SIMILAR PATTERNS OF AMINO ACIDS FOR 3S3V_A_TOPA193

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a25 PROTEIN KINASE C
(BETA)

(Rattus
norvegicus) 		PF00168
(C2) 		4 ASP A 187
LEU A 191
ILE A 215
PRO A 194
 CA  A 290 (-2.2A)
None
None
None
 1.23A 3s3vA-1a25A:
undetectable		 3s3vA-1a25A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdb CIS-BIPHENYL-2,3-DIH
YDRODIOL-2,3-DEHYDRO
GENASE

(Pseudomonas sp.) 		PF00106
(adh_short) 		4 LEU A 130
ILE A  84
PRO A  85
PHE A 139
 None
 1.17A 3s3vA-1bdbA:
0.6		 3s3vA-1bdbA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2i PROTEIN (RESTRICTION
ENDONUCLEASE BGLII)

(Bacillus
subtilis) 		PF09195
(Endonuc-BglII) 		4 LEU A  91
ILE A  72
PRO A  73
PHE A  76
 None
 1.16A 3s3vA-1d2iA:
0.0		 3s3vA-1d2iA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		4 ASP A 139
LEU A 399
ILE A 402
PRO A 137
 None
 1.16A 3s3vA-1f26A:
undetectable		 3s3vA-1f26A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1glv GLUTATHIONE SYNTHASE

(Escherichia
coli) 		PF02951
(GSH-S_N)
PF02955
(GSH-S_ATP) 		4 ASP A 273
LEU A 272
PRO A 287
PHE A 269
 None
 1.21A 3s3vA-1glvA:
0.0		 3s3vA-1glvA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ASP A1536
LEU A1539
ILE A1574
PHE A1573
 None
 1.20A 3s3vA-1larA:
0.0		 3s3vA-1larA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lf9 GLUCOAMYLASE

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00723
(Glyco_hydro_15)
PF09137
(Glucodextran_N) 		4 ASP A 396
LEU A 395
ILE A 402
PRO A 401
 None
 0.99A 3s3vA-1lf9A:
undetectable		 3s3vA-1lf9A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkt TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09008
(Head_binding) 		4 LEU A  79
ILE A  16
PRO A  15
PHE A  17
 None
 1.14A 3s3vA-1lktA:
undetectable		 3s3vA-1lktA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mp1 SER/ARG-RELATED
NUCLEAR MATRIX
PROTEIN

(Homo sapiens) 		PF01480
(PWI) 		4 LEU A  45
ILE A 119
PRO A 120
PHE A 123
 None
 1.14A 3s3vA-1mp1A:
undetectable		 3s3vA-1mp1A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj1 PROLINE-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 ASP A 222
LEU A 202
ILE A 431
PHE A 433
 None
 1.23A 3s3vA-1nj1A:
0.0		 3s3vA-1nj1A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		4 LEU A 627
ILE A 606
PRO A 601
PHE A 609
 None
 1.15A 3s3vA-1p15A:
undetectable		 3s3vA-1p15A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		4 LEU A 298
ILE A 190
PRO A 189
PHE A 242
 None
 1.16A 3s3vA-1pweA:
2.6		 3s3vA-1pweA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3f TRNA PSEUDOURIDINE
SYNTHASE B

(Escherichia
coli) 		PF01509
(TruB_N)
PF09157
(TruB-C_2)
PF16198
(TruB_C_2) 		4 ASP A 238
LEU A 237
ILE A 231
PRO A 232
 None
 1.19A 3s3vA-1r3fA:
undetectable		 3s3vA-1r3fA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 ASP A 312
ILE A 175
PRO A 176
PHE A 177
 TYM  A 501 (-3.2A)
TYM  A 501 ( 4.5A)
TYM  A 501 (-4.4A)
None
 1.24A 3s3vA-1r6uA:
undetectable		 3s3vA-1r6uA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rg6 SECOND SPLICE
VARIANT P63

(Homo sapiens) 		PF07647
(SAM_2) 		4 ASP A  24
LEU A  23
ILE A  50
PHE A  54
 None
 1.16A 3s3vA-1rg6A:
undetectable		 3s3vA-1rg6A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdh NEI ENDONUCLEASE
VIII-LIKE 1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		4 LEU A 166
ILE A 161
PRO A 160
PHE A 191
 None
 1.12A 3s3vA-1tdhA:
undetectable		 3s3vA-1tdhA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 314
LEU A 313
ILE A 278
PRO A 275
 None
 1.20A 3s3vA-1u0uA:
undetectable		 3s3vA-1u0uA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A1039
ILE A1018
PRO A1013
PHE A1021
 None
 1.24A 3s3vA-1yguA:
undetectable		 3s3vA-1yguA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1e STILBENE SYNTHASE

(Arachis
hypogaea) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 311
LEU A 310
ILE A 275
PRO A 272
 None
 1.06A 3s3vA-1z1eA:
undetectable		 3s3vA-1z1eA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3v SITE-SPECIFIC
RECOMBINASE INTI4

(Vibrio cholerae) 		PF00589
(Phage_integrase)
PF13495
(Phage_int_SAM_4) 		4 LEU A  75
ILE A  34
PRO A  42
PHE A   5
 None
 1.21A 3s3vA-2a3vA:
undetectable		 3s3vA-2a3vA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boy 3-CHLOROCATECHOL
1,2-DIOXYGENASE

(Rhodococcus
opacus) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 ASP A 233
LEU A 232
ILE A 104
PHE A 105
 None
 1.21A 3s3vA-2boyA:
undetectable		 3s3vA-2boyA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 ASP A 356
LEU A 357
ILE A 350
PHE A 349
 None
 1.16A 3s3vA-2cg9A:
undetectable		 3s3vA-2cg9A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 327
LEU A 326
ILE A 288
PRO A 285
 None
None
None
COA  A 500 ( 4.5A)
 1.09A 3s3vA-2d52A:
undetectable		 3s3vA-2d52A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		4 ASP A  70
LEU A 174
ILE A  74
PHE A  43
 None
 1.24A 3s3vA-2d5rA:
undetectable		 3s3vA-2d5rA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 ASP A 163
LEU A 160
ILE A 126
PHE A 122
 None
None
None
NAP  A 799 ( 4.7A)
 0.97A 3s3vA-2dpgA:
1.8		 3s3vA-2dpgA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASP A 111
LEU A 108
ILE A 437
PHE A 435
 None
 1.22A 3s3vA-2fjaA:
undetectable		 3s3vA-2fjaA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 ASP A 122
LEU A 119
ILE A 103
PHE A 102
 None
 1.21A 3s3vA-2genA:
undetectable		 3s3vA-2genA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj2 WSV230

(White spot
syndrome virus) 		PF09625
(VP9) 		4 ASP A   9
LEU A  47
ILE A  73
PRO A  75
 CD  A 201 (-2.0A)
None
None
None
 1.15A 3s3vA-2gj2A:
undetectable		 3s3vA-2gj2A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 LEU A 812
ILE A 791
PRO A 786
PHE A 794
 None
 1.23A 3s3vA-2i1yA:
undetectable		 3s3vA-2i1yA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kfs CONSERVED
HYPOTHETICAL
REGULATORY PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 ASP A  21
ILE A  66
PRO A  67
PHE A  70
 None
 1.09A 3s3vA-2kfsA:
undetectable		 3s3vA-2kfsA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhf UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF00027
(cNMP_binding) 		4 ASP A  76
LEU A  78
ILE A  73
PHE A  49
 None
 1.08A 3s3vA-2mhfA:
undetectable		 3s3vA-2mhfA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 329
LEU A 328
ILE A 293
PRO A 290
 None
 0.95A 3s3vA-2p0uA:
undetectable		 3s3vA-2p0uA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE

(Agrobacterium
fabrum) 		PF03562
(MltA)
PF06725
(3D) 		4 ASP A 221
LEU A 220
ILE A 215
PRO A 214
 None
 1.04A 3s3vA-2pnwA:
undetectable		 3s3vA-2pnwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		4 ASP A 272
LEU A  19
ILE A 277
PHE A 366
 None
 1.24A 3s3vA-2qr6A:
undetectable		 3s3vA-2qr6A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtv SMALL COPII COAT
GTPASE SAR1

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 ASP B  73
LEU B  74
ILE B  94
PHE B  96
 MG  B 210 ( 4.2A)
None
None
None
 1.15A 3s3vA-2qtvB:
undetectable		 3s3vA-2qtvB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vnl BIFUNCTIONAL TAIL
PROTEIN, PIIGCN4

(Saccharomyces
cerevisiae;
Salmonella
virus P22) 		PF09008
(Head_binding) 		4 LEU A  79
ILE A  16
PRO A  15
PHE A  17
 None
 1.17A 3s3vA-2vnlA:
undetectable		 3s3vA-2vnlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus) 		no annotation 4 ASP A  92
LEU A  93
ILE A  89
PHE A 115
 None
 1.17A 3s3vA-2wteA:
1.3		 3s3vA-2wteA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA
PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 ASP A1040
LEU B 679
ILE A 959
PHE A 973
 None
 1.14A 3s3vA-2y3aA:
undetectable		 3s3vA-2y3aA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y93 CIS-2,3-DIHYDROBIPHE
NYL-2,3-DIOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF00106
(adh_short) 		4 LEU A 130
ILE A  84
PRO A  85
PHE A 139
 None
 1.21A 3s3vA-2y93A:
1.3		 3s3vA-2y93A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 309
ILE A  28
PRO A  29
PHE A  30
 None
 0.95A 3s3vA-2yzmA:
1.8		 3s3vA-2yzmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		4 LEU A 162
ILE A 268
PRO A  75
PHE A 266
 None
 1.14A 3s3vA-3a4tA:
2.2		 3s3vA-3a4tA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 304
LEU A 303
ILE A 268
PRO A 265
 None
 1.10A 3s3vA-3a5rA:
undetectable		 3s3vA-3a5rA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1

(Symbiobacterium
toebii) 		PF00551
(Formyl_trans_N) 		4 ASP A  20
LEU A  19
ILE A 182
PRO A 179
 None
 1.21A 3s3vA-3aufA:
undetectable		 3s3vA-3aufA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 321
LEU A 320
ILE A 285
PRO A 282
 None
 1.20A 3s3vA-3awkA:
undetectable		 3s3vA-3awkA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cjx PROTEIN OF UNKNOWN
FUNCTION WITH A
CUPIN-LIKE FOLD

(Cupriavidus
pinatubonensis) 		no annotation 4 ASP A 146
ILE A  35
PRO A  37
PHE A  36
 None
 0.98A 3s3vA-3cjxA:
undetectable		 3s3vA-3cjxA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		4 LEU A  46
ILE A 112
PRO A 113
PHE A 116
 RJ6  A 609 (-3.8A)
RJ6  A 609 (-4.8A)
None
None
 0.56A 3s3vA-3dg8A:
22.8		 3s3vA-3dg8A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A 199
LEU A 200
ILE A 261
PHE A 260
 None
 1.15A 3s3vA-3g2fA:
undetectable		 3s3vA-3g2fA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 ASP A 315
LEU A 316
ILE A 345
PHE A 233
 None
 1.07A 3s3vA-3i1iA:
undetectable		 3s3vA-3i1iA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcc T-CELL SURFACE
GLYCOPROTEIN CD4

(Homo sapiens) 		PF00047
(ig)
PF05790
(C2-set) 		4 ASP D  80
ILE D  76
PRO D 121
PHE D  98
 None
 1.17A 3s3vA-3jccD:
undetectable		 3s3vA-3jccD:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k11 PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		4 ASP A 300
ILE A 228
PRO A 229
PHE A 225
 None
 1.24A 3s3vA-3k11A:
undetectable		 3s3vA-3k11A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Pectobacterium
atrosepticum) 		PF00155
(Aminotran_1_2) 		4 ASP A 219
LEU A 248
ILE A 125
PHE A 148
 PLP  A 500 (-2.7A)
None
None
None
 1.02A 3s3vA-3ly1A:
undetectable		 3s3vA-3ly1A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg6 PROTEASOME COMPONENT
PRE3

(Saccharomyces
cerevisiae) 		no annotation 4 ASP N  32
LEU N  34
ILE N 173
PHE N 187
 None
 1.20A 3s3vA-3mg6N:
undetectable		 3s3vA-3mg6N:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohg UNCHARACTERIZED
PROTEIN FROM DUF2233
FAMILY

(Bacteroides
ovatus) 		PF09992
(NAGPA) 		4 ASP A 132
LEU A 269
PRO A  92
PHE A  90
 None
 1.23A 3s3vA-3ohgA:
undetectable		 3s3vA-3ohgA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Francisella
tularensis) 		PF00793
(DAHP_synth_1) 		4 ASP A 137
ILE A  68
PRO A  71
PHE A 112
 None
 1.22A 3s3vA-3tqkA:
undetectable		 3s3vA-3tqkA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 ASP A 898
LEU A 897
ILE A 862
PRO A 859
 None
 1.08A 3s3vA-3tsyA:
undetectable		 3s3vA-3tsyA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 LEU A  46
ILE A 112
PRO A 113
PHE A 116
 NDP  A 610 (-4.4A)
1CY  A 609 (-4.4A)
None
None
 0.67A 3s3vA-3um6A:
22.5		 3s3vA-3um6A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uy4 PANTOTHENATE
SYNTHETASE

(Campylobacter
jejuni) 		PF02569
(Pantoate_ligase) 		4 LEU A 138
ILE A  91
PRO A  92
PHE A  55
 None
 1.23A 3s3vA-3uy4A:
undetectable		 3s3vA-3uy4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		4 LEU A 483
ILE A 492
PRO A 493
PHE A 496
 None
 0.95A 3s3vA-3vilA:
undetectable		 3s3vA-3vilA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		4 LEU A 398
ILE A 505
PRO A 504
PHE A 231
 None
 1.21A 3s3vA-3w3sA:
undetectable		 3s3vA-3w3sA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 ASP A 570
LEU A 574
ILE A 231
PHE A 232
 None
 1.02A 3s3vA-4aeeA:
undetectable		 3s3vA-4aeeA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 LEU B2985
ILE B3104
PRO B2995
PHE B3009
 None
 1.07A 3s3vA-4bedB:
undetectable		 3s3vA-4bedB:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SAR1P

(Saccharomyces
cerevisiae) 		PF00025
(Arf) 		4 ASP B  73
LEU B  74
ILE B  94
PHE B  96
 MG  B1191 ( 4.2A)
None
None
None
 1.16A 3s3vA-4bziB:
undetectable		 3s3vA-4bziB:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dag FUSION GLYCOPROTEIN
F0

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		4 LEU A 227
ILE A 275
PRO A 274
PHE A 276
 None
 1.23A 3s3vA-4dagA:
undetectable		 3s3vA-4dagA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 LEU A 882
ILE A 841
PRO A 842
PHE A 844
 None
 1.19A 3s3vA-4gfhA:
undetectable		 3s3vA-4gfhA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		4 ASP B  70
LEU B 174
ILE B  74
PHE B  43
 None
None
CL  B 304 (-4.3A)
GOL  B 303 (-2.9A)
 1.23A 3s3vA-4gmjB:
undetectable		 3s3vA-4gmjB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0n DNMT2

(Spodoptera
frugiperda) 		PF00145
(DNA_methylase) 		4 ASP A 106
LEU A 105
ILE A  64
PRO A  61
 CA  A 402 (-2.5A)
None
None
None
 1.15A 3s3vA-4h0nA:
undetectable		 3s3vA-4h0nA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		4 ASP A  67
LEU A 320
ILE A  74
PRO A  76
 None
 1.23A 3s3vA-4h59A:
undetectable		 3s3vA-4h59A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h65 PYRIMIDINE PRECURSOR
BIOSYNTHESIS ENZYME
THI5

(Saccharomyces
cerevisiae) 		PF09084
(NMT1) 		4 ASP A 229
LEU A 232
ILE A  19
PRO A  20
 None
 1.22A 3s3vA-4h65A:
undetectable		 3s3vA-4h65A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqf METHIONYL-TRNA
FORMYLTRANSFERASE

(Bacillus
anthracis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 ASP A  23
LEU A  20
ILE A 185
PRO A 182
 None
 1.17A 3s3vA-4iqfA:
undetectable		 3s3vA-4iqfA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jja HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF07075
(DUF1343) 		4 ASP A 126
LEU A 158
ILE A  43
PHE A  67
 None
 1.17A 3s3vA-4jjaA:
undetectable		 3s3vA-4jjaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq9 DIHYDROLIPOYL
DEHYDROGENASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ASP A 208
LEU A 234
ILE A 211
PRO A 212
 None
 1.17A 3s3vA-4jq9A:
undetectable		 3s3vA-4jq9A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 738
ILE A 742
PRO A 743
PHE A 748
 None
 1.16A 3s3vA-4m7eA:
undetectable		 3s3vA-4m7eA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mea PREDICTED PROTEIN

(Acinetobacter
nosocomialis) 		PF00561
(Abhydrolase_1) 		4 ASP A 158
LEU A 159
ILE A 185
PRO A 184
 None
 1.19A 3s3vA-4meaA:
undetectable		 3s3vA-4meaA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 ASP E 572
LEU E 573
ILE E 646
PRO E 645
 None
 1.21A 3s3vA-4mh0E:
undetectable		 3s3vA-4mh0E:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzl MYOSIN A TAIL DOMAIN
INTERACTING PROTEIN

(Plasmodium
falciparum) 		no annotation 4 ASP A 139
LEU A 203
ILE A 145
PHE A 148
 None
 1.16A 3s3vA-4mzlA:
undetectable		 3s3vA-4mzlA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN

(Sphingobium
chlorophenolicum) 		PF03466
(LysR_substrate) 		4 LEU A 270
ILE A 247
PRO A 248
PHE A 231
 None
 1.11A 3s3vA-4rnsA:
undetectable		 3s3vA-4rnsA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ro5 SAT DOMAIN FROM CAZM

(Chaetomium
globosum) 		PF16073
(SAT) 		4 ASP A 388
LEU A 122
ILE A 391
PRO A 392
 None
 1.09A 3s3vA-4ro5A:
undetectable		 3s3vA-4ro5A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 LEU A1814
ILE A1793
PRO A1828
PHE A1789
 None
 1.12A 3s3vA-4uclA:
undetectable		 3s3vA-4uclA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 311
LEU A 310
ILE A 275
PRO A 272
 None
 1.12A 3s3vA-4wumA:
undetectable		 3s3vA-4wumA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjy CHALCONE SYNTHASE 1

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 314
LEU A 313
ILE A 278
PRO A 275
 None
 1.13A 3s3vA-4yjyA:
undetectable		 3s3vA-4yjyA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 607
ILE A 611
PRO A 612
PHE A 617
 None
 1.07A 3s3vA-4z64A:
undetectable		 3s3vA-4z64A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azs OUTER MEMBRANE
PROTEIN OPRJ

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		4 ASP A 164
LEU A 167
ILE A 242
PRO A 243
 None
 1.23A 3s3vA-5azsA:
undetectable		 3s3vA-5azsA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		4 ASP A 420
ILE A 133
PRO A 134
PHE A 137
 None
 0.96A 3s3vA-5dboA:
undetectable		 3s3vA-5dboA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		4 ASP A 277
ILE A  74
PRO A  75
PHE A  76
 None
 0.89A 3s3vA-5hyhA:
undetectable		 3s3vA-5hyhA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5itq ENDONUCLEASE 8-LIKE
1

(Homo sapiens) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH)
PF09292
(Neil1-DNA_bind) 		4 LEU A 166
ILE A 161
PRO A 160
PHE A 191
 None
 1.17A 3s3vA-5itqA:
undetectable		 3s3vA-5itqA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j47 LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF06431
(Polyoma_lg_T_C) 		4 ASP A 628
LEU A 627
ILE A 608
PHE A 613
 None
 1.23A 3s3vA-5j47A:
undetectable		 3s3vA-5j47A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
BIOSYNTHESIS PROTEIN
YBDZ
ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF03621
(MbtH)
PF13193
(AMP-binding_C) 		4 ASP A 788
LEU A 787
PRO B   6
PHE B   7
 None
 1.06A 3s3vA-5ja1A:
undetectable		 3s3vA-5ja1A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkq PFVFT1

(Plasmodium
falciparum) 		no annotation 4 LEU A 257
ILE A 274
PRO A 275
PHE A 276
 None
 1.08A 3s3vA-5jkqA:
undetectable		 3s3vA-5jkqA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 441
ILE A 161
PRO A 160
PHE A 419
 None
 1.05A 3s3vA-5macA:
undetectable		 3s3vA-5macA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 4 ASP A  61
LEU A  74
PRO A  57
PHE A  93
 None
 1.12A 3s3vA-5o8rA:
undetectable		 3s3vA-5o8rA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		4 ASP B 257
LEU B 256
ILE B 432
PRO B 431
 None
 0.98A 3s3vA-5of4B:
undetectable		 3s3vA-5of4B:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pal PARVALBUMIN

(Triakis
semifasciata) 		PF13499
(EF-hand_7) 		4 ASP A  76
LEU A  77
ILE A  15
PHE A  70
 None
 1.23A 3s3vA-5palA:
undetectable		 3s3vA-5palA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 4 ASP A 311
LEU A 310
ILE A 275
PRO A 272
 None
 1.11A 3s3vA-5uc5A:
undetectable		 3s3vA-5uc5A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujd SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNI

(Staphylococcus
pseudintermedius) 		no annotation 4 ASP A 170
LEU A 169
ILE A  93
PRO A  94
 None
 1.16A 3s3vA-5ujdA:
undetectable		 3s3vA-5ujdA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE

(Neurospora
crassa) 		no annotation 4 LEU C  36
ILE C  51
PRO C  52
PHE C 250
 None
 1.15A 3s3vA-5v12C:
undetectable		 3s3vA-5v12C:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx4 ALKYLQUINOLONE
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 317
LEU A 316
ILE A 281
PRO A 278
 None
 1.06A 3s3vA-5wx4A:
undetectable		 3s3vA-5wx4A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypt STILBENECARBOXYLATE
SYNTHASE 1

(Marchantia
polymorpha) 		no annotation 4 ASP A 313
LEU A 312
ILE A 277
PRO A 274
 None
 1.10A 3s3vA-5yptA:
undetectable		 3s3vA-5yptA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 4 ASP A1810
ILE A1769
PRO A1805
PHE A1772
 None
 1.09A 3s3vA-5zalA:
undetectable		 3s3vA-5zalA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ay4 CYP51, STEROL
14ALPHA-DEMETHYLASE

(Naegleria
fowleri) 		no annotation 4 ASP A 280
LEU A 241
ILE A 286
PHE A 134
 None
 1.22A 3s3vA-6ay4A:
undetectable		 3s3vA-6ay4A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cqb CHALCONE SYNTHASE

(Piper
methysticum) 		no annotation 4 ASP A 312
LEU A 311
ILE A 276
PRO A 273
 None
 1.13A 3s3vA-6cqbA:
undetectable		 3s3vA-6cqbA:
16.76