SIMILAR PATTERNS OF AMINO ACIDS FOR 3RX3_A_SUZA317

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		5 TRP A  20
TYR A  48
HIS A 110
PHE A 122
CYH A 298
 NAP  A 350 (-4.4A)
NAP  A 350 (-4.8A)
NAP  A 350 (-4.0A)
None
NAP  A 350 ( 4.1A)
 0.78A 3rx3A-1c9wA:
50.3		 3rx3A-1c9wA:
69.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bgs ALDOSE REDUCTASE

(Hordeum vulgare) 		PF00248
(Aldo_ket_red) 		5 TRP A  32
TYR A  60
HIS A 121
TRP A 122
LEU A 300
 BCT  A1322 ( 3.3A)
BCT  A1322 ( 4.4A)
BCT  A1322 ( 3.9A)
BCT  A1322 (-4.3A)
None
 1.04A 3rx3A-2bgsA:
42.4		 3rx3A-2bgsA:
39.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		10 TRP A  20
VAL A  47
TYR A  48
HIS A 110
TRP A 111
PHE A 122
TRP A 219
CYH A 298
LEU A 300
SER A 302
 2CL  A 317 ( 3.4A)
2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 ( 4.0A)
2CL  A 317 ( 4.9A)
None
2CL  A 317 (-3.5A)
None
None
 0.50A 3rx3A-2is7A:
54.2		 3rx3A-2is7A:
99.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h7u ALDO-KETO REDUCTASE

(Arabidopsis
thaliana) 		PF00248
(Aldo_ket_red) 		5 TRP A  24
TYR A  52
HIS A 114
PHE A 295
SER A 294
 ACT  A 501 ( 3.2A)
ACT  A 501 ( 4.4A)
ACT  A 501 ( 3.8A)
None
None
 1.04A 3rx3A-3h7uA:
44.4		 3rx3A-3h7uA:
47.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		6 TRP A  12
VAL A  39
TYR A  40
HIS A 104
PHE A 118
CYH A 301
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
None
NAP  A 400 ( 4.0A)
 1.11A 3rx3A-3krbA:
41.3		 3rx3A-3krbA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		6 TRP A  12
VAL A  39
TYR A  40
HIS A 104
TRP A 105
CYH A 301
 UNX  A 402 (-4.3A)
None
UNX  A 402 (-4.4A)
UNX  A 402 (-4.1A)
NAP  A 400 ( 4.3A)
NAP  A 400 ( 4.0A)
 0.50A 3rx3A-3krbA:
41.3		 3rx3A-3krbA:
40.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o3r ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B7

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 TRP A  21
VAL A  48
TYR A  49
HIS A 111
LEU A 301
 None
None
NAP  A 317 (-4.9A)
NAP  A 317 (-4.3A)
None
 0.60A 3rx3A-3o3rA:
50.3		 3rx3A-3o3rA:
65.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hbk ALDO-KETO REDUCTASE
FAMILY 1, MEMBER B4
(ALDOSE REDUCTASE)

(Schistosoma
japonicum) 		PF00248
(Aldo_ket_red) 		6 VAL A  47
TYR A  48
HIS A 110
TRP A 111
PHE A 122
LEU A 295
 None
 0.86A 3rx3A-4hbkA:
45.8		 3rx3A-4hbkA:
51.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jgy ALDOSE REDUCTASE,
AKR4C13

(Zea mays) 		PF00248
(Aldo_ket_red) 		5 TRP A  31
TYR A  59
HIS A 120
TRP A 121
LEU A 299
 EDO  A 402 ( 3.2A)
6KB  A 401 ( 4.6A)
6KB  A 401 ( 4.0A)
6KB  A 401 ( 4.4A)
EDO  A 404 (-4.3A)
 1.00A 3rx3A-5jgyA:
41.7		 3rx3A-5jgyA:
39.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 TRP X  21
VAL X  48
TYR X  49
HIS X 111
PHE X 123
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
DQP  X 402 (-3.7A)
 1.09A 3rx3A-5liyX:
50.4		 3rx3A-5liyX:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		6 TRP X  21
VAL X  48
TYR X  49
HIS X 111
TRP X 220
CYH X 299
 DQP  X 402 ( 3.5A)
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
None
DQP  X 402 (-4.0A)
 0.70A 3rx3A-5liyX:
50.4		 3rx3A-5liyX:
66.67