) |
PF01593(Amino_oxidase) | 5 | ALA A 42ILE A 303VAL A 327GLY A 45ILE A 312 | NoneNoneNoneFAD A 601 (-3.1A)None | 1.00A | 3s43A-4iv9A:undetectable | 3s43A-4iv9A:10.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j73 | COATOMER SUBUNITBETA' (Saccharomycescerevisiae) |
PF00400(WD40) | 5 | VAL A 58GLY A 18ILE A 19ILE A 39ILE A 70 | None | 0.80A | 3s43A-4j73A:undetectable | 3s43A-4j73A:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lsm | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE,CYTOSOLIC (Trypanosomacruzi) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | ALA A 27ILE A 11ILE A 19ILE A 38ILE A 35 | NoneNoneNAD A 401 (-4.0A)NoneNone | 0.95A | 3s43A-4lsmA:undetectable | 3s43A-4lsmA:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mpt | PUTATIVELEU/ILE/VAL-BINDINGPROTEIN (Bordetellapertussis) |
PF13458(Peripla_BP_6) | 5 | ILE A 45GLY A 7ILE A 76ILE A 315ILE A 4 | None | 0.96A | 3s43A-4mptA:undetectable | 3s43A-4mptA:17.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 6 | ASP A 25ALA A 28ASP A 30GLY A 49ILE A 50ILE A 84 | RIT A 500 (-2.4A)RIT A 500 (-3.6A)RIT A 500 (-4.8A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-4.3A) | 0.41A | 3s43A-4njvA:21.0 | 3s43A-4njvA:81.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nky | STEROID17-ALPHA-HYDROXYLASE/17,20 LYASE (Homo sapiens) |
PF00067(p450) | 5 | ILE A 179GLY A 444ILE A 446ILE A 145ILE A 182 | NoneHEM A 600 ( 3.7A)NoneNoneNone | 0.92A | 3s43A-4nkyA:undetectable | 3s43A-4nkyA:12.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ose | PUTATIVE HYDROLASE (Rickettsiatyphi) |
PF00561(Abhydrolase_1) | 5 | ALA A 122ILE A 234GLY A 115ILE A 116ILE A 230 | None | 0.91A | 3s43A-4oseA:undetectable | 3s43A-4oseA:17.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4phb | UNCHARACTERIZEDPROTEIN (Ruminiclostridiumthermocellum) |
PF14262(Cthe_2159) | 5 | ASP A 215ILE A 217GLY A 174ILE A 149ILE A 208 | GD A 402 (-2.4A)NoneNoneNoneNone | 0.96A | 3s43A-4phbA:undetectable | 3s43A-4phbA:14.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r37 | PUTATIVEACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Bacteroidesfragilis) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ALA A 144ILE A 122GLY A 129ILE A 138ILE A 140 | None | 0.82A | 3s43A-4r37A:undetectable | 3s43A-4r37A:23.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rml | LATROPHILIN-3 (Mus musculus) |
PF02191(OLF) | 5 | ALA A 334GLY A 386ILE A 387ILE A 353ILE A 343 | None | 0.79A | 3s43A-4rmlA:undetectable | 3s43A-4rmlA:15.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rzl | RESTRICTIONENDONUCLEASE LPNPI (Legionellapneumophila) |
no annotation | 6 | ILE A 190VAL A 185GLY A 143ILE A 126ILE A 40ILE A 37 | None | 1.44A | 3s43A-4rzlA:undetectable | 3s43A-4rzlA:19.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ydf | HTLV-1 PROTEASE (PrimateT-lymphotropicvirus 1) |
PF00077(RVP) | 5 | ASP A 32ALA A 35VAL A 56GLY A 58ILE A 100 | 4B1 A 201 (-2.9A)4B1 A 201 (-3.6A)None4B1 A 201 (-3.4A)4B1 A 201 (-4.8A) | 0.56A | 3s43A-4ydfA:13.0 | 3s43A-4ydfA:33.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a22 | VESICULAR STOMATITISVIRUS L POLYMERASE (Vesicularstomatitisvirus) |
PF00946(Mononeg_RNA_pol)PF14314(Methyltrans_Mon)PF14318(Mononeg_mRNAcap) | 5 | ILE A 351GLY A 271ILE A 274ILE A 292ILE A 339 | None | 1.00A | 3s43A-5a22A:undetectable | 3s43A-5a22A:4.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cej | 3-OXOACYL-[ACYL-CARRIER PROTEIN]REDUCTASE (Yersinia pestis) |
PF13561(adh_short_C2) | 6 | ALA A 154VAL A 140GLY A 137ILE A 136ILE A 89ILE A 106 | None | 1.08A | 3s43A-5cejA:undetectable | 3s43A-5cejA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cmn | LATROPHILIN-3 (Homo sapiens) |
PF02191(OLF) | 5 | ALA E 266GLY E 318ILE E 319ILE E 285ILE E 275 | None | 0.69A | 3s43A-5cmnE:undetectable | 3s43A-5cmnE:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f42 | ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINEO-ACYLTRANSFERASE (Francisellatularensis) |
PF00132(Hexapep)PF13720(Acetyltransf_11) | 5 | ALA A 60ILE A 93ILE A 86ILE A 50ILE A 62 | None | 0.86A | 3s43A-5f42A:undetectable | 3s43A-5f42A:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fbu | PHOSPHOENOLPYRUVATESYNTHASE (Listeriamonocytogenes) |
PF00391(PEP-utilizers)PF01326(PPDK_N) | 5 | ILE A 863VAL A 838GLY A 840ILE A 847ILE A 765 | None | 0.95A | 3s43A-5fbuA:undetectable | 3s43A-5fbuA:7.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ftt | ADHESION GPROTEIN-COUPLEDRECEPTOR L3 (Mus musculus) |
PF02140(Gal_Lectin)PF02191(OLF) | 5 | ALA C 334GLY C 386ILE C 387ILE C 353ILE C 343 | None | 0.85A | 3s43A-5fttC:undetectable | 3s43A-5fttC:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g47 | SFTSV GC (SFTSphlebovirus) |
PF07245(Phlebovirus_G2) | 5 | ALA A 815ILE A 807VAL A 712GLY A 681ILE A 824 | None | 0.94A | 3s43A-5g47A:undetectable | 3s43A-5g47A:12.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h1c | DNA REPAIR PROTEINRAD51 HOMOLOG 1 (Homo sapiens) |
PF08423(Rad51)PF14520(HHH_5) | 5 | ALA A 224GLY A 288ILE A 291ILE A 122ILE A 265 | None | 0.88A | 3s43A-5h1cA:undetectable | 3s43A-5h1cA:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5in2 | EXTRACELLULARSUPEROXIDE DISMUTASE[CU-ZN] (Onchocercavolvulus) |
PF00080(Sod_Cu) | 5 | ALA A 95VAL A 14GLY A 16ILE A 17ILE A 87 | None | 0.75A | 3s43A-5in2A:undetectable | 3s43A-5in2A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iw7 | RIBOSOME BIOGENESISPROTEINTSR1,RIBOSOMEBIOGENESIS PROTEINTSR1 (Saccharomycescerevisiae) |
PF04950(RIBIOP_C)PF08142(AARP2CN) | 5 | ILE A 557VAL A 259GLY A 257ILE A 285ILE A 306 | None | 0.92A | 3s43A-5iw7A:undetectable | 3s43A-5iw7A:10.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6c | PUTATIVE REDUCTASE (Clostridioidesdifficile) |
PF00881(Nitroreductase) | 5 | ALA A 37ILE A 33ILE A 52ILE A 152ILE A 105 | None | 0.95A | 3s43A-5j6cA:undetectable | 3s43A-5j6cA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6c | PUTATIVE REDUCTASE (Clostridioidesdifficile) |
PF00881(Nitroreductase) | 5 | ALA A 81ILE A 119ILE A 61ILE A 136ILE A 151 | NoneFMN A 201 (-4.8A)NoneNoneNone | 0.96A | 3s43A-5j6cA:undetectable | 3s43A-5j6cA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5npy | FLAGELLAR BASAL BODYPROTEIN (Helicobacterpylori) |
no annotation | 5 | VAL A 144GLY A 146ILE A 147ILE A 152ILE A 179 | None | 0.98A | 3s43A-5npyA:undetectable | 3s43A-5npyA:9.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 25ALA A 28GLY A 49ILE A 50ILE A 84 | None | 0.44A | 3s43A-5t2zA:20.0 | 3s43A-5t2zA:77.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tc4 | BIFUNCTIONALMETHYLENETETRAHYDROFOLATEDEHYDROGENASE/CYCLOHYDROLASE,MITOCHONDRIAL (Homo sapiens) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | ASP A 273ILE A 272VAL A 312GLY A 42ILE A 189 | NoneNoneNAD A 401 ( 4.3A)NoneNone | 0.93A | 3s43A-5tc4A:undetectable | 3s43A-5tc4A:12.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ts5 | AMINE OXIDASE (Bothrops atrox) |
PF01593(Amino_oxidase) | 5 | ILE A 369GLY A 390ILE A 392ILE A 400ILE A 355 | None | 0.97A | 3s43A-5ts5A:undetectable | 3s43A-5ts5A:11.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v4l | ADENYLOSUCCINATELYASE (Cryptococcusneoformans) |
PF00206(Lyase_1)PF10397(ADSL_C) | 5 | ILE A 271VAL A 161ILE A 169ILE A 351ILE A 262 | None | 1.00A | 3s43A-5v4lA:undetectable | 3s43A-5v4lA:11.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xe0 | GENOME POLYPROTEIN (Enterovirus D) |
PF00680(RdRP_1) | 5 | ILE A 301VAL A 326GLY A 323ILE A 299ILE A 300 | None | 0.97A | 3s43A-5xe0A:undetectable | 3s43A-5xe0A:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y9p | - (-) |
no annotation | 5 | ASP A 170ILE A 169ILE A 151ILE A 157ILE A 77 | None | 0.95A | 3s43A-5y9pA:undetectable | 3s43A-5y9pA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b3e | CYCLIN-DEPENDENTKINASE 12 (Homo sapiens) |
no annotation | 5 | ALA A 993ASP A 995GLY A 923ILE A 925ILE A 989 | None | 0.93A | 3s43A-6b3eA:undetectable | 3s43A-6b3eA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ekv | TOXIN COMPLEXCOMPONENT ORF-X2 (Clostridiumbotulinum) |
no annotation | 5 | ALA A 675ILE A 524GLY A 668ILE A 690ILE A 701 | None | 0.90A | 3s43A-6ekvA:undetectable | 3s43A-6ekvA:9.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6elu | VSG PROTEINSERUM RESISTANCEASSOCIATED (Trypanosomabrucei) |
no annotation | 5 | ALA A 120ILE A 130GLY A 52ILE A 53ILE A 115 | None | 1.00A | 3s43A-6eluA:undetectable | 3s43A-6eluA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | POLYADENYLATIONFACTOR SUBUNIT2,POLYADENYLATIONFACTOR SUBUNIT 2 (Saccharomycescerevisiae) |
no annotation | 5 | ALA D 175ILE D 180ILE D 203ILE D 151ILE D 159 | None | 0.88A | 3s43A-6eojD:undetectable | 3s43A-6eojD:12.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 7 | ASP A 25ALA A 28ASP A 30ILE A 32VAL A 47ILE A 82ILE A 84 | NIU A 100 (-2.8A)NIU A 100 (-3.6A)NoneNoneNoneNIU A 100 (-4.6A)None | 0.69A | 3s43A-6upjA:17.8 | 3s43A-6upjA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | ASP A 25ALA A 28GLY A 48ILE A 82ILE A 84 | NIU A 100 (-2.8A)NIU A 100 (-3.6A)NoneNIU A 100 (-4.6A)None | 0.81A | 3s43A-6upjA:17.8 | 3s43A-6upjA:52.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 5 | ASP A 25ALA A 28VAL A 47GLY A 49ILE A 84 | NIU A 100 (-2.8A)NIU A 100 (-3.6A)NoneNIU A 100 ( 3.8A)None | 0.73A | 3s43A-6upjA:17.8 | 3s43A-6upjA:52.53 |