SIMILAR PATTERNS OF AMINO ACIDS FOR 3RXH_A_HSMA7_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 BEN  A 246 (-3.0A)
BEN  A 246 (-3.0A)
SO4  A 248 ( 2.5A)
None
BEN  A 246 (-3.3A)
 0.31A 3rxhA-1a0jA:
41.5		 3rxhA-1a0jA:
73.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1afq BOVINE
GAMMA-CHYMOTRYPSIN

(Bos taurus) 		PF00089
(Trypsin) 		4 SER C 190
SER C 195
VAL C 213
GLY C 226
 None
0FG  C 301 ( 3.0A)
None
0FG  C 301 ( 4.4A)
 0.67A 3rxhA-1afqC:
11.5		 3rxhA-1afqC:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bqy PLASMINOGEN
ACTIVATOR

(Trimeresurus
stejnegeri) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
VAL A 213
GLY A 226
 0GJ  A   1 (-3.1A)
0GJ  A   1 ( 1.4A)
None
0GJ  A   1 ( 4.3A)
 0.41A 3rxhA-1bqyA:
35.4		 3rxhA-1bqyA:
42.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dlk THROMBIN HEAVY CHAIN

(Bos taurus) 		PF00089
(Trypsin) 		4 SER B 190
SER B 195
VAL B 213
GLY B 226
 None
 0.70A 3rxhA-1dlkB:
14.2		 3rxhA-1dlkB:
43.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		4 ASP B 189
SER B 190
SER B 195
GLY B 226
 None
 0.32A 3rxhA-1ekbB:
36.7		 3rxhA-1ekbB:
36.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1elv COMPLEMENT C1S
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 ASP A 611
SER A 612
SER A 617
VAL A 638
GLY A 648
 None
None
SO4  A2001 ( 2.7A)
None
None
 0.31A 3rxhA-1elvA:
11.0		 3rxhA-1elvA:
30.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ept PORCINE E-TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 ASP C 189
SER C 190
SER C 195
VAL C 213
GLY C 226
 None
 0.25A 3rxhA-1eptC:
16.3		 3rxhA-1eptC:
81.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 ASP A 339
SER A 340
VAL A 192
GLY A 189
 None
 1.07A 3rxhA-1fuiA:
undetectable		 3rxhA-1fuiA:
18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.3A)
 0.33A 3rxhA-1fxyA:
38.0		 3rxhA-1fxyA:
55.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		4 ASP A 145
SER A 200
VAL A 334
GLY A 141
 None
 1.04A 3rxhA-1gk2A:
undetectable		 3rxhA-1gk2A:
17.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4w TRYPSIN IVA

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 BEN  A 250 (-2.9A)
BEN  A 250 (-2.9A)
BEN  A 250 (-3.6A)
None
BEN  A 250 (-3.3A)
 0.24A 3rxhA-1h4wA:
43.3		 3rxhA-1h4wA:
72.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h9h TRYPSIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 ASP E 189
SER E 190
SER E 195
VAL E 213
GLY E 226
 None
 0.34A 3rxhA-1h9hE:
43.6		 3rxhA-1h9hE:
82.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 ASP A 172
SER A  69
VAL A  68
GLY A  65
 None
 1.01A 3rxhA-1i7qA:
undetectable		 3rxhA-1i7qA:
16.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1id5 THROMBIN

(Bos taurus) 		PF00089
(Trypsin) 		4 ASP H 189
SER H 195
VAL H 213
GLY H 226
 None
 0.56A 3rxhA-1id5H:
34.1		 3rxhA-1id5H:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j17 TRYPSIN II, ANIONIC

(Rattus
norvegicus) 		PF00089
(Trypsin) 		4 ASP T 189
SER T 195
VAL T 213
GLY T 226
 ZEN  T   1 ( 3.8A)
SO4  T 600 ( 2.6A)
ZEN  T   1 (-4.1A)
ZEN  T   1 (-3.7A)
 0.24A 3rxhA-1j17T:
43.1		 3rxhA-1j17T:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		4 ASP H 189
SER H 195
VAL H 213
GLY H 226
 None
 0.33A 3rxhA-1kigH:
34.4		 3rxhA-1kigH:
40.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mbq TRYPSIN

(Oncorhynchus
keta) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 BEN  A1222 (-2.9A)
BEN  A1222 (-2.9A)
BEN  A1222 (-3.5A)
None
BEN  A1222 (-3.4A)
 0.30A 3rxhA-1mbqA:
41.2		 3rxhA-1mbqA:
65.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP H 189
SER H 195
VAL H 213
GLY H 226
 CR9  H 256 (-2.4A)
CR9  H 256 (-1.5A)
CR9  H 256 (-4.3A)
CR9  H 256 (-3.0A)
 0.22A 3rxhA-1o5fH:
19.2		 3rxhA-1o5fH:
41.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1op2 VENOM SERINE
PROTEINASE

(Deinagkistrodon
acutus) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
VAL A 213
GLY A 226
 None
 0.39A 3rxhA-1op2A:
34.4		 3rxhA-1op2A:
41.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 190
SER A 195
GLY A 226
 0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.5A)
 0.31A 3rxhA-1orfA:
12.8		 3rxhA-1orfA:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfx FACTOR IXA

(Sus scrofa) 		PF00089
(Trypsin) 		4 ASP C 189
SER C 190
SER C 195
GLY C 226
 0G6  C 301 (-3.0A)
0G6  C 301 (-2.6A)
0G6  C 301 (-1.4A)
0G6  C 301 ( 3.5A)
 0.36A 3rxhA-1pfxC:
34.8		 3rxhA-1pfxC:
43.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pq5 TRYPSIN

(Fusarium
oxysporum) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 210
GLY A 223
 ARG  A 703 (-2.0A)
ARG  A 703 (-2.5A)
ARG  A 703 (-2.3A)
ARG  A 703 (-4.5A)
ARG  A 703 (-2.6A)
 0.37A 3rxhA-1pq5A:
34.2		 3rxhA-1pq5A:
44.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 667
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.0A)
 0.35A 3rxhA-1q3xA:
34.1		 3rxhA-1q3xA:
29.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 ASP B 114
SER B 113
VAL B  94
GLY B  89
 None
 1.06A 3rxhA-1qh1B:
undetectable		 3rxhA-1qh1B:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
ALPHA-SUBUNIT

(Pseudomonas
putida) 		PF00676
(E1_dh)
PF12573
(OxoDH_E1alpha_N) 		4 ASP A 159
SER A 155
SER A 104
GLY A 163
 None
 1.11A 3rxhA-1qs0A:
undetectable		 3rxhA-1qs0A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ASP A 408
SER A 377
VAL A 378
GLY A 346
 None
 1.03A 3rxhA-1r8wA:
undetectable		 3rxhA-1r8wA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgi GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		4 ASP G 308
SER G 351
VAL G 350
GLY G 310
 None
 1.07A 3rxhA-1rgiG:
undetectable		 3rxhA-1rgiG:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xo8 AT1G01470

(Arabidopsis
thaliana) 		PF03168
(LEA_2) 		4 ASP A  78
SER A  46
VAL A  47
GLY A  80
 None
 1.08A 3rxhA-1xo8A:
undetectable		 3rxhA-1xo8A:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.30A 3rxhA-1ym0A:
36.3		 3rxhA-1ym0A:
39.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 ASP B 116
SER B 115
VAL B  96
GLY B  91
 None
 1.04A 3rxhA-2afhB:
undetectable		 3rxhA-2afhB:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckn BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Mus musculus) 		PF00047
(ig) 		4 ASP A  79
SER A  80
VAL A  34
GLY A  37
 None
 1.03A 3rxhA-2cknA:
undetectable		 3rxhA-2cknA:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-3.4A)
None
BEN  A 301 (-3.2A)
 0.28A 3rxhA-2eekA:
40.8		 3rxhA-2eekA:
62.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
VAL A 213
GLY A 226
 DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
 0.41A 3rxhA-2ei8A:
35.7		 3rxhA-2ei8A:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f91 HEPATOPANCREAS
TRYPSIN

(Astacus
leptodactylus) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 227
 None
 0.34A 3rxhA-2f91A:
36.8		 3rxhA-2f91A:
44.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2p TRANSTHYRETIN-LIKE
PROTEIN

(Escherichia
coli) 		PF00576
(Transthyretin) 		4 ASP A  43
SER A   7
VAL A   8
GLY A  46
 None
ZN  A1005 ( 4.1A)
None
None
 1.10A 3rxhA-2g2pA:
undetectable		 3rxhA-2g2pA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpz TRANSTHYRETIN-LIKE
PROTEIN

(Salmonella
enterica) 		PF00576
(Transthyretin) 		4 ASP A  44
SER A   8
VAL A   9
GLY A  47
 SO4  A 116 (-3.1A)
None
None
None
 1.06A 3rxhA-2gpzA:
undetectable		 3rxhA-2gpzA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A 244
SER A 276
VAL A 275
GLY A 247
 None
 0.95A 3rxhA-2h6eA:
undetectable		 3rxhA-2h6eA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jet CHYMOTRYPSINOGEN B
CHAIN C

(Rattus
norvegicus) 		PF00089
(Trypsin) 		4 SER C 217
SER C 195
VAL C 213
GLY C 226
 None
 1.07A 3rxhA-2jetC:
9.6		 3rxhA-2jetC:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
VAL A 213
GLY A 226
 BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 (-3.4A)
 0.29A 3rxhA-2oq5A:
14.5		 3rxhA-2oq5A:
37.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oua SERINE PROTEASE

(Nocardiopsis
alba) 		PF00089
(Trypsin) 		4 SER A 198
SER A 120
VAL A 120
GLY A  44
 None
 0.97A 3rxhA-2ouaA:
9.4		 3rxhA-2ouaA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pks THROMBIN HEAVY CHAIN
FRAGMENT

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP C 229
SER C 235
VAL C 255
GLY C 268
 G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.0A)
 0.33A 3rxhA-2pksC:
12.2		 3rxhA-2pksC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE

(Renilla
reniformis) 		PF00561
(Abhydrolase_1) 		4 ASP A  31
SER A  32
SER A  84
GLY A  88
 None
 0.90A 3rxhA-2psfA:
undetectable		 3rxhA-2psfA:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psy KALLIKREIN-5

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.31A 3rxhA-2psyA:
38.7		 3rxhA-2psyA:
47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP B 631
SER B 637
VAL B 657
GLY B 668
 None
 0.57A 3rxhA-2qy0B:
32.0		 3rxhA-2qy0B:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2w PLASMINOGEN
ACTIVATOR, UROKINASE

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP U 189
SER U 190
SER U 195
VAL U 213
GLY U 226
 4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.2A)
 0.59A 3rxhA-2r2wU:
15.4		 3rxhA-2r2wU:
39.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r79 PERIPLASMIC BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF01497
(Peripla_BP_2) 		4 SER A  57
SER A  68
VAL A  53
GLY A  34
 None
 0.92A 3rxhA-2r79A:
undetectable		 3rxhA-2r79A:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wpm COAGULATION FACTOR
IXA HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP S 189
SER S 190
SER S 195
GLY S 226
 None
 0.35A 3rxhA-2wpmS:
36.1		 3rxhA-2wpmS:
41.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		4 ASP A  49
SER A  46
SER A 103
VAL A 123
 None
None
EB4  A1300 ( 4.4A)
None
 1.06A 3rxhA-2xuzA:
undetectable		 3rxhA-2xuzA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 ASP A 520
SER A 521
SER A 412
VAL A 525
 None
 1.06A 3rxhA-2xycA:
undetectable		 3rxhA-2xycA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 ASP A 195
SER A 141
VAL A 140
GLY A 138
 None
 1.11A 3rxhA-2z2zA:
undetectable		 3rxhA-2z2zA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zec TRYPTASE BETA 2

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 203
SER A 204
SER A 209
VAL A 227
GLY A 240
 11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.6A)
 0.35A 3rxhA-2zecA:
32.8		 3rxhA-2zecA:
40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3beu TRYPSIN

(Streptomyces
griseus) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
VAL A 213
GLY A 226
 BEN  A 247 (-3.0A)
SO4  A 246 ( 2.5A)
None
BEN  A 247 (-3.5A)
 0.34A 3rxhA-3beuA:
32.2		 3rxhA-3beuA:
36.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP H 189
SER H 195
VAL H 213
GLY H 226
 0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 ( 3.9A)
 0.45A 3rxhA-3f6uH:
35.1		 3rxhA-3f6uH:
36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gov MASP-1

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP B 640
SER B 646
VAL B 666
GLY B 679
 None
 0.35A 3rxhA-3govB:
35.5		 3rxhA-3govB:
35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gym PROSTASIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
VAL A 213
GLY A 226
 None
 0.29A 3rxhA-3gymA:
35.1		 3rxhA-3gymA:
40.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2y GTPASE FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01926
(MMR_HSR1) 		4 ASP A  81
SER A 337
SER A 362
GLY A  84
 None
 1.03A 3rxhA-3h2yA:
undetectable		 3rxhA-3h2yA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7v PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1377C

(Streptococcus
mutans) 		PF01300
(Sua5_yciO_yrdC) 		4 ASP A  40
SER A  39
VAL A  19
GLY A  23
 None
 1.06A 3rxhA-3l7vA:
undetectable		 3rxhA-3l7vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n8u IMELYSIN PEPTIDASE

(Bacteroides
ovatus) 		PF09375
(Peptidase_M75) 		4 ASP A 164
SER A 162
SER A 171
GLY A 165
 None
 1.11A 3rxhA-3n8uA:
undetectable		 3rxhA-3n8uA:
22.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r3g THROMBIN HEAVY CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP B 189
SER B 195
VAL B 213
GLY B 226
 None
 0.53A 3rxhA-3r3gB:
34.0		 3rxhA-3r3gB:
37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
VAL A 209
GLY A 223
 None
 0.36A 3rxhA-3s69A:
34.9		 3rxhA-3s69A:
44.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8k LATEX SERINE
PROTEINASE INHIBITOR

(Carica papaya) 		PF00197
(Kunitz_legume) 		4 ASP A  55
SER A  24
VAL A  23
GLY A  57
 CO  A 186 (-2.3A)
None
None
None
 0.90A 3rxhA-3s8kA:
undetectable		 3rxhA-3s8kA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sul CERATO-PLATANIN-LIKE
PROTEIN

(Moniliophthora
perniciosa) 		PF07249
(Cerato-platanin) 		4 ASP A  26
SER A  57
VAL A  59
GLY A 103
 None
 1.09A 3rxhA-3sulA:
undetectable		 3rxhA-3sulA:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes) 		PF00089
(Trypsin) 		4 ASP A 973
SER A 974
SER A 979
GLY A1010
 None
 0.29A 3rxhA-3w94A:
37.2		 3rxhA-3w94A:
35.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A 439
SER A 482
VAL A 483
GLY A 123
 None
 1.03A 3rxhA-3zz1A:
undetectable		 3rxhA-3zz1A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A 439
SER A 482
VAL A 483
GLY A 124
 None
 1.08A 3rxhA-3zz1A:
undetectable		 3rxhA-3zz1A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 SER A  31
SER A 382
VAL A 381
GLY A  54
 None
 1.03A 3rxhA-4adeA:
undetectable		 3rxhA-4adeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxw FACTOR XA

(Pseudonaja
textilis) 		PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		4 ASP A 356
SER A 362
VAL A 380
GLY A 393
 0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.3A)
 0.39A 3rxhA-4bxwA:
33.0		 3rxhA-4bxwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 ASP A 337
SER A 338
VAL A 190
GLY A 187
 None
 1.08A 3rxhA-4c22A:
undetectable		 3rxhA-4c22A:
15.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.71A 3rxhA-4d9rA:
16.5		 3rxhA-4d9rA:
37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP A 181
SER A 182
SER A 187
GLY A 218
 None
 0.55A 3rxhA-4dgjA:
37.2		 3rxhA-4dgjA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP H 627
SER H 628
VAL H 653
GLY H 667
 None
 0.40A 3rxhA-4fxgH:
33.4		 3rxhA-4fxgH:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gso THROMBIN-LIKE ENZYME
BJUSSUSP-1

(Bothrops
jararacussu) 		PF00089
(Trypsin) 		4 ASP A 172
SER A 178
VAL A 192
GLY A 206
 None
 0.30A 3rxhA-4gsoA:
undetectable		 3rxhA-4gsoA:
44.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3

(Homo sapiens) 		PF00089
(Trypsin) 		4 ASP E 639
SER E 645
VAL E 665
GLY E 680
 None
 0.44A 3rxhA-4iw4E:
33.9		 3rxhA-4iw4E:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE

(Francisella
philomiragia) 		PF01048
(PNP_UDP_1) 		4 ASP A 196
SER A 195
VAL A  77
GLY A  79
 ADE  A 301 (-2.8A)
ADE  A 301 (-3.3A)
None
ADE  A 301 (-3.7A)
 1.02A 3rxhA-4josA:
undetectable		 3rxhA-4josA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE

(Sulfurimonas
denitrificans) 		PF01048
(PNP_UDP_1) 		4 ASP A 196
SER A 195
VAL A  76
GLY A  78
 ADE  A 305 (-2.8A)
ADE  A 305 (-3.2A)
ADE  A 305 (-4.8A)
ADE  A 305 (-3.6A)
 1.02A 3rxhA-4jwtA:
undetectable		 3rxhA-4jwtA:
22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k8y KALLIKREIN-4

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.50A 3rxhA-4k8yA:
37.1		 3rxhA-4k8yA:
40.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0m PUTATIVE
5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Borreliella
burgdorferi) 		PF01048
(PNP_UDP_1) 		4 ASP A 204
SER A 203
SER A 223
GLY A  81
 ADE  A 301 (-3.0A)
ADE  A 301 (-3.1A)
None
ADE  A 301 (-3.6A)
 1.03A 3rxhA-4l0mA:
undetectable		 3rxhA-4l0mA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 3KM  A 900 (-2.9A)
3KM  A 900 (-2.9A)
3KM  A 900 (-3.6A)
None
3KM  A 900 (-3.2A)
 0.23A 3rxhA-4r0iA:
37.7		 3rxhA-4r0iA:
40.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 ASP A 435
SER A 526
SER A 524
GLY A 518
 None
 1.08A 3rxhA-4r4zA:
undetectable		 3rxhA-4r4zA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wwy TRYPSIN-1

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.29A 3rxhA-4wwyA:
42.3		 3rxhA-4wwyA:
74.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ylq COAGULATION FACTOR
VII

(Homo sapiens) 		PF00089
(Trypsin) 		5 ASP H 189
SER H 190
SER H 195
VAL H 213
GLY H 226
 0Z7  H 501 (-2.3A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
0Z7  H 501 (-3.0A)
 0.33A 3rxhA-4ylqH:
35.6		 3rxhA-4ylqH:
40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z19 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Yersinia pestis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 139
SER A  83
VAL A  51
GLY A  55
 None
 1.06A 3rxhA-4z19A:
undetectable		 3rxhA-4z19A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9k VHH2(F5) ANTIBODY

(Vicugna pacos) 		PF07686
(V-set) 		4 ASP B  30
SER B  69
VAL B  75
GLY B  73
 None
 1.01A 3rxhA-4z9kB:
undetectable		 3rxhA-4z9kB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpr HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA

(Mus musculus) 		PF00989
(PAS)
PF08447
(PAS_3) 		4 ASP B 106
SER B  65
VAL B 110
GLY B 107
 None
 1.11A 3rxhA-4zprB:
undetectable		 3rxhA-4zprB:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		4 ASP A 564
SER A 507
VAL A 508
GLY A 567
 None
 1.07A 3rxhA-5a42A:
undetectable		 3rxhA-5a42A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3n ANTI-H4K20ME1_SCFV

(Mus musculus) 		PF07686
(V-set) 		4 ASP A 168
SER A 173
SER A 194
GLY A 210
 None
 0.83A 3rxhA-5b3nA:
undetectable		 3rxhA-5b3nA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chn ANTIBODY 5M16 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ASP H  85
SER H  88
VAL H 120
GLY H  15
 None
 1.07A 3rxhA-5chnH:
undetectable		 3rxhA-5chnH:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 ASP A 126
SER A 125
SER A  72
VAL A  89
 None
 1.00A 3rxhA-5cjfA:
undetectable		 3rxhA-5cjfA:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fcr COMPLEMENT FACTOR D

(Mus musculus) 		PF00089
(Trypsin) 		4 ASP A 189
SER A 195
VAL A 213
GLY A 226
 None
 0.71A 3rxhA-5fcrA:
12.9		 3rxhA-5fcrA:
36.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 SER A 508
SER A 506
VAL A 552
GLY A 155
 None
 1.11A 3rxhA-5fjjA:
undetectable		 3rxhA-5fjjA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE

(Helicobacter
pylori) 		PF01048
(PNP_UDP_1) 		4 ASP A 198
SER A 197
VAL A  78
GLY A  80
 4CT  A 301 (-2.2A)
4CT  A 301 ( 2.8A)
4CT  A 301 (-4.1A)
4CT  A 301 (-3.4A)
 0.95A 3rxhA-5k1zA:
undetectable		 3rxhA-5k1zA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ASP A 239
SER A 238
VAL A 246
GLY A 242
 None
 0.89A 3rxhA-5kgnA:
undetectable		 3rxhA-5kgnA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECF

(Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 ASP F 213
SER F 214
VAL F 173
GLY F 284
 None
 0.65A 3rxhA-5mg3F:
undetectable		 3rxhA-5mg3F:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 4 SER A 147
SER A  80
VAL A  79
GLY A  20
 None
 1.04A 3rxhA-5mrrA:
9.1		 3rxhA-5mrrA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		4 ASP B 214
SER B 220
VAL B 240
GLY B 253
 0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.6A)
 0.32A 3rxhA-5to3B:
34.6		 3rxhA-5to3B:
27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ubm COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		no annotation 5 ASP A 626
SER A 627
SER A 632
VAL A 653
GLY A 663
 None
 0.51A 3rxhA-5ubmA:
11.7		 3rxhA-5ubmA:
34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Chaetomium
thermophilum) 		no annotation 4 ASP A 145
SER A  95
VAL A  94
GLY A 118
 None
 1.07A 3rxhA-5w8mA:
undetectable		 3rxhA-5w8mA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx4 ALKYLQUINOLONE
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 SER A 378
SER A 347
VAL A 348
GLY A 174
 None
 1.03A 3rxhA-5wx4A:
undetectable		 3rxhA-5wx4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xrf SNAKE VENOM SERINE
PROTEASE DA-36

(Deinagkistrodon
acutus) 		no annotation 4 ASP A 200
SER A 206
VAL A 220
GLY A 234
 None
 0.60A 3rxhA-5xrfA:
13.4		 3rxhA-5xrfA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3

(Homo sapiens) 		no annotation 4 ASP A 550
SER A 592
VAL A 607
GLY A 605
 None
 0.92A 3rxhA-6cvzA:
undetectable		 3rxhA-6cvzA:
18.10